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https://www.readbyqxmd.com/read/29222891/effects-of-preoperative-oral-carbohydrate-therapy-on-perioperative-glucose-metabolism-during-oral-maxillofacial-surgery-randomised-clinical-trial
#1
Kanako Esaki, Masanori Tsukamoto, Eiji Sakamoto, Takeshi Yokoyama
BACKGROUND AND OBJECTIVES: Preoperative oral carbohydrate therapy has been suggested to attenuate postoperative insulin resistance. The purpose of this study was to investigate the effect of a carbohydrate-rich beverage given preoperatively on intraoperative glucose metabolism. METHODS AND STUDY DESIGN: This study was a randomised, open-label, placebo-controlled trial. Patients undergoing oral-maxillofacial surgery were divided into two groups. In the glucose group, patients took glucose (50 g/278 mL, p...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29221844/gabapentin-as-an-adjuvant-therapy-for-prevention-of-acute-phantom-limb-pain-in-pediatric-patients-undergoing-amputation-for-malignant-bone-tumors-a-prospective-double-blind-randomized-controlled-trial
#2
Xiandi Wang, Ying Yi, Dingbo Tang, Yi Chen, Yanhua Jiang, Jun Peng, Jiwei Xiao
CONTEXT: Gabapentin is reported to have an analgesic effect of reducing phantom-limb pain(PLP) in adult patients. There's no study on preoperative use of gabapentin in pediatric population in term of PLP prevention. OBJECTIVE: To determine whether gabapentin could be used as an adjuvant agent of opioid-based pain control to lower the rate of phantom-limb pain in pediatric patients undergoing amputation for malignant bone tumors in observation period of 60 days post-operatively...
December 5, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29221299/surgical-site-infections-after-lung-resection-a-prospective-study-of-risk-factors-in-1-091-consecutive-patients
#3
Andrea Imperatori, Elisa Nardecchia, Lorenzo Dominioni, Daniele Sambucci, Sebastiano Spampatti, Giancarlo Feliciotti, Nicola Rotolo
Background: To assess incidence and risk factors of surgical site infections (SSI) (wound infection, pneumonia, empyema) in a monocentric series of patients undergoing lung resection over a decade. Methods: All patients undergoing lung resection at our institution in 2006-2015 [wedge resection, n=579; lobectomy, n=472 (12% after chemo/radiotherapy); pneumonectomy, n=40 (47% after chemo/radiotherapy)], were prospectively enrolled. Perioperative SSI risk factors were recorded: age, gender, blood haemoglobin, lymphocyte count, serum albumin, forced expiratory volume in 1 second percentage (FEV1%) of predicted, antibiotic prophylaxis, length of stay, diabetes, malignancy, steroid therapy, induction chemo/radiotherapy, resection in 2006-2010/2011-2015, urgent/elective procedure, videothoracoscopic/open approach, resection type, operative time...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29219922/multimodal-prehabilitation-programs-as-a-bundle-of-care-in-gastrointestinal-cancer-surgery-a-systematic-review
#4
Vladimir Bolshinsky, Michael H-G Li, Hilmy Ismail, Kate Burbury, Bernhard Riedel, Alexander Heriot
BACKGROUND: Prehabilitation reflects a proactive process of preoperative optimization undertaken between cancer diagnosis and definitive surgical treatment, with the intent of improving physiological capacity to withstand the major insult of surgery. Prehabilitation before GI cancer surgery is currently not widely adopted, and most research has focused on unimodal interventions such as exercise therapy, nutritional supplementation, and hematinic optimization. A review of the existing literature was undertaken to investigate the impact of multimodal prehabilitation programs as a "bundle of care...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29219897/management-of-complex-epithelial-ingrowth-after-laser-in-situ-keratomileusis-using-fibrin-tissue-glue
#5
Lisa Y Chen, Jennifer S Kung, Edward E Manche
OBJECTIVES: To evaluate the efficacy and safety of adjunctive fibrin tissue glue in the treatment of complex epithelial ingrowth after laser in situ keratomileusis (LASIK). METHODS: A retrospective review was performed of 12 eyes in 12 patients treated for clinically significant epithelial ingrowth after LASIK with mechanical debridement of the ingrowth and placement of fibrin tissue glue. Primary outcome measurements including recurrence of ingrowth, visual acuity, and manifest refraction were evaluated at each postoperative examination...
December 5, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29218690/neoadjuvant-volumetric-modulated-arc-therapy-in-rectal-cancer-and-the-correlation-of-pathological-response-with-diffusion-weighted-mri-and-apoptotic-markers
#6
Necla Gurdal, Merdan Fayda, Nijat Alishev, Baris Bakir, Didem Tastekin, Faruk Aykan, Ugur Gezer, Emre Balik, Esra Kaytan Saglam, Ethem Nezih Oral, Mine Gulluoglu, Ahmet Kizir
PURPOSE: In this prospective observational study, we aimed to report the applicability and tolerability of neoadjuvant volumetric modulated arc therapy with simultaneous integrated boost (SIB-VMAT) and concurrent chemotherapy in patients with locally advanced rectal cancer (LARC), and to evaluate the correlation of pathological response with apparent diffusion coefficient (ADC) measurements on diffusion-weighted magnetic resonance imaging (DW-MRI) and apoptotic markers. METHODS: The study enrolled 30 patients with T3 to T4 and/or N+ rectal cancer who preoperatively received SIB-VMAT and concurrent chemotherapy...
December 6, 2017: Tumori
https://www.readbyqxmd.com/read/29217903/regression-of-ophthalmopathic-exophthalmos-in-graves-disease-after-total-thyroidectomy-a-prospective-study-of-a-surgical-series
#7
P R K Bhargav, M Sabaretnam, S Chandra Kumar, S Zwalitha, N Vimala Devi
Autoimmune ophthalmopathy is one of the salient clinical features associated with Graves' disease. Exophthalmos is one of the commonest manifestations of Graves' associated ophthalmopathy. It is reported to regress after thyroidectomy favourably compared to radioiodine or antithyroid drug therapy. In this context, we present our experience based on a surgical series of Graves' disease. This is a prospective study of 15 patients of Graves' disease associated with ophthalmopathic exophthalmos. Preoperative and monthly postoperative evaluation of exophthalmos was done with Hertel's exophthalmometer, apart from documenting lid, extra-ocular muscle and orbital involvement...
December 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29215771/p16-positivity-and-regression-grade-predict-survival-after-neoadjuvant-radiotherapy-of-oscc
#8
Christina Eder-Czembirek, Irene Sulzbacher, Thorsten Fuereder, Edgar Selzer
OBJECTIVES: Survival after preoperative radiotherapy in locally advanced head and neck squamous cell cancer is associated with pathological response. The prognostic importance of p16 expression in these patients has not been established yet. MATERIALS AND METHODS: Ninety-seven oral squamous cell carcinoma patients, treated preoperatively with radiotherapy in combination with chemotherapy or cetxuximab, were included in this retrospective analysis. Survival rates were estimated by the Kaplan-Meyer method...
December 7, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29215395/topical-tacrolimus-as-adjuvant-therapy-to-corticosteroids-in-acute-endothelial-graft-rejection-after-penetrating-keratoplasty-a-randomized-controlled-trial
#9
Mohammad Nasser Hashemian, Golshan Latifi, Reza Ghaffari, Hamed Ghassemi, Mehran Zarei Ghanavati, Seyed-Farzad Mohammadi, Mehdi Yasseri, Mohammad Reza Fallah Tafti, Zahra Fallah Tafti
PURPOSE: To evaluate the efficacy of topical tacrolimus 0.05% as adjuvant therapy to corticosteroids in the treatment of acute endothelial rejection of a penetrating keratoplasty (PKP) graft. METHODS: Patients with the clinical diagnosis of acute endothelial rejection of a PKP graft were randomized into 2 groups-group 1: receiving topical tacrolimus 0.05% as adjuvant therapy to corticosteroid treatment and group 2: receiving only corticosteroid treatment. Main outcome measures were rejection reversal, time to rejection reversal, and recurrence of rejection...
December 5, 2017: Cornea
https://www.readbyqxmd.com/read/29214945/-quality-of-life-and-mental-health-of-patients-with-severe-heart-failure-with-or-without-technical-support-for-the-left-cardiac-ventricle-a-cross-sectional-study
#10
Birte Dahrmann, Jürgen Sindermann, Thomas Geldmacher, Gereon Heuft
Quality of life and mental health of patients with severe heart failure with or without technical support for the left cardiac ventricle - a cross-sectional study Objectives: Chronic heart failure is associated with reduced quality of life (QoL) and poor prognosis. Support via a left ventricular assist device (LVAD) is an alternative to optimised medical management for patients with advanced heart failure. This study evaluated health-related QoL with both therapy options. METHODS: In this consecutive cross-sectional study, patients with LVAD support (n = 50) and patients with optimised medical management (n = 50) were interviewed comprehensively about various domains of QoL, emotional stress, perceived self-efficacy, social support, life satisfaction, and communication...
December 2017: Zeitschrift Für Psychosomatische Medizin und Psychotherapie
https://www.readbyqxmd.com/read/29214640/management-of-head-and-neck-primary-unknown-squamous-cell-carcinoma-using-combined-positron-emission-tomography-computed-tomography-and-transoral-laser-microsurgery
#11
Victoria Kuta, Blair Williams, Matthew Rigby, Robert Hart, Jonathan Trites, Colin MacKay, S Mark Taylor
OBJECTIVES/HYPOTHESIS: The unknown primary of the neck is commonly encountered by the head and neck surgeon. Despite the exhaustive diagnostic tools employed in traditional detection protocols, many unknown primaries are not found, and the patient is subjected to wide-field radiation and chemotherapy during treatment. Localizing the primary tumor has demonstrated therapeutic benefits, improved quality of life, and overall survival. The authors' objective was to determine the efficacy of a new management protocol for unknown primaries of the head and neck...
December 7, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29211302/adoption-of-evidence-based-novel-therapies-in-the-treatment-of-gastric-cancer-a-national-observational-study
#12
Ali A Mokdad, Amna Ali, Adam C Yopp, Patricio M Polanco, Ibrahim Nassour, John C Mansour, Michael A Choti, Rebecca M Minter, Sam C Wang, Matthew R Porembka
BACKGROUND: The adoption of novel and effective gastric cancer therapies into general clinical practice has crucial implications for patient outcomes. The current study explored trends in treatment use and overall survival in patients with gastric cancer in the United States. METHODS: Patients with adenocarcinoma of the gastric cardia and noncardia were identified in the National Cancer Data Base between 2006 and 2014. Tumor stages were divided into early (IA), locally advanced (IB-IIIC), and metastatic (IV) stage...
December 6, 2017: Cancer
https://www.readbyqxmd.com/read/29209927/hydroxocobalamin-for-the-treatment-of-cardiac-surgery-associated-vasoplegia-a-case-series
#13
Pranav R Shah, Penny S Reynolds, Nirvik Pal, Daniel Tang, Harry McCarthy, Bruce D Spiess
PURPOSE: Vasoplegia is a clinical syndrome marked by severe arteriolar vasodilatation, hypotension, and low systemic vascular resistance refractory to multiple vasopressor treatment. We report our experience with hydroxocobalamin (B12) infusion as a potential rescue adjunct for refractory vasoplegia during cardiopulmonary bypass (CPB). METHODS: We performed a retrospective chart review of 33 patients undergoing cardiac surgery between 1 January 2013 and 31 December 2015, who were given intravenous B12 for refractory hypotension during, or immediately following, CPB...
December 5, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29207229/-bilirubin-removal-with-coupled-plasma-filtration-and-adsorption-in-patients-affected-by-hilar-cholangiocarcinoma
#14
Walter De Simone, Francesco Crafa, Adele Noviello, Francesco Esposito, Bruno Zito, Rocco Manganelli, Antonella De Simone, Luigi Covotta, Giuseppe Palladino, Emanuele De Simone
Background: Patients affected by hilar cholangiocarcinoma are eligible for surgery only in the 20-30% of the cases and postoperative mortality is 40-50%. Many specialists are involved in the treatment of this disease, like surgeons, gastroenterologists, oncologists and radiotherapists. Recent studies have shown that preoperative bilirubinaemia is a predictor of morbidity and mortality after surgery. Coupled Plasma Filtration and Adsorption (CPFA) is a blood purification extracorporeal therapy recommended for sepsis and able to reduce bilirubinaemia...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29205363/risk-of-peritoneal-metastases-in-patients-who-had-negative-peritoneal-staging-and-received-therapy-for-localized-gastric-adenocarcinoma
#15
Dilsa Mizrak Kaya, Graciela M Nogueras-González, Kazuto Harada, Fatemeh G Amlashi, Sinchita Roy-Chowdhuri, Jeannelyn S Estrella, Prajnan Das, Jeffrey H Lee, Brian Weston, Manoop S Bhutani, Aurelio Matamoros, Irene Thomas, Quan Lin, Brian D Badgwell, Jaffer A Ajani
BACKGROUND: Positive peritoneal cytology (+PCyt) or gross carcinomatosis (GPC) carries a poor prognosis. Laparoscopic staging to detect +PCyt/GPC is recommended for all ≥T1b gastric adenocarcinoma (GAC). The natural history of patients with GAC who have baseline -PCyt and then undergo multimodality therapy is not well documented, particularly for the risk of subsequent GPC. METHODS: We identified 238 GAC patients with baseline -PCyt who were followed for the development of peritoneal carcinomatosis (PC)...
December 4, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29204586/transoral-robotic-surgery-for-obstructive-sleep-apnea-syndrome-principles-and-technique
#16
Claudio Vicini, Filippo Montevecchi, Riccardo Gobbi, Andrea De Vito, Giuseppe Meccariello
Objective: The present study is a review of transoral robotic surgery (TORS) for the treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods: The review presents the experience of the robotic center that developed the technique with regards to patient selection, surgical method, and post-operative care. In addition, the review provides results of a systematic review and meta-analysis of the complications and clinical outcomes of TORS when applied in the management of OSAHS...
June 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29202879/the-effect-of-prone-and-supine-treatment-positions-for-the-pre-operative-treatment-of-rectal-cancer-on-organ-at-risk-sparing-and-setup-reproducibility-using-volumetric-modulated-arc-therapy
#17
Anthony Kim, Aliaksandr Karotki, Joe Presutti, Glen Gonzales, Shun Wong, William Chu
BACKGROUND AND PURPOSE: To compare organ-at-risk doses and setup reproducibility using the prone and supine orientations in volumetric modulated arc therapy (VMAT) for rectal cancer. MATERIALS AND METHODS: Seventeen consecutive rectal cancer patients undergoing preoperative radiation were selected and setup in either the prone (N = 8) or supine (N = 9) position. All patients were treated using posteriorly-applied VMAT. Bladder and small bowel dose and cone beam CT (CBCT) reproducibility metrics were retrospectively collected...
December 5, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29202490/-metastasation-of-cutaneous-squamous-cell-carcinoma-in-the-ent-area
#18
Alexander Dellweg, Thomas Mantei
Objectives Our aim was to investigate the metastasis behavior and its prognostic Factor for Survival, with our clinical data. Materials and methods This retrospective study included 29 Caucasians, with a squamous cell carcinoma of the skin in the head and neck region, at our tertiary clinic between 2004 and 2016. All Patients received a Tumorresection and Neckdissection. We used either Ultrasound or Computer-Tomography (conventional or PET-CT) for our preoperative Staging and the Follow-up. The Patients were classified according to metastatic behavior and the corresponding survival rates were determined...
December 4, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29201178/analgesic-therapy-improves-arterial-endothelial-function-following-non-cardiovascular-surgery-a-randomized-placebo-controlled-trial
#19
Meng-Jun Wu, Meng-Chang Yang, Long-Qing Ran, Su-Mei Wei, Wen-Lai Zhou, Yong-Sheng Gou, Hai Yu
Pain subsequent to non-cardiac surgery may affect the endothelial function, which in turn contributes to myocardial injury (MI). The present study examined whether effective pain control is able to improve the postoperative endothelial function. Patients (n=160) undergoing laparoscopic cholecystectomy were randomly assigned into two groups, treated with tramadol analgesic or saline (placebo) following surgery. On preoperative day 1 (baseline) and postoperatively at 2 h, 1 day and 5 days, pain was assessed on a visual analogue scale (VAS), and B-mode ultrasound was used to measure brachial endothelium-dependent flow-mediated dilation (FMD) and nitroglycerin-induced dilation...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29200869/preoperative-prognostic-nutritional-index-and-nomogram-predicting-recurrence-free-survival-in-patients-with-primary-non-muscle-invasive-bladder-cancer-without-carcinoma-in-situ
#20
Jianfeng Cui, Shouzhen Chen, Qiyu Bo, Shiyu Wang, Ning Zhang, Meng Yu, Wenfu Wang, Jie Han, Yaofeng Zhu, Benkang Shi
Background and objectives: Among the cancers of the urogenital system, bladder cancer is ranked second both in incidence and mortality, and hence, a more accurate estimate of the prognosis for individual patients with non-muscle-invasive bladder cancer (NMIBC) is urgently needed. Prognostic nutritional index (PNI) which is based on serum albumin levels and peripheral lymphocyte count has been confirmed to have prognostic value in various cancers. The aim of this study was to clarify the prognostic value of PNI in patients with NMIBC...
2017: OncoTargets and Therapy
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