keyword
https://read.qxmd.com/read/38182296/regulators-of-necroinflammation-in-acute-kidney-injury
#21
JOURNAL ARTICLE
Hans-Joachim Anders, Joachim Andrassy, Julia Lichtnekert
Interleukin (IL)-22 is unique among the ILs as it elicits direct effects on kidney epithelia and regulates cell survival in a context-dependent manner. Studies published in Kidney International and other journals demonstrate opposing roles of IL-22 (e.g., in models of acute kidney injury). In the early necroinflammation phase of acute kidney injury, IL-22 promotes tubular cell death, whereas it enhances the proliferation and regeneration of epithelial barrier function in the healing phase of injured tubules...
January 2024: Kidney International
https://read.qxmd.com/read/38163633/fibroblastic-reticular-cell-derived-exosomes-are-a-promising-therapeutic-approach-for-septic-acute-kidney-injury
#22
JOURNAL ARTICLE
Yiming Li, Chang Hu, Pan Zhai, Jing Zhang, Jun Jiang, Jinmeng Suo, Bo Hu, Jing Wang, Xiaocheng Weng, Xiang Zhou, Timothy R Billiar, John A Kellum, Meihong Deng, Zhiyong Peng
Sepsis-induced acute kidney injury (S-AKI) is highly lethal, and effective drugs for treatment are scarce. Previously, we reported the robust therapeutic efficacy of fibroblastic reticular cells (FRCs) in sepsis. Here, we demonstrate the ability of FRC-derived exosomes (FRC-Exos) to improve C57BL/6 mouse kidney function following cecal ligation and puncture-induced sepsis. In vivo imaging confirmed that FRC-Exos homed to injured kidneys. RNA-Seq analysis of FRC-Exo-treated primary kidney tubular cells (PKTCs) revealed that FRC-Exos influenced PKTC fate in the presence of lipopolysaccharide (LPS)...
December 30, 2023: Kidney International
https://read.qxmd.com/read/38152048/network-pharmacology-and-molecular-docking-of-endogenous-active-metabolites-in-diabetic-kidney-disease
#23
JOURNAL ARTICLE
Xinmiao Xie, Yanzhe Wang, Sijia Chen, Yuyuan Liu, Fengqin Li, Chuchu Zeng, Ling Zhang, Xiaoxia Wang
OBJECTIVES: Network pharmacology and molecular docking were used to predict endogenous active metabolites with protective effects in diabetic kidney disease (DKD). METHODS: We utilized metabolomics to screen differentially expressed metabolites in kidney tissues of mice with type 2 DKD and predicted potential targets using relevant databases. The interaction network between endogenous active metabolites and target proteins was established by integrating differentially expressed metabolites and proteins associated with DKD identified through proteomics...
2023: Renal Failure
https://read.qxmd.com/read/38106319/assessment-of-rhabdomyolysis-induced-acute-kidney-injury-with-chemical-exchange-saturation-transfer-magnetic-resonance-imaging
#24
JOURNAL ARTICLE
Qianqian Zhang, Quan Tao, Yuanyao Xie, Zelong Chen, Erdmann Seeliger, Thoralf Niendorf, Wufan Chen, Yanqiu Feng
BACKGROUND: Rhabdomyolysis (RM)-induced acute kidney injury (AKI) is a common renal disease with low survival rate and inadequate prognosis. In this study, we investigate the feasibility of chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) for assessing the progression of RM-induced AKI in a mouse model. METHODS: AKI was induced in C57BL/6J mice via intramuscular injection of 7.5 mL/kg glycerol (n=30). Subsequently, serum creatinine (SCr), blood urea nitrogen (BUN), and hematoxylin-eosin (HE) and Masson staining, were performed...
December 1, 2023: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38091407/analysis-of-the-human-kidney-transcriptome-and-plasma-proteome-identifies-markers-of-proximal-tubule-maladaptation-to-injury
#25
JOURNAL ARTICLE
Yumeng Wen, Emily Su, Leyuan Xu, Steven Menez, Dennis G Moledina, Wassim Obeid, Paul M Palevsky, Sherry G Mansour, Prasad Devarajan, Lloyd G Cantley, Patrick Cahan, Chirag R Parikh
Acute kidney injury (AKI) is a major risk factor for long-term adverse outcomes, including chronic kidney disease. In mouse models of AKI, maladaptive repair of the injured proximal tubule (PT) prevents complete tissue recovery. However, evidence for PT maladaptation and its etiological relationship with complications of AKI is lacking in humans. We performed single-nucleus RNA sequencing of 120,985 nuclei in kidneys from 17 participants with AKI and seven healthy controls from the Kidney Precision Medicine Project...
December 13, 2023: Science Translational Medicine
https://read.qxmd.com/read/38035992/dihydromyricetin-protects-against-gentamicin-induced-nephrotoxicity-via-upregulation-of-renal-sirt3-and-pax2
#26
JOURNAL ARTICLE
Asmaa I Matouk, Eman M Awad, Amr A Kamel, Sara M N Abdelhafez, Osama Fahmi, Mohamed A El-Moselhy, Ashraf B Abdel-Naim, Aliaa Anter
AIM: Gentamicin-induced nephrotoxicity limits its widespread use as an effective antibacterial agent. Oxidative stress, inflammatory cytokines and apoptotic cell death are major participants in gentamicin-induced nephrotoxicity. We therefore, investigated whether dihydromyricetin (DHM), the antioxidant and anti-inflammatory flavonoid, could protect against the nephrotoxic effects of gentamicin. METHODS: Male Wistar rats administrated gentamicin (100 mg/kg/day, i...
November 28, 2023: Life Sciences
https://read.qxmd.com/read/38027853/network-pharmacology-and-in-vitro-experimental-verification-to-reveal-the-mechanism-of-astragaloside-iv-against-kidney-ischemia-reperfusion-injury
#27
JOURNAL ARTICLE
Yan Guo, Jinfu Wang, Yanjie Hua, Mengya Jiang, Wanyue Xu, Yanpeng Shi, Jiehong Yang, Haitong Wan, Ruchun Yang
Ischemic acute kidney injury (AKI) is a prevalent disorder among hospitalized patients worldwide. Astragaloside IV (AS-IV) has been shown to protect against ischemic AKI. However, the specific effects and mechanisms of AS-IV on alleviating kidney ischemia-reperfusion (I/R) injury remain unclear. The objective of this research was to elucidate the regulatory targets and mechanisms through which AS-IV protects kidney I/R injury. A combination of network pharmacology, molecular docking, molecular dynamics (MD) simulation, pharmacodynamic study and Western blot were employed to explore the underlying mechanisms...
November 2023: Heliyon
https://read.qxmd.com/read/38024191/prehospital-management-of-earthquake-crush-injuries-a-collective-review
#28
JOURNAL ARTICLE
Fikri M Abu-Zidan, Kamal Idris, Arif Alper Cevik
Earthquakes are natural disasters which can destroy the rural and urban infrastructure causing a high toll of injuries and death without advanced notice. We aim to review the prehospital medical management of earthquake crush injuries in the field. PubMed was searched using general terms including rhabdomyolysis, crush injury, and earthquake in English language without time restriction. Selected articles were critically evaluated by three experts in disaster medicine, emergency medicine, and critical care. The medical response to earthquakes includes: (1) search and rescue; (2) triage and initial stabilization; (3) definitive care; and (4) evacuation...
2023: Turkish Journal of Emergency Medicine
https://read.qxmd.com/read/38022581/sars-cov-2-n-protein-induced-acute-kidney-injury-in-diabetic-db-db-mice-is-associated-with-a-mincle-dependent-m1-macrophage-activation
#29
JOURNAL ARTICLE
Wenjing Wu, Wenbiao Wang, Liying Liang, Junzhe Chen, Sifan Sun, Biao Wei, Yu Zhong, Xiao-Ru Huang, Jian Liu, Xiaoqin Wang, Xueqing Yu, Hui-Yao Lan
"Cytokine storm" is common in critically ill COVID-19 patients, however, mechanisms remain largely unknown. Here, we reported that overexpression of SARS-CoV-2 N protein in diabetic db/db mice significantly increased tubular death and the release of HMGB1, one of the damage-associated molecular patterns (DAMPs), to trigger M1 proinflammatory macrophage activation and production of IL-6, TNF-α, and MCP-1 via a Mincle-Syk/NF-κB-dependent mechanism. This was further confirmed in vitro that overexpression of SARS-CoV-2 N protein caused the release of HMGB1 from injured tubular cells under high AGE conditions, which resulted in M1 macrophage activation and production of proinflammatory cytokines via a Mincle-Syk/NF-κB-dependent mechanism...
2023: Frontiers in Immunology
https://read.qxmd.com/read/38022500/dynamics-of-necroptosis-in-kidney-ischemia-reperfusion-injury
#30
JOURNAL ARTICLE
Aspasia Pefanis, Anjan K Bongoni, Jennifer L McRae, Evelyn J Salvaris, Nella Fisicaro, James M Murphy, Francesco L Ierino, Peter J Cowan
Necroptosis, a pathway of regulated necrosis, involves recruitment and activation of RIPK1, RIPK3 and MLKL, leading to cell membrane rupture, cell death and release of intracellular contents causing further injury and inflammation. Necroptosis is believed to play an important role in the pathogenesis of kidney ischemia-reperfusion injury (IRI). However, the dynamics of necroptosis in kidney IRI is poorly understood, in part due to difficulties in detecting phosphorylated MLKL (pMLKL), the executioner of the necroptosis pathway...
2023: Frontiers in Immunology
https://read.qxmd.com/read/38020860/pediatric-renal-trauma-17-years-of-experience-at-a-major-scandinavian-trauma-center
#31
JOURNAL ARTICLE
Amund Hovengen Ringen, André Fatland, Nils Oddvar Skaga, Christine Gaarder, Paal Aksel Naess
BACKGROUND: Children are at increased risk of renal injuries from blunt trauma due to their anatomic constitution. The kidney is injured in 5-20% of pediatric patients with blunt abdominal trauma. During the last decades, the management of pediatric renal injuries has evolved toward non-operative management (NOM) unless the patient is hemodynamically compromised. The aim of the present study was to assess contemporary treatment strategies and evaluate outcomes in pediatric patients with renal injuries admitted to a major Scandinavian trauma center...
2023: Trauma Surgery & Acute Care Open
https://read.qxmd.com/read/37999512/renocardiac-effects-of-p-cresyl-sulfate-administration-in-acute-kidney-injury-induced-by-unilateral-ischemia-and-reperfusion-injury-in-vivo
#32
JOURNAL ARTICLE
Carlos Alexandre Falconi, Fernanda Fogaça-Ruiz, Jéssica Verônica da Silva, Raquel Silva Neres-Santos, Carmen Lucía Sanz, Lia Sumie Nakao, Andréa Emília Marques Stinghen, Carolina Victoria Cruz Junho, Marcela Sorelli Carneiro-Ramos
The precise mechanisms underlying the cardiovascular complications due to acute kidney injury (AKI) and the retention of uremic toxins like p-cresyl sulfate (PCS) remain incompletely understood. The objective of this study was to evaluate the renocardiac effects of PCS administration in animals subjected to AKI induced by ischemia and reperfusion (IR) injury. C57BL6 mice were subjected to distinct protocols: (i) administration with PCS (20, 40, or 60 mg/L/day) for 15 days and (ii) AKI due to unilateral IR injury associated with PCS administration for 15 days...
November 10, 2023: Toxins
https://read.qxmd.com/read/37979155/regulatory-networks-of-circrna-centred-cernas-in-sepsis-induced-acute-kidney-injury
#33
JOURNAL ARTICLE
Tongtong Ma, Junjie Wu, Zhongqing Chen
Sepsis is the primary cause of acute kidney injury (AKI) and is associated with high mortality rates. Growing evidence suggests that noncoding RNAs are vitally involved in kidney illnesses, whereas the role of circular RNAs (circRNAs) in sepsis-induced AKI (SAKI) remains largely unknown. In this present study, caecal ligation and puncture (CLP) in mice was performed to establish an SAKI model. The expression of circRNAs and mRNAs was analysed using circRNA microarray or next-generation sequencing. The results revealed that the expressions of 197 circRNAs and 2509 mRNAs were dysregulated...
December 2023: Epigenetics: Official Journal of the DNA Methylation Society
https://read.qxmd.com/read/37978868/autophagy-activates-egr1-via-mapk-erk-to-induce-fgf2-in-renal-tubular-cells-for-fibroblast-activation-and-fibrosis-during-maladaptive-kidney-repair
#34
JOURNAL ARTICLE
Man J Livingston, Ming Zhang, Sang-Ho Kwon, Jian-Kang Chen, Honglin Li, Santhakumar Manicassamy, Zheng Dong
Macroautophagy/autophagy contributes to maladaptive kidney repair by inducing pro-fibrotic factors such as FGF2 (fibroblast growth factor 2), but the underlying mechanism remains elusive. Here, we show that EGR1 (early growth response 1) was induced in injured proximal tubules after ischemic acute kidney injury (AKI) and this induction was suppressed by autophagy deficiency in inducible, renal tubule-specific atg7 (autophagy related 7) knockout (iRT- atg7 KO) mice. In cultured proximal tubular cells, TGFB1 (transforming growth factor beta 1) induced EGR1 and this induction was also autophagy dependent...
November 18, 2023: Autophagy
https://read.qxmd.com/read/37958550/exosomes-highlight-future-directions-in-the-treatment-of-acute-kidney-injury
#35
REVIEW
Xiaoyu Zhang, Jing Wang, Jing Zhang, Yuwei Tan, Yiming Li, Zhiyong Peng
Acute kidney injury (AKI) is a severe health problem associated with high morbidity and mortality rates. It currently lacks specific therapeutic strategies. This review focuses on the mechanisms underlying the actions of exosomes derived from different cell sources, including red blood cells, macrophages, monocytes, mesenchymal stem cells, and renal tubular cells, in AKI. We also investigate the effects of various exosome contents (such as miRNA, lncRNA, circRNA, mRNA, and proteins) in promoting renal tubular cell regeneration and angiogenesis, regulating autophagy, suppressing inflammatory responses and oxidative stress, and preventing fibrosis to facilitate AKI repair...
October 25, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37953144/predictors-of-oliguria-in-post-traumatic-acute-kidney-injury
#36
JOURNAL ARTICLE
William B Risinger, Samuel J Pera, Kelsey E Cage, Matthew V Benns, Nicholas A Nash, Matthew C Bozeman, Jamie C Coleman, Glen A Franklin, Keith R Miller, Jason W Smith, Brian G Harbrecht
BACKGROUND: Acute kidney injury is classified by urine output into non-oliguric and oliguric variants. Non-oliguric acute kidney injury has lower morbidity and mortality and accounts for up to 64% of acute kidney injury in hospitalized patients. However, the incidence of non-oliguric acute kidney injury in the trauma population and whether the 2 variants of acute kidney injury share the same risk factors is unknown. We hypothesized that oliguria would be present in the majority of acute kidney injury in severely injured trauma patients and that unique risk factors would predispose patients to the development of oliguria...
November 10, 2023: Surgery
https://read.qxmd.com/read/37948276/legal-performance-enhancing-drugs-alter-course-and-treatment-of-rhabdomyolysis-induced-acute-kidney-injury
#37
JOURNAL ARTICLE
Jessica F Hebert, Mahaba B Eiwaz, Megan N Nickerson, Adam C Munhall, Akash A Pai, Tahnee Groat, Nicole K Andeen, Michael P Hutchens
INTRODUCTION: Rhabdomyolysis-induced acute kidney injury (RIAKI) can interrupt physical training and increase mortality in injured warfighters. The legal performance-enhancing drugs caffeine and ibuprofen, which can cause renal injury, are widely used by service members. Whether caffeine or ibuprofen affects RIAKI is unknown. Cilastatin treatment was recently identified as an experimental treatment to prevent RIAKI at injury. To determine potential interacting factors in RIAKI treatment, we test the hypothesis that caffeine and ibuprofen worsen RIAKI and interfere with treatment...
November 8, 2023: Military Medicine
https://read.qxmd.com/read/37942584/ascorbate-protects-human-kidney-organoids-from-damage-induced-by-cell-free-hemoglobin
#38
JOURNAL ARTICLE
Julie Bejoy, Justin M Farry, Eddie S Qian, Curtis H Dearing, Lorraine B Ware, Julie A Bastarache, Lauren E Woodard
Sepsis-associated acute kidney injury is associated with high morbidity and mortality in critically ill patients. Cell-free hemoglobin (CFH) is released into the circulation of patients with severe sepsis and the levels of CFH are independently associated with mortality. CFH treatment increased cytotoxicity in the human tubular epithelial cell line HK-2. To better model the intact kidney, we cultured human kidney organoids derived from induced pluripotent stem cells. We treated human kidney organoids grown by both three-dimensional (3D) and transwell protocols with CFH for 48 hours...
November 9, 2023: Disease Models & Mechanisms
https://read.qxmd.com/read/37918364/endotoxemia-correlates-with-kidney-function-and-length-of-stay-in-critically-ill-patients
#39
JOURNAL ARTICLE
Sian E Piret, Sobia Khan, Fabliha Fairuz, Samaneh Gholami, Merin Davis, Chang Kyung Kim, Melissa Espinoza, Debra Foster, John A Kellum, Sahar Ahmad, Andreas P Kalogeropoulos, Sandeep K Mallipattu
INTRODUCTION: Endotoxin is a key driver of sepsis, which frequently causes acute kidney injury (AKI). However, endotoxins may also be found in non-bacteremic critically ill patients, likely from intestinal translocation. Preclinical models show that endotoxins can directly injure the kidneys, and in COVID-19 patients, endotoxemia correlated with AKI. We sought to determine correlations between endotoxemia and kidney and hospital outcomes in a broad group of critically ill patients. METHODS: In this single-center, serial prospective study, 124 predominantly Caucasian adult patients were recruited within 48 h of admission to Stony Brook University Hospital Intensive Care Unit (ICU)...
November 2, 2023: Blood Purification
https://read.qxmd.com/read/37908721/tet1-deficiency-exacerbates-oxidative-stress-in-acute-kidney-injury-by-regulating-superoxide-dismutase
#40
JOURNAL ARTICLE
Yu Fan, Yangmian Yuan, Mingrui Xiong, Muchuan Jin, Donge Zhang, Dong Yang, Chengyu Liu, Robert B Petersen, Kun Huang, Anlin Peng, Ling Zheng
Rationale: Increased methylation of key genes has been observed in kidney diseases, suggesting that the ten-eleven translocation (Tet) methyl-cytosine dioxygenase family as well as 5mC oxidation may play important roles. As a member of the Tet family, the role of Tet1 in acute kidney injury (AKI) remains unclear. Methods: Tet1 knockout mice, with or without tempol treatment, a scavenger of reactive oxygen species (ROS), were challenged with ischemia and reperfusion (I/R) injury or unilateral ureteral obstruction (UUO) injury...
2023: Theranostics
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