Sian E Piret, Sobia Khan, Fabliha Fairuz, Samaneh Gholami, Merin Davis, Chang Kyung Kim, Melissa Espinoza, Debra Foster, John A Kellum, Sahar Ahmad, Andreas P Kalogeropoulos, Sandeep K Mallipattu
INTRODUCTION: Endotoxin is a key driver of sepsis, which frequently causes acute kidney injury (AKI). However, endotoxins may also be found in non-bacteremic critically ill patients, likely from intestinal translocation. Preclinical models show that endotoxins can directly injure the kidneys, and in COVID-19 patients, endotoxemia correlated with AKI. We sought to determine correlations between endotoxemia and kidney and hospital outcomes in a broad group of critically ill patients. METHODS: In this single-center, serial prospective study, 124 predominantly Caucasian adult patients were recruited within 48 h of admission to Stony Brook University Hospital Intensive Care Unit (ICU)...
November 2, 2023: Blood Purification