keyword
https://read.qxmd.com/read/38482555/tnik-depletion-induces-inflammation-and-apoptosis-ininjured-renal-proximal-tubule-epithelial-cells
#1
JOURNAL ARTICLE
Shayna T J Bradford, Haojia Wu, Yuhei Kirita, Changfeng Chen, Nicole P Malvin, Yasuhiro Yoshimura, Yoshiharu Muto, Benjamin D Humphreys
In the aftermath of acute kidney injury (AKI), surviving proximal tubule epithelia repopulate injured tubules to promote repair. However, a portion of cells fail to repair (termed Failed Repair Proximal Tubule Cells, FR-PTCs) and exert ongoing proinflammatory and profibrotic effects. To better understand the molecular drivers of the FR-PTC state, we reanalyzed a mouse ischemia-reperfusion injury single nucleus RNA-sequencing (snRNA-seq) atlas to identify Traf2 and Nck Interacting Kinase, Tnik, to be exclusively expressed in FR-PTCs, but not in healthy or acutely injured proximal tubules post AKI (2 and 6 weeks) in mice...
March 14, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38471364/foxa1-driven-pathways-exacerbate-radiotherapy-induced-kidney-injury-in-colorectal-cancer
#2
JOURNAL ARTICLE
Minhai Zhang, Jingyuan Yang, Guodong Liang, Huiqiong Yuan, Yanni Wu, Li Li, Tao Yu, Yuling Zhang, Jingfeng Wang
OBJECTIVE: This study aimed to investigate the role of FOXA1 in acute kidney injury (AKI) induced by radiotherapy in colorectal cancer. Although FOXA1 is known to be aberrantly expressed in malignant tumors, its contribution to AKI remains unclear. This study aimed to explore the involvement of FOXA1 in AKI induced by radiotherapy in colorectal cancer and its influence on the regulation of downstream target genes. METHODS: Firstly, a transcriptome analysis was performed on mice to establish a radiation-induced AKI model, and qPCR was used to determine the expression of FOXA1 in renal cell injury models induced by X-ray irradiation...
March 11, 2024: International Immunopharmacology
https://read.qxmd.com/read/38464306/sterile-kidney-tissue-injury-induces-neutrophil-swarming-in-lung-alveolar-capillaries
#3
Yohei Komaru, Liang Ning, Carine Lama, Anusha Suresh, Eirini Kefaloyianni, Mark J Miller, Andreas Herrlich
Sterile tissue injury, such as by acute kidney injury, is common in the clinic and frequently associated with respiratory compromise and hypoxemia. We previously described signaling components released by the injured kidney that drive a remote inflammatory response in the lung. How this caused the resultant hypoxemia remained unclear. Here, we report that sterile kidney tissue injury induces rapid intravascular "neutrophil train" formation in lung capillaries, a novel form of neutrophil swarming. Rapid swarming is enhanced by decreased deformability of circulating neutrophils that impedes their lung capillary passage...
March 2, 2024: bioRxiv
https://read.qxmd.com/read/38460295/initial-renal-replacement-therapy-rrt-modality-associates-with-90-day-postdischarge-rrt-dependence-in-critically-ill-aki-survivors
#4
JOURNAL ARTICLE
Jay L Koyner, Rachel H Mackey, Jorge Echeverri, Ning A Rosenthal, Leslie A Carabuena, Daniel Bronson-Lowe, Kai Harenski, Javier A Neyra
PURPOSE: Real-world comparison of RRT modality on RRT dependence at 90 days postdischarge among ICU patients discharged alive after RRT for acute kidney injury (AKI). METHODS: Using claims-linked to US hospital discharge data (Premier PINC AI Healthcare Database [PHD]), we compared continuous renal replacement therapy (CRRT) vs. intermittent hemodialysis (IHD) for AKI in adult ICU patients discharged alive from January 1, 2018 to June 30, 2021. RRT dependence at 90 days postdischarge was defined as ≥2 RRT treatments in the last 8 days...
March 8, 2024: Journal of Critical Care
https://read.qxmd.com/read/38444605/lineage-tracing-reveals-transient-phenotypic-adaptation-of-tubular-cells-during-acute-kidney-injury
#5
JOURNAL ARTICLE
Marc Buse, Mingbo Cheng, Vera Jankowski, Michaela Lellig, Viktor Sterzer, Thiago Strieder, Katja Leuchtle, Ina V Martin, Claudia Seikrit, Paul Brinkkoettter, Giuliano Crispatzu, Jürgen Floege, Peter Boor, Timotheus Speer, Rafael Kramann, Tammo Ostendorf, Marcus J Moeller, Ivan G Costa, Eleni Stamellou
Tubular injury is the hallmark of acute kidney injury (AKI) with a tremendous impact on patients and health-care systems. During injury, any differentiated proximal tubular cell (PT) may transition into a specific injured phenotype, so-called "scattered tubular cell" (STC)-phenotype. To understand the fate of this specific phenotype, we generated transgenic mice allowing inducible, reversible, and irreversible tagging of these cells in a murine AKI model, the unilateral ischemia-reperfusion injury (IRI). For lineage tracing, we analyzed the kidneys using single-cell profiling during disease development at various time points...
March 15, 2024: IScience
https://read.qxmd.com/read/38431215/multi-omics-and-imaging-mass-cytometry-characterization-of-human-kidneys-to-identify-pathways-and-phenotypes-associated-with-impaired-kidney-function
#6
JOURNAL ARTICLE
Evans O Asowata, Simone Romoli, Rebecca Sargeant, Jennifer Y Tan, Scott Hoffmann, Margaret M Huang, Krishnaa T Mahbubani, Fynn N Krause, Daniel Jachimowicz, Rasmus Agren, Albert Koulman, Benjamin Jenkins, Barbara Musial, Julian L Griffin, Magnus Soderberg, Stephanie Ling, Pernille B L Hansen, Kourosh Saeb-Parsy, Kevin J Woollard
Despite the recent advances in our understanding of the role of lipids, metabolites and related enzymes in mediating kidney injury, there is limited integrated multi-omics data identifying potential metabolic pathways driving impaired kidney function. The limited availability of kidney biopsies from living donors with acute kidney injury has remained a major constraint. Here, we validated the use of deceased transplant donor kidneys as a good model to study acute kidney injury in humans and characterized these kidneys using imaging and multi-omics approaches...
February 29, 2024: Kidney International
https://read.qxmd.com/read/38401323/renal-vein-thrombosis-in-the-course-of-non-operative-treatment-of-kidney-trauma-a-rare-case-report
#7
João Henrique Fonseca Nascimento, André Bouzas de Andrade, Márcio Rivison Silva Cruz, Roberto Valente Filho, André Gusmão-Cunha, Gabriel Schnitman
INTRODUCTION: Venous thromboembolism is widely recognized as a life-threatening complication in trauma, yet renal vein thrombosis (RVT) following trauma is particularly rare. PRESENTATION OF CASE: We report a case of a 67-year-old man who was brought to the emergency department after falling down a 14-step staircase at home which presented right kidney trauma (parenchyma laceration with a perirenal hematoma) on computed tomography, and hematuria. Considering the patient's hemodynamic stability, a non-operative treatment was initiated, and the patient was referred to the intensive care unit for close observation...
February 22, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38386758/sox9-switch-links-regeneration-to-fibrosis-at-the-single-cell-level-in-mammalian-kidneys
#8
JOURNAL ARTICLE
Shikhar Aggarwal, Zhanxiang Wang, David Rincon Fernandez Pacheco, Anna Rinaldi, Alex Rajewski, Jasper Callemeyn, Elisabet Van Loon, Baptiste Lamarthée, Ambart Ester Covarrubias, Jean Hou, Michifumi Yamashita, Haruhiko Akiyama, S Ananth Karumanchi, Clive N Svendsen, Paul W Noble, Stanley C Jordan, Joshua J Breunig, Maarten Naesens, Pietro E Cippà, Sanjeev Kumar
The steps governing healing with or without fibrosis within the same microenvironment are unclear. After acute kidney injury (AKI), injured proximal tubular epithelial cells activate SOX9 for self-restoration. Using a multimodal approach for a head-to-head comparison of injury-induced SOX9 lineages, we identified a dynamic SOX9 switch in repairing epithelia. Lineages that regenerated epithelia silenced SOX9 and healed without fibrosis (SOX9on-off ). By contrast, lineages with unrestored apicobasal polarity maintained SOX9 activity in sustained efforts to regenerate, which were identified as a SOX9on-on Cadherin6pos cell state...
February 23, 2024: Science
https://read.qxmd.com/read/38360398/renal-ischemia-and-reperfusion-impact-the-purinergic-signaling-in-a-vascular-bed-distant-from-the-injured-site
#9
JOURNAL ARTICLE
Jeferson Stabile, Raquel Silva Neres-Santos, Isabela Dorta Molina Hernandes, Carolina Victória Cruz Junho, Geovane Felippe Alves, Isabella Cardoso Silva, Marcela Sorelli Carneiro-Ramos, Cristina Ribas Fürstenau
AIMS: Acute kidney injury (AKI) is a public health problem and represents a risk factor for cardiovascular diseases (CVD) and vascular damage. This study aimed to investigate the impact of AKI on purinergic components in mice aorta. MAIN METHODS: The kidney ischemia was achieved by the occlusion of the left kidney pedicle for 60 min, followed by reperfusion for 8 (IR8) and 15 (IR15) days. Renal function was assessed through biochemical assays, while gene expression levels were evaluated by RT-qPCR...
February 13, 2024: Biochimie
https://read.qxmd.com/read/38353655/sensing-dying-cells-in-health-and-disease-the-importance-of-kidney-injury-molecule-1
#10
JOURNAL ARTICLE
Elena Tutunea-Fatan, Shabitha Arumugarajah, Rita S Suri, Cassandra R Edgar, Ingrid Hon, Jimmy D Dikeakos, Lakshman Gunaratnam
Kidney Injury Molecule-1 (KIM-1), also known as T cell immunoglobulin and mucin domain-1 (TIM-1), is a widely recognized biomarker for acute kidney injury, but its biological function is less appreciated. KIM-1/TIM-1 belongs to the TIM family of conserved transmembrane proteins which bear the characteristic six-cysteine immunoglobulin-like (IgV) domain. The latter enables binding of KIM-1/TIM-1 to its natural ligand, phosphatidylserine, expressed on the surface of apoptotic cells and necrotic cells. KIM-1/TIM-1 is expressed in a variety of tissues and plays fundamental roles in regulating sterile inflammation and adaptive immune responses...
February 14, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38335143/ultrasmall-nanoparticles-regulate-immune-microenvironment-by-activating-il-33-st2-to-alleviate-renal-ischemia-reperfusion-injury
#11
JOURNAL ARTICLE
Liyao Xu, Zhaoyu Xing, Jiaxin Yuan, Yaobao Han, Zhilin Jiang, Mengxiao Han, Xianao Hou, Wei Xing, Zhen Li
Renal ischemia-reperfusion injury (IRI) is a common disease with high morbidity and mortality. Renal IRI can cause the disorder of immune microenvironment and reprograming the immune microenvironment to alleviate excessive inflammatory response is crucial for its treatment. Cytokine IL-33 can improve the immune inflammatory microenvironment by modulating both innate and adaptive immune cells, and serve as an important target for modulating immune microenvironment of renal IRI. Herein, we report that bilobetin-functionalized ultra-small Cu2-x Se nanoparticles (i...
February 9, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38327222/pediatric-kidney-care-experience-after-the-2023-turkey-syria-earthquake
#12
JOURNAL ARTICLE
Sevcan A Bakkaloğlu, Ali Delibaş, Serra Sürmeli Döven, Sevgin Taner, Sevgi Yavuz, Gökçen Erfidan, Esra Danacı Vatansever, Fatma Aynacı, Kenan Yilmaz, Mehmet Taşdemir, Okan Akacı, Nurver Akıncı, Serçin Güven, Neslihan Çiçek, Ismail Dursun, Emre Keleşoğlu, Muhammet Sancaktar, Demet Alaygut, Seha Saygılı, Önder Yavaşcan, Alev Yılmaz, Kaan Gülleroğlu, Pelin Ertan, Belde Kasap Demir, Hakan Poyrazoğlu, Seda Pınarbaşı, Aylin Gençler, Funda Baştuğ, Neslihan Günay, Kübra Çeleğen, Aytül Noyan, Gönül Parmaksız, Begüm Avcı, Fatma Şemsa Çaycı, Umut Bayrakçı, Sare Gülfem Özlü, Özlem Yüksel Aksoy, Sibel Yel, Güldane Aylin İnal, Seçil Köse, Aysun Karabay Bayazıt, Bahriye Atmış, Emel Sarıbaş, Çağla Çağlı, Yılmaz Tabel, Ahmet Taner Elmas, Şenay Zırhlı Selçuk, Beltinge Demircioğlu Kılıç, Mehtap Akbalık Kara, Mithat Büyükçelik, Ayşe Balat, Betül Durucu Tiryaki, Bilge Erdoğdu, Bağdagül Aksu, Günay Mahmudova, Hasan Dursun, Cengiz Candan, Nilüfer Göknar, Fatma Mutlubaş, Seçil Arslansoyu Çamlar, Cemaliye Başaran, Burcu Bulum Akbulut, Ali Düzova, Bora Gülhan, Çiğdem Oruç, Harun Peru, Harika Alpay, Özde Nisa Türkkan, Rüveyda Gülmez, Mehtap Çelakıl, Kenan Doğan, Ilmay Bilge, Cemile Pehlivanoğlu, Bahar Büyükkaragöz, Emre Leventoğlu, Nuray Alpman, Cengiz Zeybek, Sebahat Tülpar, Rümeysa Yasemin Çiçek Gülşan, Aslıhan Kara, Metin Kaya Gürgöze, Esra Nagehan Önder Akyol, Yeşim Özdemir Atikel, Serim Pul, Ferah Sönmez, Gizem Yıldız, Sema Akman, Midhat Elmacı, Nuran Küçük, Selçuk Yüksel, Aslı Kavaz, Hülya Nalçacıoğlu, Caner Alparslan, Nida Dinçel, Atilla H Elhan, Lale Sever
BACKGROUND/AIMS: Two earthquakes on February 6th, 2023 destroyed ten cities in Türkiye. We report our experience with pediatric victims during these catastrophes, with a focus on crush syndrome related-acute kidney injury (Crush-AKI) and death. METHOD: A web-based software was prepared. Patient demographics, time under rubble (TUR), admission laboratory data, dialysis, and kidney and overall outcomes were asked. RESULTS: 903 injured children (median age: 11...
February 7, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38313210/-gclc-as-a-marker-for-injured-distal-nephron-in-ischemia-reperfusion-induced-acute-kidney-injury
#13
JOURNAL ARTICLE
Yinzheng Li, Shulin Ma, Zheng Wang, Mengxia Shi, Rui Zeng, Ying Yao
PURPOSE: The distal nephron of kidney plays a pivotal role in advancing acute kidney injury (AKI). Understanding the role of distal nephrons in AKI and identifying markers of injured distal nephrons are critical to comprehending the mechanism of renal injury and identifying novel therapeutic targets. METHODS: We analyzed single-cell RNA sequencing (scRNA-seq) data from mice with AKI induced by ischemia-reperfusion (IR), unilateral ureteral obstruction (UUO), cisplatin (CP), sodium oxalate (SO) and lipopolysaccharide (LPS)...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38300832/the-risks-of-first-onset-primary-hypertension-diagnosis-in-thermal-injured-patients
#14
JOURNAL ARTICLE
Tsola A Efejuku, Steven E Wolf, Juquan Song, Georgiy Golovko, Amina El Ayadi
METHODS: Using the TriNetX database, burned patients diagnosed with essential hypertension after injury were compared to those who did not develop hypertension; neither had prior hypertension. Each cohort was grouped by sex, percent total body surface area (TBSA) burned, and age, then propensity-matched for sex, race, ethnicity, and lab values. Outcomes assessed were acute kidney injury (AKI), hyperglycemia, heart failure, myocardial infarction (MI), and death. RESULTS: Those diagnosed with hypertension following severe burn were 4...
January 8, 2024: Shock
https://read.qxmd.com/read/38296190/il-13-alleviates-acute-kidney-injury-and-promotes-regeneration-via-activating-the-jak-stat-signaling-pathway-in-a-rat-kidney-transplantation-model
#15
JOURNAL ARTICLE
Chengjun Yu, Jie Zhang, Jun Pei, Jin Luo, Yifan Hong, Xiaomao Tian, Zhiyuan Liu, Chumeng Zhu, Chunlan Long, Lianju Shen, Xingyue He, Sheng Wen, Xing Liu, Shengde Wu, Yi Hua, Guanghui Wei
AIMS: To identify whether and how a younger systemic internal milieu alleviates acute kidney injury (AKI) in grafts after kidney transplantation. MATERIALS AND METHODS: We conducted an allogenic heterotopic rat kidney transplantation model with young and adult recipients receiving similar donor kidneys. We evaluated the renal function, histological damage, apoptosis, dedifferentiation, proliferation, hub regulating cytokines, and signaling pathways involved in young and adult recipients based on transcriptomics, proteomics, and experimental validation...
January 29, 2024: Life Sciences
https://read.qxmd.com/read/38290569/remimazolam-attenuates-inflammation-and-kidney-fibrosis-following-folic-acid-injury
#16
JOURNAL ARTICLE
Jinfang Song, Wenqiang Yu, Shuangquan Chen, Jiamin Huang, Chujun Zhou, Hua Liang
The transition of acute kidney injury (AKI) to chronic kidney disease (CKD) is characterized by intense inflammation and progressive fibrosis. Remimazolam is widely used for procedural sedation in intensive care units, such as AKI patients. Remimazolam has been shown to possess anti-inflammatory and organ-protective properties. However, the role of remimazolam in inflammation and renal fibrosis following AKI remains unclear. Here, we explored the effects of remimazolam on the inflammatory response and kidney fibrogenesis of mice subjected to folic acid (FA) injury...
January 28, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38256324/muscle-derived-stem-progenitor-cells-ameliorate-acute-kidney-injury-in-rats-through-the-anti-apoptotic-pathway-and-demonstrate-comparable-effects-to-bone-marrow-mesenchymal-stem-cells
#17
JOURNAL ARTICLE
Egle Pavyde, Arvydas Usas, Alius Pockevicius, Romaldas Maciulaitis
Background and Objectives : To date, the therapeutic potential of skeletal muscle-derived stem/progenitor cells (MDSPCs) for acute kidney injury (AKI) has only been evaluated by our research group. We aimed to compare MDSPCs with bone marrow mesenchymal stem cells (BM-MSCs) and evaluate their feasibility for the treatment of AKI. Materials and Methods : Rats were randomly assigned to four study groups: control, GM (gentamicin) group, GM+MDSPCs, and GM+BM-MSCs. AKI was induced by gentamicin (80 mg/kg/day; i...
December 28, 2023: Medicina
https://read.qxmd.com/read/38221742/a-dna-nanostructure-hif-1%C3%AE-inducer-complex-as-novel-nanotherapy-against-cisplatin-induced-acute-kidney-injury
#18
JOURNAL ARTICLE
Yuanchong Chen, Jiangshan Xu, Sirong Shi, Wenjuan Ma, Weitong Cui, Ran Yan, Yunfeng Lin
Since its discovery in 1978, cisplatin-based chemotherapy regimens have served a pivotal role in human cancer treatment, saving millions of lives. However, its high risk still poses a significant challenge for cisplatin-induced acute kidney injury (AKI), which occurs in 30% of cisplatin-treated patients. Unfortunately, no effective solution for preventing or managing this severe complication, which greatly impacts its clinical administration. Kidney is the main organ injured by cisplatin, and the injury is related to cisplatin-induced cell apoptosis and DNA injury...
January 14, 2024: Cell Proliferation
https://read.qxmd.com/read/38204152/predicting-acute-kidney-injury-in-trauma-patients-biomarkers-as-early-indicators
#19
JOURNAL ARTICLE
Michal Frelich, Vojtěch Vodička, Ondřej Jor, Filip Burša, Peter Sklienka
BACKGROUND Acute kidney injury (AKI) is a common cause of organ failure in patients after major trauma and is associated with increased morbidity and mortality. Early identification of patients at risk enables the implementation of a bundle of supportive care, which reduces the incidence of AKI. The primary objective of our study was to investigate whether the levels of biomarkers on admission predicted the onset of early AKI in patients with serious injuries. MATERIAL AND METHODS This prospective observational study included 98 adult patients of both sexes with a serious injury (injury severity score >16)...
January 11, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/38191329/retraction-note-inhibition-of-inflammation-using-diacerein-markedly-improved-renal-function-in-endotoxemic-acute-kidney-injured-mice
#20
Guangzhe Yu, Qian Liu, Xuening Dong, Kaihong Tang, Bohui Li, Chunmei Liu, Wenzheng Zhang, Yiduo Wang, Yingyu Jin
No abstract text is available yet for this article.
January 8, 2024: Cellular & Molecular Biology Letters
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