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JOURNAL ARTICLE
Bochuan Deng, Jiao Zhang, Xiang Zhang, Dan Wang, Lu Cheng, Ping Su, Tingli Yu, Guangjun Bao, Guofeng Li, Liang Hong, Xiaokang Miao, Wenle Yang, Rui Wang, Junqiu Xie
Renal fibrosis is a complex pathological process that contributes to the development of chronic kidney disease due to various risk factors. Conservative treatment to curb progression without dialysis or renal transplantation is widely applicable, but its effectiveness is limited. Here, the inhibitory effect of the novel peptide DR3penA (DHα-(4-pentenyl)-AlaNPQIR-NH2 ), which was developed by our group, on renal fibrosis was assessed in cells and mice with established fibrosis and fibrosis triggered by transforming growth factor-β1 (TGF-β1), unilateral ureteral obstruction, and repeated low-dose cisplatin...
April 12, 2024: ACS Pharmacology & Translational Science
#2
JOURNAL ARTICLE
Xi Zhu, Ershi Hua, Qifeng Tu, Mei Liu, Liqin Xu, Jian Feng
Acute lung injury is a common respiratory disease characterized by diffuse alveolar injury and interstitial edema, as well as a hyperinflammatory response, lung cell damage and oxidative stress. Foxq1, a member of the FOX family of transcription factors, is expressed in various tissues, such as the lungs, liver, and kidneys, and contributes to various biological processes, such as stress, metabolism, cell cycle arrest, and aging-related apoptosis. However, the role of Foxq1 in acute lung injury is unknown. We constructed ex vivo and in vivo acute lung injury models by lipopolysaccharide tracheal perfusion of ICR mice and conditioned medium stimulation of injured MLE-12 cells...
April 4, 2024: American Journal of Respiratory Cell and Molecular Biology
#3
JOURNAL ARTICLE
Chao Yu, Jinhua Tang, Jianjun Yu, Yanjin Wang, Na Liu, Zheng Dong, Shougang Zhuang
We have recently demonstrated that Jumonji domain-containing protein D3 (JMJD3), a histone demethylase of histone H3 on lysine 27 (H3K27me3), is protective against renal fibrosis, but its role in acute kidney injury (AKI) remains unexplored. Here, we report that JMJD3 activity is required for renal protection and regeneration in murine models of AKI induced by ischemia/reperfusion (I/R) and folic acid (FA). Injury to the kidney upregulated JMJD3 expression and induced expression of H3K27me3, which was coincident with renal dysfunction, renal tubular cell injury/apoptosis, and proliferation...
April 15, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
#4
JOURNAL ARTICLE
Jason Bradley Brill, Krislynn M Mueck, Madeline E Cotton, Brian Tang, Mariela Sandoval, Lillian S Kao, Bryan A Cotton
OBJECTIVE: Among critically injured patients of various blood groups, we sought to compare survival and complication rates between COVID-19-positive and COVID-19-negative cohorts. BACKGROUND: SARS-CoV-2 infections have been shown to cause endothelial injury and dysfunctional coagulation. We hypothesized that, among patients with trauma in hemorrhagic shock, COVID-19-positive status would be associated with increased mortality and inpatient complications. As a secondary hypothesis, we suspected group O patients with COVID-19 would experience fewer complications than non-group O patients with COVID-19...
2024: Trauma Surgery & Acute Care Open
#5
JOURNAL ARTICLE
Ru Sun, Qun Gu, Xufeng Zhang, Ruiqi Zeng, Dan Chen, Jingjing Yao, Jingjing Min
UNLABELLED: Chronic renal failure (CRF) resulting in vascular calcification, which does damage to blood vessels and endothelium, is an independent risk factor for stroke. It has been reported that cilostazol has a protective effect on the focal cerebral ischemic infarct. However, its impact on vascular injury in CRF combined stroke and its molecular protection mechanism have not been investigated. In this study, we carried out the effect of cilostazol on CRF combined stroke rats, and the results confirmed that it improved the neurobehavior, renal function as well as pathologic changes in both the kidney and brain...
April 2024: Toxicological Research
#6
JOURNAL ARTICLE
Heidi A Creed, Saranya Kannan, Brittany L Tate, David Godefroy, Priyanka Banerjee, Brett M Mitchell, Ebba Brakenhielm, Sanjukta Chakraborty, Joseph M Rutkowski
SIGNIFICANCE STATEMENT: The renal lymphatic vasculature and the lymphatic endothelial cells that make up this network play important immunomodulatory roles during inflammation. How lymphatics respond to AKI may affect AKI outcomes. The authors used single-cell RNA sequencing to characterize mouse renal lymphatic endothelial cells in quiescent and cisplatin-injured kidneys. lymphatic endothelial cell gene expression changes were confirmed in ischemia-reperfusion injury and in cultured lymphatic endothelial cells, validating renal lymphatic endothelial cells single-cell RNA sequencing data...
February 7, 2024: Journal of the American Society of Nephrology: JASN
#7
JOURNAL ARTICLE
Shayna T J Bradford, Haojia Wu, Yuhei Kirita, Changfeng Chen, Nicole P Malvin, Yasuhiro Yoshimura, Yoshiharu Muto, Benjamin D Humphreys
In the aftermath of acute kidney injury (AKI), surviving proximal tubule epithelia repopulate injured tubules to promote repair. However, a portion of cells fail to repair (termed Failed Repair Proximal Tubule Cells, FR-PTCs) and exert ongoing proinflammatory and profibrotic effects. To better understand the molecular drivers of the FR-PTC state, we reanalyzed a mouse ischemia-reperfusion injury single nucleus RNA-sequencing (snRNA-seq) atlas to identify Traf2 and Nck Interacting Kinase, Tnik, to be exclusively expressed in FR-PTCs, but not in healthy or acutely injured proximal tubules post AKI (2 and 6 weeks) in mice...
March 14, 2024: American Journal of Physiology. Renal Physiology
#8
JOURNAL ARTICLE
Minhai Zhang, Jingyuan Yang, Guodong Liang, Huiqiong Yuan, Yanni Wu, Li Li, Tao Yu, Yuling Zhang, Jingfeng Wang
OBJECTIVE: This study aimed to investigate the role of FOXA1 in acute kidney injury (AKI) induced by radiotherapy in colorectal cancer. Although FOXA1 is known to be aberrantly expressed in malignant tumors, its contribution to AKI remains unclear. This study aimed to explore the involvement of FOXA1 in AKI induced by radiotherapy in colorectal cancer and its influence on the regulation of downstream target genes. METHODS: Firstly, a transcriptome analysis was performed on mice to establish a radiation-induced AKI model, and qPCR was used to determine the expression of FOXA1 in renal cell injury models induced by X-ray irradiation...
March 11, 2024: International Immunopharmacology
#9
Yohei Komaru, Liang Ning, Carine Lama, Anusha Suresh, Eirini Kefaloyianni, Mark J Miller, Andreas Herrlich
Sterile tissue injury, such as by acute kidney injury, is common in the clinic and frequently associated with respiratory compromise and hypoxemia. We previously described signaling components released by the injured kidney that drive a remote inflammatory response in the lung. How this caused the resultant hypoxemia remained unclear. Here, we report that sterile kidney tissue injury induces rapid intravascular "neutrophil train" formation in lung capillaries, a novel form of neutrophil swarming. Rapid swarming is enhanced by decreased deformability of circulating neutrophils that impedes their lung capillary passage...
March 2, 2024: bioRxiv
#10
JOURNAL ARTICLE
Jay L Koyner, Rachel H Mackey, Jorge Echeverri, Ning A Rosenthal, Leslie A Carabuena, Daniel Bronson-Lowe, Kai Harenski, Javier A Neyra
PURPOSE: Real-world comparison of RRT modality on RRT dependence at 90 days postdischarge among ICU patients discharged alive after RRT for acute kidney injury (AKI). METHODS: Using claims-linked to US hospital discharge data (Premier PINC AI Healthcare Database [PHD]), we compared continuous renal replacement therapy (CRRT) vs. intermittent hemodialysis (IHD) for AKI in adult ICU patients discharged alive from January 1, 2018 to June 30, 2021. RRT dependence at 90 days postdischarge was defined as ≥2 RRT treatments in the last 8 days...
March 8, 2024: Journal of Critical Care
#11
JOURNAL ARTICLE
Lineage tracing reveals transient phenotypic adaptation of tubular cells during acute kidney injury.
Marc Buse, Mingbo Cheng, Vera Jankowski, Michaela Lellig, Viktor Sterzer, Thiago Strieder, Katja Leuchtle, Ina V Martin, Claudia Seikrit, Paul Brinkkoettter, Giuliano Crispatzu, Jürgen Floege, Peter Boor, Timotheus Speer, Rafael Kramann, Tammo Ostendorf, Marcus J Moeller, Ivan G Costa, Eleni Stamellou
Tubular injury is the hallmark of acute kidney injury (AKI) with a tremendous impact on patients and health-care systems. During injury, any differentiated proximal tubular cell (PT) may transition into a specific injured phenotype, so-called "scattered tubular cell" (STC)-phenotype. To understand the fate of this specific phenotype, we generated transgenic mice allowing inducible, reversible, and irreversible tagging of these cells in a murine AKI model, the unilateral ischemia-reperfusion injury (IRI). For lineage tracing, we analyzed the kidneys using single-cell profiling during disease development at various time points...
March 15, 2024: IScience
#12
JOURNAL ARTICLE
Evans O Asowata, Simone Romoli, Rebecca Sargeant, Jennifer Y Tan, Scott Hoffmann, Margaret M Huang, Krishnaa T Mahbubani, Fynn N Krause, Daniel Jachimowicz, Rasmus Agren, Albert Koulman, Benjamin Jenkins, Barbara Musial, Julian L Griffin, Magnus Soderberg, Stephanie Ling, Pernille B L Hansen, Kourosh Saeb-Parsy, Kevin J Woollard
Despite the recent advances in our understanding of the role of lipids, metabolites and related enzymes in mediating kidney injury, there is limited integrated multi-omics data identifying potential metabolic pathways driving impaired kidney function. The limited availability of kidney biopsies from living donors with acute kidney injury has remained a major constraint. Here, we validated the use of deceased transplant donor kidneys as a good model to study acute kidney injury in humans and characterized these kidneys using imaging and multi-omics approaches...
February 29, 2024: Kidney International
#13
Renal vein thrombosis in the course of non-operative treatment of kidney trauma: A rare case report.
João Henrique Fonseca Nascimento, André Bouzas de Andrade, Márcio Rivison Silva Cruz, Roberto Valente Filho, André Gusmão-Cunha, Gabriel Schnitman
INTRODUCTION: Venous thromboembolism is widely recognized as a life-threatening complication in trauma, yet renal vein thrombosis (RVT) following trauma is particularly rare. PRESENTATION OF CASE: We report a case of a 67-year-old man who was brought to the emergency department after falling down a 14-step staircase at home which presented right kidney trauma (parenchyma laceration with a perirenal hematoma) on computed tomography, and hematuria. Considering the patient's hemodynamic stability, a non-operative treatment was initiated, and the patient was referred to the intensive care unit for close observation...
February 22, 2024: International Journal of Surgery Case Reports
#14
JOURNAL ARTICLE
Shikhar Aggarwal, Zhanxiang Wang, David Rincon Fernandez Pacheco, Anna Rinaldi, Alex Rajewski, Jasper Callemeyn, Elisabet Van Loon, Baptiste Lamarthée, Ambart Ester Covarrubias, Jean Hou, Michifumi Yamashita, Haruhiko Akiyama, S Ananth Karumanchi, Clive N Svendsen, Paul W Noble, Stanley C Jordan, Joshua J Breunig, Maarten Naesens, Pietro E Cippà, Sanjeev Kumar
The steps governing healing with or without fibrosis within the same microenvironment are unclear. After acute kidney injury (AKI), injured proximal tubular epithelial cells activate SOX9 for self-restoration. Using a multimodal approach for a head-to-head comparison of injury-induced SOX9 lineages, we identified a dynamic SOX9 switch in repairing epithelia. Lineages that regenerated epithelia silenced SOX9 and healed without fibrosis (SOX9on-off ). By contrast, lineages with unrestored apicobasal polarity maintained SOX9 activity in sustained efforts to regenerate, which were identified as a SOX9on-on Cadherin6pos cell state...
February 23, 2024: Science
#15
JOURNAL ARTICLE
Jeferson Stabile, Raquel Silva Neres-Santos, Isabela Dorta Molina Hernandes, Carolina Victória Cruz Junho, Geovane Felippe Alves, Isabella Cardoso Silva, Marcela Sorelli Carneiro-Ramos, Cristina Ribas Fürstenau
AIMS: Acute kidney injury (AKI) is a public health problem and represents a risk factor for cardiovascular diseases (CVD) and vascular damage. This study aimed to investigate the impact of AKI on purinergic components in mice aorta. MAIN METHODS: The kidney ischemia was achieved by the occlusion of the left kidney pedicle for 60 min, followed by reperfusion for 8 (IR8) and 15 (IR15) days. Renal function was assessed through biochemical assays, while gene expression levels were evaluated by RT-qPCR...
February 13, 2024: Biochimie
#16
JOURNAL ARTICLE
Elena Tutunea-Fatan, Shabitha Arumugarajah, Rita S Suri, Cassandra R Edgar, Ingrid Hon, Jimmy D Dikeakos, Lakshman Gunaratnam
Kidney Injury Molecule-1 (KIM-1), also known as T cell immunoglobulin and mucin domain-1 (TIM-1), is a widely recognized biomarker for acute kidney injury, but its biological function is less appreciated. KIM-1/TIM-1 belongs to the TIM family of conserved transmembrane proteins which bear the characteristic six-cysteine immunoglobulin-like (IgV) domain. The latter enables binding of KIM-1/TIM-1 to its natural ligand, phosphatidylserine, expressed on the surface of apoptotic cells and necrotic cells. KIM-1/TIM-1 is expressed in a variety of tissues and plays fundamental roles in regulating sterile inflammation and adaptive immune responses...
February 14, 2024: Journal of the American Society of Nephrology: JASN
#17
JOURNAL ARTICLE
Liyao Xu, Zhaoyu Xing, Jiaxin Yuan, Yaobao Han, Zhilin Jiang, Mengxiao Han, Xianao Hou, Wei Xing, Zhen Li
Renal ischemia-reperfusion injury (IRI) is a common disease with high morbidity and mortality. Renal IRI can cause the disorder of immune microenvironment and reprograming the immune microenvironment to alleviate excessive inflammatory response is crucial for its treatment. Cytokine IL-33 can improve the immune inflammatory microenvironment by modulating both innate and adaptive immune cells, and serve as an important target for modulating immune microenvironment of renal IRI. Herein, we report that bilobetin-functionalized ultra-small Cu2-x Se nanoparticles (i...
February 9, 2024: Advanced Healthcare Materials
#18
JOURNAL ARTICLE
Sevcan A Bakkaloğlu, Ali Delibaş, Serra Sürmeli Döven, Sevgin Taner, Sevgi Yavuz, Gökçen Erfidan, Esra Danacı Vatansever, Fatma Aynacı, Kenan Yilmaz, Mehmet Taşdemir, Okan Akacı, Nurver Akıncı, Serçin Güven, Neslihan Çiçek, Ismail Dursun, Emre Keleşoğlu, Muhammet Sancaktar, Demet Alaygut, Seha Saygılı, Önder Yavaşcan, Alev Yılmaz, Kaan Gülleroğlu, Pelin Ertan, Belde Kasap Demir, Hakan Poyrazoğlu, Seda Pınarbaşı, Aylin Gençler, Funda Baştuğ, Neslihan Günay, Kübra Çeleğen, Aytül Noyan, Gönül Parmaksız, Begüm Avcı, Fatma Şemsa Çaycı, Umut Bayrakçı, Sare Gülfem Özlü, Özlem Yüksel Aksoy, Sibel Yel, Güldane Aylin İnal, Seçil Köse, Aysun Karabay Bayazıt, Bahriye Atmış, Emel Sarıbaş, Çağla Çağlı, Yılmaz Tabel, Ahmet Taner Elmas, Şenay Zırhlı Selçuk, Beltinge Demircioğlu Kılıç, Mehtap Akbalık Kara, Mithat Büyükçelik, Ayşe Balat, Betül Durucu Tiryaki, Bilge Erdoğdu, Bağdagül Aksu, Günay Mahmudova, Hasan Dursun, Cengiz Candan, Nilüfer Göknar, Fatma Mutlubaş, Seçil Arslansoyu Çamlar, Cemaliye Başaran, Burcu Bulum Akbulut, Ali Düzova, Bora Gülhan, Çiğdem Oruç, Harun Peru, Harika Alpay, Özde Nisa Türkkan, Rüveyda Gülmez, Mehtap Çelakıl, Kenan Doğan, Ilmay Bilge, Cemile Pehlivanoğlu, Bahar Büyükkaragöz, Emre Leventoğlu, Nuray Alpman, Cengiz Zeybek, Sebahat Tülpar, Rümeysa Yasemin Çiçek Gülşan, Aslıhan Kara, Metin Kaya Gürgöze, Esra Nagehan Önder Akyol, Yeşim Özdemir Atikel, Serim Pul, Ferah Sönmez, Gizem Yıldız, Sema Akman, Midhat Elmacı, Nuran Küçük, Selçuk Yüksel, Aslı Kavaz, Hülya Nalçacıoğlu, Caner Alparslan, Nida Dinçel, Atilla H Elhan, Lale Sever
BACKGROUND/AIMS: Two earthquakes on February 6th, 2023 destroyed ten cities in Türkiye. We report our experience with pediatric victims during these catastrophes, with a focus on crush syndrome related-acute kidney injury (Crush-AKI) and death. METHOD: A web-based software was prepared. Patient demographics, time under rubble (TUR), admission laboratory data, dialysis, and kidney and overall outcomes were asked. RESULTS: 903 injured children (median age: 11...
February 7, 2024: Nephrology, Dialysis, Transplantation
#19
JOURNAL ARTICLE
Yinzheng Li, Shulin Ma, Zheng Wang, Mengxia Shi, Rui Zeng, Ying Yao
PURPOSE: The distal nephron of kidney plays a pivotal role in advancing acute kidney injury (AKI). Understanding the role of distal nephrons in AKI and identifying markers of injured distal nephrons are critical to comprehending the mechanism of renal injury and identifying novel therapeutic targets. METHODS: We analyzed single-cell RNA sequencing (scRNA-seq) data from mice with AKI induced by ischemia-reperfusion (IR), unilateral ureteral obstruction (UUO), cisplatin (CP), sodium oxalate (SO) and lipopolysaccharide (LPS)...
2024: Journal of Inflammation Research
#20
JOURNAL ARTICLE
Tsola A Efejuku, Steven E Wolf, Juquan Song, Georgiy Golovko, Amina El Ayadi
METHODS: Using the TriNetX database, burned patients diagnosed with essential hypertension after injury were compared to those who did not develop hypertension; neither had prior hypertension. Each cohort was grouped by sex, percent total body surface area (TBSA) burned, and age, then propensity-matched for sex, race, ethnicity, and lab values. Outcomes assessed were acute kidney injury (AKI), hyperglycemia, heart failure, myocardial infarction (MI), and death. RESULTS: Those diagnosed with hypertension following severe burn were 4...
January 8, 2024: Shock
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