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acute kidney injure

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https://www.readbyqxmd.com/read/28333137/the-mtor-signal-regulates-myeloid-derived-suppressor-cells-differentiation-and-immunosuppressive-function-in-acute-kidney-injury
#1
Chao Zhang, Shuo Wang, Jiawei Li, Weitao Zhang, Long Zheng, Cheng Yang, Tongyu Zhu, Ruiming Rong
The mammalian target of rapamycin (mTOR) signal controls innate and adaptive immune response in multiple immunoregulatory contexts. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of myeloid cells of potent immunosuppressive capacity. In this study, we aimed to investigate the role of MDSCs in the protection of acute kidney injury (AKI) and the regulation of mTOR signal on MDSC's protective role in this context. In mice AKI model, rapamycin administration was associated with improved renal function, restored histological damage and decreased CD4(+) and CD8(+) T-cell infiltration in kidney tissue...
March 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28323627/effects-of-xuebijing-injection-for-patients-with-sepsis-induced-acute-kidney-injury-after-wenchuan-earthquake
#2
Qin Yuxi, Hanlai Zhang, Yu Baili, Shihua Shi
Context • Earthquakes are devastating disasters that have claimed countless lives in the past, partially owing to the danger of direct and indirect injuries to vital organs. In the deadly earthquake that occurred in Sichuan Province of China on May 12, 2008, some victims suffered from severe damage to multiple organs and tissue and developed sepsis, a systematic inflammatory reaction resulting from infection and trauma. Xuebijing injection (CCXG) could beneficial for improvement of clinical symptoms in those patients, but no research has yet examined its potential...
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28284382/medication-induced-interstitial-nephritis-in-the-21st-century
#3
REVIEW
Cynthia C Nast
Interstitial nephritis is an immune mediated form of tubulointerstitial kidney injury that may occur secondary to drugs, autoimmune disease, infections, and hematologic disorders or as a reactive process. Drug-induced acute interstitial nephritis (DI-AIN) occurs in 0.5%-3% of all kidney biopsies and in 5%-27% of biopsies performed for acute kidney injury. Drugs are implicated in 70%-90% of biopsy-proved IN with a prevalence of 50% in less developed to 78% in more developed countries. DI-AIN typically is idiosyncratic because of a delayed hypersensitivity reaction, although some chemotherapeutic agents are permissive for immune upregulation and injure the kidney in a dose-related manner...
March 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/28276451/comparison-of-human-adipose-stromal-vascular-fraction-and-adipose-derived-mesenchymal-stem-cells-for-the-attenuation-of-acute-renal-ischemia-reperfusion-injury
#4
Liuhua Zhou, Qun Song, Jiangwei Shen, Luwei Xu, Zheng Xu, Ran Wu, Yuzheng Ge, Jiageng Zhu, Jianping Wu, Quanliang Dou, Ruipeng Jia
Stem cells therapy has been suggested as a promising option for the treatment of acute kidney injury (AKI). This study was performed to compare the abilities of xenogenic transplantation of human adipose stromal vascular fraction (SVF) and adipose-derived mesenchymal stem cells (AdMSCs) to facilitate the recovery of renal function and structure in a rat model of ischemia/reperfusion (IR) induced AKI. SVF or AdMSCs were transplanted to the injured kidney through intra-parenchymal injection. Significantly improved renal function and reduced tubular injury were observed in SVF and AdMSCs groups...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28275112/clic1-null-mice-demonstrate-a-role-for-clic1-in-macrophage-superoxide-production-and-tissue-injury
#5
Barbara Ulmasov, Jonathan Bruno, Kiyoko Oshima, Yao-Wen Cheng, Stephen P Holly, Leslie V Parise, Terrance M Egan, John C Edwards
We generated and studied CLIC1 null (C1KO) mice to investigate the physiological role of this protein. C1KO and matched wild-type (WT) mice were studied in two models of acute toxic tissue injury. CLIC1 expression is upregulated following acute injury of WT kidney and pancreas and is absent in C1KOs. Acute tissue injury is attenuated in the C1KOs and this correlates with an absence of the rise in tissue reactive oxygen species (ROS) that is seen in WT mice. Infiltration of injured tissue by inflammatory cells was comparable between WT and C1KOs...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28129098/expression-of-kidney-injury-molecule-1-in-healthy-and-diseased-feline-kidney-tissue
#6
S K Bland, C W Schmiedt, M E Clark, J DeLay, D Bienzle
Sensitive markers to detect acute kidney injury (AKI) in cats are lacking. Kidney injury molecule-1 (KIM-1) is a promising marker of acute tubular injury in humans, and sequence and structure of feline KIM-1 have been determined. KIM-1 is shed into urine of cats with natural AKI. The objectives of this study were to characterize temporal and cellular expression of KIM-1 in kidneys from cats without and with experimental and natural AKI using histopathology and immunohistochemistry. Tissue sections from 8 cats without kidney disease, 3 to 4 cats with experimentally induced AKI on each day 1, 3, 6, and 12 after unilateral ischemia/reperfusion, and 9 cats with natural AKI were assessed...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28117405/biological-membrane-packed-mesenchymal-stem-cells-treat-acute-kidney-disease-by-ameliorating-mitochondrial-related-apoptosis
#7
Xiaodong Geng, Quan Hong, Weiwei Wang, Wei Zheng, Ou Li, Guangyan Cai, Xiangmei Chen, Di Wu
The mortality of rhabdomyolysis-induced AKI remains high because no effective therapy exists. We investigated a new therapeutic method using MSCs. The aim of this study was to investigate the therapeutic potential and anti-apoptotic mechanisms of action of MSCs in the treatment of AKI induced by glycerol in vivo and in vitro. We used Duragen as a biological membrane to pack MSCs on the glycerol-injured renal tissue in vivo. The anti-apoptotic mechanism was investigated. In vitro, HK-2 cells were incubated with ferrous myoglobin and MSCs-conditioned medium, followed by cell proliferation and apoptosis assays...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28052874/inhibition-of-hdac6-protects-against-rhabdomyolysis-induced-acute-kidney-injury
#8
Yingfeng Shi, Liuqing Xu, Jinhua Tang, Lu Fang, Shuchen Ma, Xiaoyan Ma, Jing Nie, Xiaoling Pi, Andong Qiu, Shougang Zhuang, Na Liu
Histone deacetylase 6 (HDAC6) inhibition has been reported to protect against ischemic stroke and prolong survival after sepsis in animal models. However, it remains unknown whether HDAC6 inhibition offers a renoprotective effect after acute kidney injury (AKI). In this study, we examined the therapeutic effect of tubastatin A (TA), a highly selective inhibitor of HDAC6, on AKI in a murine model of glycerol (GL) injection-induced rhabdomyolysis. Following GL injection, the mice developed severe acute tubular injury as indicated by renal dysfunction, expression of neutrophil gelatinase-associated lipocalin (NGAL), an injury marker of renal tubules and increase of TUNEL positive tubular cells...
January 4, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27990569/icariin-treated-human-umbilical-cord-mesenchymal-stem-cells-decrease-chronic-liver-injury-in-mice
#9
Huantian Cui, Zhen Liu, Li Wang, Yuhong Bian, Wen Li, Huifang Zhou, Xiaoqian Chu, Qingyun Zhao
Human umbilical cord mesenchymal stem cells (hUMSCs) have been shown to have multiple differentiation potentials. However, a key problem is that only a small number of hUMSCs can migrate to damaged tissue after transplantation. According to "The Theory of Kidney Essence" in Traditional Chinese Medicine, some traditional Chinese medicines used for tonifying the kidneys can be applied in promoting the differentiation and migration of stem cells in vivo. Our previous study demonstrated that icariin (ICA) could up-regulate the pluripotent genes of hUMSCs in vitro and induce cell migration in mice in an acute kidney injury model in vivo...
February 2017: Cytotechnology
https://www.readbyqxmd.com/read/27975097/an-injectable-collagen-poly-%C3%AE-glutamic-acid-hydrogel-as-a-scaffold-of-stem-cells-and-%C3%AE-lipoic-acid-for-enhanced-protection-against-renal-dysfunction
#10
Sun-Hee Cho, Jung-Ran Noh, Mi Young Cho, Min-Jeong Go, Yong-Hoon Kim, Eun Sung Kang, Yong Ho Kim, Chul-Ho Lee, Yong Taik Lim
Mesenchymal stem cells (MSCs) can ameliorate renal injury and accelerate repair of acute kidney injury. Herein, we developed a collagen/poly(γ-glutamic acid) (γ-PGA) hydrogel as an injectable scaffold for the delivery of mouse MSCs (mMSCs) and anti-oxidant drugs into injured sites. By the introduction of γ-PGA into conventional collagen, the viscosity of collagen was reduced at ambient temperature for easy handling, while the elastic and viscous moduli of collagen were increased and a new porous structure was generated near body temperature...
December 15, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27929116/a-proteolytic-modification-of-aim-promotes-its-renal-excretion
#11
Tomoko Yamazaki, Ryoichi Sugisawa, Emiri Hiramoto, Ryosuke Takai, Ayaka Matsumoto, Yoshie Senda, Katsuhiko Nakashima, Peter S Nelson, Jared M Lucas, Andrew Morgan, Zhenghua Li, Ken-Ichi Yamamura, Satoko Arai, Toru Miyazaki
Apoptosis inhibitor of macrophage (AIM, encoded by cd5l) is a multi-functional circulating protein that has a beneficial role in the regulation of a broad range of diseases, some of which are ameliorated by AIM administration in mice. In blood, AIM is stabilized by association with IgM pentamers and maintains its high circulating levels. The mechanism regulating the excessive accumulation of blood AIM remains unknown, although it is important, since a constitutive increase in AIM levels promotes chronic inflammation...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27927651/dna-repair-in-ischemic-acute-kidney-injury
#12
Jeffrey David Pressly, Frank Park
Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) leading to an induction of oxidative stress, cellular dysfunction and a loss of renal function. DNA damage, including oxidative base modifications and physical DNA strand breaks, is a consequence of renal IRI. Like many other organs in the body, a redundant and highly conserved set of endogenous repair pathways have evolved to selectively recognize the various types of cellular DNA damage and combat its negative effects on cell viability...
December 7, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27884305/micrornas-in-extracellular-vesicles-protect-kidney-from%C3%A2-ischemic-injury-from-endothelial-to-tubular-epithelial
#13
Man Jiang Livingston, Qingqing Wei
Extracellular vesicles from stem cells or progenitor cells are novel therapeutic systems for acute kidney injury. With exosomes (the smallest class of extracellular vesicles), Viñas et al. successfully rescued ischemic injured kidney. MicroRNA-486-5p, the crucial factor specifically delivered by exosomes to kidney, ameliorates the injury by targeting phosphatase and tensin homolog and inhibiting endothelial cell apoptosis. In this commentary, we discuss the potential underlying mechanism and the pivotal impact of their study on extracellular vesicle therapy...
December 2016: Kidney International
https://www.readbyqxmd.com/read/27876077/post-traumatic-acute-kidney-injury-a-cross-sectional-study-of-trauma-patients
#14
Wei-Hung Lai, Cheng-Shyuan Rau, Shao-Chun Wu, Yi-Chun Chen, Pao-Jen Kuo, Shiun-Yuan Hsu, Ching-Hua Hsieh, Hsiao-Yun Hsieh
BACKGROUND: The causes of post-traumatic acute kidney injury (AKI) are multifactorial, and shock associated with major trauma has been proposed to result in inadequate renal perfusion and subsequent AKI in trauma patients. This study aimed to investigate the true incidence and clinical presentation of post-traumatic AKI in hospitalized adult patients and its association with shock at a Level I trauma center. METHODS: Detailed data of 78 trauma patients with AKI and 14,504 patients without AKI between January 1, 2009 and December 31, 2014 were retrieved from the Trauma Registry System...
November 22, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27871857/bmi-1-plays-a-critical-role-in-the-protection-from-acute-tubular-necrosis-by-mobilizing-renal-stem-progenitor-cells
#15
Xianhui Lv, Zhenzhen Yu, Chunfeng Xie, Xiuliang Dai, Qing Li, Dengshun Miao, Jianliang Jin
The regeneration of injured tubular cell occurs primarily from intrinsic renal stem/progenitor cells (RSCs) labeled with CD24 and CD133 after acute tubular necrosis (ATN). Bmi-1 plays a crucial role in regulating self-renewal, differentiation and aging of multiple adult stem cells and progenitor cells. Bmi-1 was rapidly elevated in the induction of adult kidney regeneration by renal injury. To determine whether Bmi-1 maintained mobilization of RSCs in the protection from ATN, glycerol-rhabdomyolysis-induced ATN were performed in wild type (WT) and Bmi-1-deficient (Bmi-1(-/-)) mice...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27822039/carbon-monoxide-bound-hemoglobin-vesicles-ameliorate-multiorgan-injuries-induced-by-severe-acute-pancreatitis-in-mice-by-their-anti-inflammatory-and-antioxidant-properties
#16
Saori Nagao, Kazuaki Taguchi, Hiromi Sakai, Keishi Yamasaki, Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama
Carbon monoxide (CO) has attracted attention as a possible therapeutic agent for affecting anti-inflammatory and antioxidant activities. Previously, CO-bound hemoglobin vesicle (CO-HbV) was developed as a nanotechnology-based CO donor, and its safety profile and therapeutic potential as a clinically applicable carrier of CO were examined in vitro and in vivo. In the present study, the therapeutic efficacy of CO-HbV against severe acute pancreatitis was examined with secondary distal organ-injured model mice that were fed with a choline-deficient ethionine-supplemented diet...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27820705/use-of-stress-tests-in-evaluating-kidney-disease
#17
Jay L Koyner, Lakhmir S Chawla
PURPOSE OF REVIEW: The kidney, like most other organs, has a reserve capacity that can be utilized in times of increased physiologic demand. The ability to quantify this renal reserve function across various parts of the nephron (glomerular and tubular) has been an area of increased investigation over the past several years. In this review, we discuss several techniques that have been developed to interrogate the maximal physiologic capacity of the injured kidney. RECENT FINDINGS: Although protein loading has been established as an ideal method to investigate glomerular filtration capacity in healthy kidneys, other methods such as the antagonism of the renin-angiotensin-aldosterone system have demonstrated promise as a method to determine underlying glomerular disease in those with acute kidney injury and other comorbidities (e...
January 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/27799943/mesenchymal-stromal-cells-derived-extracellular-vesicles-ameliorate-acute-renal-ischemia-reperfusion-injury-by-inhibition-of-mitochondrial-fission-through-mir-30
#18
Di Gu, Xiangyu Zou, Guanqun Ju, Guangyuan Zhang, Erdun Bao, Yingjian Zhu
Background. The immoderation of mitochondrial fission is one of the main contributors in ischemia reperfusion injury (IRI) and mesenchymal stromal cells (MSCs) derived extracellular vesicles have been regarded as a potential therapy method. Here, we hypothesized that extracellular vesicles (EVs) derived from human Wharton Jelly mesenchymal stromal cells (hWJMSCs) ameliorate acute renal IRI by inhibiting mitochondrial fission through miR-30b/c/d. Methods. EVs isolated from the condition medium of MCS were injected intravenously in rats immediately after monolateral nephrectomy and renal pedicle occlusion for 45 minutes...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27760220/testing-danegaptide-effects-on-kidney-function-after-ischemia-reperfusion-injury-in-a-new-porcine-two-week-model
#19
Chris Amdisen, Anna K Keller, Rie Schultz Hansen, Rikke Nørregaard, Søren Palmelund Krag, Ulla Møldrup, Michael Pedersen, Bente Jespersen, Henrik Birn
INTRODUCTION: Ischemia/reperfusion injury (I/R-I) is a leading cause of acute kidney injury (AKI) and is associated with increased mortality. Danegaptide is a selective modifier of the gap junction protein connexion 43. It has cytoprotective as well as anti-arrhythmic properties and has been shown to reduce the size of myocardial infarct in pigs. The aim of this study was to investigate the ischemia-protective effect of Danegaptide in a porcine renal I/R-I model with two weeks follow up...
2016: PloS One
https://www.readbyqxmd.com/read/27734073/idarucizumab-administration-for-reversing-dabigatran-effect-in-an-acute-kidney-injured-patient-with-bleeding
#20
Hervé Quintard, Delphine Viard, Milou-Daniel Drici, Caroline Ruetsch, Charles Marc Samama, Carole Ichai
No abstract text is available yet for this article.
October 13, 2016: Thrombosis and Haemostasis
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