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https://www.readbyqxmd.com/read/28722597/occult-amoebic-liver-abscess-as-cause-of-extensive-inferior-vena-cava-and-hepatic-vein-thrombosis
#1
Leslie Martin, Nishigandha Burute, Ehsan Haider, Pablo E Serrano, Timothy O'Shea, Deborah Siegal
The most common extraintestinal complication of Entamoeba histolytica is amoebic liver abscess (ALA). Hepatic vein and inferior vena cava (IVC) thrombosis are rare but well-documented complications of ALA, typically attributed to mechanical compression and inflammation associated with a large abscess. We present a case of a previously healthy 43-year-old Canadian man presenting with constitutional symptoms and right upper quadrant abdominal pain. He was found to have thrombophlebitis of the IVC, accessory right hepatic vein, and bilateral iliac veins...
July 3, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28716645/update-in-management-of-severe-hypoxemic-respiratory-failure
#2
REVIEW
Dharani Kumari Narendra, Dean R Hess, Curtis N Sessler, Habtamu M Belete, Kalpalatha K Guntupalli, Felix Khusid, Charles Mark Carpati, Mark Elton Astiz, Suhail Raoof
Mortality related to severe-moderate and severe ARDS remains high. We searched the literature to update this topic. We defined severe hypoxemic respiratory failure as PaO2/FIO2 < 150 mm Hg (i.e., severe-moderate and severe ARDS). For these patients, we support setting the ventilator to a tidal volume of 4-8 mL/kg predicted body weight (PBW) with plateau pressure ≤30 cm H2O, and initial PEEP of 10 - 12 cm H2O. To promote alveolar recruitment, we propose increasing PEEP in increments of 2 - 3 cm, provided plateau pressure remains ≤30 cm H2O and driving pressure does not increase...
July 14, 2017: Chest
https://www.readbyqxmd.com/read/28713758/two-concurrent-large-epidermoid-cysts-in-sublingual-and-submental-region-resembling-plunging-ranula-report-of-a-rare-case
#3
Ranjan Kumar Sahoo, Pradyumna Kumar Sahoo, Debahuti Mohapatra, Santosh Subudhi
An elderly female patient presented to surgical outpatient clinic with complaint of gradual onset of painless submental and sublingual midline swellings for 6 months of duration. The swellings were noncompressible, nontranslucent, nonpulsatile, and nontender on palpation. Clinical diagnosis was plunging ranula or dermoid cysts. Ultrasound examination of sublingual swelling showed cystic lesion with particulate content. Submental swelling showed cystic swelling with few echogenic floating lobules inside suggesting possibility of epidermoid/dermoid cyst...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28708576/adiponectin-concentration-in-mid-trimester-amniotic-fluid-varies-with-the-%C3%AE-amylase-level-and-maternal-and-neonatal-outcomes
#4
Joseph Chervenak, Mio Sawai, Lamis El Kabab, Rahul Lohana, Daniel Skupski, Steven S Witkin
OBJECTIVE: Factors influencing intraamniotic adiponectin levels and their functional significance remain incompletely elucidated. We prospectively measured adiponectin in amniotic fluid and identified its associations with maternal parameters, mediators in amniotic fluid and pregnancy outcomes. STUDY DESIGN: Mid-trimester amniotic fluid from 571 women was tested for adiponectin, interleukin (IL)-6, IL-8 and α-amylase by enzyme-linked immunosorbant assay (ELISA), after which clinical data were obtained...
July 14, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28706287/association-of-wall-shear-stress-with-intracranial-aneurysm-rupture-systematic-review-and-meta-analysis
#5
Geng Zhou, Yueqi Zhu, Yanling Yin, Ming Su, Minghua Li
To evaluate the relationship between wall shear stress (WSS) magnitude and cerebral aneurysm rupture and provide new insight into the disparate computational fluid dynamics (CFD) findings concerning the role of WSS in intracranial aneurysm (IA) rupture. A systematic electronic database (PubMed, Medline, Springer, and EBSCO) search was conducted for all accessible published articles up to July 1, 2016, with no restriction on the publication year. Abstracts, full-text manuscripts, and the reference lists of retrieved articles were analyzed...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28701191/blood-brain-barrier-and-foetal-onset-hydrocephalus-with-a-view-on-potential-novel-treatments-beyond-managing-csf-flow
#6
REVIEW
M Guerra, J L Blázquez, E M Rodríguez
Despite decades of research, no compelling non-surgical therapies have been developed for foetal hydrocephalus. So far, most efforts have pointed to repairing disturbances in the cerebrospinal fluid (CSF) flow and to avoid further brain damage. There are no reports trying to prevent or diminish abnormalities in brain development which are inseparably associated with hydrocephalus. A key problem in the treatment of hydrocephalus is the blood-brain barrier that restricts the access to the brain for therapeutic compounds or systemically grafted cells...
July 13, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28701011/action-plan-for-prolongation-of-nephrogenesis-in-preterm-and-growth-restricted-babies-explore-ultrastructure-of-the-nephrogenic-zone-identify-a-molecular-target-select-a-viable-drug-and-find-a-path-for-administration
#7
Will W Minuth
A large amount of investigations informs about primary steps of mammalian kidney development such as anlage of the organ and initial nephron formation, while only few data exists about the late phase of human kidney development. In particular, little attention was up to date addressed to the decrease of morphogenic activity in the nephrogenic zone short before birth and the vanishing of all stem cell niches aligned beyond the organ capsule. There is evidence that molecular controlling of this normal but degenerative developmental process also plays a decisive role in the kidneys of preterm and growth restricted babies...
July 12, 2017: Drug Research
https://www.readbyqxmd.com/read/28699359/mitochondrial-uptake-and-accumulation-of-vitamin-c-what-can-we-learn-from-cell-cultures-studies
#8
Orazio Cantoni, Andrea Guidarelli, Mara Fiorani
SIGNIFICANCE: The mitochondrial fraction of L-ascorbic acid (AA) is of critical importance for the regulation of the redox status of these organelles and for cell survival. Recent Advances: Most cell types take up AA by high affinity sodium-dependent vitamin C transporter 2 (SVCT2), sensitive to inhibition by dehydroascorbic acid (DHA). DHA can also be taken up by glucose transporters (GLUTs) and then reduced back to AA. DHA concentrations, normally very low in biological fluids, may only become significant next to superoxide releasing cells...
July 12, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28698279/zika-virus-persistently-infects-and-is-basolaterally-released-from-primary-human-brain-microvascular-endothelial-cells
#9
Megan C Mladinich, John Schwedes, Erich R Mackow
Zika virus (ZIKV) is a mosquito-borne Flavivirus that has emerged as the cause of encephalitis and fetal microencephaly in the Americas. ZIKV uniquely persists in human bodily fluids for up to 6 months, is sexually transmitted, and traverses the placenta and the blood-brain barrier (BBB) to damage neurons. Cells that support persistent ZIKV replication and mechanisms by which ZIKV establishes persistence remain enigmatic but central to ZIKV entry into protected neuronal compartments. The endothelial cell (EC) lining of capillaries normally constrains transplacental transmission and forms the BBB, which selectively restricts access of blood constituents to neurons...
July 11, 2017: MBio
https://www.readbyqxmd.com/read/28697873/toxoplasma-gondii-seroprevalence-and-association-with-equine-protozoal-myeloencephalitis-a-case-control-study-of-californian-horses
#10
K E James, W A Smith, A E Packham, P A Conrad, N Pusterla
While toxoplasmosis is not commonly considered a clinical disease of equines, previous seroprevalence studies have reported differing background rates of Toxoplasma gondii infection in horses globally. The objective of this study was to evaluate possible associations between T. gondii seroprevalence and clinical signs of equine protozoal myeloencephalitis (EPM) in horses. Using a case-control study design, 720 Californian horses with neurologic signs compatible with EPM were compared to healthy, non-neurologic horses for the presence of T...
June 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28695992/optimal-radiotherapy-target-volumes-in-intracranial-nongerminomatous-germ-cell-tumors-long-term-institutional-experience-with-chemotherapy-surgery-and-dose-and-field-adapted-radiotherapy
#11
William G Breen, Miran J Blanchard, Amulya Nageswara Rao, David J Daniels, Jan C Buckner, Nadia N Issa Laack
PURPOSE: To evaluate patterns of failure after multimodality treatment of nongerminomatous germ cell tumors (NGGCTs). MATERIALS AND METHODS: We retrospectively reviewed records of 3,440 patients diagnosed with primary intracranial NGGCT between 1988 and 2014. RESULTS: Thirty-four patients received induction chemotherapy followed by radiation with or without surgery. Median follow-up was 11.1 years (0.8-23.3). Outcomes were significantly improved in these 34 patients (5-year overall survival [OS]: 88% versus 50%, P = 0...
July 11, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28695434/the-single-nucleotide-polymorphism-snp-of-tumor-necrosis-factor-%C3%AE-308g-a-gene-is-associated-with-early-onset-primary-knee-osteoarthritis-in-an-egyptian-female-population
#12
Sahar M Abdel Galil, Nillie Ezzeldin, Faten Fawzy, Mohamed El-Boshy
The objective of the present study is to investigate if there is a potential association between the single-nucleotide polymorphisms (SNPs) of the tumor necrosis factor alpha gene (TNF-α -308G/A, rs1800629) and the susceptibility to and severity of early-onset knee osteoarthritis in the Egyptian female population. Genotype distributions and allelic frequencies of TNF-α -308G/A polymorphism were investigated in 210 knee osteoarthritis (OA) patients and 210 age-, sex-, and ethnicity-matched healthy controls (HC)...
July 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28695198/neat-monolayer-tiling-of-molecularly-thin-two-dimensional-materials-in-1-min
#13
Kazuaki Matsuba, Chengxiang Wang, Kazuko Saruwatari, Yusuke Uesusuki, Kosho Akatsuka, Minoru Osada, Yasuo Ebina, Renzhi Ma, Takayoshi Sasaki
Controlled arrangement of molecularly thin two-dimensional (2D) materials on a substrate, particularly into precisely organized mono- and multilayer structures, is a key to design a nanodevice using their unique and enhanced physical properties. Several techniques such as mechanical transfer process and Langmuir-Blodgett deposition have been applied for this purpose, but they have severe restrictions for large-scale practical applications, for example, limited processable area and long fabrication time, requiring skilled multistep operations...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28694602/pseudarthrosis-due-to-galvanic-corrosion-presenting-as-subarachnoid-hemorrhage
#14
Rosemary Noel Beavers, Rishi Rajiv Lall, Juan Ortega Barnett, Sohum Kiran Desai
Two unlike metals near one another can break down as they move toward electrochemical equilibrium resulting in galvanic corrosion. We describe a case of electrochemical corrosion resulting in pseudarthrosis, followed by instrumentation failure leading to subarachnoid hemorrhage. A 53-year-old female with a history of cervical instability and two separate prior cervical fusion surgery with sublaminar cables presented with new onset severe neck pain. Restricted range of motion in her neck and bilateral Hoffman's was noted...
April 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/28693588/cxcl11-production-in-cerebrospinal-fluid-distinguishes-herpes-simplex-meningitis-from-herpes-simplex-encephalitis
#15
Liza Lind, Marie Studahl, Linn Persson Berg, Kristina Eriksson
BACKGROUND: The closely related herpes simplex viruses 1 and 2 can cause inflammations of the central nervous system (CNS), where type 1 most often manifest as encephalitis (HSE), and type 2 as meningitis (HSM). HSE is associated with severe neurological complications, while HSM is benign in adults. We proposed that studying the chemokine and cytokine production in cerebrospinal fluid (CSF) and serum could indicate why two closely related viruses exhibit different severity of their accompanied CNS inflammation...
July 10, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28691322/bile-acid-levels-and-risk-of-adverse-perinatal-outcomes-in-intrahepatic-cholestasis-of-pregnancy-a-meta-analysis
#16
Donghua Cui, Yongxing Zhong, Lin Zhang, Hechun Du
AIM: We aimed to determine the association between maternal total bile acid (TBA) levels and the risks of adverse perinatal outcomes in pregnant women with intrahepatic cholestasis of pregnancy (ICP) based on a meta-analysis study. METHODS: We searched PubMed for articles published from 2000 to 2015 with a focus on ICP and restriction to the English language. The main perinatal outcomes were preterm birth (PTB), meconium-stained amniotic fluid (MSAF), asphyxia, or respiratory distress syndrome (RDS)...
July 10, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28691040/flow-cytometry-of-lung-and-bronchoalveolar-lavage-fluid-cells-from-mice-challenged-with-fluorescent-aspergillus-reporter-flare-conidia
#17
Anupam Jhingran, Shinji Kasahara, Tobias M Hohl
Aspergillus fumigatus is a ubiquitous fungal pathogen that forms airborne conidia. The process of restricting conidial germination into hyphae by lung leukocytes is critical in determining infectious outcomes. Tracking the outcome of conidia-host cell encounters in vivo is technically challenging and an obstacle to understanding the molecular and cellular basis of antifungal immunity in the lung. Here, we describe a method that utilizes a genetically engineered Aspergillus strain [called FLARE (Jhingran et al...
September 20, 2016: Bio-protocol
https://www.readbyqxmd.com/read/28685262/urinary-leakage-during-exercise-problematic-activities-adaptive-behaviors-and-interest-in-treatment-for-physically-active-canadian-women
#18
Erin Brennand, Eider Ruiz-Mirazo, Selphee Tang, Shunaha Kim-Fine
INTRODUCTION AND HYPOTHESIS: Urine loss during recreational exercise is problematic. We aimed to characterize which activities are most frequently reported as causing leakage for women, adaptive management mechanisms, and awareness and interest in treatment in a cohort of physically active women. METHODS: We administered an anonymous questionnaire to 59 physically active women in Canada. Surveys were completed electronically or on paper. Demographic information was obtained...
July 6, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28684015/bioimpedance-spectroscopy-measurements-of-phase-angle-and-height-for-age-are-predictive-of-outcome-in-children-following-surgery-for-congenital-heart-disease
#19
L V Marino, R Meyer, M Johnson, C Newell, C Johnstone, A Magee, K Sykes, S A Wootton, J V Pappachan
OBJECTIVE: Children with congenital heart disease (CHD) are often growth restricted (low weight- and/or height-for-age) which may increase risk of poor post operative resilience. Bioelectrical impedance spectroscopy (BIS) has been used to determine body composition in different clinical settings and has been shown to mark differences in nutritional state and clinical outcome. In disease conditions were fluid is not normally distributed it is proposed that raw impedance values and BIS derived phase-angle may serve as prognostic indicators of clinical outcome...
June 28, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28678497/excited-state-dynamics-of-a-photobiologically-active-ru-ii-dyad-are-altered-in-biologically-relevant-environments
#20
Christian Reichardt, Kilian R A Schneider, Tariq Sainuddin, Maria Wächtler, Sherri A McFarland, Benjamin Dietzek
In this study femtosecond and nanosecond time-resolved transient absorption spectroscopy was used to investigate the influence of ionic strength and complexity on the excited state dynamics of a Ru(II)-based metal-organic dyad. The bis-heteroleptic complex [Ru(bpy)2(ippy)]2+ (1), where bpy=2,2'-bipyridine and ippy=2-(1-pyrenyl-1H-imidazo[4,5-f][1,10]phenanthroline, is a potent photosensitizer for in vitro photodynamic therapy (PDT) and photodynamic inactivation (PDI) of microorganisms owing to a long-lived triplet excited state derived from a metal-to-ligand charge transfer (3MLCT) state that is equilibrium with an intraligand (3IL) state...
July 5, 2017: Journal of Physical Chemistry. A
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