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https://www.readbyqxmd.com/read/29924962/prognostic-value-of-aldehyde-dehydrogenase-1-aldh1-in-invasive-breast-carcinomas
#1
Hale Demir, Ozgecan Dulgar, Bugra Taygun Gulle, Hande Turna, Sennur Ilvan
Aldehyde dehydrogenase 1 (ALDH1) has been identified as a marker of cancer stem cells in breast cancer (BC). Recent studies showed that ALDH1 expression is correlated with poor prognostic parameters and worse clinical outcome in BC. We evaluated ALDH1 expression by immunohistochemistry in a series of 217 invasive BCs and investigated the correlation between ALDH1 expression and clinicopathological parameters, molecular subtypes (luminal A, luminal B, human epidermal growth factor receptor 2 [HER2] type, and triple-negative BC [TNBC]), and patient survival...
June 11, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29924228/exuberant-case-of-cutaneous-metastasis-of-breast-cancer
#2
Vítor Angelo Ferreira, Karla Spelta, Lucia Martins Diniz, Elton Almeida Lucas
Cutaneous metastasis is the main cause of morbidity and mortality of cancer patients, denoting a guarded prognosis. The clinical spectrum of the disease is broad and can mimic benign conditions. The diagnosis depends on thorough clinical examination and complementary exams, with emphasis on the histopathological study and immunohistochemistry. Because it indicates a systemic relapse, it is necessary to intervene with intravenous chemotherapy, to which local therapies can be associated. We report the case of a 65-year-old woman with cutaneous metastasis from breast cancer treated 14 years back, manifested by extensive firm and infiltrated red-purple plaques on the sides of the trunk, with a course of six months...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29923514/whole-body-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-18-f-fdg-pet-ct-for-staging-locally-advanced-breast-cancer-a-prospective-study-from-a-tertiary-cancer-centre-in-south-india
#3
Sivanath Reddy Gajjala, Narendra Hulikal, Silpa Kadiyala, Radhika Kottu, Tekchand Kalawat
Background & objectives: Locally advanced breast cancer (LABC) is associated with substantial risk of occult metastases. The patients with LABC have high rate of systemic relapse, suggesting inadequacy of the current conventional staging in detecting the occult metastatic spread. 18 F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) is a new modality in the staging of breast cancer patients. Hence, this study was conducted to evaluate the role of 18 F-FDG PET/CT in initial staging of LABC and to compare it with conventional methods...
March 2018: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29923327/survival-benefit-of-sphingosin-1-phosphate-and-receptors-expressions-in-breast-cancer-patients
#4
Fu-Ju Lei, Bi-Hua Cheng, Pei-Yin Liao, Hsiao-Ching Wang, Wei-Chun Chang, Hsueh-Chou Lai, Juan-Cheng Yang, Yang-Chang Wu, Li-Ching Chu, Wen-Lung Ma
Sphingosine-1-phosphate (S1P) is a bioactive lipid that exerts various pathophysiological functions through binding to its receptor family (S1PRs). Since first report of the breast cancer (BCA) promoting function by S1P production (through the function of sphingosine kinases) and S1P/S1PR signaling, their antagonists have never been successfully progress to clinics after three decades. Taking advantage of bioinformatics linking to gene expression to disease prognosis, we examined the impact of associated genes in BCA patients...
June 20, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29923188/stop-routine-screening-for-associated-malignancies-in-cutaneous-non-invasive-vulvar-paget-disease
#5
M van der Linden, M S Schuurman, J Bulten, L F A G Massuger, J IntHout, M A van der Aa, J A de Hullu
BACKGROUND: Vulvar Paget disease (VPD) is extremely rare and thought to be associated with other malignancies. OBJECTIVE: The aim of this study was to evaluate the risk of developing breast, intestinal, and urological malignancies in patients with VPD compared with the general population, and in particular focus on the risk of malignancy in patients with cutaneous non-invasive VPD. METHODS: Data on the oncologic history of patients with any type of VPD between 2000 and 2015 were obtained from PALGA, a nationwide archive containing all pathology reports in the Netherlands...
June 19, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29923083/micrornas-in-regulation-of-triple-negative-breast-cancer-progression
#6
REVIEW
Dominika Piasecka, Marcin Braun, Radzislaw Kordek, Rafal Sadej, Hanna Romanska
PURPOSE: Dysregulation of miRNA profile has been associated with a broad spectrum of cellular processes underlying progression of various human malignancies. Increasing evidence suggests that specific microRNA clusters might be of clinical utility, especially in triple-negative breast carcinoma (TNBC), devoid of both predictive markers and potential therapeutic targets. Here we provide a comprehensive review of the existing data on microRNAs in TNBC, their molecular targets, a putative role in invasive progression with a particular emphasis on the epithelial-to-mesenchymal transition (EMT) and acquisition of stem-cell properties (CSC), regarded both as prerequisites for metastasis, and significance for therapy...
June 19, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29923063/persistent-major-alopecia-following-adjuvant-docetaxel-for-breast-cancer-incidence-characteristics-and-prevention-with-scalp-cooling
#7
M Martín, J C de la Torre-Montero, S López-Tarruella, K Pinilla, A Casado, S Fernandez, Y Jerez, J Puente, I Palomero, R González Del Val, M Del Monte-Millan, T Massarrah, C Vila, B García-Paredes, J A García-Sáenz, A Lluch
BACKGROUND: Persistent alopecia (PA) after docetaxel has been recently described. The aim of our study is to establish the incidence and characteristics of PA following adjuvant docetaxel for breast cancer (BC) and to test the ability of scalp cooling in prevention. PATIENTS AND METHODS: BC patients receiving adjuvant chemotherapy followed or not by endocrine therapy (and a control group receiving only endocrine therapy) were interviewed in a single institution at 1...
June 19, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29923058/evaluation-breast-cancer-information-on-the-internet-in-arabic
#8
Lamya Alnaim
Nowadays, medical information regarding various diseases and disorders is available online. The Internet has become the first choice for the patient when it comes to gathering detailed information about a disease or problem. Therefore, in view of this frequent occurrence, the information that is provided online needs to be accurate; providing comprehensive facts, transparency, and quality. A study was carried out to determine the accuracy of information related to breast cancer on various websites. Websites which share information online about breast cancer, in the Arabic language, were selected...
June 20, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29922963/endocrine-treatment-of-aging-transgender-people
#9
REVIEW
Louis J Gooren, Guy T'Sjoen
High quality empirical data assessing morbidity and mortality and cancer incidence among transgender people are almost non-existent. Sex hormone treatment of conditions in older non-transgender people might as yet be taken as the best available analogy to hormone administration to aging transgender persons. Testosterone administration to transgender men carries little risk with regard to cardiovascular disease and cancer. A dose adaptation may be needed in men with a high hematocrit or cardiac insufficiency...
June 19, 2018: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/29922710/aspirin-use-correlates-with-survival-in-women-with-clear-cell-ovarian-cancer
#10
Alyssa M Wield, Christine S Walsh, B J Rimel, Ilana Cass, Beth Y Karlan, Andrew J Li
Data from colon, breast and prostate cancers suggest that aspirin users have reduced mortality. While the direct mechanism remains uncertain, aspirin can suppress the COX-dependent and independent pathways involved in tumor progression. We hypothesized that aspirin users with clear cell ovarian cancer would have improved survival outcomes. We performed a retrospective review of patients with clear cell ovarian cancer diagnosed between 1995 and 2010, and followed outcomes through 2016. Patients underwent primary cytoreductive surgery followed by platinum-based chemotherapy...
August 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29922160/decost-a-new-approach-in-drug-repurposing-from-control-system-theory
#11
Thanh M Nguyen, Syed A Muhammad, Sara Ibrahim, Lin Ma, Jinlei Guo, Baogang Bai, Bixin Zeng
In this paper, we propose DeCoST (Drug Repurposing from Control System Theory) framework to apply control system paradigm for drug repurposing purpose. Drug repurposing has become one of the most active areas in pharmacology since the last decade. Compared to traditional drug development, drug repurposing may provide more systematic and significantly less expensive approaches in discovering new treatments for complex diseases. Although drug repurposing techniques rapidly evolve from "one: disease-gene-drug" to "multi: gene, dru" and from "lazy guilt-by-association" to "systematic model-based pattern matching," mathematical system and control paradigm has not been widely applied to model the system biology connectivity among drugs, genes, and diseases...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29922090/extramedullary-hematopoiesis-secondary-to-malignant-solid-tumors-a-case-report-and-literature-review
#12
Youting Bao, Zhichao Liu, Meiying Guo, Butuo Li, Xindong Sun, Linlin Wang
Extramedullary hematopoiesis (EMH) usually occurs in hematological disease, but more rarely develops in cases of malignant solid tumors. Due to its features on computed tomography (CT) and magnetic resonance imaging (MRI) that are atypical, EMH in tumor patients might easily be misdiagnosed as metastasis leading to the improper TNM staging and inappropriate therapy. Here, we reported the first case of pleural EMH occurring in a patient with esophageal carcinoma whose pleural lesion was first diagnosed as metastasis and confirmed EMH after the needle biopsy...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29922076/prognostic-value-of-spleen-tyrosine-kinase-in-human-solid-tumors
#13
Beibei Ni, Shi Li, Yang Liu, Yuqian Huang, Zesong Li
Background: Spleen tyrosine kinase (SYK) was reported to be dysregulated in solid tumors and played an important role in cancer progression. However, the clinical and prognostic values of SYK in solid tumors remain unclear. This meta-analysis investigated the association between SYK expression and clinical outcomes in the patients with solid tumors. Methods: A comprehensive literature search was conducted by screening the online electronic databases of PubMed, Embase, and the China National Knowledge Infrastructure...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29921732/chemotherapy-sensitizes-therapy-resistant-cells-to-mild-hyperthermia-by-suppressing-heat-shock-protein-27-expression-in-triple-negative-breast-cancer
#14
Haifa Shen, Chaofeng Mu, Xiaoyan Wu, Xinyu Zhou, Joy Wolfram, Jianliang Shen, Dechen Zhang, Junhua Mai, Xiaojun Xia, Ashley M Holder, Mauro Ferrari, Xuewu Liu
PURPOSE: Triple-negative breast cancer (TNBC) is a clinically aggressive disease with poor prognosis. Conventional chemotherapeutics are generally able to shrink the tumor mass, but often fail to completely eradicate cancer stem-like cells (CSCs) that are responsible for high risk of relapse and frequent metastases. In this study, we examined thermal sensibility of CSCs, developed an approach that enabled concurrent elimination of both the bulk of cancer cells and CSCs, and investigated the underlying mechanism...
June 19, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29921729/integrating-radiosensitivity-and-immune-gene-signatures-for-predicting-benefit-of-radiotherapy-in-breast-cancer
#15
Yi Cui, Bailiang Li, Erqi Liu Pollom, Kathleen Horst, Ruijiang Li
PURPOSE: Breast cancer is a heterogeneous disease and not all patients respond equally to adjuvant radiotherapy. Predictive biomarkers are needed to select patients who will benefit from the treatment and spare others the toxicity and burden of radiation. EXPERIMENTAL DESIGN: We first trained and tested an intrinsic radiosensitivity gene signature to predict local recurrence after radiotherapy in three cohorts of 948 patients. Next, we developed an antigen processing and presentation-based immune signature by maximizing the treatment interaction effect in 129 patients...
June 19, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29921699/tumor-educated-platelets-as-a-noninvasive-biomarker-source-for-cancer-detection-and-progression-monitoring
#16
REVIEW
Myron G Best, Pieter Wesseling, Thomas Wurdinger
Liquid biopsies represent a potential revolution in cancer diagnostics as a noninvasive method for detecting and monitoring diseases, complementary to or even replacing current tissue biopsy approaches. Several blood-based biosources and biomolecules, such as cell-free DNA and RNA, proteins, circulating tumor cells, and extracellular vesicles, have been explored for molecular test development. We recently discovered the potential of tumor-educated blood platelets (TEP) as a noninvasive biomarker trove for RNA biomarker panels...
June 19, 2018: Cancer Research
https://www.readbyqxmd.com/read/29921457/association-of-elevated-levels-of-c-reactive-protein-with-breast-cancer-breast-cancer-subtypes-and-poor-outcome
#17
Raman Preet Kaur, Rubal, Raja Paramjeet Singh Banipal, Rajesh Vashistha, Monisha Dhiman, Anjana Munshi
BACKGROUND AND PURPOSE: Inflammation and caner are linked in a bidirectional manner. C-reactive protein (CRP) is an important inflammatory marker. The aim of the study was to test whether the inflammatory marker, CRP at the time of diagnosis of breast cancer is associated with metastasis, recurrence, and death in breast cancer patients from Malwa region of Punjab where breast cancer is widely feared. MATERIAL AND METHODS: Two hundred and forty-two breast cancer patients and 242 age and sex matched controls were included in the study...
May 25, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29921315/expression-of-id4-protein-in-breast-cancer-cells-induces-reprogramming-of-tumour-associated-macrophages
#18
Sara Donzelli, Elisa Milano, Magdalena Pruszko, Andrea Sacconi, Silvia Masciarelli, Ilaria Iosue, Elisa Melucci, Enzo Gallo, Irene Terrenato, Marcella Mottolese, Maciej Zylicz, Alicja Zylicz, Francesco Fazi, Giovanni Blandino, Giulia Fontemaggi
BACKGROUND: As crucial regulators of the immune response against pathogens, macrophages have been extensively shown also to be important players in several diseases, including cancer. Specifically, breast cancer macrophages tightly control the angiogenic switch and progression to malignancy. ID4, a member of the ID (inhibitors of differentiation) family of proteins, is associated with a stem-like phenotype and poor prognosis in basal-like breast cancer. Moreover, ID4 favours angiogenesis by enhancing the expression of pro-angiogenic cytokines interleukin-8, CXCL1 and vascular endothelial growth factor...
June 19, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29917326/replacement-and-desmoplastic-histopathological-growth-patterns-a-pilot-study-of-prediction-of-outcome-in-patients-with-uveal-melanoma-liver-metastases
#19
Raymond Barnhill, Peter Vermeulen, Sofie Daelemans, Pieter-Jan van Dam, Sergio Roman-Roman, Vincent Servois, Ilse Hurbain, Sophie Gardrat, Graça Raposa, Nicolas André, Rémi Dendale, Gaëlle Pierron, Laurence Desjardins, Nathalie Cassoux, Sophie Piperno-Neumann, Pascale Mariani, Claire Lugassy
Up to 50% of uveal melanomas (UM) metastasize to the liver within 10 years of diagnosis, and these almost always prove rapidly fatal. Since histopathological growth patterns (HGP) of liver metastases of the replacement and desmoplastic type, particularly from colon and breast carcinoma, may import valuable biological and prognostic information, we have studied HGP in a series of 41 UM liver metastases originating from 41 patients from the period 2006-2017. Twenty patients underwent enucleation while 21 had radiation therapy...
June 19, 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29917175/-breast-implant-associated-anaplastic-large-cell-lymphoma-bia-alcl
#20
Per Hedén, Birgit Stark
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a distinct type of T-cell lymphoma, developing around implants, that can occur 2 to 25 years (median 8 years) post-implantation. Most patients present with a swelling of the breast, which is usually associated with pain and fluid collecting around the implant. Less commonly, a lump in the breast and/or in the axilla can be present. A periprosthetic fluid collection (> 1 year post-implantation) should be investigated with ultrasound and fine needle aspiration...
June 12, 2018: Läkartidningen
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