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https://www.readbyqxmd.com/read/29138376/-the-changes-in-the-neutrophil-to-lymphocyte-ratio-can-predict-the-timing-of-chemotherapeutic-regimen-alteration-in-patients-with-metastatic-colorectal-cancer
#1
Katsuki Muneoka, Yoshio Shirai, Masataka Sasaki, Shinsuke Honma, Jun Sakata, Junkichi Kanda, Hiroyuki Wakabayashi, Toshifumi Wakai
AIM: In order to determine if the changes in the neutrophil-to-lymphocyte ratio(NLR)can predict the timingof regimen alteration, the outcome of chemotherapy for metastatic colorectal cancer was analyzed retrospectively. METHODOLOGY: Thirty patients with unresectable metastatic colorectal cancer were administered chemotherapy from January 2005 to December 2015 at the Niitsu Medical Center Hospital. The NLR was calculated from complete blood counts obtained prior to administration of chemotherapy and at the time of the best response...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29135093/evaluation-of-safety-of-bevacizumab-as-second-line-treatment-of-patients-with-metastatic-colorectal-cancer
#2
Vladimir Todorovic, Nada Cicmil Saric, Jadranka Lakicevic, Milan Sorat
PURPOSE: Bevacizumab is a relatively new monoclonal antibody introduced in the treatment of metastatic colorectal cancer (CRC). Since varied efficiency and adverse events of this drug were reported, the purpose of this study was to assess the safety of bevacizumab as second-line treatment of patients with metastatic CRC. METHODS: This observational, non-interventional study involved 35 patients with metastatic CRC treated with bevacizumab. Patients were from the Oncology Clinic, Clinical Centre of Montenegro...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29123975/distribution-of-lewis-and-secretor-polymorphisms-and-corresponding-ca19-9-antigen-expression-in-a-chinese-population
#3
Meng Guo, Guopei Luo, Renquan Lu, Weizhong Shi, He Cheng, Yu Lu, Kaizhou Jin, Chao Yang, Zhengshi Wang, Jiang Long, Jin Xu, Quanxing Ni, Chen Liu, Xianjun Yu
The Lewis (FUT3) and Secretor (FUT2) genes, corresponding to secretion of Lewis ABO (H) histo-blood group antigen CA19-9, are highly polymorphic with differences between populations. In this study, the FUT3 and FUT2 genes in 316 Chinese participants were sequenced to detect polymorphisms, and the associated CA19-9 antigen secretion was also measured. In total, 14 genotypes of FUT3 and 10 genotypes of FUT2 were verified. Le/Le, Le/le(59,508) and Le/le(59) were the main genotypes of FUT3 with frequencies of 53...
November 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/29123261/a-new-panel-of-pancreatic-cancer-biomarkers-discovered-using-a-mass-spectrometry-based-pipeline
#4
Xiaohui Liu, Weimin Zheng, Wansheng Wang, Huali Shen, Linxiao Liu, Wenhui Lou, Xiaolin Wang, Pengyuan Yang
BACKGROUND: Pancreatic carcinoma (PC) is an aggressive malignancy that lacks strategies for early detection. This study aimed to develop a coherent, high-throughput and non-discriminatory pipeline for the novel clinical biomarker discovery of PC. METHODS: We combined mass spectrometry (MS)-intensive methods such as isobaric tags for relative and absolute quantitation with two-dimensional liquid chromatography-tandem mass spectrometry (iTRAQ-2DLC-MS/MS), 1D-targeted LC-MS/MS, prime MRM (P-MRM) and stable isotope dilution-based MRM (SID-MRM) to analyse serum samples from healthy people (normal control, NC), patients with benign diseases (BD) and PC patients to identify novel biomarkers of PC...
November 9, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29121872/diagnostic-and-prognostic-value-of-cea-ca19-9-afp-and-ca125-for-early-gastric-cancer
#5
Fan Feng, Yangzi Tian, Guanghui Xu, Zhen Liu, Shushang Liu, Gaozan Zheng, Man Guo, Xiao Lian, Daiming Fan, Hongwei Zhang
BACKGROUND: The diagnostic and prognostic significance of carcinoembryonic antigen (CEA), carbohydrate associated antigen 19-9 (CA19-9), alpha-fetoprotein (AFP) and cancer antigen 125 (CA125) in early gastric cancer have not been investigated yet. Thus, the present study aimed to explore the diagnostic and prognostic significance of the four tumor markers for early gastric cancer. METHODS: From September 2008 to March 2015, 587 early gastric cancer patients were given radical gastrectomy in our center...
November 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29119533/18-fluorodeoxyglucose-positron-emission-tomography-predicts-recurrence-in-resected-pancreatic-ductal-adenocarcinoma
#6
Kyohei Ariake, Fuyuhiko Motoi, Hideo Shimomura, Masamichi Mizuma, Shimpei Maeda, Chiaki Terao, Yasuko Tatewaki, Hideo Ohtsuka, Koji Fukase, Kunihiro Masuda, Hiroki Hayashi, Tatsuyuki Takadate, Takeshi Naitoh, Yasuyuki Taki, Michiaki Unno
BACKGROUND: We aimed to determine whether treatment should be stratified according to 18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) maximum standardized uptake values (SUVmax) in pancreatic ductal adenocarcinoma. METHODS: Patients who underwent preoperative 18F-FDG PET/CT between 2006 and 2014 (n = 138) were stratified into high (≥ 4.85) and low (< 4.85) PET groups. The clinicopathological characteristics and prognostic outcomes were analyzed retrospectively...
November 8, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29116068/-hydrogel-microchip-as-a-tool-for-studying-exosomes-in-human-serum
#7
V I Butvilovskaya, A A Tikhonov, E N Savvateeva, A A Ragimov, E L Salimov, S A Voloshin, D V Sidorov, M A Chernichenko, A P Polyakov, M M Filushin, M V Tsybulskaya, A Yu Rubina
Exosomes are cell-derived vesicles that are secreted by both normal and cancer cells. Over the last decade, a few studies have revealed that exosomes cross talk and/or influence major tumor-related pathways such as angiogenesis and metastasis involving many cell types within the tumor microenvironment. The protein composition of the membrane of an exosome reflects that of the membrane of the cell of origin. Because of this, tumor-derived exosomes differ from exosomes that are derived from normal cells. The detection of tumor exosomes and analysis of their molecular composition hold promise for diagnosis and prognosis of cancer...
September 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/29113658/circulating-cell-free-dna-in-plasma-of-colorectal-cancer-patients-a-potential-biomarker-for-tumor-burden
#8
Jagdeep Singh Bhangu, Hossein Taghizadeh, Tamara Braunschmid, Thomas Bachleitner-Hofmann, Christine Mannhalter
BACKGROUND: Measurement of cell-free DNA (cfDNA) in plasma - the so called liquid biopsy - is a novel method for early detection of cancer. Necrotic cancer cells release various DNA fragments that can be detected in plasma or serum. The aim of our study was to investigate the concentration of circulating ALU115, LINE79 and LINE297 fragments in plasma from venous and arterial blood of colorectal cancer (CRC) patients before, during and 5 days after surgical intervention. PATIENTS AND METHODS: Thirty patients (16 female, 14 male, median age 56 years), undergoing surgery for colorectal and appendix cancer, and 17 healthy volunteers were included in this study...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29103773/kras-mutation-and-immunohistochemical-profile-in-intraductal-papillary-neoplasm-of-the-intrahepatic-bile-ducts
#9
Zhi-Hong Xian, Chun Qin, Wen-Ming Cong
Intraductal papillary neoplasm of bile duct (IPNB) is characterized by a spectrum of diseases ranging from low-grade intraepithelial neoplasia to invasive carcinoma. In the present study, we aimed to investigate immunophenotypic features and KRAS mutations in relation to pathological subtypes and grades in Chinese patients with IPNBs. A total of 46 patients with IPNBs and 11 invasive adenocarcinomas arising in IPNBs (invasive IPNBs) were enrolled and clinicopathological data were analyzed. It was found that CK7 was expressed in 42 of the 46 neoplastic lesions...
October 18, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29100454/peritoneal-recurrence-in-gastric-cancer-following-curative-resection-can-be-predicted-by-postoperative-but-not-preoperative-biomarkers-a-single-institution-study-of-320-cases
#10
Fan Wu, Chunmei Shi, Riping Wu, Zhiqing Huang, Qiang Chen
To determine the risk factors for peritoneal recurrence in gastric cancer patients after curative resection, we included 320 patients with stage I-III primary gastric cancer between January 2008 and June 2012. Data on each patient's surgical and pathological information, preoperative and postoperative tumor markers were collected and analyzed retrospectively. The risk factors for peritoneal recurrence were investigated by univariate and multivariate analysis. In patients with peritoneal recurrence, advanced T or N stage, low differentiation, vascular/lymphatic invasion, perineural invasion, and elevated postoperative CEA/CA19-9 were more common than in patients without peritoneal recurrence...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29072678/specific-detection-of-soluble-epha2-fragments-in-blood-as-a-new-biomarker-for-pancreatic-cancer
#11
Naohiko Koshikawa, Tomoko Minegishi, Hirofumi Kiyokawa, Motoharu Seiki
Because membrane type 1-matrix metalloproteinase 1 (MT1-MMP) and erythropoietin-producing hepatocellular receptor 2 (EphA2) expression are upregulated by the Ras/mitogen-activated protein kinase pathway, they are frequently coexpressed in malignant tumors. MT1-MMP cleaves the N-terminal ligand-binding domain of EphA2 and inactivates its ligand-dependent tumor-suppressing activity. Therefore, specific detection of the cleaved N-terminal EphA2 fragment in blood might be an effective biomarker to diagnose malignant tumors...
October 26, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29072130/glycoprotein-ca19-9-specific-monoclonal-antibodies-recognize-sialic-acid-independent-glycotope
#12
Manoj Chugh, Vladimir Piskarev, Oxana Galanina, Nailya Khasbiullina, Pallavi Kadam, Nadezhda Shilova, Galina Pazynina, Kira Dobrochaeva, Paresh Bhanushali, Nikolay Kozlov, Nikolay Tupitsin, Nicolai Bovin
A repertoire of monoclonal antibodies was generated by immunization of mice with cancer-associated glycoprotein CA19.9, and two of them were selected as optimal capture and detecting counterparts for sandwich test system for detection of CA19.9. Fine epitope specificity of the antibodies was determined using printed glycan array, enzyme-linked immunosorbent assay, and inhibitory enzyme-linked immunosorbent assay. Unexpectedly, both immunoglobulins did not bind key epitope of CA19.9 glycoprotein, tetrasaccharide SiaLe(A), as well as its defucosylated form sialyl Le(C) (known as CA-50 epitope)...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29068419/fgf-2b-and-h-pl-transform-duct-and-non-endocrine-human-pancreatic-cells-into-endocrine-insulin-secreting-cells-by-modulating-differentiating-genes
#13
Giulia Donadel, Donatella Pastore, David Della-Morte, Barbara Capuani, Marco F Lombardo, Francesca Pacifici, Marco Bugliani, Fabio A Grieco, Piero Marchetti, Davide Lauro
Background: Diabetes mellitus (DM) is a multifactorial disease orphan of a cure. Regenerative medicine has been proposed as novel strategy for DM therapy. Human fibroblast growth factor (FGF)-2b controls β-cell clusters via autocrine action, and human placental lactogen (hPL)-A increases functional β-cells. We hypothesized whether FGF-2b/hPL-A treatment induces β-cell differentiation from ductal/non-endocrine precursor(s) by modulating specific genes expression. Methods: Human pancreatic ductal-cells (PANC-1) and non-endocrine pancreatic cells were treated with FGF-2b plus hPL-A at 500 ng/mL...
October 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29063056/comparison-of-627-patients-with-right-and-left-sided-colon-cancer-in-china-differences-in-clinicopathology-recurrence-and-survival
#14
Qiong Qin, Lin Yang, Yong-Kun Sun, Jian-Ming Ying, Yan Song, Wen Zhang, Jin-Wan Wang, Ai-Ping Zhou
OBJECTIVE: Recent studies have reported increased mortality for right-sided colon cancers; however, the results are conflicting for different stage tumors. We examined the differences in clinicopathology between right- and left-sided colon cancers and the relationships between colon cancer location (right- and left-side) and 5-year disease-free survival (DFS) and overall survival (OS). METHODS: We identified patients from 2005 to 2008 with stage II/III colon cancer who underwent surgery for curative intent...
March 25, 2017: Chronic Dis Transl Med
https://www.readbyqxmd.com/read/29052791/potential-diagnostic-performance-of-contrast-enhanced-ultrasound-and-tumor-markers-in-differentiating-combined-hepatocellular-cholangiocarcinoma-from-hepatocellular-carcinoma-and-cholangiocarcinoma
#15
Xiao-Wen Huang, Yang Huang, Li-da Chen, Zhu Wang, Zheng Yang, Jin-Ya Liu, Xiao-Yan Xie, Ming-De Lu, Shun-Li Shen, Wei Wang
PURPOSE: To evaluate the diagnostic performance of the combination of tumor markers [alpha-fetoprotein (AFP) and carbohydrate antigen 19-9 (CA19-9)] and imaging features in differentiating combined hepatocellular-cholangiocarcinoma (CHC) from hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). METHODS: Forty consecutive patients with pathologically proven CHC were retrospectively evaluated with contrast-enhanced ultrasound (CEUS). Additionally, 40 HCC and 40 CC patients who were randomly selected from the same period served as a control group...
October 20, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29050756/clinical-significance-of-serum-ca-125-ca19-9-and-cea-in-pulmonary-tuberculosis-with-and-without-type-2-diabetes
#16
Zhi-Xiang Du, Man-Man Liang, Jing Sun, Wen-Jie Wang, Yin-Hua Liu, Jiang-Hua Yang
No abstract text is available yet for this article.
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29050465/epidermoid-splenic-cyst-with-elevated-serum-level-of-ca19-9
#17
Natalia Buda, Anna Wszołek, Maciej Śledziński, Anton Żawrocki, Krzysztof Sworczak
No abstract text is available yet for this article.
October 19, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29050291/natural-killer-cell-activity-for-ifn-gamma-production-as-a-supportive-diagnostic-marker-for-gastric-cancer
#18
Jongmi Lee, Ki Hyun Park, Ji Hyeong Ryu, Hyun Jin Bae, Aeran Choi, Hyeyoung Lee, Jihyang Lim, Kyungja Han, Cho Hyun Park, Eun Sun Jung, Eun-Jee Oh
BACKGROUND/AIM: Decreased Natural killer cell activity (NKA) for interferon-gamma production (NKA-IFNγ) has been reported in cancer patients. The aim of this study was to determine the diagnostic performance of NKA-IFNγ for gastric cancer (GC). RESULTS: NKA-IFNγ levels were decreased in 261 GC patients with all stages of tumor compared to those in 48 healthy donors (P < 0.001), and lower levels of NKA-IFNγ were associated with higher GC stages. NKA-IFNγ levels were also associated with clinicopathological parameters including tumor size, depth of invasion, and lymph node metastasis...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29044541/validation-of-sendai-and-fukuoka-consensus-guidelines-in-predicting-malignancy-in-patients-with-preoperatively-diagnosed-mucinous-pancreatic-cystic-neoplasms
#19
Wentao Zhou, Yadong Xu, Yefei Rong, Wenchuan Wu, Tiantao Kuang, Baobao Xin, Hongxu Zhu, Wenhui Lou, Dansong Wang
BACKGROUND AND OBJECTIVES: The Sendai consensus guidelines (SCG) and Fukuoka consensus guidelines (FCG) have been examined for their roles in predicting advanced neoplasia (AN) in pancreatic cystic neoplasm (PCN) patients with mixed results. We aim to evaluate the utilities of both guidelines in a Chinese cohort with preoperatively diagnosed mucinous PCNs. METHODS: One hundred ninety-seven patients who underwent resections from 2008 to 2015 in Zhong Shan Hospital, Fudan University for suspected PCNs were retrospectively reviewed...
October 16, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29043453/serum-carbohydrate-antigen-125-is-a-significant-prognostic-marker-in-patients-with-unresectable-advanced-or-recurrent-gastric-cancer
#20
Tsutomu Namikawa, Yasuhiro Kawanishi, Kazune Fujisawa, Eri Munekage, Jun Iwabu, Masaya Munekage, Hiromichi Maeda, Hiroyuki Kitagawa, Michiya Kobayashi, Kazuhiro Hanazaki
PURPOSE: We evaluated the diagnostic and prognostic value of three tumor markers: carcino-embryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and carbohydrate antigen 125 (CA125), in the pretreatment serum of patients with unresectable advanced or recurrent gastric cancer. METHODS: The subjects of this retrospective analysis were 245 patients with unresectable advanced or recurrent gastric cancer diagnosed at Kochi Medical School between 2007 and 2015. We ascertained the sensitivity of CEA, CA19-9, and CA125 to identify a certain survival time and then evaluated the relative prognosis of the patients...
October 17, 2017: Surgery Today
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