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https://www.readbyqxmd.com/read/28437802/surveillance-after-resection-of-pancreatic-ductal-adenocarcinoma-with-curative-intent-a-multicenter-survey-in-germany-and-review-of-the-literature
#1
Thomas J Ettrich, Lucas A Schulte, Natalie Eitel, Kristin Ettrich, Andreas W Berger, Lukas Perkhofer, Thomas Seufferlein
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with high risk of relapse even after curative-intended resection. There are no evidence-based recommendations for surveillance in actual guidelines. Given this situation and as a basis for prospective studies, we wanted to determine the current practice of surveillance after pancreatic cancer resection in German institutions. Methods A web-based questionnaire was sent in 2015 to 300 German institutions (hospitals, outpatient clinics, and private practices) experienced in the care of patients with PDAC...
April 24, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28434838/comment-re-optimize-ca19-9-in-detecting-pancreatic-cancer-by-lewis-and-secretor-genotyping
#2
EDITORIAL
A Wannhoff, K H Weiss, T Hackert, D N Gotthardt
No abstract text is available yet for this article.
April 12, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28434388/microrna-221-3p-is-up-regulated-and-serves-as-a-potential-biomarker-in-pancreatic-cancer
#3
Feng Li, Jian-Wei Xu, Lei Wang, Han Liu, Ye Yan, San-Yuan Hu
It has been demonstrated that circulating MicroRNAs (miRNAs) could be potential biomarkers for cancer diagnosis and prognosis. For pancreatic cancer (PCa), little is known about miR-221-3p biological function or its prognostic value. In the current study, we profiled miR-221-3p expression in PCa cell lines. Compared with normal pancreases ductal epithelial cells, miR-221-3p is up-regulated in all PCa cell lines analysed. In SW1990 cells, overexpression of miR-221-3p increased cell proliferation and inhibited apoptosis, while inhibition of miR-221-3p decreased cell growth rate and promoted apoptosis...
April 21, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28424838/improved-oncologic-outcome-with-chemoradiotherapy-followed-by-surgery-in-unresectable-intrahepatic-cholangiocarcinoma
#4
Yeona Cho, Tae Hyung Kim, Jinsil Seong
PURPOSE: To investigate the ability of chemoradiotherapy (CRT) to down-stage unresectable intrahepatic cholangiocarcinoma (IHCC) to resectable lesions, as well as the factors associated with achieving such down-staging. METHODS: The study cohort comprised 120 patients diagnosed with stage I-IVA IHCC between 2001 and 2012. Of these patients, 56 underwent surgery and 64 received CRT as their initial treatment. The rate of curative resections for patients who received CRT was assessed, and the locoregional failure-free survival (LRFFS) and overall survival (OS) rates of these patients were compared to those of patients who underwent CRT alone...
April 19, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28423684/prognostic-clinicopathologic-factors-in-carcinoma-of-unknown-primary-origin-a-study-of-106-consecutive-cases
#5
Junjeong Choi, Ji Hae Nahm, Sang Kyum Kim
A heterogeneous group of cancers for which the site of origin remains occult after detailed investigations is defined as carcinomas of unknown primary origin (CUPs). Because patients with CUP have a dismal prognosis, we have analyzed CUPs to highlight the implication of clinicopathologic factors related with patient survival. A total of 106 consecutive cases of CUP were collected. A two-step strategy of immunohistochemistry to assess CUPs according NCCN Guidelines is used to separate carcinomatous tumors and subtype carcinomas...
March 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420030/role-of-endoscopy-in-primary-sclerosing-cholangitis-european-society-of-gastrointestinal-endoscopy-esge-and-european-association-for-the-study-of-the-liver-easl-clinical-guideline
#6
Lars Aabakken, Tom H Karlsen, Jörg Albert, Marianna Arvanitakis, Olivier Chazouilleres, Jean-Marc Dumonceau, Martti Färkkilä, Peter Fickert, Gideon M Hirschfield, Andrea Laghi, Marco Marzioni, Michael Fernandez, Stephen P Pereira, Jürgen Pohl, Jan-Werner Poley, Cyriel Y Ponsioen, Christoph Schramm, Fredrik Swahn, Andrea Tringali, Cesare Hassan
1 ESGE/EASL recommend that, as the primary diagnostic modality for PSC, magnetic resonance cholangiography (MRC) should be preferred over endoscopic retrograde cholangiopancreatography (ERCP).Moderate quality evidence, strong recommendation. 2 ESGE/EASL suggest that ERCP can be considered if MRC plus liver biopsy is equivocal or contraindicated in patients with persisting clinical suspicion of PSC. The risks of ERCP have to be weighed against the potential benefit with regard to surveillance and treatment recommendations...
April 18, 2017: Endoscopy
https://www.readbyqxmd.com/read/28418859/serum-metabolomics-differentiating-pancreatic-cancer-from-new-onset-diabetes
#7
Xiangyi He, Jie Zhong, Shuwei Wang, Yufen Zhou, Lei Wang, Yongping Zhang, Yaozong Yuan
To establish a screening strategy for pancreatic cancer (PC) based on new-onset diabetic mellitus (NO-DM), serum metabolomics analysis and a search for the metabolic pathways associated with PC related DM were performed. Serum samples from patients with NO-DM (n = 30) and patients with pancreatic cancer and NO-DM were examined by liquid chromatography-mass spectrometry. Data were analyzed using principal components analysis (PCA) and orthogonal projection to latent structures (OPLS) of the most significant metabolites...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417967/nomograms-for-predicting-the-prognostic-value-of-serological-tumor-biomarkers-in-colorectal-cancer-patients-after-radical-resection
#8
Qingguo Li, Weixing Dai, Yaqi Li, Ye Xu, Xinxiang Li, Sanjun Cai
A wide range of serum tumor biomarkers, including CA19-9, CA242, CA72-4, CA50, and CA125, has been studied in association with colorectal cancer (CRC). However, few previous studies have comprehensively considered the above tumor biomarkers to assess their clinical significance in predicting prognosis. Data from Fudan University Shanghai Cancer Center (FUSCC) between January 1, 2007 and December 30, 2012 was retrospectively analyzed. Univariate and multivariate analyses were performed to assess the association between prognostic factors and survival outcomes...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28415740/development-and-validation-of-nomograms-for-predicting-survival-in-patients-with-non-metastatic-colorectal-cancer
#9
Huihong Jiang, Erjiang Tang, Dan Xu, Ying Chen, Yong Zhang, Min Tang, Yihua Xiao, Zhiyong Zhang, Xiaxing Deng, Huaguang Li, Moubin Lin
BACKGROUND: This study aimed to develop nomograms for predicting survival in patients with non-metastatic colorectal cancer (CRC). RESULTS: On multivariate analyses of the derivation set, the nomograms for OS and CSS shared common significant prognostic factors: age, first-degree relative cancer history, differentiation grade, vessels/nerves invasion, TNM stage, CEA, CA19-9 and PNI. The nomograms displayed good accuracy in predicting OS and CSS, with C-indexes of 0...
March 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415583/prognostic-value-of-circulating-endothelial-cells-in-metastatic-colorectal-cancer
#10
Nuh N Rahbari, Sebastian Schölch, Ulrich Bork, Christoph Kahlert, Martin Schneider, Mohammad Rahbari, Markus W Büchler, Jürgen Weitz, Christoph Reissfelder
BACKGROUND: There is urgent need for improved staging in patients with metastatic colorectal cancer (mCRC). In this study, we evaluated the prognostic value of circulating endothelial cells (CEC) in comparison with circulating tumor cells (CTC) in patients with mCRC amenable for potentially curative surgery. METHODS: A total of 140 patients were enrolled prospectively. CTC and CEC were measured with the CellSearch System (Veridex, NJ, USA). Cut-off values were determined using ROC analyses...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28404893/a-varying-coefficient-cox-model-for-the-effect-of-ca19-9-kinetics-on-overall-survival-in-patients-with-advanced-pancreatic-cancer
#11
Yuntao Chen, Zhenyi Shao, Wen Chen, Hua Xie, Zhenyu Wu, Guoyou Qin, Naiqing Zhao
PURPOSE: To evaluate the relationship between serum CA19-9 and overall survival in patients with advanced pancreatic cancer. METHODS: 109 advanced pancreatic cancer patients with gemcitabine based first-line chemotherapy were included. The effect of pretreatment CA19-9 level on overall survival was modeled by Cox proportional hazard regression. The effect of CA19-9 kinetics on overall survival was modeled by an extended Cox regression with a time varying coefficient and a time varying covariate...
February 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28392706/pancreatic-solitary-fibrous-tumor-in-a-toddler-managed-by-pancreaticoduodenectomy-a-case-report-and-review-of-the-literature
#12
Qingfeng Sheng, Weijue Xu, Jiangbin Liu, Baiyong Shen, Xiaxing Deng, Yibo Wu, Wei Wu, Shenghua Yu, Xueli Wang, Zhibao Lv
Solitary fibrous tumor (SFT) of the pancreas is rare, with 15 adult cases reported in the English literature. We described a 14-month-old boy who presented with obstructive jaundice. Dominantly elevated serum CA19-9 was detected. Imaging studies revealed a well-circumscribed, solid mass in the pancreatic head. A pancreaticoduodenectomy (child procedure) was performed using Shen's anastomosis technique. After resection of the tumor, liver function and serum tumor markers normalized and clinical signs receded...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28392199/short-term-clinical-efficacy-of-percutaneous-irreversible-electroporation-combined-with-allogeneic-natural-killer-cell-for-treating-metastatic-pancreatic-cancer
#13
Mao Lin, Shuzhen Liang, Xiaohua Wang, Yinqing Liang, Mingjie Zhang, Jibing Chen, Lizhi Niu, Kecheng Xu
This study was to determine how the short-term clinical efficacy of irreversible electroporation (IRE) combined with allogeneic natural killer (NK) cell therapy for treating metastatic pancreatic cancer. Between March and December 2016, we enrolled 40 patients who met the enrollment criteria and assigned them to two groups: simple IRE (IRE group, n=20) and IRE plus allogeneic NK cell therapy (IRE-NK, n=20). We evaluated immune function changes, quality of life, clinical response, and other related indicators...
April 6, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28389802/the-yonsei-criteria-as-a-clinically-detectable-parameter-for-excellent-prognosis-in-resected-left-sided-pancreatic-cancer-outcomes-of-a-propensity-score-matched-analysis
#14
Sung Hwan Lee, Ho Kyoung Hwang, Chang Moo Kang, Woo Jung Lee
BACKGROUND: This study aimed to identify that Yonsei criteria (YC) can be regarded as a preoperative clinical parameter to predict biological behavior of the left-sided pancreatic cancer. METHODS: Between June 2007 and December 2014, 135 patients who underwent minimally invasive (MIS) or open distal pancreatectomy for left-sided pancreatic cancer were enrolled in this study consecutively. Perioperative short-term and long-term oncologic outcomes were analyzed according to the YC retrospectively...
April 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28376898/identification-of-factors-that-impact-recurrence-in-patients-with-borderline-ovarian-tumors
#15
Xi Chen, Chenyan Fang, Tao Zhu, Ping Zhang, Aijun Yu, Shihua Wang
BACKGROUND: The lack of consensus around best practices for management of borderline ovarian tumors (BOT) is, in part, to the lack of available data and of clarity in interpreting relationships among various factors that impact outcomes. The objective of this study was to identify clinicopathological factors that impact prognosis of patients with borderline ovarian tumors (BOT) and to address features of this disease with the objective of providing clarity in decision making around management of BOT...
April 4, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28376157/sequential-validation-of-blood-based-protein-biomarker-candidates-for-early-stage-pancreatic-cancer
#16
Michela Capello, Leonidas E Bantis, Ghislaine Scelo, Yang Zhao, Peng Li, Dilsher S Dhillon, Nikul J Patel, Deepali L Kundnani, Hong Wang, James L Abbruzzese, Anirban Maitra, Margaret A Tempero, Randall Brand, Lenka Foretova, Eleonora Fabianova, Ivana Holcatova, Vladimir Janout, Matthew A Firpo, Sean J Mulvihill, Matthew H Katz, Paul Brennan, Ziding Feng, Ayumu Taguchi, Samir M Hanash
Background: CA19-9, which is currently in clinical use as a pancreatic ductal adenocarcinoma (PDAC) biomarker, has limited performance in detecting early-stage disease. We and others have identified protein biomarker candidates that have the potential to complement CA19-9. We have carried out sequential validations starting with 17 protein biomarker candidates to determine which markers and marker combination would improve detection of early-stage disease compared with CA19-9 alone. Methods: Candidate biomarkers were subjected to enzyme-linked immunosorbent assay based sequential validation using independent multiple sample cohorts consisting of PDAC cases (n = 187), benign pancreatic disease (n = 93), and healthy controls (n = 169)...
April 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28376080/long-term-results-and-recurrence-patterns-from-scalop-a-phase-ii-randomised-trial-of-gemcitabine-or-capecitabine-based-chemoradiation-for-locally-advanced-pancreatic-cancer
#17
C N Hurt, S Falk, T Crosby, A McDonald, R Ray, G Joseph, J Staffurth, R A Abrams, G Griffiths, T Maughan, S Mukherjee
BACKGROUND: SCALOP, a randomised, phase II trial, tested the activity and safety of gemcitabine (GEM)-based and capecitabine (CAP)-based chemoradiation (CRT) for locally advanced pancreatic cancer (LAPC). Here we present the long-term outcomes. METHODS: Eligibility: histologically proven LAPC ⩽7 cm. Following 12 weeks of induction GEMCAP chemotherapy (three cycles: GEM 1000 mg m(-2) days 1, 8, 15; CAP 830 mg m(-2) days 1-21 q28 days) patients with stable/responding disease, tumour ⩽6 cm, and WHO Performance Status 0-1 were randomised to receive one cycle GEMCAP followed by CAP (830 mg m(-2) b...
April 4, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28375170/serum-metabolomic-profiles-for-human-pancreatic-cancer-discrimination
#18
Takao Itoi, Masahiro Sugimoto, Junko Umeda, Atsushi Sofuni, Takayoshi Tsuchiya, Shujiro Tsuji, Reina Tanaka, Ryosuke Tonozuka, Mitsuyoshi Honjo, Fuminori Moriyasu, Kazuhiko Kasuya, Yuichi Nagakawa, Yuta Abe, Kimihiro Takano, Shigeyuki Kawachi, Motohide Shimazu, Tomoyoshi Soga, Masaru Tomita, Makoto Sunamura
This study evaluated the clinical use of serum metabolomics to discriminate malignant cancers including pancreatic cancer (PC) from malignant diseases, such as biliary tract cancer (BTC), intraductal papillary mucinous carcinoma (IPMC), and various benign pancreaticobiliary diseases. Capillary electrophoresismass spectrometry was used to analyze charged metabolites. We repeatedly analyzed serum samples (n = 41) of different storage durations to identify metabolites showing high quantitative reproducibility, and subsequently analyzed all samples (n = 140)...
April 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28373752/prognostic-factors-for-transarterial-chemoembolization-combined-with-sustained-oxaliplatin-based-hepatic-arterial-infusion-chemotherapy-of-colorectal-cancer-liver-metastasis
#19
Hangyu Zhang, Jianhai Guo, Song Gao, Pengjun Zhang, Hui Chen, Xiaodong Wang, Xiaoting Li, Xu Zhu
OBJECTIVE: To investigate the prognostic factors in chemorefractory colorectal cancer liver metastasis (CRCLM) patients treated by transarterial chemoembolization (TACE) and sustained hepatic arterial infusion chemotherapy (HAIC). METHODS: Between 2006 and 2015, 162 patients who underwent 763 TACE and HAIC in total were enrolled in this retrospective study, including 110 males and 52 females, with a median age of 60 (range, 26-83) years. Prognostic factors were assessed with Log-rank test, Cox univariate and multivariate analyses...
February 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28373470/clinical-significance-of-serum-p53-antibody-in-the-early-detection-and-poor-prognosis-of-gastric-cancer
#20
Masaki Kunizaki, Akiko Fukuda, Kouki Wakata, Tetsuro Tominaga, Takashi Nonaka, Takuro Miyazaki, Keitaro Matsumoto, Yorihisa Sumida, Shigekazu Hidaka, Toru Yasutake, Terumitsu Sawai, Ryuji Hamamoto, Atsushi Nanashima, Takeshi Nagayasu
BACKGROUND: The aim of this retrospective study was to evaluate the clinical relevance of serum p53 antibody (S-p53Ab) as a biomarker and to investigate whether its diagnostic value could be improved when combined with other biomarkers of gastric cancer (GC). PATIENTS AND METHODS: Serum samples were obtained preoperatively from 208 patients with histologically-confirmed GC, including 126 stage I patients (60.6%). Levels of S-p53Ab were assessed by a commercial laboratory using an anti-p53 detection kit...
April 2017: Anticancer Research
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