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https://www.readbyqxmd.com/read/29325350/-the-current-status-of-diagnosis-and-treatment-of-pancreatic-cystic-neoplasm-in-china-a-report-of-2-251-cases
#1
(no author information available yet)
Objective: To analyze the current status of diagnosis and treatment of pancreatic cystic neoplasm(PCN)in China. Methods: Clinical data of 2 251 PCN patients who underwent surgical resection from January 2006 to December 2016 in 16 institutions was retrospectively analyzed.Excel database was created which covered 132 fields of 7 fields: general information of patients, imaging findings, preoperative blood biochemical indexes, tumor markers, surgical related data, postoperative complications and pathology. Results: Of the 2 251 patients, the male to female ratio was 1...
January 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29323056/role-of-salivary-biomarkers-in-early-detection-of-oral-squamous-cell-carcinoma
#2
Nidhi Awasthi
INTRODUCTION: Oral cancer is prevalent worldwide and is a common cause of morbidity and mortality. Despite advances in treatment, the survival of patients with oral cancer has not significantly improved over the past several decades owing to late detection and treatment failures. The present study was undertaken with an objective to explore the role of salivary CYFRA 21-1, CA 19-9, lactate dehydrogenase (LDH), total proteins, and amylase as biochemical markers of oral squamous cell carcinoma (OSCC) and premalignant lesions (PML)...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29320755/downregulated-sash1-expression-indicates-poor-clinical-prognosis-in-gastric-cancer
#3
Nan Zhou, Can Liu, Xudong Wang, Qinsheng Mao, Qin Jin, Peng Li
SASH1 (SAM- and SH3-domain containing 1), a novel candidate tumor suppressor, has attracted attention due to its role in intracellular signal transduction and its tumor prognostic value in diverse cancers. Reports have demonstrated that reduced SASH1 expression correlates with tumor proliferation, invasion, and metastasis. However, the expression and prognostic significance of SASH1 in gastric cancer (GC) remain unclear. In this study, 8 paired fresh-frozen GC tissues and corresponding gastric mucosal tissues were examined by Western blot to analyze the protein expression of SASH1...
January 7, 2018: Human Pathology
https://www.readbyqxmd.com/read/29317944/is-the-glasgow-prognostic-score-applicable-to-both-early-and-advanced-stage-gastric-cancers
#4
Tomoyuki Wakahara, Nozomi Ueno, Tetsuo Maeda, Kiyonori Kanemitsu, Takuro Yoshikawa, Shinobu Tsuchida, Akihiro Toyokawa
Background: The Glasgow prognostic score (GPS) has been reported as a sensitive prognostic marker for gastric cancer. This study aimed to investigate whether the GPS is equally applicable to patients with early-stage and advanced-stage gastric cancers. Methods: Patients (n = 544) who underwent elective gastrectomy for gastric cancer between 2007 and 2015 were retrospectively studied. GPSs of 2, 1, and 0 were allocated to patients with both an elevated C-reactive protein level (> 1...
December 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/29315815/reference-intervals-of-carbohydrate-antigen-19-9-in-the-apparently-healthy-adult-population
#5
Gao-Ming Zhang, Shu-Mei Bai, Guo-Ming Zhang, Xiao-Bo Ma
BACKGROUND: To establish reference intervals of carbohydrate antigen 19-9(CA 19-9) according to the CLSI CA28-A3 guideline and to evaluate age- and gender-related variations. METHODS: Serum CA 19-9 values of 10 149 healthy subjects (from 20 years old to 60 years old) were measured from location health checkups. The relationship between CA 19-9 and age was analyzed using Spearman's approach. The reference intervals of CA19-9 were established using Q2.5 and Q97...
January 8, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29313457/the-predictive-value-and-role-of-stromal-tumor-infiltrating-lymphocytes-in-pancreatic-ductal-adenocarcinoma-pdac
#6
Tao Lianyuan, Xiu Dianrong, Yuan Chunhui, Ma Zhaolai, Jiang Bin
Recently, increasing evidence has indicated that the presence of tumor infiltrating immune cells has shown predictive significance for many solid tumors. Present study was performed to evaluate the predictive value of stromal tumor-infiltrating lymphocytes (TILs) for the presence of liver metastasis and overall survival in PDAC (pancreatic ductal adenocarcinoma) patients after complete resection and to explore the potential role of lymphocytes in PDAC. A total of 155 resectable patients with PDAC were enrolled in our study...
January 9, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29302820/microscopic-venous-invasion-in-pancreatic-cancer
#7
Mihoko Yamada, Teiichi Sugiura, Yukiyasu Okamura, Takaaki Ito, Yusuke Yamamoto, Ryo Ashida, Keiko Sasaki, Masato Nagino, Katsuhiko Uesaka
BACKGROUND: Microscopic venous invasion (MVI) and the subsequent peripheral blood circulation of cancer cells are considered to be the primary route for systemic dissemination of pancreatic cancer. METHODS: Patients who underwent pancreatectomy for invasive ductal carcinoma of the pancreas between January 2007 and December 2015 were retrospectively reviewed. The prognostic significance of MVI was analyzed. RESULTS: A total of 352 patients underwent pancreatectomy for invasive ductal carcinoma of the pancreas...
January 4, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29285292/development-of-a-novel-biomarker-model-for-predicting-preoperative-lymph-node-metastatic-extent-in-esophageal-squamous-cell-carcinoma1
#8
Zhao Ma, Xianxian Wu, Bo Xu, Hongjing Jiang, Peng Tang, Jie Yue, Mingquan Ma, Chuangui Chen, Hongdian Zhang, Zhentao Yu
The number and range of lymph node metastasis (LNM) are critical prognostic factors in esophageal squamous cell carcinoma (ESCC). Preoperative serum biomarkers are reported to be associated with LNM. However, whether these markers can precisely predict the extent of LNM is not known. The aim of this study was to evaluate the predictive value of preoperative serum SCC-Ag, Cyfra21-1, CEA, CA19-9 and CA72-4 for LNM number and range by retrospectively investigating 577 ESCC patients undergone esophagectomy from 2007-2010...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29285261/use-of-autoantibodies-against-tumor-associated-antigens-as-serum-biomarkers-for-primary-screening-of-cervical-cancer
#9
Yingji Jin, Seung Cheol Kim, Hyoung Jin Kim, Woong Ju, Yun Hwan Kim, Hong-Jin Kim
Serum autoantibodies against tumor-associated antigens (TAAs) have received much attention as potential biomarkers for early detection of cancers, since they can be detected in the early stages of cancers. Autoantibodies against Cancer Antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA), Cancer Antigen 19-9 (CA19-9), c-Myc, p53, heat shock protein (Hsp)27 and Hsp70 have been suggested as potential markers for detecting several types of cancer. In the present study, the seven types of antibody listed above were evaluated for detecting cervical lesions...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29282264/comparing-the-diagnostic-accuracy-of-five-common-tumour-biomarkers-and-ca19-9-for-pancreatic-cancer-a-protocol-for-a-network-meta-analysis-of-diagnostic-test-accuracy
#10
Long Ge, Bei Pan, Fujian Song, Jichun Ma, Dena Zeraatkar, Jianguo Zhou, Jinhui Tian
INTRODUCTION: Surgical resection is the only curative treatment for patients with resectable pancreatic cancer. Unfortunately, 80%-85% of patients present with locally advanced or metastatic unresectable pancreatic cancer at the time of diagnosis. Detection of pancreatic cancer at early stages remains a great challenge due to lack of accurate detection tests. Recommendations in existing clinical practice guidelines on early diagnosis of pancreatic cancer are inconsistent and based on limited evidence...
December 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/29277792/neoadjuvant-chemotherapy-with-gemcitabine-plus-nab-paclitaxel-reduces-the-number-of-cancer-associated-fibroblasts-through-depletion-of-pancreatic-stroma
#11
Tomoharu Miyashita, Hidehiro Tajima, Isamu Makino, Mitsuyoshi Okazaki, Takahisa Yamaguchi, Yoshinao Ohbatake, Sinichi Nakanuma, Hironori Hayashi, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Koji Kishimoto, John W Harmon, Tetsuo Ohta
BACKGROUND: In this study, the effects of neoadjuvant chemotherapy (NAC) on cancer-associated fibroblasts (CAFs) in pancreatic cancer stroma were investigated. MATERIALS AND METHODS: Density of α-smooth muscle actin (αSMA)-positive fibroblasts in resected surgical specimens from untreated patients, patients receiving conventional gemcitabine plus S-1 (GS), and patients receiving gemcitabine plus nab-paclitaxel (GnP) was determined by hybrid cell counting. 18F-Fluorodeoxyglucose positron-emission tomography (FDG-PET) scans and carbohydrate antigen 19-9 (CA19-9) concentrations were used to assess tumor activity before and after chemotherapy in the GnP group...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29274841/preoperative-risk-score-and-prediction-of-long-term-outcomes-after-hepatectomy-for-intrahepatic-cholangiocarcinoma
#12
Kazunari Sasaki, Georgios A Margonis, Nikolaos Andreatos, Fabio Bagante, Matthew Weiss, Carlotta Barbon, Irinel Popescu, Hugo P Marques, Luca Aldrighetti, Shishir K Maithel, Carlo Pulitano, Todd W Bauer, Feng Shen, George A Poultsides, Oliver Soubrane, Guillaume Martel, B Groot Koerkamp, Alfredo Guglielmi, Endo Itaru, Federico N Aucejo, Timothy M Pawlik
BACKGROUND: Accurate prediction of prognosis for patients with intrahepatic cholangiocarcinoma(ICC) remains a challenge. We sought to define a preoperative risk tool to predict long-term survival following resection of ICC. METHODS: Patients who underwent hepatectomy for ICC at one of 16 major hepatobilliary centers between 1990-2015 were identified. Clinico-pathological data were analyzed and a prognostic model was developed based on the regression beta-coefficients on data in training set...
December 21, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29272982/the-significance-of-serum-igg4-and-ca19-9-autoantibodies-in-diagnosis-and-differential-diagnosis-of-igg4-related-sclerosing-cholangitis
#13
Liming Tan, Xiaolin Guan, Tingting Zeng, Sifan Wu, Wei Zheng, Huiying Fu, Tingting Long, Qiaohua Wang, Yimei Meng, Yongjian Tian, Jianlin Yu, Juanjuan Chen, Hua Li, Liping Cao
OBJECTIVE: To investigate the value of serum levels of IgG4 and CA19-9, and autoantibodies in the diagnosis of IgG4-related sclerosing cholangitis (IgG4-SC). METHODS: We detected the serum IgG4 and CA19-9 of 45 IgG4-SC patients, 173 non-IgG4-SC patients and 48 healthy controls by immunoassay and chemiluminescence, respectively, with antinuclear antibody (ANA), anti-neutrophil antibody (ANCA), anti-smooth muscle antibody (SMA) and anti-mitochondrial antibody (AMA) level detected by indirect immunofluorescence...
December 22, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29250161/detection-of-k-ras-gene-mutations-in-feces-by-magnetic-nanoprobe-in-patients-with-pancreatic-cancer-a-preliminary-study
#14
Xiaoguang Wang, Jingshuai Wang, Fei Chen, Zhengxiang Zhong, Lifeng Qi
The present study aimed to investigate the feasibility and effectiveness of detecting K-ras mutation by using magnetic nanoparticles in fecal samples of patients with pancreatic cancer at different stages. The novel methodology of K-ras mutation detection was compared to the existing methodology of cancer antigen (CA)19-9 examination. Patients with pancreatic cancer (n=88), pancreatic benign diseases who displayed chronic pancreatitis (n=35), pancreatic mucinous cyst neoplasms (n=10) and pancreatic serous cyst (n=9) admitted to the Department of Surgery, Jiaxing Second Hospital were enrolled in the present study...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29232830/evidence-of-altered-glycosylation-of-serum-proteins-prior-to-pancreatic-cancer-diagnosis
#15
Shibu Krishnan, Harry J Whitwell, Joy Cuenco, Aleksandra Gentry-Maharaj, Usha Menon, Stephen P Pereira, Marco Gaspari, John F Timms
Biomarkers for the early detection of pancreatic cancer are urgently needed. The aim of this pilot study was to evaluate changes in serum N-glycoproteins and their glycosylation status prior to clinical presentation of pancreatic cancer that may be potential biomarkers. Prediagnosis serum samples pooled according to five time-to-diagnosis groups and a non-cancer control pool were digested with trypsin, labelled with mass tags, and subjected to titanium dioxide capture, deglycosylation, and 2D-LC-MS/MS profiling...
December 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29228650/ultrasensitive-plasma-ctdna-kras-assay-for-detection-prognosis-and-assessment-of-therapeutic-response-in-patients-with-unresectable-pancreatic-ductal-adenocarcinoma
#16
Inna Chen, Victoria M Raymond, Jennifer A Geis, Eric A Collisson, Benny V Jensen, Kirstine L Hermann, Mark G Erlander, Margaret Tempero, Julia S Johansen
Precision oncology requires sensitive and specific clinical biomarkers. Carbohydrate Antigen 19-9 (CA19-9) is widely used in pancreatic ductal adenocarcinoma (PDA) but lacks sensitivity and specificity. Nearly all PDAs harbor somatic KRAS mutations, nominating circulating tumor DNA (ctDNA) KRAS as an alternative disease biomarker, however, variable clinical performance has limited its clinical utility. We applied an ultrasensitive, PCR mutation enrichment, next generation sequencing ctDNA KRAS assay in a large cohort of patients with unresectable PDA (N = 189) recruited to the BIOPAC study between 2008-2015...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29226859/identification-of-mannose-receptor-and-cd163-as-novel-biomarkers-for-colorectal-cancer
#17
Dongbing Ding, Yao Yao, Changming Yang, Songbai Zhang
The aim of present study was to investigate the clinical significances of mannose receptor (MR) and CD163 in colorectal cancer (CRC). Enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry (IHC) were utilized for this analysis. Preoperative serum MR and CD163 levels ranged from 0.153 to 0.804 μg/ml (median = 0.359 μg/ml) and from 0.319 to 1.314 μg/ml (median = 0.685 μg/ml) in CRC patients respectively. Strikingly, preoperative serum levels of MR and CD163 were significantly increased in CRC patients than in healthy individuals (P< 0...
November 30, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29217428/clinical-significance-of-galnacylated-glycans-in-cholangiocarcinoma-values-for-diagnosis-and-prognosis
#18
Waraporn Saentaweesuk, Atit Silsirivanit, Kulthida Vaeteewoottacharn, Kanlayanee Sawanyawisuth, Chawalit Pairojkul, Ubon Cha'on, Somsiri Indramanee, Somchai Pinlaor, Thidarut Boonmars, Norie Araki, Chaisiri Wongkham
Cancer cells exhibited the aberrant cancer-associated glycans that are potential biomarkers for diagnosis and monitoring of the cancer. In this study, Sophora japonica agglutinin (SJA) was used to detect SJA-specific N-acetylgalactosamine-associated glycans (SNAG) in liver tissues and sera from cholangiocarcinoma (CCA) patients. Whether SNAG could be the diagnostic and prognostic markers for CCA was evaluated. SJA-histochemistry revealed that SNAG was undetec2 in normal bile ducts but was highly expressed in hyperplastic/dysplastic bile ducts and CCA...
December 4, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29212171/clinical-outcomes-and-prognostic-factors-of-stereotactic-body-radiation-therapy-for-intrahepatic-cholangiocarcinoma
#19
Ze-Tian Shen, Han Zhou, Ao-Mei Li, Bing Li, Jun-Shu Shen, Xi-Xu Zhu
Stereotactic body radiation therapy (SBRT) has been an emerging non-invasive treatment modality for patients with intrahepatic cholangiocarcinoma (ICC) when surgical treatment cannot be applied. The CyberKnife® is a SBRT system that allows for real-time tracking of the tumor. The purpose of this study was to evaluate the clinical outcomes and prognostic factors for ICC patients receiving this treatment. Twenty-eight patients with ICC were enrolled in the present study. The median prescription dose was 45 Gy (range, 36-54 Gy), fractionated 3 to 5 times with a 70% to 92% isodose line...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29208940/cea-but-not-ca19-9-is-an-independent-prognostic-factor-in-patients-undergoing-resection-of-cholangiocarcinoma
#20
Sven H Loosen, Christoph Roderburg, Katja L Kauertz, Alexander Koch, Mihael Vucur, Anne T Schneider, Marcel Binnebösel, Tom F Ulmer, Georg Lurje, Wenzel Schoening, Frank Tacke, Christian Trautwein, Thomas Longerich, Cornelis H Dejong, Ulf P Neumann, Tom Luedde
Cholangiocarcinoma (CCA) represents a rare form of primary liver cancer with increasing incidence but dismal prognosis. Surgical treatment has remained the only potentially curative treatment option, but it remains unclear which patients benefit most from liver surgery, highlighting the need for new preoperative stratification strategies. In clinical routine, CA19-9 represents the most widely used tumor marker in CCA patients. However, data on the prognostic value of CA19-9 in CCA patients are limited and often inconclusive, mostly due to small cohort sizes...
December 5, 2017: Scientific Reports
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