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Ca19-9

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https://www.readbyqxmd.com/read/28212545/snora74b-gene-silencing-inhibits-gallbladder-cancer-cells-by-inducing-phlpp-and-suppressing-akt-mtor-signaling
#1
Yiyu Qin, Li Meng, Yang Fu, Zhiwei Quan, Mingzhe Ma, Mingzhe Weng, Zhengdong Zhang, Cuixiang Gao, Xinghua Shi, Koulan Han
Small nucleolar RNAs (snoRNAs) have been implicated in the development of many cancers. We therefore examined the differential expression of snoRNAs between gallbladder cancer (GBC) tissues and matched adjacent non-tumor tissues using expression microarray analysis with confirmation by quantitative real-time PCR (qRT-PCR). Western blot analysis showed that SNORA74B levels were higher in GBC than non-tumor tissues. SNORA74B expression was positively associated with local invasion, advanced TNM stage, CA19-9 level, and Ki67 expression in patients with GBC, while it was negatively associated with expression of PHLPP, an endogenous Akt inhibitor...
February 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28197876/enhancing-pancreatic-mass-with-normal-serum-ca19-9-key-mdct-features-to-characterize-pancreatic-neuroendocrine-tumours-from-its-mimics
#2
Liang Zhu, Hua-Dan Xue, Wei Liu, Xuan Wang, Xin Sui, Qin Wang, Daming Zhang, Ping Li, Zheng-Yu Jin
OBJECTIVES: To determine key MDCT features for characterizing pancreatic neuroendocrine tumours (PNET) from their mimics, which manifest as enhancing pancreatic mass with normal serum CA19-9 level. METHODS: This retrospective study had institutional review board approval and informed consent was waived. Preoperative multiphase MDCT of 74 patients with enhancing pancreatic masses and normal serum CA19-9 levels were included. Surgical pathologies were PNET (n = 42), microcystic serous cystadenomas (m-SCN, n = 12) and solid pseudopapillary epithelial neoplasms (SPEN, n = 20)...
February 15, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28194091/establishment-and-characterization-of-a-novel-highly-aggressive-gallbladder-cancer-cell-line-tj-gbc2
#3
Zhong-Yan Liu, Guo-Li Xu, Hui-Hong Tao, Yao-Qin Yang, Yue-Zu Fan
BACKGROUND: Human gallbladder cancer (GBC) is an aggressive malignant neoplasm with a poor prognosis. The development of ideal tools for example tumor cell lines for investigating biological behavior, metastatic mechanism and potential treatment in GBCs is essential. In present study, we established and characterized a GBC cell line derived from primary tumor. METHODS: Primary culture method was used to establish this cell line from a primary GBC. Light and electron microscopes, flow cytometry, chromosome analysis, heterotransplantation and immunohistochemistry were used to characterize the epidemic tumor characteristics and phenotypes of this cell line...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28191976/preloading-with-unlabeled-ca19-9-targeted-human-monoclonal-antibody-leads-to-improved-pet-imaging-with-89zr%C3%A2-5b1
#4
Jacob Lee Houghton, Dalya Abdel-Atti, Wolfgang W Scholz, Jason S Lewis
CA19.9 is one of the most commonly occurring and highest density antigens in >90% of pancreatic cancers, making it an excellent target for monoclonal antibody (mAb)-based imaging and therapy applications. Preloading of unlabeled antibodies to enhance targeting of a radiolabeled mAb has been previously described both for imaging and radioimmunotherapy studies for other targets. We investigated the effect of preloading with the unmodified anti-CA19.9 antibody 5B1 on the uptake and contrast of the PET tracer 89Zr-5B1 in subcutaneous and orthotopic murine models of pancreatic cancer utilizing Capan-2 xenografts, known to both expresses CA19...
February 13, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28180987/preoperative-high-maximum-standardized-uptake-value-in-association-with-glucose-transporter-1-predicts-poor-prognosis-in-pancreatic-cancer
#5
Akira Chikamoto, Risa Inoue, Yoshiaki Komohara, Kentaro Sakamaki, Daisuke Hashimoto, Shinya Shiraishi, Hiroshi Takamori, Yo-Ichi Yamashita, Naoya Yoshida, Takeharu Yamanaka, Yasuyuki Yamashita, Hideo Baba
BACKGROUND: The diagnosis of malignant diseases worldwide has been determined using (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET). Glucose transporter type 1 (Glut-1) is a key protein associated with the accumulation of FDG in cancer cells. This study evaluated the relationship between Glut-1 expression and FDG accumulation to determine the usefulness of FDG-PET for prediction of long-term outcomes of pancreatic cancer. METHODS: The expression of Glut-1 was immunohistochemically examined in 138 surgically resected pancreatic cancer specimens...
February 8, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28179344/carbohydrate-antigen-19-9-predicts-synchronous-peritoneal-carcinomatosis-in-patients-with-colorectal-cancer
#6
Manabu Kaneko, Soichiro Ishihara, Koji Murono, Kazuhito Sasaki, Kensuke Otani, Koji Yasuda, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Hiroaki Nozawa, Hiroshi Nakayama, Toshiyuki Watanabe, Shin Sasaki, Toshiaki Watanabe
BACKGROUND: Colorectal cancer (CRC) with peritoneal carcinomatosis (PC) has the worst prognosis among all types of metastases, but is difficult to diagnose. This study investigated whether preoperative serum carbohydrate antigen (CA) 19-9 level can predict synchronous PC in patients with primary CRC. PATIENTS AND METHODS: The cases of 395 CRC patients who underwent primary lesion resection were retrospectively reviewed. Risk factors were evaluated by uni- and multivariate analyses from clinicopathological data...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28179327/postoperative-radiotherapy-for-pancreatic-cancer-with-microscopically-positive-resection-margin
#7
Sunmin Park, Song Cheol Kim, Seung-Mo Hong, Young-Joo Lee, Kwang-Min Park, Dae Wook Hwang, Jae Hoon Lee, Ki-Byung Song, Baek-Yeol Ryoo, Heung-Moon Jang, Kyu-Pyo Kim, Changhoon Yu, Eun Kyung Choi, Seung DO Ahn, Sang-Wook Lee, Sang Min Yoon, Jin-Hong Park, Jong Hoon Kim
AIM: To analyze the outcomes in pancreatic cancer (PC) cases with a microscopically-positive resection margin (R1 resection) treated with postoperative radiotherapy (PORT). PATIENTS AND METHODS: We retrospectively analyzed the outcomes in 62 patients who received PORT for PC with R1 resection between 2001 and 2012. All patients received three-dimensional conformal radiotherapy. Concurrent chemotherapy was administered to 58 patients. RESULTS: The median follow-up was 20...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28174387/-a-case-of-heterochronic-ovarian-metastasis-from-sigmoid-colon-cancer-after-sigmoidectomy-treated-with-capeox-that-included-bevacizumab
#8
Reiko Ono, Norihito Ise, Hiroshi Yoshioka, Wataru Iwasaki, Kimihiko Sato, Makoto Niwa
The patient was a 41-year-old woman. When she was 39 years old, she had undergone laparoscopic high anterior resection for sigmoid colon cancer without adjuvant chemotherapy. Histologically, the surgical specimen was type 2, tub2, pT4a (SE), pN0, int, INF b, ly1, v1, and pStage II. Nine months after the operation, she suffered from abdominal fullness. Laborato- rydata showed elevation of tumor markers: the CEA level was 6.48 ng/mL, the CA19-9 level was 89.70 U/mL, and the CA125 level was 662 U/mL. Computed tomographyrevealed bilateral ovarian tumors and lung and peritoneal nodules with massive ascites...
January 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28169208/evaluation-of-prognostic-factors-and-implication-of-lymph-node-dissection-in-intrahepatic-cholangiocarcinoma-10-year-experience-at-a-tertiary-referral-center
#9
Miao-Erh Chang, Hao-Jan Lei, Ming-Huang Chen, Yi-Chen Yeh, Chung-Pin Li, Yi-Ping Hung, Cheng-Yuan Hsia, Chieu-An Liu, Gar-Yang Chau, Yee Chao
BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver malignancy, and surgical resection remains the only potentially curative treatment. However, the existing literature indicates that those prognostic factors associated with outcome after surgery remain poorly defined. METHODS: Data were retrospectively collected from 103 patients with ICC who underwent surgical resection between 2005 and 2014. The patients were divided into two groups: one with (D1) and one without (D0) lymph node dissection of hepatic hilum according to the surgery performed...
February 3, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28161529/the-charlson-age-comorbidity-index-predicts-prognosis-in-patients-with-resected-pancreatic-cancer
#10
Tomonari Asano, Suguru Yamada, Tsutomu Fujii, Norimitsu Yabusaki, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera
BACKGROUND: The Charlson age comorbidity index (CACI) is a useful measure of comorbidity to standardize the evaluation of surgical patients and has been reported to predict postoperative mortality in various cancers. METHOD: A total of 379 patients who underwent R0/R1 resection for pancreatic cancer between 2003 and 2014 were enrolled in this study. According to the CACI, the age-adjusted comorbidity index was calculated by weighting individual comorbidities; CACI<4 was considered the low-CACI group, whereas CACI≥4 was considered the high-CACI group...
February 2, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28154778/surgical-treatment-of-intrahepatic-cholangiocarcinoma-a-retrospective-study-of-104-cases
#11
Xiao-Dong Xun, Qiang Li
OBJECTIVE: To explore the clinicopathological features, surgical treatment techniques, and prognostic risk factors of intrahepatic cholangiocarcinoma (ICC). METHODS: A total of 104 ICC cases were collected from January 2008 to December 2013 at Tianjin Medical University Cancer Institute and Hospital and divided into the hepatic hilum lymphadenectomy (HLL, 21 cases), extended hepatic hilum lymphadenectomy (EHLL, 12 cases), and non-lymphadenectomy (NL, 71 cases) groups...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28150073/first-in-human-phase-i-study-of-sor-c13-a-trpv6-calcium-channel-inhibitor-in-patients-with-advanced-solid-tumors
#12
S Fu, H Hirte, S Welch, T T Ilenchuk, T Lutes, C Rice, N Fields, A Nemet, D Dugourd, S Piha-Paul, V Subbiah, L Liu, J Gong, D Hong, J M Stewart
Introduction This was an open-label, dose escalation (3 + 3 design), Phase I study of SOR-C13 in patients with advanced tumors of epithelial origin. Primary objectives were to assess safety/tolerability and pharmacokinetics. Secondary goals were to assess pharmacodynamics and efficacy of SOR-C13. Methods SOR-C13 was administered IV QD on days 1-3 and 8-10 of a 21-day cycle. Doses were 2.75 and 5.5 mg/kg (20-min infusion) and 1.375, 2.75, 4.13 and 6.2 mg/kg (90-min infusion). Toxicity was assessed by National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4...
February 1, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28133696/the-serum-levels-of-tumor-marker-ca19-9-cea-ca72-4-and-nse-in-type-2-diabetes-without-malignancy-and-the-relations-to-the-metabolic-control
#13
Xiaojing Shang, Chunqing Song, Xiaoming Du, Hailin Shao, Donghong Xu, Xiaolai Wang
To investigate whether there is a difference in carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA), carbohydrate antigen 72-4 (CA72-4), and neuron-specific enolase (NSE) between diabetic and non-diabetic patients.  Methods: A retrospective analysis was performed in 268 type 2 diabetic patients and 95 non-diabetic ones, and their serum levels of CA19-9, CEA, CA72-4, and NSE were compared in our endocrine ward at the Tianjin Fourth Central Hospital, Tianjin, Chinaduring the period from January to June 2015...
February 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28133337/-a-case-of-peritoneal-dissemination-of-hilar-cholangiocarcinoma-presenting-with-hematuria-six-years-after-radical-surgery
#14
Noriaki Koizumi, Yuen Nakase, Hiroki Kobayashi, Tsuyoshi Takagi, Kanehisa Fukumoto
A 76-year-old man underwent radical surgery for Stage IV a hilar cholangiocarcinoma in July 2009, and had been followed at an outpatient clinic. Although no apparent recurrent lesion was detected by PET/CT examination, an elevated CA19-9 level was found in January 2014. He was then started on the oral anticancer drug S-1. However, his CA19-9 level increased gradually. The patient presented to a urological department with a complaint of macrohematuria in May 2015. Detailed examination revealed a mass lesion at the top of the urinary bladder, which was suspected to be peritoneal dissemination of the known hilar cholangiocarcinoma invading the urinary bladder wall...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133316/-regrowth-of-isolated-local-residual-tumor-effectively-treated-with-chemoradiotherapy-more-than-five-years-after-a-resection-for-pancreatic-cancer-with-an-involvement-of-the-portal-vein
#15
Tomonori Matsumura, Eishi Totsuka, Kenta Kitamura, Keigo Okada, Satoshi Inose, Motoi Koyama, Naokazu Nakamura, Shigeru Masamura, Kazuhiro Karikomi, Tatsushi Suwa
A 55-year-old man who presented with abdominal pain was diagnosed with pancreatic head cancer involving the portal vein. He underwent pylorus-preserving pancreaticoduodenectomy without a resection of the portalvein, resulting in a macroscopic residualtumor, because radicalresection was impossible owing to the severe localinvasion. Postoperative chemotherapy( GEM plus S-1)was administered. The tumor size decreased and CA19-9 values normalized. Five years after the resection, chemotherapy was stopped. The regrowth of an isolated local residual tumor without a distant metastasis was diagnosed 65 months after the resection...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133284/-an-autopsy-case-of-an-elderly-patient-with-signet-ring-cell-carcinoma-of-the-breast-derived-from-lobular-carcinoma
#16
Gen Tsujio, Naoki Aomatsu, Seika Tei, Yoshihito Yamakoshi, En Wang, Daisuke Nagashima, Toshiki Hirakawa, Takehiko Iwauchi, Takafumi Nishii, Junya Morimoto, Kazunori Nakazawa, Yasutake Uchima, Hiroshi Harada, Kiyoshi Kawano, Kazuhiro Takeuchi
A 90-year-old woman was referred to our hospital because of abdominal distension and pretibial edema. No tumors were palpable in either breast. Her abdomen was distended and palpitation was noticed. Laboratory examination revealed hypercalcemia and elevated levels of tumor markers(PIVKA- II , CEA, CA19-9, SCC). Contrast-enhanced computed tomography(CT) showed pleural effusion and ascites, an approximately 17-mm high-contrast mass in the D area of the left breast, and osteolysis of the dorsal lumber spine. We initiated treatment for pleural effusion, ascites, and hypercalcemia...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133201/-long-term-survival-in-response-to-multimodality-therapy-in-a-patient-with-invasive-pancreatic-cancer-with-cyst-formation
#17
Hironobu Makino, Hisashi Kametaka, Tadaomi Fukada, Kazuhiro Seike, Akio Hasegawa, Masaru Isozaki
The patient was a 61-year-old man. Computed tomography(CT)in April 2007 revealed a pancreatic cyst in the tail of the pancreas. Rapid enlargement was noted in November 2007, and the patient was referred to the surgery department. CT showed a cystic lesion containing a nodular shadow in the pancreatic tail. Tumor marker measurements yielded normal carcinoembryonic antigen(CEA)and carbohydrate antigen 19-9(CA19-9)levels, but the duke pancreatic monoclonal antigen type 2(DUPAN-2)level was elevated. A diagnosis of mucinous cystic neoplasm(MCN)of the pancreas was made in December 2007, and distal pancreatectomy and partial colectomy were performed...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133190/-a-case-of-trousseau-s-syndrome-caused-by-ca19-9-producing-gastric-cancer
#18
Tomoyuki Nagata, Kei Nakamura, Akira Sougawa, Satoshi Mochizuki, Yuen Nakase, Shozo Kitai, Seishirou Inaba
Trousseau's syndrome is a coagulation disorder occurring in cancer patients. In the present study, we report our experience regarding the pathophysiology and treatment strategies of this syndrome that is caused by CA19-9-producing gastric cancer during long term chemotherapy. A 60s male presented to our clinic; he was found to have a high level of CA19-9. An advanced gastric cancer was identified by gastric scope. A totalgastrectomy was performed. Severalcourses of chemotherapy were administered, and the level of CA19-9 was measured over a long period...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133173/-remission-of-advanced-gastric-cancer-with-concurrent-portal-vein-tumor-thrombosis-via-chemotherapy-a-case-report
#19
Seiko Miura, Nobuhiko Ueda, Hideto Fujita, Shinichi Kinami, Takeo Kosaka, Hiroshi Funaki, Noriaki Sakata, Ryuhei Nishino, Wataru Koda
The following is a case report of moderately differentiated tubular adenocarcinoma of the stomach with widespread thrombosis of the portal vein, for which chemotherapy proved effective. A 75-year-old man presented to the clinic with a new onset ofmalaise. The patient had anemia, elevation ofliver and biliary enzymes, and significantly elevated CA19-9 levels at 43,581 U/mL and CEA levels at 2,560 ng/mL. An upper endoscopy revealed a mass lesion extending from the fundus to the pylorus as well as to the duodenum along the smaller curvature of the stomach...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133094/-experience-with-gemcitabine-plus-nab-paclitaxel-therapy-for-advanced-metastatic-pancreatic-cancer-in-our-hospital
#20
Shigeta Hagino, Akira Nakayama, Koya Sakamoto
A 71-year-old-man was referred to our hospital because of jaundice of the skin. On biochemical examination of blood, we identified an elevation in the levels of AST and ALT, the serum level of biliary enzymes, and the serum levels of tumor markers. We found pancreatic head cancer with invasion to the main blood vessels and duodenum, with liver metastases, on abdominal CT. We made a diagnosis of unresectable advanced pancreatic head cancer with distant metastasis, and we initiated gemcitabine plus nab-paclitaxel therapy as first-line chemotherapy...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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