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https://www.readbyqxmd.com/read/27923977/absence-of-renal-enlargement-in-fructose-fed-proximal-tubule-select-insulin-receptor-ir-insulin-like-growth-factor-receptor-igf1r-double-knockout-mice
#1
Lijun Li, Marcus Byrd, Kwame Doh, Patrice D Dixon, Hwal Lee, Swasti Tiwari, Carolyn M Ecelbarger
The major site of fructose metabolism in the kidney is the proximal tubule (PT). To test whether insulin and/or IGF1 signaling in the PT is involved in renal structural/functional responses to dietary fructose, we bred mice with dual knockout (KO) of the insulin receptor (IR) and the IGF1 receptor (IGF1R) in PT by Cre-lox recombination, using a γ-glutamyl transferase promoter. KO mice had slightly (~10%) reduced body and kidney weights, as well as, a reduction in mean protein-to-DNA ratio in kidney cortex suggesting smaller cell size...
December 2016: Physiological Reports
https://www.readbyqxmd.com/read/27917754/managing-heart-failure-in-long-term-care-recommendations-from-an-interprofessional-stakeholder-consultation
#2
George A Heckman, Veronique M Boscart, Teresa D'Elia, Mary Lou Kelley, Sharon Kaasalainen, Carrie A McAiney, Mary-Lou van der Horst, Robert S McKelvie
Heart failure (HF) affects up to 20 per cent of residents in long-term care (LTC) and is associated with substantial morbidity, mortality, and health service utilization. Our study objective was to formulate recommendations on implementing HF care processes in LTC. A three-phase and iterative stakeholder consultation process, guided by expert panel input, was employed to develop recommendations on implementing care processes for HF in LTC. This article presents the results of the third phase, which consisted of a series of interdisciplinary workshops...
December 2016: Canadian Journal on Aging, la Revue Canadienne du Vieillissement
https://www.readbyqxmd.com/read/27916218/fenofibrate-attenuates-malignant-hypertension-by-suppression-of-the-renin-angiotensin-system-a-study-in-cyp1a1-ren-2-transgenic-rats
#3
Šárka Jíchová, Šárka Doleželová, Libor Kopkan, Elzbieta Kompanowska-Jezierska, Janusz Sadowski, Luděk Červenka
BACKGROUND: Malignant hypertension is a life-threatening condition, and its pathophysiology is still poorly understood. The present study was designed to evaluate the role of interaction of the renin-angiotensin system with 20-hydroxyeicosatetraenoic acid (20-HETE), a product of cytochrome P450 (CYP)-dependent ω-hydroxylase pathway, in the pathophysiology of angiotensin II (ANG II)-dependent malignant hypertension in Cyp1a1-Ren-2 transgenic rats. METHODS: Malignant hypertension was induced by 12 days׳ dietary administration of 0...
December 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27912750/fermented-barley-and-soybean-bs-mixture-enhances-intestinal-barrier-function-in-dextran-sulfate-sodium-dss-induced-colitis-mouse-model
#4
Jong Kyu Woo, Seungho Choi, Ju-Hee Kang, Dae Eung Kim, Byung-Serk Hurh, Jong-Eun Jeon, Sun Yeou Kim, Seung Hyun Oh
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by chronic or relapsing immune system activation and inflammation within the gastrointestinal tract. The lack of safety and efficacy of standard therapies, the use of food supplements for managing IBD is increasing, and many studies have reported that various food supplements provide many beneficial effects for the IBD. METHODS: This study aimed to evaluate the anti-colitis effects of dietary supplementation with a fermented barley and soybean mixture (BS) on intestinal inflammation using a murine model of IBD...
December 3, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27910204/recommended-standards-for-assessing-blood-pressure-in-human-research-where-blood-pressure-or-hypertension-is-a-major-focus
#5
(no author information available yet)
Although inaccurate, nonreproducible blood pressure values can result from nonstandardized assessments, recommended approaches to standardize blood pressure measurement are often not followed in research studies. An expert consensus of national and international health and scientific organizations developed recommended minimum standards for assessing blood pressure in research subjects where: (1) blood pressure or hypertension is a major end point, or (2) blood pressure is likely a major mediator of the research outcome...
December 2, 2016: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/27909897/nha2-is-expressed-in-distal-nephron-and-regulated-by-dietary-sodium
#6
Kalyan C Kondapalli, R Todd Alexander, Jennifer L Pluznick, Rajini Rao
Increased renal reabsorption of sodium is a significant risk factor in hypertension. An established clinical marker for essential hypertension is elevated sodium lithium countertransport (SLC) activity. NHA2 is a newly identified Na(+)(Li(+))/H(+) antiporter with potential genetic links to hypertension, which has been shown to mediate SLC activity and H(+)-coupled Na(+)(Li(+)) efflux in kidney-derived MDCK cells. To evaluate a putative role in sodium homeostasis, we determined the effect of dietary salt on NHA2...
December 1, 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27909558/nutritional-quality-of-lunches-consumed-by-korean-workers-comparison-between-institutional-and-commercial-lunches
#7
Won Gyoung Kim, Injoo Choi, Jihyun Yoon
BACKGROUND/OBJECTIVES: The nutritional quality of lunches is an important factor related to workers' health. This study examined the nutritional quality of Korean workers' lunches with a focus on comparing institutional and commercial lunches. SUBJECTS/METHODS: The data from a 1-day, 24-hour dietary recall from the 5(th) Korea National Health and Nutrition Examination Survey (2010-2012) were analyzed. A total of 2,192 subjects aged 19 to 64 years, who had consumed lunches served by institutional or commercial food service vendors, were included for analysis...
December 2016: Nutrition Research and Practice
https://www.readbyqxmd.com/read/27908548/dietary-sodium-and-potassium-intakes-data-from-urban-and-rural-areas
#8
Carmelle Mizéhoun-Adissoda, Dismand Houinato, Corine Houehanou, Thierry Chianea, François Dalmay, André Bigot, Victor Aboyans, Pierre-Marie Preux, Pascal Bovet, Jean-Claude Desport
OBJECTIVES: Hypertension is highly prevalent in West African populations, but little data is available on salt and potassium intake in these populations. We assumed in this study that sodium and potassium intake might be high and low, respectively, in the Beninese population in view of the emerging nutritional transition. The aim of this study was to estimate dietary sodium and potassium intakes based on 24-h urine collections. METHODS: We selected 420 individuals (ages 25-64 y), representative of the population, from urban and rural areas in Benin...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27908484/maintenance-fluid-therapy-isotonic-versus-hypotonic-solutions
#9
REVIEW
Bernie Hansen, Alessio Vigani
The goal of maintenance fluid therapy in small animals is to replace normal ongoing losses of water and salts when oral intake is withheld. Hospitalized dogs and cats may have multiple stimuli for antidiuretic hormone release that disrupt normal osmoregulation and predispose to water retention. Severe illness promotes retention of both sodium and water as edema. Commercially available fluids have electrolyte concentrations that are very different from dietary maintenance requirements, and potential consequences include development of hypoosmolality, edema, or both when excesses of water or sodium are administered...
November 28, 2016: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/27905933/salt-intakes-in-sub-saharan-africa-a-systematic-review-and-meta-regression
#10
Oyinlola Oyebode, Samuel Oti, Yen-Fu Chen, Richard J Lilford
BACKGROUND: High sodium intake increases the risk of hypertension and cardiovascular diseases. For this reason the World Health Organization recommends a maximum intake of 2 g per day and a 30 % reduction in population sodium intake by 2025. However, in global reviews, data on sodium intake in sub-Saharan Africa have been limited. METHODS: A systematic review was conducted to identify studies reporting sodium intake in sub-Saharan African populations. Meta-regression analyses were used to test the effect of year of data collection and method of data collection (urinary/dietary), as well as any association between sex, urban/rural status or a country's economic development, and population sodium intake...
January 11, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27903829/long-term-adherence-to-low-sodium-diet-in-patients-with-heart-failure
#11
Misook L Chung, Linda Park, Susan K Frazier, Terry A Lennie
Although following a low-sodium diet (LSD) for heart failure (HF) has been recommended for decades, little is known about factors related to long-term patient adherence. The purposes of this study were to (a) compare sodium intake and factors affecting adherence in a long-term adherent group and in a non-adherent group and (b) examine predictors of membership in the long-term adherent group. Patients with HF (N = 74) collected 24-hr urine samples and completed the Dietary Sodium Restriction Questionnaire and the Patient Health Questionnaire-9...
November 30, 2016: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/27903514/do-high-salt-microenvironments-drive-hypertensive-inflammation
#12
Jason D Foss, Annet Kirabo, David G Harrison
Hypertension is a global epidemic affecting over one billion people worldwide. Despite this, the etiology of most cases of human hypertension remains obscure and treatment remains suboptimal. Excessive dietary salt and inflammation are known contributors to the pathogenesis of this disease. Recently, it has been recognized that salt can accumulate in the skin and skeletal muscle producing concentrations of sodium greater than the plasma in hypertensive animals and humans. Such elevated levels of sodium have been shown to alter immune cell function...
November 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27901034/validity-and-reliability-of-the-dietary-sodium-restriction-questionnaire-in-patients-with-hypertension
#13
M P Rodrigues, E Rabelo-Silva, F D Fuchs, S C Fuchs, L B Moreira
The study aimed to evaluate the reliability and the validity of the dietary sodium restriction questionnaire (DSRQ) in patients with hypertension receiving outpatient treatment at a tertiary care university hospital in Southern Brazil. This instrument is composed of three subscales: attitude, subjective norm and perceived behavioral control. A total of 104 patients were included. They were 63.3±8.9 years old and 75% were females. Cronbach's alpha coefficient for the subscales of attitude, subjective norm and perceived behavioral control were 0...
November 30, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27898676/dietary-butyrate-helps-to-restore-the-intestinal-status-of-a-marine-teleost-sparus-aurata-fed-extreme-diets-low-in-fish-meal-and-fish-oil
#14
Itziar Estensoro, Gabriel Ballester-Lozano, Laura Benedito-Palos, Fabian Grammes, Juan Antonio Martos-Sitcha, Liv-Torunn Mydland, Josep Alvar Calduch-Giner, Juan Fuentes, Vasileios Karalazos, Álvaro Ortiz, Margareth Øverland, Ariadna Sitjà-Bobadilla, Jaume Pérez-Sánchez
There is a constant need to find feed additives that improve health and nutrition of farmed fish and lessen the intestinal inflammation induced by plant-based ingredients. The objective of this study was to evaluate the effects of adding an organic acid salt to alleviate some of the detrimental effects of extreme plant-ingredient substitution of fish meal (FM) and fish oil (FO) in gilthead sea bream diet. Three experiments were conducted. In a first trial (T1), the best dose (0.4%) of sodium butyrate (BP-70 ®NOREL) was chosen after a short (9-weeks) feeding period...
2016: PloS One
https://www.readbyqxmd.com/read/27891828/reducing-calories-fat-saturated-fat-and-sodium-in-restaurant-menu-items-effects-on-consumer-acceptance
#15
Anjali A Patel, Nanette V Lopez, Harry T Lawless, Valentine Njike, Mariana Beleche, David L Katz
OBJECTIVE: To assess consumer acceptance of reductions of calories, fat, saturated fat, and sodium to current restaurant recipes. METHODS: Twenty-four menu items, from six restaurant chains, were slightly modified and moderately modified by reducing targeted ingredients. Restaurant customers (n = 1,838) were recruited for a taste test and were blinded to the recipe version as well as the purpose of the study. Overall consumer acceptance was measured using a 9-point hedonic (like/dislike) scale, likelihood to purchase scale, Just-About-Right (JAR) 5-point scale, penalty analysis, and alienation analysis...
December 2016: Obesity
https://www.readbyqxmd.com/read/27889417/dietary-zinc-and-incident-calcium-kidney-stones-in-adolescence
#16
Gregory E Tasian, Michelle E Ross, Lihai Song, Robert W Grundmeier, James Massey, Michelle R Denburg, Lawrence Copelovitch, Steven Warner, Thomas Chi, David W Killilea, Marshall L Stoller, Susan L Furth
PURPOSE: To determine the association between dietary zinc intake and incident calcium kidney stones and examine the relationship between dietary zinc intake and urinary zinc excretion among adolescents. MATERIAL AND METHODS: This study was a nested case-control study conducted within a large pediatric healthcare system. Three 24-hour dietary recalls and spot urine chemistries were obtained for 30 participants aged 12-18 years with a first idiopathic calcium-based kidney stone and 30 healthy controls, matched on age, sex, race, and month of enrollment...
November 23, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27884237/diastolic-dysfunction-and-hypertension
#17
REVIEW
Wilson Nadruz, Amil M Shah, Scott D Solomon
Left ventricular (LV) diastolic dysfunction (LVDD) is characterized by alterations in LV diastolic filling, and is a strong predictor of cardiovascular events and heart failure. Hypertension is the most important risk factor for LVDD in the community and promotes LVDD through several mechanisms, including hemodynamic overload and myocardial ischemia. Associated factors such as age, ethnicity, dietary sodium, obesity, diabetes mellitus, and chronic kidney disease also contribute to LVDD in hypertensive individuals...
January 2017: Medical Clinics of North America
https://www.readbyqxmd.com/read/27882611/chronic-lactate-supplementation-does-not-improve-blood-buffering-capacity-and-repeated-high-intensity-exercise
#18
L F Oliveira, V de Salles Painelli, K Nemezio, L S Gonçalves, G Yamaguchi, B Saunders, B Gualano, G G Artioli
Since there is conflicting data on the buffering and ergogenic properties of calcium lactate (CL), we investigated the effect of chronic CL supplementation on blood pH, bicarbonate, and high-intensity intermittent exercise performance. Sodium bicarbonate (SB) was used as a positive control. Eighteen athletes participated in this double-blind, placebo-controlled, crossover, fully counterbalanced study. All participants underwent three different treatments: placebo (PL), CL, and SB. The dose was identical in all conditions: 500 mg/kg BM divided into four daily individual doses of 125 mg/kg BM, for five consecutive days, followed by a 2-7-day washout period...
November 23, 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/27881390/dietary-quality-of-the-us-child-and-adolescent-population-trends-from-1999-to-2012-and-associations-with-the-use-of-federal-nutrition-assistance-programs
#19
Xiao Gu, Katherine L Tucker
BACKGROUND: The state of the economy, changes in federal food assistance programs, and policies related to nutrition and the food supply in the United States may influence dietary quality in children and adolescents. OBJECTIVE: We investigated dietary quality trends from 1999 to 2012 in the US child and adolescent population and their associations with socioeconomic status and participation in federal food assistance programs. DESIGN: In this study, a nationally representative sample of 38,487 children and adolescents, aged 2-18 y, in the NHANES from 1999 to 2012 were included...
November 23, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27873228/hypertension-in-chronic-kidney-disease
#20
Seyed Mehrdad Hamrahian, Bonita Falkner
Hypertension, a global public health problem, is currently the leading factor in the global burden of disease. It is the major modifiable risk factor for heart disease, stroke and kidney failure. Chronic kidney disease (CKD) is both a common cause of hypertension and CKD is also a complication of uncontrolled hypertension. The interaction between hypertension and CKD is complex and increases the risk of adverse cardiovascular and cerebrovascular outcomes. This is particularly significant in the setting of resistant hypertension commonly seen in patient with CKD...
November 22, 2016: Advances in Experimental Medicine and Biology
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