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Non Epileptic Seizures

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https://www.readbyqxmd.com/read/29156220/the-epilepsy-phenotype-in-adult-patients-with-intellectual-disability-and-pathogenic-copy-number-variants
#1
Giuseppe d'Orsi, Tommaso Martino, Orazio Palumbo, Maria Grazia Pascarella, Pietro Palumbo, Maria Teresa Di Claudio, Carlo Avolio, Massimo Carella
PURPOSE: To characterize the electroclinical features of epilepsy associated with intellectual disability and pathogenic copy number variations (CNVs) METHODS: we prospectively investigated 61 adult patients with epilepsy and intellectual disability or other neurodevelopmental disorders. We performed high resolution SNP-Array analysis in order to detect clinical relevant chromosomal microdeletions and microduplications. An ordinal logistic regression model was fitted with 34 demographic, clinical and EEG-related variables in order to identify the epilepsy phenotype of patients with pathogenic CNVs...
November 14, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29152594/-blaming-shaming-humiliation-stigmatising-medical-interactions-among-people-with-non-epileptic-seizures
#2
Catherine Robson, Olaug S Lian
Background: People with non-epileptic seizures (NES) describe challenging relationships with health professionals, and explain negative interactions as common and expected. Despite these difficulties, little is known about how people with NES experience difficult healthcare encounters. Methods: Using a thematic discourse analysis approach, we analysed the free-text survey responses of 135 people with NES and asked: what kind of challenges do people living with this condition encounter when interacting with health professionals, and how do they experience the consequences of difficult interactions? We explore their experiences by interpreting the latent meaning of participants' texts from a social-constructionist perspective on health and illness...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/29133176/effect-of-zonisamide-on-refractory-epilepsy-during-pregnancy-in-lamotrigine-resistant-kindled-rats
#3
Reza Narenji Sani, Keivan Keramati, Niloufar Saberi, Melika Moezifar, Ali Mahdavi
Drug-resistant epilepsy with uncontrolled severe seizures despite state-of-the-art medical treatment continues to be a major clinical problem. Pregnancy is a state where drug pharmacokinetic changes are more pronounced and more rapid than any other period of life. The current study investigated the effect of zonisamide (ZNS) on refractory epilepsy during pregnancy in lamotrigine-resistant kindled rats. Fifty-six lamotrigine (LTG)-resistant kindled Wistar rats were divided into five experimental (four pregnant and one non-pregnant) and 2 positive controls (pregnant and non-pregnant) groups and eight intact Wistar rats were put in the negative pregnant control group...
November 11, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29132064/patients-and-caregivers-contributions-for-differentiating-epileptic-from-psychogenic-nonepileptic-seizures-value-and-limitations-of-self-reporting-questionnaires-a-pilot-study
#4
Giuseppe Erba, Elisa Bianchi, Giorgia Giussani, John Langfitt, Adam Juersivich, Ettore Beghi
PURPOSE: Questionnaires investigating semiology and comorbidities of psychogenic non-epileptic seizures (PNES) have been used mainly to help physicians expedite referrals to epilepsy centres for confirmation of diagnosis rather than as alternative diagnostic tool when video-EEG monitoring (VEM), the current gold standard, is not available or is inconclusive. METHODS: We developed one structured questionnaire for patients, exploring subjective experiences and vulnerabilities and one for eyewitnesses, focused on features observable during typical events to study prospectively 50 consecutive adult patients with PNES or epileptic seizures (ES) admitted for VEM...
November 8, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29131354/effect-of-status-epilepticus-on-expression-of-brain-udp-glucuronosyltransferase-1a-in-rats
#5
Yuki Asai, Hatsuna Tanaka, Masayuki Nadai, Miki Katoh
Status epilepticus (SE) involves severe epileptic seizures that cause oxidative stress in the brain. Oxidative stress is known to influence uridine 5'-diposphate-glucuronosyltransferase (UGT) 1A expression. The present study aimed at elucidating the effect of SE on Ugt1a1, Ugt1a6, and Ugt1a7 expression in the rat brain. Kainic acid was used to create an animal model of SE. Sprague-Dawley rats were treated intraperitoneally with 10 mg/kg kainic acid. Ugt1a1 and Ugt1a7 mRNA levels were increased by SE in the cortex and hippocampus (Ugt1a1: 4...
November 13, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/29124726/the-relation-between-cortisol-and-functional-connectivity-in-people-with-and-without-stress-sensitive-epilepsy
#6
Jonas M den Heijer, Willem M Otte, Eric van Diessen, Jolien S van Campen, E Lorraine Hompe, Floor E Jansen, Marian Joels, Kees P J Braun, Josemir W Sander, Maeike Zijlmans
OBJECTIVE: The most common reported seizure-precipitant is stress. We recently showed a biologic basis for stress sensitivity of seizures: cortisol levels in people with stress-sensitive epilepsy correlated with focal interictal epileptiform discharges (IEDs) on electroencephalography (EEG). Here we aimed to determine whether the effect of cortisol on the epileptic brain is global or focal, and whether cortisol affects all brains or just those of stress-sensitive people. Because epilepsy is associated with changes in functional brain connectivity, we studied the relationship between cortisol and changes in global and focal (node-centered) functional connectivity measures for individuals with stress-sensitive and non-stress-sensitive epilepsy...
November 10, 2017: Epilepsia
https://www.readbyqxmd.com/read/29115760/efficacy-and-safety-of-cannabis-for-treating-children-with-refractory-epilepsy
#7
Michelle Neale
The aim of this literature review was to examine the evidence base for the safety and efficacy of cannabis in treating children with refractory epilepsy. Clinical and medical databases were searched and four articles were included in the final analysis, which included retrospective reviews and open-label trials with a total sample size of 424. One clinical trial included administration of cannabidiol, the non-psychoactive compound of cannabis, while the other three articles stated that the compound administered to participants contained tetrahydrocannabidiol, the psychoactive constituent of cannabis...
September 11, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/29109857/an-optimum-allocation-sampling-based-feature-extraction-scheme-for-distinguishing-seizure-and-seizure-free-eeg-signals
#8
Sachin Taran, Varun Bajaj, Siuly Siuly
Epileptic seizure is the common neurological disorder, which is generally identified by electroencephalogram (EEG) signals. In this paper, a new feature extraction methodology based on optimum allocation sampling (OAS) and Teager energy operator (TEO) is proposed for detection of seizure EEG signals. The OAS scheme selects the finite length homogeneous sequence from non-homogeneous recorded EEG signal. The trend of selected sequence by OAS is still non-linear, which is analyzed by non-linear operator TEO. The TEO convert non-linear but homogenous EEG sequence into amplitude-frequency modulated (AM-FM) components...
December 2017: Health Information Science and Systems
https://www.readbyqxmd.com/read/29108660/usefulness-of-electroencephalography-for-the-management-of-epilepsy-in-emergency-departments
#9
A Viloria Alebesque, A López Bravo, E Bellosta Diago, S Santos Lasaosa, J A Mauri Llerda
INTRODUCTION: Electroencephalography (EEG) is an essential diagnostic tool in epilepsy. Its use in emergency departments (ED) is usually restricted to the diagnosis and management of non-convulsive status epilepticus (NCSE). However, EDs may also benefit from EEG in the context of other situations in epilepsy. METHODS: We conducted a retrospective observational study using the clinical histories of patients treated at our hospital's ED for epileptic seizures and suspicion of NCSE and undergoing EEG studies in 2015 and 2016...
November 3, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29102710/how-to-choose-a-practicable-duration-time-for-capturing-paroxysmal-events-by-prolonged-video-electroencephalogram-monitoring-in-the-elderly
#10
Jianhua Chen, Xiangqin Zhou, Yan Huang, Qiang Lu, Liri Jin, Heyang Sun
PURPOSE: To measure association between paroxysmal events and length of monitoring to identify a practicable duration time for capturing seizures in the elderly. METHODS: Consecutive inpatients 60 years and older who were admitted to the Epilepsy Center and underwent prolonged video electroencephalogram (VEEG) monitoring (VEM) were reviewed retrospectively. Electronic medical records were reviewed to collect information regarding sex, age at onset of symptoms and examination, concurrent epilepsy, frequency of seizures, diagnosis before and after examination, antiepileptic drugs (AEDs), brain magnetic resonance imaging (MRI), and VEEG findings...
November 2, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29101825/epileptic-seizure-or-not-proportion-of-correct-judgement-based-only-on-a-video-recording-of-a-paroxysmal-event
#11
Eszter Nagy, Alexandra Major, Nelli Farkas, Katalin Hollódy
PURPOSE: Our study was intended to measure the proportion of correct seizure recognition among different medical and non-medical groups based on only a video recording. METHODS: Video recordings about paroxysmal movements of 15 very young infants (2days - 5 months of age) were displayed for six groups: 159 1st-year medical students, 65 4-5th-year medical students, 52 paediatric residents, 18 paediatric neurologists from different European countries, 43 adult neurologists and 37 parents whose children were treated at our Department...
September 6, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29096665/genotype-phenotype-correlations-and-expansion-of-the-molecular-spectrum-of-ap4m1-related-hereditary-spastic-paraplegia
#12
Conceição Bettencourt, Vincenzo Salpietro, Stephanie Efthymiou, Viorica Chelban, Deborah Hughes, Alan M Pittman, Monica Federoff, Thomas Bourinaris, Martha Spilioti, Georgia Deretzi, Triantafyllia Kalantzakou, Henry Houlden, Andrew B Singleton, Georgia Xiromerisiou
BACKGROUND: Autosomal recessive hereditary spastic paraplegia (HSP) due to AP4M1 mutations is a very rare neurodevelopmental disorder reported for only a few patients. METHODS: We investigated a Greek HSP family using whole exome sequencing (WES). RESULTS: A novel AP4M1A frameshift insertion, and a very rare missense variant were identified in all three affected siblings in the compound heterozygous state (p.V174fs and p.C319R); the unaffected parents were carriers of only one variant...
November 2, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29096164/potential-factors-impacting-health-related-quality-of-life-among-patients-with-epilepsy-results-from-the-united-arab-emirates
#13
Taoufik Alsaadi, Seada Kassie, Khadija El Hammasi, Tarek M Shahrour, Mustafa Shakra, Lamya Turkawi, Wassim Nasreddine, Mufeed Raoof
PURPOSE: to investigate potential factors impacting HRQOL among PWE at a medical facility in the UAE. METHODS: Depression, anxiety, and health-related quality of life were assessed in 160 adult patients with epilepsy from September 2014 to January 2015 at Sheikh Khalifa Medical City (SKMC). The World Health Organization Quality of Life abbreviated scale (WHOQOL-BREF), the Patient Health Questionnaire nine-item (PHQ-9) depression scale, and Generalized Anxiety Disorder seven-item (GAD-7) scale were administered...
October 28, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29090671/targeted-blockade-of-tarp-g8-associated-ampa-receptors-anticonvulsant-activity-with-the-selective-antagonist-ly3130481-cerc-611
#14
Jeffrey M Witkin, Douglas A Schober, Scott D Gleason, John T Catlow, Warren J Porter, Jon Reel, X Jin, J Hobbs, Donald Gehlert, Douglas L Gernert, Kevin M Gardinier, Akihiko S Kato, X Ping, J L Smith
6-[(1S)-1-[1-[5-(2-hydroxyethoxy)-2-pyridyl]pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one (LY3130481 or CERC-611) is a selective antagonist of AMPA receptors containing transmembrane AMPA receptor regulatory protein (TARP) g-8 that is under development for epilepsy. The present study provided a broad inquiry into its anticonvulsant properties. LY3130481 was anticonvulsant in multiple acute seizure provocation models in mice and rats. In addition, LY3130481 was effective against absence seizures in the GAERS genetic model and in the Frings mouse model...
November 1, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29076422/the-prophylactic-use-of-antiepileptic-drugs-in-patients-scheduled-for-neurosurgery
#15
Barbara Miziak, Kinga Borowicz-Reutt, Radoslaw Rola, Barbara Blaszczyk, Miroslaw Czuczwar, Stanislaw J Czuczwar
Antiepileptic drugs (AEDs) possess diverse mechanisms of action - enhancement of GABA-mediated events, inhibition of glutamate-mediated excitation, blockade of voltage-dependent sodium or calcium channels being the most frequently shared. They are not only used for the symptomatic management of epilepsy but in the treatment of psychiatric or neurologic disorders (e.g. bipolar disorder, neuropathic pain, prophylaxis of migraine). Generally, this group of drugs is also widely used in neurosurgery patients for the prevention of seizure activity and their effectiveness in this regard has been evaluated in this review...
October 27, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29060483/epileptic-seizure-detection-based-on-expected-activity-measurement-and-neural-network-classification
#16
Imen Dhif, Khalil Hachicha, Andrea Pinna, Sylvain Hochberg, Imen Mhedhbi, Patrick Garda
Epilepsy is known as the second reason to visit a neurophysiologist after migraine. In this paper, we propose a new approach to automatically detect crises of epilepsy in an Electroencephalogram (EEG). Our algorithm is based on image transformation, Wavelet Decomposition (DWT) and taking advantage of the correlation between wavelet coefficients in each sub-band. Therefore, an Expected Activity Measurement (EAM) is calculated for each coefficient as a feature extraction method. These features are fed into back propagation Neural Network (ANN) and the periods with epileptic seizures and non-seizures are classified...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29054038/epileptic-headache-a-rare-form-of-painful-seizure
#17
REVIEW
Carlo Cianchetti, Filippo Dainese, Maria Giuseppina Ledda, Giuliano Avanzini
PURPOSE: To describe the concept, features and mechanisms of epileptic headache (EH). METHODS: Analysis of all published articles concerning EH and related subjects. RESULTS: There are more than 30 published case studies of patients with headache as the only manifestation of a seizure, a condition that has been variously called "EH", "ictal epileptic headache", "hemicrania epileptica", "cephalic pain seizure". It is necessary to differentiate EH from "migralepsy" and "ictal non-epileptic headache"...
October 13, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29053782/seizure-onset-zone-localization-using-postictal-hypoperfusion-detected-by-arterial-spin-labelling-mri
#18
Ismael Gaxiola-Valdez, Shaily Singh, Tefani Perera, Sherry Sandy, Emmy Li, Paolo Federico
Neurological dysfunction following epileptic seizures is a well-recognized phenomenon. Several potential mechanisms have been suggested to explain postictal dysfunction, with alteration in cerebral blood flow being one possibility. These vascular disturbances may be long lasting and localized to brain areas involved in seizure generation and propagation, as supported by both animal and human studies. Therefore, measuring perfusion changes in the postictal period may help localize the seizure onset zone. Arterial spin labelling is a non-invasive, rapid and reproducible magnetic resonance imaging technique that measures cerebral perfusion...
November 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29050866/seizure-semiology-in-leucine-rich-glioma-inactivated-protein-1-antibody-associated-limbic-encephalitis
#19
Chao Chen, Xiu Wang, Chao Zhang, Tao Cui, Wei-Xiong Shi, Hong-Zhi Guan, Hai-Tao Ren, Xiao-Qiu Shao
OBJECTIVE: The objective of this study was to advance the characterization of seizure semiology in leucine-rich glioma-inactivated protein 1 (LGI1) antibody-associated limbic encephalitis (LE). METHODS: Eighteen patients diagnosed with LGI1 LE were identified. Seizure semiology, demographic features, MRI and fluorodeoxyglucose positron emission tomography (FDG-PET), electroencephalograms, and outcomes following immunotherapy were evaluated. RESULTS: Patients were divided into the following groups based on seizure semiology: faciobrachial dystonic seizure only (FBDS-only, n=4), epileptic seizure without FBDS (Non-FBDS, n=6), and FBDS plus epileptic seizure (FBDS+, n=8)...
October 16, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29037447/a-quinidine-non-responsive-novel-kcnt1-mutation-in-an-indian-infant-with-epilepsy-of-infancy-with-migrating-focal-seizures
#20
Priyanka Madaan, Prashant Jauhari, Aparajita Gupta, Biswaroop Chakrabarty, Sheffali Gulati
Epilepsy of infancy with migrating focal seizures {a.k.a malignant migrating partial seizures of infancy (MMPSI)} is an uncommon epileptic encephalopathy with a poor prognosis. Migrating focal seizures with autonomic features, developmental stagnation and refractoriness to treatment are its key features. It is caused by genetic defects in various ion channels, most common being sodium activated potassium channel (KCNT1), found in up to 50% of cases. With advent of genetic diagnosis and precision medicine, many targeted therapies have been identified...
October 13, 2017: Brain & Development
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