keyword
https://read.qxmd.com/read/38546973/changes-in-public-attitude-toward-epilepsy-in-hungary-since-1994-a-multicriteria-weighting-analysis
#1
JOURNAL ARTICLE
Mengesha Srahbzu Biresaw, József Vitrai, Péter Halász, Vivian Correa, Anna Szűcs
OBJECTIVE: To assess the adult Hungarian population's knowledge about and attitude toward epilepsy and compare the present findings with previous ones in 1994 and 2000. METHODS: We performed a cross-sectional survey of the Hungarian adult population from 28th February to 8th March 2023. A non-probability quota sampling with a random walk method was used. We applied the computer-assisted personal interviewing (CAPI) method and used a multicriteria weighting procedure to correct for bias along the main sociodemographic variables...
March 28, 2024: Epilepsia Open
https://read.qxmd.com/read/38544349/idiopathic-generalized-epilepsy-in-a-family-with-scn4a-related-myotonia
#2
JOURNAL ARTICLE
Mariagrazia Talarico, Francesco Fortunato, Audrey Labalme, Louis Januel, Nicolas Chatron, Damien Sanlaville, Ilaria Sammarra, Monica Gagliardi, Radha Procopio, Paola Valentino, Grazia Annesi, Gaetan Lesca, Antonio Gambardella
OBJECTIVES: Myotonia is a clinical sign typical of a group of skeletal muscle channelopathies, the non-dystrophic myotonias. These disorders are electrophysiologically characterized by altered membrane excitability, due to specific genetic variants in known causative genes (CLCN1 and SCN4A). Juvenile Myoclonic Epilepsy (JME) is an epileptic syndrome identified as idiopathic generalized epilepsy, its genetics is complex and still unclarified. The co-occurrence of these two phenotypes is rare and the causes likely have a genetic background...
March 27, 2024: Epilepsia Open
https://read.qxmd.com/read/38539105/genetic-determinants-of-global-developmental-delay-and-intellectual-disability-in-ukrainian-children
#3
JOURNAL ARTICLE
Khrystyna Shchubelka, Liudmyla Turova, Walter Wolfsberger, Kelly Kalanquin, Krista Williston, Oleksii Kurutsa, Anastasiia Makovetska, Yaroslava Hasynets, Violeta Mirutenko, Mykhailo Vakerych, Taras K Oleksyk
BACKGROUND: Global developmental delay or intellectual disability usually accompanies various genetic disorders as a part of the syndrome, which may include seizures, autism spectrum disorder and multiple congenital abnormalities. Next-generation sequencing (NGS) techniques have improved the identification of pathogenic variants and genes related to developmental delay. This study aimed to evaluate the yield of whole exome sequencing (WES) and neurodevelopmental disorder gene panel sequencing in a pediatric cohort from Ukraine...
March 27, 2024: Journal of Neurodevelopmental Disorders
https://read.qxmd.com/read/38536031/stimulating-the-cingulate-to-move
#4
JOURNAL ARTICLE
An Qi Xu, Nicolas Nguyen, Elie Bou Assi, Dang Khoa Nguyen
No abstract text is available yet for this article.
March 27, 2024: Epileptic Disorders: International Epilepsy Journal with Videotape
https://read.qxmd.com/read/38531502/low-frequency-stimulation-for-seizure-suppression-identification-of-optimal-targets-in-the-entorhinal-hippocampal-circuit
#5
JOURNAL ARTICLE
Piret Kleis, Enya Paschen, Ute Häussler, Carola A Haas
BACKGROUND: Mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS) is a common form of drug-resistant focal epilepsy in adults. Treatment for pharmacoresistant patients remains a challenge, with deep brain stimulation (DBS) showing promise for alleviating intractable seizures. This study explores the efficacy of low-frequency stimulation (LFS) on specific neuronal targets within the entorhinal-hippocampal circuit in a mouse model of MTLE. OBJECTIVE: /Hypothesis: Our previous research demonstrated that LFS of the medial perforant path (MPP) fibers in the sclerotic hippocampus reduced seizures in epileptic mice...
March 24, 2024: Brain Stimulation
https://read.qxmd.com/read/38529038/epilepsy-related-functional-brain-network-alterations-are-already-present-at-an-early-age-in-the-gaers-rat-model-of-genetic-absence-epilepsy
#6
JOURNAL ARTICLE
Lydia Wachsmuth, Leo Hebbelmann, Jutta Prade, Laura C Kohnert, Henriette Lambers, Annika Lüttjohann, Thomas Budde, Andreas Hess, Cornelius Faber
INTRODUCTION: Genetic Absence Epilepsy Rats from Strasbourg (GAERS) represent a model of genetic generalized epilepsy. The present longitudinal study in GAERS and age-matched non-epileptic controls (NEC) aimed to characterize the epileptic brain network using two functional measures, resting state-functional magnetic resonance imaging (rs-fMRI) and manganese-enhanced MRI (MEMRI) combined with morphometry, and to investigate potential brain network alterations, following long-term seizure activity...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38523977/interventions-to-improve-medication-adherence-in-children-with-epilepsy-a-systematic-review
#7
REVIEW
Karishma Godara, Nisha Phakey, Divyani Garg, Suvasini Sharma, Rashmi R Das
Low medication adherence remains a major challenge in the treatment of epilepsy, particularly in children. In recent years, several approaches and interventions have been employed to promote medication adherence in children with epilepsy (CWE). In this study, we aimed to summarize the evidence on these interventions. In this systematic review, major medical electronic databases were searched for relevant literature from January 2005 till July 2023, including PsycINFO, Medline (via PubMed), Google Scholar, Taylor & Francis databases, and CENTRAL by the Cochrane Library...
February 2024: Curēus
https://read.qxmd.com/read/38523714/isoflurane-treatment-for-refractory-and-super-refractory-status-epilepticus-in-dogs
#8
JOURNAL ARTICLE
Eirini Sarpekidou, Georgios Polyzois, Virginia Papageorgiou, Ioannis Savvas, Zoe Polizopoulou, George Kazakos
INTRODUCTION: Resistant epileptic episodes, such as refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE), are neurological emergencies that require immediate medical treatment. Although inhalational anesthetics, such as isoflurane (ISO), have been proposed as a means of seizure control in dogs, there is currently a lack of both experimental and clinical studies on this subject. STUDY DESIGN: This is a retrospective clinical study. METHODS: Records of dogs that received ISO for the management of RSE and SRSE during their intensive care unit (ICU) hospitalization at the Companion Animal Clinic of the Aristotle University of Thessaloniki were included in the present study...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38521160/mitochondria-targeting-peptide-ss-31-attenuates-ferroptosis-via-inhibition-of-the-p38-mapk-signaling-pathway-in-the-hippocampus-of-epileptic-rats
#9
JOURNAL ARTICLE
Xue Liu, Fei-Yu Wang, Song Chi, Tao Liu, Hai-Lin Yang, Ru-Jie Zhong, Xiao-Yu Li, Jing Gao
Ferroptosis is a newly identified form of non-apoptotic regulated cell death (RCD) andplaysanimportantrole in epileptogenesis. The p38 mitogen-activated protein kinase (p38 MAPK) pathway has been confirmed to be involved in ferroptosis. The mitochondria-targeting antioxidant Elamipretide (SS-31) can reduce the generation of lipid peroxidation and the buildup of reactive oxygen species (ROS). Collectively, our present study was to decipher whether SS-31 inhibits ferroptosis via the p38 MAPK signaling pathway in the rat epilepsy model induced by pilocarpine (PILO)...
March 21, 2024: Brain Research
https://read.qxmd.com/read/38521027/breathing-control-training-for-functional-seizures-a-multi-site-open-label-pilot-study
#10
JOURNAL ARTICLE
Roderick Duncan, David J Berlowitz, Saul Mullen, Janet Bondarenko, Toby T Winton-Brown, Terence J O'Brien, Sophie Zaloumis, Sabine Braat, Georgina Oliver, Richard A Kanaan
There are no well-validated treatments for functional seizures. While specialist psychotherapy is usually recommended, the evidence for its benefit is qualified, and it can be difficult to obtain. Given the association between hyperventilation and functional seizures we explored an alternative modality, breathing control training, in a multi-site open label pilot trial. Participants with functional seizures over the age of 16 received an hour of breathing training from a respiratory physiotherapist, with a half-hour booster session a month later...
March 22, 2024: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/38518671/what-we-have-learned-from-non-human-primates-as-animal-models-of-epilepsy
#11
JOURNAL ARTICLE
Viviam Sanabria, Simone A A Romariz, Matheus Braga, Jaime Moreira Pires, Maria da Graça Naffah-Mazzacoratti, Luiz Eugênio Mello, Beatriz M Longo, Maira Licia Foresti
Non-human primates (NHPs) have played a crucial role in our understanding of epilepsy, given their striking similarities with humans. Through their use, we have gained a deeper understanding of the neurophysiology and pathophysiology of epileptic seizures, and they have proven invaluable allies in developing anti-seizure therapies. This review explores the history of NHPs as natural models of epilepsy, discusses the findings obtained after exposure to various chemoconvulsant drugs and focal electrical stimulation protocols that helped uncover important mechanisms related to epilepsy, examines diverse treatments to prevent and manage epilepsy, and addresses essential ethical issues in research...
March 21, 2024: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/38513569/edeeplepsy-an-artificial-neural-framework-to-reveal-different-brain-states-in-children-with-epileptic-spasms
#12
JOURNAL ARTICLE
Alberto Nogales, Álvaro J García-Tejedor, Juan Serrano Vara, Arturo Ugalde-Canitrot
OBJECTIVE: Despite advances, analysis and interpretation of EEG still essentially rely on visual inspection by a super-specialized physician. Considering the vast amount of data that composes the EEG, much of the detail inevitably escapes ordinary human scrutiny. Significant information may not be evident and is missed, and misinterpretation remains a serious problem. Can we develop an artificial intelligence system to accurately and efficiently classify EEG and even reveal novel information? In this study, deep learning techniques and, in particular, Convolutional Neural Networks, have been used to develop a model (which we have named eDeeplepsy) for distinguishing different brain states in children with epilepsy...
March 20, 2024: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/38512531/primary-vs-pre-emptive-anti-seizure-medication-prophylaxis-in-anti-cd19-car-t-cell-therapy
#13
JOURNAL ARTICLE
Umberto Pensato, Federica Pondrelli, Chiara de Philippis, Gian Maria Asioli, Alessandra Crespi, Alessandro Buizza, Daniele Mannina, Beatrice Casadei, Enrico Maffini, Laura Straffi, Simona Marcheselli, Pier Luigi Zinzani, Francesca Bonifazi, Maria Guarino, Stefania Bramanti
INTRODUCTION: Seizures may occur in up to 30% of non-Hodgkin lymphoma patients who received anti-CD19 CAR T-cell therapy, yet the optimal anti-seizure medication (ASM) prevention strategy has not been thoroughly investigated. METHODS: Consecutive patients affected by refractory non-Hodgkin lymphoma who received anti-CD19 CAR T-cells were included. Patients were selected and assessed using similar internal protocols. ASM was started either as a primary prophylaxis (PP-group) before CAR T-cells infusion or as a pre-emptive therapy (PET-group) only upon the onset of neurotoxicity development...
March 21, 2024: Neurological Sciences
https://read.qxmd.com/read/38508705/-zfhx3-variants-cause-childhood-partial-epilepsy-and-infantile-spasms-with-favourable-outcomes
#14
JOURNAL ARTICLE
Ming-Feng He, Li-Hong Liu, Sheng Luo, Juan Wang, Jia-Jun Guo, Peng-Yu Wang, Qiong-Xiang Zhai, Su-Li He, Dong-Fang Zou, Xiao-Rong Liu, Bing-Mei Li, Hai-Yan Ma, Jing-Da Qiao, Peng Zhou, Na He, Yong-Hong Yi, Wei-Ping Liao
BACKGROUND: The ZFHX3 gene plays vital roles in embryonic development, cell proliferation, neuronal differentiation and neuronal death. This study aims to explore the relationship between ZFHX3 variants and epilepsy. METHODS: Whole-exome sequencing was performed in a cohort of 378 patients with partial (focal) epilepsy. A Drosophila Zfh2 knockdown model was used to validate the association between ZFHX3 and epilepsy. RESULTS: Compound heterozygous ZFHX3 variants were identified in eight unrelated cases...
March 20, 2024: Journal of Medical Genetics
https://read.qxmd.com/read/38507373/a-secure-and-interpretable-ai-for-smart-healthcare-system-a-case-study-on-epilepsy-diagnosis-using-eeg-signals
#15
JOURNAL ARTICLE
Ijaz Ahmad, Mingxing Zhu, Guanglin Li, Danish Javeed, Prabhat Kumar, Shixiong Chen
The efficient patient-independent and interpretable framework for electroencephalogram (EEG) epileptic seizure detection (ESD) has informative challenges due to the complex pattern of EEG nature. Automated detection of ES is crucial, and Explainable Artificial Intelligence (XAI) is urgently needed to justify algorithmic predictions in clinical settings. Therefore, this study implements an XAI-based computer-aided ES detection system (XAI-CAESDs), comprising three major modules including of feature engineering module, a seizure detection module, and an explainable decision-making process module in a smart healthcare system...
March 20, 2024: IEEE Journal of Biomedical and Health Informatics
https://read.qxmd.com/read/38506017/strange-episodes-during-sleep-epilepsy-or-parasomnia
#16
JOURNAL ARTICLE
Oliver Henning, Rune Markhus, Eva Elisabeth Jansen Dornish, Konstantin Hrisimirov Kostov, Fridny Heimisdottir, Karl O Nakken
In some forms of epilepsy, the seizures occur almost exclusively during sleep. This is particularly the case with hypermotor frontal lobe seizures. Clinically it can be difficult to distinguish such seizures from parasomnias and psychogenic non-epileptic seizures. This clinical review article aims to highlight the importance of making the correct diagnosis, as these conditions require completely different treatment.
March 19, 2024: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://read.qxmd.com/read/38491955/modification-of-brain-conductivity-in-human-focal-epilepsy-a-model-based-estimation-from-stereoelectroencephalography
#17
JOURNAL ARTICLE
Stanislas Lagarde, Julien Modolo, Maxime Yochum, Andres Carvallo, Alice Ballabeni, Didier Scavarda, Romain Carron, Nathalie Villeneuve, Fabrice Bartolomei, Fabrice Wendling
OBJECTIVE: We have developed a novel method for estimating brain tissue electrical conductivity using low-intensity pulse stereoelectroencephalography (SEEG) stimulation coupled with biophysical modeling. We evaluated the hypothesis that brain conductivity is correlated with the degree of epileptogenicity in patients with drug-resistant focal epilepsy. METHODS: We used bipolar low-intensity biphasic pulse stimulation (.2 mA) followed by a postprocessing pipeline for estimating brain conductivity...
March 16, 2024: Epilepsia
https://read.qxmd.com/read/38477959/point-prevalence-of-epilepsy-in-dementia-a-real-world-estimate
#18
JOURNAL ARTICLE
Antonella Muroni, Gianluca Floris, Giuseppe Borghero, Silvia Ardu, Maria Ida Pateri, Silvy Pilotto, Giada Pisano, Giovanni Defazio
OBJECTIVE: Several studies have demonstrated a higher frequency of seizures and epilepsy in Alzheimer's disease and other forms of dementia as compared with healthy elderly individuals. However, incidence and prevalence of epilepsy in the general population of dementia are unknown since most previous studies were performed in secondary-tertiary referral centres. In addition, all prior studies but one provided "period" rather than "point" prevalence estimates. METHODS: We assessed point prevalence estimate of epileptic manifestations requiring antiepileptic medication in patients Alzheimer's disease, vascular dementia, and fronto-temporal dementia from a secondary clinical setting...
March 13, 2024: Epileptic Disorders: International Epilepsy Journal with Videotape
https://read.qxmd.com/read/38472033/brain-mri-in-status-epilepticus-relevance-of-findings
#19
REVIEW
T Bonduelle, M Ollivier, A Gradel, J Aupy
Status epilepticus (SE) represents one of the most common neurological emergencies, associated with high mortality and an important risk of functional sequelae in survivors. Magnetic resonance imaging (MRI) offers the possibility of early and noninvasive observation of seizure-induced parenchymal disturbances secondary to the epileptic process. In the present review, we propose a descriptive and comprehensive understanding of current knowledge concerning seizure-induced MRI abnormalities in SE, also called peri-ictal MRI abnormalities (PMAs)...
March 11, 2024: Revue Neurologique
https://read.qxmd.com/read/38469571/locus-coeruleus-features-are-linked-to-vagus-nerve-stimulation-response-in-drug-resistant-epilepsy
#20
JOURNAL ARTICLE
Alexandre Berger, Elise Beckers, Vincent Joris, Gaëtan Duchêne, Venethia Danthine, Nicolas Delinte, Inci Cakiroglu, Siya Sherif, Enrique Ignacio Germany Morrison, Andres Torres Sánchez, Benoit Macq, Laurence Dricot, Gilles Vandewalle, Riëm El Tahry
The locus coeruleus-norepinephrine system is thought to be involved in the clinical effects of vagus nerve stimulation. This system is known to prevent seizure development and induce long-term plastic changes, particularly with the release of norepinephrine in the hippocampus. However, the requisites to become responder to the therapy and the mechanisms of action are still under investigation. Using MRI, we assessed the structural and functional characteristics of the locus coeruleus and microstructural properties of locus coeruleus-hippocampus white matter tracts in patients with drug-resistant epilepsy responding or not to the therapy...
2024: Frontiers in Neuroscience
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