Sophie I Nagelkerken, Peter H Neeskens, Joris I Rotmans, Volker Nickeleit, Jan A Bruijn, Ingeborg M Bajema
Glomerular fibrillary deposits have occasionally been reported in diabetic nephropathy, but no large-scale, ultrastructural evaluation of these deposits have been reported so far. Here, we report our study of glomerular non-Congophilic, DNAJB9 negative fibrillary deposits in diabetic nephropathy as characterized by transmission electron microscopy. Clinical data from 55 patients with biopsy-confirmed diabetic nephropathy and 18 healthy living donors were reviewed, and their biopsies evaluated by light microscopy, immunofluorescence, and electron microscopy...
December 29, 2023: Laboratory Investigation; a Journal of Technical Methods and Pathology