Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Cheol-Jung Lee, Heejung Lee, Seo Ree Kim, Soo-Bin Nam, Ga-Eun Lee, Kyeong Eun Yang, Guk Jin Lee, Sang Hoon Chun, Han Chang Kang, Joo Young Lee, Hye Suk Lee, Sung-Jun Cho, Yong-Yeon Cho
Accumulating evidence demonstrates that the activity regulation of ELK3, a member of the E26 transformation-specific oncogene family, is critical to regulating cell proliferation, migration, and survival in human cancers. However, the molecular mechanisms of how ELK3 induces chemoresistance in prostate cancer (PCa) have not been elucidated. In this study, we found that SPOP and ELK3 are an interacting partner. The interaction between SPOP and ELK3 resulted in increased ELK3 ubiquitination and destruction, assisted by checkpoint kinase-mediated ELK3 phosphorylation...
April 17, 2024: Cell Death & Disease
#2
JOURNAL ARTICLE
Yan Yu, Yang Li, Yu Liu, Xiao-Xiao Ling, Li-Guang Wu, Li Yang, Lan Yang, Bo Yang, Yong-Gang Zhao, Xian-Hua Li
The Chinese Bayan Obo deposit is a world-class rare earth element (REE) deposit with considerable niobium (Nb) and iron (Fe) resources. A complete genetic understanding on all metals is fundamental for establishing genetic models at Bayan Obo. With extensive research being focused on REE enrichment, the timing and controls of Nb enrichment remain unresolved at Bayan Obo, which is mainly due to the challenges in dating, i.e. multistage thermal events, fine-grained minerals with complex textures and the rare occurrence of uranium-enriched minerals with mature dating methods...
April 2024: National Science Review
#3
JOURNAL ARTICLE
Shengpeng Yan, Shengwen Xu, Shihan Lei, Yuan Gao, Keyi Chen, Xiaoyu Shi, Yingying Guo, Nataliya Bilyera, Ming Yuan, Huaiying Yao
The increased usage of rare earth elements (REEs) leads to the extensive exploitation of rare earth mines, and the REEs pollution in soil caused by the legacy mine tailings has brought great harm to environment and human health. Although Phytolacca americana can remove REEs from contaminated soil to some extent, there is still an urgent problem to improve its efficiency. Hyperaccumulator extract is a new organic material with potential in metal phytoextraction, but its role in REEs phytoremediation and the related underlying processes remain unclear...
April 13, 2024: Environmental Research
#4
JOURNAL ARTICLE
Conor M E Phelan, Erik Björklund, Jasper Singh, Michael Fraser, Pravin N Didwal, Gregory J Rees, Zachary Ruff, Pilar Ferrer, David C Grinter, Clare P Grey, Robert S Weatherup
The cathode-electrolyte interphase (CEI) in Li-ion batteries plays a key role in suppressing undesired side reactions while facilitating Li-ion transport. Ni-rich layered cathode materials offer improved energy densities, but their high interfacial reactivities can negatively impact the cycle life and rate performance. Here we investigate the role of electrolyte salt concentration, specifically LiPF6 (0.5-5 m ), in altering the interfacial reactivity of charged LiN0.8 Mn0.1 Co0.1 O2 (NMC811) cathodes in standard carbonate-based electrolytes (EC/EMC vol %/vol % 3:7)...
April 9, 2024: Chemistry of Materials: a Publication of the American Chemical Society
#5
REVIEW
Jung Hoon Lee, Seungyeop Oh, Kihun Kim, Dongjun Lee, Eunjeong Son, Tae Woo Kim, Tae Sik Goh, Noo Ree Cho, Yun Hak Kim
Obesity is a potential risk factor for meniscal tear (MT). We utilized meta-analysis of observational studies and Mendelian randomization (MR) analyses to elucidate the association between body mass index (BMI) and MT. In meta-analysis, a search was performed on June 27, 2022, using PubMed and Embase databases. Odds ratios and 95% confidence intervals were extracted from included studies. In MR analyses, the research utilized summary-level data on BMI and MT obtained from Genetic Investigation of Anthropometric Traits and the FinnGen Consortium, respectively...
April 14, 2024: Obesity Reviews
#6
JOURNAL ARTICLE
Zoe Tasma, Tayla A Rees, Song Guo, Sheryl Tan, Simon J O'Carroll, Richard L M Faull, Maurice A Curtis, Sarah L Christensen, Debbie L Hay, Christopher S Walker
BACKGROUND AND PURPOSE: The spinal cord is a key structure involved in the transmission and modulation of pain. Pituitary adenylate cyclase-activating peptide (PACAP) and vasoactive intestinal peptide (VIP), are expressed in the spinal cord. These peptides activate G protein-coupled receptors (PAC1 , VPAC1 and VPAC2 ) that could provide targets for the development of novel pain treatments. However, it is not clear which of these receptors are expressed within the spinal cord and how these receptors signal...
April 14, 2024: British Journal of Pharmacology
#7
JOURNAL ARTICLE
Marta Cunha, Alessandro Nardi, Bruno Henriques, Amadeu M V M Soares, Eduarda Pereira, Francesco Regoli, Rosa Freitas
Rare earth elements (REEs) are increasingly being studied mainly due to their economic importance and wide range of applications, but also for their rising environmental concentrations and potential environmental and ecotoxicological impacts. Among REEs, neodymium (Nd) is widely used in lasers, glass additives, and magnets. Currently, NdFeB-based permanent magnets are the most significant components of electronic devices and Nd is used because of its magnetic properties. In addition to REES, part of the environmental pollution related to electrical and electronic equipment, fluorescent lamps and batteries also comes from mercury (Hg)...
April 12, 2024: Chemosphere
#8
JOURNAL ARTICLE
Cerium Oxide and Neodymium Oxide Phytoextraction by Ryegrass in Bioenhanced Hydroponic Environments.
Maedeh Soleimanifar, Lucia Rodriguez-Freire
Sustainable technologies for the recovery of rare earth elements (REE) from waste need to be developed to decrease the volume of ore mining extractions and its negative environmental consequences, while simultaneously restoring previously impacted lands. This is critical due to the extensive application of REE in everyday life from electronic devices to energy and medical technologies, and the dispersed distribution of REE resources in the world. REE recovery by plants has been previously studied but the feasibility of REE phytoextraction from a poorly soluble solid phase (i...
April 12, 2024: Environmental Pollution
#9
JOURNAL ARTICLE
Antonios Apostolos Brouziotis, Susanne Heise, Lorenzo Saviano, Keran Zhang, Antonella Giarra, Michael Bau, Franca Tommasi, Marco Guida, Giovanni Libralato, Marco Trifuoggi
The essential utilization of rare earth elements (REEs) for the production of several electronic devices is making the demand for them being increased all the time. This extensive use of these elements has also increased concern about human and environmental health. Previous studies have shown that REE levels are higher in environmental samples near mining sites, and they are highly possible to be transferred to biota. In this study, REE levels were determined in environmental samples collected from three abandoned mining sites of bauxite (Gargano, Otranto, and Spinazzola) in the region of Puglia, Southern Italy...
April 10, 2024: Talanta
#10
JOURNAL ARTICLE
Hossain Shadman, Jesse D Ziebarth, Caleb E Gallops, Ray Luo, Zhengxin Li, Hai-Feng Chen, Yongmei Wang
Disordered proteins are conformationally flexible proteins that are biologically important and have been implicated in devastating diseases such as Alzheimer's and cancer. Unlike stably-folded structured proteins, disordered proteins sample a range of different conformations that needs to be accounted for. Here, we treat disordered proteins as polymer chains, and compute a dimensionless quantity called instantaneous shape ratio (Rs ), as Rs = Ree 2 /Rg 2 , where Ree is end-to-end distance and Rg is radius of gyration...
April 12, 2024: Biophysical Journal
#11
REVIEW
Oliver L Rees, Peter Wheen, Lisa J Anderson
This review provides a contemporary overview of HF management and highlights the key studies which have informed recent European HF guidelines.
September 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
#12
REVIEW
Matthew J Rees, Shaji Kumar
Multiple myeloma (MM) exhibits significant heterogeneity in its presentation, genetics, and treatment response. Despite therapeutic advances, some patients continue to relapse early (ER, <18-months) and rapidly cycle through therapies. Myriad prognostic factors have been identified and incorporated into risk stratification models; however, these produce discordant, often three-tiered outputs that fail to identify many patients destined for ER. Treatment strategies are increasingly focused on disease biology and trials enriched for high-risk (HR)MM, but consensus on the minimum required testing and a succinct, specific, and clinically meaningful definition for HRMM remains elusive...
April 13, 2024: American Journal of Hematology
#13
REVIEW
Angela M Ricci, Rebecca T Emeny, Pamela J Bagley, Heather B Blunt, Mary E Butow, Alexandra Morgan, Jennifer A Alford-Teaster, Linda Titus, Raymond R Walston, Judy R Rees
PURPOSE: To review the childhood risk factors for pediatric cancer (diagnosis before age 20). METHODS: We conducted literature searches using Ovid Medline and Scopus to find primary research studies, review articles, and meta-analyses published from 2014 to 3 March 2021. RESULTS: Strong evidence indicates that an array of genetic and epigenetic phenomena, structural birth defects, and chromosomal anomalies are associated with an increased risk of various childhood cancers...
March 27, 2024: Cancers
#14
JOURNAL ARTICLE
Shadman Aziz, Kate Lachowycz, Rob Major, Paul Rees, Jon Barratt
Outcomes after out-of-hospital cardiac arrest (OHCA) remain poor in the UK. In order to increase the chances of successful resuscitation, international society guidelines on cardiopulmonary resuscitation quality have recommended titration of chest compression parameters and vasopressor administration to arterial diastolic blood pressure if invasive catheters are in situ at the time of cardiac arrest. However, prehospital initiation of arterial and central venous catheterisation is seldom undertaken due to the risks and significant technical challenges in the context of ongoing resuscitation in this environment...
April 12, 2024: Journal of Vascular Access
#15
REVIEW
Diane Kelly, Jonathan Barrett, Gabrielle Brand, Michelle Leech, Charlotte Rees
BACKGROUND: Delivering intensive care therapies concordant with patients' values and preferences is considered gold standard care. To achieve this, healthcare professionals must better understand decision-making processes and factors influencing them. AIM: The aim of this study was to explore factors influencing decision-making processes about implementing and limiting intensive care therapies. DESIGN: Systematic integrative review, synthesising quantitative, qualitative, and mixed-methods studies...
April 11, 2024: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
#16
JOURNAL ARTICLE
Iris T Lee, John Rees, Shakira King, Anne Kim, Tess Cherlin, Stefanie Hinkle, Sunni L Mumford, Anuja Dokras
CONTEXT: Patients with PCOS are at high risk of depression, anxiety, and metabolic syndrome (MetSyn), a key predictor of cardiovascular disease. The impact of depression and/or anxiety on MetSyn is unknown in this population. OBJECTIVE: To compare the risk of developing MetSyn in patients with PCOS with and without a history of depression and/or anxiety. DESIGN: Retrospective longitudinal cohort study (2008-2022) with median follow-up of 7 years...
April 13, 2024: Journal of Clinical Endocrinology and Metabolism
#17
JOURNAL ARTICLE
Xiao-Rui Liu, Wen-Shen Liu, Miaoyue Zhang, Chao Jin, Keng-Bo Ding, Alan J M Baker, Rong-Liang Qiu, Ye-Tao Tang, Shi-Zhong Wang
Ion-adsorption rare earth element (REE) deposits distributed in the subtropics provide a rich global source of REEs, but in situ injection of REEs extractant into the mine can result in leachate being leaked into the surrounding groundwater systems. Due to the lack of understanding of REE speciation distribution, particularly colloidal characteristics in a mining area, the risks of REEs migration caused by in situ leaching of ion-adsorption REE deposits has not been concerned. Here, ultrafiltration and asymmetric flow field-flow fractionation coupled with inductively coupled plasma mass spectrometry (AF4-ICP-MS) were integrated to characterize the size and composition of REEs in leachate and groundwater from mining catchments in South China...
April 7, 2024: Water Research
#18
JOURNAL ARTICLE
Guanfeng Lin, Guilong Wang, Yongzhi Xiong, Simin Li, Rongyuan Jiang, Beili Lu, Biao Huang, Haijiao Xie
Transition-metal-oxide@heteroatom doped porous carbon composites have attracted considerable research interest because of their large theoretical adsorption capacity, excellent electrical conductivity and well-developed pore structure. Herein, Mn3 O4 -loaded phosphorus-doped porous carbon composites (Mn3 O4 @PC-900) were designed and fabricated for the electrosorption of La3+ in aqueous solutions. Due to the synergistic effect between Mn3 O4 and PC-900, and the active sites provided by Mn-O-Mn, C/PO, C-P-O and Mn-OH, Mn3 O4 @PC-900 exhibits high electrosorption performance...
April 11, 2024: Journal of Environmental Management
#19
JOURNAL ARTICLE
E D Carter, D E Stewart, E E Rees, J E Bezuidenhoudt, V Ng, S Lynes, J C Desenclos, T Pyone, A C K Lee
OBJECTIVES: Currently, there is no comprehensive picture of the global surveillance landscape. This survey examines the current state of surveillance systems, levels of integration, barriers and opportunities for the integration of surveillance systems at the country level, and the role of national public health institutes (NPHIs). STUDY DESIGN: This was a cross-sectional survey of NPHIs. METHODS: A web-based survey questionnaire was disseminated to 110 NPHIs in 95 countries between July and August 2022...
April 10, 2024: Public Health
#20
JOURNAL ARTICLE
Catherine Riou, Jinal N Bhiman, Yashica Ganga, Shobna Sawry, Frances Ayres, Richard Baguma, Sashkia R Balla, Ntombi Benede, Mallory Bernstein, Asiphe S Besethi, Sandile Cele, Carol Crowther, Mrinmayee Dhar, Sohair Geyer, Katherine Gill, Alba Grifoni, Tandile Hermanus, Haajira Kaldine, Roanne S Keeton, Prudence Kgagudi, Khadija Khan, Erica Lazarus, Jean Le Roux, Gila Lustig, Mashudu Madzivhandila, Siyabulela F J Magugu, Zanele Makhado, Nelia P Manamela, Qiniso Mkhize, Paballo Mosala, Thopisang P Motlou, Hygon Mutavhatsindi, Nonkululeko B Mzindle, Anusha Nana, Rofhiwa Nesamari, Amkele Ngomti, Anathi A Nkayi, Thandeka P Nkosi, Millicent A Omondi, Ravindre Panchia, Faeezah Patel, Alessandro Sette, Upasna Singh, Strauss van Graan, Elizabeth M Venter, Avril Walters, Thandeka Moyo-Gwete, Simone I Richardson, Nigel Garrett, Helen Rees, Linda-Gail Bekker, Glenda Gray, Wendy A Burgers, Alex Sigal, Penny L Moore, Lee Fairlie
We report the safety and immunogenicity of fractional and full dose Ad26.COV2.S and BNT162b2 in an open label phase 2 trial of participants previously vaccinated with a single dose of Ad26.COV2.S, with 91.4% showing evidence of previous SARS-CoV-2 infection. A total of 286 adults (with or without HIV) were enrolled >4 months after an Ad26.COV2.S prime and randomized 1:1:1:1 to receive either a full or half-dose booster of Ad26.COV2.S or BNT162b2 vaccine. B cell responses (binding, neutralization and antibody dependent cellular cytotoxicity-ADCC), and spike-specific T-cell responses were evaluated at baseline, 2, 12 and 24 weeks post-boost...
2024: PLOS Glob Public Health
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
