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German Baeza-Cruz, Gustavo Peniche-Otero, Mónica E Alva-Esqueda, Mariana Naranjo-Muedano, Noé Soria-Suárez, Héctor J Morales-Flores
OBJETIVOS: Describir los costos y el impacto económico de la atención de pacientes diagnosticados con hipercolesterolemia en México en el año 2016. METODOLOGíA: Se desarrolla una evaluación económica del tipo análisis de costo de la enfermedad donde se cuantifican los recursos médicos utilizados para el tratamiento de la hipercolesterolemia así como para sus complicaciones. Los costos de los recursos médicos utilizados son obtenidos de los costos unitarios por nivel de atención del Instituto Mexicano del Seguro Social (IMSS) así como de las licitaciones publicadas en el portal de compras del IMSS...
April 20, 2018: Value in Health Regional Issues
Minju Joy, Kajal Chakraborty
The estuarine Corbiculid bivalve black clam, Villorita cyprinoides collected from the Southwestern coastline regions of Arabian Sea are significant resources of nutritional and bioactive pluralities. The purification of ethyl acetate:methanol (EtOAc:MeOH) extract of V. cyprinoides characterized a previously undisclosed specialized abeo-pregnane-type sterol derivative 19 (10→5) abeo-20-methyl-pregn-10-en-3β-yl-hex-(3'E)-enoate (1) along with two cholestenols (22E),(241 E)-241 ,242 -dihomocholesta-5,22,241 -trien-3β-ol (2) and (22E)-241 -homocholesta-5,22-dien-(3β,241 β)-diol (3)...
April 20, 2018: Steroids
Marek Bužga, Petra Marešová, Karin Petřeková, Pavol Holéczy, Kamil Kuča
OBJECTIVE: Approximately 25% of the Czech population is currently obese. Obesity rates are expected to increase in the future. Obesity not only raises the risk of health complications for individuals, but increasing rates also represent a significant and steadily growing economic burden for healthcare systems and society as a whole. The aim of this study was to evaluate the therapeutic efficacy of three methods of bariatric surgery: laparoscopic greater curve plication (LGCP), laparoscopic sleeve gastrectomy (LSG), and Roux-en-Y gastric bypass (RYBG) in patients with type 2 diabetes mellitus (DM)...
March 2018: Central European Journal of Public Health
Eric J Siskind, Leo I Amodu, Sonia Pinto, Meredith Akerman, Johann Jonsson, Ernesto P Molmenti, Jorge Ortiz
OBJECTIVES: The method for drainage of exocrine secretions in pancreas transplantation remains a matter of debate. Different methods have evolved over time. Most data on these methods are from single-center studies with small sample sizes. Larger studies have yielded conflicting results. METHODS: Data from the United Network for Organ Sharing database on all adult subjects who received pancreas and kidney-pancreas transplants between 1996 and 2012 were analyzed (n = 19,934)...
April 19, 2018: Pancreas
Yongfei Li, Lei Song, Bang Wang, Jianbo He, Yulin Li, Zhaoxiang Deng, Chengde Mao
pH-responsivity has been widely pursued in dynamic DNA nanotechnology, due to its great potential in biosensing, controlled release and nanomachinery. Previously developed pH-triggering systems mostly depend on specific designs of DNA sequences. However, sequence-independent regulation could provide a more general tool to achieve pH-responsive DNA assembly, which has yet to be developed. Herein, we propose a mechanism for dynamic DNA assembly by utilizing ethylenediamine (EN) as a reversibly chargeable (via protonation) cation to overcome electrostatic repulsions...
April 23, 2018: Angewandte Chemie
Kajal Chakraborty, Minju Joy
Chemical investigations of the ethyl acetate-methanol (EtOAc-MeOH) extract of the selected mollusks from the south-west coast of Arabian Sea led to the isolation of methyl-3-(26-phenylacetyloxy)-icosahydro-19-hydroxy-4,4,20-trimethylpicene-23-carboxylate (1) and methyl-3-(26-phenylacetyloxy)-icosahydro-1,19-dihydroxy-4,4,20-trimethylpicene-23-carboxylate (2) from Crassostrea madrasensis, whereas cholesta-5-en-3β-yl-(32-methyl-(30-((E)-34-amino-36-ethyl-39-oxohept-36-enyl)-pentanedioate (3) and 7-ethyl-9-vinyl-octahydroazuleno [1,8-bc]pyran-3,12-dione (4) were isolated from Amphioctopus marginatus...
April 23, 2018: Natural Product Research
Juan García de la Concepción, Martín Ávalos, Pedro Cintas, José L Jiménez, Mark E Light
This paper describes a mechanistic study, with the interplay of experiment and theory, on the cycloadditions of a bicyclic mesoionic 1,3-dipole versus a series of representative symmetrical (1-phenyl-1H-pyrrole-2,5-dione and dimethyl maleate) and asymmetrical [(E)-(2-nitrovinyl)benzene, acrylonitrile, and but-3-en-2-one] olefinic dipolarophiles. These results allow a comparative analysis with monocyclic dipoles and open further avenues to structurally diversified heteroatom-rich rings. The unichiral version of the bicyclic dipole leads to adducts containing up to five chiral centers, whose formation proceeds with high levels of facial stereoinduction in reactions involving bulky dipolarophiles...
April 23, 2018: Organic & Biomolecular Chemistry
En-Tzu Liao, Yi-Wen Lin, Chun-Ping Huang, Nou-Ying Tang, Ching-Liang Hsieh
Epilepsy is a common clinical syndrome with recurrent neuronal discharges in the temporal lobe, cerebral cortex, and hippocampus. Clinical antiepileptic medicines are often ineffective or of little benefit in 30% of epileptic patients and usually cause severe side effects. Emerging evidence indicates the crucial role of inflammatory mediators in epilepsy. The current study investigates the role of toll-like receptor 4 (TLR4) and its underlying mechanisms in kainic acid- (KA-) induced epileptic seizures in rats...
2018: BioMed Research International
Hai-Feng Liu, Cheng Luo, Wu Song, Haitao Shen, Guoliang Li, Zhi-Gang He, Wen-Gang Chen, Yan-Yan Cao, Fang Huang, Shou-Wu Tang, Ping Hong, En-Feng Zhao, Jianbo Zhu, Dajun He, Shaoming Wang, Guang-Ying Huo, Hailiang Liu
The existence of only natural brown and green cotton fibers (BCF and GCF, respectively), as well as poor fiber quality, limits the use of naturally colored cotton ( Gossypium hirsutum L.). A better understanding of fiber pigment regulation is needed to surmount these obstacles. In this work, transcriptome analysis and quantitative reverse transcription PCR revealed that 13 and 9 phenylpropanoid (metabolic) pathway genes were enriched during pigment synthesis, while the differential expression of phenylpropanoid (metabolic) and flavonoid metabolic pathway genes occurred among BCF, GCF, and white cotton fibers (WCF)...
2018: PeerJ
Sami Akbulut, Mehmet Yilmaz
Hydatid cyst disease caused by E. granulosus is a zoonotic disease that may involve many body tissues and organs, mainly liver. Adrenal glands are rarely involved even in regions where hydatid cyst disease is endemic. A limited number of studies have been reported on adrenal gland involvement by hydatid cyst disease. Herein, we aimed to report a recurrent case of adrenal hydatid cyst that was misdiagnosed as a hepatic hydatid cyst. A 16-year-old boy with a history of partial cyst excision and evacuation for perforated adrenal hydatid cyst disease three years ago presented to our outpatient clinic with nonspecific abdominal pain...
2018: Case Reports in Surgery
A Bhat, L J Layfield, S O Tewari, A H Gaballah, R Davis, Z Wu
Solitary fibrous tumors are primary mesenchymal tumors, which may occur in any part of the body. Overall, these tumors are considered to have intermediate malignant potential with 5- and 10-year metastasis-free and overall disease-specific survival rates of 74% and 55%, and 89% and 73%, respectively (Demicco et al, 2012). Herein we present an unusual case of solitary fibrous tumors involving the ischioanal fossa in a 19-year-old woman with radiologic-pathologic correlation. This case was complicated by extensive tumor vascularity and was thus managed with preoperative embolization followed by en bloc surgical resection...
April 2018: Radiology Case Reports
Zhe Yu, Fan Song, Yu-Chen Jin, Wei-Min Zhang, Ya Zhang, En-Jun Liu, Dan Zhou, Lin-Lin Bi, Qian Yang, Hua Li, Bang-Le Zhang, Si-Wang Wang
Gallic acid (GA) is a polyphenolic natural product widely distributed in food, beverage, and traditional Chinese herbs with beneficial effects on the cardiovascular system. In this research, a comparative study was conducted to investigate the possible difference of pharmacokinetic process in normal and isoproterenol-induced myocardial infarcted rats after oral administration of GA monohydrate with the dose of 50 and 100 mg/kg, respectively. Quantification of GA in rat plasma was achieved by using a simple and rapid high-performance liquid chromatographic method...
2018: Frontiers in Pharmacology
Natsuki Monai, Reiko Tanabu, Takayuki Gonome, Katsunori Yokoi, Satoshi Urushidate, Satoko Morohashi, Hideaki Hirai, Akira Kurose, Mitsuru Nakazawa
Purpose: To report a case of recurrent conjunctival papillary sebaceous carcinoma that was successfully treated by a combination of surgical resection, intraoperative topical mitomycin C application, and cryotherapy. Observations: A woman in her 80s developed a yellowish papillary tumor pedunculated from the surface of the upper palpebral tarsal conjunctiva in her left eye. She was histopathologically diagnosed as having sebaceous carcinoma by an excisional biopsy...
January 2018: Case Reports in Ophthalmology
Vojtech Vyklicky, Barbora Krausova, Jiri Cerny, Marek Ladislav, Tereza Smejkalova, Bohdan Kysilov, Miloslav Korinek, Sarka Danacikova, Martin Horak, Hana Chodounska, Eva Kudova, Ladislav Vyklicky
N-methyl-D-aspartate receptors (NMDARs), glutamate-gated ion channels, mediate signaling at the majority of excitatory synapses in the nervous system. Recent sequencing data for neurological and psychiatric patients have indicated numerous mutations in genes encoding for NMDAR subunits. Here, we present surface expression, functional, and pharmacological analysis of 11 de novo missense mutations of the human hGluN2B subunit (P553L; V558I; W607C; N615I; V618G; S628F; E657G; G820E; G820A; M824R; L825V) located in the pre-M1, M1, M2, M3, and M4 membrane regions...
2018: Frontiers in Molecular Neuroscience
Robert Brett McQueen, Marc D Breton, Joyce Craig, Hayden Holmes, Melanie D Whittington, Markus A Ott, Jonathan D Campbell
OBJECTIVE: The objective was to model clinical and economic outcomes of self-monitoring blood glucose (SMBG) devices with varying error ranges and strip prices for type 1 and insulin-treated type 2 diabetes patients in England. METHODS: We programmed a simulation model that included separate risk and complication estimates by type of diabetes and evidence from in silico modeling validated by the Food and Drug Administration. Changes in SMBG error were associated with changes in hemoglobin A1c (HbA1c) and separately, changes in hypoglycemia...
April 1, 2018: Journal of Diabetes Science and Technology
Alia Hadefi, Vincent Huberty, Arnaud Lemmers, Marianna Arvanitakis, David Maggs, Guido Costamagna, Jacques Devière
Type 2 diabetes is a pandemic disease with an incidence that has risen steadily over recent decades. Experimental evidence in animals has demonstrated that intestinal bypass surgery of the upper small intestine, particularly the duodenum, has an important role in glucose homoeostasis. Furthermore, Roux-en-Y bypass performed as bariatric surgery has shown to correct hyperglycaemia from the first postoperative days in obese diabetic patients. Therefore, on the basis of these considerations, duodenal mucosal resurfacing was studied in type 2 diabetes patients as a minimally invasive procedure that could offer an alternative treatment for these patients...
April 20, 2018: Digestive Diseases
Lin Ma, Ji-Chong Xu, Shuo Yan, Hao Feng, Hong-Jie Han, Hua-Qiao Tan, Chun Fang, Hong-En Huang
OBJECTIVE: To report the clinical results and initial clinical experience of endovascular isolation with the Willis covered stent for carotid siphon aneurysms. METHODS: Between November 2013 and December 2016, a total of 57 patients who presented with carotid siphon aneurysms were treated with the Willis covered stent. Results of the procedures, technical events, and complications were recorded. Clinical and imaging follow-ups were performed at 3 months following the endovascular procedures...
April 21, 2018: Journal of Neurointerventional Surgery
S Papamarkou, D Christopoulos, P E Tsakiridis, G Bartzas, K Tsakalakis
The present investigation focuses on the utilization of medical wastes incineration bottom ash (MBA), vitrified with soda lime recycled glass (SLRG), as an alternative raw material in cement clinkerization. Bottom ash is recovered from the bottom of the medical wastes incineration chamber, after being cooled down through quenching. It corresponds to 10-15 wt% of the initial medical wastes weight and since it has been classified in the category of hazardous wastes, its safe management has become a major environmental concern worldwide...
April 19, 2018: Science of the Total Environment
Marta M Marzi, Miryam S Pires, Nora B Quaglia
OBJECTIVES: To perform a list agreed by Argentinean experts and adapted to the local context containing potentially inappropriate (PI) medications in old people (OP) usingthe Delphi consensus technique optimized for this subject. METHODS: A preliminary list of potentially inappropriate medications (PIM) was drawn up based on foreign PIM lists and a selective search in the scientific literature. The iterative Delphi process was used to submit the active pharmaceutical ingredients (APIs) of the preliminary PIM list to the panel of Argentinean experts...
April 18, 2018: Value in Health Regional Issues
Hui-Min Yang, Zhi-Qi Yin, Meng-Ge Zhao, Cui-Hua Jiang, Jian Zhang, Ke Pan
Six undescribed pentacyclic triterpenoids including four triterpenoid aglycones, 1β,2a,3β,23-tetrahydroxyurs-12-en-28-ursolic acid, 2a,3a,6β,19α,23-pentahydroxyurs-12-en-28-ursolic acid, 2α,3α,20β,23-tetrahydroxyurs-12-en-28-ursolic acid and 1β,2a,3β,23-tetrahydroxyurs-12,20(30)-dien-28-ursolic acid, and two triterpenoid glucosides, 2a,3a,23-trihydroxy-12,20(30)-dien-28-ursolic acid 28-O-β-d-glucopyranoside and 1-oxo-3β,23-dihydroxyolean-12-en-28-oic acid 28-O-β-d-xylopyranoside, along with 5 known triterpenoids were isolated from a CH3 Cl-soluble extract of the leaves of Cyclocarya paliurus...
April 18, 2018: Phytochemistry
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