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https://www.readbyqxmd.com/read/29444281/surgical-management-of-esophageal-sarcoma-a-multicenter-european-experience
#1
D Mege, L Depypere, G Piessen, A E Slaman, B P L Wijnhoven, A Hölscher, M Nilsson, M I van Berge Henegouwen, J J B van Lanschot, W Schroeder, P A Thomas, P Nafteux, X B D'Journo
Esophageal sarcomas are rare and evidence in literature is scarce making their management difficult. The objective is to report surgical and oncological outcomes of esophageal sarcoma in a large multicenter European cohort. This is a retrospective multicenter study including all patients who underwent en-bloc esophagectomy for esophageal sarcoma in seven European tertiary referral centers between 1987 and 2016. The main outcomes and measures are pathological results, early and long-term outcomes. Among 10,936 esophageal resections for cancer, 21 (0...
February 9, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29444205/ssbio-a-python-framework-for-structural-systems-biology
#2
Nathan Mih, Elizabeth Brunk, Ke Chen, Edward Catoiu, Anand Sastry, Erol Kavvas, Jonathan M Monk, Zhen Zhang, Bernhard O Palsson, Alfonso Valencia
Summary: Working with protein structures at the genome-scale has been challenging in a variety of ways. Here, we present ssbio, a Python package that provides a framework to easily work with structural information in the context of genome-scale network reconstructions, which can contain thousands of individual proteins. The ssbio package provides an automated pipeline to construct high quality genomescale models with protein structures (GEM-PROs), wrappers to popular third-party programs to compute associated protein properties, and methods to visualize and annotate structures directly in Jupyter notebooks, thus lowering the barrier of linking 3D structural data with established systems workflows...
February 12, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29443912/influence-of-scanning-strategies-on-processing-of-aluminum-alloy-en-aw-2618-using-selective-laser-melting
#3
Daniel Koutny, David Palousek, Libor Pantelejev, Christian Hoeller, Rudolf Pichler, Lukas Tesicky, Jozef Kaiser
This paper deals with various selective laser melting (SLM) processing strategies for aluminum 2618 powder in order to get material densities and properties close to conventionally-produced, high-strength 2618 alloy. To evaluate the influence of laser scanning strategies on the resulting porosity and mechanical properties a row of experiments was done. Three types of samples were used: single-track welds, bulk samples and samples for tensile testing. Single-track welds were used to find the appropriate processing parameters for achieving continuous and well-shaped welds...
February 14, 2018: Materials
https://www.readbyqxmd.com/read/29442623/structural-characterization-and-analysis-of-human-immunodeficiency-virus-encapsulating-quantum-dots
#4
Wen Yin, Wei Li, Qin Li, Chong Qin, Zhiping Zhang, Xiaowei Zhang, Xian-En Zhang, Zongqiang Cui
Virus internal labeling by inorganic nanoparticle is a suitable technique for single virus imaging. However, it is unknown that the effect of the internal inorganic nanoparticle on morphology and structure of viral core in mature enveloped Human immunodeficiency virus 1 (HIV-1). Also, the analysis of intact HIV-1 particles and virus-inorganic nanoparticle hybrids is almost impossible with conventional negative staining because HIV-1 is inherently fragile and unstable. Herein, we carried out morphological and structural analysis of a newly constructed quantum dot (QD)-encapsulated infectious HIV-1 particle by using an optimized procedure for the electron microscopic analysis of negatively stained HIV-1 particles...
July 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442214/en-masse-lentiviral-gene-delivery-to-mouse-fertilized-eggs-via-laser-perforation-of-zona-pellucida
#5
Negin P Martin, Page Myers, Eugenia Goulding, Shih-Heng Chen, Mitzie Walker, Thomas M Porter, Lucas Van Gorder, Amanda Mathew, Artiom Gruzdev, Charles Romeo
Lentiviruses are highly efficient vehicles for delivering genes into cells. They readily transduce primary and immortalized cells in vivo and in vitro. Genes delivered by lentiviruses are incorporated and replicated as part of their host genome and therefore offer a powerful tool for creation of stable cell lines and transgenic animals. However, the zona pellucida surrounding the fertilized eggs acts as a barrier and hinders lentiviral transduction of embryos. Here, we utilize a laser, typically used to perforate the zona pellucida for in vitro fertilization, to permeabilize the zona for lentiviral gene delivery...
February 13, 2018: Transgenic Research
https://www.readbyqxmd.com/read/29440925/chronic-back-pain-cured-by-low-dose-levodopa-is-it-a-variant-of-restless-legs-syndrome
#6
Zhi-Fen Zeng, Yan-Ran Liang, Ying Chen, Xiu-Na Jing, Su-Dan Peng, En-Xiang Tao
Chronic back pain is one of the most common reasons for missed work and visits to the doctor. This report presents 2 interesting cases of chronic back pain that were effectively relieved by low-dose levodopa. These 2 patients showed no sign of anatomical problem of the spine or relative structures, but the discomforts on the back manifested some characteristics resembling those in restless legs syndrome (RLS), and one of them actually developed RLS after many years of back problem. We believe that this type of chronic back pain might be a variant of RLS, which we would like to call "restless back", and it can be effectively treated by dopaminergic drugs...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29440239/follicular-dendritic-cell-sarcoma-of-the-duodenum-an-extremely-rare-entity
#7
Atakelet Ferede, Roisin O'Connor, Anthony Stafford, Niall Swan
Extranodal follicular dendritic cell sarcoma (FDCS) is a very rare tumour, only reported in case reports and case series. It poses diagnostic and management challenge both to the clinician and pathologist. We present such a rare case of duodenal FDCS in a 56-year-old woman who was recently managed in our institution. Repeated pre surgical biopsies were non-diagnostic and the final diagnosis was made only after surgical excision of the tumour and with the help of histopathological and immunohistochemical studies...
February 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29437904/a-computational-study-for-rational-hiv-1-non-nucleoside-reverse-transcriptase-inhibitor-selection-and-discovery-of-novel-allosteric-pockets-for-inhibitor-design
#8
Ron Zhi-Hui Chiang, Samuel Ken-En Gan, Chinh Tran-To Su
HIV drug resistant mutations that render the current Highly Active Anti-Retroviral Therapy cocktail drugs ineffective are increasingly reported. To study the mechanisms of these mutations in conferring drug resistance, we computationally analyzed fourteen Reverse Transcriptase (RT) structures of HIV-1 on the following parameters: drug-binding pocket volume, allosteric effects caused by the mutations, and structural thermal stability. We constructed structural correlation-based networks of the mutant RT-drug complexes and the analyses support the use of Efavirenz as the first-line drug, given that cross-resistance is least likely to develop from Efavirenz-resistant mutations...
February 5, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29437375/tailoring-polyelectrolyte-architecture-to-promote-cell-growth-and-inhibit-bacteria-adhesion
#9
Shanshan Guo, Min Yi Kwek, Zi Qian Toh, Dicky Pranantyo, En-Tang Kang, Xian Jun Loh, Xiaoying Zhu, Dominik Jańczewski, Koon-Gee Neoh
An important challenge facing the application of implanted biomaterials for tissue engineering is the need to facilitate desirable tissue interactions with the implant while simultaneously inhibiting bacterial colonization, which can lead to implant-associated infection. In this study, we explore the relevance of physical parameters of polyelectrolyte multilayers, surface charge, wettability and stiffness, in tissue cell/surface and bacteria/surface interactions, and investigate the tuning of the multilayer architecture to differentially control such interactions...
February 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29437275/intersection-of-endocytic-and-exocytic-systems-in-toxoplasma-gondii
#10
Olivia L McGovern, Yolanda Rivera-Cuevas, Geetha Kannan, Andrew Narwold, Vern B Carruthers
Host cytosolic proteins are endocytosed by Toxoplasma gondii and degraded in its lysosome-like compartment, the VAC, but the dynamics and route of endocytic trafficking remain undefined. Conserved endocytic components and plant-like features suggest T. gondii endocytic trafficking involves transit through early and late endosome-like compartments (ELCs) and potentially the trans-Golgi network (TGN) as in plants. However, exocytic trafficking to regulated secretory organelles, micronemes and rhoptries, also proceeds through ELCs and requires classical endocytic components including a dynamin-related protein, DrpB...
February 13, 2018: Traffic
https://www.readbyqxmd.com/read/29437274/hybrid-indicators-for-fast-and-sensitive-voltage-imaging
#11
Yongxian Xu, Luxin Peng, Sicong Wang, Anqi Wang, Ruirui Ma, Ying Zhou, Jiahe Yang, De-En Sun, Wei Lin, Xing Chen, Peng Zou
Membrane voltage is an important biophysical signal that underlies intercellular electrical communications. In this study, we present a novel fluorescent voltage indicator that enables the investigation of electrical signaling at high spatial resolution. Our method is built upon the site-specific modification of microbial rhodopsin proteins with organic fluorophores, resulting in a hybrid indicator scaffold that represents one of the most sensitive and fastest orange-colored voltage indicators developed to date...
February 13, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29436001/effects-of-pulsatile-blood-flow-on-oxygenator-performance
#12
Lotte Schraven, Andreas Kaesler, Christian Flege, Rüdger Kopp, Thomas Schmitz-Rode, Ulrich Steinseifer, Jutta Arens
Extracorporeal membrane oxygenation (ECMO) is mainly used for the therapy of acute respiratory distress syndrome and chronic obstructive lung disease. In the last years, the development of these systems underwent huge steps in optimization, but there are still problems with thrombus formation, clogging, and thus insufficient gas exchange. One idea of ECMO optimization is a pulsatile blood flow through the oxygenator, but this is still a controversy discussion. Analyzing available publications, it was not possible to identify a general statement about the effect of pulsatile blood flow on the gas exchange performance...
February 13, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29435819/expanding-role-of-third-space-endoscopy-in-the-management-of-esophageal-diseases
#13
REVIEW
Dennis Yang, Peter V Draganov
OPINION STATEMENT: "Third space" endoscopy, also commonly referred as submucosal endoscopy, is founded on the principle that the deeper layers of the gastrointestinal (GI) tract can be accessed by tunneling in the submucosal space without compromising the integrity of the overlying mucosa. Peroral endoscopic myotomy (POEM), endoscopic submucosal dissection (ESD), and submucosal tunneling endoscopic resection (STER) are innovative techniques within the field of third space endoscopy in the management of esophageal disorders...
February 12, 2018: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29435811/comparative-outcomes-of-bariatric-surgery-in-patients-with-impaired-mobility-and-ambulatory-population
#14
Gautam Sharma, Zubaidah Nor-Hanipah, Ivy N Haskins, Suriya Punchai, Andrew T Strong, Chao Tu, John H Rodriguez, Phillip R Schauer, Matthew Kroh
PURPOSE: This study aims to characterize complications, metabolic improvement, and change in ambulation status for patients with impaired mobility undergoing bariatric surgery. MATERIAL AND METHODS: Individuals undergoing primary sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) from February 2008 to December 2015 were included. Impaired mobility (WC) was defined as using a wheelchair or motorized scooter for at least part of a typical day. The WC group was propensity score matched to ambulatory patients (1:5 ratio)...
February 12, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29435781/fast-and-accurate-quantitative-organic-acid-analysis-with-lc-qtof-ms-facilitates-screening-of-patients-for-inborn-errors-of-metabolism
#15
Irene M L W Körver-Keularts, Ping Wang, Huub W A H Waterval, Leo A J Kluijtmans, Ron A Wevers, Claus-Dieter Langhans, Camilla Scott, Daphna D J Habets, Jörgen Bierau
Since organic acid analysis in urine with gaschromatography-mass spectrometry (GC-MS) is a time-consuming technique, we developed a new liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF/MS) method to replace the classical analysis for diagnosis of inborn errors of metabolism (IEM). Sample preparation is simple and experimental time short. Targeted mass extraction and automatic calculation of z-scores generated profiles characteristic for the IEMs in our panel consisting of 71 biomarkers for defects in amino acids, neurotransmitters, fatty acids, purine, and pyrimidine metabolism as well as other disorders...
February 12, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29435755/surgical-management-of-gastroesophageal-reflux-disease-in-patients-with-systemic-sclerosis
#16
Jingliang Yan, Andrew T Strong, Gautam Sharma, Scott Gabbard, Prashanti Thota, John Rodriguez, Matthew Kroh
BACKGROUND: Systemic sclerosis (scleroderma) is frequently associated with both gastroesophageal reflux disease (GERD) and simultaneous esophageal dysmotility. Anti-reflux procedures in this patient population must account for the existing physiology of each patient and likely disease progression. We aim to compare perioperative and intermediate outcomes of fundoplication versus gastric bypass for the treatment of GERD. METHODS: After IRB approval, patients with systemic sclerosis undergoing fundoplication or gastric bypass for the treatment of GERD from 2004 to 2016 were identified...
February 12, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29435660/indications-for-total-esophagogastric-dissociation-in-children-with-gastroesophageal-reflux-disease
#17
REVIEW
Yujiro Tanaka, Takahisa Tainaka, Hiroo Uchida
Total esophagogastric dissociation (TED) is used to treat gastroesophageal reflux (GER) after failed fundoplication in neurologically impaired patients. It is now performed for some otherwise healthy patients with severe GER. In this procedure, the gastrointestinal tract is reconstructed in a non-physiological way with a Roux-en-Y esophagojejunal anastomosis and jejuno-jejunostomy. Although TED eliminates almost all GER, some patients experience late complications. In this review, we investigated the long-term outcomes after TED to determine the best indications...
February 12, 2018: Surgery Today
https://www.readbyqxmd.com/read/29435627/wide-surgical-margin-improves-the-outcome-for-patients-with-gastrointestinal-stromal-tumors-gists
#18
Jan Åhlén, Fredrik Karlsson, Johan Wejde, Inga-Lena Nilsson, Catharina Larsson, Robert Bränström
BACKGROUND: Surgical resection is still the main treatment for gastrointestinal stromal tumor (GIST), and R0 excision, regardless of surgical margins, is considered sufficient. METHODS: A cohort of 79 consecutive GIST cases treated at the Karolinska University Hospital, who were without metastasis at diagnosis and who had not received any pre-or postoperative treatment with tyrosine kinase inhibitors, was included. Surgical margins were evaluated at the time of surgery and classified as wide, marginal or intralesional...
February 12, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29435272/optimal-antithrombotic-therapy-in-patients-with-atrial-fibrillation-following-percutaneous-coronary-intervention-a-systemic-review-and-meta-analysis
#19
Jing-Xiu Li, Yang Li, Shu-Jun Yan, Bai-He Han, Zhao-Yan Song, Wei Song, Shi-Hao Liu, Ji-Wei Guo, Shuo Yin, Ye-Ping Chen, De-Jun Xia, Xin Li, Xue-Qi Li, En-Ze Jin
A challenge for antithrombotic treatment is patients who present with atrial fibrillation (AF) and acute coronary syndrome, particularly in patients who have undergone coronary percutaneous intervention with stenting (PCIS). In the present study, a total of nine observational trials published prior to July 2017 that investigated the effects of dual antiplatelet therapy (DAPT; aspirin + clopidogrel) and triple oral antithrombotic therapy (TOAT; DAPT + warfarin) among patients with AF concurrent to PCIS were collected from the Medline, Cochrane and Embase databases and conference proceedings of cardiology, gastroenterology and neurology meetings...
February 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29434747/microrna-30a-suppresses-non-small-cell-lung-cancer-by-targeting-myb-related-protein-b
#20
Guo-Jun Geng, Ying-Tao Yang, Jie Jiang, Xiu-Yi Yu, Xian-En Fa
Non-small-cell lung cancer (NSCLC) is one of the leading causes of cancer mortality worldwide. A growing body of evidence indicates that microRNA (miR) have important and diverse roles in the proliferation, apoptosis and metastasis of human cancer cells. In the present study, the molecular regulation mechanism of miR-30a and its potential target, Myb-related protein B (MYBL2) was investigated in NSCLC. Reverse transcription-quantitative polymerase chain reaction results showed that miR-30a was significantly downregulated in NSCLC tissues compared with adjacent normal tissues (P<0...
February 2018: Experimental and Therapeutic Medicine
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