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Gulay Erdogan Kayhan, Mukadder Sanli, Ulku Ozgul, Ramazan Kirteke, Saim Yologlu
STUDY OBJECTIVE: Multimodal analgesic strategies are recommended to decrease opioid requirements and opioid-induced respiratory complications in patients undergoing laparoscopic bariatric surgery. Recent studies have demonstrated that intravenous ibuprofen decreases opioid consumption compared with placebo. The primary aim of this study was to compare the effect of intravenous ibuprofen and intravenous acetaminophen on opioid consumption. We also aimed to compare postoperative pain levels and side effects of the drugs...
June 20, 2018: Journal of Clinical Anesthesia
Yun Qian, Qixin Han, Xiaotian Zhao, Jialin Song, Yuan Cheng, Zhiwei Fang, Yuanming Ouyang, Wei-En Yuan, Cunyi Fan
Peripheral nerve defect is a common and severe kind of injury in traumatic accidents. Melatonin can improve peripheral nerve recovery by inhibiting oxidative stress and inflammation after traumatic insults. In addition, it triggers autophagy pathways to increase regenerated nerve proliferation and to reduce apoptosis. In this study, we fabricated a melatonin-controlled-release scaffold to cure long-range nerve defects for the first time. 3D manufacture of melatonin/polycaprolactone nerve guide conduit increased Schwann cell proliferation and neural expression in vitro and promoted functional, electrophysiological and morphological nerve regeneration in vivo...
June 23, 2018: Journal of Pineal Research
Mervi Javanainen, Tuula Pekkarinen, Harri Mustonen, Tom Scheinin, Marja Leivonen
INTRODUCTION: Nutritional deficiencies may occur after bariatric surgery despite supplementation. Fracture risk may also be elevated after bariatric surgery. OBJECTIVES: To compare 25-hydroxyvitamin D [25(OH)D], vitamin B12, and albumin serum concentrations in severely obese patients who had undergone either Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG). Fracture data was compared with data for a conservatively treated group of severely obese patients...
June 23, 2018: Obesity Surgery
Stefan Seewald, Tiing Leong Ang, Roos E Pouw, Fridolin Bannwart, Jacques J Bergman
Barrett's esophagus with high-grade dysplasia and early-stage adenocarcinoma is amenable to curative treatment by endoscopic resection. Histopathological correlation has established that mucosal cancer has minimal risk of nodal metastases and that long-term complete remission can be achieved. Although surgery is the gold-standard treatment once there is submucosal involvement, even T1sm1 (submucosal invasion ≤ 500 μm) cases without additional risk factors for nodal metastases might also be cured with endoscopic resection...
June 23, 2018: Digestive Diseases and Sciences
Elisabeth G Biesta-Peters, Ida Jongenburger, Enne de Boer, Wilma F Jacobs-Reitsma
During the last decade Campylobacter has been the most commonly reported gastrointestinal bacterial infection in humans in the European Union. The use of a sensitive detection method based on enrichment of Campylobacter spp. is often needed when examining foods. However, as background flora developed resistance to third generation β-lactams used in selective culture media, the ISO method was adapted. It now consists of three different procedures (A, B, and C) depending on the expected concentration and condition of Campylobacter and the background microflora...
June 19, 2018: International Journal of Food Microbiology
Hua-Kung Wang, Mong-Hong Lee, Yee-Chun Chen, Po-Ren Hsueh, Shan-Chwen Chang
BACKGROUND/PURPOSE: The clinical, epidemiological, and laboratory factors associated with disease severity and mortality from confirmed leptospirosis patients in Taiwan are not well known. This retrospective study examined patients with suspected leptospirosis admitted to En-Chu-Kong Hospital, a regional teaching hospital in northern Taiwan. METHODS: From January 2002 to July 2014, 733 suspected cases were reported to the National Reference Laboratory, 57 of which were identified as laboratory and clinical confirmed...
June 6, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
Jing Zhang, Ru-Yue Han, Huo-Chun Ye, Ying Zhou, Zheng-Ke Zhang, En-Lin Yuan, Ye Li, Chao Yan, Xia Liu, Gang Feng, Yong-Xia Guo
In our previous study on natural products with fungicidal activity, pseudolaric acid B (PAB) isolated from Pseudolarix amabilis was examined to inhibit significantly mango anthracnose (Colletotrichum gloeosporioides) in vivo and in vitro. In the current study, sensitivity of 17 plant pathogenic fungi to PAB was determined. Mycelial growth rate results showed that PAB possessed strong antifungal activities to eleven fungi with median effective concentration (EC50 ) values ranging from 0.087 to 1.927μg/mL. EC50 of PAB against spore germination was greater than that of mycelium growth inhibition, which suggest that PAB could execute antifungal activity through mycelial growth inhibition...
May 2018: Pesticide Biochemistry and Physiology
Piotr Major, Piotr Małczak, Michał Wysocki, Grzegorz Torbicz, Natalia Gajewska, Michał Pędziwiatr, Andrzej Budzyński
BACKGROUND: The prevalence of obesity is growing worldwide. Malnutrition has been identified as a risk factor, leading to higher morbidity rate and prolonged length of hospital. So far there are no high quality data on the impact of malnutrition on length of hospital stay and morbidity regarding bariatric surgery. The aim of the study was to assess association between nutritional status and outcomes bariatric surgeries. MATERIAL AND METHODS: The study was a prospective observational study...
June 19, 2018: International Journal of Surgery
Sanjay K Choubey, Jeyaraman Jeyakanthan
Histone deacetylase 2 (HDAC2) is an emerging target of Alzheimer's disease. Four featured pharmacophore model (ADRR) with one H-bond acceptor (A), one H-bond donor (D), and two aromatic rings (R) was generated using experimentally reported compounds, ((E-5[3-benzenesulfonamido) phenyl]-N-hydroxypent-2-en-4-ynamide)) and (N'-hydroxy-N-phenyloctanediamide) with IC50 values of 0.16 ± 0.11 nM and 62 ± 0.15 nM, respectively. Quantum Polarized Ligand Docking and Binding Free Energy calculation was performed for the top three identified leads RH01652, JFD02573, and HTS00800 from HitFinder database...
June 22, 2018: Journal of Receptor and Signal Transduction Research
Bobbi S Stromer, Sonali Roy, Melissa R Limbacher, Bardwi Narzary, Manobjyoti Bordoloi, Julia Waldman, Challa V Kumar
Synthesis, characterization, and applications of strongly fluorescent, multicolored protein nanoparticles (GlowDots) are re-ported here. Bovine serum albumin was cross-linked under controlled conditions to form nanoparticles, where particle size was controlled from 20 to 100 ± 10 nm by choosing appropriate reaction conditions. The absorption as well as the emission wavelengths were controlled without changing the particle size, unlike quantum dots. Each GlowDot was loaded with up to 214  50 chromophores and hence, the particles have high molar absorptivities (106 M-1cm-1) as well as high brightness (105 to 106 M-1cm-1)...
June 22, 2018: Bioconjugate Chemistry
Yoshikazu Nishimura, Toru Esaki, Yoshiaki Isshiki, Naoki Okamoto, Yoshiyuki Furuta, Tomoya Kotake, Yoshiaki Watanabe, Masateru Ohta, Toshito Nakagawa, Hiroshi Noda, Masaru Shimizu, Hitoshi Saito, Tatsuya Tamura, Haruhiko Sato
During the course of derivatization of HTS hit 4a, we have identified a novel small-molecule hPTHR1 agonist, 1-(3,5-dimethyl-4-(2-((2-((1R,4R)-4-methylcyclohexyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-1-methylurea (CH5447240, 14l). Compound 14l exhibited a potent in vitro hPTHR1 agonist effect with EC20 of 3.0 nM and EC50 of 12 nM and showed excellent physicochemical properties, such as high solubility in fasted state simulated intestinal fluid and good metabolic stability in human liver microsomes...
June 22, 2018: Journal of Medicinal Chemistry
Kouji Kobiyama, Melanie Vassallo, Jessica Mitzi, Holger Winkels, Hong Pei, Takayuki Kimura, Jacqueline Miller, Dennis Wolf, Klaus Ley
Vaccination with MHC-II-restricted peptides from Apolipoprotein B (ApoB) with complete and incomplete Freund's adjuvant (CFA/IFA) is known to protect mice from atherosclerosis. This vaccination induces antigen-specific IgG1 and IgG2c antibody responses and a robust CD4 T cell response in lymph nodes. However, CFA/IFA cannot be used in humans. To find a clinically applicable adjuvant, we tested the effect of vaccinating Apoe-deficient mice with ApoB peptide P6 (TGAYSNASSTESASY). In a broad screening experiment, Addavax, a squalene oil similar to MF59, was the only adjuvant that showed similar efficacy as CFA/IFA...
June 22, 2018: European Journal of Immunology
Peiying Pai, Marthandam Asokan Shibu, Ruey-Lin Chang, Jaw-Ji Yang, Chia-Chi Su, Chao-Hung Lai, Hung-En Liao, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang
Aberrant expression of leucine zipper- and sterile ɑ motif-containing kinase (ZAK) observed in pathological human myocardial tissue is associated with the progression and elevation of hypertrophy. Our previous reports have correlated high levels of estrogen (E2) and abundant estrogen receptor (ER) α with a low incidence of pathological cardiac-hypertrophy and heart failure in the premenopause female population. However, the effect of elevated ERβ expression is not well known yet. Therefore, in this study, we have analyzed the cardioprotective effects and mechanisms of E2 and/or ERβ against ZAK overexpression-induced cellular hypertrophy...
June 22, 2018: Journal of Cellular Biochemistry
Xiaotian Zhao, Yun Qian, Yuan Cheng, Xiaoshuang Guo, Wei-En Yuan
Non-viral vector gene delivery is generally limited by its potential toxicity problems, poor transfection abilities, serum stability, or relatively complex construction processes of modified polyplexes. Thus, we develop an efficient and stable polyplex system through convenient construction methods. Here, polyethyleneimine (PEI) 1.8 kDa and glutaraldehyde (GA) are used to construct a novel twice-condensed pDNA polyplex system using a one-pot construction method, including pH-responsive C[double bond, length as m-dash]N linkages by which different PEI molecules on one single polyplex can link with each other...
June 22, 2018: Biomaterials Science
Der-Ming Chang, Wei-Jei Lee, Jung-Chien Chen, Kong-Han Ser, Pei-Ling Tsai, Yi-Chih Lee
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has been validated as a safe and effective treatment for morbid obesity. However, data of the long-term outcome remains lacking. METHODS: A total of 1759 LSG was performed as primary bariatric procedure from 2005 to 2017 with mean age of 35.2 ± 10.3 years old (14-71), female 69.7%, mean body mass index (BMI) 37.9 ± 7.7 kg/m2 , and mean waist width 113.7 ± 17.9 cm. All patients were evaluated and managed under a strict multidisciplinary team approach...
June 21, 2018: Obesity Surgery
S Chiappetta, R Weiner
BACKGROUND: The Mini gastric bypass/One anastomosis gastric bypass (MGB/OAGB) was the third most commonly performed procedure in Germany, with 13.9% of all obesity and metabolic procedures in 2017 (StuDoQ|MBE). OBJECTIVE: This article reviews the currently published evidence for MGB/OAGB and the historical evidence on one anastomosis reconstruction. MATERIAL AND METHODS: A systematic literature search was performed in MEDLINE via PubMed and in Clinicaltrials...
June 21, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Wendy Schijns, Jens Homan, Leah van der Meer, Ignace M Janssen, Cees J van Laarhoven, Frits J Berends, Edo O Aarts
Background: After Roux-en-Y gastric bypass (RYGB), patients often develop a vitamin B-12 deficiency. Objective: Our objective was to investigate whether oral supplementation increases and normalizes low vitamin B-12 concentrations (vitamin B-12 > 200 pmol/L) in RYGB patients as compared to intramuscular injections. Design: A randomized controlled trial in RYGB patients with subnormal serum B-12 concentrations was performed. One group (IM B-12) received bimonthly intramuscular hydroxocobalamin injections (2000 µg as loading dose and 1000 µg at follow-up) for 6 mo...
June 21, 2018: American Journal of Clinical Nutrition
J Daniel Diaz, Jay C Wang, Patrick Oellers, Inês Lains, Lucia Sobrin, Deeba Husain, Joan W Miller, Demetrios G Vavvas, John B Miller
Purpose: To evaluate the deeper choroidal vasculature in eyes with various ocular disorders using spectral domain (SD) optical coherence tomography angiography (OCTA) and swept source (SS) OCTA. Methods: Patients underwent OCTA imaging with either SD-OCTA (Zeiss Cirrus Angioplex or Optovue AngioVue) or SS-OCTA (Topcon Triton). Retinal pigment epithelium (RPE) integrity, structural visualization of deep choroidal vessels on en face imaging, and OCTA of deep choroidal blood flow signal were analyzed...
May 2018: Journal of vitreoretinal diseases
Dane Christina Daoud, Nicolas Suter, Madeleine Durand, Mickael Bouin, Bernard Faulques, Daniel von Renteln
AIM: To compare endoscopic submucosal dissection (ESD) outcomes between Eastern and Western countries. METHODS: A systematic review and meta-analysis was performed using PubMed, MEDLINE, Web of Science, CINAHL and EBM reviews to identify studies published between 1990 and February 2016. The primary outcome was the efficacy of ESD based on information about either curative resection, en bloc or R0 resection rates. Secondary outcomes were complication rates, local recurrence rates and procedure times...
June 21, 2018: World Journal of Gastroenterology: WJG
Micaela Raices, Ignacio Fuente, Fanny Rodriguez, Fernando Wright
With the worldwide epidemic of obesity, there has been an increase in the numbers of primary and revisional procedures of bariatric surgery such as the Roux-en-Y gastric bypass (RYGBP). Nevertheless, this type of surgery is not exempt from complications. An excessive length of non-functional Roux limb proximal to the jejunojejunostomy can cause abnormal upper gastrointestinal symptoms after laparoscopic RYGBP. We present the case of a female patient who presented these unspecific abdominal symptoms after laparoscopic RYGBP who underwent laparoscopic resection in order to reduce the length of the dilated blind loop responsible for the symptoms...
June 20, 2018: BMJ Case Reports
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