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https://www.readbyqxmd.com/read/28924280/antibiotics-use-and-misuse-in-upper-respiratory-tract-infection-patients-knowledge-attitude-and-practice-analysis-in-university-hospital-saudi-arabia
#1
Waseem Hajjar, Sami Alnassar, Sara Al-Khelb, Sarah Al-Mutairi, Norah Al-Refayi, Sultan Ayoub Meo
OBJECTIVE: To assess the awareness and causes of antibiotics use and misuse in patients with upper respiratory tract infections. METHODS: This cross-sectional study was conducted at King Saud University, Riyadh, Saudi Arabia, from January 2014 to December 2015, and comprised patients suffering from upper respiratory tract infections. A well-established, self-administrated questionnaire was randomly distributed to the patients. The questionnaire consisted of 3 parts: demographic variables, knowledge, and beliefs, and behaviour towards antibiotic use and misuse...
September 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28917069/knowledge-attitude-and-practice-of-antibiotic-use-and-misuse-among-adults-in-riyadh-saudi-arabia
#2
Nouf Al-Shibani, Abdulaziz Hamed, Nawaf Labban, Reem Al-Kattan, Hanan Al-Otaibi, Sara Alfadda
To assess the knowledge, attitude, and practice of antibiotics (ABs) use and misuse among adults living in Riyadh, Saudi Arabia. Methods: In this cross-sectional study, a self-administered questionnaire was distributed to participants from  March 2016 to January 2017 in the outpatient department of King Khalid University Hospital and Dental Hospital, King Saud University, Riyadh, Saudi Arabia. The questionnaire was divided into 4 sections. The first and second section inquired regarding demographic details and knowledge of ABs...
October 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28911637/safety-of-frozen-liver-for-human-consumption
#3
Ghada A K Kirrella, Azza M M Deeb, Reda Mohamed Ibrahim Abdallah
The objective of this study was to ensure and evaluate the safety of imported frozen beef liver traded in supermarkets of Kafr El-Sheikh Governorate, Egypt, through detection of Salmonella typhimurium, Salmonella enteritidies, Escherichia coli O157:H7, antibiotic residues, and aflatoxin B1 residue. Fifty samples of imported frozen liver were randomly collected from different shops at Kafr El-Sheikh Governorate for isolation of S. typhimurium, S. enteritidies, and E. coli O157:H7. The results revealed that for both microorganisms 4% of the examined samples presumed to contain Salmonella and E...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28904072/validation-of-a-novel-assay-to-distinguish-bacterial-and-viral-infections
#4
Isaac Srugo, Adi Klein, Michal Stein, Orit Golan-Shany, Nogah Kerem, Irina Chistyakov, Jacob Genizi, Oded Glazer, Liat Yaniv, Alina German, Dan Miron, Yael Shachor-Meyouhas, Ellen Bamberger, Kfir Oved, Tanya M Gottlieb, Roy Navon, Meital Paz, Liat Etshtein, Olga Boico, Gali Kronenfeld, Eran Eden, Robert Cohen, Helène Chappuy, François Angoulvant, Laurence Lacroix, Alain Gervaix
BACKGROUND: Reliably distinguishing bacterial from viral infections is often challenging, leading to antibiotic misuse. A novel assay that integrates measurements of blood-borne host-proteins (tumor necrosis factor-related apoptosis-inducing ligand, interferon γ-induced protein-10, and C-reactive protein [CRP]) was developed to assist in differentiation between bacterial and viral disease. METHODS: We performed double-blind, multicenter assay evaluation using serum remnants collected at 5 pediatric emergency departments and 2 wards from children ≥3 months to ≤18 years without (n = 68) and with (n = 529) suspicion of acute infection...
September 13, 2017: Pediatrics
https://www.readbyqxmd.com/read/28863269/bacteriophages-the-possible-solution-to-treat-pathogenic-bacteria
#5
Ayman El-Shibiny, Salma El-Sahhar
Bacteriophages have been used to treat bacterial infections in animals and humans since their discovery in 1915, due to their unique ability to infect their specific bacterial hosts, without affecting other bacterial populations. The research carried out in this field throughout the twentieth century, largely in Georgia, part of USSR and Poland, led to the establishment of phage therapy protocols. However, the discovery of penicillin and sulphonamide antibiotics in the Western World during the 1930's was a setback in the advancement of phage therapy...
September 1, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28831457/editorial-use-and-misuse-of-systemic-antibiotics-in-periodontitis-treatment
#6
Norbert Cionca
No abstract text is available yet for this article.
2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28805984/self-medication-misuse-in-the-middle-east-a-systematic-literature-review
#7
REVIEW
Malak M Khalifeh, Nicholas D Moore, Pascale R Salameh
Regulations usually distinguish between prescription-only (POM) and over-the-counter (OTC) medicines. The former requires medical prescription; the latter are available for SM of common minor or easily treated ailments. However, in the Eastern Mediterranean countries, theoretical prescription medicines can easily be purchased without a prescription, as self-medication (SM) resulting in potential misuse and unnecessary risk for patients. The magnitude of this activity is uncertain. The aim of this article, therefore, is to undertake a comprehensive review to identify the different types of medicines that can easily be purchased as SM in Middle East and recognized as misused...
August 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28752952/persistent-diarrhea-a-persistent-infection-with-enteropathogens-or-a-gut-commensal-dysbiosis
#8
Shafiqul A Sarker, Tahmeed Ahmed, Harald Brüssow
In children from developing countries 5 to 10 per cent of acute diarrhea (AD) episodes develop into persistent diarrhea (PD) defined by > 14 days of diarrhea duration. PD represents a major health burden leading to growth faltering. It is also associated with half of all diarrhea mortality. A rational intervention is thus crucial, but depends on an understanding of the pathogenesis of PD, which is still lacking. Many surveys were conducted in Latin America and in South Asia; they differ, however, with respect to enteropathogens associated with PD...
July 28, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28737082/myth-manners-and-medical-ritual-defensive-medicine-and-the-fetish-of-antibiotics
#9
Alex Broom, Emma Kirby, Alexandra F Gibson, Jeffrey J Post, Jennifer Broom
Given the global crisis of antimicrobial resistance, the continued misuse of antibiotics is perplexing, particularly despite persistent attempts to curb usage. This issue extends beyond traditional "wastage" areas, of livestock and community medicine, to hospitals, raising questions regarding the current principles of hospital practice. Drawing on five focus group discussions, we explore why doctors act in the ways they do regarding antibiotics, revealing how practices are done, justified, and perpetuated. We posit that antibiotic misuse is better understood in terms of social relations of fear, survival and a desire for autonomy; everyday rituals, performances, and forms of professional etiquette; and the mixed obligations evident in the health sector...
July 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/28735809/antibiotic-stewardship-in-perinatal-and-neonatal-care
#10
REVIEW
Jayashree Ramasethu, Tetsuya Kawakita
The spread of antibiotic resistance due to the use and misuse of antibiotics around the world is now a major health crisis. Neonates are exposed to antibiotics both before and after birth, often empirically because of risk factors for infection, or for non-specific signs which may or may not indicate sepsis. There is increasing evidence that, apart from antibiotic resistance, the use of antibiotics in pregnancy and in the neonatal period alters the microbiome in the fetus and neonate with an increased risk of immediate and long-term adverse effects...
October 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28692318/misconceptions-and-malpractices-toward-antibiotic-use-in-childhood-upper-respiratory-tract-infections-among-a-cohort-of-lebanese-parents
#11
Ghada El Khoury, Elsy Ramia, Pascale Salameh
Antimicrobial resistance is an emerging global health threat. Misuse and abuse of antibiotics are of particular concern in the pediatric population. Since management of childhood illnesses depends considerably on parents' perceptions, the objectives of this study were to report parents' perspectives and assess their practices toward antibiotics used for upper respiratory tract infections (URTIs) in children. Using a cross-sectional design, anonymous structured questionnaires were completed by 1,037 parents in public and private schools across Lebanon's largest governorate...
January 1, 2017: Evaluation & the Health Professions
https://www.readbyqxmd.com/read/28668688/massive-misuse-of-antibiotics-by-university-students-in-all-regions-of-china-implications-for-national-policy
#12
Xiaomin Wang, Dandan Peng, Weiyi Wang, Yannan Xu, Xudong Zhou, Therese Hesketh
Antimicrobial resistance (AMR) is one of the greatest threats to global health this century. The primary cause of AMR is antibiotic misuse, especially routine use of antibiotics for self-limiting illnesses. This study aimed to explore behaviours related to antibiotic use in university students across China. An electronic questionnaire was distributed at a major university in each of the six regions. A cluster random sampling method was adopted. The χ(2) test and logistic regression were used to assess the relationship between knowledge and behaviour...
June 28, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28665050/assessing-the-public-acceptability-of-proposed-policy-interventions-to-reduce-the-misuse-of-antibiotics-in-australia-a-report-on-two-community-juries
#13
Chris Degeling, Jane Johnson, Jon Iredell, Ky-Anh Nguyen, Jacqueline M Norris, John D Turnidge, Angus Dawson, Stacy M Carter, Gwendolyn L Gilbert
OBJECTIVE: To elicit the views of well-informed community members on the acceptability of proposed policy interventions designed to improve community use of antibiotics in Australia. DESIGN: Two community juries held in 2016. SETTING AND PARTICIPANTS: Western Sydney and Dubbo communities in NSW, Australia. Twenty-nine participants of diverse social and cultural backgrounds, mixed genders and ages recruited via public advertising: one jury was drawn from a large metropolitan setting; the other from a regional/rural setting...
June 30, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28664525/structure-and-functional-characterisation-of-a-distinctive-%C3%AE-lactamase-from-an-environmental-strain-emb20-of-bacillus-cereus
#14
Ayesha Sadaf, Rajeshwari Sinha, S K Khare
The rampant use and misuse of antibiotics in human medicine, agriculture and veterinary have become the key contributors to global antimicrobial resistance. One of the significant resistance mechanisms that inactivates antibiotics and impedes treatment of bacterial infections is the expression of β-lactamases. Rising evidence of newer variants of β-lactamases in the environment is therefore a serious threat to the presently available antibiotic armoury. The present work describes the purification of a variant β-lactamase isolated from a soil strain EMB20 of Bacillus cereus...
June 29, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28655370/antibiotic-stewardship-in-long-term-care-a-call-to-action
#15
Caren McHenry Martin
The Centers for Medicare & Medicaid Services and the Centers for Disease Control and Prevention are focused heavily on curbing the misuse of antibiotics in health care facilities. Regulations governing the management of antibiotics in the nursing facility will likely be changing in the near future, which will put the pharmacist at the forefront of a clinical team that is dedicated to proper antibiotic utilization. Savvy pharmacists are embracing this opportunity to engage long-term care facility staff to improve the care of their residents...
May 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28647106/-outpatient-consumption-of-antibiotics-with-a-bacterial-resistance-risk-in-2014-in-france
#16
Marie-Céline Casaurancq, Emilie Patras de Campaigno, Manuela Rueter, Bérangère Baricault, Robert Bourrel, Maryse Lapeyre-Mestre, Agnès Sommet
AIM: This article proposes a description of French regional consumption of antibiotics with a bacterial resistance risk (amoxicillin+clavulanic acid, third-generation cephalosporins [C3G] and fluoroquinolones). METHODS: Antibiotics reimbursements data were obtained by Open Medic website. The antibiotic consumption profile has been established using some indicators of the European Surveillance of Antimicrobial Consumption (ESAC) in daily-defined dose per 1000 inhabitants per day (DID) or in percentage...
May 26, 2017: Thérapie
https://www.readbyqxmd.com/read/28587974/a-randomized-controlled-trial-of-sitafloxacin-vs-ertapenem-as-a-switch%C3%A2-therapy-after-treatment-for-acute-pyelonephritis-caused-by-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-a-pilot-study
#17
Chitprasong Malaisri, Angsana Phuphuakrat, Arrug Wibulpolprasert, Pitak Santanirand, Sasisopin Kiertiburanakul
BACKGROUND: The overuse and misuse of carbapenems have contributed to the antibiotic resistance crisis. The role of oral fluoroquinolones as a switch therapy for the treatment of urinary tract infection from Escherichia coli (ESBL-EC) is limited. OBJECTIVE: To compare the clinical and bacteriological efficacy of sitafloxacin and ertapenem for non-bacteremic acute pyelonephritis caused by ESBL-EC. METHODS: A prospective randomized controlled trial of patients with acute pyelonephritis caused by ESBL-EC was performed as a pilot study...
August 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28587172/the-rising-tide-of-antimicrobial-resistance-in-aquaculture-sources-sinks-and-solutions
#18
REVIEW
Joy E M Watts, Harold J Schreier, Lauma Lanska, Michelle S Hale
As the human population increases there is an increasing reliance on aquaculture to supply a safe, reliable, and economic supply of food. Although food production is essential for a healthy population, an increasing threat to global human health is antimicrobial resistance. Extensive antibiotic resistant strains are now being detected; the spread of these strains could greatly reduce medical treatment options available and increase deaths from previously curable infections. Antibiotic resistance is widespread due in part to clinical overuse and misuse; however, the natural processes of horizontal gene transfer and mutation events that allow genetic exchange within microbial populations have been ongoing since ancient times...
June 1, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28574575/genomics-of-antibiotic-resistance-prediction-in-pseudomonas-aeruginosa
#19
REVIEW
Julie Jeukens, Luca Freschi, Irena Kukavica-Ibrulj, Jean-Guillaume Emond-Rheault, Nicholas P Tucker, Roger C Levesque
Antibiotic resistance is a worldwide health issue spreading quickly among human and animal pathogens, as well as environmental bacteria. Misuse of antibiotics has an impact on the selection of resistant bacteria, thus contributing to an increase in the occurrence of resistant genotypes that emerge via spontaneous mutation or are acquired by horizontal gene transfer. There is a specific and urgent need not only to detect antimicrobial resistance but also to predict antibiotic resistance in silico. We now have the capability to sequence hundreds of bacterial genomes per week, including assembly and annotation...
June 2, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28573108/spreading-of-pandemic-vibrio-parahaemolyticus-o3-k6-and-its-serovariants-a-re-analysis-of-strains-isolated-from-multiple-studies
#20
Dongsheng Han, Fei Yu, Hui Tang, Chuanli Ren, Caiyun Wu, Pan Zhang, Chongxu Han
In China, V. parahaemolyticus has been a leading cause of foodborne outbreaks and bacterial infectious diarrhea since the 1990s, and most infections have been associated with the pandemic V. parahaemolyticus O3:K6 and its serovariants. However, a comprehensive overview of the sero-prevalence and genetic diversity of the pandemic V. parahaemolyticus clone in China is lacking. To compensate for this deficiency, pandemic isolates in both clinical and environmental Chinese samples collected from multiple studies were analyzed in this study...
2017: Frontiers in Cellular and Infection Microbiology
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