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antibiotic misuse

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https://www.readbyqxmd.com/read/29788885/application-of-traditional-chinese-herbal-medicine-by-products-as-dietary-feed-supplements-and-antibiotic-replacements-in-animal-production
#1
Abedin Abdallah, Pei Zhang, Qingzhen Zhong, Zewei Sun
Misuse of synthetic antibiotics in livestock leads to the transfer of antibiotic resistant pathogens into humans and deposits toxic residues in meat and milk. There is therefore an urgent need for safe and viable alternative approaches to improve the nutrition and wellbeing of farm animals. An alternative source that has been widely exploited is traditional Chinese herbal medicine (TCHM). These herbal medicines are an important part of the healthcare system in many Asian countries. Such herbs contain several but less toxic bioactive compounds which are generally regarded biodegradable...
May 22, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29788293/the-efficacy-of-social-cognitive-theory-based-self-care-intervention-for-rational-antibiotic-use-a-randomized-trial
#2
Bahram Mohebbi, Azar Tol, Roya Sadeghi, Mehdi Yaseri, Negar Akbari Somar, Feleke Doyore Agide
Background: Misuse of antibiotics can be described as a failure to complete treatment, skipping of the doses and reuse of leftover medicines and overuse of antibiotics. Health education interventions are expected to enhance awareness and general belief on rational antibiotics use. Therefore, the study aimed to determine the efficacy of social cognitive theory (SCT)-based self-care intervention for rational antibiotic use. Methods: This randomized trial was conducted in a sample of 260 adults...
May 19, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29778048/pathogens-constancy-harbinger-of-nosocomial-infection-cum-identification-of-resistant-genes-and-drug-designing
#3
Sana Farooq Ahmad, Ibrar Khan, Abdul Wadood, Sadiq Azam, Noor Rehman, Muhammad Waqas, Kashif Bashir, Asaf Ali Khan
Hospitals are the most prominent places for the growth and spread of bacteria which are resistant to the available antibiotics. This antibiotic resistance is due to the over and misuse of antibiotic dosages of a high-density of patient population which are in frequent interaction with inanimate items of the hospitals and the consequent risk of cross infection. Out of 1010 samples of the current study, 510 (50.49%) were culture positive of which 329 (64.5%) were Gram-positive while 181 (35.49%) Gram negative...
April 22, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29761047/a-survey-of-the-views-and-capabilities-of-community-pharmacists-in-western-australia-regarding-the-rescheduling-of-selected-oral-antibiotics-in-a-framework-of-pharmacist-prescribing
#4
Fatima Sinkala, Richard Parsons, Bruce Sunderland, Kreshnik Hoti, Petra Czarniak
Background: Antibiotic misuse in the community contributes to antimicrobial resistance. One way to address this may be by better utilizing community pharmacists' skills in antibiotic prescribing. The aims of this study were to examine the level of support for "down-scheduling" selected antibiotics and to evaluate factors determining the appropriateness of community pharmacist prescribing for a limited range of infections, including their decision to refer to a doctor. Methods: Self-administered questionnaires, including graded case vignette scenarios simulating real practice, were sent to Western Australian community pharmacists...
2018: PeerJ
https://www.readbyqxmd.com/read/29744041/the-social-biography-of-antibiotic-use-in-smallholder-dairy-farms-in-india
#5
Abhimanyu Singh Chauhan, Mathew Sunil George, Pranab Chatterjee, Johanna Lindahl, Delia Grace, Manish Kakkar
Background: Antimicrobial resistance (AMR) has been identified as one of the major threats to global health, food security and development today. While there has been considerable attention about the use and misuse of antibiotics amongst human populations in both research and policy environments, there is no definitive estimate of the extent of misuse of antibiotics in the veterinary sector and its contribution to AMR in humans. In this study, we explored the drivers ofirrational usage of verterinary antibiotics in the dairy farming sector in peri-urban India...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29743330/protocol-for-a-randomised-trial-of-higher-versus-lower-intensity-patient-provider-communication-interventions-to-reduce-antibiotic-misuse-in-two-paediatric-ambulatory-clinics-in-the-usa
#6
Kathy Goggin, Andrea Bradley-Ewing, Angela L Myers, Brian R Lee, Emily A Hurley, Kirsten B Delay, Sarah Schlachter, Areli Ramphal, Kimberly Pina, David Yu, Kirsten Weltmer, Sebastian Linnemayr, Christopher C Butler, Jason G Newland
INTRODUCTION: Children with acute respiratory tract infections (ARTIs) are prescribed up to 11.4 million unnecessary antibiotic prescriptions annually. Inadequate parent-provider communication is a chief contributor, yet efforts to reduce overprescribing have only indirectly targeted communication or been impractical. This paper describes our multisite, parallel group, cluster randomised trial comparing two feasible interventions for enhancing parent-provider communication on the rate of inappropriate antibiotic prescribing (primary outcome) and revisits, adverse drug reactions and parent-rated quality of shared decision-making, parent-provider communication and visit satisfaction (secondary outcomes)...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29738478/honey-wound-repair-and-regenerative-medicine
#7
REVIEW
Simona Martinotti, Elia Ranzato
Honey possesses anti-bacterial, anti-inflammatory and other properties that are useful for wound healing and tissue regeneration. Furthermore, honey has been used for millennia in folk medicine. The misuse of antibiotics has again boosted the use of honey in regenerative medicine. The multifaceted properties of honey could possibly be exploited for scaffold applications in tissue healing.
May 8, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29707795/harmless-friendly-and-lethal-antibiotic-misuse-in-relation-to-the-unpredictable-bacterium-group-a-streptococcus
#8
Hedvig Gröndal
Evidence-based treatment guidelines for managing infections in health care are promoted as tools to prevent unnecessary use of antibiotics. Antibiotic misuse has been examined as regards the doctor-patient relation and the social context of medical practice. Less attention has been paid to how the very conceptualisation of human-microbial relations may influence understandings of antibiotic misuse. The article examines a medical controversy concerning guidelines for managing throat infection and antibiotic treatment in Sweden...
April 29, 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29693642/antibiotic-prescribing-for-oro-facial-infections-in-the-paediatric-outpatient-a-review
#9
REVIEW
Najla Dar-Odeh, Hani T Fadel, Shaden Abu-Hammad, Rua'a Abdeljawad, Osama A Abu-Hammad
There are many reports on the complications associated with antibiotics abuse during the treatment of paediatric patients, particularly those related to antimicrobial resistance. The dental profession is no exception; there is growing evidence that dental practitioners are misusing antibiotics in the treatment of their paediatric patients. This review is directed to dental practitioners who provide oral healthcare to children. It is also directed to medical practitioners, particularly those working in emergency departments and encountering children with acute orofacial infections...
April 25, 2018: Antibiotics
https://www.readbyqxmd.com/read/29686487/global-governance-mechanisms-to-address-antimicrobial-resistance
#10
Ponnu Padiyara, Hajime Inoue, Marc Sprenger
Since their discovery, antibiotics, and more broadly, antimicrobials, have been a cornerstone of modern medicine. But the overuse and misuse of these drugs have led to rising rates of antimicrobial resistance, which occurs when bacteria adapt in ways that render antibiotics ineffective. A world without effective antibiotics can have drastic impacts on population health, global development, and the global economy. As a global common good, antibiotic effectiveness is vulnerable to the tragedy of the commons, where a shared limited resource is overused by a community when each individual exploits the finite resource for their own benefit...
2018: Infectious Diseases
https://www.readbyqxmd.com/read/29685459/educational-intervention-to-enhance-adherence-to-short-term-use-of-antibiotics
#11
Lorna Marie West, Maria Cordina
BACKGROUND: Non-adherence to short-term antibiotics is considered to be one of the factors leading to medicines wastage, and this can increase misuse of medicine taking, promote antibiotic resistance and cause environmental pollution. Interventions developed to enhance adherence to short-term antibiotics should be easily implementable into daily practice. No studies utilising Normalization Process Theory to develop interventions aiming to enhance adherence to antibiotics were identified...
April 11, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29674796/prescriber-and-dispenser-perceptions-about-antibiotic-use-in-acute-uncomplicated-childhood-diarrhea-and-upper-respiratory-tract-infection-in-new-delhi-qualitative-study
#12
Anita Kotwani, P C Joshi, Urmila Jhamb, Kathleen Holloway
OBJECTIVE: The objective of the study was to explore the prescribing practices, knowledge, and attitudes of primary care doctors and community pharmacists, regarding antibiotic use in acute upper respiratory tract infections (URTI) and diarrhea in children to better understand causes of misuse and identify provider suggestions to change such behavior. MATERIALS AND METHODS: Two focus group discussions (FGDs) each were conducted with primary care government doctors (GDs), private general practitioners (GPs), pediatricians, and community pharmacists in Delhi...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29659359/-pneumonia-associated-with-mechanical-ventilation-update-and-recommendations-inter-societies-sadi-sati
#13
Wanda Cornistein, Ángel M Colque, María Inés Staneloni, María Monserrat Lloria, Mónica Lares, Ana Laura González, Alejandro Fernández Garcés, Edith Carbone
Representatives of the Argentine Society of Infectious Diseases (SADI) and the Argentine Society of Intensive Therapy (SATI) worked together on the development of specific recommendations for the diagnosis, treatment and prevention of ventilator-associated pneumonia (VAP). The methodology used was the analysis of the literature published in the last 15 years, complemented with the opinion of experts and local data. This document aims to offer basic tools to optimize diagnosis based on clinical and microbiological criteria, orientation in empirical and targeted antibiotic schemes, news on posology and administration of antibiotics in critical patients and to promote effective measures to reduce the risk of VAP...
2018: Medicina
https://www.readbyqxmd.com/read/29627625/the-depressed-central-carbon-and-energy-metabolisms-is-associated-to-the-acquisition-of-levofloxacin-resistance-in-vibrio-alginolyticus
#14
Zhi-Xue Cheng, Man-Jun Yang, Bo Peng, Xuan-Xian Peng, Xiang-Min Lin, Hui Li
The overuse and misuse of antibiotics lead to bacterial antibiotic resistance, challenging human health and intensive cultivation. It is especially required to understand for the mechanism of antibiotic resistance to control antibiotic-resistant pathogens. The present study characterized the differential proteome of levofloxacin-resistant Vibrio alginolyticus with the most advanced iTRAQ quantitative proteomics technology. A total of 160 proteins of differential abundance were identified, where 70 were decreased and 90 were increased...
April 5, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29625943/drug-utilization-and-prescribing-pattern-of-antibiotics-in-a-tertiary-care-setups-trends-and-practices
#15
Huma Ali, Farya Zafar, Shazia Alam, Anwar Ejaz Beg, Rabia Bushra, Ammara Manzoor, Ghazala R Naqvi, Riffat Yasmeen, Yousra Shafiq, Anum Tariq, Saba Zubair, Saima Saleem
Irrational, over and misuse of antibiotics arise as global concern in both hospital and community settings and lead to adverse events including antimicrobial resistance, associated health problems, amplified hospitalization stay and cost. Hence, Drug Utilization Evaluation (DUE) studies are designed to evaluate and improve the prescribing, administration and the rational use of medications. The present study was designed to assess the pattern of antimicrobial drug utilization in in-patients cohort of tertiary care setup in Karachi, Pakistan...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29608688/oxytetracycline-does-not-cause-growth-promotion-in-finfish
#16
Jesse T Trushenski, Matthew P Aardsma, Kelli J Barry, James D Bowker, Christopher J Jackson, Michelle Jakaitis, Rebecca L McClure, Artur N Rombenso
Until recently, use of antibiotics to enhance terrestrial animal growth performance was a common, U.S. Food and Drug Administration-approved, but controversial practice. There are no FDA-approved production claims for antibiotic drug use in fish, but it is a common misconception that antibiotics are widely used for this purpose in U.S. aquaculture. Antibiotics are not thought to be effective growth promoters in fish, but there is little quantitative data available to address whether there are growth-promoting effects that might incentivize use of antibiotics in this way, despite legal prohibitions...
March 28, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29605741/degradation-and-removal-of-ceftriaxone-sodium-in-aquatic-environment-with-bi-2-wo-6-g-c-3-n-4-photocatalyst
#17
Yanyan Zhao, Xuhua Liang, Yongbo Wang, Huanxian Shi, Enzhou Liu, Jun Fan, Xiaoyun Hu
Modern chemistry aims to identify outstanding photocatalytic materials for antibiotic degradation given the overuse and misuse of antibiotics. Herein, highly efficient heterojunction photocatalysts composed of Bi2 WO6 nanoflowers (BW) and g-C3 N4 nanosheets (CNNs) were successfully synthesized. The Bi2 WO6 /g-C3 N4 (BW/CNNs) were presented for Ceftriaxone sodium degradation in the aquatic environment at low concentrations under visible light irradiation. The 40%-BW/CNNs showed excellent photocatalytic activity, and approximately 94...
March 26, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29604537/chronic-exposure-to-low-environmental-concentrations-and-legal-aquaculture-doses-of-antibiotics-cause-systemic-adverse-effects-in-nile-tilapia-and-provoke-differential-human-health-risk
#18
Samwel M Limbu, Li Zhou, Sheng-Xiang Sun, Mei-Ling Zhang, Zhen-Yu Du
BACKGROUND: Antibiotics used globally to treat human and animal diseases exist ubiquitously in the environment at low doses because of misuse, overdose and poor absorption after ingestion, coupled with their high-water solubility and degradation resistance. However, the systemic chronic effects of exposure to low environmental concentrations of antibiotics (LECAs) and legal aquaculture doses of antibiotics (LADAs) in fish and their human health risk are currently unknown. OBJECTIVE: To investigate the in vivo chronic effects of exposure to LECAs and LADAs using oxytetracycline (OTC) and sulfamethoxazole (SMZ) in Nile tilapia (Oreochromis niloticus) and their human health risk...
March 27, 2018: Environment International
https://www.readbyqxmd.com/read/29592834/patient-compliance-with-antimicrobial-drugs-a-chinese-survey
#19
Shuangmei Tong, Jiaqian Pan, Shan Lu, Jing Tang
BACKGROUND: Antimicrobial therapy is among the mainstream treatment modalities employed in clinical settings. Antimicrobial sensitivity of the pathogen and patient compliance are key determinants of the efficacy of antimicrobial therapy. OBJECTIVE: In this study, we sought to investigate the factors that affect patient compliance to antimicrobial therapy in a Chinese teaching hospital to enhance patient compliance and to prevent abuse and misuse of antibiotics by patients...
April 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29587768/antibiotic-resistance-pattern-and-virulence-genes-content-in-avian-pathogenic-escherichia-coli-apec-from-broiler-chickens-in-chitwan-nepal
#20
Manita Subedi, Himal Luitel, Bhuminanda Devkota, Rebanta Kumar Bhattarai, Sarita Phuyal, Prabhat Panthi, Anil Shrestha, Dhiraj Kumar Chaudhary
BACKGROUND: Avian pathogenic Escherichia coli (APEC) are causative agent of extraintestinal infections, collectively known as colibacillosis, which results significant losses in poultry industries. The extraintestinal survival of E. coli is facilitated by numerous virulence factors which are coded by virulence genes. This study was conducted to find out the pattern of antibiotic resistance and virulence genes content in the APEC strains isolated from broiler chickens at National Avian Disease Investigation Laboratory and Veterinary Teaching Hospital, Rampur, Chitwan, Nepal...
March 27, 2018: BMC Veterinary Research
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