keyword
MENU ▼
Read by QxMD icon Read
search

selenium cardiac surgery

keyword
https://www.readbyqxmd.com/read/27795837/effects-of-low-dose-selenium-on-the-inflammatory-response-in-coronary-artery-bypass-graft-surgery-a-clinical-trial
#1
Abbas Sedighinejad, Vali Imantalab, Ali Mirmansouri, Ali Mohammadzadeh Jouryabi, Gholamreza Kanani, Nassir Nassiri Sheikhani, Mohammad Haghighi, Zahra Atrkarroushan, Gelareh Biazar
BACKGROUND: Coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB) triggers an inflammatory reaction, leading to the development of myocardial damage and dysfunction. It is suggested that selenium (Se), an essential trace element, has a protective role against oxidative stress. Decreased intraoperative Se levels might be an independent predictive factor for postoperative multiorgan failure. In spite of its proposed advantages, however, the optimal timing and dosage are not well known...
August 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27406157/low-preoperative-selenium-is-associated-with-post-operative-atrial-fibrillation-in-patients-having-intermediate-risk-coronary-artery-surgery
#2
C McDonald, J Fraser, K Shekar, A Clarke, J Coombes, A Barnett, B Pearse, L Fung
BACKGROUND/OBJECTIVES: Post-operative atrial fibrillation (POAF) is a frequent complication of cardiac surgery. Oxidative stress and reduced antioxidant function have major roles in its development. Selenium is a key to normal antioxidant function, and levels are often low before cardiac surgery. This study investigated whether low preoperative selenium levels were associated with POAF in cardiac surgical patients. SUBJECTS/METHODS: Using the Society of Thoracic Surgeons (STS) Mortality risk score, 50 patients having primary coronary artery bypass grafts (CABG) surgery were divided into two groups: (i) low-risk group (STS ⩽0...
July 13, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27192987/selenium-pretreatment-for-mitigation-of-ischemia-reperfusion-injury-in-cardiovascular-surgery-influence-on-acute-organ-damage-and-inflammatory-response
#3
Holger Steinbrenner, Esra Bilgic, Antonio Pinto, Melanie Engels, Lena Wollschläger, Laura Döhrn, Kristine Kellermann, Udo Boeken, Payam Akhyari, Artur Lichtenberg
Ischemia/reperfusion injury (IRI) contributes to morbidity and mortality after cardiovascular surgery requiring cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA). Multi-organ damage is associated with substantial decreases of blood selenium (Se) levels in patients undergoing cardiac surgery with CPB. We compared the influence of a dietary surplus of Se and pretreatment with ebselen, a mimic of the selenoenzyme glutathione peroxidase, on IRI-induced tissue damage and inflammation. Male Wistar rats were fed either a Se-adequate diet containing 0...
August 2016: Inflammation
https://www.readbyqxmd.com/read/25923656/selenium-and-its-supplementation-in-cardiovascular-disease-what-do-we-know
#4
REVIEW
Carina Benstoem, Andreas Goetzenich, Sandra Kraemer, Sebastian Borosch, William Manzanares, Gil Hardy, Christian Stoppe
The trace element selenium is of high importance for many of the body's regulatory and metabolic functions. Balanced selenium levels are essential, whereas dysregulation can cause harm. A rapidly increasing number of studies characterizes the wide range of selenium dependent functions in the human body and elucidates the complex and multiple physiological and pathophysiological interactions of selenium and selenoproteins. For the majority of selenium dependent enzymes, several biological functions have already been identified, like regulation of the inflammatory response, antioxidant properties and the proliferation/differentiation of immune cells...
May 2015: Nutrients
https://www.readbyqxmd.com/read/25169040/sodium-selenite-adminstration-in-cardiac-surgery-sustain-csx-trial-study-design-of-an-international-multicenter-randomized-double-blinded-controlled-trial-of-high-dose-sodium-selenite-administration-in-high-risk-cardiac-surgical-patients
#5
RANDOMIZED CONTROLLED TRIAL
Christian Stoppe, Bernard McDonald, Steffen Rex, William Manzanares, Richard Whitlock, Stephen Fremes, Robert Fowler, Yoan Lamarche, Patrick Meybohm, Christoph Haberthür, Rolf Rossaint, Andreas Goetzenich, Gunnar Elke, Andrew Day, Daren K Heyland
BACKGROUND: Cardiac surgery has been shown to result in a significant decrease of the antioxidant selenium, which is associated with the development of multiorgan dysfunction and increased mortality. Thus, a large-scale study is needed to investigate the effect of perioperative selenium supplementation on the occurrence of postoperative organ dysfunction. METHODS/DESIGN: We plan a prospective, randomized double-blind, multicenter controlled trial, which will be conducted in North and South America and in Europe...
2014: Trials
https://www.readbyqxmd.com/read/25118980/the-importance-of-intraoperative-selenium-blood-levels-on-organ-dysfunction-in-patients-undergoing-off-pump-cardiac-surgery-a-randomised-controlled-trial
#6
RANDOMIZED CONTROLLED TRIAL
Ana Stevanovic, Mark Coburn, Ares Menon, Rolf Rossaint, Daren Heyland, Gereon Schälte, Thilo Werker, Willibald Wonisch, Michael Kiehntopf, Andreas Goetzenich, Steffen Rex, Christian Stoppe
INTRODUCTION: Cardiac surgery is accompanied by an increase of oxidative stress, a significantly reduced antioxidant (AOX) capacity, postoperative inflammation, all of which may promote the development of organ dysfunction and an increase in mortality. Selenium is an essential co-factor of various antioxidant enzymes. We hypothesized a less pronounced decrease of circulating selenium levels in patients undergoing off-pump coronary artery bypass (OPCAB) surgery due to less intraoperative oxidative stress...
2014: PloS One
https://www.readbyqxmd.com/read/23030412/selenium-and-cardiovascular-surgery-an-overview
#7
REVIEW
Fengwei Guo, Nadejda Monsefi, Anton Moritz, Andres Beiras-Fernandez
Selenium is an essential nutritional element to mammalians necessary for the active function of different oxidant enzymes, as glutathione peroxidase (GPx), thioredoxin reductases (TrxR), and iodothyronine deiodinases (IDD). The anti-oxidative effect of selenium is pivotal for the human physiology. Oxidative stress is associated with various diseases, such as cardiovascular disease, diabetes mellitus or cancer, and is also associated with the majority of surgical procedures. Particularly, the use of cardiopulmonary bypass for open cardiac surgery with aortic clamping is always related to oxidative stress due to ischemia and reperfusion...
September 2012: Current Drug Safety
https://www.readbyqxmd.com/read/23010420/selenium-blood-concentrations-in-patients-undergoing-elective-cardiac-surgery-and-receiving-perioperative-sodium-selenite
#8
Christian Stoppe, Jan Spillner, Rolf Rossaint, Mark Coburn, Gereon Schälte, Anika Wildenhues, Gernot Marx, Steffen Rex
OBJECTIVES: We recently reported that cardiac surgical patients in our institution exhibited low selenium blood levels preoperatively, which were further aggravated during surgery and independently associated with the development of postoperative multiorgan failure. Low circulating selenium levels result in a decreased antioxidant capacity. Both can be treated effectively by sodium-selenite administration. Little is known about the kinetics of exogenously administered sodium-selenite during acute perioperative oxidative stress...
January 2013: Nutrition
https://www.readbyqxmd.com/read/22847607/lower-whole-blood-selenium-level-is-associated-with-higher-operative-risk-and-mortality-following-cardiac-surgery
#9
György Koszta, Zoltán Kacska, Katalin Szatmári, Tamás Szerafin, Béla Fülesdi
PURPOSE: The authors intended to test their hypothesis that a low blood selenium level is associated with higher mortality, morbidity, and increased inflammatory response following cardiac surgery. METHODS: A single-center clinical survey was conducted on 197 consecutive patients undergoing on-pump operation in Debrecen, Hungary. Blood samples for whole blood selenium analysis were taken immediately before the surgery. Their risk profiles were evaluated according to the EuroSCORE...
December 2012: Journal of Anesthesia
https://www.readbyqxmd.com/read/22460776/antioxidant-trace-element-reduction-in-an-in-vitro-cardiopulmonary-bypass-circuit
#10
Charles I McDonald, Yoke Lin Fung, John F Fraser
Many complications occurring after cardiac surgery are attributed to an acute increase in reactive oxygen and reactive nitrogen species, which under normal conditions are balanced by the antioxidant response. Two key enzymes of the antioxidant response, glutathione peroxidase (GPx) and superoxide dismutase (SOD), rely on trace elements for normal function. It was hypothesized that circulation of blood through the cardiopulmonary bypass (CPB) circuit would 1) reduce trace element levels and antioxidant function, 2) increase oxidative stress, and that 3) prepriming circuits with albumin would ameliorate trace element loss...
May 2012: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/21460705/the-intraoperative-decrease-of-selenium-is-associated-with-the-postoperative-development-of-multiorgan-dysfunction-in-cardiac-surgical-patients
#11
COMPARATIVE STUDY
Christian Stoppe, Gereon Schälte, Rolf Rossaint, Mark Coburn, Beatrix Graf, Jan Spillner, Gernot Marx, Steffen Rex
OBJECTIVE: The trace elements selenium, copper, and zinc are essential for maintaining the oxidative balance. A depletion of antioxidative trace elements has been observed in critically ill patients and is associated with the development of multiorgan dysfunction and an increased mortality. Cardiac surgery using cardiopulmonary bypass provokes ischemia-reperfusion-mediated oxidative stress. We hypothesized that an intraoperative decrease of circulating trace elements may be involved in this response...
August 2011: Critical Care Medicine
https://www.readbyqxmd.com/read/20674497/perioperative-metabolic-therapy-improves-redox-status-and-outcomes-in-cardiac-surgery-patients-a-randomised-trial
#12
RANDOMIZED CONTROLLED TRIAL
Jee-Yoong Leong, Juliana van der Merwe, Salvatore Pepe, Michael Bailey, Anthony Perkins, Robyn Lymbury, Donald Esmore, Silvana Marasco, Franklin Rosenfeldt
OBJECTIVE: Perioperative therapy with antioxidants and metabolic substrates has the potential to reduce oxidative stress and improve recovery from cardiac surgery, particularly in elderly and high risk cases. The aim of this study was to assess the effect of perioperative metabolic therapy at a biochemical, clinical and economic level in cardiac surgical patients. METHODS: Patients (n=117, mean age 65 ± 1.0 years, 74% male) undergoing elective coronary artery bypass graft (CABG) and/or valve surgery in 2004-2006 were randomised to receive in double blinded fashion, while on the waiting list for surgery (approximately two months) and one month after surgery, either metabolic therapy (coenzyme Q(10), magnesium orotate, lipoic acid, omega-3 fatty acids and selenium) or placebo...
October 2010: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/19998236/-reperfusion-and-potential-damages-in-heart-surgery
#13
P Feindt
No abstract text is available yet for this article.
December 2009: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/18687132/influence-of-early-antioxidant-supplements-on-clinical-evolution-and-organ-function-in-critically-ill-cardiac-surgery-major-trauma-and-subarachnoid-hemorrhage-patients
#14
RANDOMIZED CONTROLLED TRIAL
Mette M Berger, Ludivine Soguel, Alan Shenkin, Jean-Pierre Revelly, Christophe Pinget, Malcolm Baines, René L Chioléro
INTRODUCTION: Oxidative stress is involved in the development of secondary tissue damage and organ failure. Micronutrients contributing to the antioxidant (AOX) defense exhibit low plasma levels during critical illness. The aim of this study was to investigate the impact of early AOX micronutrients on clinical outcome in intensive care unit (ICU) patients with conditions characterized by oxidative stress. METHODS: We conducted a prospective, randomized, double-blind, placebo-controlled, single-center trial in patients admitted to a university hospital ICU with organ failure after complicated cardiac surgery, major trauma, or subarachnoid hemorrhage...
2008: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/18468827/targeting-oxidative-stress-in-surgery-effects-of-ageing-and-therapy
#15
REVIEW
Salvatore Pepe, Jee-Yoong Leong, Juliana Van der Merwe, Silvana F Marasco, Anthony Hadj, Robyn Lymbury, Anthony Perkins, Franklin L Rosenfeldt
In the current era cardiac surgeons are being called upon to operate upon older, sicker patients. The effect is to augment oxidative stress and increase the rate of post-operative complications and ultimately mortality. We have developed antioxidant-based pre-treatment regimes initially based on coenzyme Q(10). A randomised trial of coenzyme Q(10) in elective cardiac surgery patients demonstrated augmented plasma and cardiac mitochondrial membrane coenzyme Q(10) content, improved mitochondrial respiration and increased myocardial tolerance of oxidative stress...
July 2008: Experimental Gerontology
https://www.readbyqxmd.com/read/17324623/nutritional-deficiency-of-selenium-secondary-to-weight-loss-bariatric-surgery-associated-with-life-threatening-cardiomyopathy
#16
Rachel Boldery, George Fielding, Tony Rafter, Andrew L Pascoe, Gregory M Scalia
Nutritional deficiencies of vitamins and minerals have been associated with reversible and irreversible cardiomyopathic processes. Selenium deficient dilated cardiomyopathy, first described in 1935 in the Keshan Province of China, was sometimes reversed with selenium supplementation. In the past three decades, selenium deficient cardiomyopathy has re-emerged in western medicine secondary to gastrointestinal disorders, long-term total parenteral nutrition (TPN) and gastrointestinal surgery. This report describes a case of selenium deficient cardiomyopathy secondary to the bariatric (weight loss) surgical operation bilio-pancreatic diversion (Scopinaro procedure)...
April 2007: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/11759183/cigarette-smoking-is-independently-associated-with-markers-of-endothelial-dysfunction-and-hyperinsulinaemia-in-nondiabetic-individuals-with-coronary-artery-disease
#17
B R Winkelmann, B O Boehm, M Nauck, P Kleist, W März, N K Verho, N Ranjith, G Kneissl
BACKGROUND: Oxidative stress and endothelial dysfunction have been introduced as a unifying pathological mechanism for early atherosclerotic disease. They are caused by a variety of stimuli including cigarette smoking (environmental) and type 2 diabetes (disease factor). However, the role of hyperinsulinemia, a marker of insulin resistance, as a risk factor for atherosclerosis remains to be clarified. STUDY OBJECTIVES: To study the relationship of smoking, hyperinsulinaemia and biochemical markers of oxidative stress and endothelial dysfunction, in patients with coronary artery disease...
2001: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/8325303/element-concentrations-selenium-copper-zinc-iron-magnesium-potassium-phosphorous-in-heart-tissue-of-patients-with-coronary-heart-disease-correlated-with-physiological-parameters-of-the-heart
#18
O Oster, M Dahm, H Oelert
The element concentrations (Cu, Zn, Se, Fe, K, Mg, P) of heart tissue taken from patients with coronary heart disease during bypass surgery were measured and related to physiological parameters of the heart. There was no relationship between the element concentrations and the number of vessels stenosed, the occurrence of myocardial infarction or classification according to the NYHA. When the element concentrations of the heart were related with parameters characterizing cardiac output, such as ejection fraction and cardiac index, positive statistically significant correlations were found for selenium, iron, copper, zinc and phosphorus...
June 1993: European Heart Journal
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"