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Intravenous paracetamol

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https://www.readbyqxmd.com/read/29792347/fewer-adverse-effects-associated-with-a-modified-two-bag-intravenous-acetylcysteine-protocol-compared-to-traditional-three-bag-regimen-in-paracetamol-overdose
#1
Lars E Schmidt, Ditlev N Rasmussen, Tonny S Petersen, Ines M Macias-Perez, Leo Pavliv, Byron Kaelin, Richard C Dart, Kim Dalhoff
CONTEXT: The intravenous (IV) N-acetylcysteine (NAC) regimen used worldwide in paracetamol overdose is complex with three separate weight-based doses and is associated with a high incidence of adverse events including non-allergic anaphylactoid reactions (NAARs). In 2012, Denmark adopted the two-bag IV NAC regimen which combined the first two infusions of the three-bag regimen and kept the third infusion unchanged. We compared the safety and efficacy of the two-bag IV NAC regimen with the traditional Danish three-bag regimen...
May 24, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29783269/adding-paracetamol-to-ibuprofen-for-the-treatment-of-patent-ductus-arteriosus-in-preterm-infants-a-double-blind-randomized-placebo-controlled-pilot-study
#2
Ori Hochwald, Gur Mainzer, Liron Borenstein-Levin, Huda Jubran, Gil Dinur, Meirav Zucker, Malka Mor, Asaad Khoury, Amir Kugelman
OBJECTIVE:  The objective of this study was to compare the closure rate of hemodynamically significant patent ductus arteriosus (hsPDA) of intravenous ibuprofen + paracetamol (acetaminophen) versus ibuprofen + placebo, in preterm infants of 24 to 316/7 weeks postmenstrual age. STUDY DESIGN:  This is a single-center, double-blind, randomized controlled pilot study. Infants were assigned for treatment with either intravenous ibuprofen + paracetamol ( n  = 12) or ibuprofen + placebo ( n  = 12)...
May 21, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29782641/the-analgesic-efficacy-and-pharmacokinetics-of-epidural-oxycodone-after-gynaecologic-laparotomy-a-randomised-double-blind-double-dummy-comparison-with-intravenous-administration
#3
Panu Piirainen, Hannu Kokki, Heidi Hautajärvi, Veli-Pekka Ranta, Merja Kokki
AIM: To compare the analgesic efficacy of epidural and i.v. oxycodone at the same dose. METHODS: In this randomised, double-blind, double-dummy clinical trial 30 women, aged 24-67 years, undergoing elective gynaecologic laparotomy were administrated either i.v. saline and epidural oxycodone 0.1 mg·kg-1 (EPI-group; n=15) or i.v. oxycodone 0.1 mg·kg-1 and epidural saline (IV-group; n=15). For multimodal analgesia patients received i.v. paracetamol and dexketoprofen, and a triple-mixture epidural infusion after the first four postoperative hours...
May 21, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29742719/cauda-equina-syndrome-following-an-uneventful-spinal-anesthesia-in-a-patient-undergoing-drainage-of-the-bartholin-abscess-a-case-report
#4
Waldo Merino-Urrutia, Milca Villagrán-Schmidt, Priscilla Ulloa-Vásquez, Rubén Carrasco-Moyano, Alberto Uribe, Nicoleta Stoicea, Sergio D Bergese
RATIONALE: Neuraxial anesthesia is a commonly used type of regional anesthesia. Cauda equina syndrome is an unusual and severe complication of neuraxial anesthesia, and is caused by damage to the sacral roots of the neural canal. We present a case of cauda equina syndrome following spinal anesthesia in a patient who underwent Bartholin abscess drainage. PATIENT CONCERNS: A 23-year old female scheduled to undergo surgical drainage of Bartholin abscess. Spinal anesthesia was performed with bupivacaine and fentanyl...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29741427/time-course-of-subacute-pain-after-transoral-robotic-surgery-tors-for-oropharyngeal-squamous-cell-carcinoma-versus-traditional-bilateral-tonsillectomy-in-adults-a-case-control-study
#5
Susanne Irene Scott, Anne Kathrine Østergaard Madsen, Niclas Rubek, Hani Ibrahim Channir, Henrik Kehlet, Christian von Buchwald
OBJECTIVE: To examine pain after Transoral Robotic Surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC) versus traditional bilateral tonsillectomy in adults. METHODS: Pain evolvement was assessed in a prospective case-control design of 16 consecutive patients treated with TORS for early stage OPSCC versus 12 patients, who underwent bilateral tonsillectomy on suspicion of malignant disease. The TORS group received an optimized analgesia regime of preoperative oral celecoxib and gabapentin, intra- and postoperative high-dose intravenous dexamethasone, and regular postoperative oral contalgin, gabapentin, celecoxib, paracetamol and rescue morphine...
May 9, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29739543/special-indications-for-opioid-free-anaesthesia-and-analgesia-patient-and-procedure-related-including-obesity-sleep-apnoea-chronic-obstructive-pulmonary-disease-complex-regional-pain-syndromes-opioid-addiction-and-cancer-surgery
#6
REVIEW
Adrian Sultana, David Torres, Roman Schumann
Opioid-free anaesthesia (OFA) is a technique where no intraoperative systemic, neuraxial or intracavitary opioid is administered with the anaesthetic. Opioid-free analgesia similarly avoids opioids in the perioperative period. There are many compelling reasons to avoid opioids in the surgical population. A number of case reports and, increasingly, prospective studies from all over the world support its benefits, especially in the morbidly obese population with or without sleep apnoea. A derivative technique is opioid sparing, where the same techniques are used but some opioid use is allowed...
December 2017: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/29701425/analgesia-management-for-mitral-valve-repair-via-minithoracotomy-a-case-report
#7
Andreia Fernandes, Clara Gaio Lima, Nelson Paulo, Catarina Celestino, Ana Fonte Boa, Fátima Lima, Manuela Vieira
INTRODUCTION: Minimally invasive cardiac surgery (MICS), via minithoracotomy, is thought to be a fast track to extubation and recovery after surgery. Chronic pain, due to intercostal nerve injury, develops in up to 50% of postthoracotomy patients.A number of regional anaesthesia and analgesia techniques may be employed, and the anaesthesiologists play a key role in facilitating optimal outcomes after surgery. METHODS: We report a case of postoperative pain management with a local anesthetic infiltration for MICS...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29686807/pain-alleviation-in-patients-undergoing-cardiac-surgery-presternal-local-anesthetic-and-magnesium-infiltration-versus-conventional-intravenous-analgesia-a-randomized-double-blind-study
#8
Emad Zarief Kamel, Sayed Kaoud Abd-Elshafy, Jehan Ahmed Sayed, Mohammed Mahmoud Mostafa, Mohamed Ismail Seddik
Background: Magnesium is one of the effective, safe local anesthetic adjuvants that can exert an analgesic effect in conditions presenting acute and chronic post-sternotomy pain. We studied the efficacy of continuous infusion of presternal magnesium sulfate with bupivacaine for pain relief following cardiac surgery. Methods: Ninety adult patients undergoing valve replacement cardiac surgery randomly allocated into three groups. In all patients; a presternal catheter was placed for continuous infusion of either 0...
April 2018: Korean Journal of Pain
https://www.readbyqxmd.com/read/29659631/the-hemodynamic-effects-of-intravenous-paracetamol-acetaminophen-vs-normal-saline-in-cardiac-surgery-patients-a-single-center-placebo-controlled-randomized-study
#9
Elizabeth Chiam, Rinaldo Bellomo, Leonid Churilov, Laurence Weinberg
The hemodynamic effects of intravenous (IV) paracetamol in patients undergoing cardiac surgery are unknown. We performed a prospective single center placebo controlled randomized study with parallel group design in adult patients undergoing elective cardiac surgery. Participants received paracetamol (1 gram) IV or placebo (an equal volume of 0.9% saline) preoperatively followed by two postoperative doses 6 hours apart. The primary endpoint was the absolute change in systolic (SBP) 30 minutes after the preoperative infusion, analysed using an ANCOVA model...
2018: PloS One
https://www.readbyqxmd.com/read/29624206/paracetamol-acetaminophen-for-patent-ductus-arteriosus-in-preterm-or-low-birth-weight-infants
#10
REVIEW
Arne Ohlsson, Prakeshkumar S Shah
BACKGROUND: In preterm newborns, the ductus arteriosus frequently fails to close and the infants require medical or surgical closure of the patent ductus arteriosus (PDA). A PDA can be treated surgically; or medically with one of two prostaglandin inhibitors, indomethacin or ibuprofen. Case reports suggest that paracetamol may be an alternative for the closure of a PDA. An association between prenatal or postnatal exposure to paracetamol and later development of autism or autism spectrum disorder has been reported...
April 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29618196/the-course-of-intracranial-pressure-after-antipyretic-therapy-in-acute-brain-injury
#11
Edoardo Picetti, Patrizia Ceccarelli, Laura Malchiodi, Francesca Mensi, Solange Risolo, Franco Servadei, Corrado Iaccarino, Ilaria Rossi, Sandra Rossi
BACKGROUND: The present study was performed to evaluate intracranial pressure (ICP) variations after antipyretic therapy and their relationship to ICP at baseline (ICPbas) in acute brain injury (ABI) patients. METHODS: We completed a retrospective analysis on data derived from 2 previously published prospective observational studies. The first study involved 32 ABI patients and was performed to elucidate the cerebral and hemodynamic effects of intravenous (IV) paracetamol...
April 4, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29559326/canadian-trends-in-carpal-tunnel-surgery
#12
Blair Peters, Jennifer L Giuffre
PURPOSE: Treatment patterns of carpal tunnel surgery by members of the American Society of Surgery of the Hand (ASSH) have recently been published. The majority of cases in this study were performed in the general operating room with intravenous (IV) sedation or a Bier block. Patients were most commonly prescribed hydrocodone for postoperative pain. The majority of carpal tunnel releases at our center are performed under local anesthesia alone, with plain acetaminophen (Tylenol) or codeine prescribed for postoperative pain...
March 17, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29526831/iv-dexketoprofen-vs-iv-paracetamol-in-patients-presented-with-dysmenorrhea-to-emergency-department-a-randomized-controlled-trial
#13
Mustafa Serinken, Cenker Eken, Özgür Karcıoğlu
BACKGROUND: Dysmenorrhea is one of the most common acute pain disorders among women of reproductive age. AIMS: The present study aimed to compare the effects of IV paracetamol to dexketoprofen in patients presented with primary dysmenorrhea to the emergency department. STUDY DESIGN: Randomized Controlled Trial. METHODS: Patients over 18 years old presented with pelvic pain related to menstruation were accepted as eligible for the study...
February 2, 2018: Balkan Medical Journal
https://www.readbyqxmd.com/read/29513963/the-effect-of-total-and-partial-nephrectomy-on-the-pharmacokinetics-of-intravenous-paracetamol-in-humans
#14
COMPARATIVE STUDY
Agnieszka Karbownik, Wojciech Polom, Joanna Porazka, Edyta Szalek, Tomasz Grabowski, Anna Wolc, Matuszewski Marcin, Edmund Grzesowiak
Paracetamol is one of the most common analgesic and antipyretic drugs. Recently intravenous paracetamol has been widely used to treat moderate postoperative pain. Surgery is the main method of treatment of renal cancer. Total or partial nephrectomy can be performed, depending on the size and location of the tumor. Pharmacokinetics of drugs may depend on the type of surgery. The aim of the study was to compare the postinfusion pharmacokinetics of paracetamol in patients after total nephrectomy (TN) and nephron sparing surgery (NSS)...
May 2017: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/29492399/efficacy-of-paracetamol-in-closure-of-ductus-arteriosus-in-infants-under-32-weeks-of-gestation
#15
Ines Tofe, Maria Dolores Ruiz-González, Maria Dolores Cañete, Asuncion Pino, Rosa Lorena Rueda, Maria Jose Parraga, Juan Luis Perez-Navero
Background: Standard medical treatment for patent ductus arteriosus (PDA) closure has been indomethacin/ibuprofen or surgical ligation. Up to date, new strategies have been reported with paracetamol. The aim of this study was to present our experience with intravenous paracetamol for closing PDA in preterm neonates presenting contraindication to ibuprofen or ibuprofen had failed and no candidates for surgical ligation because of huge instability. Materials and methods: We conducted a retrospective case series study in a neonatal intensive care unit from a tertiary hospital...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29489610/intravenous-paracetamol-overdose-a-pediatric-case-report
#16
Nagehan Aslan, Dincer Yildizdas, Didar Arslan, Ozden Ozgur Horoz, Hayri Levent Yilmaz, Sevcan Bilen
Paracetamol is a common antipyretic often used to treat children with fever and pain. With the increasing administration of intravenous (IV) paracetamol, there will be the associated risk of medication dosing errors. We report a case of IV paracetamol overdose in a child with fever during hospital admission. A IV paracetamol dosing error occurred, with delayed recognition resulting in transient hepatotoxicity, with a peak alanine transaminase of 1946 IU/L and aspartate transaminase of 1633 IU/L.
February 28, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29473717/interventions-for-paracetamol-acetaminophen-overdose
#17
REVIEW
Angela L Chiew, Christian Gluud, Jesper Brok, Nick A Buckley
BACKGROUND: Paracetamol (acetaminophen) is the most widely used non-prescription analgesic in the world. Paracetamol is commonly taken in overdose either deliberately or unintentionally. In high-income countries, paracetamol toxicity is a common cause of acute liver injury. There are various interventions to treat paracetamol poisoning, depending on the clinical status of the person. These interventions include inhibiting the absorption of paracetamol from the gastrointestinal tract (decontamination), removal of paracetamol from the vascular system, and antidotes to prevent the formation of, or to detoxify, metabolites...
February 23, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29450877/effect-of-intravenous-preoperative-versus-postoperative-paracetamol-on-postoperative-nausea-and-vomiting-in-patients-undergoing-strabismus-surgery-a-prospective-randomized-study
#18
Mehmet Aksoy, İlker İnce, Ali Ahıskalıoğlu, Sadullah Keleş, Ömer Doymuş
OBJECTIVES: This prospective randomized study aimed to compare the efficacy of preoperative versus postoperative paracetamol on postoperative nausea and vomiting (PONV) in children undergoing strabismus surgery. METHODS: Ninety-six patients were randomly divided into three equal groups (n=32). In the preoperative paracetamol group, patients received intravenous (IV) infusion of paracetamol [15 mg kg-1 (1.5 ml kg-1)] 1 h before surgery over 20 min and that of saline (1...
January 2018: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/29416244/comparison-of-maintenance-emergence-and-recovery-characteristics-of-sevoflurane-and-desflurane-in-pediatric-ambulatory-surgery
#19
Manish B Kotwani, Anila D Malde
Background and Aims: Increasing number of pediatric ambulatory surgeries are being carried out in general anesthesia using supraglottic airways (SGAs). Literature comparing sevoflurane and desflurane for the maintenance of SGA-based anesthesia is limited. Hence, we planned this prospective randomized study to compare the maintenance, emergence and recovery characteristics of sevoflurane and desflurane for pediatric ambulatory surgery. Material and Methods: Sixty children aged 6 months to 6 years posted for short surgical procedures were enrolled into the study...
October 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29326825/staphylococcal-scalded-skin-syndrome-a-pediatric-dermatology-case-report
#20
Girish Gulab Meshram, Neeraj Kaur, Kanwaljeet Singh Hura
Staphylococcal scalded skin syndrome is a condition which predominantly affects children and causes a spectrum of skin lesions. We present a case of a 2-month-old infant with complaints of fever and fragile blisters over the body. The mucosal areas were spared. The diagnosis of staphylococcal scalded skin syndrome was reached on clinical grounds and culture report. The patient responded well to the treatment, which included an antibiotic (cloxacillin), an analgesic (paracetamol), and hydration with intravenous fluids...
2018: SAGE open medical case reports
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