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https://www.readbyqxmd.com/read/28728476/a-perspective-on-diuretic-resistance-in-chronic-congestive-heart-failure
#1
Niel Shah, Raef Madanieh, Mehmet Al Kan, Muhammad U Dogar, Constantine E Kosmas, Timothy J Vittorio
Chronic congestive heart failure (CHF) is a complex disorder characterized by inability of the heart to keep up the demands on it, followed by the progressive pump failure and fluid accumulation. Although the loop diuretics are widely used in heart failure (HF) patients, both pharmacodynamic and pharmacokinetic alterations are thought to be responsible for diuretic resistance in these patients. Strategies to overcome diuretic resistance include sodium intake restriction, changes in diuretic dose and route of administration and sequential nephron diuretic therapy...
July 1, 2017: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/28723150/double-imaging-photoelectron-photoion-coincidence-sheds-new-light-on-the-dissociation-of-state-selected-ch3f-ions
#2
Xiaofeng Tang, Gustavo A Garcia, Laurent Nahon
The vacuum ultraviolet (VUV) photoionization and dissociative photoionization of methyl fluoride (CH3F) in the 12.2-19.8 eV energy range were investigated by using synchrotron radiation coupled to a double imaging photoelectron photoion coincidence (i(2)PEPICO) spectrometer. The production of several fragment ions including CH2F(+), CHF(+), CH3(+) and CH2(+) as a function of state and internal energy of CH3F(+) ions was identified and analyzed, with their individual appearance energies measured through threshold photoelectron spectroscopy...
July 19, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28719009/diagnosis-of-chronic-heart-failure-by-the-soluble-suppression-of-tumorigenicity-2-and-n-terminal-pro-brain-natriuretic-peptide
#3
Xiao-Ling Jin, Ning Huang, Hui Shang, Ming-Cheng Zhou, Yi Hong, Wen-Zheng Cai, Jie Huang
OBJECTIVE: Our study was to explore the roles between serum soluble suppression of tumorigenicity 2 (sST2) and N-terminal pro-brain natriuretic peptide (NT-proBNP) while evaluating ventricular function to properly diagnose chronic heart failure (CHF). METHODS: In total, 197 CHF patients were recruited and classified into ventricular function's II, III, and IV groups, and 106 healthy people into normal control group. To detect concentrations of Sst2 and NT-proBNP, ELISA and electro-chemiluminescence immuno assay were implemented...
July 18, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28718661/anxiety-and-self-care-behaviour-in-patients-with-chronic-systolic-heart-failure-a-multivariate-model
#4
Thomas Müller-Tasch, Bernd Löwe, Nicole Lossnitzer, Lutz Frankenstein, Tobias Täger, Markus Haass, Hugo Katus, Jobst-Hendrik Schultz, Wolfgang Herzog
BACKGROUND: While comprehensive evidence exists regarding negative effects of depression on self-care behaviours in patients with chronic heart failure (CHF), the relation between anxiety and self-care behaviours in patients with CHF is not clear. The aim of this study was to analyse the interactions between anxiety, depression and self-care behaviours in patients with CHF. METHODS: The self-care behaviour of CHF outpatients was measured using the European Heart Failure Self-care Behaviour Scale (EHFScBS)...
July 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28708197/risk-stratification-personalised-model-for-prediction-of-life-threatening-ventricular-tachyarrhythmias-in-patients-with-chronic-heart-failure
#5
Alexander Vladimirovich Frolov, Tatjana Gennadjevna Vaikhanskaya, Olga Petrovna Melnikova, Anatoly Pavlovich Vorobiev, Ludmila Michajlovna Guel
BACKGROUND: The development of prognostic factors of life-threatening ventricular tachyarrhythmias (VTA) and sudden cardiac death (SCD) continues to maintain its priority and relevance in cardiology. The development of a method of personalised prognosis based on multifactorial analysis of the risk factors associated with life-threatening heart rhythm disturbances is considered a key research and clinical task. AIM: To design a prognostic and mathematical model to define personalised risk for life-threatening VTA in patients with chronic heart failure (CHF)...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28707730/complement-and-contact-system-activation-in-acute-congestive-heart-failure-patients
#6
Chiara Suffritti, Eleonora Tobaldini, Riccardo Schiavon, Silvia Strada, Lorena Maggioni, Satish Mehta, Giulia Sandrone, Edgar Toschi-Dias, Marco Cicardi, Nicola Montano
BACKGROUND: Recent experimental data indicate a pathogenic role of complement activation in congestive heart failure (CHF). Aim of this study was to evaluate contact and complement systems activation in patients hospitalized for an acute episode of CHF. METHODS AND RESULTS: 42 of 80 consecutive patients admitted at our hospital with confirmed diagnosis of acute CHF were enrolled. They underwent blood sampling within 24 hours from admission (T0) and at clinical stability (T1)...
July 14, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28705092/serum-allantoin-and-aminothiols-as-biomarkers-of-chronic-heart-failure
#7
Elizabeth Caussé, Pauline Fournier, Jérome Roncalli, Robert Salvayre, Michel Galinier
Background Oxidative stress (OS) represents the primary mediator of chronic heart failure (CHF) development and progression. It is well established that homocysteine is able to generate reactive oxygen species. Small amounts of allantoin in human serum result from free radical action on urate and may provide a stable marker for in vivo free radical activity. To investigate whether some easily measurable indexes such as antioxidants (uric acid, glutathione) and related molecules (allantoin, homocysteine and cysteine) can serve as OS biomarkers...
July 14, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28701688/a-new-paradigm-for-understanding-and-enhancing-the-critical-heat-flux-chf-limit
#8
Abdolreza Fazeli, Saeed Moghaddam
Nearly a century of research on enhancing critical heat flux (CHF) has focused on altering the boiling surface properties such as its nucleation site density, wettability, wickability and heat transfer area. But, a mechanism to manipulate dynamics of the vapor and liquid interactions above the boiling surface as a means of enhancing CHF has not been proposed. Here, a new approach is implemented to limit the vapor phase lateral expansion over the heat transfer surface and actively control the surface wetted area fraction, known to decline monotonically with increasing heat flux...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28700753/acute-kidney-injury-after-cardiac-surgery-is-associated-with-mid-term-but-not-long-term-mortality-a-cohort-based-study
#9
Alejandro Ferreiro, Raúl Lombardi
Acute kidney injury (AKI) in cardiac surgery is associated with complications, early and late mortality and increased health care expenditures. The overall dynamic comorbidity-adjusted contributions of an episode of AKI on mortality during long-term follow-up have not been fully explored. A longitudinal cohort of 7075 adult patients admitted for cardiac surgery were enrolled in the study. Follow-up data were obtained through telephonic survey after 1, 5, 10, and 15 years or from the National Mortality Registry...
2017: PloS One
https://www.readbyqxmd.com/read/28695549/iron-substitution-in-the-treatment-of-chronic-heart-failure
#10
Christine Gstrein, Matthias Meyer, Pablo Anabitarte
Iron deficiency is a prevalent and clinically relevant comorbidity in up to 50% of patients with chronic heart failure (CHF). Iron deficiency in CHF patients is associated with impaired quality of life, reduced exercise capacity and increased mortality, irrespective of the presence of anaemia. It is diagnosed by determining circulating ferritin levels and transferrin saturation. Three randomised trials (CONFIRM-HF, FAIR-HF, and EFFECT-HF) of intravenous ferric carboxymaltose in the treatment of iron deficiency in CHF patients with reduced left ventricular ejection fraction demonstrated improvement of symptoms, functional capacity and quality of life...
July 11, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28695463/effects-of-exercise-training-on-anabolic-and-catabolic-markers-in-patients-with-chronic-heart-failure-a-systematic-review
#11
REVIEW
Chien-Tzu Lee, Ling-Wei Chen, Meng-Yueh Chien
Decreased anabolism because of alterations in the insulin-like growth factor 1 (IGF-1)/growth hormone (GH) axis and increased catabolism induced by proinflammatory cytokines like tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) have been reported to contribute to muscle wasting in chronic heart failure (CHF). However, it is unclear whether exercise training could modulate anabolic and catabolic markers in CHF patients. The purpose of this study was to investigate the effects of exercise intervention on anabolic and catabolic markers for patients with CHF...
July 11, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28693297/evaluation-of-a-fixed-dose-combination-of-benazepril-and-pimobendan-in-dogs-with-congestive-heart-failure-a-randomized-non-inferiority-clinical-trial
#12
Jonathan N King, Atsushi Hirakawa, Junko Sonobe, Hiroshi Otaki, Nobuhiro Sakakibara, Wolfgang Seewald, Sophie Forster
A new fixed dose combination tablet of benazepril and pimobendan (Fortekor Plus) was tested in dogs with congestive heart failure (CHF) caused by myxomatous mitral valve disease (MMVD) in a prospective, multi-center, parallel-group, three-arm, masked, randomized, non-inferiority clinical trial in 67 dogs in Japan. The test group received Fortekor Plus twice daily (n=34). Two control groups received the registered formulations of benazepril (Fortekor) and pimobendan (Vetmedin) with administration of pimobendan twice daily and benazepril twice (Control I, n=14) or once (Control II, n=19) daily...
July 10, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28691995/the-role-of-psychological-stress-on-heart-autophagy-in-mice-with-heart-failure
#13
Xiao-Ting Lu, Xiao-Qiong Liu, Bo Wang, Yuan-Yuan Sun, Rui-Xue Yang, Yi-Fan Xing, Ping Sun, Ying-Bin Wang, Yu-Xia Zhao
OBJECTIVE: Psychological stress in chronic heart failure (CHF) is associated with systemic neurohormonal and immune system responses and increased mortality. Autophagy refers to the biological process of degradation and recycling of dysfunctional cellular components. We investigated the role of psychological stress on autophagy function in CHF mice. RESULTS: A one-week stress exposure significantly increased serum levels of corticosterone and Ang II (P= .000), increased levels of oxidative stress, induced overt heart failure, and increased mortality (P =...
July 7, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28685712/effects-of-traditional-chinese-medicine-shensong-yangxin-capsules-on-heart-rhythm-and-function-in-congestive-heart-failure-patients-with-frequent-ventricular-premature-complexes-a-randomized-double-blind-multicenter-clinical-trial
#14
Xi Wang, Dan Hu, Song Dang, He Huang, Cong-Xin Huang, Ming-Jie Yuan, Yan-Hong Tang, Qing-Shan Zheng, Fang Yin, Shu Zhang, Bo-Li Zhang, Run-Lin Gao
BACKGROUND: Pharmacological therapy for congestive heart failure (CHF) with ventricular arrhythmia is limited. In the study, our aim was to evaluate the effects of Chinese traditional medicine Shensong Yangxin capsules (SSYX) on heart rhythm and function in CHF patients with frequent ventricular premature complexes (VPCs). METHODS: This double-blind, placebo-controlled, multicenter study randomized 465 CHF patients with frequent VPCs to the SSYX (n = 232) and placebo groups (n = 233) for 12 weeks of treatment...
July 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28679013/impact-of-consultation-on-hospital-outcomes-and-resource-utilization-for-patients-with-acute-congestive-heart-failure
#15
Zoltan Varga, Syed Ali Rafay Sabzwari, Khalid Abusaada
OBJECTIVES: Consultation is an important tool for acquiring subspecialty support when managing patients with acute congestive heart failure (CHF). The effect of consultation on hospital outcomes and resource utilization in CHF is unknown. The objectives of our study were to determine the effect of consultation on outcomes in CHF and to evaluate factors affecting the frequency of consultation. METHODS: Our study was a retrospective cohort study of patients admitted to Florida Hospital Orlando for CHF between January 1, 2011 and December 31, 2013...
July 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28678807/risk-of-cardiovascular-disease-in-chinese-patients-with-rheumatoid-arthritis-a-cross-sectional-study-based-on-hospital-medical-records-in-10-years
#16
Kun Zou, Fu-Kun Xiao, Hong-Ying Li, Qiao Zhou, Lu Ban, Min Yang, Chang-Fu Kuo, Weiya Zhang
OBJECTIVE: Though the risk of cardiovascular disease (CVD) in rheumatoid arthritis (RA) has been established in Western population, little is known about the risk in Chinese people with RA. Our objective was to estimate the risk of CVD in Chinese people with RA using hospital medical records data. METHODS: The inpatients medical record database 2005-2015 of Sichuan provincial people's hospital was examined. All individuals with a primary diagnosis of RA were included as cases, and those of osteoarthritis (OA) were included as controls, which consisted of the unmatched dataset...
2017: PloS One
https://www.readbyqxmd.com/read/28676385/syncope-workup-greater-yield-in-select-trauma-population
#17
Melike Harfouche, Michael Cline, Michael Mazzei, Thomas Santora
BACKGROUND: There is great variation in practice regarding the assessment of trauma patients who present with syncope. The purpose of this study was to determine the yield of screening studies (electrocardiogram, echocardiogram, and carotid duplex) and define characteristics to identify groups that may benefit from these investigations. METHODS: We conducted a retrospective cohort study of all trauma patients from 2003 to 2015 who received a carotid duplex as part of a syncope evaluation at our urban Level 1 Trauma Center...
July 1, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28674538/involvement-of-cytokines-in-the-pathogenesis-of-salt-and-water-imbalance-in-congestive-heart-failure
#18
Zaher S Azzam, Safa Kinaneh, Fadel Bahouth, Reem Ismael-Badarneh, Emad Khoury, Zaid Abassi
Congestive heart failure (CHF) has become a major medical problem in the western world with high morbidity and mortality rates. CHF adversely affects several systems, mainly the kidneys and the lungs. While the involvement of the renin-angiotensin-aldosterone system and the sympathetic nervous system in the progression of cardiovascular, pulmonary, and renal dysfunction in experimental and clinical CHF is well established, the importance of pro-inflammatory mediators in the pathogenesis of this clinical setting is still evolving...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28671938/cardiac-rehabilitation-participation-rates-and-outcomes-for-patients-with-heart-failure
#19
Jason L Rengo, Patrick D Savage, Trace Barrett, Philip A Ades
PURPOSE: Exercise training has been shown to reduce combined cardiovascular mortality and hospitalizations in patients with chronic heart failure (CHF) with reduced ejection fraction (HFrEF). Whereas there are extensive data on exercise training for individuals with HFrEF in a research setting, the experience of delivering cardiac rehabilitation (CR) services in the clinical setting has not been well described. With little knowledge regarding the number of qualifying patients with HFrEF in the United States, we described our 18-month experience recruiting hospitalized inpatients and stable outpatients into phase 2 CR...
June 30, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28669433/asymptomatic-canine-degenerative-valve-disease-current-and-future-therapies
#20
REVIEW
Sonya G Gordon, Ashley B Saunders, Sonya R Wesselowski
Degenerative valve disease (DVD) is the leading cause of heart disease and congestive heart failure (CHF) in the dog. The first published consensus statement provided guidelines for diagnosis and treatment of DVD. Although treatment was not recommended in stage B1 DVD, consensus was not reached regarding evidence-based recommendations for treatment of stage B2 DVD. This article addresses the impact of new evidence on historical recommendations for stage B DVD, and gives the reader a glimpse into possible future therapies...
June 29, 2017: Veterinary Clinics of North America. Small Animal Practice
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