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https://www.readbyqxmd.com/read/29051336/exercise-limitations-in-heart-failure-with-reduced-and-preserved-ejection-fraction
#1
David C Poole, Russell S Richardson, Mark J Haykowsky, Daniel M Hirai, Timothy I Musch
The hallmark symptom of chronic heart failure (CHF) syndrome is severe exercise intolerance. Impaired perfusive and diffusive O2 transport are two of the major determinants of reduced physical capacity and lowered maximal O2 uptake (VO2max) in CHF patients. It has now become evident that this syndrome manifests two different phenotypic variations: heart failure with preserved or reduced ejection fraction (HFpEF and HFrEF, respectively). Unlike HFrEF, however, there is currently limited understanding of HFpEF pathophysiology leading to a lack of effective pharmacological treatments for this subpopulation...
October 19, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29051335/coronary-capillary-blood-flow-in-a-rat-model-of-congestive-heart-failure
#2
Heather J Kagan, Varujan D Belekdanian, Jiqiu Chen, Peter Backeris, Nadjib Hammoudi, Irene C Turnbull, Kevin D Costa, Roger J Hajjar
The aim of this study is to explore the role of abnormal coronary microvasculature morphology and hemodynamics in the development of congestive heart failure (CHF). METHODS: CHF was induced in rats by aortic banding, followed by ischemia/reperfusion and later aortic debanding. Polymerized casts of coronary vasculature were imaged under a Scanning Electron Microscope (SEM). Matrix Laboratory (MATLAB) software was used to calculate Capillary Structure Index (CSI), a measure of structural alignment also called Mean Vector Length (MVL), for 93 SEM images of coronary capillaries (CSI→ 1 perfect linearity, CSI→ 0 circular disarray)...
October 19, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29050560/the-pcsk9-ldl-receptor-axis-and%C3%A2-outcomes-in-heart-failure-biostat-chf-subanalysis
#3
Antoni Bayes-Genis, Julio Núñez, Faiez Zannad, João Pedro Ferreira, Stefan D Anker, John G Cleland, Kenneth Dickstein, Gerasimos Filippatos, Chim C Lang, Leong L Ng, Piotr Ponikowski, Nilesh J Samani, Dirk J van Veldhuisen, Aeilko H Zwinderman, Marco Metra, Josep Lupón, Adriaan A Voors
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds low-density lipoprotein receptor (LDLR), preventing its recycling. PCSK9 is a risk predictor and a biotarget in atherosclerosis progression. OBJECTIVES: The aim of this study was to determine whether the PCSK9-LDLR axis could predict risk in patients with heart failure (HF). METHODS: The BIOSTAT-CHF (Biology Study to Tailored Treatment in Chronic Heart Failure) is a multicenter, multinational, prospective, observational study that included patients with worsening HF signs and/or symptoms...
October 24, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29042849/does-coordinated-postpartum-care-influence-costs
#4
Elisabeth Zemp, Andri Signorell, Elisabeth Kurth, Oliver Reich
QUESTIONS UNDER STUDY: To investigate changes to health insurance costs for post-discharge postpartum care after the introduction of a midwife-led coordinated care model. METHODS: The study included mothers and their newborns insured by the Helsana health insurance group in Switzerland and who delivered between January 2012 and May 2013 in the canton of Basel Stadt (BS) (intervention canton). We compared monthly post-discharge costs before the launch of a coordinated postpartum care model (control phase, n = 144) to those after its introduction (intervention phase, n = 92)...
March 31, 2017: International Journal of Integrated Care
https://www.readbyqxmd.com/read/29042392/renal-and-cardiovascular-effects-of-sodium-glucose-cotransporter-2-sglt2-inhibition-in-combination-with-loop-diuretics-in-diabetic-patients-with-chronic-heart-failure-recede-chf-protocol-for-a-randomised-controlled-double-blind-cross-over-trial
#5
Natalie A Mordi, Ify R Mordi, Jagdeep S Singh, Fatima Baig, Anna-Maria Choy, Rory J McCrimmon, Allan D Struthers, Chim C Lang
INTRODUCTION: Type 2 diabetes (T2D) and heart failure (HF) are a frequent combination, where treatment options remain limited. There has been increasing interest around the sodium-glucose cotransporter 2 (SGLT2) inhibitors and their use in patients with HF. Data on the effect of SGLT2 inhibitor use with diuretics are limited. We hypothesise that SGLT2 inhibition may augment the effects of loop diuretics and the benefits of SGLT2 inhibitors may extend beyond those of their metabolic (glycaemic parameters and weight loss) and haemodynamic parameters...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29037770/dietary-nitrate-supplementation-opposes-the-elevated-diaphragm-blood-flow-in-chronic-heart-failure-during-submaximal-exercise
#6
Joshua R Smith, Scott K Ferguson, K Sue Hageman, Craig A Harms, David C Poole, Timothy I Musch
Chronic heart failure (CHF) results in a greater cost of breathing and necessitates an elevated diaphragm blood flow (BF). Dietary nitrate (NO3‾) supplementation lowers the cost of exercise. We hypothesized that dietary NO3‾ supplementation would attenuate the CHF-induced greater cost of breathing and thus the heightened diaphragm BF during exercise. CHF rats received either 5days of NO3‾-rich beetroot (BR) juice (CHF+BR, n=10) or a placebo (CHF, n=10). Respiratory muscle BFs (radiolabeled microspheres) were measured at rest and during submaximal exercise (20m/min, 5% grade)...
October 13, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29037148/effectiveness-of-a-precede-based-education-intervention-on-quality-of-life-in-elderly-patients-with-chronic-heart-failure
#7
Qiong Wang, Lini Dong, Zaijin Jian, Xianghua Tang
BACKGROUND: One of the most important challenges in public health is to improve the quality of life in patients with chronic heart failure (CHF). Depression, self-care capacity, and quality of life interact each other in these patients. It's difficult to treat with general education programs and conventional therapy. PRECEDE model is a comprehensive and exclusive theory-based education programs. Its effectiveness for reducing depression and increasing quality of life has been demonstrated in patients with coronary artery bypass grafting, type 2 diabetes, and the elderly...
October 16, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29033513/the-endothelial-nitric-oxide-synthase-nos3-786t-c-genetic-polymorphism-in-chronic-heart-failure-effects-of-mutant-786c-allele-on-long-term-mortality
#8
Sait Terzi, Ayşe Emre, Kemal Yesilcimen, Selçuk Yazıcı, Aysun Erdem, Ufuk Sadik Ceylan, Figen Ciloglu
BACKGROUND: Nitric oxide plays an important role in the regulation of basal vascular tone and cardiac myocyte function. We investigated the NOS3-786T>C polymorphism in chronic heart failure (CHF) and its effects on long-term mortality. METHODS: Ninety-one patients with CHF who were referred to the Department of Cardiology of Siyami Ersek Cardiovascular and Thoracic Surgery Center for cardiopulmonary exercise testing between April 2001 and January 2004 and 30 controls were enrolled in this study...
July 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29032034/therapeutic-investigations-of-novel-indoxyl-based-indolines-a-drug-target-validation-and-structure-activity-relationship-of-angiotensin-converting-enzyme-inhibitors-with-cardiovascular-regulation-and-thrombolytic-potential
#9
A Manikandan, Pearl Moharil, M Sathishkumar, C Muñoz-Garay, A Sivakumar
A family of 12 members of Naphthalene-2-ol-indolin-2-one-thiocarbamides (5a-l) with pharmacological potentials of cardiovascular modulator were efficiently synthesized and evaluated. These compounds show inhibitory activity on angiotensin-converting enzyme (ACE), which is a principal constituent of the renin-angiotensin system and causative source for hypertension (HTN) (elevated blood pressure) and congestive heart failure (CHF), a parameter that was tested in this report. Prior to this, to get more insight into the binding mode and inhibition of human ACE C-domain (PDB ID: 2XY9) and N-domain (PDB ID: 3NXQ) compounds 5a-l was docked into the active site of them...
October 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29025373/the-prognostic-value-of-high-sensitive-cardiac-troponin-i-in-patients-receiving-cardiac-resynchronisation-therapy
#10
Michal Kerekanič, Marek Hudák, Silvia Mišíková, Erika Komanová, Alexander Bohó, Ján Kyselovič, Branislav Stančák
BACKGROUND: Cardiac troponin I (cTnI) is a valuable prognostic biomarker in patients with chronic heart failure (CHF). However, the prognostic importance of cTnI in patients who received cardiac resynchronisation therapy (CRT) remains unknown. The aim of this prospective study was to determine the prognostic value of high-sensitive cTnI (hs-cTnI) in CHF patients receiving CRT. METHODS: We performed measurements of baseline hs-cTnI levels in CRT patients with ischaemic as well as nonischaemic aetiology of CHF, and we investigated their possible association with response to CRT and survival of patients...
October 12, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/29023738/klf2-mediates-enhanced-chemoreflex-sensitivity-disordered-breathing-and-autonomic-dysregulation-in-heart-failure
#11
Noah J Marcus, Rodrigo Del Rio, Yanfeng Ding, Harold D Schultz
KEY POINTS: Enhanced carotid body chemoreflex activity contributes to development of disordered breathing patterns, autonomic dysregulation and increases in incidence of arrhythmia in animal models of reduced ejection fraction heart failure. Chronic reductions in carotid artery blood flow are associated with increased carotid body chemoreceptor activity. Krüppel-like Factor 2 (KLF2) is a shear stress-sensitive transcription factor that regulates the expression of enzymes which have previously been shown to play a role in increased chemoreflex sensitivity...
September 6, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29021855/chads2-and-modified-cha2ds2-vasc-scores-for-the-prediction-of-congestive-heart-failure-in-patients-with-nonvalvular-atrial-fibrillation
#12
Yorihiko Koeda, Takashi Komatsu, Yuki Matsuura, Hidemi Morioka, Yohei Uchimura, Yuya Taguchi, Kentaro Tanaka, Jun Kawakami, Marie Nakamura, Shuko Takahashi, Yuji Takahashi, Yujiro Naganuma, Hiroshi Endo, Tatsuro Ito, Yoshihiro Morino, Motoyuki Nakamura
BACKGROUND & PURPOSE: We have conducted a retrospective observational study to analyze the correlation between the CHADS2 score, the modified CHA2DS2-VASc (mCHA2DS2-VASc) score, and the incidence of all-cause death and congestive heart failure (CHF). METHODS: The study cohort consisted of 292 consecutive patients with nonvalvular atrial fibrillation (NVAF) admitted to our hospital from 2012 to 2014. Electronic medical records were used to confirm medical history including prior heart failure, hypertension, diabetes, stroke, and coronary disease...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29020993/assessment-of-a-business-to-consumer-b2c-model-for-telemonitoring-patients-with-chronic-heart-failure-chf
#13
Andrija S Grustam, Hubertus J M Vrijhoef, Ron Koymans, Philipp Hukal, Johan L Severens
BACKGROUND: The purpose of this study is to assess the Business-to-Consumer (B2C) model for telemonitoring patients with Chronic Heart Failure (CHF) by analysing the value it creates, both for organizations or ventures that provide telemonitoring services based on it, and for society. METHODS: The business model assessment was based on the following categories: caveats, venture type, six-factor alignment, strategic market assessment, financial viability, valuation analysis, sustainability, societal impact, and technology assessment...
October 11, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29020031/sudden-cardiac-death-and-pump-failure-death-prediction-in-chronic-heart-failure-by-combining-ecg-and-clinical-markers-in-an-integrated-risk-model
#14
Julia Ramírez, Michele Orini, Ana Mincholé, Violeta Monasterio, Iwona Cygankiewicz, Antonio Bayés de Luna, Juan Pablo Martínez, Pablo Laguna, Esther Pueyo
BACKGROUND: Sudden cardiac death (SCD) and pump failure death (PFD) are common endpoints in chronic heart failure (CHF) patients, but prevention strategies are different. Currently used tools to specifically predict these endpoints are limited. We developed risk models to specifically assess SCD and PFD risk in CHF by combining ECG markers and clinical variables. METHODS: The relation of clinical and ECG markers with SCD and PFD risk was assessed in 597 patients enrolled in the MUSIC (MUerte Súbita en Insuficiencia Cardiaca) study...
2017: PloS One
https://www.readbyqxmd.com/read/29017565/safety-and-efficacy-of-qishen-granules-in-patients-with-chronic-heart-failure-study-protocol-for-a-randomized-controlled-trial
#15
Jinping Wang, Jun Shi, Jiawei Wei, Juan Wang, Kuo Gao, Xueli Li, Jianxin Chen, Shaojing Li, Huihui Zhao, Wei Wang
BACKGROUND: Chronic heart failure (CHF), the final stage of various cardiovascular diseases, is a major public health problem resulting in significant hospitalization rates, mortality, and huge health care costs despite advances in the treatment and management of heart failure and heart failure-related risk factors. Qishen granules (QSG), a Chinese herbal formula, is widely used by traditional Chinese medicine (TCM) practitioners to treat CHF. Several animal experimental studies have showed that QSG can significantly relieve the heart failure symptoms in CHF rat models...
October 10, 2017: Trials
https://www.readbyqxmd.com/read/29016817/association-between-socioeconomic-factors-and-icd-implantation-in-a-publicly-financed-health-care-system-a-danish-nationwide-study
#16
Matilde Winther-Jensen, Christian Hassager, Jens Flensted Lassen, Lars Køber, Christian Torp-Pedersen, Steen Møller Hansen, Freddy Lippert, Erika Frischknecht Christensen, Kristian Kragholm, Jesper Kjaergaard
Aims: For patients surviving out-of-hospital cardiac arrest (OHCA) with a shockable rhythm, implantable cardioverter defibrillator (ICD) is recommended for non-reversible causes of arrest. We aimed to determine factors associated with implantation of ICD and survival in patients surviving non-AMI OHCA in a nationwide register covering all OHCAs in Denmark. Methods and results: We identified 36 950 OHCAs between 2001 and 2012, 1700 of whom were ICD naïve, ≥18 years, of non-AMI cardiac aetiology and surviving until discharge...
August 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28993389/innovative-telemonitoring-enhanced-care-programme-for-chronic-heart-failure-itec-chf-to-improve-guideline-compliance-and-collaborative-care-protocol-of-a-multicentre-randomised-controlled-trial
#17
Hang Ding, Rajiv Jayasena, Andrew Maiorana, Alison Dowling, Sheau Huey Chen, Mohan Karunanithi, Jamie Layland, Iain Edwards
INTRODUCTION: Chronic heart failure (CHF) is a life-threatening chronic disease characterised by periodic exacerbations and recurrent hospitalisations. In the management of CHF, patient compliance with evidence-based clinical guidelines is essential, but remains difficult practically. The objective of this study is to examine whether an Innovative Telemonitoring Enhanced Care Programme for CHF (ITEC-CHF) improves patients' compliance, and associated health and economic outcomes. METHODS AND ANALYSIS: An open multicentre randomised controlled trial has been designed...
October 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28992690/atmospheric-chemistry-of-e-and-z-cf3ch%C3%A2-chf-hfo-1234ze-oh-reaction-kinetics-as-a-function-of-temperature-and-uv-and-ir-absorption-cross-sections
#18
María Antiñolo, Iván Bravo, Elena Jiménez, Bernabé Ballesteros, José Albaladejo
We report here the rate coefficients for the OH reactions (kOH) with E-CF3CH═CHF and Z-CF3CH═CHF, potential substitutes of HFC-134a, as a function of temperature (263-358 K) and pressure (45-300 Torr) by pulsed laser photolysis coupled to laser-induced fluorescence techniques. For the E-isomer, the existing discrepancy among previous results on the T dependence of kOH needs to be elucidated. For the Z-isomer, this work constitutes the first absolute determination of kOH. No pressure dependence of kOH was observed, while kOH exhibits a non-Arrhenius behavior: kOH(E) = [Formula: see text] and kOH(Z) = [Formula: see text] cm(3) molecule(-1) s(-1), where uncertainties are 2σ...
October 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28989893/an-intriguing-family-with-type-2-diabetes-mellitus-and-complete-heart-block
#19
Gaurav Agarwal, Satish Kumar Singh
Chronic hyperglycaemia of Type 2 Diabetes Mellitus (T2DM) causes long term damage to heart resulting in coronary artery disease (CAD), myocardial infarction (MI), congestive heart failure (CHF), and sudden death from arrhythmias. A 62 year old male presented to our emergency with complaint of sudden onset giddiness from last 2 hours. This was followed by loss of consciousness. Patient was a known case of T2DM since last 1 year. Family history- patient has two brothers who also have T2DM and both of them also developed Complete Heart Block (CHB) spontaneously...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28989880/arrhythmias-in-type-2-diabetes-mellitus
#20
Gaurav Agarwal, Satish Kumar Singh
Chronic hyperglycaemia of Type 2 diabetes mellitus causes long term damage to heart resulting in coronary artery disease (CAD), myocardial infarction (MI), congestive heart failure (CHF), and sudden death from arrhythmias. AIMS: To study the prevalence of different types of arrhythmias in T2DM, particularly in association with Cardiac Autonomic Neuropathy (CAN). METHODS: A cross-sectional study including 100 patients of Type 2 Diabetes Mellitus (T2DM) presenting with cardiac arrhythmias, was done at our hospital over 2 years...
September 2017: Indian Journal of Endocrinology and Metabolism
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