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https://www.readbyqxmd.com/read/28087308/myocardial-inotropic-reserve-an-old-twist-that-constitutes-a-reliable-index-in-the-modern-era-of-heart-failure
#1
REVIEW
Fragkiskos Parthenakis, Spyridon Maragkoudakis, Maria Marketou, Alexandros Patrianakos, Evaggelos Zacharis, Panos Vardas
Current national and international guidelines, including those of the European Society of Cardiology, recognize that the assessment of prognosis should be a part of the standard management for patients with chronic heart failure (CHF). However, these same guidelines recognize the inherent difficulty of this process. A variety of factors contribute to this difficulty, including the varying etiology, frequent co-morbidity and, perhaps most importantly, huge inter-individual variability in the disease progression and outcome...
November 22, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28079427/effect-of-functional-electrical-stimulation-on-cardiovascular-outcomes-in-patients-with-chronic-heart-failure
#2
Nikolaos Pe Kadoglou, Christina Mandila, Apostolos Karavidas, Dimitrios Farmakis, Vasiliki Matzaraki, Christos Varounis, Sofia Arapi, Anastasia Perpinia, John Parissis
Background/design Functional electrical stimulation of lower limb muscles is an alternative method of training in patients with chronic heart failure (CHF). Although it improves exercise capacity in CHF, we performed a randomised, placebo-controlled study to investigate its effects on long-term clinical outcomes. Methods We randomly assigned 120 patients, aged 71 ± 8 years, with stable CHF (New York Heart Association (NYHA) class II/III (63%/37%), mean left ventricular ejection fraction 28 ± 5%), to either a 6-week functional electrical stimulation training programme or placebo...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28076404/combined-inhibition-of-the-renin-angiotensin-system-and-neprilysin-positively-influences-complex-mitochondrial-adaptations-in-progressive-experimental-heart-failure
#3
Laura Grois, Julian Hupf, Jörg Reinders, Josef Schröder, Alexander Dietl, Peter M Schmid, Carsten Jungbauer, Markus Resch, Lars S Maier, Andreas Luchner, Christoph Birner
BACKGROUND: Inhibitors of the renin angiotensin system and neprilysin (RAS-/NEP-inhibitors) proved to be extraordinarily beneficial in systolic heart failure. Furthermore, compelling evidence exists that impaired mitochondrial pathways are causatively involved in progressive left ventricular (LV) dysfunction. Consequently, we aimed to assess whether RAS-/NEP-inhibition can attenuate mitochondrial adaptations in experimental heart failure (HF). METHODS AND RESULTS: By progressive right ventricular pacing, distinct HF stages were induced in 15 rabbits, and 6 animals served as controls (CTRL)...
2017: PloS One
https://www.readbyqxmd.com/read/28076358/a-randomized-trial-examining-housing-first-in-congregate-and-scattered-site-formats
#4
Julian M Somers, Akm Moniruzzaman, Michelle Patterson, Lauren Currie, Stefanie N Rezansoff, Anita Palepu, Karen Fryer
OBJECTIVE: No previous experimental trials have investigated Housing First (HF) in both scattered site (SHF) and congregate (CHF) formats. We hypothesized that CHF and SHF would be associated with a greater percentage of time stably housed as well as superior health and psychosocial outcomes over 24 months compared to treatment as usual (TAU). METHODS: Inclusion criteria were homelessness, mental illness, and high need for support. Participants were randomised to SHF, CHF, or TAU...
2017: PloS One
https://www.readbyqxmd.com/read/28075423/effects-of-device-guided-slow-breathing-training-on-exercise-capacity-cardiac-function-and-respiratory-patterns-during-sleep-in-male-and-female-patients-with-chronic-heart-failure
#5
Kalina Kawecka-Jaszcz, Grzegorz Bilo, Tomasz Drożdż, Dorota Dębicka-Dąbrowska, Grzegorz Kiełbasa, Gabriella Malfatto, Katarzyna Styczkiewicz, Carolina Lombardi, Agnieszka Bednarek, Sabrina Salerno, Danuta Czarnecka, Gianfranco Parati
INTRODUCTION    Slow breathing training (SBT) has been proposed as new non-pharmacological treatment in chronic heart failure (CHF) patients.  OBJECTIVES    The aim of this study was to assess the effects of SBT on exercise capacity, haemodynamic parameters and sleep respiratory patterns in a relatively large sample of CHF patients. PATIENTS ABD METHODS    A cross-over open study was conducted. The patients completed, in random order, 10-12 week periods of SBT with the RESPeRATE device (InterCure Ltd...
January 10, 2017: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/28071901/accurate-theoretical-thermochemistry-for-fluoroethyl-radicals
#6
Adam Ganyecz, Mihaly Kallay, Jozsef Csontos
An accurate coupled-cluster (CC) based model chemistry was applied to calculate reliable thermochemical quantities for hydrofluorocarbon hydrofluorocarbon derivatives including radicals 1-fluoroethyl (CH3 -CHF), 1,1-difluoroethyl (CH3-CF2), 2-fluoroethyl (CH2F-CH2), 1,2-difluoroethyl (CH2F-CHF), 2,2-difluoroethyl (CHF2-CH2), 2,2,2-trifluoroethyl (CF3-CH2), 1,2,2,2-tetrafluoroethyl (CF3-CHF), and pentafluoroethyl (CF3-CF2). The model chemistry used contains iterative triple and perturbative quadruple excitations in CC theory, as well as scalar relativistic and diagonal Born-Oppenheimer corrections...
January 10, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28069473/high-intensity-training-improves-global-and-segmental-strains-in-severe-congestive-heart-failure
#7
Yair Blumberg, Offir Ertracht, Itai Gershon, Noa Bachner-Hinenzon, Tali Reuveni, Shaul Atar
BACKGROUND: High intensity training (HIT) is superior to moderate aerobic training (MAT) for improving quality of life in congestive heart failure (CHF) patients. Speckle tracking echocardiography (STE) has recently been suggested for estimation of left ventricle global and regional function. AIMS: We evaluated the utility of STE for characterizing differences in cardiac function following MAT or HIT in a CHF rat model. METHODS AND RESULTS: Following baseline physiological assessment, CHF was induced by coronary artery ligation in Sprague-Dawley rats...
January 6, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28068279/identifying-predictors-of-central-sleep-apnea-cheyne-stokes-breathing-in-chronic-heart-failure-a-pathophysiological-approach
#8
Aneliya I Draganova, Kiril V Terziyski, Stefan S Kostianev
Chronic heart failure (CHF) is a major health problem associated with increased mortality, despite modern treatment options. Central sleep apnea (CSA)/Cheyne-Stokes breathing (CSB) is a common and yet largely under-diagnosed co-morbidity, adding significantly to the poor prognosis in CHF because of a number of acute and chronic effects, including intermittent hypoxia, sympathetic overactivation, disturbed sleep architecture and impaired physical tolerance. It is characterized by repetitive periods of crescendo-decrescendo ventilatory pattern, alternating with central apneas and hypopneas...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28067533/frequent-coexistence-of-chronic-heart-failure-and-chronic-obstructive-pulmonary-disease-in-respiratory-and-cardiac-outpatients-evidence-from-suspirium-a-multicentre-italian-survey
#9
Raffaele Griffo, Antonio Spanevello, Pier Luigi Temporelli, Pompilio Faggiano, Mauro Carone, Giovanna Magni, Nicolino Ambrosino, Luigi Tavazzi
Background Chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) frequently coexist but concurrent COPD + CHF has been little investigated. Design This multicentre survey (SUSPIRIUM) was designed to evaluate: the prevalence of COPD in stable CHF and CHF in stable COPD; diagnostic/therapeutic work-up for concurrent COPD + CHF; clinical profile of patients with COPD + CHF; predictors of COPD in CHF and CHF in COPD. Methods A 5-month-long cross-sectional prospective observational survey was conducted in 10 cardiac and 10 respiratory connected outpatient units...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28066918/implementation-of-the-redesigned-community-health-fund-in-the-dodoma-region-of-tanzania-a-qualitative-study-of-views-from-rural-communities
#10
Albino Kalolo, Lara Gautier, Ralf Radermacher, Manfred Stoermer, Albrecht Jahn, Menoris Meshack, Manuela De Allegri
The need to understand how an intervention is received by the beneficiary community is well recognised and particularly neglected in the micro-health insurance (MHI) domain. This study explored the views and reactions of the beneficiary community of the redesigned Community Health Fund (CHF) implemented in the Dodoma region of Tanzania. We collected data from focus group discussions with 24 groups of villagers (CHF members and nonmembers) and in-depth interviews with 12 key informants (enrolment officers and health care workers)...
January 8, 2017: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/28062372/uric-acid-may-be-protective-against-cognitive-impairment-in-older-adults-but-only-in-those-without-cardiovascular-risk-factors
#11
Busra Tuven, Pinar Soysal, Gulcin Unutmaz, Derya Kaya, Ahmet Turan Isik
Uric acid (UA) may not only prevent development of cognitive dysfunction owing to its antioxidant efficacy, but also may worsen cognitive functions by gaining pro-oxidant character. The present study attempts to uncover this paradoxical association between UA and cognitive impairment in elderly. 1374 elderly patients were retrospectively evaluated and included in the study. Participants underwent determination of circulating UA levels and comprehensive geriatric assessment. A serum UA concentration≥7.0mg/dL in males and ≥5...
January 3, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28057850/investigation-of-the-link-between-fluid-shift-and-airway-collapsibility-as-a-mechanism-for-obstructive-sleep-apnea-in-congestive-heart-failure
#12
Tom Carlisle, Neil R Ward, Angela Atalla, Martin R Cowie, Anita K Simonds, Mary J Morrell
The increased prevalence of obstructive sleep apnea (OSA) in congestive heart failure (CHF) may be associated with rostral fluid shift. We investigated the effect of overnight rostral fluid shift on pharyngeal collapsibility (Pcrit), pharyngeal caliber (APmean), and apnea-hypopnea index (AHI) in CHF patients. Twenty-three optimally treated systolic CHF patients were studied. Neck circumference was measured immediately prior to sleep in the evening and immediately after waking in the morning as a marker of rostral fluid shift...
January 2017: Physiological Reports
https://www.readbyqxmd.com/read/28057245/alcohol-abuse-and-cardiac-disease
#13
Isaac R Whitman, Vratika Agarwal, Gregory Nah, Jonathan W Dukes, Eric Vittinghoff, Thomas A Dewland, Gregory M Marcus
BACKGROUND: Understanding the relationship between alcohol abuse, a common and theoretically modifiable condition, and the most common cause of death in the world, cardiovascular disease, may inform potential prevention strategies. OBJECTIVES: The study sought to investigate the associations among alcohol abuse and atrial fibrillation (AF), myocardial infarction (MI), and congestive heart failure (CHF). METHODS: Using the Healthcare Cost and Utilization Project database, we performed a longitudinal analysis of California residents ≥21 years of age who received ambulatory surgery, emergency, or inpatient medical care in California between 2005 and 2009...
January 3, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28055049/clinical-outcomes-of-metformin-use-in-populations-with-chronic-kidney-disease-congestive-heart-failure-or-chronic-liver-disease-a-systematic-review
#14
Matthew J Crowley, Clarissa J Diamantidis, Jennifer R McDuffie, C Blake Cameron, John W Stanifer, Clare K Mock, Xianwei Wang, Shuang Tang, Avishek Nagi, Andrzej S Kosinski, John W Williams
Background: Recent changes to the U.S. Food and Drug Administration boxed warning for metformin will increase its use in persons with historical contraindications or precautions. Prescribers must understand the clinical outcomes of metformin use in these populations. Purpose: To synthesize data addressing outcomes of metformin use in populations with type 2 diabetes and moderate to severe chronic kidney disease (CKD), congestive heart failure (CHF), or chronic liver disease (CLD) with hepatic impairment...
January 3, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28054808/cognitive-impairment-in-heart-failure-a-protective-role-for-angiotensin-1-7
#15
Meredith Hay, Todd W Vanderah, Farmin Samareh-Jahani, Eleni Constantopoulos, Ajay R Uprety, Carol A Barnes, John Konhilas
Patients with congestive heart failure (CHF) have increased hospital readmission rates and mortality if they are concomitantly diagnosed with cognitive decline and memory loss. Accordingly, we developed a preclinical model of CHF-induced cognitive impairment with the goal of developing novel protective therapies against CHF related cognitive decline. CHF was induced by ligation of the left coronary artery to instigate a myocardial infarction (MI). By 4- and 8-weeks post-MI, CHF mice had approximately a 50% and 70% decline in ejection fraction as measured by echocardiography...
January 5, 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28052703/a-client-centred-programme-focusing-energy-conservation-for-people-with-heart-failure
#16
Eva-Britt Norberg, Britta Löfgren, Kurt Boman, Patrik Wennberg, Margareta Brännström
AIM: The purpose of this study was to describe clients and occupational therapists (OTs) experiences of a home-based programme focusing energy conservation strategies (ECS) for clients with chronic heart failure (CHF). METHODS: The programme, based on occupational therapy intervention process model (OTIPM), was led by two OTs in primary health care. Five clients' self-reported activities of daily living (ADL), fatigue, depression, goal achievements and use of ECS...
January 5, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28041705/using-coronary-calcification-to-exclude-an-ischemic-etiology-for-cardiomyopathy-a-validation-study-and-systematic-review
#17
Manuja Premaratne, Mohabbat Shamsaei, Jonathan D H Chow, Tony Haddad, Fernanda Erthal, Helen Curran, Yeung Yam, Agnieszka Szczotka, Lisa Mielniczuk, George A Wells, Rob S Beanlands, Alomgir Hossain, Benjamin J W Chow
BACKGROUND: Preliminary data suggests the absence of coronary artery calcification (CAC) excludes ischemic etiologies of cardiomyopathy. We prospectively validate and perform a systematic review to determine the utility of an Agatston score=0 to exclude the diagnosis of ischemic cardiomyopathy. METHODS AND RESULTS: Patients with newly diagnosed LV dysfunction were prospectively enrolled. Patients underwent CAC imaging and were followed until an etiologic diagnosis of cardiomyopathy was made...
December 20, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28040872/cost-effectiveness-of-conservative-versus-surgical-treatment-strategies-of-lumbar-spinal-stenosis-in-the-swiss-setting-analysis-of-the-prospective-multicenter-lumbar-stenosis-outcome-study-lsos
#18
A Aichmair, J M Burgstaller, M Schwenkglenks, J Steurer, F Porchet, F Brunner, M Farshad
PURPOSE: To evaluate the cost-effectiveness of conservative versus surgical treatment strategies for lumbar spinal stenosis (LSS). METHODS: Patients prospectively enrolled in the multicenter Lumbar Stenosis Outcome Study (LSOS) with a minimum follow-up of 12 months were included. Quality adjusted life years (QALY) were calculated based on EQ-5D data. Cost data were retrieved retrospectively. Cost-effectiveness was calculated via decision tree analysis. RESULTS: A total of 434 patients were included, treated surgically (n = 170) or conservatively (n = 264) for LSS...
December 31, 2016: European Spine Journal
https://www.readbyqxmd.com/read/28033163/a-retrospective-comparison-of-home-telehealth-and-nursing-care-with-or-without-rehabilitation-therapy-on-rehospitalization-rates-of-individuals-with-heart-failure
#19
Stacy Martin, Bill Anderson, Jennifer L Vincenzo, Sajid Yousuf Zai
PURPOSE: Congestive heart failure (CHF) is the most common reason for rehospitalization among the aging population, accounting for one-fifth of all hospital admissions. To date, there is no research comparing the rehospitalization rates between patients with CHF (PWCHF) who receive telehealth and home health nursing care versus a multidisciplinary team consisting of telehealth, home nursing, physical therapy (PT), and/or occupational therapy (OT). METHODS: A retrospective analysis was performed with 132 Medicare Part A home health patients discharged from an inpatient setting with a primary or secondary diagnosis of CHF receiving daily telehealth over the course of 1 year...
December 28, 2016: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28032902/population-pharmacokinetics-of-eplerenone-in-japanese-patients-with-chronic-heart-failure
#20
Masayo Oishi, Yoshiro Tomono, Qinying Zhao, Kevin Sweeney
To characterize eplerenone pharmacokinetics (PK) in Japanese chronic heart failure (CHF) patients and to estimate the impact of factors that may affect eplerenone PK, population pharmacokinetic (PPK) analysis was conducted. In addition, PK of Japanese CHF and Western CHF patients from a previous clinical pharmacology study were compared in the analysis. Eplerenone PK was characterized by a 1-compartment PPK model with first-order absorption and lag time in Japanese CHF patients. The population mean of apparent oral clearance (CL/F) in Japanese CHF patients was estimated as 5...
December 29, 2016: Journal of Clinical Pharmacology
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