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https://www.readbyqxmd.com/read/29342246/associations-of-quadriceps-torque-properties-with-muscle-size-attenuation-and-intra-muscular-adipose-tissue-in-older-adults
#1
Andrew W Frank-Wilson, Didier Chalhoub, Pedro Figueiredo, Pálmi V Jónsson, Kristín Siggeirsdóttir, Sigurdur Sigurdsson, Gudny Eiriksdottir, Vilmundur Guðnason, Lenore Launer, Tamara B Harris
Background: Atrophy and fatty infiltration of muscle with aging are associated with fractures and falls, however, their direct associations with muscle function are not well described. It was hypothesized that participants with lower quadriceps muscle attenuation, area, and greater intra-muscular adipose tissue (IMAT) will exhibit slower rates of torque development (RTD) and lower peak knee extension torques. Methods: Data from 4842 participants (2041 men, 2801 women) from the Age Gene/Environment Susceptibility Reykjavik Study (mean age 76±0...
January 12, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29342112/useful-bicistronic-reporter-system-for-studying-poly-a-site-defining-cis-elements-and-regulation-of-alternative-polyadenylation
#2
Zhongyuan Deng, Shen Zhang, Shaohua Gu, Xinzhi Ni, Wenxian Zeng, Xianchun Li
The link between polyadenylation (pA) and various biological, behavioral, and pathological events of eukaryotes underlines the need to develop in vivo polyadenylation assay methods for characterization of the cis-acting elements, trans-acting factors and environmental stimuli that affect polyadenylation efficiency and/or relative usage of two alternative polyadenylation (APA) sites. The current protein-based CAT or luciferase reporter systems can measure the polyadenylation efficiency of a single pA site or candidate cis element but not the choice of two APA sites...
January 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29341486/rheumatoid-arthritis-and-periodontal-disease-what-are-the-similarities-and-differences
#3
REVIEW
Rongbin Li, Cheng Tian, Arnold Postlethwaite, Yan Jiao, Franklin Garcia-Godoy, Debendra Pattanaik, Dongmei Wei, Weikuan Gu, Jianwei Li
Rheumatoid arthritis (RA) and periodontal disease (PD) are chronic inflammatory diseases that share similar osteoclasia, human leukocyte antigen-DR4 allelic genes and immunological profile, and characteristic cytokines. Smoking can contribute to more severe RA and PD; secretion of pro-inflammatory mediators destroys the soft synovial membrane and periodontium, respectively. Anti-citrullinated protein antibodies and anti-α-enolase antibody are characteristic of these two diseases. Some studies suggest that PD may be associated with RA...
December 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29341459/multicenter-study-of-diagnostic-procedures-genetic-aberration-analysis-and-first-line-treatment-of-lung-cancer-in-jiangsu-province-china
#4
YangBo Hu, Huan Hu, LiYun Miao, Xin Zhao, Wei Gu, Wei Heng, ZiLi Meng, Jian Feng, Yi You, XingXiang Xu, Rong Hu, HaiQuan Li, Jie Zhao, XiaoLi Zhu, MeiQi Shi, Li Shen, XiuWei Zhang, XiaoWei Yin, Hang Ma, MinHua Shi, Yong Yu, Hong Lv, LiMing Cai, GaoHua Feng, YeQing Zhang, Feng Wu, TangFeng Lv, Yong Song
BACKGROUND: Jiangsu Province, China, is highly developed economically and culturally, and has a high prevalence of lung cancer. We aimed to evaluate the diagnostic procedures, genetic aberration analysis status, and first-line treatment models of lung cancer in Jiangsu Province. METHODS: Lung cancer patients diagnosed in 2016 at 22 tertiary care hospitals were evaluated. Demographic characteristics, tumor histology, staging, family history of lung cancer, auxiliary examinations, genetic testing, and first-line treatment were collected on discharge...
January 17, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29341436/a-novel-nir-fluorescent-probe-for-monitoring-cox-2-in-inflammation-and-tumor
#5
Qi Zhang, Zhihao Han, Ji Tao, Wancun Zhang, Ping Li, Liping Tang, Yueqing Gu
Targeting COX-2 for molecular imaging is an attractive approach applicable for its overexpression in inflammation and many malignancies. Herein, for monitoring COX-2, we synthesize a specific COX-2 probe CMP, based on celecoxib and a water-soluble near-infrared dye MPA. Its high affinity for binding to COX-2 is verified by molecular docking, dynamics simulation and inhibition assay. At cellular level, CMP selectively accumulates in cytoplasm of COX-2-positive cells. In vivo assays, probe guided-imaging in inflamed or cancerous tissues confirms that CMP can bind to the locally endogenic COX-2 and exhibit intense fluorescence...
January 17, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29341259/child-syndrome-mimicking-verrucous-nevus-in-a-chinese-patient-responded-well-to-the-topical-therapy-of-compound-of-simvastatin-and-cholesterol
#6
Xia Yu, Jia Zhang, Yan Gu, Dan Deng, Zhouwei Wu, Lei Bao, Ming Li, Zhirong Yao
BACKGROUND: Congenital hemidysplasia with ichthyosiform erythroderma and limb defects (CHILD) syndrome is a rare X-linked dominant disorder characterized by peculiar cutaneous presentations and ipsilateral skeletal abnormalities. CHILD syndrome is caused by mutations in NSDHL gene, which involves in cholesterol synthesis. OBJECTIVES: To verify the diagnosis of CHILD syndrome and seek effective pathogenesis-based therapy with little side effects. METHOD: We comprehensively evaluated the patient's conditions...
January 17, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29340437/a-novel-lysosome-targeted-fluorogenic-probe-based-on-5-triazole-quinoline-for-the-rapid-detection-of-hydrogen-sulfide-in-living-cells
#7
Yandong Dou, Xiaoxu Gu, Shasha Ying, Shen Zhu, Shian Yu, Wei Shen, Qing Zhu
A fluorogenic probe based on the novel fluorophore 5-triazole-quinoline was developed for the detection of hydrogen sulfide, an endogenous signaling molecule associated with the development of various diseases. The lysosome-targeted probe Lyso-HS was synthesized via C-H direct azidation from 8-aminoquinoline; it was able to detect H2S in 1 min and exhibited excellent turn-on ability with 95-fold fluorescence enhancement based on a new fluorochrome. The high quenching efficiency was further verified using time-dependent density functional theory (TDDFT)...
January 17, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29340111/effect-of-dihydropyrimidine-dehydrogenase-single-nucleotide-polymorphisms-on-prognosis-of-breast-cancer-patients-with-chemotherapy
#8
Fengxia Qin, Huikun Zhang, Yong Huang, Limin Yang, Feng Yu, Xiaoli Liu, Li Fu, Feng Gu, Yongjie Ma
Defining biomarkers that predict therapeutic effects and adverse events is a crucial mandate to guide patient selection for personalized cancer treatments. DPD (dihydropyrimidine dehydrogenase, encoded by DPYD gene) is the initial and rate-limiting enzyme of metabolic pathway of fluoropyrimidines, and fluoropyrimidines are common used drug therapies for breast cancer. Previous studies on DPYD polymorphism were mainly focused on its association with fluoropyrimidines toxicity. In our present study, 5 DPYD single nucleotide polymorphisms status was detected from tumor tissues of 331 invasive breast cancer patients using standard techniques...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29340098/icam-1-regulates-macrophage-polarization-by-suppressing-mcp-1-expression-via-mir-124-upregulation
#9
Wei Gu, Lun Yao, Lexing Li, Jianping Zhang, Aaron T Place, Richard D Minshall, Guoquan Liu
Intercellular adhesion molecule-1 is the adhesion molecule mediating leukocyte firm adhesion to endothelial cells, plays a critical role in subsequent leukocyte transmigration. ICAM-1 is also expressed in other cells including macrophages; however, the role of this adhesion molecule in mediating macrophage functions remains enigmatic. We report that ICAM-1 regulates macrophage polarization by positively modulating miR-124 expression. We found higher expression levels of monocyte chemotactic protein-1 in lungs of mice lacking ICAM-1...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29340036/the-association-between-elevated-fasting-plasma-glucose-levels-and-carotid-intima-media-thickness-in-non-diabetic-adults-a-population-based-cross-sectional-study
#10
Yalin Guan, Changshen Yu, Min Shi, Jingxian Ni, Yanan Wu, Hongfei Gu, Lingling Bai, Jie Liu, Jun Tu, Jinghua Wang, Xianjia Ning
We assessed the association between the mean carotid intima-media thickness (CIMT) and fasting plasma glucose (FPG) levels in a low-income population in rural China. Adults aged ≥45 years without a history of diabetes, stroke, or cardiovascular disease were recruited. All participants were categorized into four groups according to FPG level. A total of 3509 participants were analyzed in this study. In the univariate analysis, sex, age, education level, hypertension, central obesity, current smoking, alcohol consumption, and higher levels of FPG, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were associated with mean CIMT and frequency of increased CIMT...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339734/au-nb-h-x-k1-xnbo3-nanopeapods-with-near-infrared-active-plasmonic-hot-electron-injection-for-water-splitting
#11
Ying-Chu Chen, Yu-Kuei Hsu, Radian Popescu, Dagmar Gerthsen, Yan-Gu Lin, Claus Feldmann
Full-spectrum utilization of diffusive solar energy by a photocatalyst for environmental remediation and fuel generation has long been pursued. In contrast to tremendous efforts in the UV-to-VIS light regime of the solar spectrum, the NIR and IR areas have been barely addressed although they represent about 50% of the solar flux. Here we put forward a biomimetic photocatalyst blueprint that emulates the growth pattern of a natural plant-a peapod-to address this issue. This design is exemplified via unidirectionally seeding core-shell Au@Nb nanoparticles in the cavity of semiconducting H x K1-xNbO3 nanoscrolls...
January 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29339572/three-dimensional-cross-linking-composite-of-graphene-carbon-nanotube-and-si-nanoparticles-for-lithium-ion-batteries-anode
#12
Suyun Tian, Guannan Zhu, Yanping Tang, Xiaohua Xie, Qian Wang, Yufei Ma, Gu Qiao Ding, Xiaoming Xie
Various graphene-based Si nanocomposites have been reported to improve the performance of active materials in Li ion battery. However, these candidates still yield severe capacity fading due to the electrical disconnection and fracture caused by huge volume changes with extended cycles.Therefore, we design a novel three-dimensional cross-linking structure of graphene and single-wall carbon nanotube to encapsulate Si nanoparticles. The synthesized three-dimensional structure is ascribed to the excellent self-assembly of carbon nanotube with graphene oxide and a thermal treatment process at 900 ºC...
January 17, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29339121/hsf1-in-association-with-morc2-downregulates-argbp2-via-the-prc2-family-in-gastric-cancer-cells
#13
Yuxin Tong, Yan Li, Hui Gu, Chunyu Wang, Funan Liu, Yangguang Shao, Feng Li
Arg Kinase-binding protein 2 (ArgBP2) is considered to be a scaffold protein that coordinates multiple signaling pathways converging on cell adhesion and actin cytoskeletal organization. It also plays an important role in blocking cancer metastasis as a potential tumor suppressor. However, its regulation mechanisms in tumor migration, especially in gastric cancer, are not fully understood. Here, we identified an ArgBP2 enhancer and showed that heat shock factor 1 (HSF1) directly interacted with microrchidia CW-type zinc finger 2 (MORC2) and bound to the enhancer of ArgBP2...
January 12, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29338745/study-of-correlation-between-wall-shear-stress-and-elasticity-in-atherosclerotic-carotid-arteries
#14
Bo Zhang, Junyi Gu, Ming Qian, Lili Niu, Dhanjoo Ghista
OBJECTIVE: This paper presents the use of the texture matching method to measure the rabbit carotid artery elasticity value of the experimental group and control group respectively. It compares the experimental rabbits, when they are prompted by pathological histology to be at the period of carotid atherosclerosis fatty streaks and fiber plaques, with the control group. METHODS: We have used ultrasound linear array probe for scanning the rabbit carotid arteries...
January 16, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29338305/safety-and-feasibility-of-prostate-stereotactic-ablative-radiotherapy-using-multi-modality-imaging-and-flattening-filter-free
#15
Aileen Duffton, Azmat Sadozye, Lynsey Devlin, Nicholas MacLeod, Carolynn Lamb, Suzanne Smith, Philip McLoone, Muthu Sankaralingam, John Foster, Stephanie Paterson, Stefanie Keatings, David Dodds
PURPOSE: To investigate feasibility and safety of SABR in the management of prostate cancer while employing MR/CT fusion for delineation, fiducial markers seeds for positioning and Varian Rapidarc with FFF delivery. METHODS: Forty-one patients were treated for low-intermediate risk prostate cancer with initial PSA (iPSA) of ≤20ng/ml, Gleason score 6-7. Patients had MR/CT fusion for delineation of prostate +/-seminal vesicles. CT/MR fusion images were used for delineation and planned using flattening filter free modality...
January 17, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29338202/nanoscale-domain-imaging-of-all-polymer-organic-solar-cells-by-photo-induced-force-microscopy
#16
Kevin L Gu, Yan Zhou, William A Morrison, Katherine Park, Sung Park, Zhenan Bao
Rapid nanoscale imaging of the bulk heterojunction layer in organic solar cells is essential to the continued development of high-performance devices. Unfortunately, commonly used imaging techniques such as tunneling electron microscopy (TEM) and atomic force microscopy (AFM) suffer from significant drawbacks. For instance, assuming domain identity from phase contrast or topographical features can lead to inaccurate morphological conclusions. Here we demonstrate a technique known as Photo-induced Force Microscopy (PiFM) for imaging organic solar cell bulk heterojunctions with nanoscale chemical specificity...
January 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/29337894/inclinometer-assembly-error-calibration-and-horizontal-image-correction-in-photoelectric-measurement-systems
#17
Xiaofang Kong, Qian Chen, Jiajie Wang, Guohua Gu, Pengcheng Wang, Weixian Qian, Kan Ren, Xiaotao Miao
Inclinometer assembly error is one of the key factors affecting the measurement accuracy of photoelectric measurement systems. In order to solve the problem of the lack of complete attitude information in the measurement system, this paper proposes a new inclinometer assembly error calibration and horizontal image correction method utilizing plumb lines in the scenario. Based on the principle that the plumb line in the scenario should be a vertical line on the image plane when the camera is placed horizontally in the photoelectric system, the direction cosine matrix between the geodetic coordinate system and the inclinometer coordinate system is calculated firstly by three-dimensional coordinate transformation...
January 16, 2018: Sensors
https://www.readbyqxmd.com/read/29337619/the-role-of-necroptosis-apoptosis-and-inflammation-in-fowl-cholera-associated-liver-injury-in-a-chicken-model
#18
Qiyu Tang, Weitian Li, Na Dai, Yiming Gao, Yu Han, Guofu Cheng, Changqin Gu
Fowl cholera resulting from infection with Pasteurella multocida causes huge economic losses in the poultry industry. Necrotic hepatitis is reported to be a significant lesion associated with fowl cholera in chickens. Clarifying the underlying molecular mechanism of hepatic injury caused by P. multocida infection is needed to develop new strategies to control fowl cholera. Pasteurella multocida Q (the standard reference strain) and P. multocida 1G1 (a clinical strain) were used to infect healthy laying hens...
December 2017: Avian Diseases
https://www.readbyqxmd.com/read/29337222/blockade-of-placental-growth-factor-reduces-vaso-occlusive-complications-in-murine-models-of-sickle-cell-disease
#19
Jian-Ming Gu, Shujun Yuan, Derek Sim, Keith Abe, Perry Liu, Martin Rosenbruch, Peter Bringmann, Katalin Kauser
Vaso-occlusive crisis (VOC) is the most common and debilitating complication of sickle cell disease (SCD); recurrent episodes cause organ damage and contribute to early mortality. Plasma placental growth factor (PlGF) levels are elevated in SCD and can further increase under hypoxic conditions in SCD mice. Treatment with a PlGF-neutralizing antibody (anti-PlGF Ab) in SCD mice reduced levels of monocyte chemoattractant protein-3, eotaxin, macrophage colony-stimulating factor, plasminogen activator inhibitor-1 significantly, and macrophage-derived chemokine and macrophage inflammatory protein-3β moderately; this may contribute to inhibition of leukocyte recruitment, activation, and thrombosis...
January 11, 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29337215/anti-angiogenic-effects-of-qingdu-granule-on-breast-cancer-through-inhibiting-nfat-signaling-pathway
#20
Xin Zhao, Jinyu Liu, Lili Feng, Shasha Ge, Shijun Yang, Chen Chen, Xiaoya Li, Lin Peng, Yuxue Mu, Yueqi Wang, Daozhao Gu, Yi Guo, Geng Lin, Bo Deng, Zhiqiang Cheng, Dayong Cai
ETHNOPHARMACOLOGICAL RELEVANCE: Qingdu granule (QDG), a traditional Chinese herbal prescription, had anti-tumor effect on breast cancer. However the underlying mechanism of QDG was unclear. THE AIM OF THIS STUDY: The present study aimed to investigate whether QDG could inhibit angiogenesis of breast cancer via acting on nuclear factor of activated T-cells (NFAT) signaling pathway. This was implicated in human umbilical vein endothelial cells (HUVECs) in vitro and breast cancer xenograft model in vivo...
January 11, 2018: Journal of Ethnopharmacology
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