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https://www.readbyqxmd.com/read/28817829/altered-expression-profile-of-circular-rnas-in-the-serum-of-patients-with-diabetic-retinopathy-revealed-by-microarray
#1
Yonghao Gu, Genjie Ke, Lin Wang, Enliang Zhou, Kai Zhu, Yingying Wei
PURPOSE: Diabetic retinopathy (DR) is the leading cause of blindness among working age adults. Circular RNAs (circRNAs) are a kind of noncoding RNAs that are involved in the development of some diseases. Here, we aimed to determine the possible role of circRNAs in the pathogenesis of DR by determining the expression profile of circRNAs in the serum of DR patients. METHODS: Nineteen subjects with type 2 diabetes mellitus with proliferative DR (T2DR), 15 subjects with type 2 diabetes mellitus without DR (T2DM), and 21 age-matched nondiabetic control subjects were included in the study...
August 18, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28817807/mir-21-promotes-cardiac-fibrosis-after-myocardial-infarction-via-targeting-smad7
#2
Jinxia Yuan, Hongtao Chen, Dawei Ge, Yu Xu, Haihua Xu, Yang Yang, Ming Gu, Yuhe Zhou, Jingdong Zhu, Ting Ge, Qun Chen, Yue Gao, Yanqing Wang, Xiaowei Li, Yanfang Zhao
BACKGROUND/AIMS: Cardiac fibrosis after myocardial infarction (MI) has been identified as an important factor in the deterioration of heart function. Previous studies have demonstrated that miR-21 plays an important role in various pathophysiological processes in the heart. However, the role of miR-21 in fibrosis regulation after MI remains unclear. METHODS: To induce cardiac infarction, the left anterior descending coronary artery was permanently ligated of mice...
August 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28817801/a-sensitized-igf1-treatment-restores-corticospinal-axon-dependent-functions
#3
Yuanyuan Liu, Xuhua Wang, Wenlei Li, Qian Zhang, Yi Li, Zicong Zhang, Junjie Zhu, Bo Chen, Philip R Williams, Yiming Zhang, Bin Yu, Xiaosong Gu, Zhigang He
A major hurdle for functional recovery after both spinal cord injury and cortical stroke is the limited regrowth of the axons in the corticospinal tract (CST) that originate in the motor cortex and innervate the spinal cord. Despite recent advances in engaging the intrinsic mechanisms that control CST regrowth, it remains to be tested whether such methods can promote functional recovery in translatable settings. Here we show that post-lesional AAV-assisted co-expression of two soluble proteins, namely insulin-like growth factor 1 (IGF1) and osteopontin (OPN), in cortical neurons leads to robust CST regrowth and the recovery of CST-dependent behavioral performance after both T10 lateral spinal hemisection and a unilateral cortical stroke...
August 16, 2017: Neuron
https://www.readbyqxmd.com/read/28817188/changes-in-standardized-mortality-rates-from-thyroid-cancer-in-korea-between-1985-and-2015-analysis-of-korean-national-data
#4
Yun Mi Choi, Won Gu Kim, Hyemi Kwon, Min Ji Jeon, Minkyu Han, Tae Yong Kim, Young Kee Shong, Sang Mo Hong, Eun-Gyoung Hong, Won Bae Kim
BACKGROUND: The incidence of thyroid cancer has increased very rapidly in Korea; however, most previous studies suggested that the mortality rate for thyroid cancer remained stable. The objective of the current study was to evaluate recent changes in standardized thyroid cancer mortality using data from Statistics Korea. METHODS: Population and mortality data from 1985 through 2015 were obtained from Statistics Korea. Age-standardized mortality rates (ASMRs) from thyroid cancer per 100,000 population were calculated based on the World Health Organization standard population...
August 17, 2017: Cancer
https://www.readbyqxmd.com/read/28816967/hand-assisted-laparoscopic-surgery-versus-conventional-open-surgery-in-intraoperative-and-postoperative-outcomes-for-colorectal-cancer-an-updated-systematic-review-and-meta-analysis
#5
Xubing Zhang, Qingbin Wu, Chaoyang Gu, Tao Hu, Liang Bi, Ziqiang Wang
AIM: This meta-analysis aims to compare hand-assisted laparoscopic surgery (HALS) and conventional open surgery (OS) for colorectal cancer (CRC) in terms of intraoperative and postoperative outcomes, and to explore the safety, feasibility of HALS for CRC surgery. METHODS: A systematic literature search with no limits was performed in PubMed, Embase, and Medline. The last search was performed on April 23, 2017. The outcomes of interests included intraoperative outcomes (operative time, blood loss, length of incision, transfusion, and lymph nodes harvested), postoperative outcomes (length of hospital stay, length of postoperative hospital stay, time to first flatus, time to first liquid diet, time to first soft diet, time to first bowel movement, postoperative complications, reoperation, ileus, anastomotic leakage, wound infection, urinary complication, pulmonary infection, and mortality)...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816934/midterm-outcomes-of-intracranial-aneurysms-with-bleb-formation-with-densely-coiling-of-the-aneurismal-neck-or-entire-aneurysm
#6
Jun Wan, Lei Zhang, Gang Lu, Weijin Gu, Lei Huang, Liang Ge, Xiaolong Zhang, Lihua Ji, Qing Chen, Ruoyu Di, Yeqing Jiang
To evaluate whether the efficacy and safety of embolization of the aneurysmal neck were better than those of embolization of the entire aneurysm. Previous studies found that embolization of the aneurysmal neck can be used for treating ruptured intracranial aneurysm with bleb formation.In all, 163 patients with ruptured aneurysms with bleb formation who underwent endovascular embolization at the Shanghai Municipal Jing'an District Central Hospital from January 2014 to August 2015 were divided into the embolization of aneurysmal neck group (neck group; 87 cases) and embolization of entire aneurysm group (aneurysm group; 76 cases)...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816520/emergence-of-two-distinct-subpopulations-from-klebsiella-pneumoniae-grown-in-the-stimulated-microgravity-environment
#7
Haili Wang, Wenliang Li, Lixiao Gu, Xiaofang Gao, Bin Ni, Haiteng Deng, Ruifu Yang, Yanping Han
AIM: To isolate and characterize the two phenotypically distinct subpopulations from Klebsiella pneumoniae clonal cultures grown in the simulate microgravity environment. MATERIALS & METHODS: Here clonal culture of K. pneumoniae strain ATCC BAA-1705 was grown within a vertically rotating wall vessel bioreactor. Microscopic, colony staining, biofilm assays and quantitative proteomics were used to define the features of subpopulations. RESULTS: Two subpopulations were isolated based on colony appearance and bacterial morphology and indicated the different capability of biofilm formation and antibiotics resistance...
August 17, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28816458/pressure-induced-emission-enhancement-of-carbazole-the-restriction-of-intramolecular-vibration
#8
Yarong Gu, Kai Wang, Yu-Xiang Dai, Guanjun Xiao, Yuguo Ma, Yuancun Qiao, Bo Zou
Pressure-induced emission enhancement (PIEE), a novel phenomenon on the enhancement of the solid-state emission efficiency of fluorophores, has been arousing wide attention in recent years. However, researches on PIEE are still in the early stage. To further pursue more enhanced efficiency, discovering and designing more PIEE systems would be urgently desirable and of great importance. In this letter, we found carbazole presented a conspicuous emission enhancement under high pressure up to 1.0 GPa. In situ high-pressure infrared spectroscopy, angle-dispersive X-ray diffraction analysis combined with Hirshfeld surface theory calculation indicated that the PIEE of carbazole was attributed to the decrease of non-radiation vibration process...
August 17, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28816450/facile-synthesis-magnetic-and-electric-characterization-of-mixed-valence-la0-75k0-25amntio6-a-sr-and-ba-perovskites
#9
Ganghua Zhang, Haijie Chen, Zheming Gu, Peizhi Zhang, Tao Zeng, Fuqiang Huang
A new series of mixed valence perovskites, La0.75K0.25AMnTiO6 (A = Sr and Ba) nanocubes, have been synthesized by a mild hydrothermal route. From powder X-ray diffraction (XRD) analysis, the crystal structure of La0.75K0.25AMnTiO6 was solved as the orthorhombic symmetry (space group Pbnm) with a random A-site or B-site arrangement. The phase purity of the products was confirmed by ICP, SEM, and EDS analyses, and the oxidation states of the B-site metal atoms were determined to be +4 for Ti and +3/+4 for Mn from XPS results...
August 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28816174/-adverse-drug-reaction-reports-in-iceland-from-2013-to-2016-a-comparison-with-other-nordic-countries
#10
Sara Skulina Jonsdottir, Sigridur Maria Olafsdottir, Hrefna Gudmundsdottir
INTRODUCTION: Information regarding adverse drug reactions (ADRs) of new medications is based on clinical studies of selected populations. The reporting of ADRs from real-life use following the marketing of new active substances is instrumental for the continuous evaluation of their benefit-risk balance. The aim of this study was to determine the number and nature of ADR reports in Iceland and compare with other Nordic countries. MATERIALS AND METHODS: Reports of ADRs from 2013 to 2016 were examined using the Icelandic Medicines Agency´s database...
July 2017: Læknablađiđ
https://www.readbyqxmd.com/read/28816044/action-of-gold-nanospikes-based-nanoradiosensitizers-cellular-internalization-radiotherapy-and-autophagy
#11
Ningning Ma, Peidang Liu, Nongyue He, Ning Gu, Fu-Gen Wu, Zhan Chen
A major challenge to achieve effective X-ray radiation therapy is to use a relatively low and safe radiation dose. Various radiosensitizers, which can significantly enhance the radiotherapeutic performance, have been developed. Gold-based nanomaterials, as a new type of nanoparticle-based radiosensitizers, have been extensively used in researches involving cancer radiotherapy. However, the cancer therapeutic effect using the gold nanoparticle-based radiotherapy is usually not significant because of the low cellular uptake efficiency and the autophagy-inducing ability of these gold nanomaterials...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28815718/a-potential-high-risk-for-fatty-liver-disease-was-found-in-mice-generated-after-assisted-reproductive-techniques
#12
Gu Ll, Zhang Jj, Zheng Mm, Dong Gy, Xu Jy, Zhang Wy, Yibo Wu, Yang Yang, Zhu H
Abnormal gametogenesis and embryonic development may lead to poor health status of the offspring. The operations involved in the assisted reproductive technologies (ARTs) occur during the key stage of gametogenesis and early embryonic development. To assess the potential risk of abnormal lipid metabolism in the liver of adult ARTs offspring, two ARTs mice models derived from preimplantation genetic diagnosis (PGD group) and in vitro cultured embryos without biopsy (IVEM group) were constructed. And control mice were from in vivo naturally conceived (Normal group)...
August 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28815449/electrodeposition-of-sno2-on-fto-and-its-application-in-planar-heterojunction-perovskite-solar-cells-as-an-electron-transport-layer
#13
Yohan Ko, Yeong Rim Kim, Haneol Jang, Chanyong Lee, Man Gu Kang, Yongseok Jun
We report the performance of perovskite solar cells (PSCs) with an electron transport layer (ETL) consisting of a SnO2 thin film obtained by electrochemical deposition. The surface morphology and thickness of the electrodeposited SnO2 films were closely related to electrochemical process conditions, i.e., the applied voltage, bath temperature, and deposition time. We investigated the performance of PSCs based on the SnO2 films. Remarkably, the experimental factors that are closely associated with the photovoltaic performance were strongly affected by the SnO2 ETLs...
August 16, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28815374/the-roles-of-physical-activity-and-sedentary-behavior-on-hispanic-children-s-mental-health-a-motor-skill-perspective
#14
Xiangli Gu, M Jean Keller, Karen H Weiller-Abels, Tao Zhang
PURPOSE: Motor competence (MC) has been recognized as the foundation for life-time moderate-to-vigorous physical activity (MVPA) as well as an influential factor in reducing sedentary behavior during childhood. Guided by Blair et al.'s health model, the purpose of this study was to examine the behavioral mechanism of mental health including physical, psychosocial, and cognitive health among Hispanic children related to MC and MVPA. METHODS: A prospective research design was used with two-wave assessments across one academic year...
August 16, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28815255/-investigation-of-related-risk-factors-of-temporomandibular-disorders-in-109-patients
#15
Xin-Xin Hu, Yao-Min Zhu, Liu-Ting He, Ying Gu, Zhi-Gang Liang, Cang-Shang Zheng
PURPOSE: To investigate the related risk factors of temporomandibular disorders(TMD), and to provide evidences for clinical prevention. METHODS: One hundred and nine TMD patients were included in the study as case group, while 109 people with no TMJ symptoms and signs were selected randomly as control group. All subjects fulfilled questionaires. Logistics regression analysis was used to analyze the data with SPSS 22.0 software package. RESULTS: Females patients were more common than males, with 20~29 age group accounting for 44%...
April 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28814756/giant-pandas-can-discriminate-the-emotions-of-human-facial-pictures
#16
Youxu Li, Qiang Dai, Rong Hou, Zhihe Zhang, Peng Chen, Rui Xue, Feifei Feng, Chao Chen, Jiabin Liu, Xiaodong Gu, Zejun Zhang, Dunwu Qi
Previous studies have shown that giant pandas (Ailuropoda melanoleuca) can discriminate face-like shapes, but little is known about their cognitive ability with respect to the emotional expressions of humans. We tested whether adult giant pandas can discriminate expressions from pictures of half of a face and found that pandas can learn to discriminate between angry and happy expressions based on global information from the whole face. Young adult pandas (5-7 years old) learned to discriminate expressions more quickly than older individuals (8-16 years old), but no significant differences were found between females and males...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814165/ag-implantation-induces-mechanical-properties-cell-adhesion-and-antibacterial-effects-of-tin-ag-multilayers-in-vitro
#17
Xiuhua Sun, Huanhuan Gong, Dejun Li, Lei Dong, Mengli Zhao, Rongxin Wan, Hanqing Gu
AIM: This study aims to investigate the effect of Ag(+) implantation dose on the structure, hardness, adhesion strength, friction resistance, cell adhesion and antibacterial effects of TiN/Ag multilayers. METHODS: Nanoscale TiN/Ag multilayers were deposited on Ti-6Al-4V substrates using multiarc ion plating. The multilayers were then implanted by Ag ions. RESULTS: A distinct multilayer structure and large titanium nitride grains with better (111) crystallinity were proved...
August 17, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28814149/n-implantation-induce-cytocompatibility-of-shape-controlled-three-dimensional-self-assembly-graphene
#18
Ye Cao, Dejun Li, Mengli Zhao, Huanhuan Gong, Rongxin Wan, Hanqing Gu
AIM: The aim of the present research was to synthesize N(+) implanted 3D self-assembly graphene (N(+)/3D-SGHs) to overcome the weaknesses of graphene (small sizes and poor hydrophilicity) in tissue engineering scaffolds. MATERIALS & METHODS: N(+)/3D-SGHs was achieved by ion implantation on one-step hydrothermal synthesized 3D self-assembly graphene (3D-SGHs), and N(+)/3D-SGHs with different doses of nitrogen ions (1 × 10(16) ions/cm(2), 1 × 10(18) ions/cm(2) and 1 × 10(20) ions/cm(2)), which adjusted by nitrogen ion beam intensity...
August 17, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28813781/bee-venom-decreases-lps-induced-inflammatory-responses-in-bovine-mammary-epithelial-cells
#19
Chang Hee Jeong, Wei Nee Cheng, Hyojin Bae, Kyung Woo Lee, Sang Mi Han, Michael C Petriello, Hong Gu Lee, Han Geuk Seo, Sung Gu Han
The world dairy industry has long been challenged by bovine mastitis, an inflammatory disease, which causes economic loss due to decreased milk production and quality. Attempts have been made to prevent or treat this disease with multiple approaches, primarily through increased abuse of antibiotics, but effective natural solutions remain elusive. Bee venom (BV) contains a variety of peptides (e.g., melittin) and that shows multiple bioactivities including prevention of inflammation. Thus, in the current study, it was hypothesized that BV can reduce inflammation in bovine mammary epithelial cells (MAC-T)...
August 17, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28813691/effects-of-superabsorbent-polymers-on-the-abundances-of-antibiotic-resistance-genes-mobile-genetic-elements-and-the-bacterial-community-during-swine-manure-composting
#20
Aiyun Guo, Jie Gu, Xiaojuan Wang, Ranran Zhang, Yanan Yin, Wei Sun, Xiaxia Tuo, Li Zhang
Superabsorbent polymers (SAPs) are considered suitable amendments for reducing the selection pressure due to heavy metals and the abundances of antibiotic resistance genes (ARGs) during composting. In this study, three SAP (sodium polyacrylate) levels (0, 5, and 15mgkg(-1) of compost) were applied and their effects on the abundances of ARGs, mobile genetic elements (MGEs), and the bacterial community were investigated. After composting, the abundances of ARGs and MGEs decreased to different extent, where the removal efficiencies for tetW, dfrA7, ermX, aac(6')-ib-cr and MGEs exceeded 90%...
August 5, 2017: Bioresource Technology
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