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https://www.readbyqxmd.com/read/28098897/overexpression-of-arf1-is-associated-with-cell-proliferation-and-migration-through-pi3k-signal-pathway-in-ovarian-cancer
#1
Guifang Gu, Yannan Chen, Chengwei Duan, Linsen Zhou, Caiwen Chen, Jie Chen, Jialin Cheng, Nannan Shi, Yunfeng Jin, Qinghua Xi, Jianxin Zhong
ADP-ribosylation factor 1 (ARF1) is a small G protein that regulates many cellular processes such as reorganization of the actin cytoskeleton and is highly expressed in various tumor cells and tissues. However, the role of ARF1 in ovarian cancer progression remains unknown. In the present study, we explored the expression patterns of ARF1 in clinical ovarian cancer samples and adjacent noncancerous tissues. The results revealed that ARF1 overexpressed in EOC tissues and cell lines, compared with the adjacent non-tumorous tissues and normal ovarian cells...
January 18, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28098892/metabolomics-study-on-primary-dysmenorrhea-patients-during-the-luteal-regression-stage-based-on-ultra-performance-liquid-chromatography-coupled-with-quadrupole%C3%A2-time%C3%A2-of%C3%A2-flight-mass-spectrometry
#2
Ling Fang, Caiyun Gu, Xinyu Liu, Jiabin Xie, Zhiguo Hou, Meng Tian, Jia Yin, Aizhu Li, Yubo Li
Primary dysmenorrhea (PD) is a common gynecological disorder which, while not life‑threatening, severely affects the quality of life of women. Most patients with PD suffer ovarian hormone imbalances caused by uterine contraction, which results in dysmenorrhea. PD patients may also suffer from increases in estrogen levels caused by increased levels of prostaglandin synthesis and release during luteal regression and early menstruation. Although PD pathogenesis has been previously reported on, these studies only examined the menstrual period and neglected the importance of the luteal regression stage...
January 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28098749/a-semipersistent-plant-virus-differentially-manipulates-feeding-behaviors-of-different-sexes-and-biotypes-of-its-whitefly-vector
#3
Shaohua Lu, Jingjing Li, Xueli Wang, Danyang Song, Rune Bai, Yan Shi, Qinsheng Gu, Yen-Wen Kuo, Bryce W Falk, Fengming Yan
It is known that plant viruses can change the performance of their vectors. However, there have been no reports on whether or how a semipersistent plant virus manipulates the feeding behaviors of its whitefly vectors. Cucurbit chlorotic yellows virus (CCYV) (genus Crinivirus, family Closteroviridae) is an emergent plant virus in many Asian countries and is transmitted specifically by B and Q biotypes of tobacco whitefly, Bemisia tabaci (Gennadius), in a semipersistent manner. In the present study, we used electrical penetration graph (EPG) technique to investigate the effect of CCYV on the feeding behaviors of B...
January 13, 2017: Viruses
https://www.readbyqxmd.com/read/28098537/persistent-infections-with-diverse-co-circulating-astroviruses-in-pediatric-oncology-patients-memphis-tennessee-usa
#4
Valerie Cortez, Pamela Freiden, Zhengming Gu, Elisabeth Adderson, Randall Hayden, Stacey Schultz-Cherry
Human astroviruses are a major cause of pediatric gastroenteritis, especially in immunocompromised children. We conducted a retrospective study to demonstrate that diverse astrovirus genotypes can co-circulate in pediatric oncology patients. A subset of cases is associated with long-term virus shedding (range 17-183 days).
February 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28098403/mir-338-5p-promotes-inflammatory-response-of-fibroblast-like-synoviocytes-in-rheumatoid-arthritis-via-targeting-spry1
#5
Yan Yang, Yanfeng Wang, Qingwei Liang, Lutian Yao, Shizhong Gu, Xizhuang Bai
Our purpose is to study the roles of microRNA-338-5p (miR-338-5p) on the proliferation, invasion and inflammatory response of fibroblast-like synoviocytes (SFs) in rheumatoid arthritis patients by regulating SPRY1. The target relationship between miR-338-5p and SPRY1 was validated through luciferase reporter system. The expression of miR-338-5p and SPRY1 in synovial tissues and synovial cells were detected using RT-PCR and western blot. The mimics and inhibitors of miR-338-5p were transfected into SFs. MTT, Transwell and ELISA assays were used to analyze cell proliferation, invasiveness and the secreted extracellular pro-inflammatory cytokines (such as IL-1a, IL-6, COX2) levels of SFs...
January 18, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28098332/revisiting-the-optimized-doping-ratio-in-core-shell-nanostructured-upconversion-particles
#6
Bin Shen, Shengming Cheng, Yuyang Gu, Danrui Ni, Yilin Gao, Qianqian Su, Wei Feng, Fuyou Li
The development of rare-earth doped upconversion nanoparticles (RE-UCNPs) in various applications is fuelling the demand for nanoparticles with highly enhanced upconversion luminescence (UCL). Although the core/shell structure is proved to enhance the UCL effectively, there is still plenty of room to further improve the UCL by optimizing the doping ratio of the materials. In this article, a general strategy is demonstrated to achieve highly-enhanced visible UCL in core/shell nanostructured NaREF4 by increasing the doping ratio of Yb(3+) in the core region...
January 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28098274/janus-structured-pt-fenc-nanoparticles-as-a-catalyst-for-the-oxygen-reduction-reaction
#7
Kurian A Kuttiyiel, Kotaro Sasaki, Gu-Gon Park, Miomir B Vukmirovic, Lijun Wu, Yimei Zhu, Jingguang G Chen, Radoslav R Adzic
We present a new Janus structured catalyst consisting of Pt nanoparticles on Fe-N-C nanoparticles encapsulated by graphene layers for the ORR. The ORR activity of the catalyst increases under potential cycling as the unique Janus nanostructure is further bonded due to a synergetic effect. The present study describes an important advanced approach for the future design of efficient, stable, and low-cost Pt-based electrocatalytic systems.
January 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28097535/central-retinal-artery-occlusion-after-percutaneous-nephrolithotomy-lithotripsy-in-the-prone-position
#8
Shenye Gu, Nianci Shen, Dongya Wang, Jianping Lu, Lvjun Yang, Weidong Gu
No abstract text is available yet for this article.
January 17, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28096961/polysaccharide-from-sepia-esculenta-ink-and-cisplatin-inhibit-synergistically-proliferation-and-metastasis-of-triple-negative-breast-cancer-mda-mb-231-cells
#9
Hua-Zhong Liu, Wei Xiao, Yi-Peng Gu, Ye-Xing Tao, Da-Yan Zhang, Hui Du, Jiang-Hua Shang
OBJECTIVES: This paper aims to investigate synergistic inhibition of polysaccharide from Sepia esculenta ink (SIP), a newly isolated marine polysaccharide in our laboratory, on breast cancer MDA-MB-231 cells exposed to cisplatin. MATERIALS AND METHODS: Cell viability of MDA-MB-231 cells was determined by CCK 8 assay. Median-effect concentration was analyzed using Chou-Talalay method that was also subjected to determine cell inhibition ratio and combined index, as well as interaction between SIP and cisplatin...
December 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28096685/the-role-of-microrna-21-in-predicting-brain-metastases-from-non-small-cell-lung-cancer
#10
Jing Dong, Zhi Zhang, Tao Gu, Shu-Feng Xu, Li-Xin Dong, Xin Li, Bao-Hong Fu, Zhan-Zhao Fu
OBJECTIVE: This study aimed at exploring the role of microRNA-21 (miR-21) in predicting brain metastases (BM) from non-small cell lung cancer (NSCLC). METHODS: A total of 132 NSCLC patients, including 68 patients with BM and 64 patients without BM, were included in the study. NSCLC cells were collected and assigned to the inhibitor (IN) group, the mock group, and the negative control (NC) group. The quantitative real-time polymerase chain reaction assay was used to detect the miR-21 expression...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28096348/transcriptomic-proteomic-and-metabolomic-landscape-of-positional-memory-in-the-caudal-fin-of-zebrafish
#11
Jeremy S Rabinowitz, Aaron M Robitaille, Yuliang Wang, Catherine A Ray, Ryan Thummel, Haiwei Gu, Danijel Djukovic, Daniel Raftery, Jason D Berndt, Randall T Moon
Regeneration requires cells to regulate proliferation and patterning according to their spatial position. Positional memory is a property that enables regenerating cells to recall spatial information from the uninjured tissue. Positional memory is hypothesized to rely on gradients of molecules, few of which have been identified. Here, we quantified the global abundance of transcripts, proteins, and metabolites along the proximodistal axis of caudal fins of uninjured and regenerating adult zebrafish. Using this approach, we uncovered complex overlapping expression patterns for hundreds of molecules involved in diverse cellular functions, including development, bioelectric signaling, and amino acid and lipid metabolism...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28096330/spectroscopic-evidence-for-bulk-band-inversion-and-three-dimensional-massive-dirac-fermions-in-zrte5
#12
Zhi-Guo Chen, R Y Chen, R D Zhong, John Schneeloch, C Zhang, Y Huang, Fanming Qu, Rui Yu, Q Li, G D Gu, N L Wang
Three-dimensional topological insulators (3D TIs) represent states of quantum matters in which surface states are protected by time-reversal symmetry and an inversion occurs between bulk conduction and valence bands. However, the bulk-band inversion, which is intimately tied to the topologically nontrivial nature of 3D Tis, has rarely been investigated by experiments. Besides, 3D massive Dirac fermions with nearly linear band dispersions were seldom observed in TIs. Recently, a van der Waals crystal, ZrTe5, was theoretically predicted to be a TI...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28096206/racial-and-ethnic-differences-in-antihypertensive-medication-use-and-blood-pressure-control-among-us-adults-with-hypertension-the-national-health-and-nutrition-examination-survey-2003-to-2012
#13
Anna Gu, Yu Yue, Raj P Desai, Edgar Argulian
BACKGROUND: A key to reduce and eradicate racial disparities in hypertension outcomes is to understand their causes. We aimed at evaluating racial differences in antihypertensive drug utilization patterns and blood pressure control by insurance status, age, sex, and presence of comorbidities. METHODS AND RESULTS: A total of 8796 hypertensive individuals ≥18 years of age were identified from the National Health and Nutrition Examination Survey (2003-2012) in a repeated cross-sectional study...
January 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28096076/a-landscape-of-synthetic-viable-interactions-in-cancer
#14
Yunyan Gu, Ruiping Wang, Yue Han, Wenbin Zhou, Zhangxiang Zhao, Tingting Chen, Yuanyuan Zhang, Fuduan Peng, Haihai Liang, Lishuang Qi, Wenyuan Zhao, Da Yang, Zheng Guo
Synthetic viability, which is defined as the combination of gene alterations that can rescue the lethal effects of a single gene alteration, may represent a mechanism by which cancer cells resist targeted drugs. Approaches to detect synthetic viable (SV) interactions in cancer genome to investigate drug resistance are still scarce. Here, we present a computational method to detect synthetic viability-induced drug resistance (SVDR) by integrating the multidimensional data sets, including copy number alteration, whole-exome mutation, expression profile and clinical data...
January 17, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28095863/dietary-intake-of-n-3-pufas-modifies-the-absorption-distribution-and-bioavailability-of-fatty-acids-in-the-mouse-gastrointestinal-tract
#15
Qin Yang, Shunhe Wang, Yunqi Ji, Haiqin Chen, Hao Zhang, Wei Chen, Zhennan Gu, Yong Q Chen
BACKGROUND: Dietary polyunsaturated fatty acids (PUFAs), especially n-3 PUFAs, are important for human health. The intestinal tract, a location that is heavily colonized by microorganisms, is the main organ for absorbing fatty acids. METHODS: The purpose of this study was to analyze the effects of dietary n-3 and n-6 PUFAs on the distribution of different types of fatty acids and their bioavailability along the gut. Mice were fed for a week with experimental diets containing high n-3 or high n-6 fatty acid levels...
January 17, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28095697/diazo-esters-as-dienophiles-in-intramolecular-4-2-cycloadditions-computational-explorations-of-mechanism
#16
Abing Duan, Peiyuan Yu, Fang Liu, Huang Qiu, Feng Long Gu, Michael P Doyle, Kendall N Houk
The first experimental examples of Diels-Alder (DA) reactions of diazo compounds as heterodienophiles with dienes have been studied with density functional theory (DFT) using the M06-2X functional. For comparison, the reactivities of diazo esters as dienophiles or 1,3-dipoles with
1,3-dienes in intermolecular model systems have been analyzed by the distortion/interaction model. The 1,3-dipolar cycloaddition is strongly favored for the intermolecular system. The intramolecular example is unique because the tether strongly favors the (4+2) cycloaddition...
January 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28095654/prevalence-and-molecular-characterization-of-intestinal-trichomonads-in-pet-dogs-in-east-china
#17
Wen-Chao Li, Kai Wang, Wei Zhang, Jingjing Wu, You-Fang Gu, Xi-Chen Zhang
The trichomonad species Tritrichomonas foetus and Pentatrichomonas hominis were recently detected in the feces of dogs with diarrhea. However, little information is available on the prevalence and pathogenicity of these parasites in the canine population. Therefore, the aim of this study was to determine the prevalence and molecular characterization of trichomonads infecting pet dogs in Anhui and Zhejiang provinces, east China. In total, 315 pet dogs, with or without diarrhea, from 7 pet hospitals were included in this epidemiological survey...
December 2016: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28095407/a-novel-imprinted-gene-nuwa-controls-mitochondrial-function-in-early-seed-development-in-arabidopsis
#18
Shan He, Yan Sun, Qian Yang, Xiangyu Zhang, Qingpei Huang, Peng Zhao, Mengxiang Sun, Jingjing Liu, Weiqiang Qian, Genji Qin, Hongya Gu, Li-Jia Qu
Imprinted genes display biased expression of paternal and maternal alleles- and are only found in mammals and flowering plants. Compared to several hundred imprinted genes that are functionally characterized in mammals, very few imprinted genes were confirmed in plants and even fewer of them have been functionally investigated. Here, we report a new imprinted gene, NUWA, in plants. NUWA is an essential gene, because loss of its function resulted in reduced transmission through the female gametophyte and defective cell/nuclear proliferation in early Arabidopsis embryo and endosperm...
January 17, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28095120/the-bent-conformation-of-poly-a-binding-protein-induced-by-rna-binding-is-required-for-its-translational-activation-function
#19
Ka Young Hong, Seung Hwan Lee, Sohyun Gu, Eunah Kim, Sihyeon An, Junyoung Kwon, Jong-Bong Lee, Sung Key Jang
A recent study revealed that poly(A)-binding protein (PABP) bound to poly(A) RNA exhibits a sharply bent configuration at the linker region between RNA-recognition motif 2 (RRM2) and RRM3, whereas free PABP exhibits a highly flexible linear configuration. However, the physiological role of the bent structure of mRNA-bound PABP remains unknown. We investigated a role of the bent structure of PABP by constructing a PABP variant that fails to form the poly(A)-dependent bent structure but maintains its poly(A)-binding activity...
January 17, 2017: RNA Biology
https://www.readbyqxmd.com/read/28094887/exploring-the-influence-of-aggregation-on-the-structure-and-fluorescent-properties-of-a-tetraphenylethylene-derivative-a-theoretical-study
#20
Ying-Chen Duan, Yong Wu, Jun-Ling Jin, Dong-Mei Gu, Yun Geng, Min Zhang, Zhongmin Su
The case that aggregation brings a huge influence on the structure and fluorescent property of 5-(4-(1,2,2-triphenylvinyl)phenyl)thiophene-2-carbaldehyde (P4TA) was detailedly investigated here by employing both quantum mechanics and molecular mechanics. Besides the isolated molecule, the aggregated molecule both in water and crystal state was studied by focusing on the comparison of photoelectronic properties, including the geometrical and electronic structures at ground and excited states, emission and internal conversation properties...
January 17, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
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