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https://www.readbyqxmd.com/read/28723166/automated-3-d-printed-arrays-to-evaluate-genotoxic-chemistry-e-cigarettes-and-water-samples
#1
Karteek Kadimisetty, Spundana Malla, James F Rusling
A novel, automated, low cost, three-dimensional (3-D) printed microfluidic array was developed to detect DNA damage from metabolites of chemicals in environmental samples. The electrochemiluminescent (ECL) detection platform incorporates layer-by-layer (LbL) assembled films of microsomal enzymes, DNA and an ECL-emitting ruthenium metallopolymer in ∼10 nm deep microwells. Liquid samples are introduced into the array, metabolized by the human enzymes, products react with DNA if possible, and DNA damage is detected by ECL with a camera...
May 26, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28709087/novel-electrochemiluminescence-of-silver-nanoclusters-fabricated-on-triplex-dna-scaffolds-for-label-free-detection-of-biothiols
#2
Lingyan Feng, Li Wu, Feifei Xing, Lianzhe Hu, Jinsong Ren, Xiaogang Qu
Electrochemiluminescence (ECL) of metal nanoclusters and their application have been widely reported due to the good biocompatibility, fascinating electrocatalytic activity and so on. Using DNA as synthesis template opens new opportunities to modulate the physical properties of AgNCs. Triplex DNA has been reported for the site-specific, homogeneous and highly stable silver nanoclusters (AgNCs) fabrication from our recent research. Here we further explore their extraordinary ECL properties and applications in biosensor utilization...
July 6, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28702989/mos2-quantum-dots-as-new-electrochemiluminescence-emitters-for-ultrasensitive-bioanalysis-of-lipopolysaccharide
#3
Min Zhao, Anyi Chen, Dan Huang, Yaqin Chai, Ying Zhuo, Ruo Yuan
Cd-based semiconductor quantum dots (QDs) with size-tunable luminescence and high quantum yield have become the most promising electrochemiluminescence (ECL) emitters. However, their unavoidable biotoxicity limited their applications in bioassays. Here, the nontoxic and economical MoS2 QDs prepared by chemical exfoliation from the bulk MoS2 were first investigated as new ECL emitters, and then the possible luminescence mechanism of MoS2 QDs was studied using ECL-potential curves and differential pulse voltammetry (DPV) methods in detail...
July 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28702574/electrogenerated-chemiluminescence-logic-gate-operations-based-on-molecule-responsive-organic-microwires
#4
Jianmin Gu, Jingxiao Wu, Yahui Gao, Tianhui Wu, Qing Li, Aixue Li, Jian-Yao Zheng, Bin Wen, Faming Gao
Complex logic gate operations using organic microwires as signal transducers based on electrogenerated chemiluminescence (ECL) intensity as the optical readout signal have been developed by taking advantage of the unique ECL reaction between organic semiconductor 9,10-bis(phenylethynyl)anthracene (BPEA) microwires and small molecules. The BPEA microwires, prepared on cleaned-ITO substrate using a simple physical vapor transport (PVT) method, were subsequently used for construction of the ECL sensors. The developed sensor exhibits high ECL efficiency and excellent stability in the presence of co-reactant tripropylamine...
July 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28697444/an-efficient-electrochemiluminescence-amplification-strategy-via-bis-co-reaction-accelerator-for-sensitive-detection-of-laminin-to-monitor-overnutrition-associated-liver-damage
#5
Jing Zhao, Wen-Bin Liang, Yan-Mei Lei, Yang-Xue Ou, Ya-Qin Chai, Ruo Yuan, Ying Zhuo
With the world wildly improvement in dietary and nutrition status, it couldn't be ignored that the chronic liver disease (CLD) resulted from the overnutrition. In order to estimate nutrition status for healthy living, an efficient and sensitive electrochemiluminescence (ECL) sandwich immunosensor of laminin (LN), a marker of CLD, was proposed for early diagnosis of CLD. In this work, the anodic ECL behavior of perylene derivative using H2O2 as co-reactant was demonstrated and the possible ECL mechanism was proposed...
July 3, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28693359/coagulation-monitoring-correlation-with-heparin-dose-in-pediatric-extracorporeal-life-support
#6
Katie Moynihan, Kerry Johnson, Lahn Straney, Christian Stocker, Ben Anderson, Prem Venugopal, John Roy
OBJECTIVES: Extracorporeal Life Support (ECLS) risks thrombotic and hemorrhagic complications. Optimal anti-coagulation monitoring is controversial. We compared coagulation tests evaluating the heparin effect in pediatric ECLS. METHODS: A retrospective study of children (<18yrs) undergoing ECLS over 12 months in a tertiary pediatric intensive care unit (PICU). Variables included anti-Factor Xa activity (anti-Xa), activated partial thromboplastin time (aPTT), activated clotting time (ACT) and thromboelastogram (TEG(®)6s) parameters: ratio and delta reaction (R) times (the ratio and difference, respectively, between R times in kaolin assays with and without heparinase)...
July 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28689646/higher-m30-and-high-mobility-group-box-1-protein-levels-in-ex-vivo-lung-perfusate-are-associated-with-primary-graft-dysfunction-after-human-lung-transplantation
#7
Kohei Hashimoto, Marcelo Cypel, Stephen Juvet, Tomohito Saito, Ricardo Zamel, Tiago N Machuca, Michael Hsin, Hyunhee Kim, Thomas K Waddell, Mingyao Liu, Shaf Keshavjee
BACKGROUND: Ex vivo lung perfusion (EVLP) enables assessment of marginal donor lungs for transplantation, with similar clinical outcomes to conventional lung transplantation. We investigated whether cell death-related proteins in the EVLP perfusate could predict primary graft dysfunction (PGD) after transplantation. METHODS: M30 (indicating epithelial apoptosis), M65 (indicating total epithelial cell death), and high mobility group box 1 (HMGB-1, related to cell death and inflammation) protein levels in EVLP perfusate were measured by enzyme-linked immunosorbent assay and correlated with clinical outcomes...
June 21, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28682938/improving-patient-selection-for-refractory-out-of-hospital-cardiac-arrest-treated-with-extracorporeal-life-support
#8
Tahar Chouihed, Antoine Kimmoun, Adrien Lauvray, Francois-Xavier Laithier, Deborah Jaeger, Simon Lemoine, Juan Pablo Maureira, Lionel Nace, Kevin Duarte, Stéphane Albizzati, Nicolas Girerd, Bruno Levy
BACKGROUND: Despite recent management improvement, including Extra-Corporeal Life Support (ECLS), refractory out-of-hospital cardiac arrest (ROHCA) survival remains dramatically low. METHODS: We assessed an innovative strategy (Out of hoSpital Cardiac ARrest-ExtraCorporeal Life Support - "OSCAR-ECLS") to optimize access to ECLS of ROHCA patients and reduce the delay between recognition and ECLS implantation. METHODS: This study, conducted in a tertiary teaching hospital, compared the survival and delay times of ROHCA patients treated by ECLS before and after OSCAR-ECLS implementation...
July 4, 2017: Shock
https://www.readbyqxmd.com/read/28682359/improved-stability-of-transparent-pedot-pss-ag-nanowire-hybrid-electrodes-by-using-non-ionic-surfactants
#9
Sunghee Kim, Su Jeong Lee, Sunghwan Cho, Sangbaie Shin, Unyong Jeong, Jae-Min Myoung
A hybrid electrode, PEDOT:PSS/Ag NW containing a non-ionic surfactant (Triton X-100), was developed to enhance the mechanical stability of the Ag NW electrode and used for flexible ECL displays. The resulting hybrid electrode exhibited an outstanding figure of merit value of 12.3 × 10(-3) Ω(-1) and stable luminescence efficiency under the bending test.
July 6, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28681898/red-emitted-electrochemiluminescence-by-yellow-fluorescent-thioglycol-glutathione-dual-thiolate-co-coated-au-nanoclusters
#10
Hui Jiang, Liu Liu, Xuemei Wang
This study reports the occurrence of a special red-emitted anodic electrochemiluminescence (ECL) emission at +1.4 V (vs. Ag/AgCl) on a glass carbon electrode (GCE) after the addition of thioglycol (TG) to surface-unsaturated glutathione (GSH)-coated Au nanoclusters (NCs), with an emission peak at ∼630 nm. Compared to the ECL at a potential of +1.8 V (vs. Ag/AgCl) and an emission peak at 580 nm (corresponding to fluorescence) for only GSH-coated Au NCs, this ECL emission not only exhibits a lower ECL potential but also shows a significantly red-shifted emission wavelength up to ∼50 nm...
July 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28679602/severity-assessment-in-maximally-treated-ich-patients-the-max-ich-score
#11
Jochen A Sembill, Stefan T Gerner, Bastian Volbers, Tobias Bobinger, Hannes Lücking, Stephan P Kloska, Stefan Schwab, Hagen B Huttner, Joji B Kuramatsu
OBJECTIVE: As common prognostication models in intracerebral hemorrhage (ICH) are developed variably including patients with early (<24 hours) care limitations (ECL), we investigated its interaction with prognostication in maximally treated patients and sought to provide a new unbiased severity assessment tool. METHODS: This observational cohort study analyzed consecutive ICH patients (n = 583) from a prospective registry over 5 years. We characterized the influence of ECL on overall outcome by propensity score matching and on conventional prognostication using receiver operating characteristic analyses...
July 5, 2017: Neurology
https://www.readbyqxmd.com/read/28677968/enhanced-electrochemiluminescence-behavior-of-gold-silver-bimetallic-nanoclusters-and-its-sensing-application-for-mercury-ii
#12
Qingfeng Zhai, Huanhuan Xing, Xiaowei Zhang, Jing Li, Erkang Wang
Bimetallic nanoclusters (NCs) with superior performance to that of monometallic nanoclusters have attracted extensive research interest due to the synergetic effect of the two atoms. Inspired from the silver effect on the enhanced fluorescence intensity of Au NCs, a series of bovine serum albumin-protected Au-Ag bimetallic NCs were prepared by regulating the molar ratios of HAuCl4/AgNO3 and their electrochemiluminescence (ECL) property was investigated using triethylamine as co-reactant. Notably, multifold higher efficiency was achieved with Au-Ag bimetallic NCs in reference to the monometallic nanoclusters...
July 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28674892/surface-profiling-of-extracellular-vesicles-from-plasma-or-ascites-fluid-using-dotscan-antibody-microarrays
#13
Larissa Belov, Susannah Hallal, Kieran Matic, Jerry Zhou, Sandra Wissmueller, Nuzhat Ahmed, Sumaiya Tanjil, Stephen P Mulligan, O Giles Best, Richard J Simpson, Richard I Christopherson
DotScan antibody microarrays were initially developed for the extensive surface profiling of live leukemia and lymphoma cells. DotScan's diagnostic capability was validated with an extensive clinical trial using mononuclear cells from the blood or bone marrow of leukemia or lymphoma patients. DotScan has also been used for the profiling of surface proteins on peripheral blood mononuclear cells (PBMC) from patients with HIV, liver disease, and stable and progressive B-cell chronic lymphocytic leukemia (CLL)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28669500/one-year-experience-with-a-mobile-extracorporeal-life-support-service
#14
Jacob Gutsche, William Vernick, Todd A Miano
BACKGROUND: Severe acute respiratory distress syndrome is associated with a high mortality rate. The International Extracorporeal Membrane Oxygenation Network recommends regionalization of extracorporeal life support (ECLS) to high-volume centers and development of mobile ECLS teams to rescue patients with severe acute respiratory disease. METHODS: A tertiary medical center developed a mobile team and the infrastructure to support a ECLS transport service available 24 hours a day, 7 days a week...
June 29, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28669191/2d-electrochemiluminescence-light-emission-confined-at-the-oil-water-interface-in-emulsions-stabilized-by-luminophore-grafted-microgels
#15
Remy Bois, Sabina Scarabino, Valerie Ravaine, Neso Sojic
We describe a method to confine electrochemiluminescence (ECL) at the oil-water interface of emulsion droplets which are stabilized by luminophore-grafted microgels. These hydrogel nanoparticles incorporating covalently-bound 〖Ru(bpy)〗_3^(2+) as the luminophore are irreversibly adsorbed at the interface of micrometric oil droplets dispersed in a continuous aqueous phase. We study the electrochemical and ECL properties of this multiscale system, composed of a collection of droplets in close contact in the presence of two types of model coreactants...
July 2, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28668771/label-free-electrochemiluminescence-assay-for-aqueous-hg-2-through-oligonucleotide-mediated-assembly-of-gold-nanoparticles
#16
Dong-Mei Wang, Qi-Qi Gai, Rong-Fu Huang, Xingwang Zheng
Development of ultrasensitive method for Hg(2+) analysis is important for human health protection and environment monitoring. In this work, we present a highly sensitive and selective electrochemiluminescence (ECL) assay in a "turn-on" mode for the detection of Hg(2+) through selective assembly of gold nanoparticles (AuNPs) on the surface of indium tin oxide (ITO) electrode. In the absence of Hg(2+), the nonthiolated ssDNA could protected AuNPs against its assembly on ITO surface, producing rather low ECL emission for Ru(bpy)3(2+)/TPA system...
June 28, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28660761/bipolar-electrode-based-multi-color-electrochemiluminescence-biosensor
#17
Yinzhu Wang, Cong-Hui Xu, Wei Zhao, Qi-Yuan Guan, Hong-Yuan Chen, Jing-Juan Xu
We report a multi-color ECL device based on closed bipolar electrode (BPE) for the visualized sensing of prostate-specific antigen (PSA) in human blood serum. As the emission color of concomitant electrochemiluminophores is potential resolved, similar to a three-electrode system, selective excitation of ECL could be achieved by tuning the interfacial potential at the poles of BPE. Via modulating the resistance of BPE, multi-color ECL emission of [Ru(bpy)3]2+ and [Ir(ppy)3] mixture using tripropylamine (TPrA) as the co-reactant was observed at the anode and the principle was elaborated...
June 29, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28650027/cationic-2-2-bipyridine-complexes-of-germanium-ii-and-tin-ii
#18
Paul A Gray, Katherine D Krause, Neil Burford, Brian O Patrick
We present the first systematic study of 2,2'-bipyridine complexes of E(ii) cationic acceptors (E = Ge, Sn). The complexes were comprehensively characterized by spectroscopic and crystallographic methods to yield complexes of ECl(1+) and E(2+). Computational DFT methods were also employed to survey the bonding in the cations, along with an examination of their molecular orbitals (MOs).
June 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28649026/proximity-hybridization-regulated-electrogenerated-chemiluminescence-bioassay-of-%C3%AE-fetoprotein-via-target-induced-quenching-mechanism
#19
Hongfang Gao, Xiaofei Wang, Man Li, Honglan Qi, Qiang Gao, Chengxiao Zhang
A proximity hybridization-regulated electrogenerated chemiluminescence (PLA-ECL) bioassay was developed for the detection of α-fetoprotein (AFP) on basis of the sensitization of gold nanoparticles (AuNPs) and target-induced quenching mechanism. Ru(bpy)3(2+) was used as ECL signal while ferrocene (Fc) was used as ECL quencher. Ru(bpy)3(2+) was electrostatically adsorbed into the AuNPs/Nafion film prepared by casting the mixture of Nafion and AuNPs onto the surface of glassy carbon electrode (GCE) to form an ECL platform (Ru(bpy)3(2+)/AuNPs/Nafion/GCE), which displayed strong ECL emissions...
June 21, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28644005/from-electrochemistry-to-electroluminescence-development-and-application-in-a-ratiometric-aptasensor-for-aflatoxin-b1
#20
Long Wu, Fan Ding, Wenmin Yin, Jing Ma, Biru Wang, Axiu Nie, Heyou Han
Aflatoxin B1 (AFB1), one of the most toxic chemical carcinogens, has been widely studied. It remains challenging to develop simple, accurate, and sensitive analytical methods for the detection of AFB1 in food matrixes. In this work, on the basis of a dual-signaling strategy, a ratiometric aptasensor was designed and verified for the accurate and sensitive detection of AFB1. The electrochemical method was first used as a model to verify the specific interaction between AFB1 and the aptamer, in which ferrocene (Fc)-anchored and methylene blue (MB)-anchored DNA sequences acted as dual signals...
July 7, 2017: Analytical Chemistry
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