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Liwei Zhang, Wen-Jui Han
Using Early Childhood Longitudinal Study, Kindergarten Class of 1998-1999 (ECLS-K), we investigated the relationship between poverty and academic trajectories for children in immigrant families in the United States. We used family socioeconomic status (SES) which considers parental education, parental occupation, and family income to define poverty in correspondence with the U.S. federal poverty threshold. Three dimensions of poverty were examined including depth (i.e., not-poor, near-poor, poor or extreme poor), stability (i...
September 16, 2017: International Journal of Environmental Research and Public Health
Lei Yang, Yueyuan Li, Yong Zhang, Dawei Fan, Xuehui Pang, Qin Wei, Bin Du
We developed a novel Ru(bpy)32+-based electrochemiluminescence (ECL) immunosensor utilizing palladium nanoparticles (Pd NPs) functionalized graphene aerogel supported Fe3O4 (FGA-Pd) for real sample analysis of prostate specific antigen (PSA). 3D nanostructured FGA-Pd, as a novel ECL carrier, was prepared by in situ reduction. Large amounts of Ru(bpy)32+ could combine with FGA-Pd via electrostatic interaction to establish a brand-new ECL emitter (Ru@FGA-Pd) for improving ECL efficiency. The obtained Ru@FGA-Pd composite was utilized to label the secondary antibody, which generated strong ECL signals with tripropylamine (TPrA) as coreactant...
September 19, 2017: ACS Applied Materials & Interfaces
Serena Carrara, Alessandro Aliprandi, Conor F Hogan, Luisa De Cola
We report the electrochemiluminescence properties of square-planar Pt(II) complexes which result from the formation of supramolecular nanostructures. We define this new phenomenon as Aggregation-Induced Electrochemiluminescence (AIECL). In this system, self-assembly changes the HOMO and LUMO energies, making their population accessible via ECL pathways and leading to the generation of the luminescent excited state. Significantly, the emission from the self-assembled system is the first example of Electro-chemiluminescence (ECL) of Pt(II) complexes in aque-ous solution having higher efficiency than the standard, Ru(bpy)32+...
September 15, 2017: Journal of the American Chemical Society
Alba Iglesias, Marta Cimadevila, Rocío Ailim de la Fuente, María Martí-Solano, María Isabel Cadavid, Marián Castro, Jana Selent, María Isabel Loza, José Brea
The serotonin 2A (5-HT2A) receptor is a G-protein coupled receptor (GPCR) with a conserved disulfide bridge formed by Cys(148) (transmembrane helix 3, TM3) and Cys(227) (extracellular loop 2, ECL-2). We hypothesized that disulfide bridges may determine serotonin 5-HT2A receptor functions such as receptor activation, functional selectivity and ligand recognition. We used the reducing agent dithiothreitol (DTT) to determine how the reduction of disulfide bridges affects radioligand binding, second messenger mobilization and receptor dimerization...
September 9, 2017: European Journal of Pharmacology
Lijuan Zheng, Chen Fang, Jilin Yan, Huiling Li, Yifeng Tu
In this paper, a new strategy is reported for preparing a label-free β-trophin electrochemiluminescent (ECL) immunosensor with good specificity, reproducibility and stability. An aquagel polymer from the hydrolysis of (3-aminopropyl) trimethoxysilane acted as the linker to catch the Au nanoparticles (AuNPs) on the indium-tin oxide (ITO) substrate by a two-step method. The AuNPs play an important role in enhancing ECL and immobilizing the β-trophin antibody. This immunosensor can test for β-trophin using luminol as an ECL probe...
September 11, 2017: Scientific Reports
Chee Kiang Tay, Kiick Sung, Yang Hyun Cho
Extracorporeal life support (ECLS) has been widely utilized to treat neonatal respiratory failure for two decades. However, its uptake in the case of adult respiratory failure has been slow because of a paucity of quality evidence and a sluggish tempo of ECLS-related technological advances. In recent years, interest in ECLS has been piqued after encouraging results were reported from its use during the 2009 H1N1 influenza pandemic. In a world constantly under threat from another influenza epidemic or deadly novel respiratory infection, e...
September 6, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Xiao-Lei Huo, Hui Yang, Wei Zhao, Jing-Juan Xu, Hong-Yuan Chen
In this study, we proposed a nanopore-based electrochemiluminescence (ECL) sensor combined with duplex-specific nuclease (DSN)-assisted target recycling amplification to detect microRNAs. Because of the synergetic effect of electrostatic repulsion and volume exclusion of gold nanoparticle-labeled DNA capture (DNA-Au NPs) to the negatively charged luminol anion probe, the DNA-Au NP-modified anodized aluminum oxide (AAO) nanopore electrode exhibited high ECL decline in comparison with the bare AAO electrode. Upon the introduction of DSN and target microRNA, the specific DNA-RNA binding and enzyme cleaving could trigger the detachment of capture DNA from the membrane surface, resulting in uncapping of AAO and an increased ECL signal...
September 14, 2017: ACS Applied Materials & Interfaces
Omar Ellouze, Melitine Vuillet, Justine Perrot, Sandrine Grosjean, Anis Missaoui, Serge Aho, Ghislain Malapert, Belaid Bouhemad, Oliver Bouchot, Claude Girard
Extracorporeal life support (ECLS) has shown benefits in the management of refractory in-hospital cardiac arrest (IHCA) by improving survival. Nonetheless, the results concerning out-of-hospital refractory cardiac arrests (OHCA) remain uncertain. The aim of our investigation was to compare survival between the two groups. We realized a single-center retrospective, observational study of all patients who presented IHCA or OHCA treated with ECLS between 2011 and 2015. Multivariate analysis was realized to determine independent factors associated with mortality...
September 6, 2017: Artificial Organs
Carlo P Ramil, Maoqing Dong, Peng An, Tracey M Lewandowski, Zhipeng Yu, Laurence J Miller, Qing Lin
A new bioorthogonal reactant pair, spiro[2.3]hex-1-ene (Sph) and 3,6-di(2-pyridyl)-s-tetrazine (DpTz), for the strain-promoted inverse electron-demand Diels-Alder cycloaddition, that is, tetrazine ligation, is reported. As compared to the previously reported strained alkenes such as trans-cyclooctene (TCO) and 1,3-disubstituted cyclopropene, Sph exhibits balanced reactivity and stability in tetrazine ligation with the protein substrates. A lysine derivative of Sph, SphK, was site-selectively incorporated into the extracellular loop regions (ECLs) of GCGR and GLP-1R, two members of class B G protein-coupled receptors (GPCRs) in mammalian cells with the incorporation efficiency dependent on the location...
September 15, 2017: Journal of the American Chemical Society
Yong Yao, Huijie Li, Dan Wang, Cuiling Liu, Chunsun Zhang
Cloth fabrics and smartphones have become the two things people are most familiar with. Particularly, smartphones are used as portable personal computers, revolutionizing communication and lifestyle. Here, screen-printing technology is applied to fabricate carbon electrodes and electrochemical chambers on a single hydrophilic cloth, while the cloth-based electrochemiluminescence (ECL) signals are read out by using an inexpensive smartphone. Therefore, the ECL detection is available in both low-cost disposable sensors and a portable format, which may be very suitable to be used as a non-invasive monitoring tool for medical diagnostics...
September 5, 2017: Analyst
Elizabeth Lawrence, Stefanie Mollborn
Enrollment into unequal schools at the start of formal education is an important mechanism for the reproduction of racial/ethnic educational inequalities. We examine whether there are racial/ethnic differences in school enrollment options at kindergarten, the start of schooling. We use nationally representative data from the Early Childhood Longitudinal Study-Birth Cohort (ECLS-B) to model whether parents seek information about their child's school before enrolling, whether parents move to a location so that a child can attend a certain school, or whether parents enroll their child in a school other than the assigned public school...
September 2017: Sociological Forum
Hug Aubin, George Petrov, Hannan Dalyanoglu, Maximillian Richter, Diyar Saeed, Payam Akhyari, Detlef Kindgen-Milles, Alexander Albert, Artur Lichtenberg
AIM: Mobile extracorporeal life support (ECLS) may soon be on the verge to become a fundamental part of emergency medicine. Here, we report on our four-year experience of providing advanced mechanical circulatory support for out-of-center patients within the Düsseldorf ECLS Network (DELSN). METHODS: This retrospective cohort study analyses the outcome of 160 patients with refractory circulatory failure consecutively treated with mobile veno-arterial extracorporeal membrane oxygenation (vaECMO) between July 2011 and October 2015 within the DELSN...
September 11, 2017: Resuscitation
Yuzhen Huang, Li Li, Yan Zhang, Lina Zhang, Shenguang Ge, Hao Li, Jinghua Yu
In this report, a 3D microfluidic lab-on-paper device for ultrasensitive detection of lead cation was designed using phoenix tree fruit-shaped CeO2 nanoparticles (PFCeO2 NPs) as the catalyst and 50 nm silver NPs (Ag NPs) as the quencher. First, snowflake-like Ag NPs were grown on the paper working electrode through an in situ growth method and used as a matrix for DNAzymes that were specific for lead ions (Pb(2+)). After the addition of Ag NP-labeled substrate strands, the Ag NPs restrained the electrochemiluminescence (ECL) intensity of luminol greatly through the resonance energy transfer from luminol to Ag NPs...
September 15, 2017: ACS Applied Materials & Interfaces
Ryota Sato, Akira Kuriyama, Michitaka Nasu, Shinnji Gima, Wataru Iwanaga, Tadaaki Takada, Yusuke Kitahara, Hideto Fukui, Terutake Yonemori, Masaharu Yagi
INTRODUCTION: Extracorporeal life support (ECLS) has been reported to be more effective than conventional cardiopulmonary resuscitation (CPR). In ECLS, a shorter time from arrival to implantation of extracorporeal membrane oxygenation (ECMO; door-to-ECMO) time was predicted to be associated with better survival rates. This study aimed to examine the impact of the physician-based emergency medical services (P-EMS) using a rapid response car (RRC) on door-to-ECMO time in patients with out-of-hospital cardiac arrest (OHCA)...
August 29, 2017: American Journal of Emergency Medicine
Wenjing Jiang, Linni Wu, Junling Duan, Huanshun Yin, Shiyun Ai
An ultrasensitive sandwiched electrochemiluminescence (ECL) immunosensor was developed for 5-hydroxymethylcytosine (5hmC) detection in genomic DNA by using Fe3O4@SiO2 core-shell magnetic nanomaterial as a immobilization matrix for anti-5hmC antibody, PAMAM conjugated avidin and Ru(bpy)2(phen-5-NH2)(PF6)2 as signal amplification unit. Importantly, Fe3O4@SiO2 nanoparticles were verified to not only possess enormous surface for loading antibody by amido link, but also exhibit excellent bioactivity. With the dual signal amplification strategy, the ECL immunosensor showed wide detection range from 0...
August 12, 2017: Biosensors & Bioelectronics
Haijun Wang, Yaqin Chai, Hang Li, Ruo Yuan
Electrochemiluminescence (ECL) co-reaction and ECL resonance energy transfer (ECL-RET) are two main methods for enhancing the ECL efficiency. In this work, a novel tris(bipyridine) ruthenium(II) derivative (Ru(bpy)2(mcbpy)(2+)-PEI-ABEI) with high ECL efficiency due to the binary intramolecular ECL self-catalyzed property including intramolecular co-reaction and intramolecular ECL-RET, was prepared for the construction of immunosensor. Firstly, through intramolecular co-reaction, polyethyleneimine (PEI) with large amount of amine co-reactive groups (primary, secondary and tertiary amine) not only increased the ECL intensity of Ru(bpy)2(mcbpy)(2+), but also improved the ECL signal of N-(aminobutyl)-N-(ethylisoluminol) (ABEI)...
August 26, 2017: Biosensors & Bioelectronics
Konrad Hoetzenecker, Walter Klepetko, Shaf Keshavjee, Marcelo Cypel
Extracorporeal life support (ECLS) is increasingly used for major airway surgery. It facilitates complex reconstructions and maintains gas exchange during endoscopic procedures in patients with critical airway obstruction. ECLS offers the advantage of an uncluttered surgical field and eliminates the need for crossing ventilation tubes, thus, making precise surgical dissection easier. ECLS is currently used for hemodynamic and respiratory support in lung transplantation as well as extended tumor resections with an acceptable risk profile...
July 2017: Journal of Thoracic Disease
Matteo Pozzi, Catherine Koffel, Camelia Djaref, Daniel Grinberg, Jean Luc Fellahi, Elisabeth Hugon-Vallet, Cyril Prieur, Jacques Robin, Jean François Obadia
BACKGROUND: Cardiac failure is still a leading cause of death in drug intoxication. Extracorporeal life support (ECLS) could be used as a rescue therapeutic option in patients developing refractory cardiogenic shock or cardiac arrest. The aim of this report is to present our results of ECLS in the setting of poisoning from cardiotoxic drugs. METHODS: We included in this analysis consecutive patients who received an ECLS for refractory cardiogenic shock or in-hospital cardiac arrest due to drug intoxication...
July 2017: Journal of Thoracic Disease
Jie Zhou, Yuan-Yuan Sun, Meng-Yao Sun, Wei-An Mao, Li Wang, Jian Zhang, Hong Zhang
BACKGROUND: Radix Saposhnikoviae (RS) exerts anti-inflammatory, analgesic, antipyretic, antioxidation effects and has been used in traditional Chinese medicine to treat common colds, headache, and rheumatoid arthritis. Prim-O-glucosylcimifugin (POG) is the highest content chromone and one of the major active constituents in RS. OBJECTIVE: The study was aimed to explore the anti-inflammation effects of POG in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages...
July 2017: Pharmacognosy Magazine
Xiao-Qiang Li, Rong Kang, Jun-Cheng Huo, Yan-Hua Xie, Si-Wang Wang, Wei Cao
BACKGROUND: The seed oil of Zanthoxylum bungeanum Maxim (ZBSO) is considered to be rich source of fatty acids, mainly oleic and linoleic acids, and has been used for the treatment of burns in Chinese medicine. OBJECTIVE: We evaluated the healing efficacy of ZBSO and explored its possible mechanism on scalded rats. MATERIALS AND METHODS: Sprague-Dawley rat models with deep second-degree burns were set up, and ZBSO (500 and 1000 μl/wound) was topically applied twice daily for 7 days and then once daily until wound healing...
July 2017: Pharmacognosy Magazine
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