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https://www.readbyqxmd.com/read/28926969/cardiovascular-activity-of-the-chemical-constituents-of-essential-oils
#1
REVIEW
Tadeu Uggere de Andrade, Girlandia Alexandre Brasil, Denise Coutinho Endringer, Flávio Rogério da Nóbrega, Damião Pergentino de Sousa
Cardiovascular diseases are a leading cause of death in developed and developing countries and decrease the quality of life, which has enormous social and economic consequences for the population. Recent studies on essential oils have attracted attention and encouraged continued research of this group of natural products because of their effects on the cardiovascular system. The pharmacological data indicate a therapeutic potential for essential oils for use in the treatment of cardiovascular diseases. Therefore, this review reports the current studies of essential oils chemical constituents with cardiovascular activity, including a description of their mechanisms of action...
September 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28926808/active-pharmaceutical-ingredients-entering-the-aquatic-environment-from-wastewater-treatment-works-a-cause-for-concern
#2
Sean Comber, Mike Gardner, Pernilla Sörme, Dean Leverett, Brian Ellor
This work reports on the variation in wastewater treatment works (WwTW) influent concentrations of a wide variety of active pharmaceutical ingredients (APIs), their removal efficiency, effluent concentrations and potential risks to the aquatic environment. The research is based on data generated from two large UK-wide WwTW monitoring programmes. Taking account of removal of parent compound from the aqueous phase during treatment in combination with estimates of dilution available it is possible to prioritise the APIs of greatest risk of exceeding estimates of predicted no effect concentrations (PNEC) in receiving waters for all WwTW in the UK...
September 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28926737/people-planet-and-profit-unintended-consequences-of-legacy-building-materials
#3
REVIEW
Anthony T Zimmer, HakSoo Ha
Although an explosion of new building materials are being introduced into today's market, adequate up-front research into their chemical and physical properties as well as their potential health and environmental consequences is lacking. History has provided us with several examples where building materials were broadly deployed into society only to find that health and environmental problems resulted in unintended sustainability consequences. In the following paper, we use lead and asbestos as legacy building materials to show their similar historical trends and sustainability consequences...
September 16, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28926343/the-impact-of-stress-on-social-behavior-in-adult-zebrafish-danio-rerio
#4
Shannon M Saszik, Conor M Smith
Stress has adverse effects on social behavior that is mediated by dopamine circuits in the midbrain. The purpose of this research is to examine the effect of chronic stress and dopamine signals on social behavior in zebrafish (Danio rerio). Chronic stress was induced chemically with low dosage of ethanol (0.25% for 5 days), and psychosocially with isolation (3-5 days) or overcrowding (5 days). Dopamine activity was decreased by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposure. Social behavior was observed by introducing one treated zebrafish to a group of four control zebrafish and measuring the nearest neighbor distance (NND)...
September 18, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28926224/silver-nanocluster-embedded-zein-films-as-antimicrobial-coating-materials-for-food-packaging
#5
Lei Mei, Zi Teng, Guizhi Zhu, Yijing Liu, Fuwu Zhang, Jinglin Zhang, Ying Li, Yongguang Guan, Yaguang Luo, Xianggui Chen, Qin Wang
Highly efficient antimicrobial agents with low toxicity and resistance have been enthusiastically pursued to address public concerns on microbial contamination in food. Silver nanoclusters (AgNCs) are known for their ultra-small sizes and unique optical and chemical properties. Despite extensive studies of AgNCs for biomedical applications, previous research on their application as antimicrobials for food applications is very limited. Here, for the first time, by incorporating AgNCs (~ 2 nm in diameter) into zein films that are widely used as food packaging materials, we developed a novel coating material with potent antimicrobial activity, low toxicity to human cells, and low potential to harm the environment...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28926137/metabolic-profile-of-rhizoma-coptidis-in-human-plasma-determined-using-ultra-high-performance-liquid-chromatography-coupled-with-high-resolution-mass-spectrometry
#6
Qing-Shan Zhang, Gao-Wa Wang, Zhi-Qiang Han, Xiang-Mei Chen, Risu Na, Haburi Jin, Ping Li, Renbatu Bu
RATIONALE: Rhizoma coptidis extract and its alkaloids show various pharmacological activities, but its metabolic profile in human plasma has not been thoroughly investigated. In the present research, the metabolism of Rhizoma coptidis at a clinical dose (5 g/60 kg/day) was systematically analyzed to determine its biotransformation processes in human plasma. METHODS: In this research, the metabolites of Rhizoma coptidis in human plasma after oral administration of Rhizoma coptidis extract at a clinical dose were investigated using ultra high-performance liquid chromatography (UHPLC) coupled with high-resolution LTQ-Orbitrap mass spectrometry...
September 19, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28926133/synthesis-of-thiophene-based-optical-ligands-that-selectively-detect-tau-pathology-in-alzheimer%C3%A2-s-disease
#7
Peter Nilsson, Hamid Shirani, Hanna Appelqvist, Marcus Bäck, Therese Klingstedt, Nigel Cairns
The accumulation of protein aggregates is associated with many devastating neurodegenerative diseases and the development of molecular ligands able to detect these pathological hallmarks is essential. Here, we report the synthesis of thiophene based optical ligands, denoted bi-thiophene-vinyl-benzothiazoles (bTVBTs) that can be utilized for selective assignment of tau aggregates in brain tissue with Alzheimer´s disease (AD) pathology. The ability of the ligands to selectively distinguish tau deposits from the other AD associated pathological hallmark, senile plaques consisting of aggregated amyloid-β (Aβ) peptide, were reduced when the chemical composition of the ligands were altered, verifying that specific molecular interactions between the ligands and the aggregates are necessary for the selective detection of tau deposits...
September 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28926123/isotopic-and-chemical-characteristics-of-mercury-in-organs-and-tissues-of-fish-in-a-mercury-polluted-lake-evidence-for-fractionation-of-mercury-isotopes-by-physiological-processes
#8
Togwell A Jackson
Organs and tissues of whitefish and trout from mercury (Hg)-polluted Lake Ontario were analysed for Hg isotopes, methylmercury (CH3 Hg(+) ), and inorganic Hg to investigate possible mass-dependent fractionation (MDF) and mass-independent fractionation (MIF) of Hg isotopes by physiological processes of the fish. Isotope signatures of different body parts were defined by δ-values of (198) Hg/(202) Hg, (199) Hg/(202) Hg, (200) Hg/(202) Hg, and (201) Hg/(202) Hg ratios and by Δ-values representing effects of MIF on (199) Hg/(202) Hg and (201) Hg/(202) Hg ratios...
September 19, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28926014/assessing-the-economic-impact-of-an-endemic-disease-the-case-of-mastitis
#9
H Hogeveen, M Van Der Voort
A large part of the world's resources are used to produce animal products. Efficient use of these resources is important to improve social well-being. Endemic animal diseases decrease production efficiency, because they require a higher level of input to produce the same amount of output or result in a lower output with the same amount of input. The optimal level of production with and without disease differs from farm to farm and depends on varying economic circumstances. Given these difficulties, making an accurate theoretical estimation of the economic impact of endemic diseases is challenging...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28925867/lignocellulosic-biomass-derived-functional-materials-synthesis-and-applications-in-biomedical-engineering
#10
Lei Zhang, Xinwen Peng, Linxin Zhong, Weitian Chua, Zhihua Xiang, Runcang Sun
The pertinent issue of resources shortage arising from global climate change in the recent years has accentuated the importance of materials that are environmental friendly. Despite the merits of current material like cellulose as the most abundant natural polysaccharide on earth, the incorporation of lignocellulosic biomass has the potential to value-add the recent development of cellulose-derivatives in drug delivery systems. Lignocellulosic biomass, with a hierarchical structure, comprised of cellulose, hemicellulose and lignin...
September 18, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28925706/field-effect-transistors-based-on-van-der-waals-grown-and-dry-transferred-all-inorganic-perovskites-ultrathin-platelets
#11
Chengxue Huo, Xuhai Liu, Xiufeng Song, Ziming Wang, Haibo Zeng
Nowdays, the research on perovskite transistors is still in its infancy, despite that perovskite based solar cells and light emitting diodes have been widely investigated. Two major hurdles exist before obtaining reliable perovskite based transistors: the processing difficulty for their sensitivity to polar solvents, and unsatisfactory perovskite quality on the transistor platform. Here, for the first time, we report on high-performance all-inorganic perovskite FETs profited from both van-der-Waals epitaxial boundary-free ultrathin single-crystals and completely dry-processed transfer technique without chemical contaminant...
September 19, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28925679/substance-p-mediated-dgls-complexing-with-dachpt-for-targeting-therapy-of-glioma
#12
Tao Sun, Xutao Jiang, Qingbing Wang, Qinjun Chen, Yifei Lu, Lisha Liu, Yu Zhang, Xi He, Chunhui Ruan, Yujie Zhang, Qin Guo, Yaohua Liu, Chen Jiang
Currently, glioblastoma (glioma) is described as the deadliest brain tumor for its invasive natural with exceeding difficulty in surgical excision. Blood-brain barrier (BBB) can restrict the penetration of most therapeutic reagents including platinum (Pt)-based drugs-the most widely used reagents in clinical trials for their revolutionized cancer chemotherapy against a broad range of tumors. Nanomedicine represents a promising strategy for the intravenous delivery of Pt-based drugs into the brain. In this research, with the aim of malignant glioma treatment by Pt-based drugs, a novel nano drug carrier was developed: dendrigraft poly-L-lysines (DGLs) was PEGylated, linked with diethylenetriaminpentaacetic acid (DTPA) to complex (1,2-diaminocyclohexane)platinum(II) (DACHPt), and modified with Substance P (SP) as a BBB/glioma dual-targeting moiety...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28925566/raman-spectroscopy-for-accurately-characterising-biomolecular-changes-in-androgen-independent-prostate-cancer-cells
#13
Stella Corsetti, Thomas Rabl, David McGloin, Ghulam Nabi
Metastatic prostate cancer resistant to hormonal manipulation is considered the advanced stage of the disease and leads to most cancer related mortality. With new research focusing on modulating cancer growth, it is essential to understand the biochemical changes in cells that can then be exploited for drug discovery and for improving responsiveness to treatment. Raman spectroscopy has a high chemical specificity and can be used to detect and quantify molecular changes at the cellular level. Collection of large datasets generated from biological samples can be employed to form discriminatory algorithms for detection of subtle and early changes in cancer cells...
September 19, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28925537/continental-extent-patterns-in-amphibian-malformations-linked-to-parasites-chemical-contaminants-and-their-interactions
#14
Sarah E Haas, Mari K Reeves, Alfred E Pinkney, Pieter T J Johnson
Widespread observations of malformed amphibians across North America have generated both concern and controversy. Debates over the causes of such malformations-which can affect >50% of animals in a population-have continued, likely due to involvement of multiple causal factors. Here, we used a 13-year dataset encompassing 53,880 frogs and toads from 422 wetlands and 42 states in the conterminous USA to test hypotheses relating abnormalities and four categories of potential drivers: (1) chemical contaminants, (2) land use practices, (3) parasite infection, and (4) targeted interactions between parasites and pesticides...
September 19, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28925386/5-hydroxymethylcytosine-signatures-in-circulating-cell-free-dna-as-diagnostic-biomarkers-for-human-cancers
#15
Wenshuai Li, Xu Zhang, Xingyu Lu, Lei You, Yanqun Song, Zhongguang Luo, Jun Zhang, Ji Nie, Wanwei Zheng, Diannan Xu, Yaping Wang, Yuanqiang Dong, Shulin Yu, Jun Hong, Jianping Shi, Hankun Hao, Fen Luo, Luchun Hua, Peng Wang, Xiaoping Qian, Fang Yuan, Lianhuan Wei, Ming Cui, Taiping Zhang, Quan Liao, Menghua Dai, Ziwen Liu, Ge Chen, Katherine Meckel, Sarbani Adhikari, Guifang Jia, Marc B Bissonnette, Xinxiang Zhang, Yupei Zhao, Wei Zhang, Chuan He, Jie Liu
DNA modifications such as 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are epigenetic marks known to affect global gene expression in mammals. Given their prevalence in the human genome, close correlation with gene expression and high chemical stability, these DNA epigenetic marks could serve as ideal biomarkers for cancer diagnosis. Taking advantage of a highly sensitive and selective chemical labeling technology, we report here the genome-wide profiling of 5hmC in circulating cell-free DNA (cfDNA) and in genomic DNA (gDNA) of paired tumor and adjacent tissues collected from a cohort of 260 patients recently diagnosed with colorectal, gastric, pancreatic, liver or thyroid cancer and normal tissues from 90 healthy individuals...
September 19, 2017: Cell Research
https://www.readbyqxmd.com/read/28925153/-advances-on-chemical-constituents-and-pharmacological-activities-of-ceriops-genus
#16
Qing-Feng Guo, Lin Chen, Jing-Wei Ma, Yong Zhang
Plants of the genus Ceriops (Rhizophoraceae) consist of five species, which were widely distributed in tropical Asia, Eastern Africa and Oceania. So far,phytochemical studies showed that a total of 131 compounds including 120 terpenoids had been isolated from this genus, which exhibited anti-inflammatory, antihyperglycaemic, antitumor, anti-microbial, antioxidant, antifouling and antiviral activities. This article summarized the recent research progress of the chemical compositions and their pharmacological activities from the genus,which could provide reference for the development and utilization of the Ceriops plants...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925152/-study-on-botanical-pesticides-and-its-application-in-production-of-traditional-chinese-medicine
#17
REVIEW
Peng Zhang, Xi-Wen Li, Lin-Lin Dong, Shi-Lin Chen
The issues including excessive pesticide residues and heavy metal contamination have become the bottle-neck in the development of Chinese herbal medicines. Compared with traditional chemical pesticides, biological pesticides, especially botanical pesticides, are more safe and environment-friendly, which were beneficial to the quality improvement Chinese medicinal materials. Though there exists a weak basic research and it is hard for promotion and regulation, the policy of good and the desire for botanical pesticides will accelerate its development, and replace traditional chemical pesticides gradually...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925142/-research-progress-on-method-validation-of-near-infrared-spectroscopy-in-quantitative-analysis
#18
Yu Luo, Wen-Long Li, Hai-Bin Qu
Due to the advantages of fast and noninvasive, requiring almost no sample preparation, supplying chemical and physical information, near infrared (NIR) spectroscopy is widely used in the pharmaceutical industry. In the life cycle of an established analytical method, rigorous validation should be performed before routine use. However,there is no detailed experimental standards or decision rules for the NIR methods validation currently, and various approaches were applied to validate the established NIR quantification models in literatures...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925140/-near-infrared-spectroscopy-based-process-trajectory-technology-and-its-application-in-monitoring-and-controlling-of-traditional-chinese-medicine-manufacturing-process
#19
Wen-Long Li, Hai-Bin Qu
In this paper, the principle of NIRS (near infrared spectroscopy)-based process trajectory technology was introduced.The main steps of the technique include:① in-line collection of the processes spectra of different technics; ② unfolding of the 3-D process spectra;③ determination of the process trajectories and their normal limits;④ monitoring of the new batches with the established MSPC (multivariate statistical process control) models.Applications of the technology in the chemical and biological medicines were reviewed briefly...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925139/-rapid-identification-and-evaluation-of-chinese-materia-medica-quality-by-near-infrared-spectroscopy
#20
Gang Bai, Guo-Yu Ding, Yuan-Yuan Hou, Min Jiang, Jie Gao
In recent years, the research object of traditional Chinese medicine(TCM) analysis has not just been limited to the common analysis technology, but focused on the key relationship between chemical ingredients and traditional functions, including Chinese material medica (CMM) attributes, chemical substance and biological function. Near infrared spectroscopy (NIR) analysis technology, due to its unique advantages, has been developed rapidly in the field of pharmaceutical analysis, especially in the TCM analysis...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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