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https://www.readbyqxmd.com/read/28742625/online-sales-of-unscheduled-pharmaceutical-agents-a-case-report-of-tianeptine-use-in-the-united-states
#1
Swapnil Gupta, Ryan Wallace, Jordan Sloshower
: Tianeptine is a tricyclic antidepressant that stimulates mu-opioid receptors at high doses. It is marketed and used across Europe and Latin America as an antidepressant, but is not approved by the Food and Drug Administration for use in the United States. In the United States, tianeptine is sold through online health stores as a cognition enhancer, dietary supplement, or as research chemical. We report the case of a 36-year-old man with a history of major depressive disorder, responsive to sertraline, who turned to the unmonitored use of tianeptine purchased online to treat residual feelings of apathy and boredom...
July 24, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28742527/biotechnological-potential-of-insect-fatty-acid-modifying-enzymes
#2
Michal Tupec, Aleš Buček, Irena Valterová, Iva Pichová
There are more than one million described insect species. This species richness is reflected in the diversity of insect metabolic processes. In particular, biosynthesis of secondary metabolites, such as defensive compounds and chemical signals, encompasses an extraordinarily wide range of chemicals that are generally unparalleled among natural products from other organisms. Insect genomes, transcriptomes and proteomes thus offer a valuable resource for discovery of novel enzymes with potential for biotechnological applications...
July 25, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28742361/a-kinetic-dominated-charging-mechanism-within-representative-aqueous-electrolyte-based-electric-double-layer-capacitors
#3
Huachao Yang, Jinyuan Yang, Zheng Bo, Xia Chen, Xiaorui Shuai, Jing Kong, Jianhua Yan, Kefa Cen
The chemical nature of electrolytes has been demonstrated to play a pivotal role in charge storage of electric double-layer capacitors (EDLCs), whereas primary mechanisms are still partially resolved but controversial. In this work, a systematic exploration into EDL structures and kinetics of representative aqueous electrolytes is performed with numerical simulation and experimental research. Unusually, a novel charging mechanism exclusively predominated by kinetics is recognized, going beyond traditional views of manipulating capacitances preferentially via interfacial structural variations...
July 25, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28742329/selecting-dna-encoded-chemical-library-against-non-immobilized-proteins-using-a-ligate-crosslink-purify-strategy
#4
Bingbing Shi, Yuqing Deng, Peng Zhao, Xiaoyu Li
DNA-encoded chemical library (DEL) has recently emerged and become an important technology platform in biomedical research and drug discovery. DELs containing large numbers of compounds can be prepared and selected against biological targets to discover novel ligands and inhibitors. In practice, DELs are usually selected against purified and immobilized proteins using the typical "bind-wash-elute" protocol; however, selection methods compatible with non-immobilized proteins would be able to greatly expand the target scope of DELs beyond purified proteins to more complex and biologically relevant targets...
July 25, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28742092/cadmium-exposure-and-endometrial-cancer-risk-a-large-midwestern-u-s-population-based-case-control-study
#5
Jane A McElroy, Robin L Kruse, James Guthrie, Ronald E Gangnon, J David Robertson
Estrogen-mimicking chemicals, such as cadmium, may be associated with increased susceptibility to hormone-dependent cancers, though supporting data are sparse, particularly for endometrial cancer. The Health and Environmental Exposure Research (HEER) study worked with the Arkansas Central Cancer Registry, Iowa Cancer Registry and Missouri Cancer Registry to obtain names of women diagnosed with endometrial cancer who were willing to be contacted for participation in our case control study. Voter registration lists from Iowa and Missouri were used to randomly select similarly aged women as represented in the case population...
2017: PloS One
https://www.readbyqxmd.com/read/28742064/the-effect-of-biosilver-nanoparticles-on-different-bacterial-strains-metabolism-reflected-in-their-vocs-profiles
#6
Boguslaw Buszewski, Ileana Andreea Ratiu, Maciej Milanowski, Pawel Pomastowski, Tomasz Ligor
Silver nanoparticles use has spawned during the last years a growing interest for many researchers, due to their bacteriostatic and bactericidal properties and synergetic effects, when they are used together with antibiotics, for an increased efficiency and less adverse reactions in treatment of bacterial infections. GC-MS (gas chromatography coupled with mass spectrometry), which is considered "the golden standard" in chemical analysis has proven to be a reliable instrument, perfectly suitable for clinical analysis...
July 25, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28741979/systematic-review-of-the-literature-on-triclosan-and-health-outcomes-in-humans
#7
Michael Goodman, Daniel Q Naiman, Judy S LaKind
The ability of epidemiologic evidence to inform regulatory decisions is largely dependent on the coherence and quality of the published literature. This systematic review examines the quality and consistency of studies assessing health outcomes associated with exposure to triclosan (TCS), an antimicrobial chemical with a short physiologic half-life. We used elements of the Biomonitoring, Environmental Epidemiology, and Short-Lived Chemicals instrument to evaluate aspects of study quality. Each methodological domain - overall design, exposure assessment, and data analysis - was categorized according to three tiers where Tier 1 indicated the highest quality...
July 25, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28741748/porous-organic-polymers-for-post-combustion-carbon-capture
#8
REVIEW
Lanfang Zou, Yujia Sun, Sai Che, Xinyu Yang, Xuan Wang, Matheiu Bosch, Qi Wang, Hao Li, Mallory Smith, Shuai Yuan, Zachary Perry, Hong-Cai Zhou
One of the most pressing environmental concerns of our age is the escalating level of atmospheric CO2 . Intensive efforts have been made to investigate advanced porous materials, especially porous organic polymers (POPs), as one type of the most promising candidates for carbon capture due to their extremely high porosity, structural diversity, and physicochemical stability. This review provides a critical and in-depth analysis of recent POP research as it pertains to carbon capture. The definitions and terminologies commonly used to evaluate the performance of POPs for carbon capture, including CO2 capacity, enthalpy, selectivity, and regeneration strategies, are summarized...
July 25, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28741360/influence-of-chemical-mechanical-and-transport-processes-on-wellbore-leakage-from-geologic-co2-storage-reservoirs
#9
Susan A Carroll, Jaisree Iyer, Stuart D C Walsh
Wells are considered to be high-risk pathways for fluid leakage from geologic CO2 storage reservoirs, because breaches in this engineered system have the potential to connect the reservoir to groundwater resources and the atmosphere. Given these concerns, a few studies have assessed leakage risk by evaluating regulatory records, often self-reported, documenting leakage in gas fields. Leakage is thought to be governed largely by initial well-construction quality and the method of well abandonment. The geologic carbon storage community has raised further concerns because acidic fluids in the CO2 storage reservoir, alkaline cement meant to isolate the reservoir fluids from the overlying strata, and steel casings in wells are inherently reactive systems...
July 25, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28741223/citrulline-metabolism-in-plants
#10
REVIEW
Vijay Joshi, Alisdair R Fernie
Citrulline was chemically isolated more than 100 years ago and is ubiquitous in animals, plants, bacteria, and fungi. Most of the research on plant citrulline metabolism and transport has been carried out in Arabidopsis thaliana and the Cucurbitaceae family, particularly in watermelon which accumulates this non-proteinogenic amino acid to very high levels. Industrially, citrulline is produced via specially optimized microbial strains; however, the amounts present in watermelon render it an economically viable source providing that other high-value compounds can be co-extracted...
July 25, 2017: Amino Acids
https://www.readbyqxmd.com/read/28741213/geochemical-fractionation-and-pollution-assessment-of-zn-cu-and-fe-in-surface-sediments-from-shadegan-wildlife-refuge-southwest-of-iran
#11
Behnam Heidari Chaharlang, Alireza Riyahi Bakhtiari, Jahangard Mohammadi, Parvin Farshchi
This research focuses on the fractionation and distribution patterns of heavy metals (Zn, Cu, and Fe) in surficial sediments collected from Shadegan Wildlife Refuge, the biggest wetland in southern part of Iran, to provide an overall classification for the sources of metals in the study area using a sequential extraction method. For this purpose, a four-step sequential extraction technique was applied to define the partitioning of the metals into different geochemical phases of the sediment. The results illustrated that the average total level of Zn, Cu, and Fe in surface sediments were 55...
July 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28740866/distinct-properties-of-the-triplet-pair-state-from-singlet-fission
#12
M Tuan Trinh, Andrew Pinkard, Andrew B Pun, Samuel N Sanders, Elango Kumarasamy, Matthew Y Sfeir, Luis M Campos, Xavier Roy, X-Y Zhu
Singlet fission, the conversion of a singlet exciton (S1) to two triplets (2 × T1), may increase the solar energy conversion efficiency beyond the Shockley-Queisser limit. This process is believed to involve the correlated triplet pair state (1)(TT). Despite extensive research, the nature of the (1)(TT) state and its spectroscopic signature remain actively debated. We use an end-connected pentacene dimer (BP0) as a model system and show evidence for a tightly bound (1)(TT) state. It is characterized in the near-infrared (IR) region (~1...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28740616/unlocking-the-potential-of-established-products-toward-new-incentives-rewarding-innovation-in-europe
#13
Gabrielle Nayroles, Sandrine Frybourg, Sylvie Gabriel, Åsa Kornfeld, Fernando Antoñanzas-Villar, Jaime Espín, Claudio Jommi, Nello Martini, Gérard de Pouvourville, Keith Tolley, Jürgen Wasem, Mondher Toumi
Background: Many established products (EPs - marketed for eight years or more) are widely used off-label despite little evidence on benefit-risk ratio. This exposes patients to risks related to safety and lack of efficacy, and healthcare providers to liability. Introducing new indications for EPs may represent a high societal value; however, manufacturers rarely invest in R&D for EPs. The objective of this research was to describe incentives and disincentives for developing new indications for EPs in Europe and to investigate consequences of current policies...
2017: Journal of Market Access & Health Policy
https://www.readbyqxmd.com/read/28740383/enhanced-immunization-via-dissolving-microneedle-array-based-delivery-system-incorporating-subunit-vaccine-and-saponin-adjuvant
#14
Ji-Hui Zhao, Qi-Bo Zhang, Bao Liu, Xiang-Hua Piao, Yu-Lu Yan, Xiao-Ge Hu, Kuan Zhou, Yong-Tai Zhang, Nian-Ping Feng
PURPOSE: To enhance the immunogenicity of the model subunit vaccine, ovalbumin (OVA) was combined with platycodin (PD), a saponin adjuvant. To reduce the toxicity of PD, OVA, and adjuvant were loaded together into liposomes before being incorporated into a dissolving microneedle array. METHODS: OVA- and PD-loaded liposomes (OVA-PD-Lipos) were prepared using the film dispersion method. Their uptake behavior, toxicity to mouse bone marrow dendritic cells (BMDCs), and hemolytic activity to rabbit red blood cells (RBCs) were evaluated...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28738694/laccase-a-green-catalyst-for-the-biosynthesis-of-poly-phenols
#15
Jing Su, Jiajia Fu, Qiang Wang, Carla Silva, Artur Cavaco-Paulo
Laccases (benzene diol: oxidoreductases, EC 1.10.3.2) are able to catalyze the oxidation of various compounds containing phenolic and aniline structures using dissolved oxygen in water. Laccase structural features and catalytic mechanisms focused on the polymerization of aromatic compounds are reported. A description about the most recent research on the biosynthesis of chemicals and polymers is made. Selected applications of this technology are considered as well as the advantages, shortcomings and future needs related with the use of laccases...
July 24, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28738620/proteins-in-microbial-synthesis-of-selenium-nanoparticles
#16
Anna V Tugarova, Alexander A Kamnev
Biogenic formation of nano-sized particles composed of various materials (in particular, selenium) by live microorganisms is widespread in nature. This phenomenon has been increasingly attracting the attention of researchers over the last decade not only owing to a range of diverse applications of such nanoparticles (NPs) in nanobiotechnology, but also because of the specificity of methodologies and mechanisms of NPs formation related to "green synthesis". In this mini-review, recent data are discussed on the multifaceted role of proteins in the processes of microbial reduction of selenium oxyanions and the formation of Se NPs...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738173/simulating-the-meteorology-and-pm10-concentrations-in-arizona-dust-storms-with-the-weather-research-and-forecasting-model-with-chemistry-wrf-chem
#17
Peter Hyde, Alex Mahalov, Jialun Li
Nine dust storms in south-central Arizona, USA were simulated with the Weather Research and Forecasting with Chemistry model (WRF-Chem) at 2-km resolution. The windblown dust emission algorithm was the Air Force Weather Agency model. In comparison with ground-based PM10 observations, the model unevenly reproduces the dust storm events. The model adequately estimates the location and timing of the events, but it is unable to precisely replicate the magnitude and timing of the elevated hourly concentrations of particles 10 microns and smaller ([PM10])...
July 24, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28737831/royal-jelly-lipophilic-fraction-induces-antiproliferative-effects-on-sh-sy5y-human-neuroblastoma-cells
#18
Angelo Gismondi, Eleonora Trionfera, Lorena Canuti, Gabriele Di Marco, Antonella Canini
Royal jelly (RJ) is one the most important bee product because it strongly influences the larval development in the hive, including the queen bee. In literature, RJ is known for its antioxidant, immunoregulatory, antifungal, antibiotical, erythropoietic, hypoglycemic, anticholesteremic, antithyroidic, anti-osteoporotic and estrogenic properties. However, it is surprising how rare the scientific evidence about RJ antineoplastic capacity are. That being said, we investigated, for the first time, the in vitro bioactivity of six different RJs on the growth of three different mammalian cell lines: immortalized murine myoblasts (C2C12), human prostate cancer (PC3) and human neuroblastoma (SH-SY5Y)...
July 24, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28737731/study-on-chemical-profile-and-neuroprotective-activity-of-myrica-rubra-leaf-extract
#19
Pinghong Chen, Xianzong Lin, Ching-Hsu Yang, Xu Tang, Yu-Wei Chang, Weibing Zheng, Lianzhong Luo, Changan Xu, Yung-Husan Chen
The chemical profile of Myrica rubra (a native species in China) leaf extract was investigated by UPLC-PDA-HRMS, and the neuroprotective activity of two characteristic constituents, myricanol and myricetrin, was evaluated with N2a cells using H₂O₂-inducedoxidative challenge through a series of methods, e.g., MTT assay, ROS assay and [Ca(2+)]i assay. Among the 188 constituents detected in the extract of Myrica rubra leaf, 116 were identified definitely or tentatively by the comprehensive utilization of precise molecular weight and abundant multistage fragmentation information obtained by quadrupole orbitrap mass spectrometry...
July 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28737226/laser-induced-graphene-formation-on-wood
#20
Ruquan Ye, Yieu Chyan, Jibo Zhang, Yilun Li, Xiao Han, Carter Kittrell, James M Tour
Wood as a renewable naturally occurring resource has been the focus of much research and commercial interests in applications ranging from building construction to chemicals production. Here, a facile approach is reported to transform wood into hierarchical porous graphene using CO2 laser scribing. Studies reveal that the crosslinked lignocellulose structure inherent in wood with higher lignin content is more favorable for the generation of high-quality graphene than wood with lower lignin content. Because of its high electrical conductivity (≈10 Ω per square), graphene patterned on wood surfaces can be readily fabricated into various high-performance devices, such as hydrogen evolution and oxygen evolution electrodes for overall water splitting with high reaction rates at low overpotentials, and supercapacitors for energy storage with high capacitance...
July 24, 2017: Advanced Materials
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