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https://www.readbyqxmd.com/read/28449545/structural-variety-and-adsorptive-properties-of-mesoporous-silicas-with-immobilized-oligosaccharide-groups
#1
Iryna Trofymchuk, Nadiia Roik, Lyudmila Belyakova
In this research, we report on the synthesis of mesoporous silicas with various quantities of immobilized oligosaccharide groups and different pore ordering degree. The hydrothermal co-condensation of tetraethyl orthosilicate and β-cyclodextrin-containing organosilane in the presence of cetyltrimethylammonium bromide template was employed. The purpose of this investigation was to show the opportunity of increasing β-cyclodextrin content in silica matrix by changing the molar ratio of initial reagents during organosilane synthesis and to determine whether the enhancing of immobilized groups on the surface influences on model aromatic compound adsorption from water...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28449191/perceived-harms-and-benefits-of-tobacco-marijuana-and-electronic-vaporizers-among-young-adults-in-colorado-implications-for-health-education-and-research
#2
Lucy Popova, Emily Anne McDonald, Sohrab Sidhu, Rachel Barry, Tracey A Richers Maruyama, Nicolas M Sheon, Pamela M Ling
AIMS: To evaluate how young adults perceive and compare harms and benefits of marijuana and tobacco products in the context of a legal marijuana market in Colorado. DESIGN: Semi-structured qualitative interviews. SETTING: Denver, Colorado, USA. PARTICIPANTS: Thirty-two young adults (18-26 years old) who used tobacco/marijuana/vaporizers. Semi-structured interviews addressed perceived harms and benefits of various tobacco and marijuana products and personal experiences with these products...
April 27, 2017: Addiction
https://www.readbyqxmd.com/read/28448467/chemical-composition-and-biological-activities-of-mono-and-heterofloral-bee-pollen-of-different-geographical-origins
#3
Jucilene Silva Araújo, Emerson Dechechi Chambó, Maria Angélica Pereira de Carvalho Costa, Samira Maria Peixoto Cavalcante da Silva, Carlos Alfredo Lopes de Carvalho, Leticia M Estevinho
Recent research shows variations in pollen chemical constituents and, consequently, in their therapeutic properties. Mono and multifloral bee pollen extracts were investigated for antioxidant and enzyme inhibitory activity properties, phenolic compounds and fatty acid composition. Generally, Eucalyptus spp. and multifloral extracts exhibited potent inhibitory activity against α-amylase, acetylcholinesterase, tyrosinase, lipoxygenase, lipase and hyaluronidase. On the other hand, Miconia spp. demonstrated higher antihemolytic activity...
April 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28448044/generation-of-ipsc-derived-human-brain-organoids-to-model-early-neurodevelopmental-disorders
#4
Elke Gabriel, Jay Gopalakrishnan
The restricted availability of suitable in vitro models that can reliably represent complex human brain development is a significant bottleneck that limits the translation of basic brain research into clinical application. While induced pluripotent stem cells (iPSCs) have replaced the ethically questionable human embryonic stem cells, iPSC-based neuronal differentiation studies remain descriptive at the cellular level but fail to adequately provide the details that could be derived from a complex, 3D human brain tissue...
April 14, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447255/phenolic-compounds-volatiles-and-antioxidant-capacity-of-white-myrtle-berry-liqueurs
#5
Gabriele Serreli, Igor Jerković, Katarzyna Angelika Gil, Zvonimir Marijanović, Viviana Pacini, Carlo Ignazio Giovanni Tuberoso
The aim of this research was to evaluate the antioxidant capacity and physical-chemical characteristics of commercial white myrtle berry (Myrtus communis L. var. leucocarpa DC) liqueur (WMBL). The total phenolic (TP) content was measured spectrophotometrically, applying a modified Folin-Ciocalteu's method, and phenolic compounds were identified by high-performance liquid chromatography (HPLC) coupled with electrospray mass spectrometry, and quantified by HPLC coupled with ultraviolet/visible detection. The antioxidant capacities were evaluated by FRAP, CUPRAC, DPPH(•), and ABTS(•+) assays...
April 26, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28447138/-endocrine-disruptors-evidence-from-epidemiological-studies-necessitates-a-critical-review-of-model-systems
#6
REVIEW
M Hoffmann, S Gebauer, M Nüchter, R Baber, J Ried, M von Bergen, W Kiess
Endocrine disruptive chemicals (EDCs) cause adverse health effects through interaction with endocrine systems. They are classified by chemical structure, effects on specific endocrine systems, bioaccumulation, persistence in the environment, or clinically observable effects. For research of the complex mechanisms of action in the human body, only in vitro model systems have so far been available, that have insufficient high-throughput capacity, which makes risk evaluation more difficult. In addition, in industrial nations, living people are often exposed to mixtures of substances, with various effects...
April 26, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28446741/methodology-to-define-biological-reference-values-in-the-environmental-and-occupational-fields-the-contribution-of-the-italian-society-for-reference-values-sivr
#7
Maria Cristina Aprea, Maria Luisa Scapellato, Maria Carmen Valsania, Andrea Perico, Luigi Perbellini, Maria Cristina Ricossa, Marco Pradella, Sara Negri, Ivo Iavicoli, Piero Lovreglio, Fabiola Salamon, Maurizio Bettinelli, Pietro Apostoli
BACKGROUND: Biological reference values (RVs) explore the relationships between humans and their environment and habits. RVs are fundamental in the environmental field for assessing illnesses possibly associated with environmental pollution, and also in the occupational field, especially in the absence of established biological or environmental limits. OBJECTIVES: The Italian Society for Reference Values (SIVR) determined to test criteria and procedures for the definition of RVs to be used in the environmental and occupational fields...
April 21, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28446250/nanoparticles-based-on-essential-metals-and-their-phytotoxicity
#8
REVIEW
Branislav Ruttkay-Nedecky, Olga Krystofova, Lukas Nejdl, Vojtech Adam
Nanomaterials in agriculture are becoming popular due to the impressive advantages of these particles. However, their bioavailability and toxicity are key features for their massive employment. Herein, we comprehensively summarize the latest findings on the phytotoxicity of nanomaterial products based on essential metals used in plant protection. The metal nanoparticles (NPs) synthesized from essential metals belong to the most commonly manufactured types of nanomaterials since they have unique physical and chemical properties and are used in agricultural and biotechnological applications, which are discussed...
April 26, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28446160/hydro-ethanolic-leaf-extract-of-ziziphus-abyssinica-hochst-ex-a-rich-rhamnaceae-exhibits-anti-nociceptive-effects-in-murine-models
#9
Eric Boakye-Gyasi, Isaac Tabiri Henneh, Wonder Kofi Mensah Abotsi, Elvis Ofori Ameyaw, Eric Woode
BACKGROUND: Despite substantial advances in pain research and treatment, millions of people continue to suffer from pain and this has been attributed mainly to the unavailability of effective and safer analgesics. The use of plants as medicines is still widespread and plants constitute a large source of novel phytocompounds that might become leads for the discovery of newer, effective and safer alternatives. Various parts of Ziziphus abyssinica have been used in folk medicine in several African countries as painkillers...
April 26, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28446067/the-chemical-disruption-of-human-metabolism
#10
Stephen J Genuis, Edmond Kyrillos
BACKGROUND: Recent evidence highlights the reality of unprecedented human exposure to toxic chemical agents found throughout our environment - in our food and water supply, in the air we breathe, in the products we apply to our skin, in the medical and dental materials placed into our bodies, and even within the confines of the womb. With biomonitoring confirming the widespread bioaccumulation of myriad toxicants among population groups, expanding research continues to explore the pathobiological impact of these agents on human metabolism...
April 26, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28445602/identification-of-a-novel-mirna-that-increases-transient-protein-expression-in-combination-with-valproic-acid
#11
Hermann-Josef Meyer, Dorothea Reilly, Scott E Martin, Athena W Wong
Transient gene expression in mammalian cells is an efficient process to produce recombinant proteins for various research applications and large molecule therapeutics development. For the first time, we report a screen to identify human microRNAs (miRNAs) that increase titers after polyethylenimine (PEI) mediated transient transfection of a HEK293 cell line. From a library of 875 miRNAs, we identified 2 miRNAs, miR-26a-5p and miR-337-5p, that increased human IgG1 (huIgG1) yields by 50% and 25%, respectively...
April 26, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28445132/targeting-autophagic-cancer-stem-cells-to-reverse-chemoresistance-in-human-triple-negative-breast-cancer
#12
Guilhem Bousquet, Morad El Bouchtaoui, Tan Sophie, Christophe Leboeuf, Cédric de Bazelaire, Philippe Ratajczak, Sylvie Giacchetti, Anne de Roquancourt, Philippe Bertheau, Laurence Verneuil, Jean-Paul Feugeas, Marc Espié, Anne Janin
There is growing evidence for the role of cancer stem-cells in drug resistance, but with few in situ studies on human tumor samples to decipher the mechanisms by which they resist anticancer agents.Triple negative breast cancer (TNBC) is the most severe sub-type of breast cancer, occurring in younger women and associated with poor prognosis even when treated at a localized stage.We investigated here the relationship between complete pathological response after chemotherapy and breast cancer stem-cell characteristics in pre-treatment biopsies of 78 women with triple negative breast carcinoma (TNBC)...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28444952/similarity-in-volatile-communities-leads-to-increased-herbivory-and-greater-tropical-forest-diversity
#13
Tara Joy Massad, Marcílio Martins de Moraes, Casey Philbin, Celso Oliveira, Gerardo Cebrian Torrejon, Lydia Fumiko Yamaguchi, Christopher S Jeffrey, Lee A Dyer, Lora A Richards, Massuo Jorge Kato
A longstanding paradigm in ecology is that there are positive associations between herbivore diversity, specialization, and plant species diversity, with a focus on taxonomic diversity. However, phytochemical diversity is also an informative metric, as insect herbivores interact with host-plants not as taxonomic entities, but as sources of nutrients, primary metabolites, and mixtures of attractant and repellant chemicals. The present research examines herbivore responses to phytochemical diversity measured as volatile similarity in the tropical genus Piper...
April 26, 2017: Ecology
https://www.readbyqxmd.com/read/28444848/biologically-meaningful-scents-a-framework-for-understanding-predator-prey-research-across-disciplines
#14
Michael H Parsons, Raimund Apfelbach, Peter B Banks, Elissa Z Cameron, Chris R Dickman, Anke S K Frank, Menna E Jones, Ian S McGregor, Stuart McLean, Dietland Müller-Schwarze, Elisa E Sparrow, Daniel T Blumstein
Fear of predation is a universal motivator. Because predators hunt using stealth and surprise, there is a widespread ability among prey to assess risk from chemical information - scents - in their environment. Consequently, scents often act as particularly strong modulators of memory and emotions. Recent advances in ecological research and analytical technology are leading to novel ways to use this chemical information to create effective attractants, repellents and anti-anxiolytic compounds for wildlife managers, conservation biologists and health practitioners...
April 26, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28444605/recent-trends-of-modern-bacterial-insecticides-for-pest-control-practice-in-integrated-crop-management-system
#15
REVIEW
Pritam Chattopadhyay, Goutam Banerjee, Sayantan Mukherjee
Food security and safety are the major concern in ever expanding human population on the planet earth. Each and every year insect pests cause a serious damage in agricultural field that cost billions of dollars annually to farmers. The loss in term of productivity and high cost of chemical pesticides enhance the production cost. Irrespective use of chemical pesticides (such as Benzene hexachloride, Endosulfan, Aldicarb, and Fenobucarb) in agricultural field raised several types of environmental issues. Furthermore, continuous use of chemical pesticides creates a selective pressure which helps in emerging of resistance pest...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28444340/ligpargen-web-server-an-automatic-opls-aa-parameter-generator-for-organic-ligands
#16
Leela S Dodda, Israel Cabeza de Vaca, Julian Tirado-Rives, William L Jorgensen
The accurate calculation of protein/nucleic acid-ligand interactions or condensed phase properties by force field-based methods require a precise description of the energetics of intermolecular interactions. Despite the progress made in force fields, small molecule parameterization remains an open problem due to the magnitude of the chemical space; the most critical issue is the estimation of a balanced set of atomic charges with the ability to reproduce experimental properties. The LigParGen web server provides an intuitive interface for generating OPLS-AA/1...
April 21, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28443679/emerging-roles-of-carbonyl-sulfide-cos-in-chemical-biology-sulfide-transporter-or-gasotransmitter
#17
Andrea K Steiger, Yu Zhao, Michael D Pluth
SIGNIFICANCE: Carbonyl sulfide (COS) is the most prevalent sulfur-containing gas in Earth's atmosphere and plays important roles in the global sulfur cycle. COS has been implicated in origin of life peptide ligation, is the primary energy source for certain bacteria, and has been detected in mammalian systems. Despite this long and intertwined history with terrestrial biology, limited attention has focused on potential roles of COS as a biological mediator. Recent Advances. Although bacterial COS production is well documented, definitive sources of mammalian COS production have not been confirmed...
April 26, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28443432/marmite-may-help-regulate-healthy-brain-function
#18
(no author information available yet)
Eating foods rich in B vitamins - such as the yeast extract Marmite - can boost chemicals associated with healthy brain function, according to researchers.
April 26, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28443361/the-effect-of-alkali-on-the-product-distribution-from-black-liquor-conversion-under-supercritical-water
#19
Y Hawangchu, D Atong, V Sricharoenchaikul
Lignin in chemical pulping waste, or black liquor (BL), can be converted into various products via supercritical water gasification (SCWG). However, the inherited alkaline contents from the pulping chemicals may affect the product yields and properties. In this research, the influence of the residual alkali on the product distribution via SCWG of soda BL and kraft BL was evaluated. The SCWG was performed in a batch quartz reactor for 10 min at various temperatures (673, 773 and 873 K) and pressures (250, 300 and 400 bar)...
April 26, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28442740/deciphering-the-mode-of-action-of-cell-wall-inhibiting-antibiotics-using-metabolic-labeling-of-growing-peptidoglycan-in-streptococcus-pyogenes
#20
Atsushi Sugimoto, Asuka Maeda, Kaori Itto, Hirokazu Arimoto
Because of the scanty pipeline of antibiotics newly obtained from nature, chemical modification of established drugs is one of the major streams of current antibacterial research. Intuitive and easy-to-use assays are critical for identifying drug candidates with novel modes of action. In this study, we demonstrated that metabolic fluorescent staining of growing cell walls is a powerful tool for mode-of-action analyses of antibiotics using Streptococcus pyogenes. A set of major cell-wall-inhibiting antibiotics (bacitracin, D-cycloserine, flavomycin, oxacillin, ramoplanin, and vancomycin) was employed to validate the potential of the assay...
April 25, 2017: Scientific Reports
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