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https://www.readbyqxmd.com/read/27906535/schedules-of-controlled-substances-temporary-placement-of-furanyl-fentanyl-into-schedule-i-final-order
#1
(no author information available yet)
The Administrator of the Drug Enforcement Administration is issuing this final order to temporarily schedule the synthetic opioid, N-(1-phenethylpiperidin-4-yl)-N-phenylfuran-2-carboxamide (furanyl fentanyl), and its isomers, esters, ethers, salts and salts of isomers, esters and ethers, into schedule I pursuant to the temporary scheduling provisions of the Controlled Substances Act. This action is based on a finding by the Administrator that the placement of furanyl fentanyl into schedule I of the Controlled Substances Act is necessary to avoid an imminent hazard to the public safety...
November 29, 2016: Federal Register
https://www.readbyqxmd.com/read/27906508/co2-capture-with-ionic-liquids-ils-and-deep-eutectic-solvents-dess-a-new-generation-of-sorbents
#2
Shokat Sarmad, Jyri-Pekka Mikkola, Xiaoyan Ji
High cost and high energy penalty for carbon dioxide (CO2) uptake from flue gases are important obstacles in large-scale industrial applications, and developing efficient technology for CO2 capture from technic and economic points is crucial. Ionic liquids (ILs) show the potential for CO2 separation due to their inherent advantages and have been proposed as alternatives in order to overcome the drawbacks of conventional sorbents. Chemical modification of ILs to improve their performance in CO2 absorption has received more attention...
December 1, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27906399/unusual-reactivity-of-dithiol-protected-clusters-in-comparison-to-monothiol-protected-clusters-studies-using-ag51-bdt-19-tpp-3-and-ag29-bdt-12-tpp-4
#3
Atanu Ghosh, Debasmita Ghosh, Esma Khatun, Papri Chakraborty, Thalappil Pradeep
We report the synthesis and unique reactivity of a new green dithiol protected cluster (DTPC), Ag51(BDT)19(TPP)3 (BDT and TPP are 1,3-benzenedithiol and triphenylphosphine, respectively). The cluster composition was confirmed by electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) mass spectrometric studies as well as by other supporting data. Surprisingly, the chemical reactivity between this DTPC and Au25(SR)18 involves only metal ion exchange in Au25(SR)18 without any ligand exchange, while reactions between monothiol protected clusters (MTPCs) show both metal and ligand exchange, an example being the reaction between Ag25DMBT18 and Au25PET18 (where DMBT and PET are 2,4-dimethylbenzenethiol and phenylethanethiol, respectively)...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27906386/formation-of-surface-nanobubbles-on-nanostructured-substrates
#4
Lei Wang, Xingya Wang, Liansheng Wang, Jun Hu, Chun Lei Wang, Binyu Zhao, Xuehua Zhang, Renzhong Tai, Mengdong He, Liqun Chen, Lijuan Zhang
The nucleation and stability of nanoscale gas bubbles located at a solid/liquid interface are attracting significant research interest. It is known that the physical and chemical properties of the solid surface are crucial for the formation and properties of the surface nanobubbles. Herein, we experimentally and numerically investigated the formation of nanobubbles on nanostructured substrates. Two kinds of nanopatterned surfaces, namely, nanotrenches and nanopores, were fabricated using an electron beam lithography technique and used as substrates for the formation of nanobubbles...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27905978/schedules-of-controlled-substances-temporary-placement-of-u-47700-into-schedule-i-final-order
#5
(no author information available yet)
The Administrator of the Drug Enforcement Administration is issuing this final order to temporarily schedule the synthetic opioid, 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (also known as U-47700), and its isomers, esters, ethers, salts and salts of isomers, esters and ethers, into schedule I pursuant to the temporary scheduling provisions of the Controlled Substances Act. This action is based on a finding by the Administrator that the placement of U-47700 into schedule I of the Controlled Substances Act is necessary to avoid an imminent hazard to the public safety...
November 14, 2016: Federal Register
https://www.readbyqxmd.com/read/27905577/infrared-spectroscopy-and-spectroscopic-imaging-in-forensic-science
#6
REVIEW
Andrew V Ewing, Sergei G Kazarian
Infrared spectroscopy and spectroscopic imaging, are robust, label free and inherently non-destructive methods with a high chemical specificity and sensitivity that are frequently employed in forensic science research and practices. This review aims to discuss the applications and recent developments of these methodologies in this field. Furthermore, the use of recently emerged Fourier transform infrared (FT-IR) spectroscopic imaging in transmission, external reflection and Attenuated Total Reflection (ATR) modes are summarised with relevance and potential for forensic science applications...
December 1, 2016: Analyst
https://www.readbyqxmd.com/read/27903821/construction-of-a-minimal-genome-as-a-chassis-for-synthetic-biology
#7
REVIEW
Bong Hyun Sung, Donghui Choe, Sun Chang Kim, Byung-Kwan Cho
Microbial diversity and complexity pose challenges in understanding the voluminous genetic information produced from whole-genome sequences, bioinformatics and high-throughput '-omics' research. These challenges can be overcome by a core blueprint of a genome drawn with a minimal gene set, which is essential for life. Systems biology and large-scale gene inactivation studies have estimated the number of essential genes to be ∼300-500 in many microbial genomes. On the basis of the essential gene set information, minimal-genome strains have been generated using sophisticated genome engineering techniques, such as genome reduction and chemical genome synthesis...
November 30, 2016: Essays in Biochemistry
https://www.readbyqxmd.com/read/27903430/minimizing-the-risk-of-chemically-reactive-metabolite-formation-of-new-drug-candidates-implications-for-preclinical-drug-design
#8
Andreas Brink, Axel Pähler, Christoph Funk, Franz Schuler, Simone Schadt
Many pharmaceutical companies aim to reduce reactive metabolite formation by chemical modification at early stages of drug discovery. A practice often applied is the detection of stable trapping products of electrophilic intermediates with nucleophilic trapping reagents to guide rational structure-based drug design. This contribution delineates this strategy to minimize the potential for reactive metabolite formation of clinical candidates during preclinical drug optimization, exemplified by the experience at Roche over the past decade...
November 26, 2016: Drug Discovery Today
https://www.readbyqxmd.com/read/27902408/sequencing-rare-marine-actinomycete-genomes-reveals-high-density-of-unique-natural-product-biosynthetic-gene-clusters
#9
Michelle Antoinette Schorn, Mohammad M Alanjary, Kristen Aguinaldo, Anton Korobeynikov, Sheila Podell, Nastassia V Patin, Tommie Lincecum, Paul R Jensen, Nadine Ziemert, Bradley S Moore
Traditional natural product discovery methods have nearly exhausted the accessible diversity of microbial chemicals, making new sources and techniques paramount in the search for new molecules. Marine actinomycete bacteria have recently come into the spotlight as fruitful producers of structurally diverse secondary metabolites, and remain relatively untapped. In this study we sequenced twenty-one marine-derived actinomycete strains, rarely studied for their secondary metabolite potential and underrepresented in current genomic databases...
October 27, 2016: Microbiology
https://www.readbyqxmd.com/read/27901634/detection-of-nucleic-acid-modifications-by-chemical-reagents
#10
Matthias Heiss, Stefanie Kellner
Nucleic acids, especially RNA, naturally contain a diversity of chemically modified nucleosides. To understand the biological role of these modified nucleosides, nucleic acid scientists need tools to specifically label, detect and enrich modified nucleic acids. These tools comprise a diverse set of chemical reagents which have been established in the early years of nucleic acid research. Recent developments in high-throughput sequencing and mass spectrometry utilize these chemical labeling strategies to efficiently detect and localize modifications in nucleic acids...
November 30, 2016: RNA Biology
https://www.readbyqxmd.com/read/27901353/can-new-chemical-therapies-improve-the-management-of-multiple-sclerosis-in-children
#11
Emanuele D'Amico, Aurora Zanghì, Francesco Patti
Pediatric multiple sclerosis (MS) may represent up to 10% of all MS cases. Establishing the diagnosis of MS in a child is complicated by the limited diagnostic criteria and the possibility of significant overlap with acute disseminated encephalomyelitis. Areas covered: This review puts in perspective the potential possibilities given by new pharmacological agents in pediatric MS; focusing on the unmet needs in terms of research development in this field. Expert Opinion: The treatment landscape of MS has dramatically changed in the last 5 years...
November 30, 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27901056/rice-volatiles-lure-gravid-malaria-mosquitoes-anopheles-arabiensis
#12
Betelehem Wondwosen, Göran Birgersson, Emiru Seyoum, Habte Tekie, Baldwyn Torto, Ulrike Fillinger, Sharon R Hill, Rickard Ignell
Mosquito oviposition site selection is essential for vector population dynamics and malaria epidemiology. Irrigated rice cultivations provide ideal larval habitats for malaria mosquitoes, which has resulted in increased prevalence of the malaria vector, Anopheles arabiensis, in sub-Saharan Africa. The nature and origin of the cues regulating this behaviour are only now being elucidated. We show that gravid Anopheles arabiensis are attracted and oviposit in response to the odour present in the air surrounding rice...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900826/backbone-degradable-polymers-prepared-by-chemical-vapor-deposition
#13
Fan Xie, Xiaopei Deng, Domenic Kratzer, Kenneth C K Cheng, Christian Friedmann, Shuhua Qi, Luis Solorio, Joerg Lahann
Polymers prepared by chemical vapor deposition (CVD) polymerization have found broad acceptance in research and industrial applications. However, their intrinsic lack of degradability has limited wider applicability in many areas, such as biomedical devices or regenerative medicine. Herein, we demonstrate, for the first time, a backbone-degradable polymer directly synthesized via CVD. The CVD co-polymerization of [2.2]para-cyclophanes with cyclic ketene acetals, specifically 5,6-benzo-2-methylene-1,3-dioxepane (BMDO), results in well-defined, hydrolytically degradable polymers, as confirmed by FTIR spectroscopy and ellipsometry...
November 30, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27900822/stimulus-responsive-nanoparticles-and-associated-reversible-polymorphism-via-polymerization-induced-self-assembly-pisa
#14
Yiwen Pei, Andrew B Lowe, Peter J Roth
Polymerization-induced self-assembly (PISA) is an extremely versatile method for the in situ preparation of soft-matter nanoparticles of defined size and morphologies at high concentrations, suitable for large-scale production. Recently, certain PISA-prepared nanoparticles have been shown to exhibit reversible polymorphism ("shape-shifting"), typically between micellar, worm-like, and vesicular phases (order-order transitions), in response to external stimuli including temperature, pH, electrolytes, and chemical modification...
November 30, 2016: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/27900736/preparation-of-horizontal-single-walled-carbon-nanotubes-arrays
#15
REVIEW
Pan Li, Jin Zhang
The synthesis of SWNTs has achieved great success with the development of synthetic methodologies. From the viewpoint of exploiting the exceptional electrical properties of single-walled carbon nanotubes (SWNTs) in advanced applications, one of the most difficult challenges is how to assemble the SWNTs with high degrees of alignment and purity in electronic conducting (mainly semiconducting) behavior into functional nanodevices. Numerous approaches have been developed to reach this goal, which could be divided into two categories...
December 2016: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/27900698/mining-microbial-signals-for-enhanced-biodiscovery-of-secondary-metabolites
#16
F Jerry Reen, Jose A Gutiérrez-Barranquero, Fergal O'Gara
The advent of metagenomics based biodiscovery has provided researchers with previously unforeseen access to the rich tapestry of natural bioactivity that exists in the biosphere. Unhindered by the "culturable bottleneck" that has severely limited the translation of the genetic potential that undoubtedly exists in nature, metagenomics nonetheless requires ongoing technological developments to maximize its efficacy and applicability to the discovery of new chemical entities.Here we describe methodologies for the detection and isolation of quorum sensing (QS) signal molecules from metagenomics libraries...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27900421/spectroscopic-sensors-for-in-line-bioprocess-monitoring-in-research-and-pharmaceutical-industrial-application
#17
REVIEW
Jens Claßen, Florian Aupert, Kenneth F Reardon, Dörte Solle, Thomas Scheper
The use of spectroscopic sensors for bioprocess monitoring is a powerful tool within the process analytical technology (PAT) initiative of the US Food and Drug Administration. Spectroscopic sensors enable the simultaneous real-time bioprocess monitoring of various critical process parameters including biological, chemical, and physical variables during the entire biotechnological production process. This potential can be realized through the combination of spectroscopic measurements (UV/Vis spectroscopy, IR spectroscopy, fluorescence spectroscopy, and Raman spectroscopy) with multivariate data analysis to obtain relevant process information out of an enormous amount of data...
November 30, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27900404/erasing-borders-a-brief-chronicle-of-early-synthetic-biology
#18
REVIEW
Juli Peretó
Synthetic Biology is currently presented as an emergent field involving the application of engineering principles to living matter. However, the scientific pursuit of making life in a laboratory is not new and has been the ultimate, if somewhat distant, aim of the origin-of-life research program for many years. Actually, over a century ago, the idea that the synthesis of life was indispensable to fully understand its nature already appealed to material scientists and evolutionists alike. Jacques Loeb proposed a research program from an engineering standpoint, following a synthetic method (experimental abiogenesis) and based on his mechanist vision of living beings, which he considered true chemical machines...
November 30, 2016: Journal of Molecular Evolution
https://www.readbyqxmd.com/read/27899918/mechanistic-basis-of-antimicrobial-actions-of-silver-nanoparticles
#19
REVIEW
Tikam Chand Dakal, Anu Kumar, Rita S Majumdar, Vinod Yadav
Multidrug resistance of the pathogenic microorganisms to the antimicrobial drugs has become a major impediment toward successful diagnosis and management of infectious diseases. Recent advancements in nanotechnology-based medicines have opened new horizons for combating multidrug resistance in microorganisms. In particular, the use of silver nanoparticles (AgNPs) as a potent antibacterial agent has received much attention. The most critical physico-chemical parameters that affect the antimicrobial potential of AgNPs include size, shape, surface charge, concentration and colloidal state...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27899660/cebs-a-comprehensive-annotated-database-of-toxicological-data
#20
Isabel A Lea, Hui Gong, Anand Paleja, Asif Rashid, Jennifer Fostel
The Chemical Effects in Biological Systems database (CEBS) is a comprehensive and unique toxicology resource that compiles individual and summary animal data from the National Toxicology Program (NTP) testing program and other depositors into a single electronic repository. CEBS has undergone significant updates in recent years and currently contains over 11 000 test articles (exposure agents) and over 8000 studies including all available NTP carcinogenicity, short-term toxicity and genetic toxicity studies...
November 28, 2016: Nucleic Acids Research
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