keyword
MENU ▼
Read by QxMD icon Read
search

Research chemicals

keyword
https://www.readbyqxmd.com/read/28088583/environmental-carcinogenesis-and-ph-homeostasis-not-only-a-matter-of-dysregulated-metabolism
#1
REVIEW
Kévin Hardonniere, Laurence Huc, Odile Sergent, Jørn A Holme, Dominique Lagadic-Gossmann
According to the World Health Organization, around 20% of all cancers would be due to environmental factors. Among these factors, several chemicals are indeed well recognized carcinogens. The widespread contaminant benzo[a]pyrene (B[a]P), an often used model carcinogen of the polycyclic aromatic hydrocarbons' family, has been suggested to target most, if not all, cancer hallmarks described by Hanahan and Weinberg. It is classified as a group I carcinogen by the International Agency for Research on Cancer; however, the precise intracellular mechanisms underlying its carcinogenic properties remain yet to be thoroughly defined...
January 11, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28088277/immunoassays-of-chemically-modified-polysaccharides-glycans-in-glycoproteins-and-ribose-in-nucleic-acids
#2
Slađana Strmečki, Mojmír Trefulka, Pavlína Zatloukalová, Michal Durech, Borivoj Vojtesek, Emil Paleček
Glycosylation of proteins plays an important role in health and diseases. At present new simple and inexpensive methods of glycoprotein analysis are sought. We developed a monoclonal antibody Manost 2.1 in mice after immunization with the adduct of mannan with Os(VI)temed complex (temed is N,N,N',N'-tetramethylethylenediamine). The specificity of this antibody to different biomolecules treated with Os(VI)temed was tested using dot blot immunoassay. Manost 2.1 showed specificity toward Os(VI)temed-modified polysaccharides, glycoproteins and ribonucleotide at the 3'-end in DNA...
February 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28088099/protein-templated-synthesis-of-metal-based-nanomaterials
#3
REVIEW
Arnout Rd Voet, Jeremy Rh Tame
There is currently intense interest in using protein scaffolds to prepare uniform nanometre-sized clusters of metals or other inorganic material for use as sensors, imaging agents, drugs, magnetic materials or catalysts. Non-templated chemical synthesis of such clusters often results in a product of variable size and quality, but protein molecules have proved adept at nucleating and stabilizing precise nanoclusters of various kinds. Although much research has focused on natural proteins, such as the iron-storage protein ferritin, recent developments in protein design have allowed entirely novel, symmetrical proteins to be used as templates for the first time...
January 11, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28087526/rapid-enrichment-of-dehalococcoides-like-bacteria-by-partial-hydrophobic-separation
#4
Hanna R Temme, Kipp Sande, Tao Yan, Paige J Novak
: Organohalide respiring bacteria can be difficult to enrich and isolate, which can limit research on these important organisms. The goal of this research was to develop a method to rapidly (minutes to days) enrich these organisms from a mixed community. The method presented is based on the hypothesis that organohalide respiring bacteria would be more hydrophobic than other bacteria as they dehalogenate hydrophobic compounds. The developed method tests this hypothesis by separating a portion of putative organohalide respiring bacteria, those phylogenetically related to Dehalococcoides mccartyi, at the interface between a hydrophobic organic solvent and aqueous media...
January 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28087444/the-mechanistic-role-of-chemically-diverse-metal-ions-in-the-induction-of-autophagy
#5
REVIEW
Sumit Sahni, Dong-Hun Bae, Patric Jansson, Des Richardson
Autophagy is an evolutionary conserved cellular catabolic degradation process in response to stress which involves lysosomal degradation of unnecessary or damaged organelles and misfolded proteins. This is primarily a pro-survival pathway providing the cell with essential nutrients during stressful conditions. There are number of essential metal ions, which are required for normal physiological functioning of cells. Studies have shown that autophagy can be regulated by cellular metal ion concentrations. On the other hand, autophagy is also shown to regulate intracellular levels of certain metal ions...
January 10, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28087294/bioactive-metabolites-of-docosahexaenoic-acid
#6
REVIEW
Ondrej Kuda
Docosahexaenoic acid (DHA) is an essential fatty acid that is recognized as a beneficial dietary constituent and as a source of the anti-inflammatory specialized proresolving mediators (SPM): resolvins, protectins and maresins. Apart from SPMs, other metabolites of DHA also exert potent biological effects. This article summarizes current knowledge on the metabolic pathways involved in generation of DHA metabolites. Over 70 biologically active metabolites have been described, but are often discussed separately within specific research areas...
January 10, 2017: Biochimie
https://www.readbyqxmd.com/read/28087007/manipulating-the-microbiome
#7
Tammy L Sirich, Timothy W Meyer
The application of molecular methods has provided a new picture of the colon microbial flora, or microbiome. The microbiome has been found to be a complex ecosystem with multiple influences on its human host. In renal medicine, interest has focused on the microbiome as a source of toxic waste chemicals and a stimulant to unwanted systemic inflammation. Early attempts to manipulate the microbiome have yielded limited benefit, but further research is strongly motivated.
February 2017: Kidney International
https://www.readbyqxmd.com/read/28081017/lattice-parameters-guide-superconductivity-in-iron-arsenides
#8
Lance M N Konzen, Athena S Sefat
The discovery of superconducting materials has led to their use in technological marvels such as magnetic-field sensors in MRI machines, powerful research magnets, short transmission cables, and high-speed trains. Despite such applications, the uses of superconductors are not widespread because they function much below room-temperature, hence the costly cooling. Since the discovery of Cu- and Fe-based high-temperature superconductors (HTS), much intense effort has tried to explain and understand the superconducting phenomenon...
January 12, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28080202/chemical-probes-targeting-epigenetic-proteins-applications-beyond-oncology
#9
Suzanne Ackloo, Peter J Brown, Susanne Müller
Epigenetic chemical probes are potent, cell-active, small molecule inhibitors and antagonists of specific domains in a protein; they have been indispensable for studying bromodomains and protein methyltransferases. The Structural Genomics Consortium (SGC), comprising scientists from academic and pharmaceutical laboratories, has generated most of the current epigenetic chemical probes. Moreover, the SGC has shared about four thousand aliquots of these probes, which have been used primarily for phenotypic profiling or to validate targets in cell lines or primary patient samples cultured in vitro...
January 12, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28080037/global-metabolic-engineering-of-glycolytic-pathway-via-multi-copy-integration-in-saccharomyces-cerevisiae
#10
Ryosuke Yamada, Kazuki Wakita, Hiroyasu Ogino
The use of renewable feedstocks for producing biofuels and bio-based chemicals by engineering metabolic pathways of yeast Saccharomyces cerevisiae has recently become an attractive option. Many researchers attempted to increase glucose consumption rate by overexpressing some glycolytic enzymes because most target bio-based chemicals are derived through glycolysis. However these attempts have met with little success. In this study, to create a S. cerevisiae strain with high glucose consumption rate, we used multi-copy integration to develop a global metabolic engineering strategy...
January 12, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28078991/vegetable-organosulfur-compounds-and-their-health-promoting-effects
#11
Spyridon A Petropoulos, Francesco Di Gioia, Georgia Ntatsi
BACKGROUND: Trends in modern pharmaceutical science show an increase in demand for new drugs and diet supplements derived from natural products, while during the last decades, great research is conducted regarding the natural compounds and their medicinal and bioactive properties. Organosulfur compounds are present in many plants and their bioactive properties have been used in folk and traditional medicine throughout the centuries. Not until recently, modern science confirmed and revealed the chemical compounds that are responsible for these properties, the chemistry involved in their biosynthesis and the main mechanisms of action...
January 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28078982/phytochemicals-a-novel-and-prominent-source-of-anti-cancer-drugs-against-colorectal-cancer
#12
Ravikiran Mahadevappa, Hang Fai Kwok
Colorectal cancer (CRC) is a malignant disease whose incidence and mortality rates are greatly influenced by environmental factors. Under-treatment of CRC such as a poor diagnostic evaluation, less aggressive surgery, less intensive chemotherapy results in metastasizing of the primary tumor cells and recurrence of cancer. Prolonged chemotherapy treatment against cancer is hazardous to the patients, which also limits its use in cancer therapy. Current research in developing a novel anti-cancer agent, direct towards finding a better anti-metastatic and an anti-invasive drug with reduced side effects...
January 12, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28078718/fabric-based-alkaline-direct-formate-microfluidic-fuel-cells
#13
Kryls Domalaon, Catherine Tang, Alex Mendez, Franky Bernal, Krutarth Purohit, Linda Pham, John Haan, Frank A Gomez
Fabric-based microfluidic fuel cells (MFCs) serve as a novel, cost-efficient alternative to traditional FCs and batteries, since fluids naturally travel across fabric via capillary action, eliminating the need for an external pump and lowering production and operation costs. Building on previous research with Y-shaped paper-based MFCs, fabric-based MFCs mitigate fragility and durability issues caused by long periods of fuel immersion. In the present work we describe a microfluidic fabric-based direct formate fuel cell (DFFC), with 5 M potassium formate and 30% hydrogen peroxide as the anode fuel and cathode oxidant, respectively...
January 12, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28078392/carbon-footprint-assessment-of-western-australian-groundwater-recycling-scheme
#14
Andrew Simms, Stacey Hamilton, Wahidul K Biswas
This research has determined the carbon footprint or the carbon dioxide equivalent (CO2 eq) of potable water production from a groundwater recycling scheme, consisting of the Beenyup wastewater treatment plant, the Beenyup groundwater replenishment trial plant and the Wanneroo groundwater treatment plant in Western Australia, using a life cycle assessment approach. It was found that the scheme produces 1300 tonnes of CO2 eq per gigalitre (GL) of water produced, which is 933 tonnes of CO2 eq higher than the desalination plant at Binningup in Western Australia powered by 100% renewable energy generated electricity...
January 11, 2017: Environmental Management
https://www.readbyqxmd.com/read/28078073/soft-encapsulation-of-flexible-electrical-stimulation-implant-challenges-and-innovations
#15
Adrien Debelle, Laura Hermans, Maxime Bosquet, Sam Dehaeck, Laurent Lonys, Benoit Scheid, Antoine Nonclercq, Anne Vanhoestenberghe
In this document we discuss the main challenges encountered when producing flexible electrical stimulation implants, and present our approach to solving them for prototype production. We include a study of the optimization of the flexible PCB design, the selection of additive manufacturing materials for the mold, and the chemical compatibility of the different materials. Our approach was tested on a flexible gastro-stimulator as part of the ENDOGES research program.
September 15, 2016: European Journal of Translational Myology
https://www.readbyqxmd.com/read/28077884/chemical-vs-physical-acceleration-of-cement-hydration
#16
Dale P Bentz, Franco Zunino, Didier Lootens
Cold weather concreting often requires the use of chemical accelerators to speed up the hydration reactions of the cement, so that setting and early-age strength development will occur in a timely manner. While calcium chloride (dihydrate - CaCl2·2H2O) is the most commonly used chemical accelerator, recent research using fine limestone powders has indicated their high proficiency for physically accelerating early-age hydration and reducing setting times. This paper presents a comparative study of the efficiency of these two approaches in accelerating hydration (as assessed via isothermal calorimetry), reducing setting times (Vicat needle), and increasing early-age mortar cube strength (1 d and 7 d)...
November 2016: Concr Int
https://www.readbyqxmd.com/read/28077626/low-dose-or-low-dose-rate-ionizing-radiation-induced-bioeffects-in-animal-models
#17
REVIEW
Feng Ru Tang, Weng Keong Loke, Boo Cheong Khoo
Animal experimental studies indicate that acute or chronic low-dose ionizing radiation (LDIR) (≤100 mSv) or low-dose-rate ionizing radiation (LDRIR) (<6 mSv/h) exposures may be harmful. It induces genetic and epigenetic changes and is associated with a range of physiological disturbances that includes altered immune system, abnormal brain development with resultant cognitive impairment, cataractogenesis, abnormal embryonic development, circulatory diseases, weight gain, premature menopause in female animals, tumorigenesis and shortened lifespan...
January 10, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28076995/biosurfactants-in-cosmetic-formulations-trends-and-challenges
#18
X Vecino, J M Cruz, A B Moldes, L R Rodrigues
Cosmetic products play an essential role in everyone's life. People everyday use a large variety of cosmetic products such as soap, shampoo, toothpaste, deodorant, skin care, perfume, make-up, among others. The cosmetic industry encompasses several environmental, social and economic impacts that are being addressed through the search for more efficient manufacturing techniques, the reduction of waste and emissions and the promotion of personal hygiene, contributing to an improvement of public health and at the same time providing employment opportunities...
January 12, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28076938/transmission-electron-microscopy-for-nanomedicine-novel-applications-for-long-established-techniques
#19
Manuela Malatesta
During the last twenty years, the research in nanoscience and nanotechnology has dramatically increased and, in the last decade, the interest has progressively been oriented towards biomedical applications, giving rise to a new field termed nanomedicine. Transmis - sion electron microscopy is a valuable technique not only for the thorough physico-chemical characterization of newly synthesized nanoparticulates, but especially to explore the effects of nanocomposites on biological systems, providing essential information for the development of efficient therapeutic and diagnostic strategies...
December 9, 2016: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/28076644/main-mental-disorders-in-crack-cocaine-users-treated-at-psychosocial-care-centers-for-alcohol-and-drugs-in-the-city-of-recife-brazil
#20
Antonio Gomes de Castro, Diego César Nunes da Silva, Magda da Silva Figueiroa
Introduction: Brazil's Northeast region has the highest crack-cocaine consumption in the country. Crack-cocaine has more intense effects than cocaine powder and can cause greater chemical dependence. Psychosocial Care Centers for Alcohol and Drugs (CAPSad) are public health services that provide treatment for drug dependence. It is common for drug users, and particularly crack-cocaine users, to develop mental disorders. Objective: To evaluate the most common mental disorders in crack-cocaine dependents in treatment at CAPSad in the city of Recife, Brazil...
October 2016: Trends in Psychiatry and Psychotherapy
keyword
keyword
51088
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"