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https://www.readbyqxmd.com/read/29781377/aluminium-phosphide-poisoning-resulting-in-cardiac-arrest-successful-treatment-with-extracorporeal-cardiopulmonary-resuscitation-ecpr-a-case-report
#1
Juan Lehoux, Zachary Hena, Megan McCabe, Giles Peek
Aluminium phosphide (AP) is a pesticide used against rodents and insects. Exposure of AP to water releases phosphine gas. Phosphine is a highly toxic mitochondrial poison to which there is no known antidote. We report a case of a 3-year-old female with accidental home exposure to AP, which resulted in cardiac arrest, who was successfully supported with extracorporeal membrane oxygenation (ECMO).
May 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29738800/is-initial-rhythm-in-ohca-a-predictor-of-preceding-no-flow-time-implications-for-bystander-response-and-ecpr-candidacy-evaluation
#2
Xavier Tanguay-Rioux, Brian Grunau, Robert Neumar, John Tallon, Robert Boone, Jim Christenson
OBJECTIVE: Shockable cardiac rhythms are associated with improved outcomes among out-of-hospital cardiac arrests (OHCA). Initial cardiac rhythm may also be predictive of a short preceding no-flow duration. We examined the relationship between no-flow duration and initial cardiac rhythm, which may demonstrate the urgency in rescuer response and assist with candidacy evaluation for extracorporeal-cardiopulmonary resuscitation (ECPR). METHODS: We examined consecutive adult OHCA's identified by a prospective registry in British Columbia (2005-2016)...
May 5, 2018: Resuscitation
https://www.readbyqxmd.com/read/29738799/early-ecpr-for-out-of-hospital-cardiac-arrest-best-practice-in-2018
#3
Alice Hutin, Mamoun Abu-Habsa, Brian Burns, Steve Bernard, Joe Bellezzo, Zack Shinar, Ervigio Corral Torres, Pierre-Yves Gueugniaud, Pierre Carli, Lionel Lamhaut
No abstract text is available yet for this article.
May 5, 2018: Resuscitation
https://www.readbyqxmd.com/read/29737259/refractory-out-of-hospital-cardiac-arrest
#4
Madhan Shanmugasundaram, Kapildeo Lotun
Refractory out of hospital cardiac arrest is a common problem that is associated with poor overall survival rates and neurological outcomes. There are various definitions that have been used but the most accepted one is cardiac arrest that requires more than 10 minutes of cardiopulmonary resuscitation (CPR) efforts or more than 3 defibrillation attempts. There have been different pharmacologic and non-pharmacologic therapies that were studied in these patients. None of the antiarrhythmic or vasopressor medications have been consistently shown to improve survival or neurological outcomes in this subset of patients...
May 7, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29733006/barriers-and-opportunities-related-to-extracorporeal-cardiopulmonary-resuscitation-for-out-of-hospital-cardiac-arrest-in-canada-a-report-from-the-first-meeting-of-the-canadian-ecpr-research-working-group
#5
Steven C Brooks, Sam D Shemie, Sylvia Torrance, Laura Hornby, Clay Gillrie, Brian Grunau, A Dave Nagpal, Andrew Baker, Jim Christenson, John Gill, Laurie Morrison
For a French translation of the executive summary, please see the Supplementary Material at DOI: 10.107/cem.2017.429.
May 7, 2018: CJEM
https://www.readbyqxmd.com/read/29706060/variability-of-extracorporeal-cardiopulmonary-resuscitation-utilization-for-refractory-adult-out-of-hospital-cardiac-arrest-an-international-survey-study
#6
Patrick J Coppler, Benjamin S Abella, Clifton W Callaway, Minjung Kathy Chae, Seung Pill Choi, Jonathan Elmer, Won Young Kim, Young-Min Kim, Michael Kurz, Joo Suk Oh, Joshua C Reynolds, Jon C Rittenberger, Kelly N Sawyer, Chun Song Youn, Byung Kook Lee, David F Gaieski
Objective: A growing interest in extracorporeal cardiopulmonary resuscitation (ECPR) as a rescue strategy for refractory adult out-of-hospital cardiac arrest (OHCA) currently exists. This study aims to determine current standards of care and practice variation for ECPR patients in the USA and Korea. Methods: In December 2015, we surveyed centers from the Korean Hypothermia Network (KORHN) Investigators and the US National Post-Arrest Research Consortium (NPARC) on current targeted temperature management and ECPR practices...
April 30, 2018: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/29626610/health-related-quality-of-life-after-extracorporeal-cardiopulmonary-resuscitation-in-refractory-cardiac-arrest
#7
T Spangenberg, J Schewel, A Dreher, F Meincke, E Bahlmann, H van der Schalk, F Kreidel, C Frerker, M Stoeck, B Bein, K-H Kuck, A Ghanem
BACKGROUND: Recent data identifies extracorporeal cardio-pulmonary resuscitation (eCPR) as a potential addendum of conventional cardiopulmonary-resuscitation (cCPR) in highly specified circumstances and selected patients. However, consented criteria indicating eCPR are lacking. Therefore we provide first insights into the health-related quality of life (HRQoL) outcomes of patients treated with eCPR in a real world setting. METHODS: Retrospective single-center experience of 60 consecutive patients treated with eCPR between 01/2014 and 06/2016 providing 1-year survival- and HRQoL data obtained through the Short-Form 36 Survey (SF-36) after refractory out-of-hospital- (OHCA) and in-hospital cardiac arrest (IHCA) of presumed cardiac etiology...
April 4, 2018: Resuscitation
https://www.readbyqxmd.com/read/29587810/pre-hospital-extra-corporeal-cardiopulmonary-resuscitation
#8
REVIEW
Ben Singer, Joshua C Reynolds, David J Lockey, Ben O'Brien
Survival from out-of-hospital cardiac arrest (OHCA) has remained low despite advances in resuscitation science. Hospital-based extra-corporeal cardiopulmonary resuscitation (ECPR) is a novel use of an established technology that provides greater blood flow and oxygen delivery during cardiac arrest than closed chest compressions. Hospital-based ECPR is currently offered to selected OHCA patients in specialized centres. The interval between collapse and restoration of circulation is inversely associated with good clinical outcomes after ECPR...
March 27, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29573754/beyond-the-limits-ecpr-in-putative-fatal-circumstances
#9
Ingo Graeff, Sylvia Schacher, Stefan Lenkeit, Catherine N Widmann, Jens-Christian Schewe
The eligibility criteria for applying extracorporeal cardiopulmonary resuscitation (ECPR) in patients with cardiac arrest are currently unclear. For those patients with hypothermic cardiac arrest, the European Resuscitation Council (ERC) Guidelines recommend considering ECPR only for patients with potassium <8 mmol/L and a body temperature below 32°C, whereas the American Heart Association Guidelines (AHA) do not express this in a specific manner. We report the case of an urban unwitnessed out-of-hospital cardiac arrest patient found with her head immersed in water at a temperature of 23°C...
March 25, 2018: CJEM
https://www.readbyqxmd.com/read/29560009/refractory-ventricle-arrhythmias-alternating-with-pulseless-electrical-activity-in-a-young-woman-rescued-by-extracorporeal-cardiopulmonary-resuscitation
#10
Ilona Lálová, Lucie Filipovská, Hana Skalická, Ondřej Šmíd, Aleš Linhart, Helena Kollárová, Jan Bělohlávek
Introduction: Extracorporeal cardiopulmonary resuscitation (ECPR) is a challenging approach for treating refractory out-of-hospital cardiac arrest (OHCA). Case Presentation: The authors describe a case of a 40-year-old Caucasian female who suffered from refractory OHCA, was admitted to a hospital while receiving ongoing cardiopulmonary resuscitation, and was connected to venoarterial extracorporeal membrane oxygenation 73 minutes after collapse. Ventricular tachyarrhythmias alternating with pulseless electrical activity resolved after eight hours...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/29531316/rapid-real-time-pathology-review-for-ecog-acrin-1412-a-novel-and-successful-paradigm-for-future-lymphoma-clinical-trials-in-the-precision-medicine-era
#11
Rebecca L King, Grzegorz S Nowakowski, Thomas E Witzig, David W Scott, Richard F Little, Fangxin Hong, Randy D Gascoyne, Brad S Kahl, William R Macon
ECOG/ACRIN 1412 (E1412) is a randomized, phase II open-label study of lenalidomide/RCHOP vs. RCHOP alone in adults with newly diagnosed de novo diffuse large B-cell lymphoma (DLBCL) and requires NanoString gene expression profiling (GEP) for cell-of-origin testing. Because of high ineligibility rate on retrospective expert central pathology review (ECPR), real-time (RT) ECPR was instituted to confirm diagnosis and ensure adequate tissue for GEP prior to study enrollment. Goal was notification of eligibility within 2 working days (WD)...
February 28, 2018: Blood Cancer Journal
https://www.readbyqxmd.com/read/29475481/error-covariance-penalized-regression-a-novel-multivariate-model-combining-penalized-regression-with-multivariate-error-structure
#12
Franco Allegrini, Jez W B Braga, Alessandro C O Moreira, Alejandro C Olivieri
A new multivariate regression model, named Error Covariance Penalized Regression (ECPR) is presented. Following a penalized regression strategy, the proposed model incorporates information about the measurement error structure of the system, using the error covariance matrix (ECM) as a penalization term. Results are reported from both simulations and experimental data based on replicate mid and near infrared (MIR and NIR) spectral measurements. The results for ECPR are better under non-iid conditions when compared with traditional first-order multivariate methods such as ridge regression (RR), principal component regression (PCR) and partial least-squares regression (PLS)...
June 29, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29440824/extracorporeal-membrane-oxygenation-in-pediatric-cardiac-surgery-a-retrospective-review-of-trends-and-outcomes-in-scotland
#13
Maziar Khorsandi, Mark Davidson, Omar Bouamra, Andrew McLean, Kenneth MacArthur, Ida Torrance, Gillian Wylie, Ed Peng, Mark Danton
Introduction: Around 3.2%-8.4% of patients receive venoarterial (VA) extracorporeal membrane oxygenation (ECMO) support after pediatric cardiac surgery. The desired outcome is "bridge-to-recovery" in most cases. There is no universally agreed protocol, and given the associated costs and complications rates, the decisions as of when and when not to institute VA ECMO are largely empirical. Methods: A retrospective review of the ECMO database at the Scottish Pediatric Cardiac Services (SPCS) was undertaken...
January 2018: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/29429200/-outcome-of-pediatric-extracorporeal-membrane-oxygenation-in-a-single-center
#14
Q Bao, X Y Hong, Y Y Liu, X J Zhang, H T Gao, Z C Feng
Objective: To investigate the application and outcome of pediatric extracorporeal membrane oxygenation (ECMO) in a single center. Methods: The clinical data of 52 pediatric patients with cardiopulmonary failure received ECMO support in Bayi Children's Hospital Affiliated to General Hospital of Beijing Military Command of PLA were collected from January 2012 to October 2016. All patients were divided into two stages by time. January 2012 to December 2014 was stage one. January 2015 to October 2016 was stage two...
February 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29373368/adenosine-2a-receptor-activation-attenuates-ischemia-reperfusion-injury-during-extracorporeal-cardiopulmonary-resuscitation
#15
James H Mehaffey, Dustin Money, Eric J Charles, Sarah Schubert, Angela Fernandez Piñeros, Di Wu, Sai Vineela Bontha, Robert Hawkins, Nicholas R Teman, Victor E Laubach, Valeria R Mas, Curtis G Tribble, Daniel G Maluf, Ashish K Sharma, Zequan Yang, Irving L Kron, Mark E Roeser
OBJECTIVE: We tested the hypothesis that systemic administration of an A2AR agonist will reduce multiorgan IRI in a porcine model of ECPR. SUMMARY BACKGROUND DATA: Advances in ECPR have decreased mortality after cardiac arrest; however, subsequent IRI contributes to late multisystem organ failure. Attenuation of IRI has been reported with the use of an A2AR agonist. METHODS: Adult swine underwent 20 minutes of circulatory arrest, induced by ventricular fibrillation, followed by 6 hours of reperfusion with ECPR...
January 25, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29303029/the-use-of-ecmo-for-the-treatment-of-refractory-cardiac-arrest-or-postarrest-cardiogenic-shock-following-in-hospital-cardiac-arrest-a-10-year-experience
#16
Meshe Chonde, Penny Sappington, Robert Kormos, Andrew Althouse, Arthur Boujoukos
OBJECTIVES: Extracorporeal membrane oxygenation (ECMO) has been increasingly used in the treatment of refractory cardiac arrest (extracorporeal cardiopulmonary resuscitation [ECPR]) and postarrest cardiogenic shock (PACS). Our primary objective was to determine the 1-year survival of patients who were treated with ECMO for PACS or in ECPR. METHODS: We conducted a retrospective analysis of hospitalized patients in a tertiary care facility who underwent treatment with ECMO for ECPR or PACS...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29249614/extracorporeal-cardiopulmonary-resuscitation-for-refractory-out-of-hospital-cardiac-arrest-the-state-of-the-evidence-and-framework-for-application
#17
REVIEW
Brian Grunau, Laura Hornby, Rohit K Singal, Jim Christenson, Ivan Ortega-Deballon, Sam D Shemie, Jamil Bashir, Steve C Brooks, Clifton W Callaway, Elena Guadagno, Dave Nagpal
Out-of-hospital cardiac arrest (OHCA) affects 134 per 100,000 citizens annually. Extracorporeal cardiopulmonary resuscitation (ECPR), providing mechanical circulatory support, may improve the likelihood of survival among those with refractory OHCA. Compared with in-hospital ECPR candidates, those in the out-of-hospital setting tend to be sudden unexpected arrests in younger and healthier patients. The aims of this review were to summarize, and identify the limitations of, the evidence evaluating ECPR for OHCA, and to provide an approach for ECPR program application...
February 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29171213/extracorporeal-cardiopulmonary-resuscitation-with-therapeutic-hypothermia-for-prolonged-refractory-in-hospital-cardiac-arrest
#18
Yun Seok Kim, Yong Jik Lee, Ki Bum Won, Jeong Won Kim, Sang Cjeol Lee, Chang Ryul Park, Jong Pil Jung, Wookjin Choi
BACKGROUND AND OBJECTIVES: We identified the impact of extracorporeal cardiopulmonary resuscitation (ECPR) followed by therapeutic hypothermia on survival and neurologic outcome in patients with prolonged refractory in-hospital cardiac arrest (IHCA). METHODS: We enrolled 16 adult patients who underwent ECPR followed by therapeutic hypothermia between July 2011 and December 2015, for IHCA. Survival at discharge and cerebral performance category (CPC) scale were evaluated...
November 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/29129499/d-dimer-predicts-bleeding-complication-in-out-of-hospital-cardiac-arrest-resuscitated-with-extracorporeal-membrane-oxygenation
#19
Takayuki Otani, Hirotaka Sawano, Tomoaki Natsukawa, Reiko Matsuoka, Tetsufumi Nakashima, Motonori Takahagi, Yasuyuki Hayashi
PURPOSE: In out-of-hospital cardiac arrest (OHCA) patients resuscitated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO), known as extracorporeal cardiopulmonary resuscitation (ECPR), bleeding is a common complication. The purpose of this study was to assess the risk factors for bleeding complications in ECPR patients. METHODS: We retrospectively analyzed the data for OHCA patients admitted to our hospital and resuscitated with ECPR between October 2009 and December 2016...
November 8, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29084037/extracorporeal-cardiopulmonary-resuscitation-among-patients-with-structurally-normal-hearts
#20
Stephanie J Conrad, Brian C Bridges, Yuvraj Kalra, John B Pietsch, Andrew H Smith
Extracorporeal cardiopulmonary resuscitation (eCPR) has been well described as a rescue therapy in refractory cardiac arrest among patients with congenital heart disease. The purpose of this retrospective analysis of data from the Extracorporeal Life Support Organization was to evaluate outcomes of eCPR in patients with structurally normal hearts and to identify risk factors that may contribute to mortality. During the study period, 1,431 patients met inclusion criteria. Median age was 16 years. Overall survival to hospital discharge was 32%...
November 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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