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https://www.readbyqxmd.com/read/29793021/phosphoinositide-3-kinase-p110%C3%AE-negatively-regulates-thrombopoietin-mediated-platelet-activation-and-thrombus-formation
#1
T A Blair, S F Moore, T G Walsh, J L Hutchinson, T N Durrant, K E Anderson, A W Poole, I Hers
Phosphoinositide 3-kinase (PI3K) plays an important role in platelet function and contributes to platelet hyperreactivity induced by elevated levels of circulating peptide hormones, including thrombopoietin (TPO). Previous work established an important role for the PI3K isoform; p110β in platelet function, however the role of p110α is still largely unexplored. Here we sought to investigate the role of p110α in TPO-mediated hyperactivity by using a conditional p110α knockout (KO) murine model in conjunction with platelet functional assays...
May 21, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29793013/may-thurner-syndrome-presenting-as-acute-unexplained-dvt
#2
Zulfiqar Qutrio Baloch, Muhammad Hussain, Muhammad Ayyaz, Nishant Dagli, Shabber Agha Abbas
May-Thurner syndrome (MTS) is a rare cause of deep venous thrombosis (DVT) and occurs due to an anatomic anomaly which produces chronic compression of the left common iliac vein by the overlying right common iliac artery when it passes between the right common iliac artery and the spine. Prolonged compression on the vein potentiates thrombus formation by impairing the intima and by leading to the development of membranes within the lumen that may decrease and/or block venous flow. In this case presentation, we elaborate upon a case of a 43-year-old woman who presented with worsening left leg swelling and pain...
May 21, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29792748/portal-vein-thrombosis-imaging-the-spectrum-of-disease-with-an-emphasis-on-mri-features
#3
Reena C Jha, Satinderpal Singh Khera, Amit Dinesh Kalaria
OBJECTIVE: The purpose of this article is to review the classic and uncommon imaging findings of portal vein thrombosis (PVT) (acute, chronic, congenital, and septic thrombus) as visualized on multiple modalities, with an emphasis on MRI findings. Additional aims are to understand the imaging of obliterative portal venopathy and its clinical significance, appreciate morphologic changes of the biliary system that may accompany PVT, and recognize changes in liver enhancement patterns seen with PVT related to the hepatic arterial buffer response...
May 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29791972/laparoscopic-radical-nephrectomy-for-a-right-renal-tumor-with-renal-vein-tumor-thrombus-in-a-patient-with-situs-inversus-totalis
#4
Jun Ito, Yasuhiro Kaiho, Hiromichi Iwamura, Go Anan, Makoto Sato
Situs inversus totalis (SIT) is a rare congenital anomaly characterized by complete inversion of the thoracic and abdominal organs. Many intra-abdominal and vessel anomalies have been reported in association with SIT. However, there have been no reports on the use of laparoscopic radical nephrectomy with thrombectomy for renal vein thrombus, which is considered as a safe and feasible procedure, in patients with SIT. We herein present the case of an 80-year-old man with SIT who was preoperatively diagnosed with a right renal tumor and renal vein tumor thrombus...
May 23, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29790225/can-cardiovascular-mri-be-used-to-more-definitively-characterize-cardiac-masses-initially-identified-using-echocardiography
#5
Vikas K Rathi, Anna T Czajka, Diane V Thompson, Mark Doyle, Tarun Tewatia, June Yamrozik, Ronald B Williams, Robert W W Biederman
In diagnosing cardiac and paracardiac masses, cardiac MRI (CMR) has gained acceptance as the gold standard. CMR has been observed to be superior to echocardiography in characterizing soft-tissue structures and, specifically, in classifying cardiac masses. The aim of our study was to evaluate the association between mortality and cardiac or paracardiac masses initially identified by echocardiography (ECHO) and confirmed by CMR. Between January 2002 and August 2007, a total of 158 patients underwent both ECHO and CMR for the evaluation of cardiac masses that were equivocal or undefined by ECHO...
May 2018: Echocardiography
https://www.readbyqxmd.com/read/29790081/transplant-renal-vein-thrombosis-in-a-recipient-with-aberrant-venous-anatomy
#6
Lyndsey Thiessen, Sarah MacDonell, Chris Wall, Preman Jacob, Ahmed Shoker, Michael A J Moser
Renal vein thrombosis in a transplanted kidney is an uncommon but critical complication that can result in graft loss if management is delayed. A 31-year-old male with known atresia of the inferior vena cava who received a deceased donor renal transplant 7 years previously presented to hospital with severe graft site pain and a week of nausea, vomiting, and chills. Serum creatinine was markedly elevated from baseline. Sonographic examination revealed external iliac vein thrombosis with extension of the thrombus into the transplant renal vein...
May 22, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29789918/recent-experience-and-follow-up-after-surgical-closure-of-secundum-atrial-septal-defect-in-120-children
#7
Geoffroy de Beco, Natasha Mambour, Christophe Vô, Laetitia Vanhoutte, Stéphane Moniotte, Alain Poncelet, Thierry Sluysmans
While percutaneous catheter closure proves an effective treatment for secundum atrial septal defect (ASD2), some child patients require surgical closure. We assessed the risks associated with isolated surgical ASD2 closure by reviewing the outcomes of 120 children operated on between 1999 and 2011 (mean age 4.6 ± 3.9 years, mean weight 17 ± 12 kg). Direct sutures were performed in 4% and patch closures in 96%. The mean cardiopulmonary bypass duration was 38 ± 14 min, aortic cross-clamp time 19 ± 9 min, intensive care unit length of stay 1...
May 22, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29788894/rotational-atherectomy-in-acute-stemi-with-heavily-calcified-culprit-lesion-is-a-rule-breaking-solution
#8
Mohammady Shahin
Calcified coronary lesions represents technical challenges and are associated with a high frequency of restenosis and target lesion revascularization.1 Rotational atherectomy has been shown to increase procedural success in severely calcified lesions, facilitate stent delivery in undilatable lesions and ensure complete stent expansion(2,3). However rotational atherectomy in ST-elevation myocardial infarction (STEMI) is traditionally avoided given the concern for slow or no reflow(4) and considerded as a contraindication by its manufacturer (Rotablator, Boston Scientific) in a lesion with a visible thrombus...
May 22, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29788818/a-systematic-review-on-the-use-of-deep-venous-stenting-for-acute-venous-thrombosis-of-the-lower-limb
#9
Mohamed Ah Taha, Andrew Busuttil, Roshan Bootun, Alun H Davies
Objectives The aim is to evaluate venous stent patency, the development of post-thrombotic syndrome, recurrence, quality of life and the optimal post-procedural anticoagulation regimen in the treatment of iliofemoral deep venous thrombosis. Method and results EMBASE and Medline databases were interrogated to identify studies in which acute deep venous thrombosis patients were stented. Twenty-seven studies and 542 patients were identified. Primary, assisted primary and secondary patency rates 12 months after stent placement ranged from 74 to 95, 90 to 95 and 84 to 100%, respectively...
January 1, 2018: Phlebology
https://www.readbyqxmd.com/read/29788143/pedunculated-aortic-thrombus-propagating-from-the-right-coronary-artery-in-a-patient-with-iga-nephropathy
#10
Jacques Scherman, Natercia da Silva, Adriaan Myburgh, Timothy Pennel
No abstract text is available yet for this article.
May 16, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29787534/a-metal-organic-framework-reduces-thrombus-formation-and-platelet-aggregation-ex-vivo
#11
Teryn R Roberts, Megan J Neufeld, Michael A Meledeo, Andrew P Cap, Leopoldo C Cancio, Melissa M Reynolds, Andriy I Batchinsky
BACKGROUND: Management of hemostasis is a key challenge during extracorporeal life support (ECLS). Metal organic frameworks are being investigated for use as nitric oxide (NO) catalysts for incorporation into ECLS circuitry to prevent thrombosis at the blood-biomaterial interface. A specific metal organic framework, CuBTTri, has been shown to accelerate NO-release from bioavailable donors like S-nitrosoglutathione (GSNO). We hypothesized that CuBTTri would reduce thrombus formation in whole blood (WB) and inhibit platelet aggregation...
May 21, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29787368/contemporary-surgical-outcomes-of-venous-tumour-thrombectomy-managed-with-intraoperative-doppler-ultrasound-for-kidney-cancer
#12
Deepak K Pruthi, Hanzhang Wang, Arpan Satsangi, Miguel Cajipe, Kevan Iffrig, Georges M Haidar, Taylor Hicks, Edward Y Sako, Michael A Liss, Wasim H Chowdhury, Ronald Rodriguez, Dharam Kaushik
INTRODUCTION: Radical nephrectomy (RN) with venous tumour thrombectomy (VTT) carries a significant morbidity and mortality risk. Examination of a contemporary single-institution series permits the development of a management algorithm and an audit its results. We report outcomes following the use of intraoperative colour Doppler ultrasound and our surgical pathway. METHODS: We retrospectively reviewed the records of all patients who underwent RN with VTT for kidney cancer between January 1, 2013 and October 1, 2016...
May 14, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29785758/undifferentiated-embryonal-sarcoma-of-liver-in-an-adult-with-spontaneous-rupture-and-tumour-thrombus-in-the-right-atrium
#13
Narendra Pandit, Lokesh S Jaiswal, Vijay Shrestha, Lalijan Awale, Shailesh Adhikary
No abstract text is available yet for this article.
May 22, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29785381/primary-renal-large-b-cell-lymphoma-imitating-invasive-renal-cell-carcinoma-with-inferior-vena-cava-tumor-thrombus
#14
Nnenaya Q Agochukwu, Amichai Kilchevsky, David Hesse
No abstract text is available yet for this article.
May 2018: Urology Case Reports
https://www.readbyqxmd.com/read/29784681/use-of-intracardiac-echocardiography-in-interventional-cardiology-working-with-the-anatomy-rather-than-fighting-it
#15
REVIEW
Andres Enriquez, Luis C Saenz, Raphael Rosso, Frank E Silvestry, David Callans, Francis E Marchlinski, Fermin Garcia
The indications for catheter-based structural and electrophysiological procedures have recently expanded to more complex scenarios, in which an accurate definition of the variable individual cardiac anatomy is key to obtain optimal results. Intracardiac echocardiography (ICE) is a unique imaging modality able to provide high-resolution real-time visualization of cardiac structures, continuous monitoring of catheter location within the heart, and early recognition of procedural complications, such as pericardial effusion or thrombus formation...
May 22, 2018: Circulation
https://www.readbyqxmd.com/read/29784642/identification-of-key-lipids-critical-for-platelet-activation-by-comprehensive-analysis-of-the-platelet-lipidome
#16
Bing Peng, Sascha Geue, Cristina Coman, Patrick Münzer, Dominik Kopczynski, Canan Has, Nils Hoffmann, Mailin-Christin Manke, Florian Lang, Albert Sickmann, Meinrad Gawaz, Oliver Borst, Robert Ahrends
Platelet integrity and function critically depend on lipid composition. However, the lipid inventory in platelets was hitherto not quantified. Here, we examined the lipidome of murine platelets using lipid-category tailored protocols on a quantitative lipidomics platform. We could show that the platelet lipidome comprises almost 400 lipid species and covers a concentration range of seven orders of magnitude. A systematic comparison of the lipidomics network in resting and activated murine platelets, validated in human platelets, revealed that less than 20% of the platelet lipidome is changed upon activation, involving mainly lipids containing arachidonic acid...
May 21, 2018: Blood
https://www.readbyqxmd.com/read/29784641/intrinsic-apoptosis-circumvents-the-functional-decline-of-circulating-platelets-but-does-not-cause-the-storage-lesion
#17
Irina Pleines, Marion Lebois, Pradnya Gangatirkar, Amanda E Au, Rachael M Lane, Katya J Henley, Maria Kauppi, Jason Corbin, Ping Cannon, Jonathan Bernardini, Imala Alwis, Kate E Jarman, Sarah Ellis, Donald Metcalf, Shaun P Jackson, Simone M Schoenwaelder, Benjamin T Kile, Emma C Josefsson
The circulating life span of blood platelets is regulated by the pro-survival protein BCL-XL. It restrains the activity of BAK and BAX, the essential pro-death mediators of intrinsic apoptosis. Disabling the platelet intrinsic apoptotic pathway in mice by deleting BAK and BAX results in a doubling of platelet life span and concomitant thrombocytosis. Apoptotic platelets expose phosphatidylserine (PS) via a mechanism that is distinct from that driven by classical agonists. Whether there is any role for apoptotic PS in platelet function in vivo, however, is unclear...
May 21, 2018: Blood
https://www.readbyqxmd.com/read/29784632/the-solitaire-device-on-the-cards-for-retrieval-of-recalcitrant-thrombus-in-acute-coronary-syndrome
#18
Deanna Z L Khoo, Jin Hyun Lee, Timothy J Watson, Paul J L Ong
No abstract text is available yet for this article.
May 21, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29784124/caval-thrombus-management-the-data-where-we-are-and-how-it-is-done
#19
Brittany Harrison, Frank Hao, Nii Koney, Justin McWilliams, John M Moriarty
Thromboses of the superior and inferior vena cava, either isolated or associated with distal deep venous thrombosis, are uncommon, but confer potentially serious morbidity and mortality. Incidence is increasing, especially with the prominence of intravascular devices. The range of treatment options is also expanding to include medical management, surgery, and endovascular techniques which are now frequently considered first line therapy due to lower reintervention rates and decreased periprocedural morbidity...
June 2018: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/29784123/endovascular-interventions-for-venous-disease
#20
REVIEW
Paul O'Connor, Robert Lookstein
Venous thromboembolism, including deep vein thrombosis and pulmonary embolism, occur in up to 900,000 people per year in the United States. Current first-line therapy consists of systemic anticoagulation with a goal to prevent additional thrombus formation. Treatment with anticoagulation alone provides less than satisfactory results with some studies showing propagation of thrombus in almost 40% of cases. Current first-line therapy does not include active removal of thrombus and does little to alleviate acute symptoms and the damaging inflammatory response that may result in postthrombotic syndrome...
June 2018: Techniques in Vascular and Interventional Radiology
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