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https://www.readbyqxmd.com/read/29356341/cryopreserved-neonatal-hepatocytes-may-be-a-source-for-transplantation-evaluation-of-functionality-towards-clinical-use
#1
Charlotte A Lee, Anil Dhawan, Valeria Iansante, Sharon Lehec, Shirin Elizabeth Khorsandi, Celine Filippi, Simon Walker, Raquel Fernandez-Dacosta, Nigel Heaton, Sanjay Bansal, Ragai R Mitry, Emer Fitzpatrick
Neonatal livers are a potential source of good quality hepatocytes for clinical transplantation. We compared viability and function of neonatal and adult hepatocytes, and report their clinical use both intra-portally and in alginate microbeads. Following isolation from donor livers, hepatocyte function was assessed using albumin, alpha-1 antitrypsin and factor VII. Metabolic function was investigated by measuring resorufin conjugation, ammonia metabolism, UGT enzyme activity and cytochrome P450 function following induction...
January 21, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29355112/in-vitro-measurement-of-platelet-adhesion-to-intact-endothelial-cells-under-low-shear-conditions
#2
Yuki Ogawa, Takuma Nakahara, Yuma Nishida, Chihiro Kobayashi, Takamichi Hirata, Hideaki Nagano, Suguru Shiratori, Kenjiro Shimano
BACKGROUND: Prediction of thrombus formation at intact arterial walls under low shear flow conditions is clinically important particularly for better prognoses of embolization in cerebral aneurysms. Although a new mathematical model for this purpose is necessary, little quantitative information has been known about platelet adhesion to intact endothelial cells. OBJECTIVE: The objective of this study is to measure the number of platelets adhering to intact endothelial cells with a focus upon the influence of the shear rate...
January 16, 2018: Biorheology
https://www.readbyqxmd.com/read/29354797/correlates-of-plasma-and-platelet-tissue-factor-pathway-inhibitor-factor-v-and-protein-s
#3
Paul E R Ellery, Ida Hilden, Ken Sejling, Mette Loftager, Nicholas D Martinez, Susan A Maroney, Alan E Mast
Background: Plasma Tissue Factor Pathway Inhibitor (TFPI) circulates bound to factor V (fV) and Protein S (PS). Estrogen therapy decreases plasma TFPI and PS. TFPI, fV, and PS circulate within platelets, and are released upon activation to modulate thrombus formation. Objective: Identify factors affecting the concentrations of plasma and platelet TFPI, fV, and PS. Methods: Blood samples were obtained from 435 healthy individuals. Plasma total TFPI, TFPIɑ, fV, and PS, and platelet TFPI, fV, and PS were quantified...
January 2018: Research and Practice in Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29353683/diagnosing-upper-extremity-deep-vein-thrombosis-with-non-contrast-enhanced-magnetic-resonance-direct-thrombus-imaging-a-pilot-study
#4
C E A Dronkers, F A Klok, G R van Haren, J Gleditsch, E Westerlund, M V Huisman, L J M Kroft
Diagnosing upper extremity deep vein thrombosis (UEDVT) can be challenging. Compression ultrasonography is often inconclusive because of overlying anatomic structures that hamper compressing veins. Contrast venography is invasive and has a risk of contrast allergy. Magnetic Resonance Direct Thrombus Imaging (MRDTI) and Three Dimensional Turbo Spin-echo Spectral Attenuated Inversion Recovery (3D TSE-SPAIR) are both non-contrast-enhanced Magnetic Resonance Imaging (MRI) sequences that can visualize a thrombus directly by the visualization of methemoglobin, which is formed in a fresh blood clot...
January 10, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29352701/bailout-surgical-explantation-of-a-transcatheter-valve-in-valve-for-subacute-thrombosis-when-there-is-no-time-for-anticoagulation-case-report-and-literature-review
#5
Francesco Notaristefano, Matteo Rocco Reccia, Salvatore Notaristefano, Roberto Annunziata, Rocco Sclafani, Giuseppe Ambrosio, Claudio Cavallini
Trancatheter heart valve (THV) thrombosis is effectively treated with anticoagulation but alternative therapies are required when a faster gradient reduction is needed. Open heart surgery has been rarely performed due to the high perioperative mortality and only five cases have been described so far. Here we describe a case of emergent surgical explantation for THV thrombosis after a valve-in-valve. A 67years old man underwent transcatheter aortic valve implantation for a failed surgical bioprosthesis Epic 21mm (St...
December 13, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29352651/catheter-injected-bone-marrow-mesenchymal-stem-cells-induce-efficacious-occlusion-of-arteriovenous-nidus-in-a-swine-model
#6
Joseph Touma, Jianping Dai, Andre Gaston, Marianne Gervais, Eric Allaire
OBJECTIVES: Arteriovenous malformations (AVMs) are complex vascular lesions. Surgical excision is the treatment of choice, but is often not achievable. Embolo-sclerotherapy alone is associated with high recurrence rates. This study tested the hypothesis that seeding hydrogel conditioned bone marrow derived mesenchymatous stem cells (BM-MSCs) in an AVM nidus model induces solid microvascular occlusion through endoluminal tissue growth. METHODS: AVMs were modelled as arteriovenous microvascular nidus, using swine rete mirabile, a plexiform intracranial structure composed of arterial microvessels that extensively anastomose...
January 15, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29350605/in-situ-administration-of-abciximab-for-thrombus-resolution-during-intracranial-bypass-surgery-case-report
#7
Ian A Buchanan, Brian Lee, Arun P Amar, Steven L Giannotta
Abciximab is a glycoprotein IIb/IIIa receptor antagonist that functions to prevent platelet aggregation, thus reducing thrombus initiation and propagation. It has been widely used during percutaneous endovascular interventions, such as aneurysm coil embolization, angioplasty, atherectomy, and stent placement, as both a preventative and a salvage therapy. The use of abciximab in cardiac and neurosurgical procedures has been associated with a reduced incidence of ischemic complications and a decreased need for repeated intervention...
January 19, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29350390/dual-antiplatelet-therapy-is-safe-and-efficient-after-left-atrial-appendage-closure
#8
Jakub Maksym, Tomasz Mazurek, Janusz Kochman, Marek Grygier, Agnieszka Kapłon-Cieślicka, Michał Marchel, Piotr Lodziński, Radosław Piątkowski, Radosław Wilimski, Paweł Czub, Anna Fojt, Natalia Karolczak, Piotr Hendzel, Grzegorz Opolski
BACKGROUND: Despite of PROTECT AF trial results many patients undergoing left atrial appendage closure (LAAC) have unconditional contraindications to warfarin. AIM: We sought to investigate whether double antiplatelet therapy (DAPT) is safe in patients after LAAC. METHODS: 44 (22 males, mean age 74±7.8) consecutive patients with non-valvular atrial fibrillation (NVAF) underwent LAAC procedure using Watchman device followed by DAPT (75 mg Aspirin and 75 mg Clopidogrel)...
January 19, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29350098/commentary-to-18f-gp1-a-novel-pet-tracer-designed-for-high-sensitivity-low-background-detection-of-thrombi-imaging-activated-platelets-in-clots-are-we-getting-there
#9
Andrew W Stephens, Norman Koglin, Ludger M Dinkelborg
Thrombus formation can lead to heart attacks, stroke and pulmonary embolism, which are major causes of mortality. Current standard diagnostic imaging methods detect anatomic abnormalities such as vascular flow impairment but have limitations. By using a targeted molecular imaging approach critical components of a pathology can be selectively visualized and exploited for an improved diagnosis and patient management. The GPIIb/IIIa receptor is abundantly and specifically exposed on activated platelets and is the key receptor in thrombus formation...
January 2018: Molecular Imaging
https://www.readbyqxmd.com/read/29349786/acute-lion-s-mane-jellyfish-cyanea-capillata-cnideria-scyphozoa-exposure-to-atlantic-salmon-salmo-salar-l
#10
M D Powell, Å Åtland, T Dale
Jellyfish-induced gill pathology relies upon occasional diagnostic observations yet the extent and impact of jellyfish blooms on aquaculture may be significant. Idiopathic gill lesions are often observed in apparently healthy fish. This study exposed Atlantic salmon (Salmo salar L.) smolts to macerated Cyanea capillata at 2.5 and 5 g/L for 2 hr under controlled laboratory conditions. Blood chemistry and gill histopathology were examined over a subsequent 4-week period. Fish showed an acute response to the presence of jellyfish, including characteristic external "whiplash" discoloration of the skin and acute increases in blood electrolytes and CO2 concentration; however, these were resolved within 4 days after exposure...
January 18, 2018: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29349415/a-track-made-by-organized-thrombus-after-catheter-fragment-removal-mimicking-a-remnant-catheter-in-the%C3%A2-popliteal-artery
#11
Tae-Hoon Kim, Michael Azrin, Juyong Lee
No abstract text is available yet for this article.
September 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29349404/external-jugular-vein-thrombosis-secondary-to-deep-tissue-neck%C3%A2-massage
#12
Sneha Raju, John Byrne
An 85-year-old man presented with an acute asymptomatic lateral neck mass in the context of deep tissue neck massages during the past year. He was referred to vascular surgery after an ultrasound examination of the neck revealed a thrombus in the external jugular vein. His past medical history and comorbidities were noncontributory. A multidisciplinary team of vascular surgeons and hematologists did not recommend any anticoagulation, given that the patient did not have any risk factors for thrombosis as well as normal D-dimer levels...
September 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29349395/delayed-migration-of-a-thrombosed-aortic-endograft-within-a-thrombosed-aneurysm-sac-resulting-in-continued-sac-expansion-and-rupture
#13
Edvard Skripochnik, Nicos Labropoulos, Shang A Loh
We present the case of delayed migration of a thrombosed aortic endograft within a thrombosed aneurysm sac that expanded and ruptured. Dilation of the aortic neck likely led to endograft migration and exposure of the occluded endograft and aneurysm sac to systemic pressure. Although no endoleak was identified, a key finding on ultrasound showed mobility of the sac thrombus. This may be an indicator of flow within the sac that may predict potential for rupture. Despite thrombosis of the aortic sac and endograft, the risk of rupture still lingers, and thus continued surveillance of occluded endografts may be prudent...
September 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29349391/inguinal-pain-and-fullness-due-to-an-intravascular-leiomyoma-in-the-external-iliac-vein
#14
Edvard Skripochnik, Lisa Marie Terrana, Nicos Labropoulos, Melissa Henretta, Todd Griffin, Shang A Loh
Intravascular leiomyomatosis (IVL) is a benign smooth muscle tumor that evolves from the pelvic veins and can spread to the central veins and heart. Cardiac involvement is the most commonly reported presentation. Initial diagnosis is difficult, and IVL is commonly misdiagnosed as thrombus or atrial myxoma. Appropriate imaging and a high clinical suspicion are required for accurate diagnosis. We report a rare case of IVL in the external iliac vein that recurred 4 years after hysterectomy. Only four cases have been reported in the literature to involve the external iliac vein as it has no direct connection to pelvic venous drainage...
June 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29348012/coronary-embolus-an-underappreciated-cause-of-acute-coronary-syndromes
#15
REVIEW
Claire E Raphael, John A Heit, Guy S Reeder, Melanie C Bois, Joseph J Maleszewski, R Thomas Tilbury, David R Holmes
Coronary embolism is the underlying cause of 3% of acute coronary syndromes but is often not considered in the differential of acute coronary syndromes. It should be suspected in the case of high thrombus burden despite a relatively normal underlying vessel or recurrent coronary thrombus. Coronary embolism may be direct (from the aortic valve or left atrial appendage), paroxysmal (from the venous circulation through a patent foramen ovale), or iatrogenic (following cardiac intervention). Investigations include transesophageal echocardiography to assess the left atrial appendage and atrial septum and continuous electrocardiographic monitoring to assess for paroxysmal atrial fibrillation...
January 22, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29346710/an-extensive-caseous-calcification-of-the-mitral-annulus-complicated-with-severe-mitral-regurgitation
#16
Alper Karakus, Hakan Tibilli, Ibrahim H Inanc, Hakan Tasolar, Serdar Turkmen, Erdal Akturk
Caseous calcification of the mitral annulus (CCMA) is considered a rare variant of mitral annular calcification (MAC) due to caseous transformation of the inner material and prevalence of CCMA, about 0.63% of all MAC cases and 0.06%-0.07% of the population. The precise pathophysiology of CCMA is still unknown. It is a chronic degenerative disorder common in the elderly, particularly in women. Caseous calcification of the mitral annulus (CCMA) is a soft peri-annular extensive calcification, resembling cardiac tumors, abscesses, vegetation, or calcified thrombus, which is composed of an admixture of calcium, fatty acids, and cholesterol with a toothpaste-like texture...
January 18, 2018: Echocardiography
https://www.readbyqxmd.com/read/29346575/abacavir-induces-arterial-thrombosis-in-a-murine-model
#17
Victor Collado-Diaz, Isabel Andujar, Ainhoa Sanchez-Lopez, Samuel Orden, María Amparo Blanch-Ruiz, María Angeles Martinez-Cuesta, Ana Blas-García, Juan V Esplugues, Ángeles Álvarez
Objective and methods: The effects of abacavir were evaluated in a validated model of arterial thrombosis. The role of ATP-P2X7-receptors and the actions of two vascular-damaging agents (diclofenac or rofecoxib) and other NRTIs were also analysed. Results: Abacavir dose-dependently promoted thrombus formation. This effect was reversed by a P2X7-receptor antagonist and was non-existent in P2X7 KO mice. The effects of abacavir were similar to those of diclofenac and rofecoxib...
January 16, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29344717/multiple-enlarged-aneurysms-in-primary-racemose-hemangioma-of-the-bronchial-artery-successful-prophylactic-transcatheter-arterial-embolization-using-n-butyl-2-cyanoacrylate-and-coils
#18
Atsushi Saiga, Toshihiko Sugiura, Takashi Higashide, Satoshi Tsuchiya, Akira Nishiyama, Yoshihiro Kubota, Takuro Horikoshi, Takashi Uno
An asymptomatic 48-year-old man presented with multiple aneurysms in a primary racemose hemangioma of the right bronchial artery. Bronchial arteriography revealed a tortuous artery with four fusiform aneurysms of varying sizes and aneurysmal dilatation with marked thrombus formation in the long segment of the distal portion. Because the tip of catheter could not pass beyond the aneurysmal dilatation, we performed balloon-occluded embolization using a mixture of N-butyl-2-cyanoacrylate (NBCA) and iodized oil...
January 17, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29344582/factor-xiii-in-plasma-but-not-in-platelets-mediates-red-blood-cell-retention-in-clots-and-venous-thrombus-size-in-mice
#19
Sravya Kattula, James R Byrnes, Sara M Martin, Lori A Holle, Brian C Cooley, Matthew J Flick, Alisa S Wolberg
The transglutaminase factor XIII (FXIII) stabilizes clots against mechanical and biochemical disruption and is essential for hemostasis. In vitro and in vivo models of venous thrombosis demonstrate that FXIII mediates clot size by promoting red blood cell (RBC) retention. However, the key source of FXIII and whether FXIII activity can be reduced to suppress thrombosis without imposing deleterious hemostatic consequences are 2 critical unresolved questions. FXIII is present in multiple compartments, including plasma (FXIIIplasma) as a heterotetramer of A2 and B2 subunits and platelets (FXIIIplt) as an A2 homodimer...
January 9, 2018: Blood Advances
https://www.readbyqxmd.com/read/29340161/direct-ice-imaging-from-inside-the-left-atrial-appendage-during-ablation-of-persistent-atrial-fibrillation
#20
Gabriel Cismaru, Mihai Puiu, Radu Rosu, Lucian Muresan, Gabriel Gusetu, Dana Pop, Dumitru Zdrenghea
We present the case of a 59-year-old patient with persistent atrial fibrillation, referred for atrial fibrillation ablation. The procedure was performed with the help of NAVX 3D mapping system (Saint Jude Medical) and iLAB Ultra ICE Plus ultrasound imaging catheter (Boston Scientific). The catheter permits cross-sectional images perpendicular to catheter's long axis. From inside left atrial appendage (LAA) looks trabeculated, due to pectinate muscles running parallel to each other. The presence of a thrombus was excluded from the appendage...
January 2018: Oxford Medical Case Reports
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