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Distraction osteogenesis

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https://www.readbyqxmd.com/read/28938392/segmental-bone-loss-reconstruction-using-ring-fixation
#1
Stephen M Quinnan
Ring fixation is a powerful tool in the treatment of bone defects. The ability to create high-quality, biologically normal new bone of even massive proportions using distraction osteogenesis is a major reason for its success. In addition, ring fixation provides the ability to limit the risk of deep infection, improves flexibility in limb length control and alignment, and increases soft tissue coverage options. The drawbacks of ring fixation include long frame times, pin problems, risk of joint contractures, and difficult usage in areas with a large soft tissue envelope such as the thigh...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28938387/critical-sized-bone-defects-sequence-and-planning
#2
Paul Toogood, Theodore Miclau
Bone defects associated with open fractures require a careful approach and planning. At initial presentation, an emergent irrigation and debridement is required. Immediate definitive fixation is frequently safe, with the exception of those injuries that normally require staged management or very severe type IIIB and IIIC injuries. Traumatic wounds that can be approximated primarily should be closed at the time of initial presentation. Wounds that cannot be closed should have a negative pressure wound therapy dressing applied...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28938321/the-pierre-robin-mandible-is-hypoplastic-and-morphologically-abnormal
#3
Elizabeth G Zellner, Russell R Reid, Derek M Steinbacher
BACKGROUND: For Pierre Robin sequence (PRS) patients, there is incomplete characterization of 3D differences and effects of mandibular distraction osteogenesis (MDO) on the mandible compared to normal controls. METHODS: PRS infants who underwent MDO at 2 craniofacial referral centerals with pre- and postoperative computed tomography (CT) scans were identified. A group of age-matched control patients with CTs were identified in the PACS database. Demographic and perioperative data were recorded...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28938316/frontal-hyperostosis-in-the-patients-of-craniosynostosis-after-cranial-distraction-osteogenesis
#4
Koji Kawamoto, Cheng Chun Wu, Keisuke Imai
BACKGROUND: Conventional fronto-orbital advancement and distraction osteogenesis (DOG) have been used to treat craniosynostosis, both of which are considered effective. During the authors' practice, a phenomenon of frontal hyperostosis has been observed in the patients of craniosynostosis after DOG, which has yet to be reported in the literature. The purpose of this study is trying to identify the factors related to the phenomenon. MATERIALS AND METHODS: From 1997 to 2010, all patients of craniosynostosis undergoing DOG were reviewed...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28938286/optimizing-bone-defect-reconstruction-balanced-cable-transport-with-circular-external-fixation
#5
Stephen Matthew Quinnan, Charles Lawrie
Distraction osteogenesis has proven effective in the management of tibial bone loss from severe trauma and infection. Unfortunately, pain and scarring from wires and half pins dragging through the skin and the required prolonged time in the external fixator make treatment difficult. Cable bone transport has been shown to improve cosmesis and decrease pain during transport. However, the published methods have limitations in that they have poor control of transport segment alignment, do not allow for lengthening of the limb, and do not permit weight bearing during the treatment process...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28930929/avoidance-of-tracheostomy-using-mandibular-distraction-in-an-infant-with-severe-condylar-dysplasia-and-airway-obstruction
#6
Anthony J Archual, Jonathan S Black
Craniofacial microsomia (CFM) is a common craniofacial anomaly characterized by asymmetric malformation of the mandible, ear, and other structures including the upper airway. The degree of mandibular hypoplasia is classified using a scheme developed by Pruzansky and modified by Kaban. Severe condylar dysplasia is the hallmark of Pruzansky-Kaban types IIB and III. Distraction osteogenesis has emerged as a treatment modality for mandibular hypoplasia in this setting for the treatment of asymmetry and airway obstruction...
September 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28930778/radioprotection-with-amifostine-enhances-bone-strength-and-regeneration-and-bony-union-in-a-rat-model-of-mandibular-distraction-osteogenesis
#7
Catherine N Tchanque-Fossuo, Alexis Donneys, Sagar S Deshpande, Deniz Sarhaddi, Noah S Nelson, Laura A Monson, Sara E Dahle, Steve A Goldstein, Steven R Buchman
BACKGROUND: Using distraction osteogenesis (DO) to regenerate robust endogenous bone could greatly enhance postoncologic reconstruction of head and neck cancer. However, radiation (XRT) corrosive effects still preclude DO's immense potential. We posit that adjunctive pretreatment with the radioprotectant amifostine (AMF) can optimize wound healing and allow for successful DO with quantifiable enhancements in bony union and strength despite previous surgical bed irradiation. METHODS: Two groups of murine left hemimandibles were exposed to a human equivalent radiation dosage fractionated over 5 daily doses of 7 Gy...
September 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28913298/the-unnecessity-of-positron-emission-tomography-computed-tomography-in-the-etiologic-evaluation-of-neurodevelopmental-delay-in-craniosynostosis-patients
#8
Chae Eun Yang, Eun Kyung Park, Myung Chul Lee, Kyu Won Shim, Yong Oock Kim
BACKGROUND: In evaluation of craniosynostosis patients in terms of neurodevelopmental delay, positron emission tomography computed tomography (PET-CT) scan can be used to assess brain abnormalities through glucose metabolism. We aimed to determine the unnecessity of PET-CT in this study. METHODS: Thirty-eight patients diagnosed with craniosynostosis who underwent distraction osteogenesis from October, 2010 to November, 2013 were reviewed. Magnetic resonance imaging (MRI) and PET-CT scan were carried out for evaluation of the brain structure and function, whereas X-ray and CT scan were taken for evaluation of the skull...
March 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28904587/complete-resolution-of-papilledema-in-syndromic-craniosynostosis-with-posterior-cranial-vault-distraction
#9
Melissa LoPresti, Edward P Buchanan, Veeral Shah, Caroline M Hadley, Laura A Monson, Sandi Lam
We report a case of surgical management of Crouzon syndrome with multisuture craniosynostosis presenting with increased intracranial pressure (ICP) manifesting with chronic papilledema without ventriculomegaly. A 12-month-old boy had complete resolution of papilledema after posterior cranial vault distraction followed by staged fronto-orbital advancement. Expansion of the cranial vault with posterior distraction osteogenesis posed an elegant treatment, obviating ventriculoperitoneal shunt placement for cerebrospinal fluid (CSF) diversion...
April 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28889181/humeral-lengthening-in-patients-with-achondroplasia-and-in-patients-with-post-septic-shortening-comparison-of-procedure-efficiency-and-safety
#10
Milud Shadi, Bartosz Musielak, Paweł Koczewski, Piotr Janusz
PURPOSE: Although humeral lengthening in patients with achondroplasia is an accepted procedure for improving functional status, there is still a paucity of information about the effectiveness of the method. Therefore, the aim of this study was to evaluate the efficacy and safety of humeral lengthening using monolateral fixators in patients with achondroplasia and unilateral shortening. METHODS: Twenty-one patients (31 humeri) were included in this study. The study group consisted of eight patients with achondroplasia (16 segments)...
September 9, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28884841/sclerostin-antibody-enhances-bone-formation-in-a-rat-model-of-distraction-osteogenesis
#11
Michelle M McDonald, Alyson Morse, Oliver Birke, Nicole Yc Yu, Kathy Mikulec, Lauren Peacock, Aaron Schindeler, Min Liu, Hua Zhu Ke, David G Little
Neutralizing monoclonal sclerostin antibodies are effective in promoting bone formation at a systemic level and in orthopedic scenarios including closed fracture repair. In this study we examined the effects of sclerostin antibody (Scl-Ab) treatment on regenerate volume, density and strength in a rat model of distraction osteogenesis. Surgical osteotomy was performed on 179 Sprague Dawley rats. After 1 week, rats underwent distraction for 2 weeks, followed by 6 weeks for consolidation. Two treatment groups received biweekly subcutaneous Scl-AbIII (a rodent form of Scl-Ab; 25 mg/kg), either from the start of distraction onwards or restricted to the consolidation phase...
September 8, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28869487/rhbmp-2-in-an-injectable-gelfoam-carrier-enhances-consolidation-of-the-distracted-callus-in-a-sheep-model
#12
T Floerkemeier, F Thorey, M Wellmann, C Hurschler, S Budde, H Windhagen
BACKGROUND: A major problem associated with distraction osteogenesis is the long time required for consolidation. OBJECTIVE: The goal of this study was to determine whether a percutaneous injection of recombinant human bone morphogenetic protein-2 (rhBMP-2) in a Gelfoam carrier would enhance bone consolidation following distraction. METHODS: A unilateral tibial osteotomy combined with external stabilization was performed in 14 adult sheep...
August 26, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28865846/application-of-a-newly-designed-mandibular-distraction-device-for-navigation-surgery-in-goats
#13
Ming Cai, Yang Chen, Xiaofeng Lu, Lei Xu, Xudong Wang, Guofang Shen
PURPOSE: This animal study is to investigate the accuracy of navigation-guided mandibular distraction osteogenesis with a special designed distraction device by TBNavis-CMFS navigation system. MATERIALS AND METHODS: Four goats were included in this study. The 3D simulation unilateral mandibular distraction osteogenesis was simulated for 14 mm lengthening in TBNavis-CMFS navigation system. A new designed mandibular distraction device with the detachable adapter for navigation surgery in combination with the specific mandibular dynamic reference frame was applied...
August 8, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28863881/does-guided-bone-regeneration-prevent-unfavorable-bone-shapes-in-distraction-gap
#14
Umut Demetoglu, Alper Alkan, Erdem Kiliç, Mustafa Ozturk, Suheyb Bilge
PURPOSE: Complications related to distraction osteogenesis can cause degradation of newly regenerated bone. Additionally, an unfavorable shape of the regenerated bone at the distraction gap can reduce the quantity of regenerated bone. The aim of the present study was to report on the prevention of unfavorable shapes of regenerated bone using guided bone regeneration during distraction. MATERIALS AND METHODS: Bilateral alveolar distraction was performed in 10 beagle dog mandibles...
August 5, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28853071/patterns-of-cell-matrix-interactions-during-formation-the-distraction-bone-regenerates
#15
N P Omelyanenko, I N Karpov
Multiple-day distraction regenerate contains a number of foci or zones merging into one another with different structural organization of the fibrocellular basis that reflects successive stages of reparative regeneration. At the moment of the last traction, the central part of the regenerate represents a zone of fibrogenesis (growth zone), which is common for the proximal and distal parts of the distraction regenerate. The other zones are paired and symmetrical: zones of angiogenesis, fibrous osteogenesis (primary), and osteogenesis (secondary)...
August 29, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28839409/profile-changes-and-stability-following-distraction-osteogenesis-with-rigid-external-distraction-in-adult-cleft-lip-and-palate-deformities
#16
Jaeson M Painatt, Ravi Veeraraghavan, Ushass Puthalath, Sherry Peter, Latha P Rao, Maria Kuriakose
OBJECTIVES: The objective of this study is to analyze the hard and soft-tissue profile changes as well as the upper airway changes after distraction osteogenesis (DO) using rigid external distraction device in adult cleft lip and palate (CLP) patients. The study also evaluates the stability of the surgical result. MATERIALS AND METHODS: Three lateral cephalometric radiographs were taken: Predistraction (T1), postdistraction (T2), and 1 year after distractor removal (T3)...
April 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/28831337/distraction-osteogenesis-for-brachymetatarsia-by-using-internal-device
#17
Reina Kitabata, Yoshiaki Sakamoto, Tomohisa Nagasao, Kazuo Kishi
Congenital brachymetatarsia most commonly involves the fourth ray and may be combined with metacarpal shortening. Now, many reports demonstrated the usefulness of distraction osteogenesis for lengthening of the metatarsals by using an external distraction device. In this article, we treated shortening fourth metatarsal by bone lengthening using the internal distraction device. This technique has some advantages over the method of external distraction.
July 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28826759/condylar-positions-before-and-after-bilateral-mandibular-distraction-osteogenesis-in-children-with-pierre-robin-sequence
#18
J Liu, Y Chen, F Li, W Wu, J Hao, D Luo, H Wang
This study aimed to analyze the changes in mandibular morphology after bilateral mandibular distraction osteogenesis (BMDO) in children with Pierre Robin sequence. The positions of the condyles were analyzed in reconstructed three-dimensional craniomaxillofacial images obtained for 18 children before and 8-12 weeks after BMDO. Differences between pre- and postoperative parameters were assessed using paired t-tests. After surgery, a significant decrease in superior joint space was detected (P<0.05), but no change in anterior joint space or posterior joint space was observed...
August 18, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28822675/precise-osteotomies-for-mandibular-distraction-in-infants-with-robin-sequence-using-virtual-surgical-planning
#19
C M Resnick
Mandibular distraction osteogenesis (MDO) has become the first-line operation in many centers for the management of obstructive sleep apnea (OSA) in infants with (Pierre) Robin sequence (RS) not relieved by non-surgical approaches. Preoperative virtual surgical planning (VSP) may improve precision and decrease complications for this operation. This article reports a retrospective study of RS infants who underwent MDO for OSA using preoperative VSP and three-dimensionally printed cutting guides performed by one surgeon...
August 16, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28818642/the-expression-of-endogenous-hydrogen-sulfide-signal-during-distraction-osteogenesis-in-a-rabbit-model
#20
X-W Jiang, Y Zhang, Y-Z Cheng, X-S Fan, X Deng, H-Y Peng
The hydrogen sulfide (H2S) signal system plays an important role in bone metabolism. However, the role of endogenous H2S during distraction osteogenesis (DO) remains unclear. Sixty-two male New Zealand White rabbits were subjected to right mandibular DO. Before distraction, the animals were divided randomly into two groups: group A, 0.5mm twice/day for 10 days; group B, 1.25mm twice/day for 4 days. Plasma and distraction gap tissue were harvested to determine the H2S signal. The osteogenesis effect was also evaluated...
August 14, 2017: International Journal of Oral and Maxillofacial Surgery
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