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Distraction osteogenesis

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https://www.readbyqxmd.com/read/27906844/effects-of-piezoelectric-surgery-on-bone-regeneration-following-distraction-osteogenesis-of-mandible
#1
Emre Tosun, Meric Bilgiç, Benay Yildirim, Hakan Hifzi Tüz, Taha Özer
The aim of this study is to compare the bone healing in the distraction gap following the osteotomy performed with piezoelectric and conventional devices for the distraction osteogenesis in the rabbit mandibles. Twelve rabbits were randomly divided into 2 groups; 6 for piezoelectric device and 6 for rotary instruments. After 3 days of latency period, distraction was started at a rate of 1 mm per day for 10 days. All the animals were sacrificed after 4 weeks of consolidation phase for histological and histomorphological evaluation...
November 30, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27876575/effects-of-collagen-membrane-application-and-cortical-bone-perforation-on-de-novo-bone-formation-in-periosteal-distraction-an-experimental-study-in-a-rabbit-calvaria
#2
Ken Nakahara, Maiko Haga-Tsujimura, Kosaku Sawada, Matthias Mottini, Benoit Schaller, Nikola Saulacic
OBJECTIVES: The aim of the present study was to assess the impact of collagen membrane application and cortical bone perforations in periosteal distraction osteogenesis. STUDY DESIGN: A total of 32 New Zealand rabbits were randomized into four experimental groups, considering two treatment modalities. Calvarial bone was perforated or left intact (P+/-). In half the animals, the distraction mesh was covered with a collagen membrane (M+/-). All animals were subjected to a 7-day latency period and a 10-day distraction period...
September 28, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27875515/reconstruction-of-congenital-mandibular-hypoplasia-with-microvascular-free-fibula-flaps-in-the-pediatric-population-a-paradigm-shift
#3
Emily C Cleveland, Jamie Zampell, Tomer Avraham, Z-Hye Lee, David Hirsch, Jamie P Levine
BACKGROUND: The microvascular free fibula flap has become the gold standard for reconstruction of complex mandibular defects since its description by Hidalgo in 1989. Prior studies have demonstrated its safety and efficacy in the pediatric population. However, this reconstructive method is often used only as a last resort for correction of congenital mandibular hypoplasia, after failure of bone grafting and distraction osteogenesis. The authors describe our experience using this technique, facilitated by virtual planning and prefabricated cutting jigs, for children with severe congenital mandibular hypoplasia...
November 21, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27845963/internal-distraction-osteogenesis-with-piezosurgery-oblique-osteotomy-of-supraorbital-margin-of-frontal-bone-for-the-treatment-of-unilateral-coronal-synostosis
#4
Weimin Shen, Jie Cui, Jianbing Chen, Yi Ji, Liangliang Kong
PURPOSE: To assess the utility of internal distraction osteogenesis with Piezosurgery oblique osteotomy of supraorbital margin of frontal bone for the treatment of unilateral coronal synostosis and to study the outcome and complications of this procedure. Oblique osteotomy allows for entry into the cranial cavity, and along with parallel cut to the roof of the orbit, avoids the need to cut into the orbit which forms the frontal flap. METHODS: Oblique osteotomy was performed along the supraorbital rim to do a frontal suture of the glabella (ages of patients were less than 1 year) or on the opposite side of the supraorbital rim (ages of patients were older than 1 year) after performing a suturectomy of the effected coronal suture...
November 15, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27833343/distraction-osteogenesis-for-management-of-severe-osa-in-pierre-robin-sequence-an-approach-to-elude-tracheostomy-in-infants
#5
N K Sahoo, I D Roy, Shamsher Dalal, Amit Bhandari
BACKGROUND: Severe obstructive sleep apnoea (OSA) is a life threatening condition associated with Pierre Robin sequence (PRS) due to mandibular micrognathia and glossoptosis. Often these patients require tracheostomy at an early age which has high morbidity. Distraction osteogenesis (DO) is an accepted method of treatment for patients with hypoplastic mandible to achieve mandibular lengthening without need for a bone graft. It has also been used in respiratory distressed neonates and infants to avoid tracheostomy...
December 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27833342/hard-and-soft-tissue-changes-following-maxillary-distraction-osteogenesis-and-mandibular-setback-with-bilateral-sagittal-split-osteotomy
#6
Shilpa S Bawane, Neelam N Andrade
AIMS OF THIS STUDY: (1) To highlight the role of intraoral submerged device in distraction osteogenesis (DO) of patients requiring two jaw surgeries for the correction of severe developmental maxillary hypoplasia (MH) and mandibular prognathism (MP) (2) To analyse the hard and soft tissue changes following maxillary DO and mandibular setback with bilateral sagittal split osteotomy (BSSO) in patients with severe MH and MP requiring two jaw surgeries. MATERIALS AND METHODS: During the period Jan 2004 to Dec 2006, five patients with severe developmental MH along with MP were treated...
December 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27826456/evaluating-loading-deflection-of-distraction-osteogenic-rib-in-a-rabbit-model
#7
Weimin Shen, Chenlu Tang, Junyi Yang, Liangliang Kong, Xiaoying Zhang
BACKGROUND: The treatment of patients with partially atrophic rib and rib defects requires an ideal arc of the rib that has adequate bone length and width. To design and assemble a distraction device with a strain gauge, we need to establish an animal model for testing it during rib distraction osteogenesis. METHODS: Osteotomies were performed at the same position in the fifth rib in 8 rabbits. Customized distraction devices attached to strain gauges were used to distract the ribs...
October 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27825991/cyp24a1-deficiency-does-not-affect-bone-regeneration-in-distraction-osteogenesis
#8
REVIEW
Abdallah Husseini, René St-Arnaud
The putative biological activity of 24,25-(OH)2D remains unclear. Previous studies showed an increase in the circulating levels of this metabolite following fracture in chicks. Our laboratory has generated a mouse model deficient for the Cyp24a1 gene for studying the role of 24,25-(OH)2D. We set out to study the role of CYP24A1 and 24,25-(OH)2D in intramembranous bone formation during distraction osteogenesis in wild-type and Cyp24a1-deficient mice. Distraction osteogenesis was applied to mouse tibiae using a miniature external fixator apparatus...
November 5, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27815946/distraction-osteogenesis-of-the-fibula-to-correct-ankle-valgus-in-multiple-hereditary-exostoses
#9
Alice Chu, Crispin Ong, Eric R Henderson, Harold J P Van Bosse, David S Feldman
Gradual distal fibula lengthening (DFL), in conjunction with other procedures, was used to correct ankle valgus and short fibulae in three pediatric patients with multiple hereditary exostoses (MHE). The average amount of DFL was 15 mm with a mean follow-up of 2.9 years. Final radiographs showed that all three patients had a stable ankle mortise without evidence of talar tilt or widening. In conclusion, gradual DFL has the advantage of restoring anatomy in cases of ankle valgus due to short fibulae and MHE, and may be performed in conjunction with other procedures...
November 2016: Bulletin of the Hospital for Joint Diseases
https://www.readbyqxmd.com/read/27779806/role-of-parathyroid-hormone-in-regeneration-of-irradiated-bone-in-a-murine-model-of-mandibular-distraction-osteogenesis
#10
Stephen Y Kang, Sagar S Deshpande, Alexander R Zheutlin, Alexis Donneys, Jose J Rodriguez, Noah S Nelson, Peter A Felice, Douglas B Chepeha, Steven R Buchman
BACKGROUND: The purpose of this study was to measure the histologic and histomorphometric effects of parathyroid hormone (PTH) treatment on irradiated bone undergoing distraction osteogenesis (DO). METHODS: Thirty-four rats were divided into 3 groups. The control group underwent DO and the radiation control group underwent radiotherapy (RT) before DO. The PTH group underwent RT and received PTH during DO. Quantitative histology and histomorphometry were performed...
October 25, 2016: Head & Neck
https://www.readbyqxmd.com/read/27766028/targeting-p38-pathway-regulates-bony-formation-via-msc-recruitment-during-mandibular-distraction-osteogenesis-in-rats
#11
Zi-Hui Yang, Bao-Lei Wu, Chen Ye, Sen Jia, Xin-Jie Yang, Rui Hou, De-Lin Lei, Lei Wang
Distraction osteogenesis (DO) is a widely used self-tissue engineering. However, complications and discomfort due to the long treatment period are still the bottleneck of DO. Novel strategies to accelerate bone formation in DO are still needed. P38 is capable of regulating the osteogenic differentiation of both mesenchymal stem cells (MSCs) and osteoblasts, which are crucial to bone regeneration. However, it is not clear whether targeting p38 could regulate bony formation in DO. The purpose of the current work was to investigate the effects of local application of either p38 agonist anisomycin or p38 inhibitor SB203580 in a rat model of DO...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27765472/treatment-of-post-traumatic-elbow-deformities-in-children-with-the-ilizarov-distraction-osteogenesis-technique
#12
Cenk Özkan, Mehmet Ali Deveci, Mustafa Tekin, Ömer Sunkar Biçer, Kadir Gökçe, Mahir Gülşen
OBJECTIVE: The present study assessed functional and radiographic outcomes of distraction osteogenesis treatment of post-traumatic elbow deformities in children. METHODS: Eight children were treated between 2008 and 2013 for post-traumatic elbow deformities using distraction osteogenesis. Mean age at time of operation was 10.9 years. Six patients had varus and 2 had valgus deformity. Magnitude of correction, fixator index, complications, carrying angle, and elbow range of motion were assessed...
October 17, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27761391/a-novel-step-osteotomy-for-correction-of-hemifacial-microsomia-a-case-report
#13
Debraj Howlader, Dichen P Bhutia, U Vignesh, Divya Mehrotra
Facial asymmetry is one of the commonest facial anomalies, with reported incidence as high as 34%. Hemifacial microsomia (HFM) has an incidence of 1 in every 4000-5600 children and is one of the commonest causes of facial asymmetry. The standard treatment of HFM is orthognathic surgery by bilateral saggital split osteotomy (BSSO) or distraction osteogenesis (DO) of the mandible, both of which involve prolonged periods of occlusal adjustments by an orthodontist. Here, we present distraction of the mandible by means of a novel modified step osteotomy to correct the facial asymmetry in a case of hemifacial microsomia without disturbing the occlusion...
September 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27755413/coronal-split-corpus-osteotomy-of-the-mandible-a-modified-visor-osteotomy-technique-for-bone-volume-enhancement
#14
Mustafa Sancar Ataç, Yeliz Kilinç
The bony augmentation of severely atrophied mandible is generally required for the purposes of prosthetic rehabilitations. The treatment strategies have been well defined in the literature ranging from osteotomy techniques to distraction osteogenesis. Visor osteotomy is the milestone of the reconstructive surgery for the atrophied mandible which has received some modifications. In the present study, the authors describe a new modification of visor osteotomy in which a complete coronal split osteotomy down to the inferior border at the mental region has been performed...
October 14, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27755412/osteodistraction-with-dental-implant-borne-devices-for-bone-regeneration-in-atrophied-premaxilla
#15
Francesco Carlino, Gian Piero Villani, Andrea Berti, Giuseppe Pantaleo, Antonio Cortese, Pier Paolo Claudio
Aim of this work is to present the evolution of an innovative technique for tooth/implant supported bone distraction, leading to proper oral rehabilitation in patients with atrophic alveolar bone, even when a complete premaxilla expansion is needed, or in patients in whom implants were already present, but inserted in wrong position.Distraction osteogenesis was selected because of its moderate invasiveness, the few surgical steps needed, and the proper cost/benefits balance. This procedure is particularly suited for young patients with remarkable aesthetic demands related to active social and working life, as for elderly patients expecting lower surgical stress and risks...
October 14, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27752211/early-mandibular-distraction-to-relieve-robin-severe-airway-obstruction-in-two-siblings-with-lymphedema-distichiasis-syndrome
#16
Paola Papoff, Marco Castori, Lucia Manganaro, Fabio Midulla, Corrado Moretti, Piero Cascone
Although micrognathia and cleft palate have been reported in patients with Lymphedema-distichiasis syndrome (LDS), the classic Robin sequence with glossoptosis and airway obstruction has not been previously described in patients with genetically confirmed LDS. Here we report on two female siblings with LDS confirmed by a FOXC2 mutation who presented at birth with severe airway obstruction related to Robin sequence. Respiratory obstruction was successfully managed by early distraction osteogenesis. Our report highlights the unusual occurrence of Robin sequence in LDS patients and advises distraction osteogenesis to resolve breathing problems in LDS patients who present with Robin related severe airway obstruction...
September 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27727105/ckip-1-silencing-promotes-new-bone-formation-in-rat-mandibular-distraction-osteogenesis
#17
Zi-Chao Zhou, Lei Che, Liang Kong, De-Lin Lei, Rui Liu, Xin-Jie Yang
OBJECTIVE: This study investigated the effects and possible molecular mechanism of casein kinase-2 interacting protein-1 (CKIP-1) silencing on bone regeneration during rat mandibular distraction osteogenesis (DO). STUDY DESIGN: CKIP-1 silencing by chitosan/si-CKIP-1 was employed and analyzed both in rat mandibular DO models in vivo and in cultured rat mandible bone marrow stromal cells (BMSCs) in vitro. RESULTS: Gross observation, micro-computed tomography analysis, and hematoxylin and eosin (H&E) staining revealed that new bone formation in the distraction gap of the chitosan/si-CKIP-treated group was better compared with the chitosan/si-NC and phosphate buffered saline-treated groups in both quantity and quality...
July 30, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27713061/the-total-calvarial-trans-sutural-distraction-osteogenesis-tc-tsudo-for-26-children-with-slit-ventricle-craniosynostosis-or-microcephaly-after-shunt-operation
#18
Dong Ha Park, Soo Han Yoon
OBJECTIVE: Among shunt complications, the post-shunt slit ventricle (PSSV) and the post-shunt craniosynostosis (PSCS) may be managed by shunt valve upgrade and/or cranial expansion surgery. Here, we analyzed 26 children with PSSV and/or PSCS who received simple generalized cranial expansion, i.e., total calvarial trans-sutural distraction osteogenesis (TC-TSuDO). METHODS: Among 254 children with shunt surgery, 26 children received TC-TSuDO. These 26 children included of 14 with PSSV, 4 with PSCS, and 8 with both PSSV and PSCS...
October 3, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27712818/nonsyndromic-craniosynostosis-and-deformational-head-shape-disorders
#19
Lisa M Morris
This article provides an overview of etiology, epidemiology, pathology, diagnosis, and treatment of nonsyndromic craniosynostosis, including sagittal, metopic, coronal, lambdoid, and complex synostosis. Detailed discussion is presented regarding indications for surgical intervention and management options, including frontoorbital advancement, cranial vault reconstruction, endoscopic strip craniectomy, spring-assisted strip craniectomy, and cranial vault distraction osteogenesis. Deformational plagiocephaly is also presented with treatment options including repositioning, physical therapy, and helmet therapy...
November 2016: Facial Plastic Surgery Clinics of North America
https://www.readbyqxmd.com/read/27694596/prospective-randomised-comparison-of-ring-versus-rail-fixator-in-infected-gap-nonunion-of-tibia-treated-with-distraction-osteogenesis
#20
R Rohilla, J Wadhwani, A Devgan, R Singh, M Khanna
AIMS: This is a prospective randomised study which compares the radiological and functional outcomes of ring and rail fixators in patients with an infected gap (> 3 cm) nonunion of the tibia. PATIENTS AND METHODS: Between May 2008 and February 2013, 70 patients were treated at our Institute for a posttraumatic osseocutaneous defect of the tibia measuring at least 3 cm. These were randomised into two groups of 35 patients using the lottery method. Group I patients were treated with a ring fixator and group II patients with a rail fixator...
October 2016: Bone & Joint Journal
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