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Distraction osteogenesis

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https://www.readbyqxmd.com/read/28647818/assessment-of-the-effect-of-systemic-delivery-of-sclerostin-antibodies-on-wnt-signaling-in-distraction-osteogenesis
#1
Mohammad M Alzahrani, Asim M Makhdom, Frank Rauch, Dominique Lauzier, Maria Kotsiopriftis, Saber Ghadakzadeh, Reggie C Hamdy
Sclerostin is a known inhibitor of the Wnt signaling pathway which is involved in osteogenesis and, when inactivated, stimulates bone formation. To our knowledge, this effect has not been studied in the context of distraction osteogenesis (DO). Tibial DO was conducted on a total of 24 wild-type mice, which were then divided into 2 groups-a saline injection group (control) and an anti-sclerostin (Scl-Ab) injection group (treatment). The mice in the treatment group received 100 mg/kg intravenous injections of the antibody weekly until killing...
June 24, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28643081/distraction-osteogenesis-reconstruction-of-large-segmental-bone-defects-after-primary-tumor-resection-pitfalls-and-benefits
#2
REVIEW
Jan Lesensky, Daniel E Prince
Successful cure is achieved in almost 70% of patients with primary bone sarcomas with currently available therapies. Some soft tissue sarcomas require wide bone resection in order to achieve appropriate margins for cure of disease, and patients undergoing these procedures need durable reconstruction. Biological reconstruction has been shown to provide patients with superior long-term results over other alternatives. Distraction osteogenesis is well studied in the correction of deformities as well as in addressing some congenital musculoskeletal pathologies...
June 22, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28639529/circular-external-fixation-and-cemented-pmma-spacers-for-the-treatment-of-complex-tibial-fractures-and-infected-nonunions-with-segmental-bone-loss
#3
Andries H van Niekerk, Franz F Birkholtz, Phillip de Lange, Kevin Tetsworth, Erik Hohmann
PURPOSE: The purpose of this study was to compare the outcome of combined circular external fixation and cemented polymethylmethacrylate (PMMA) spacer application between a cohort of patients with grade 3 open fractures and infected tibial nonunions and concomitant segmental bone loss. METHODS: The study was designed as a retrospective cohort study. All patients who were treated for complex tibial fractures or infected nonunions with segmental bone loss between 2009 and 2013 were included if they were aged between 16 years and 60 years, sustained acute traumatic grade 3 open tibial fractures, presented with infected nonunion, and were followed up for a minimum of 12 months...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28634158/stem-cell-therapy-for-enhancement-of-bone-consolidation-in-distraction-osteogenesis-a-contemporary-review-of-experimental-studies
#4
Y Yang, S Lin, B Wang, W Gu, G Li
OBJECTIVES: Distraction osteogenesis (DO) mobilises bone regenerative potential and avoids the complications of other treatments such as bone graft. The major disadvantage of DO is the length of time required for bone consolidation. Mesenchymal stem cells (MSCs) have been used to promote bone formation with some good results. METHODS: We hereby review the published literature on the use of MSCs in promoting bone consolidation during DO. RESULTS: Studies differed in animal type (mice, rabbit, dog, sheep), bone type (femur, tibia, skull), DO protocols and cell transplantation methods...
June 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28623826/mechanical-characterization-via-nanoindentation-of-the-woven-bone-developed-during-bone-transport
#5
J Mora-Macías, A Pajares, P Miranda, J Domínguez, E Reina-Romo
Nanoindentation has been used successfully in the determination of the mechanical properties of bone. Its application in fracture healing provides information on the evolution of material properties of the woven bone during regeneration process. However, this technique has not been applied in assessing the mechanical properties of woven bone during distraction osteogenesis. Therefore, the aim of this work is to evaluate the spatial and temporal variations of the elastic modulus of the woven bone generated during the bone transport process...
June 1, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28610820/mandibular-symphyseal-midline-distraction-osteogenesis-for-micrognathia-associated-with-aglossia-and-situs-inversus-totalis
#6
X C Ren, Y F Li, Y Liu, S S Zhu
Aglossia is a rare congenital abnormality, often associated with micrognathia and limb defects. Situs inversus totalis is also a rare congenital abnormality, defined as a mirror-image reversal of all the asymmetric organs of the thorax and abdomen. The concurrence of these two abnormalities has only been reported in eight similar cases in the literature. Although micrognathia and malocclusion were observed in all of these cases, few treatments were performed for the patients' dentofacial deformities. This report describes the case of a 7-year-old boy suffering from micrognathia, aglossia, and situs inversus totalis simultaneously, and the treatment for his micrognathia by mandibular symphyseal midline distraction osteogenesis, guided by virtual surgical planning and a three-dimensional printed surgical template...
June 10, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28610544/the-biomechanical-properties-of-human-craniofacial-sutures-and-relevant-variables-in-sutural-distraction-osteogenesis-a-critical-review
#7
Fabio Savoldi, James Kh Tsoi, Corrado Paganelli, Jukka P Matinlinna
Sutures are synarthroses connecting the bones of the head each other through a fibrous sutural ligament. The knowledge of their biomechanical properties is relevant in the application of regenerative techniques for the treatment of craniofacial conditions, such as the sutural distraction osteogenesis (SDO). However, their mechanical characterisation has not received a systematic approach, and both clinical treatments and virtual simulations lack of clear mechanical parameters. Online databases (PubMed©, Cochrane Library©, Google Scholar©), references of full-text articles, and previous reviews of the literature were searched...
June 13, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28599124/three-dimensional-reconstruction-of-post-traumatic-deficient-anterior-maxilla
#8
Adi Rachmiel, Dekel Shilo, Dror Aizenbud, Mark Pen, Dana Rachmiel, Omri Emodi
PURPOSE: Maxillary retrognathism appears in 14.3% of patients exhibiting malocclusion after trauma treatment. This report describes the application of alveolar distraction osteogenesis (ADO) for treating the severely deficient anterior maxilla after trauma injuries in the vertical and anteroposterior planes. MATERIALS AND METHODS: This is a retrospective study of patients exhibiting severe vertical and anteroposterior maxillary bone deficiency after trauma injuries and treated by ADO as a first stage with additional Le Fort I advancement when required...
May 15, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28585185/intercalary-reconstructions-after-bone-tumor-resections-a-review-of-treatments
#9
REVIEW
Georgios N Panagopoulos, Andreas F Mavrogenis, Cyril Mauffrey, Jan Lesenský, Andrea Angelini, Panayiotis D Megaloikonomos, Vasilios G Igoumenou, John Papanastassiou, Olga Savvidou, Pietro Ruggieri, Panayiotis J Papagelopoulos
An intercalary reconstruction is defined as replacement of the diaphyseal portion of a long bone after segmental skeletal resection (diaphysectomy). Intercalary reconstructions typically result in superior function compared to other limb-sparing procedures as the patient's native joints above and below the reconstruction are left undisturbed. The most popular reconstructive options after segmental resection of a bone sarcoma include allografts, vascularized fibula graft, combined allograft and vascularized fibula, segmental endoprostheses, extracorporeal devitalized autograft, and segmental transport using the principles of distraction osteogenesis...
June 5, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28582295/cephalometric-improvement-of-severe-microretrognathia-with-an-anterior-open-bite-using-curvilinear-mandibular-distraction-osteogenesis
#10
Jing Li, Patrick A Gerety, Wen Xu, Scott P Bartlett, Jesse A Taylor
Curvilinear mandibular distraction osteogenesis (MDO) provides for multidimensional augmentation and rotation in mandibles with complex, abnormal morphology. This study aims to demonstrate cephalometric changes after curvilinear MDO.A prospectively maintained craniofacial database was queried for patients undergoing curvilinear MDO from 2009 to 2015. Demographic and operative data were collected. Cephalometric measurements were obtained from preoperative and postdistraction imaging, including sella-nasion-B point angle (SNB), mandibular plane angle (MPA), occlusal plane angle (OPA), and gonial angle (GA)...
June 2, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28570459/alar-pinning-in-rigid-external-distraction-for-midfacial-hypoplasia
#11
Jenny L Yu, Albert S Woo
BACKGROUND: Distraction osteogenesis with a rigid external distractor is a widely accepted treatment for midfacial hypoplasia. In this study, the authors introduce the utilization of alar pinning with the external halo distractor for maxillary advancement, in place of an oral splint. METHODS: A retrospective chart review was conducted of 7 patients who successfully underwent distraction osteogenesis using the alar pinning technique. Midfacial hypoplasia was secondary to Crouzon syndrome (n = 4), Apert syndrome (n = 1), Pfeiffer syndrome (n = 1), or bacterial meningitis (n = 1)...
May 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28570398/patient-with-cleft-maxillary-hypoplasia-who-underwent-distraction-osteogenesis-and-conservative-therapies-to-postoperative-velopharyngeal-insufficiency
#12
Katsu Takahashi, Khaled Gamal Dahy, Kazuyuki Saito, Hiromu Masuoka, Shigehiko Suzuki, Kazuhisa Bessho
The authors performed distraction osteogenesis using The Maxillary Distractor System (SYNTHES) to maxillary hypoplasia patient with cleft lip palate, and consequently improved the aesthetic complexion of the patient. Velopharyngeal insufficiency developed after bone elongation; the authors improved the insufficiency with conservative therapies such as articulatory training using the bulb attached palatal lift prosthesis. And then the authors got successful and accepted postoperative speech outcome.
May 31, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28562424/biology-of-bone-formation-fracture-healing-and-distraction-osteogenesis
#13
Christopher M Runyan, Kyle S Gabrick
Distraction osteogenesis is a bone-regenerative process in which an osteotomy is followed by distraction of the surrounding vascularized bone segments, with formation of new bone within the distraction gap. Distraction osteogenesis is efficacious for reconstructing critical sized bony defects in the appendicular and craniofacial skeleton. To provide opportunity to expand applications of distraction osteogenesis, it is important to have a thorough understanding of the underlying molecular biology and physiology of bone development and fracture healing...
May 29, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28542074/nerve-regeneration-and-functional-recovery-with-neurorrhaphy-performed-at-the-early-distraction-osteogenesis-an-experimental-study
#14
Byung Jun Kim, Jeong Mok Cho, Sung Tack Kwon
Distraction osteogenesis is widely used in many clinical situations, but distraction in cases accompanying nerve injury has been avoided due to concern of unfavorable effect on nerve regeneration by traction. This study evaluated the feasibility of early distraction lengthening after neurorrhaphy. Thirty-six rats were evenly distributed into 3 groups (12 rats in each group); neurorrhaphy and distraction (group I), neurorrhaphy and osteotomy without distraction (group II), and only distraction without neurorrhaphy (group III), respectively...
July 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28538077/monobloc-frontofacial-or-le-fort-iii-distraction-osteogenesis-in-syndromic-craniosynostosis-three-dimensional-evaluation-of-treatment-outcome-and-the-need-for-central-distraction
#15
Ching-Hsuan Hu, Chieh-Tsai Wu, Ellen Wen-Ching Ko, Philip Kuo-Ting Chen
BACKGROUND: The objectives of this study were to investigate the treatment effect, morphology, and volumetric outcomes of monobloc frontofacial or Le Fort III distraction osteogenesis in syndromic craniosynostosis by 3-dimensional evaluation. MATERIALS AND METHODS: Nine consecutive patients underwent monobloc frontofacial or Le Fort III distraction during 2003 to 2012 were included and evaluated. The patient's evaluation is a minimum of a 4-year follow-up. Pretreatment, post-treatment advancement, and relapse were quantified...
May 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28538064/temporomandibular-joint-ankylosis-after-early-mandibular-distraction-osteogenesis-a-new-syndrome
#16
Manlio Galié, Valentina Candotto, Giovanni Elia, Luigi C Clauser
Distraction osteogenesis (DO) has been one of the most innovative concepts in cranio-maxillofacial syndromology and surgery over the last 25 years.Early mandibular distraction in severe micrognathia has recently been recognized as an effective treatment option to safely relieve upper airway obstruction associated with mandibular deficiency.An increased incidence in temporomandibular joint complications during DO in neonates has recently been reported, especially in syndromic patients.The authors report 2 children affected by severe micrognathia and severe respiratory distress at birth...
May 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28500874/effects-of-intermittent-low-dose-parathyroid-hormone-treatment-on-rapid-mandibular-distraction-osteogenesis-in-rabbits
#17
Bin Ye, Yunfeng Li, Songsong Zhu, Shengjun Sun, Jing Hu, Shujuan Zou
PURPOSE: To determine whether low-dose recombinant human parathyroid hormone (rhPTH) would have a beneficial effect on regenerate healing and surrounding bone in a rabbit model of rapid mandibular distraction osteogenesis (DO). MATERIALS AND METHODS: Twenty-eight rabbits underwent unilateral mandibular lengthening at a rapid rate of 2 mm per day for 5 days. From the first day of DO, the experimental group received daily subcutaneous injections of rhPTH 10 μg/kg for 30 days and the control group received the same volume of saline (n = 14 in each group)...
April 19, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28499465/current-treatment-of-infected-non-union-after-intramedullary-nailing
#18
H Simpson, S T J Tsang
Non-union is a devastating consequence of a fracture. Non-unions cause substantial patient morbidity with patients suffering from loss of function of the affected extremity, increased pain, and a substantial decrease in the quality of life. The management is often associated with repeated, unsuccessful operations resulting in prolonged hospital stays, which has social and economic consequences to both the patient and the healthcare system. The rates of non-union following intramedullary (IM) nailing vary according to anatomical location...
May 9, 2017: Injury
https://www.readbyqxmd.com/read/28486286/practical-aspects-of-posttrauma-reconstruction-with-an-intramedullary-lengthening-nail
#19
Mitchell Bernstein
Limb equalization using the Ilizarov method has evolved and adapted the use of internal lengthening devices. One of the newest devices, termed "PRECICE," is a magnetically controlled telescoping nail. Complications such as pin site infection and skin irritation are eliminated. Despite trauma surgeons' familiarity with intramedullary nailing, the Ilizarov method requires sound knowledge of deformity analysis and awareness of specific complications associated with distraction osteogenesis. This manuscript discusses some of the practical preoperative and intraoperative components of limb lengthening...
June 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28485552/effect-of-strontium-citrate-on-bone-consolidation-during-mandibular-distraction-osteogenesis
#20
Benjamin A Taylor, Michael Bezuhly, Matthew Brace, Michael Carter, Paul Hong
OBJECTIVES/HYPOTHESIS: Mandibular distraction osteogenesis (MDO) involves a lengthy consolidation phase where complications can occur. Strontium is an element that has been shown to improve bone healing. The objective of this study was to determine whether strontium citrate can be used to enhance bone healing during MDO in a rabbit model. STUDY DESIGN: Prospective animal model study. METHODS: Custom-made MDO devices were placed on 20 New Zealand White rabbits...
May 9, 2017: Laryngoscope
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