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Fluid retention

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https://www.readbyqxmd.com/read/28318850/safety-and-efficacy-of-hyperosmolar-irrigation-solution-in-shoulder-arthroscopy
#1
Nicholas M Capito, James L Cook, Bernardo Yahuaca, Marie D Capito, Seth L Sherman, Matthew J Smith
BACKGROUND: A hyperosmolar irrigation solution has been reported to be safe and have potential benefits for use during shoulder arthroscopy in an animal model study. In this study, the clinical effects of a hyperosmolar solution were compared with a standard isotonic solution when used for shoulder arthroscopy. METHODS: A prospective, double-blind, randomized controlled trial was performed to compare isotonic (273 mOsm/L) and hyperosmolar (593 mOsm/L) irrigation solutions used for arthroscopic rotator cuff repair...
March 15, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28315409/in-vivo-tau-pet-imaging-in-dementia-pathophysiology-radiotracer-quantification-and-a-systematic-review-of-clinical-findings
#2
REVIEW
Benjamin Hall, Elijah Mak, Simon Cervenka, Franklin I Aigbirhio, James B Rowe, John T O'Brien
In addition to the deposition of β-amyloid plaques, neurofibrillary tangles composed of aggregated hyperphosphorylated tau are one of the pathological hallmarks of Alzheimer's disease and other neurodegenerative disorders. Until now, our understanding about the natural history and topography of tau deposition has only been based on post-mortem and cerebrospinal fluid studies, and evidence continues to implicate tau as a central driver of downstream neurodegenerative processes and cognitive decline. Recently, it has become possible to assess the regional distribution and severity of tau burden in vivo with the development of novel radiotracers for positron emission tomography (PET) imaging...
March 14, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28314480/airways-antiallergic-effect-and-pharmacokinetics-of-alkaloids-from-alstonia-scholaris
#3
Yun-Li Zhao, Jing Cao, Jian-Hua Shang, Ya-Ping Liu, Afsar Khan, Heng-Shan Wang, Yi Qian, Lu Liu, Min Ye, Xiao-Dong Luo
BACKGROUND: Alstonia scholaris (L.) R. Br. (Apocynaceae), an important herbal medicine, has been widely used to treat respiratory tract diseases, such as cough, asthma, phlegm, and chronic obstructive pulmonary disease. PURPOSE: To evaluate pharmacological effect of alkaloids from A. scholaris on ovalbumin induced airways allergic inflammatory model, and explore whether the dosing frequency is related to pharmacokinetics. STUDY DESIGN: After oral administration of total alkaloids, the pharmacokinetic study of it was investigated...
April 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28314103/computational-study-of-the-forces-driving-aggregation-of-ultrasmall-nanoparticles-in-biological-fluids
#4
Sergio A Hassan
Nanoparticle (NP) aggregation can lead to prolonged retention in tissues or embolism, among other adverse effects. Successful use in biomedicine thus requires the capability to make NPs with limited aggregative potential. Rational design is presently a challenge due to incomplete knowledge of their interactions in biofluids. Recently, ultrasmall gold NPs passivated with endogenous antioxidant glutathione have shown promise for use in vivo. Computer simulations are here conducted to identify the forces underlying aggregation (or lack thereof) of these NPs in a cell culture...
March 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28294964/alginate-based-composite-sponges-as-gastroretentive-carriers-for-curcumin-loaded-self-microemulsifying-drug-delivery-systems
#5
Arpa Petchsomrit, Namfa Sermkaew, Ruedeekorn Wiwattanapatapee
Alginate-based composite sponges were developed as carriers to prolong the gastric retention time and controlled release of curcumin-loaded self-microemulsifying drug delivery systems (Cur-SMEDDS). Liquid Cur-SMEDDS was incorporated into a solution made up of a mixture of polymers and converted into a solid form by freeze-drying. The ratio of alginate as the main polymer, adsorbent (colloidal silicon dioxide), and additional polymers-sodium carboxymethyl cellulose (SCMC), hydroxypropyl methylcellulose (HPMC)-was varied systematically to adjust the drug loading and entrapment efficiency, sponge buoyancy, and the release profile of Cur-SMEDDS...
March 15, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28289667/laparoscopic-cholecystectomy-under-spinal-epidural-anesthesia-vs-general-anaesthesia-a-prospective-randomised-study
#6
Turgut Donmez, Vuslat Muslu Erdem, Sinan Uzman, Dogan Yildirim, Huseyin Avaroglu, Sina Ferahman, Oguzhan Sunamak
PURPOSE: Laparoscopic cholecystectomy (LC) is usually performed under the general anesthesia (GA). Aim of the study is to investigate the availability, safety and side effects of combined spinal/epidural anesthesia (CSEA) and comparison it with GA for LC. METHODS: Forty-nine patients who have a LC plan were included into the study. The patients were randomly divided into GA (n = 25) and CSEA (n = 24) groups. Intraoperative and postoperative adverse events, postoperative pain levels were compared between groups...
March 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28287043/healthcare-and-economic-burden-of-adverse-events-among-patients-with-chronic-myelogenous-leukemia-treated-with-bcr-abl1-tyrosine-kinase-inhibitors
#7
Jay Lin, Dinara Makenbaeva, Melissa Lingohr-Smith, Robyn Bilmes
OBJECTIVES: BCR-ABL1 tyrosine kinase inhibitors (TKIs) are established treatments for chronic myelogenous leukemia (CML); however, they are associated with infrequent, but clinically serious adverse events (AEs). The objective of this analysis was to assess healthcare resource utilization and costs associated with AEs, previously identified using the FDA Adverse Event Reporting System (FAERS) in another study, among TKI-treated patients. METHODS: Adult patients with ≥1 inpatient or ≥2 outpatient ICD-9-CM diagnosis codes for CML and ≥1 claim for a TKI treatment between January 1, 2006 and September 30, 2012 were identified from the Commercial and Medicare MarketScan databases...
March 12, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28280338/a-novel-ion-exchange-carrier-based-upon-liposome-encapsulated-montmorillonite-for-ophthalmic-delivery-of-betaxolol-hydrochloride
#8
Yi Huang, Qi Tao, Dongzhi Hou, Sheng Hu, Shuangyan Tian, Yanzhong Chen, Ruyi Gui, Lingling Yang, Yao Wang
As a novel ion-exchange carrier with high surface area and excellent exchangeability, montmorillonite (Mt) was intercalated with betaxolol hydrochloride (BH) to form a nanocomposite and then encapsulated by liposomes (Mt-BH-LPs) for an ophthalmic drug-delivery system. The Mt-BH and Mt-BH-LPs were prepared by an acidification process and ethanol injection combined with ammonium sulfate gradient methods. The successful formation of Mt-BH and Mt-BH-LPs was verified by thermogravimetric analysis, X-ray diffraction, Fourier-transform infrared spectra, and transmission electron microscopy...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28274250/prosthetic-joint-infection-development-of-an-evidence-based-diagnostic-algorithm
#9
Heinrich M L Mühlhofer, Florian Pohlig, Karl-Georg Kanz, Ulrich Lenze, Florian Lenze, Andreas Toepfer, Sarah Kelch, Norbert Harrasser, Rüdiger von Eisenhart-Rothe, Johannes Schauwecker
BACKGROUND: Increasing rates of prosthetic joint infection (PJI) have presented challenges for general practitioners, orthopedic surgeons and the health care system in the recent years. The diagnosis of PJI is complex; multiple diagnostic tools are used in the attempt to correctly diagnose PJI. Evidence-based algorithms can help to identify PJI using standardized diagnostic steps. METHODS: We reviewed relevant publications between 1990 and 2015 using a systematic literature search in MEDLINE and PUBMED...
March 9, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28272337/impact-of-isotonic-beverage-on-the-hydration-status-of-healthy-chinese-adults-in-air-conditioned-environment
#10
Phei Ching Siow, Wei Shuan Kimberly Tan, Christiani Jeyakumar Henry
People living in tropical climates spend much of their time in confined air-conditioned spaces, performing normal daily activities. This study investigated the effect of distilled water (W) or isotonic beverage (IB) on the hydration status in subjects living under these conditions. In a randomized crossover design, forty-nine healthy male subjects either consumed beverage or IB over a period of 8 h (8 h) in a controlled air-conditioned environment. Blood, urine, and saliva samples were collected at baseline and after 8 h...
March 7, 2017: Nutrients
https://www.readbyqxmd.com/read/28270594/aldosterone-does-not-alter-endothelin-b-receptor-signaling-in-the-inner-medullary-collecting-duct
#11
Nirupama Ramkumar, Deborah Stuart, Tianxin Yang, Donald E Kohan
Recent studies suggest that aldosterone-mediated sulfenic acid modification of the endothelin B receptor (ETB) promotes renal injury in an ischemia/reperfusion model through reduced ETB-stimulated nitric oxide production. Similarly, aldosterone inactivation of ETB signaling promotes pulmonary artery hypertension. Consequently, we asked whether aldosterone inhibits collecting duct ETB signaling; this could promote fluid retention since CD ETB exerts natriuretic and diuretic effects. A mouse inner medullary collecting duct cell line (IMCD3) was treated with aldosterone for 48 h followed by sarafotoxin-6c, an ETB-selective agonist, and extracellular signal-related kinase 1/2 (ERK) phosphorylation assessed...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28267999/extension-of-golay-s-plate-height-equation-from-laminar-to-turbulent-flow-i-theory
#12
Fabrice Gritti
The reduced plate height (RPH) equation of Golay derived in 1958 for open tubular columns (OTC) is extended from laminar to turbulent-like flow. The mass balance equation is solved under near-equilibrium conditions in the mobile phase for changing shapes of the velocity profile across the OTC diameter. The final expression of the general RPH equation is: [Formula: see text] where ν is the reduced linear velocity, k is the retention factor, Dm is the bulk diffusion coefficient in the mobile phase, Da¯ is the average axial dispersion coefficient, Dr¯ is the average radial dispersion coefficient, Ds is the diffusion coefficient of the analyte in the stationary film of thickness df, D is the OTC inner diameter, and n≥2 is a positive number controlling the shape of the flow profile (polynomial of degree n)...
February 24, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28261965/relationship-between-cytokine-levels-in-the-cerebrospinal-fluid-and-11c-pittsburgh-compound%C3%A2-b-retention-in-patients-with-mild-cognitive-impairment
#13
Yoshitake Abe, Noriyuki Kimura, Ryuichi Takahashi, Megumi Gotou, Ken Mizukami, Hirotatsu Uchida, Etsuro Matsubara
AIM: In the present study, we examined the relationship between cytokine levels in the cerebrospinal fluid (CSF) and (11) C-Pittsburgh compound B (PiB) retention in patients with mild cognitive impairment. METHODS: A total of 33 participants (12 men and 21 women; mean age 76.5 years) with mild cognitive impairment underwent neuropsychological assessments, PiB positron emission tomography and analysis of cytokine levels in the CSF. The CSF levels of 48 cytokines and growth factors were measured using multiplex immunoassays...
March 5, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28253022/a-sodium-drink-enhances-fluid-retention-during-3-hours-of-post-exercise-recovery-when-ingested-with-a-standard-meal
#14
Gethin H Evans, Jennifer Miller, Sophie Whiteley, Lewis J James
The purpose of this study was to examine the efficacy of water and a 50 mmol/L NaCl solution on post-exercise rehydration when a standard meal was consumed during rehydration. Eight healthy participants took part in two experimental trials during which they lost 1.5 ± 0.4 % of initial body mass via intermittent exercise in the heat. Participants then rehydrated over a 60 minute period with water or a 50 mmol/L NaCl solution in a volume equivalent to 150% of their body mass loss during exercise. In addition, a standard meal was ingested during this time which was equivalent to 30% of participants predicted daily energy expenditure...
March 2, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28244261/effect-of-beta-adrenergic-blockade-with-carvedilol-on-cachexia-in-severe-chronic-heart-failure-results-from-the-copernicus-trial
#15
Andrew L Clark, Andrew J S Coats, Henry Krum, Hugo A Katus, Paul Mohacsi, Damien Salekin, Melissa K Schultz, Milton Packer, Stefan D Anker
BACKGROUND: Cardiac cachexia frequently accompanies the progression of heart failure despite the use of effective therapies for left ventricular dysfunction. Activation of the sympathetic nervous system has been implicated in the pathogenesis of weight loss, but the effects of sympathetic antagonism on cachexia are not well defined. METHODS: We prospectively evaluated changes in body weight in 2289 patients with heart failure who had dyspnoea at rest or on minimal exertion and a left ventricular ejection fraction <25%...
February 27, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28242050/combination-of-partial-least-squares-regression-and-design-of-experiments-to-model-the-retention-of-pharmaceutical-compounds-in-supercritical-fluid-chromatography
#16
Bertyl Andri, Amandine Dispas, Roland Djang'Eing'a Marini, Philippe Hubert, Patrick Sassiat, Ramia Al Bakain, Didier Thiébaut, Jérôme Vial
This work presents a first attempt to establish a model of the retention behaviour for pharmaceutical compounds in gradient mode SFC. For this purpose, multivariate statistics were applied on the basis of data gathered with the Design of Experiment (DoE) methodology. It permitted to build optimally the experiments needed, and served as a basis for providing relevant physicochemical interpretation of the effects observed. Data gathered over a broad experimental domain enabled the establishment of well-fit linear models of the retention of the individual compounds in presence of methanol as co-solvent...
March 31, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28228622/a-case-of-hyperammonemia-with-obstructive-urinary-tract-infection-by-urease-producing-bacteria
#17
Toshiaki Goda, Kotaro Watanabe, Junya Kobayashi, Yasuharu Nagai, Nobuyuki Ohara, Daisuke Takahashi
A 79-year-old woman was admitted emergently for disturbance of consciousness. Her consciousness level was Japan coma scale 20, and she presented with hypermyotonia. Brain magnetic resonance imaging and cerebrospinal fluid examination showed normal findings. Her blood tests showed an increased ammonia level of 291 μg/dl with normal liver function. We catheterized the bladder for urinary retention. Eight hours after admission, the blood level of ammonia decreased to 57 μg/dl and the patient's consciousness level improved...
February 22, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28228293/cardiorenal-syndrome-type-4-a-study-of-cardiovascular-diseases-in-chronic-kidney-disease
#18
Suresh H, Arun B S, Venkatesh Moger, Mallikarjuna Swamy
INTRODUCTION: The heart and the kidneys are tightly interlinked with each other. So, primary disorder of one of these organs often results in the secondary dysfunction of other. Such interactions play a vital role in the pathogenesis of a clinical entity called cardio-renal syndrome (CRS). CRS type 4 refers to the development of cardiac failure in the patients with CKD. OBJECTIVES: To study the prevalence of various cardiac diseases in the patients with CKD and risk factors for it...
January 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28223322/eta-receptors-blockade-by-activating-etb-receptors-increases-vascular-permeability-and-induces-exaggerated-fluid-retention
#19
Magali Vercauteren, Frederic Trensz, Anne Pasquali, Christophe Cattaneo, Daniel S Strasser, Patrick Hess, Marc Iglarz, Martine Clozel
Endothelin receptor antagonists have been associated with fluid retention. It has been suggested that, of the two endothelin receptor subtypes, ETB receptors should not be blocked, because of their involvement in natriuresis and diuresis. Surprisingly, clinical data suggest that ETA-selective antagonists pose a greater risk of fluid overload than dual antagonists. The purpose of this study was to evaluate the contribution of each endothelin receptor to fluid retention and vascular permeability in rats. Sitaxentan and ambrisentan as ETA-selective antagonists, bosentan and macitentan as dual antagonists were used as representatives of each class, respectively...
February 21, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28221829/the-evolutionary-economics-of-embryonic-sac-fluids-in-squamate-reptiles
#20
Xavier Bonnet, Guy Naulleau, Richard Shine
The parchment-shelled eggs of squamate reptiles take up substantial water from the nest environment, enabling the conversion of yolk into neonatal tissue and buffering the embryo against the possibility of subsequent dry weather. During development, increasing amounts of water are stored in the embryonic sacs (i.e., membranes around the embryo: amnion, allantois, and chorion). The evolution of viviparity (prolonged uterine retention of developing embryos) means that embryonic-sac fluid storage now imposes a cost (increased maternal burdening), confers less benefit (because the mother buffers fetal water balance), and introduces a potential conflict among uterine siblings (for access to finite water supplies)...
March 2017: American Naturalist
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