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https://www.readbyqxmd.com/read/29686796/rapidly-progressive-dyspnea-in-gastrointestinal-stromal-tumor-gist-with-imatinib-cardiac-toxicity
#1
Adnan Asif Parvez Ghias, Shahzeem Bhayani, David J Gemmel, Sudershan K Garg
Gastrointestinal stromal tumors (GISTs) are rare and current estimates range from 4,000 to 6,000 number of GIST cases in the USA annually. Imatinib, a tyrosine kinase inhibitor, has shown a survival benefit in GISTs, and the presence of KIT mutation status is predictive of response. The current case discusses rapidly progressive dyspnea and heart failure in an elderly male with metastatic GIST who was started on imatinib. Although reported as a rare and sporadic side effect of imatinib, the current case illustrates rapidity and the clinical significance of cardiotoxicity, with onset at 2 weeks...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29677612/synthesis-characterization-and-working-mechanism-of-a-novel-sustained-release-type-fluid-loss-additive-for-seawater-cement-slurry
#2
Lei Cao, Jintang Guo, Jianhua Tian, Yang Xu, Miaomiao Hu, Chun Guo, Meiyu Wang, Jinjie Fan
Synthetic polymer fluid loss additive (FLA), an important type of admixture, was broadly applied in modern well cementation. However, the filter loss volume and fluidity of cement pastes containing polymer-FLA would deteriorate remarkably when sea water was used in mixing slurries instead of fresh water. In this study, a novel sustained-release-type fluid loss additive(S-FLA) was synthesized by means of anion-exchange intercalation reaction between an anionic type-copolymer and a calcium/aluminum type-Layered Double Hydroxide (Ca/Al-LDH)...
April 4, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29676120/-preparation-and-transdermal-permeation-of-triptolide-and-ferulic-acid-ethosomes-gel-in-vitro
#3
Ling Tao, Liang-Fei He, Yong-Mei Guan, Li-Hua Chen, Wei-Feng Zhu, Chen Jin, Lu Wu
The aim of this study was to prepare triptolide and ferulic acid ethosomes gel, investigate its transdermal permeation, and compare the results with ordinary gel and cream. Improved Franz diffusion cell method was used in the transdermal delivery experiment with rat abdominal skin as in vitro model. The receptor fluid at different time points was collected; ferulic acid concentration was determined by high performance liquid chromatography (HPLC) and triptolide concentration was determined by liquid chromatography-electrospray ionization mass spectrometry (LC-MS/MS)...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29669139/diuretic-or-sodium-restricted-diet-for-obstructive-sleep-apnea-a-randomized-trial
#4
Cintia Zappe Fiori, Denis Martinez, Carolina Caruccio Montanari, Pedro Lopez, Rodrigo Camargo, Lauren Sezerá, Sandro Cadaval Gonçalves, Flavio Danni Fuchs
Study Objectives: Interventions that decrease leg fluid retention reduce obstructive sleep apnea (OSA) severity in nonrandomized experiments. We aimed to investigate in a randomized trial the effect of interventions that reduce fluid volume on OSA severity. Methods: Men diagnosed with severe OSA were randomized to receive daily spironolactone 100 mg + furosemide 20 mg or nutritional counseling to sodium-restricted diet plus placebo pill or placebo pill. All participants underwent home sleep apnea testing at baseline and after 1 week follow-up...
April 1, 2018: Sleep
https://www.readbyqxmd.com/read/29665203/tolvaptan-alleviates-excessive-fluid-retention-of-nephrotic-diabetic-renal-failure-unresponsive-to-furosemide
#5
Tesshu Takada, Tsuguto Masaki, Ayako Hoshiyama, Takuya Toki, Yuji Kamata, Masayoshi Shichiri
Patients with diabetic nephropathy develop nephrotic syndrome, and may show limited response to conventional therapy. They often require earlier initiation of renal replacement therapy because they become refractory to diuretics, and experience excessive fluid retention. We aimed to investigate the efficacy of tolvaptan, an oral arginine vasopressin type 2 receptor antagonist, in a case series of 14 severe diabetic renal failure patients who were severely refractory to maximal doses of furosemide and had excessive fluid retention despite preserved cardiac function and residual renal function...
April 17, 2018: Nephrology
https://www.readbyqxmd.com/read/29659166/strategies-to-improve-tumor-penetration-of-nanomedicines-through-nanoparticle-design
#6
REVIEW
Ya-Ru Zhang, Run Lin, Hong-Jun Li, Wei-Ling He, Jin-Zhi Du, Jun Wang
Nanoparticles (NPs) have emerged as an effective means to deliver therapeutic drugs for cancer treatment, as they can preferentially accumulate at tumor site through the enhanced permeability and retention effect. Various forms of NPs including liposomes, polymeric micelles, and inorganic particles have been used for therapeutic applications. However, the therapeutic benefits of nanomedicines are suboptimal. Although many possible reasons may account for the compromised therapeutic efficacy, the inefficient tumor penetration can be a vital obstacle...
April 16, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/29655878/fluid-retention-aldosterone-excess-and-treatment-of-resistant-hypertension
#7
David A Calhoun
No abstract text is available yet for this article.
April 11, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29655877/endocrine-and-haemodynamic-changes-in-resistant-hypertension-and-blood-pressure-responses-to-spironolactone-or-amiloride-the-pathway-2-mechanisms-substudies
#8
Bryan Williams, Thomas M MacDonald, Steve V Morant, David J Webb, Peter Sever, Gordon T McInnes, Ian Ford, J Kennedy Cruickshank, Mark J Caulfield, Sandosh Padmanabhan, Isla S Mackenzie, Jackie Salsbury, Morris J Brown
BACKGROUND: In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did three substudies to assess the mechanisms underlying this superiority and the pathogenesis of resistant hypertension. METHODS: PATHWAY-2 was a randomised, double-blind crossover trial done at 14 UK primary and secondary care sites in 314 patients with resistant hypertension. Patients were given 12 weeks of once daily treatment with each of placebo, spironolactone 25-50 mg, bisoprolol 5-10 mg, and doxazosin 4-8 mg and the change in home systolic blood pressure was assessed as the primary outcome...
April 11, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29649771/systematic-forensic-toxicological-analysis-by-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-in-serum-and-comparison-to-gas-chromatography-mass-spectrometry
#9
Marcel Grapp, Christoph Kaufmann, Frank Streit, Lutz Binder
Comprehensive screening procedures for psychoactive agents in body fluids are an essential task in clinical and forensic toxicology. With the continuous emergence and adaption of new psychoactive substances (NPS) keeping a screening method up to date is challenging. To meet these demands, hyphenated high-resolution mass spectrometry has gained interest as extensive and expandable screening approach. Here we present a comprehensive method for systematic toxicological analysis of serum by liquid chromatography-quadrupole-time-of-flight mass spectrometry (LC-QTOF-MS) with data independent acquisition...
April 3, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29609854/residual-moisture-and-waterborne-pathogens-inside-flexible-endoscopes-evidence-from-a-multisite-study-of-endoscope-drying-effectiveness
#10
Cori L Ofstead, Otis L Heymann, Mariah R Quick, John E Eiland, Harry P Wetzler
BACKGROUND: Endoscopy-associated infection transmission is frequently linked to inadequate reprocessing. Residual organic material and moisture may foster biofilm development inside endoscopes. This study evaluated the effectiveness of endoscope drying and storage methods and assessed associations between retained moisture and contamination. METHODS: Endoscope reprocessing, drying, and storage practices were assessed at 3 hospitals. Researchers performed visual examinations and tests to detect fluid and contamination on patient-ready endoscopes...
March 30, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29609017/enhancing-predicted-fluoride-varnish-efficacy-and-post-treatment-compliance-by-means-of-calcium-containing-gummy-bears
#11
F Lippert, L Al Dehailan, G A Castiblanco, A A Tagelsir, C Buckley, G J Eckert
OBJECTIVES: This study determined whether consumption of calcium-containing gummies prior to fluoride varnish application enhances plaque fluoride retention and compliance with post-varnish application instructions. METHODS: The present study followed a multi-center, parallel, randomized, and laboratory analyst-blind design. Following IRB approval, parent consent and child assent, 44 subjects (7-12 years), were randomized to either gummy or no-gummy study groups...
March 30, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29606759/characterization-of-neem-azadirachta-indica-a-juss-seed-volatile-compounds-obtained-by-supercritical-carbon-dioxide-process
#12
R Swapna Sonale, K Ramalakshmi, K Udaya Sankar
Extraction process employing Supercritical fluid carbon dioxide (SCF) yields bioactive compounds near natural forms without any artifact formation. Neem seed was subjected to SCF at different temperatures and pressure conditions. These extracts were partitioned to separate volatile fraction and were analyzed by Gas Chromatography-Mass spectroscopy along with the volatiles extracted by the hydro-distillation method. Experimental results show that there is a significant effect of pressure and temperature on isolation of a number of volatile compounds as well as retention of biologically active compounds...
April 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29597125/the-anti-inflammatory-effect-of-exogenous-lactoferrin-on-breeding-induced-endometritis-in-susceptible-mares-when-administered-post-breeding-in-susceptible-mares
#13
C E Fedorka, K E Scoggin, Y L Boakari, N E Hoppe, E L Squires, B A Ball, M H T Troedsson
The deposition of semen into the uterus of the horse induces a transient innate immune response that lasts 24-36 h in the normal mare. There exists a subset of mares that are unable to resolve this inflammation in a timely manner, and are classified as susceptible to the disease of persistent breeding-induced endometritis (PBIE). Lactoferrin is a protein of interest as a potential therapeutic for this persistent inflammation due to its anti-inflammatory and bactericidal properties. The addition of human recombinant lactoferrin (hrLF) to the insemination dose was previously shown to suppress mRNA expression of the pro-inflammatory cytokine tumor necrosis factor (TNF)-α at 6 h after insemination, but no studies have shown the effect of lactoferrin when infused post-breeding...
March 22, 2018: Theriogenology
https://www.readbyqxmd.com/read/29589839/ppar%C3%AE-deacetylation-dissociates-thiazolidinedione-s-metabolic-benefits-from-its-adverse-effects
#14
Michael J Kraakman, Qiongming Liu, Jorge Postigo-Fernandez, Ruiping Ji, Ning Kon, Delfina Larrea, Maria Namwanje, Lihong Fan, Michelle Chan, Estela Area-Gomez, Wenxian Fu, Remi J Creusot, Li Qiang
Thiazolidinediones (TZDs) are PPARγ agonists with potent insulin-sensitizing effects. However, their use has been curtailed by significant adverse effects on weight, bone, heart, and hemodynamic balance. TZDs induce the deacetylation of PPARγ on K268 and K293 to cause the browning of white adipocytes. Here we showed that targeted PPARγ mutations resulting in constitutive deacetylation (K268R/K293R, 2KR) increased energy expenditure, and protected from visceral adiposity and diet-induced obesity by augmenting brown remodeling of white adipose tissues...
March 27, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29588430/an-engineered-complement-factor-h-construct-for-treatment-of-c3-glomerulopathy
#15
Yi Yang, Harriet Denton, Owen R Davies, Kate Smith-Jackson, Heather Kerr, Andrew P Herbert, Paul N Barlow, Matthew C Pickering, Kevin J Marchbank
Background C3 glomerulopathy (C3G) is associated with dysregulation of the alternative pathway of complement activation, and treatment options for C3G remain limited. Complement factor H (FH) is a potent regulator of the alternative pathway and might offer a solution, but the mass and complexity of FH makes generation of full-length FH far from trivial. We previously generated a mini-FH construct, with FH short consensus repeats 1-5 linked to repeats 18-20 (FH1-5^18-20 ), that was effective in experimental C3G...
March 27, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29580802/poly-butylene-terephthalate-based-novel-achiral-stationary-phase-investigated-under-supercritical-fluid-chromatography-conditions
#16
Kanji Nagai, Tohru Shibata, Satoshi Shinkura, Atsushi Ohnishi
Poly(butylene terephthalate) based novel stationary phase (SP), composed of planar aromatic phenyl group together with ester group monomer units, was designed for supercritical fluid chromatography (SFC) use. As expected from its structure, this phase shows planarity recognition of isomeric aromatics and closely similar compounds. Interestingly, for most analytes, the retention behavior of this SP is significantly distinct from that of the 2-ethylpyridine based SPs which is among the most well-known SFC dedicated phases...
March 17, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29573784/supercritical-fluid-chromatography-versus-high-performance-liquid-chromatography-for-enantiomeric-and-diastereoisomeric-separations-on-coated-polysaccharides-based-stationary-phases-application-to-dihydropyridone-derivatives
#17
Vanessa Hoguet, Julie Charton, Paul-Emile Hecquet, Chahinaze Lakhmi, Emmanuelle Lipka
For analytical applications, SFC has always remained in the shadow of LC. Analytical enantioseparation of eight dihydropyridone derivatives, was run in both High Performance Liquid Chromatography and Supercritical Fluid Chromatography. Four polysaccharide based chiral stationary phases namely amylose and cellulose tris(3, 5-dimethylphenylcarbamate), amylose tris((S)-α-phenylethylcarbamate) and cellulose tris(4-methylbenzoate) with four mobile phases consisted of either n-hexane/ethanol or propan-2-ol (80:20 v:v) or carbon dioxide/ethanol or propan-2-ol (80:20 v:v) mixtures were investigated under same operatory conditions (temperature and flow-rate)...
March 19, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29573646/evaluation-of-interleukin-1%C3%AE-level-and-oxidative-status-in-gingival-crevicular-fluid-during-rapid-maxillary-expansion
#18
Nur Ozel, Alev Aksoy, Fatma Yesim Kırzıoglu, Duygu Kumbul Doguc, Tutku Atış Aksoy
OBJECTIVES: The levels of interleukin-1β (IL-1β), nitric oxide (NO), total antioxidant capacity (TAC), and total oxidant status (TOS) in gingival crevicular fluid (GCF) were determined during rapid maxillary expansion (RME) treatment. MATERIALS AND METHODS: Fourteen patients (10-13 years old) were included. A modified hyrax appliance was used for the treatment. After periodontal parameters were recorded, GCF was collected from the first molars at each observation [T1:baseline:14 days after periodontal prophylaxis and instructions; T2:1 day later hyrax inserted, at passive position; T3:1 week later; after the first activation; T4:after 2 × 1/4 activation; T5:after 7 × 1/4 activation; T6:after 14 × 1/4 activation; T7:retention period on the 1 st month; and T8:retention period on the 3rd month]...
March 6, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29571843/identification-of-a-prospective-early-motor-progression-cluster-of-parkinson-s-disease-data-from-the-ppmi-study
#19
George D Vavougios, Triantafyllos Doskas, Constantinos Kormas, Karen A Krogfelt, Sotirios G Zarogiannis, Leonidas Stefanis
AIM: The aim of our study is to phenotype PD motor progression, and to detect whether serum, cerebrospinal fluid (CSF), neuroimaging biomarkers and neuropsychological measures characterize PD motor progression phenotypes. METHODS: We defined motor progression as a difference of at least one point in the Hoehn & Yahr (H&Y) scale between the baseline (Visit 0, V0), 12 months (Visit 04, V04) and 36 months (Visit 08, V08) milestones of the Progression Markers Initiative (PPMI) study...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29571060/hypertrophic-spinal-pachymeningitis-associated-with-human-t-cell-lymphotrophic-virus-1-infection-and-sjogren-s-syndrome-a-case-report-and-brief-literature-review
#20
Costansia A Bureta, Masahiko Abematsu, Hiroyuki Tominaga, Yoshinobu Saitoh, Ichiro Kawamura, Satoshi Nagano, Takao Setoguchi, Yasuhiro Ishidou, Takuya Yamamoto, Setsuro Komiya
INTRODUCTION: Reports of hypertrophic spinal pachymeningitis associated with human T-cell lymphotrophic virus-1 (HTLV-1) infection and Sjogren's syndrome in the English literature are still very rare. PRESENTATION OF CASE: We hereby present a case of a 78-year-old female with a history of lower extremity weakness after a fall, which fully resolved after conservative treatment. However, the symptoms recurred 4 years later, and the patient became unable to walk. The patient had no superficial or deep sensation below the level of T9, and she also had urinary retention...
March 15, 2018: International Journal of Surgery Case Reports
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