Lotte Boxhoorn, Sven M van Dijk, Janneke van Grinsven, Robert C Verdonk, Marja A Boermeester, Thomas L Bollen, Stefan A W Bouwense, Marco J Bruno, Vincent C Cappendijk, Cornelis H C Dejong, Peter van Duijvendijk, Casper H J van Eijck, Paul Fockens, Michiel F G Francken, Harry van Goor, Muhammed Hadithi, Nora D L Hallensleben, Jan Willem Haveman, Maarten A J M Jacobs, Jeroen M Jansen, Marnix P M Kop, Krijn P van Lienden, Eric R Manusama, J Sven D Mieog, I Quintus Molenaar, Vincent B Nieuwenhuijs, Alexander C Poen, Jan-Werner Poley, Marcel van de Poll, Rutger Quispel, Tessa E H Römkens, Matthijs P Schwartz, Tom C Seerden, Martijn W J Stommel, Jan Willem A Straathof, Hester C Timmerhuis, Niels G Venneman, Rogier P Voermans, Wim van de Vrie, Ben J Witteman, Marcel G W Dijkgraaf, Hjalmar C van Santvoort, Marc G Besselink
BACKGROUND: Infected necrotizing pancreatitis is a potentially lethal disease that is treated with the use of a step-up approach, with catheter drainage often delayed until the infected necrosis is encapsulated. Whether outcomes could be improved by earlier catheter drainage is unknown. METHODS: We conducted a multicenter, randomized superiority trial involving patients with infected necrotizing pancreatitis, in which we compared immediate drainage within 24 hours after randomization once infected necrosis was diagnosed with drainage that was postponed until the stage of walled-off necrosis was reached...
October 7, 2021: New England Journal of Medicine