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magnesium sulphate

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https://www.readbyqxmd.com/read/28214095/whether-preventive-low-dose-magnesium-sulphate-infusion-has-an-influence-on-postoperative-pain-perception-and-the-level-of-serum-beta-endorphin-throughout-the-total-abdominal-hysterectomy
#1
K Haryalchi, M Abedinzade, K Khanaki, M M Ghanaie, F M Zadeh
OBJECTIVE: Due to the known role of preventive low dose magnesium sulphate on postoperative pain management, in this randomized, double-blinded, placebo-controlled study, we tried to investigate the possible relationship between low dose intra-operative magnesium sulphate infusion, postoperative analgesia and the level of serum beta-endorphin during total abdominal hysterectomy under general anesthesia. METHODS: Forty women undergoing total abdominal hysterectomy were randomly allocated into 2 groups (20 in each arm)...
February 14, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28194635/using-the-slug-mucosal-irritation-assay-to-investigate-the-tolerability-of-tablet-excipients-on-human-skin-in-the-context-of-the-use-of-a-nipple-shield-delivery-system
#2
Richard Kendall, Joke Lenoir, Stephen Gerrard, Rebekah L Scheuerle, Nigel K H Slater, Catherine Tuleu
PURPOSE: Neonates are particularly challenging to treat. A novel patented drug delivery device containing a rapidly disintegrating tablet held within a modified nipple shield (NSDS) was designed to deliver medication to infants during breastfeeding. However concerns exist around dermatological nipple tolerability with no pharmaceutical safety assessment guidance to study local tissue tolerance of the nipple and the areola. This is the first Slug Mucosal Irritation (SMI) study to evaluate irritancy potential of GRAS excipients commonly used to manufacture rapidly disintegrating immediate release solid oral dosage form METHODS: Zinc sulphate selected as the antidiarrheal model drug that reduces infant mortality, was blended with functional excipients at traditional levels [microcrystalline cellulose, sodium starch glycolate, croscarmellose sodium, magnesium stearate]...
February 13, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28166926/-neuroprotection-for-preterm-infants-with-antenatal-magnesium-sulphate
#3
S Marret, P-Y Ancel
OBJECTIVE: To evaluate in preterm born children the neuroprotective benefits and the risks, at short- and long-term outcome, of the antenatal administration of magnesium sulphate (MgSO4) in women at imminent risk of preterm delivery. MATERIAL AND METHODS: Computer databases Medline, the Cochrane Library and the recommendations of various international scientific societies. RESULTS: Given the demonstrated benefit of antenatal MgSO4 intravenous administration on the reduction of cerebral palsy rates and the improvement of motor development in children born preterm, it is recommended for all women whose imminent delivery is expected or programmed before 32 weeks of gestation (WG) (grade A)...
December 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/28153353/the-effect-of-nebulised-magnesium-sulphate-in-the-management-of-childhood-moderate-asthma-exacerbations-as-adjuvant-treatment
#4
S Turker, M Dogru, F Yildiz, S Bozkaya Yilmaz
BACKGROUND: After the bronchodilator effect of magnesium was shown, the use of magnesium in treatment of asthma exacerbations became common. With the results of recent studies, the use of intravenous magnesium in severe asthma exacerbations took its place. We aimed to examine the effects of adding isotonic magnesium sulphate instead of isotonic saline into nebulised salbutamol on the Modified Pulmonary Index Score (MPIS) and the hospitalisation rate in moderate asthma exacerbations. METHODS: Our study population included 100 children age between 3 and 15 years with asthma admitted to emergency department due to moderate asthma exacerbations...
January 30, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28128686/the-dissolution-kinetics-of-industrial-brine-sludge-wastes-from-a-chlor-alkali-industry-as-a-sorbent-for-wet-flue-gas-desulphurisation-fgd
#5
N Masilela, L Lerotholi, T Seodigeng, H Rutto
: The disposal of industrial brine sludge waste (IBSW) in chlor-alkali plants can be avoided by utilization of IBSW as a sorbent in wet flue gas desulphurization. The shrinking core model was used to determine the dissolution kinetics of IBSW which is a vital step in wet FGD. The effect of solid to liquid ratio (m/v), temperature, pH, particle size and stirring speed on the conversion and dissolution rate constant are determined. The conversion and dissolution rate constant decreases as the pH, particle size and solid to liquid ratio is increased and increases as the temperature, concentration of acid and stirring speed is increased...
January 27, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28099570/variation-of-the-interphase-heterochromatin-in-artemia-crustacea-anostraca-of-the-americas-is-related-to-changes-in-nuclear-size-and-ionic-composition-of-hipersaline-habitats
#6
M Parraguez, G Gajardo
The populations of Artemia (or brine shrimp) from the Americas exhibit a wide variation in the amount of interphase heterochromatin. There is interest in understanding how this variation affects different parameters, from the cellular to the organismal levels. This should help to clarify the ability of this organism to tolerate brine habitats regularly subject to strong abiotic changes. In this study, we assessed the amount of interphase heterochromatin per nucleus based on chromocenter number (N-CHR) and relative area of chromocenter (R-CHR) in two species of Artemia, A...
January 12, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28077538/magnesium-sulphate-attenuates-acute-postoperative-pain-and-increased-pain-intensity-after-surgical-injury-in-staged-bilateral-total-knee-arthroplasty-a-randomized-double-blinded-placebo-controlled-trial
#7
H-J Shin, E-Y Kim, H-S Na, T K Kim, M-H Kim, S-H Do
BACKGROUND: We evaluated the effect of magnesium sulphate on increased pain in 44 patients undergoing staged bilateral total knee arthroplasty (TKA). METHODS: The magnesium group (n=22) and the control group (n=22) received magnesium sulphate and isotonic saline, respectively, throughout the surgery. Postoperative pain (visual analogue scale, VAS) at rest and the amounts of patient-controlled analgesia (PCA, fentanyl) and rescue analgesia (ketoprofen) administered during the first 48 h were compared between the two groups and within each group between the first and second TKA...
October 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28050451/choriocarcinoma-in-ongoing-pregnancy-presenting-with-intracranial-metastasis
#8
Sujata Siwatch, Vanita Suri, Pooja Sikka, Neelam Aggarwal, Seema Chopra
Choriocarcinoma presents usually as persistent trophoblastic disease, with prognosis worsening with duration from antecedent pregnancy. We present a unique case of a woman with choriocarcinoma who presented in the third trimester of pregnancy with eclampsia. She was managed with magnesium sulphate and underwent a caesarean section. However, she developed seizures in the post-partum period that were further investigated and attributed to intracranial metastatic lesions of Gestational Trophoblastic Neoplasia (GTN)...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28017170/effects-of-lidocaine-and-magnesium-sulfate-in-attenuating-hemodynamic-response-to-tracheal-intubation-single-center-prospective-double-blind-randomized-study
#9
Fabricio Tavares Mendonça, Lucas Macedo da Graça Medeiros de Queiroz, Cristina Carvalho Rolim Guimarães, Alexandre Cordeiro Duarte Xavier
BACKGROUND AND OBJECTIVES: Hemodynamic response to airway stimuli is a common phenomenon and its management is important to reduce the systemic repercussions. The objective of this study is to compare the efficacy of intravenous magnesium sulfate versus lidocaine on this reflex hemodynamics after laryngoscopy and tracheal intubation. METHODS: This single-center, prospective, double-blind, randomized study evaluated 56 patients ASA 1 or 2, aged 18-65 years, scheduled for elective surgeries under general anesthesia with intubation...
January 2017: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/28011430/carbon-dioxide-sequestration-using-nahso4-and-naoh-a-dissolution-and-carbonation-optimisation-study
#10
Aimaro Sanna, Luc Steel, M Mercedes Maroto-Valer
The use of NaHSO4 to leach out Mg fromlizardite-rich serpentinite (in form of MgSO4) and the carbonation of CO2 (captured in form of Na2CO3 using NaOH) to form MgCO3 and Na2SO4 was investigated. Unlike ammonium sulphate, sodium sulphate can be separated via precipitation during the recycling step avoiding energy intensive evaporation process required in NH4-based processes. To determine the effectiveness of the NaHSO4/NaOH process when applied to lizardite, the optimisation of the dissolution and carbonation steps were performed using a UK lizardite-rich serpentine...
March 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/27998859/-effect-of-magnesium-sulphate-infusion-on-emergence-agitation-in-patients-undergoing-esophageal-carcinoma-with-general-anesthesia-a-randomized-double-blind-controlled-trial
#11
Min Xie, Xiang-Kui Li, Jie Chen
OBJECTIVE: To evaluate the safety and effectiveness of magnesium sulphate for reducing the incidence of the emergence agitation in patients undergoing surgery for esophageal carcinoma with general anesthesia. METHODS: This randomized, double-blind, controlled clinical trial was conducted in patients undergoing elective radical resection of esophageal carcinoma in Sichuan Provincial People's Hospital between October, 2015 and March, 2016. The patients underwent surgeries under general intravenous anesthesia, and after anesthesia induction, the patients were infused with magnesium sulphate at the rate of 0...
December 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27939482/magnesium-sulphate-prevents-lipopolysaccharide-induced-cell-death-in-an-in-vitro-model-of-the-human-placenta
#12
Rachel D Williamson, Cathal McCarthy, Louise C Kenny, Gerard W O'Keeffe
OBJECTIVES: To determine if magnesium sulphate (MgSO4) prevents lipopolysaccharide (LPS)-induced cell death in an in vitro model of the human placenta. STUDY DESIGN: BeWo choriocarcinoma cells were treated with increasing concentrations of LPS (10-1000ng/ml) and MgSO4 ranging from 1 mM to 100 mM for 24 or 48h. For co-treatments, cells were pre-treated with 1mM MgSO4 for 1h and 200ng/ml LPS was then added for the remaining 48h. To assess viability an MTT assay was carried out along with nuclear staining to assess pyknotic nuclei...
October 2016: Pregnancy Hypertension
https://www.readbyqxmd.com/read/27892433/efficacy-of-prophylactic-b-lynch-suture-during-lower-segment-caesarian-section-in-high-risk-patients-for-atonic-postpartum-haemorrhage
#13
M Vijayasree
Background Postpartum Haemorrhage causes significant maternal mortality and morbidity all over the world. Active management of the third stage of labour with oxytocics is come into practice. If postpartum haemorrhage is anticipated conservative surgical procedures like B-lynch suture is being applied. Objective To evaluate the effect of elective B-Lynch suture in preventing atonic postpartum haemorrhage during emergency caesarian section with high risk factors for atonicity. Method Forty antenatal women undergoing emergency caesarean section with risk factors for atony of the uterus were selected in our study...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27885772/clinical-practice-patterns-on-the-use-of-magnesium-sulphate-for-treatment-of-pre-eclampsia-and-eclampsia-a-multi-country-survey
#14
Q Long, O T Oladapo, S Leathersich, J P Vogel, G Carroli, P Lumbiganon, Z Qureshi, A M Gülmezoglu
OBJECTIVE: To characterise the current clinical practice patterns regarding the use of magnesium sulphate (MgSO4 ) for eclampsia prevention and treatment in a multi-country network of health facilities and compare with international recommendations. DESIGN: Cross-sectional survey. SETTING: A total of 147 health facilities in 15 countries across Africa, Latin America and Asia. POPULATION: Heads of obstetric departments or maternity units...
November 24, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27830959/neonatal-hypoxic-ischemic-encephalopathy-an-update-on-disease-pathogenesis-and-treatment
#15
Edibe Pembegül Yıldız, Barış Ekici, Burak Tatlı
Hypoxic ischemic encephalopathy (HIE) is the most important reason for morbidity and mortality in term-born infants. Understanding pathophysiology of the brain damage is essential for the early detection of patients with high risk for HIE and development of strategies for their treatments. Areas covered: This review discusses pathophysiology of the neonatal HIE and its treatment options, including hypothermia, melatonin, allopurinol, topiramate, erythropoietin, N-acetylcyctein, magnesium sulphate and xenon...
November 23, 2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27830597/is-there-a-place-for-nebulised-magnesium-sulphate-in-the-management-of-asthma
#16
REVIEW
Jonathan Lyons
Intravenous magnesium sulphate (MgSO4) is an accepted part of the pharmacological management of patients with asthma. There is conflicting information, however, on whether its nebulised form is beneficial. This article describes a case study in which a patient was given intravenous MgSO4. It was suggested by a medical consultant that she could have been given nebulised MgSO4, so a literature review was undertaken to examine its efficacy. The results suggest there is no evidence to support the use of nebulised MgSO4 in the management of patients with asthma...
November 10, 2016: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/27821003/nebulised-magnesium-sulphate-in-the-management-of-asthma
#17
(no author information available yet)
While the use of intravenous magnesium sulphate (MgSO4) is an accepted part of the pharmacological management of patients with asthma, there is conflicting information about whether it is beneficial in its nebulised form.
November 8, 2016: Nursing Children and Young People
https://www.readbyqxmd.com/read/27812057/preventive-role-of-magnesium-sulphate-on-dexamethasone-induced-testicular-injury-in-albino-rats
#18
Hemant Kumar, Aisha Qamar
OBJECTIVE: To evaluate the protection provided by magnesium sulphate on corticosteroid-induced testicular injury in albino rats. METHODS: This experimental study was conducted at Jinnah Postgraduate Medical Centre, Karachi, from August 1 to 20, 2012, and comprised albino rats. About 90-120 days old and weighing 200-230 gm. They were divided into 3 groups. Group A comprised controls, Group B animals were administered dexamethasone 4mg/kg body weight per day intra-peritoneally, and Group C animals were given magnesium sulphate 20mg/kg body weight per day intramuscularly, with dexamethasone at same dose as in Group B...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27809968/inhomogeneity-of-the-density-of-parascaris-spp-eggs-in-faeces-of-individual-foals-and-the-use-of-hypothesis-testing-for-treatment-decision-making
#19
E J A Wilkes, A Cowling, R G Woodgate, K J Hughes
Faecal egg counts (FEC) are used widely for monitoring of parasite infection in animals, treatment decision-making and estimation of anthelmintic efficacy. When a single count or sample mean is used as a point estimate of the expectation of the egg distribution over some time interval, the variability in the egg density is not accounted for. Although variability, including quantifying sources, of egg count data has been described, the spatiotemporal distribution of nematode eggs in faeces is not well understood...
October 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27792736/micronized-organic-magnesium-salts-enhance-opioid-analgesia-in-rats
#20
Magdalena Bujalska-Zadrożny, Kamila Kulik, Michał Ordak, Małgorzata Sasinowska-Motyl, Emilia Gąsińska, Anna de Corde, Agnieszka Kowalczyk, Mariusz Sacharczuk, Marek Naruszewicz
PURPOSE: As previously reported, magnesium sulphate administered parenterally significantly increased an opioid antinociception in different kinds of pain. Since the typical form of magnesium salts are poorly and slowly absorbed from the gastrointestinal tract we examined whether their micronized form could increase opioids induced antinociception. METHODS: In behavioural studies on rats morphine, tramadol and oxycodone together with magnesium (lactate dihydrate, hydroaspartate, chloride) in micronized (particles of size D90 < 50 μm) and conventional forms were used...
2016: PloS One
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