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magnesium sulphate

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https://www.readbyqxmd.com/read/27892433/efficacy-of-prophylactic-b-lynch-suture-during-lower-segment-caesarian-section-in-high-risk-patients-for-atonic-postpartum-haemorrhage
#1
M Vijayasree
Background Postpartum Haemorrhage causes significant maternal mortality and morbidity all over the world. Active management of the third stage of labour with oxytocics is come into practice. If postpartum haemorrhage is anticipated conservative surgical procedures like B-lynch suture is being applied. Objective To evaluate the effect of elective B-Lynch suture in preventing atonic postpartum haemorrhage during emergency caesarian section with high risk factors for atonicity. Method Forty antenatal women undergoing emergency caesarean section with risk factors for atony of the uterus were selected in our study...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27885772/clinical-practice-patterns-on-the-use-of-magnesium-sulphate-for-treatment-of-pre-eclampsia-and-eclampsia-a-multi-country-survey
#2
Q Long, O T Oladapo, S Leathersich, J P Vogel, G Carroli, P Lumbiganon, Z Qureshi, A M Gülmezoglu
OBJECTIVE: To characterise the current clinical practice patterns regarding the use of magnesium sulphate (MgSO4 ) for eclampsia prevention and treatment in a multi-country network of health facilities and compare with international recommendations. DESIGN: Cross-sectional survey. SETTING: A total of 147 health facilities in 15 countries across Africa, Latin America and Asia. POPULATION: Heads of obstetric departments or maternity units...
November 24, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27830959/neonatal-hypoxic-ischemic-encephalopathy-an-update-on-disease-pathogenesis-and-treatment
#3
Edibe Pembegül Yıldız, Barış Ekici, Burak Tatlı
Hypoxic ischemic encephalopathy (HIE) is the most important reason for morbidity and mortality in term-born infants. Understanding pathophysiology of the brain damage is essential for the early detection of patients with high risk for HIE and development of strategies for their treatments. Areas covered: This review discusses pathophysiology of the neonatal HIE and its treatment options, including hypothermia, melatonin, allopurinol, topiramate, erythropoietin, N-acetylcyctein, magnesium sulphate and xenon...
November 10, 2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27830597/is-there-a-place-for-nebulised-magnesium-sulphate-in-the-management-of-asthma
#4
Jonathan Lyons
Intravenous magnesium sulphate (MgSO4) is an accepted part of the pharmacological management of patients with asthma. There is conflicting information, however, on whether its nebulised form is beneficial. This article describes a case study in which a patient was given intravenous MgSO4. It was suggested by a medical consultant that she could have been given nebulised MgSO4, so a literature review was undertaken to examine its efficacy. The results suggest there is no evidence to support the use of nebulised MgSO4 in the management of patients with asthma...
November 10, 2016: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/27821003/nebulised-magnesium-sulphate-in-the-management-of-asthma
#5
(no author information available yet)
While the use of intravenous magnesium sulphate (MgSO4) is an accepted part of the pharmacological management of patients with asthma, there is conflicting information about whether it is beneficial in its nebulised form.
November 8, 2016: Nursing Children and Young People
https://www.readbyqxmd.com/read/27812057/preventive-role-of-magnesium-sulphate-on-dexamethasone-induced-testicular-injury-in-albino-rats
#6
Hemant Kumar, Aisha Qamar
OBJECTIVE: To evaluate the protection provided by magnesium sulphate on corticosteroid-induced testicular injury in albino rats. METHODS: This experimental study was conducted at Jinnah Postgraduate Medical Centre, Karachi, from August 1 to 20, 2012, and comprised albino rats. About 90-120 days old and weighing 200-230 gm. They were divided into 3 groups. Group A comprised controls, Group B animals were administered dexamethasone 4mg/kg body weight per day intra-peritoneally, and Group C animals were given magnesium sulphate 20mg/kg body weight per day intramuscularly, with dexamethasone at same dose as in Group B...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27809968/inhomogeneity-of-the-density-of-parascaris-spp-eggs-in-faeces-of-individual-foals-and-the-use-of-hypothesis-testing-for-treatment-decision-making
#7
E J A Wilkes, A Cowling, R G Woodgate, K J Hughes
Faecal egg counts (FEC) are used widely for monitoring of parasite infection in animals, treatment decision-making and estimation of anthelmintic efficacy. When a single count or sample mean is used as a point estimate of the expectation of the egg distribution over some time interval, the variability in the egg density is not accounted for. Although variability, including quantifying sources, of egg count data has been described, the spatiotemporal distribution of nematode eggs in faeces is not well understood...
October 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27792736/micronized-organic-magnesium-salts-enhance-opioid-analgesia-in-rats
#8
Magdalena Bujalska-Zadrożny, Kamila Kulik, Michał Ordak, Małgorzata Sasinowska-Motyl, Emilia Gąsińska, Anna de Corde, Agnieszka Kowalczyk, Mariusz Sacharczuk, Marek Naruszewicz
PURPOSE: As previously reported, magnesium sulphate administered parenterally significantly increased an opioid antinociception in different kinds of pain. Since the typical form of magnesium salts are poorly and slowly absorbed from the gastrointestinal tract we examined whether their micronized form could increase opioids induced antinociception. METHODS: In behavioural studies on rats morphine, tramadol and oxycodone together with magnesium (lactate dihydrate, hydroaspartate, chloride) in micronized (particles of size D90 < 50 μm) and conventional forms were used...
2016: PloS One
https://www.readbyqxmd.com/read/27787936/magnesium-sulphate-for-postoperative-complications-in-children-undergoing-tonsillectomies-a-systematic-review-and-meta-analysis
#9
Xie Min, L I Xiang-Kui, Peng Yu
OBJECTIVE: Previous systematical reviews showed that systemic magnesium decreased postoperative pain and reduced morphine use without any reported serious adverse effects in adults. However studies in children yielded different results. So we conducted a systematic review to evaluate the impact of magnesium sulphate on postoperative complications in Children undergoing tonsillectomies. METHODS: The PubMed, EMbase via OVID, CENTRAL, WHO ICTRP were searched to identify randomized controlled trials (RCTs) that addressed the effect of magnesium for postoperative pain, agitation and complications in children undergoing tonsillectomies...
September 8, 2016: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/27761040/a-comparison-of-intraperitoneal-bupivacaine-tramadol-with-bupivacaine-magnesium-sulphate-for-pain-relief-after-laparoscopic-cholecystectomy-a-prospective-randomised-study
#10
Anurag Yadava, Sunil K Rajput, Sarika Katiyar, Rajnish K Jain
BACKGROUND AND AIMS: In laparoscopic surgeries, intraperitoneal instillation of local anaesthetics and opioids is gaining popularity, for better pain relief. This study compared the quality and duration of post-operative analgesia using intraperitoneal tramadol plus bupivacaine (TB) or magnesium plus bupivacaine (MB). METHODS: In this study, 186 patients undergoing laparoscopic cholecystectomy were randomly divided into two groups: group TB received intraperitoneal tramadol with bupivacaine and group MB received intraperitoneal magnesium sulphate (MgSO4) with bupivacaine...
October 2016: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/27748058/review-article-role-of-magnesium-sulphate-in-the-management-of-irukandji-syndrome-a-systematic-review
#11
John Rathbone, Richard Franklin, Clinton Gibbs, David Williams
Signs of Irukandji syndrome (IS) suggest an underlying catecholamine storm with research demonstrating that Carukia barnesi venom causes a significant rise in adrenaline/noradrenaline serum levels. A systematic review was undertaken to ascertain the current evidence in treating IS with magnesium salts. A literature search was conducted using Scopus, Medline and ScienceDirect. Further articles were discarded via title description and/or abstract details. The remaining were read in full, and those identified as not having sufficient information regarding magnesium and patient outcomes were removed...
October 17, 2016: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/27722931/earthworm-comet-assay-for-assessing-the-risk-of-weathered-petroleum-hydrocarbon-contaminated-soils-need-to-look-further-than-target-contaminants
#12
Kavitha Ramadass, Thavamani Palanisami, Euan Smith, Srinithi Mayilswami, Mallavarapu Megharaj, Ravi Naidu
Earthworm toxicity assays contribute to ecological risk assessment and consequently standard toxicological endpoints, such as mortality and reproduction, are regularly estimated. These endpoints are not enough to better understand the mechanism of toxic pollutants. We employed an additional endpoint in the earthworm Eisenia andrei to estimate the pollutant-induced stress. In this study, comet assay was used as an additional endpoint to evaluate the genotoxicity of weathered hydrocarbon contaminated soils containing 520 to 1450 mg hydrocarbons kg(-1) soil...
October 8, 2016: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27720093/magnocaine-physical-compatibility-and-chemical-stability-of-magnesium-sulphate-and-lidocaine-hydrochloride-in-prefilled-syringes
#13
Sara Houlihan, Diane Decarie, Cindy Benes, Richard Cleve, Marianne Vidler, Laura A Magee, Mary H H Ensom, Peter von Dadelszen
OBJECTIVE: To evaluate the physical compatibility and chemical stability of mixtures of magnesium sulphate and lidocaine in order to determine the feasibility of manufacturing a prefilled syringe combining these two drugs for use as an intramuscular (IM) loading dose for eclampsia prevention and/or treatment. This ready-to-use mixture will provide a more tolerable and accessible route of administration appropriate for widespread use. METHODS: Physical compatibility (pH, colour, and formation of precipitate) and chemical stability (maintaining > 90% of initial concentrations) of mixtures of MgSO4, using both commercially available MgSO4 (50%) and MgSO4 reconstituted from salt (61%), with lidocaine hydrochloride (2%) were evaluated every 14 days over six months...
October 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/27719673/health-care-provider-knowledge-and-routine-management-of-pre-eclampsia-in-pakistan
#14
Sana Sheikh, Rahat Najam Qureshi, Asif Raza Khowaja, Rehana Salam, Marianne Vidler, Diane Sawchuck, Peter von Dadelszen, Shujat Zaidi, Zulfiqar Bhutta
BACKGROUND: Maternal mortality ratio is 276 per 100,000 live births in Pakistan. Eclampsia is responsible for one in every ten maternal deaths despite the fact that management of this disease is inexpensive and has been available for decades. Many studies have shown that health care providers in low and middle-income countries have limited training to manage patients with eclampsia. Hence, we aimed to explore the knowledge of different cadres of health care providers regarding aetiology, diagnosis and treatment of pre-eclampsia and eclampsia and current management practices...
September 30, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27612700/porous-magnesium-loaded-with-gentamicin-sulphate-and-in-vitro-release-behavior
#15
Qiuyan Li, Guofeng Jiang, Dong Wang, Huang Wang, Liang Ding, Guo He
Our aim was to develop a biocompatible bone repair material that has the advantage of preventing postoperative infections. Finally, the porous magnesium (p-Mg) loaded with gentamicin sulphate (GS-loaded Mg-G) was fabricated. The GS release behavior of the GS-loaded Mg-G in phosphate buffer saline (PBS) was investigated. The effective release time of GS reached to 14days. In addition, the effects of porosity and pore diameter of p-Mg on the GS release behavior of the GS-loaded Mg-G were studied. In the initial burst release stage, the GS release rate of the GS-loaded Mg-G increased with the increasing porosity or the increasing pore diameter of p-Mg...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27612025/tetanus-in-new-zealand-children-intensive-care-management-of-a-vaccine-preventable-disease
#16
Sophie Ch Wen, Catherine Webb, Fiona Miles, Elizabeth Wilson
AIM: To review management of children admitted with tetanus to Starship Children's Hospital from 2000 to 2013. METHODS: Retrospective chart review of children aged 0-15 years admitted to Starship Children's Hospital with tetanus from 2000 to 2013. Follow-up of immunisation status was via the National Immunisation Register and/or phone contact with patient's primary health care provider. RESULTS: Four cases of tetanus occurred, all in unimmunised children...
September 9, 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27601742/comparative-efficacy-of-ropivacaine-and-levobupivacaine-in-combined-femoral-and-lateral-femoral-cutaneous-nerve-block-with-adjuvant-magnesium-for-post-operative-analgesia
#17
Prakash Khairnar, Munisha Agarwal, Uttam Chandra Verma, Rakesh Kumar
BACKGROUND AND AIMS: Patients with burns may require multiple surgeries, but poor general condition and underlying protein energy malnutrition make them unsuitable candidates for general or spinal anaesthesia. This study evaluated the role of magnesium sulphate as an adjuvant with levobupivacaine and ropivacaine used in combined femoral and lateral femoral cutaneous nerve (LFCN) blocks in burn patients with relative sparing of thigh portion. METHODS: This prospective, randomised, double-blind study included 54 adult patients of 18-65 years age, undergoing split-thickness skin graft harvest from the thigh, allotted to three equal groups of 18 each...
August 2016: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/27545716/preventing-newborn-deaths-due-to-prematurity
#18
REVIEW
Kishwar Azad, Jiji Mathews
Preterm births (PTBs), defined as births before 37 weeks of gestation account for the majority of deaths in the newborn period. Prediction and prevention of PTB is challenging. A history of preterm labour or second trimester losses and accurate measurement of cervical length help to identify women who would benefit from progesterone and cerclage. Fibronectin estimation in the cervicovaginal secretions of a symptomatic woman with an undilated cervix can predict PTB within 10 days of testing. Antibiotics should be given to women with preterm prelabour rupture of membranes but tocolysis has a limited role in the management of preterm labour...
October 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27499789/antidiarrhoeal-assessment-of-hydroalcoholic-and-hexane-extracts-of-dracocephalum-kotschyi-boiss-and-apigenin-in-mice
#19
Hassan Sadraei, Gholamreza Asghari, Farzaneh Shahverdi
Dracocephalum kotschyi Boiss, a member of Labiatae family, is a native plant to Iran, which has been reported to have immunomodulatory, antihyperlipidemic and antispasmodic activities. The objective of this research was to study the antispasmodic and antidiarrhoeal activities of hydroalcoholic and hexane extracts of D. kotschyi in mice. Furthermore, the antidiarrhoeal and antispasmodic effect of apigenin, a flavonoid constituent of D. kotschyi, was also studied. Hydroalcoholic and hexane extracts were obtained from aerial part of D...
May 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27492552/the-burden-of-maternal-morbidity-and-mortality-attributable-to-hypertensive-disorders-in-pregnancy-a-prospective-cohort-study-from-uganda
#20
Annettee Nakimuli, Sarah Nakubulwa, Othman Kakaire, Michael Odongo Osinde, Scovia Nalugo Mbalinda, Nelson Kakande, Rose Chalo Nabirye, Dan Kabonge Kaye
BACKGROUND: Hypertensive disorders of pregnancy are a major cause of morbidity and mortality. The objective was to estimate the disease burden attributable to hypertensive disorders of pregnancy in two referral hospitals in Uganda. METHODS: Through a prospective cohort study conducted in Jinja and Mulago hospitals in Uganda from March 1, 2013 and February 28, 2014, hypertension-related cases were analyzed. Maternal near miss cases were defined according to the WHO criteria...
2016: BMC Pregnancy and Childbirth
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