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https://www.readbyqxmd.com/read/28532559/towards-a-molecular-classification-of-pulmonary-sarcomatoid-carcinomas
#1
EDITORIAL
Aaron S Mansfield, Anja C Roden, Jennifer M Boland
No abstract text is available yet for this article.
June 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28532546/-a-case-report-of-pulmonary-sarcomatoid-carcinoma-with-alk-rearrangement
#2
Yehong Miao, Lin Ling, Xiuqin Zhang, Jian'an Huang
No abstract text is available yet for this article.
May 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28529586/immunohistochemical-analysis-of-nanog-expression-and-epithelial-mesenchymal-transition-in-pulmonary-sarcomatoid-carcinoma
#3
Takeshi Tamaki, Toshiki Shimizu, Maiko Niki, Michiomi Shimizu, Tohru Nishizawa, Shosaku Nomura
Pulmonary sarcomatoid carcinomas (PSCs) are defined as a group of poorly differentiated non-small cell lung cancers that demonstrate sarcoma-like differentiation. The mechanism of mesenchymal differentiation in PSC is epithelial-mesenchymal transition (EMT). The expression of homeobox protein NANOG (NANOG), which regulates the pluripotency of embryonic stem cells, is associated with the EMT process. Therefore, the present study aimed to assess the expression level of NANOG and the status of the EMT process in PSC...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28528853/sarcomatoid-renal-cell-carcinoma-and-collecting-duct-carcinoma-discrimination-from-common-renal-cell-carcinoma-subtypes-and-benign-rcc-mimics-on-multiphasic-mdct
#4
Jonathan R Young, Jocelyn A Young, Daniel J A Margolis, Steven Sauk, James Sayre, Allan J Pantuck, Steven S Raman
RATIONALE AND OBJECTIVES: To investigate whether imaging features on multiphasic multidetector computed tomography (MDCT) can help discriminate sarcomatoid renal cell carcinoma (RCC) and collecting duct carcinoma (CDC) from other solid renal masses. MATERIALS AND METHODS: With institutional review board approval for this HIPAA-compliant study, we derived a cohort of 7 sarcomatoid RCCs, 4 CDCs, 165 clear cell RCCs, 56 papillary RCCs, 22 chromophobe RCCs, 49 oncocytomas, and 16 lipid-poor angiomyolipomas with preoperative multiphasic MDCT with up to four phases (unenhanced, corticomedullary, nephrographic, and excretory)...
May 18, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28481375/pleural-mesothelioma-in-household-members-of-asbestos-exposed-workers-in-friuli-venezia-giulia-italy
#5
Flavia D' Agostin, Paola de Michieli, Corrado Negro
OBJECTIVES: Malignant mesothelioma is closely associated to asbestos exposure. One such exposure may occur through contact with occupationally exposed household members and their belongings. This study examines the features of pleural mesothelioma attributable only to asbestos brought home by another family member. MATERIAL AND METHODS: The data sources were 1063 mesothelioma cases diagnosed between 1995 and 2014, from the Friuli Venezia Giulia Mesothelioma Register...
May 8, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28480168/port-site-recurrence-following-a-robotic-laparoscopic-radical-nephroureterectomy-for-sarcomatoid-variant-of-urothelial-carcinoma
#6
Jonathan Elliott Katz, Trinity J Bivalacqua, Noah M Hahn, Nikolai A Sopko
Port Site Recurrence (PSR) following laparoscopic tumor resections has been reported for a variety of tumors. Though PSR is a rare phenomenon, they most commonly occur following nephroureterectomies for upper tract urothelial carcinoma. Herein we report a novel case of a PSR following a robotic assisted nephroureterectomy for the sarcomatoid variant of urothelial carcinoma of the upper urinary tract.
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28463437/primary-malignant-pericardial-sarcomatoid-mesothelioma-an-autopsy-report
#7
Hiroko Muta, Yasuo Sugita, Koichi Ohshima, Hitoshi Otsubo
Primary malignant pericardial sarcomatoid mesothelioma (PMPSM) is an extremely rare tumor with poor prognosis. We present an autopsy case in an 80-year-old man admitted for heart failure after one month of treatment at an outpatient clinic. He died three months after symptom onset. A complete autopsy revealed localization of the tumor to the pericardium without other lesions. Histologically, mainly spindle-shaped atypical cells with hyperchromatic nuclei and nucleoli were observed. Immunohistochemical markers for mesothelioma were positive for calretinin, cytokeratin AE1/AE3, and cytokeratin CAM5...
May 1, 2017: Pathology International
https://www.readbyqxmd.com/read/28454257/sarcomatoid-urothelial-carcinoma-with-chondrosarcomatous-differentiation-of-the-ureter-a-case-report-and-review-of-the-literature
#8
Wei Lu, Yanjun Wang, Yonghong Li, Yun Cao, Hui Han, Fangjian Zhou
Sarcomatoid urothelial carcinoma of the urinary tract is associated with poor prognosis. The majority of sarcomatoid urothelial carcinomas are found in the urinary bladder, while a small minority have been shown to arise from the ureter. In the present case, a 72-year-old male patient was diagnosed with sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the left ureter, and subsequently underwent nephroureterectomy and retroperitoneal lymph node dissection. Two lymph nodes from the renal hilum and one paraaortic lymph node were also found to have metastatic involvement; however, the patient refused to receive chemotherapy or radiotherapy and succumbed to bone and omentum metastasis at 6 months after the initial diagnosis...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28452720/carcinosarcoma-of-skin-sarcomatoid-carcinoma-a-rare-non-melanoma-skin-cancer-case-review
#9
U Wollina, A Koch, J Schönlebe, G Tchernev
Non-melanoma skin cancer incidence is rising worldwide. The leading neoplasias are basal cell carcinoma and squamous cell carcinoma. We report on an 88-year-old female patient with a rapidly grown, symptomless, exophytic tumor of the supraclavicular area. Examination at the dermatology department has revealed a firm, exophytic, reddish tumor covered by crusts, about 4 cm in diameter and easily movable to the ground. The tumor was removed by delayed Mohs surgery (R0 resection). The resulting defect was closed by tissue expansion...
February 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28449664/distinct-immunophenotypes-and-prognostic-factors-in-renal-cell-carcinoma-with-sarcomatoid-differentiation-a-systematic-study-of-19-immunohistochemical-markers-in-42-cases
#10
Wenjuan Yu, Yuewei Wang, Yanxia Jiang, Wei Zhang, Yujun Li
BACKGROUND: Renal cell carcinoma (RCC) with sarcomatoid differentiation is a relatively rare tumor containing both carcinoma and sarcomatoid components. However, there has not been a systemic study on immunophenotypes of renal cell carcinoma with sarcomatoid differentiation, especially using some renal specific immunohistochemical markers. In this study, we aimed to comprehensively investigate the distinct immunophenotypes of RCC with sarcomatoid differentiation to analyze the pathogenesis of sarcomatoid differentiation and identify new prognostic factors in RCC with sarcomatoid differentiation...
April 27, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28438212/primary-follicular-dendritic-cell-sarcoma-of-the-urinary-bladder-the-first-case-report-and-potential-diagnostic-pitfalls
#11
Guang-Jie Duan, You-Li Wu, Hui Sun, Lang Lang, Zhi-Wen Chen, Xiao-Chu Yan
BACKGROUND: Extranodal follicular dendritic cell sarcoma (FDCS) is a very rare malignancy with a variable clinical course. It is often not considered and has the potential to result in a misdiagnosis of other common sarcomas or sarcomatoid carcinomas. This is particularly true with the preoperative biopsy specimen, in which the tissue sample is often small. CASE PRESENTATION: A case of FDCS in a 63-year-old woman, arising in the urinary bladder, a previously unreported site, is described...
April 24, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28436368/-pseudo-pseudoaneurysm-following-robotic-assisted-partial-nephrectomy
#12
Eric Schommer, Julio Gundian, David D Thiel
A 65-year-old female presented to clinic requesting follow up for a history of right robotic partial nephrectomy done at an outside institution 2 years prior. Initial pathology demonstrated a grade 2/4 3.4 cm clear cell renal cell carcinoma with negative margins. There was no tumor necrosis, sarcomatoid differentiation, or lymphovascular invasion. High quality follow up imaging initially revealed a pseudoaneurysm in the central portion of the right kidney. The patient was sent to interventional radiology for angioembolization...
April 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28436365/adverse-pathologic-characteristics-in-the-small-renal-mass-implications-for-active-surveillance
#13
Jamil S Syed, Cayce B Nawaf, James Rosoff, Campbell Bryson, Kevin A Nguyen, Alfredo Suarez-Sarmiento, Maria Serrano, Adam S Kibel, Peter Humphrey, Brian Shuch, Adebowale J Adeniran
INTRODUCTION: Evidence has demonstrated that tumor size is related to adverse oncologic outcomes in small renal tumors (≤ 4 cm). We evaluated the association of adverse pathologic features (APF) with tumor size and survival in patients with a small renal mass (SRM). MATERIALS AND METHODS: We retrospectively reviewed the pathologic characteristics of 380 surgically resected SRMs from a single institution. APFs included lymphovascular invasion, coagulative necrosis, sarcomatoid/rhabdoid features, papillary type II histology, and perinephric fat/renal sinus invasion...
April 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28433471/is-transurethral-resection-alone-enough-for-the-diagnosis-of-histological-variants-a-single-center-study
#14
Marco Moschini, Shahrokh F Shariat, Massimo Freschi, Francesco Soria, David D'Andrea, Mohammad Abufaraj, Beat Foerster, Paolo Dell'Oglio, Emanuele Zaffuto, Agostino Mattei, Andrea Salonia, Francesco Montorsi, Alberto Briganti, Andrea Gallina, Renzo Colombo
INTRODUCTION: To evaluate incidence of histological variants and grade agreement between transurethral resection (TUR) and radical cystectomy (RC) in patients with bladder cancer. METHODS: A total of 779 patients treated with TUR and subsequently with RC between 1990 and 2013 at a single center were analyzed retrospectively. Variant histology classifications used in our analyses were sarcomatoid, small cell, squamous, or micropapillary. Grade agreement was calculated using the Cohen kappa coefficient...
April 19, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28427214/high-mucin-5ac-expression-predicts-adverse-postoperative-recurrence-and-survival-of-patients-with-clear-cell-renal-cell-carcinoma
#15
Haijian Zhang, Yidong Liu, Huyang Xie, Weisi Liu, Qiang Fu, Dengfu Yao, Jiejie Xu, Jianxin Gu
BACKGROUND: Mucin 5AC (MUC5AC), as a member of secreted/gel-forming mucin family, was frequently found to be abnormally expressed in inflammation or malignant diseases. However, the clinic pathologic features and prognostic values of MUC5AC in clear-cell renal cell carcinoma (ccRCC) have not been reported up to now. METHODS: MUC5AC expression was analyzed by immunohistochemistry on tissue microarrays. Kaplan-Meier survival curves, Univariate and Multivariate Cox analysis and newly-established nomogram model were performed to evaluate the prognostic value...
March 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427171/evaluation-of-intracavitary-administration-of-curcumin-for-the-treatment-of-sarcomatoid-mesothelioma
#16
Daniel L Pouliquen, Béatrice Nawrocki-Raby, Joëlle Nader, Stéphanie Blandin, Myriam Robard, Philippe Birembaut, Marc Grégoire
A rat model of sarcomatoid mesothelioma, mimicking some of the worst clinical conditions encountered, was established to evaluate the therapeutic potential of intracavitary curcumin administration.The M5-T1 cell line, selected from a collection established from F344 rats induced with asbestos, produces tumors within three weeks, with extended metastasis in normal tissues, after intraperitoneal inoculation in syngeneic rats. The optimal concentration/time conditions for killing M5-T1 cells with curcumin were first determined in vitro...
February 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420853/sarcomatoid-carcinoma-mimicking-malignant-mesothelioma
#17
Junji Takiguchi, Hirokazu Sakamoto, Nobutaka Inoue
No abstract text is available yet for this article.
2017: Internal Medicine
https://www.readbyqxmd.com/read/28419182/molecular-classification-of-pulmonary-sarcomatoid-carcinomas-suggests-new-therapeutic-opportunities
#18
N Pécuchet, T Vieira, N Rabbe, M Antoine, H Blons, J Cadranel, P Laurent-Puig, M Wislez
Background: Pulmonary sarcomatoid carcinoma (SC) is a rare disease with poor prognosis and with strong inter- and intratumor heterogeneity. However, molecular classification is currently focused on activating MET mutations. We sought to better characterize the molecular diversity of SC using mutational signatures that reflect different mutational processes, such as tobacco-associated adducts (signature 4), BRCA1/BRCA2 deficiency (signature 3) or APOBEC enzyme deamination (signatures 2&13)...
April 13, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28418914/met-exon-14-mutations-as-targets-in-routine-molecular-analysis-of-primary-sarcomatoid-carcinoma-of-the-lung
#19
Raphaël Saffroy, Vincent Fallet, Nicolas Girard, Julien Mazieres, Denis Moro Sibilot, Sylvie Lantuejoul, Isabelle Rouquette, Françoise Thivolet-Bejui, Thibaut Vieira, Martine Antoine, Jacques Cadranel, Antoinette Lemoine, Marie Wislez
MET exon 14 splicing mutations are new targetable oncogenic drivers reported in 3% of non-small cell lung cancer (NSCLC) cases and have been shown to be more common in pulmonary sarcomatoid carcinomas (PSCs). This study sought to screen mutations affecting MET exon 14 splice sites in a large SC cohort of Caucasian patients, with a large adenocarcinoma cohort as internal control.We tested 81 patients with SC and 150 with adenocarcinoma for splice site DNA mutations leading to RNA splicing-based skipping of MET exon 14...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28416105/do-clear-cell-papillary-renal-cell-carcinomas-have-malignant-potential-diolombi-ml-cheng-l-argani-p-epstein-ji-am-j-surg-pathol-december-2015-39-12-1621-1634
#20
Oleksandr N Kryvenko
There have been no recurrences or metastases of clear cell papillary renal cell carcinoma (CCPRCC) in 268 reported cases with follow-up in the English-language literature. We identified all our cases of CCPRCC (1990-2013), reviewing all cases that preceded the formal designation of the entity. Immunohistochemical stains were performed on 32 cases during their initial workup. In addition, stains for carbonic anhydrase IX and cytokeratin 7 were performed on 2 cases, one with atypical follow-up and the other with a more compact morphology, although not performed initially...
April 13, 2017: Urologic Oncology
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