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https://www.readbyqxmd.com/read/27900023/synchronous-papillary-urothelial-carcinoma-of-the-bladder-and-squamous-cell-carcinoma-with-sarcomatoid-differentiation-a-case-report
#1
Mahizer Yaldiz, Nur Cihan Cosansu, Berna Solak, Zeynep Kahyaoglu, Mustafa Teoman Erdem
The incidence rate of multiple primary tumors is 37% in all types of cancer. A patient diagnosed with primary cancer is 1.29 times more likely to develop an additional primary cancer when compared with the general population. Furthermore, in patients diagnosed with primary cancer, the possibility of a secondary malignancy in the same or different organ is increased. Following the identification of a secondary tumor, the risk of relapse or metastasis must be considered. The present study reports the case of a 76-year-old man who was admitted to Sakarya University Training and Research Hospital (Sakarya, Turkey) with swelling of the head, which had been apparent for 15 days...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27899694/non-small-cell-carcinoma-of-the-lung-with-osteoclast-like-giant-cells
#2
Hans Helmut Dahm
Carcinomas of the lung with benign osteoclast-like giant cells are rare. A literature search showed only 8 previously reported examples. These tumors resemble a giant cell tumor of bone. Many of these tumors, which occur in most epithelium-containing organs, are composed of an undifferentiated, sarcomatoid component that contains benign osteoclast-like giant cells and a conventional carcinoma. In some tumors the epithelial origin may be revealed by immunohistochemistry only; others lack any evidence of an epithelial component...
November 29, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27891517/prognostic-significance-of-preoperative-neutrophil-to-lymphocyte-ratio-in-nonmetastatic-renal-cell-carcinoma-a-large-multicenter-cohort-analysis
#3
Seok-Soo Byun, Eu Chang Hwang, Seok Ho Kang, Sung-Hoo Hong, Jinsoo Chung, Tae Gyun Kwon, Hyeon Hoe Kim, Cheol Kwak, Yong-June Kim, Won Ki Lee
Background. The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in nonmetastatic renal cell carcinoma (non-mRCC) is controversial, although NLR has been established as a prognostic factor in several cancers. The objective of our study was to assess the prognostic significance of preoperative NLR in non-mRCC, based on a large, multicenter cohort analysis. Methods. Totally, 1,284 non-mRCC patients undergoing surgery were enrolled from six institutions between 2000 and 2014. Recurrence-free survival (RFS) and cancer-specific survival (CSS) were calculated, and the prognostic significance of NLR was evaluated...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27880851/diagnostic-utility-of-pleural-fluid-cell-block-versus-pleural-biopsy-collected-by-flex-rigid-pleuroscopy-for-malignant-pleural-disease-a-single-center-retrospective-analysis
#4
Shion Miyoshi, Shinji Sasada, Takehiro Izumo, Yuji Matsumoto, Takaaki Tsuchida
BACKGROUND: Some trials recently demonstrated the benefit of targeted treatment for malignant disease; therefore, adequate tissues are needed to detect the targeted gene. Pleural biopsy using flex-rigid pleuroscopy and pleural effusion cell block analysis are both useful for diagnosis of malignancy and obtaining adequate samples. The purpose of our study was to compare the diagnostic utility between the two methods among patients with malignant pleural disease with effusion. METHODS: Data from patients who underwent flex-rigid pleuroscopy for diagnosis of pleural effusion suspicious for malignancy at the National Cancer Center Hospital, Japan between April 2011 and June 2014 were retrospectively reviewed...
2016: PloS One
https://www.readbyqxmd.com/read/27871860/in%C3%A2-vitro-reconstitution-of-breast-cancer-heterogeneity-with-multipotent-cancer-stem-cells-using-small-molecules
#5
Masaki Kawamata, Takeshi Katsuda, Yasuhiro Yamada, Takahiro Ochiya
A small fraction of tumor cells are thought to possess the potential for both multiple-lineage differentiation and self-renewal, which underlies the cancer stem cell hypothesis. However, the differentiation mechanisms of these cells have not been elucidated due to a lack of appropriate culture methods. Here, we established a culture condition for maintaining multipotent tumor cells from rat breast tumors using 4 small molecules. Cultured tumor cells in this condition retained their intrinsic myoepithelial features, expressing p63 and CK14 and vimentin...
November 18, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27856426/cytotoxic-t-cells-in-pd-l1-positive-malignant-pleural-mesotheliomas-are-counterbalanced-by-distinct-immunosuppressive-factors
#6
Mark M Awad, Robert E Jones, Hongye Liu, Patrick H Lizotte, Elena V Ivanova, Meghana Kulkarni, Grit S Herter-Sprie, Xiaoyun Liao, Abigail A Santos, Mark A Bittinger, Lauren Keogh, Shohei Koyama, Christina Almonte, Jessie M English, Julianne Barlow, William G Richards, David A Barbie, Adam J Bass, Scott J Rodig, F Stephen Hodi, Kai W Wucherpfennig, Pasi A Jänne, Lynette M Sholl, Peter S Hammerman, Kwok-Kin Wong, Raphael Bueno
PD-L1 immunohistochemical staining does not always predict whether a cancer will respond to treatment with PD-1 inhibitors. We sought to characterize immune cell infiltrates and the expression of T-cell inhibitor markers in PD-L1-positive and PD-L1-negative malignant pleural mesothelioma samples. We developed a method for immune cell phenotyping using flow cytometry on solid tumors that have been dissociated into single-cell suspensions and applied this technique to analyze 43 resected malignant pleural mesothelioma specimens...
December 2016: Cancer Immunology Research
https://www.readbyqxmd.com/read/27853077/definitive-chemoradiotherapy-for-advanced-pulmonary-sarcomatoid-carcinoma
#7
Kazuya Takeda, Haruo Matsushita, Masaki Kubozono, Takaya Tanabe, Yojiro Ishikawa, Takaya Yamamoto, Maiko Kozumi, Noriyoshi Takahashi, Yu Katagiri, Shun Tasaka, Katsuya Fukui, Ken Takeda, Fumiyoshi Fujishima, Masakazu Ichinose, Keiichi Jingu
Pulmonary sarcomatoid carcinoma is a rare subtype of non-small cell lung cancer with a poor prognosis. We herein report on a case of pulmonary sarcomatoid carcinoma that was treated successfully by concurrent chemoradiotherapy. A 65-year-old man was diagnosed to have pulmonary pleomorphic carcinoma (clinical T4N2M0 stage IIIB). He received concurrent chemoradiotherapy (60 Gy of radiotherapy in 30 fractionations and two courses of chemotherapy with carboplatin and paclitaxel). After chemoradiotherapy, a significant reduction of the tumor size was observed...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27852093/poorly-differentiated-pancreatic-carcinoma-with-sarcomatoid-differentiation-confocal-endomicroscopy-of-an-uncommon-pancreatic-cystic-lesion
#8
Feng Li, Samer El-Dika, Rohan M Modi, Wei Chen, Somashekar G Krishna
No abstract text is available yet for this article.
January 2016: Endoscopy
https://www.readbyqxmd.com/read/27847081/complete-resection-of-thymic-sarcomatoid-carcinoma-through-total-aortic-arch-replacement
#9
Soichi Oka, Akihiro Taira, Shuichi Shinohara, Taiji Kuwata, Masaru Takenaka, Yasuhiro Chikaishi, Ayako Hirai, Hidetaka Uramoto, Yosuke Nishimura, Fumihiro Tanaka
Sarcomatoid carcinoma of the thymus is extremely rare. An operation remains the only effective treatment for this disease. We report a case of complete resection of thymic sarcomatoid carcinoma through a total aortic arch replacement and left upper lobectomy at our institution. Our aggressive operation was very effective, and the patient has experienced no recurrence in the 3 years since his operation.
December 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27844145/presence-of-sarcomatoid-differentiation-as-a-prognostic-indicator-for-survival-in-surgically-treated-metastatic-renal-cell-carcinoma
#10
Liangyou Gu, Hongzhao Li, Hanfeng Wang, Xin Ma, Lei Wang, Luyao Chen, Wenlei Zhao, Yu Zhang, Xu Zhang
PURPOSE: To assess the prognostic significance of sarcomatoid differentiation for surgically treated metastatic renal cell carcinoma (mRCC). METHODS: Patients undergoing cytoreductive nephrectomy for mRCC in our center between 2006 and 2014 were included. All enrolled patients were separated into two groups according to the presence of sarcomatoid differentiation. Clinical and pathological variables were recorded. Student's t test or Chi-square test was applied to compare them...
November 14, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27826556/living-donor-liver-transplantation-for-hepatocellular-carcinoma-achieves-better-outcomes
#11
REVIEW
Chih-Che Lin, Chao-Long Chen
Liver transplantation (LT) for hepatocellular carcinoma (HCC) at Kaohsiung Chang Gung Memorial Hospital mainly relies on live donor LT (LDLT). Owing to taking the risk of LD, we are obligated to adopt strict selection criteria for HCC patients and optimize the pre-transplant conditions to ensure a high disease-free survival similar to those without HCC, even better than deceased donor LT (DDLT). Better outcomes are attributed to excellent surgical results and optimal patient selection. The hospital mortality of primary and salvage LDLT are lower than 2% in our center...
October 2016: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/27821833/-pulmonary-carcinosarcoma-presenting-hemothorax-caused-by-pleural-invasion-report-of-a-case
#12
Nobukata Kazawa, Yuta Shibamoto, Yukiya Kitabayashi, Yumi Ishihara, Taeko Gotoh, Yuusuke Sawada, Ryo Inukai, Takashi Tsujimura, Hideo Hattori, Akio Niimi, Ryoichi Nakanishi, Masanori Kitaichi
A 71-year-old man presented with hemothorax with cough, sputa and worsening dyspnea. On chest X-ray and computed tomography(CT), a huge tumor in the right upper lobe with hematoma and small amount of gas suggesting hemopneumothorax was revealed. No apparent lymphadenopathy nor intrapulmonary metastases were observed. The tumor showed a little enhancement on the contrastenhanced CT. Then the resction of the tumor was performed, and the pathological evaluation revealed a carcionosarcoma (adenocarcinoma+osteosarcoma) pT3N0 (stage II B) G4 pl2...
November 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27818288/clinical-significance-of-prominent-retraction-clefts-in-invasive-urothelial-carcinoma
#13
Tanmay S Shah, Matthew Kaag, Jay D Raman, Wilson Chan, Truc Tran, Sudhir Kunchala, Lauren Shuman, David J DeGraff, Guoli Chen, Joshua I Warrick
Micropapillary morphology in invasive urothelial carcinoma is an established predictor of aggressive disease. It is unknown, however, if prominent retraction is associated with more aggressive disease in the absence of classic micropapillary morphology. We reviewed a retrospective series of 309 radical cystectomy specimens with clinical follow-up data, and documented the presence or absence of invasive urothelial carcinoma with "prominent retraction clefts," defined as invasive carcinoma with retraction involving the majority of invasive tumor nests in at least one 100X field, but without classic micropapillary morphology...
November 3, 2016: Human Pathology
https://www.readbyqxmd.com/read/27803966/contemporary-treatment-patterns-and-outcomes-of-sarcomatoid-bladder-cancer
#14
Wilson Sui, Justin T Matulay, Ifeanyi C Onyeji, Marissa C Theofanides, Maxwell B James, Arindam RoyChoudhury, Sven Wenske, G Joel DeCastro
PURPOSE: To characterize the treatment patterns and survival outcomes of sarcomatoid bladder cancer, a rare urothelial variant histology using a large population level cancer database. METHODS: The National Cancer Database was queried for all cases of sarcomatoid bladder cancer using International Classification of Disease-O-3 morphologic code 8122 between 2004 and 2014. Primary outcome was overall survival. RESULTS: A total of 489 patients met our inclusion criteria and were included in our analysis...
November 1, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27803412/sarcomatoid-type-primary-pericardial-mesothelioma-with-a-long-term-survival-after-the-onset-of-cardiac-tamponade
#15
Chika Saisho, Hidenobu Ishii, Nobutaka Edakuni, Yohei Imamura, Takaaki Tokito, Takashi Kinoshita, Koichi Azuma, Kazuhiko Yamada, Tomoaki Hoshino
Primary pericardial malignant mesothelioma is a very rare clinical entity and its prognosis is very poor. We herein report a 67-year-old man who presented with pericardial mesothelioma that was diagnosed 21 months after the onset of cardiac tamponade as the initial manifestation. Despite undergoing pericardiocentesis and surgical pericardial fenestration at the onset of cardiac tamponade, we were unable to make a conclusive diagnosis of mesothelioma based on the cytological and histological findings. This unusual case had a relatively long progression-free period without treatment before the appearance of pleural tumors that showed the histological features of malignant sarcomatoid mesothelioma...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27798081/myxoid-variant-epithelioid-pleural-mesothelioma-defines-a-favourable-prognosis-group-an-analysis-of-191-patients-with-pleural-malignant-mesothelioma
#16
Fouad Sami Alchami, Richard Luther Attanoos, Andrew Richard Bamber
Malignant pleural mesothelioma shows marked cytoarchitectural diversity. The aim of the study was to evaluate how morphological phenotype impacted upon overall survival. 191 cases of malignant pleural mesothelioma with available follow-up were identified, examined and classified according to histological types. The epithelioid mesotheliomas were further subdivided according to morphological subtypes: myxoid, microcystic, tubulopapillary, solid epithelioid, micropapillary and pleomorphic; biphasic mesotheliomas were divided into epithelioid component dominant and sarcomatoid component dominant; pure sarcomatoid mesotheliomas were divided into not otherwise specified, leiomyoid, desmoplastic and heterologous...
October 18, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27797363/constitutively-activated-pi3k-accelerates-tumor-initiation-and-modifies-histopathology-of-breast-cancer
#17
M R Sheen, J D Marotti, M J Allegrezza, M Rutkowski, J R Conejo-Garcia, S Fiering
The gene encoding phosphatidylinositol 3-kinase catalytic subunit α-isoform (PIK3CA, p110α) is frequently activated by mutation in human cancers. Based on detection in some breast cancer precursors, PIK3CA mutations have been proposed to have a role in tumor initiation. To investigate this hypothesis, we generated a novel mouse model with a Cre-recombinase regulated allele of p110α (myristoylated-p110α, myr-p110α) along with p53(fl/fl) deletion and Kras(G12D) also regulated by Cre-recombinase. After instillation of adenovirus-expressing Cre-recombinase into mammary ducts, we found that myr-p110α accelerated breast tumor initiation in a copy number-dependent manner...
October 31, 2016: Oncogenesis
https://www.readbyqxmd.com/read/27780599/calretinin-but-not-caveolin-1-correlates-with-tumour-histology-and-survival-in-malignant-mesothelioma
#18
Bibhusal Thapa, Marzena Walkiewicz, Carmel Murone, Khashayar Asadi, Siddhartha Deb, Stephen Barnett, Simon Knight, Paul Mitchell, Danny Liew, D Neil Watkins, Thomas John
Malignant mesothelioma (MM) continues to be a disease with poor prognosis and limited treatment options. Calretinin and caveolin-1 expression by tumour in MM have recently been described to be associated with tumour histology, differentiation and consequently survival. In a large, well annotated cohort, we studied both of these biomarkers and explored their association with clinicopathological parameters and survival. A retrospective search of patients with MM who underwent surgery at the Austin Hospital in Melbourne, Australia, was conducted...
October 22, 2016: Pathology
https://www.readbyqxmd.com/read/27777776/high-dose-interleukin2-a-10-year-single-site-experience-in-the-treatment-of-metastatic-renal-cell-carcinoma-careful-selection-of-patients-gives-an-excellent-outcome
#19
S Chow, V Galvis, M Pillai, R Leach, E Keene, A Spencer-Shaw, A Shablak, J Shanks, T Liptrot, F Thistlethwaite, R E Hawkins
BACKGROUND: VEGF-targeted therapy has become the mainstay of treatment for majority of mRCC patients. For most patients, benefit is short-lived and therefore treatment remains palliative in intent. HD IL2 is an effective immunotherapy treatment capable of durable remission in some patients but its unselected use has been difficult due to its modest response rate and considerable adverse effects. Using set pathology criteria as a selection tool in clinical practice, we have been able to show improved outcomes in our previous report...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27774043/polyanionic-biopolymers-for-the-delivery-of-pt-ii-cationic-antiproliferative-complexes
#20
Mauro Ravera, Elisabetta Gabano, Ilaria Zanellato, Elena Perin, Aldo Arrais, Domenico Osella
Phenanthriplatin, that is, (SP-4-3)-diamminechlorido(phenanthridine)platinum(II) nitrate, an effective antitumor cationic Pt(II) complex, was loaded on negatively charged dextran sulfate (DS) as a model vector for drug delivery via electrostatic interactions. The free complex and the corresponding conjugate with DS were tested on two standard human tumor cell lines, namely, ovarian A2780 and colon HCT 116, and on several malignant pleural mesothelioma cell lines (namely, epithelioid BR95, mixed/biphasic MG06, sarcomatoid MM98, and sarcomatoid cisplatin-resistant MM98R)...
2016: Bioinorganic Chemistry and Applications
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