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https://www.readbyqxmd.com/read/28645484/immune-check-point-inhibition-in-sarcomatoid-renal-cell-carcinoma-a-new-treatment-paradigm
#1
Ruben Raychaudhuri, Matthew J Riese, Kathryn Bylow, John Burfeind, Alexander C Mackinnon, Parag P Tolat, Kenneth A Iczkowski, Deepak Kilari
No abstract text is available yet for this article.
May 25, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28638113/clinical-significance-and-next-generation-sequencing-of-chinese-pulmonary-sarcomatoid-carcinoma
#2
Xin Li, Dan Wang, Qingchun Zhao, Dian Ren, Fan Ren, Gang Chen, Hongyu Liu, Jun Chen
Pulmonary Sarcomatoid Carcinoma (PSC) constitutes a heterogeneous group of non-small-cell lung carcinomas (NSCLCs) with a poor prognosis. In this study, a group of 7 patients with PSC was studied. Microscope analysis of all 7 cases revealed a pleomorphic carcinoma subtype. Moreover, 5 cases (71.4%) were composed entirely of malignant sarcomatoid-like elements, and 2 cases (28.6%) were composed of malignant sarcomatoid-like elements and at least 10% adenocarcinoma-like elements. Immunohistochemically, the PSC components of all 7 cases were positive for vimentin and cytokeratins, including cytokeratin (CK) and cytokeratin 7 (CK7)...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28637281/pulmonary-sarcomatoid-carcinoma-a-new-hope
#3
J M Boland, A S Mansfield, A C Roden
No abstract text is available yet for this article.
June 15, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28633587/sarcomatoid-carcinoma-manifesting-as-recurrent-rectal-cancer-and-mimicking-radiation-induced-extraskeletal-osteosarcoma-a-case-report
#4
MiJo Lee, Hyun-Jin Son, Je-Ho Jang, Hyun-Young Han, Moon Hyang Park
Here, we report an unusual case of sarcomatoid carcinoma mimicking extraskeletal osteosarcoma that manifested as recurrent rectal cancer. Five years earlier, a 76-year-old male patient had undergone neoadjuvant chemoradiotherapy followed by a laparoscopic low anterior resection due to adenocarcinoma of the rectum. He was admitted because of pain in the anus and left hip. He underwent abdominal computed tomography that revealed a newly developed left perirectal mass with gluteus maximus invasion measuring up to 8 cm, and therefore, an abdominoperineal resection was performed...
June 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28625005/dose-dense-mvac-prior-to-radical-cystectomy-a-real-world-experience
#5
Homayoun Zargar, Jay B Shah, Elisabeth E Fransen van de Putte, Kylea R Potvin, Kamran Zargar-Shoshtari, Bas W van Rhijn, Siamak Daneshmand, Jeff M Holzbeierlein, Philippe E Spiess, Eric Winquist, Simon Horenblas, Colin Dinney, Peter C Black, Wassim Kassouf
PURPOSE: Our primary endpoint was to assess pathological response rate (pT0N0 and ≤pT1N0) for patients with BCa treated with the accelerated or dose dense MVAC (ddMVAC) chemotherapy followed by radical cystectomy (RC) in this real-word multi-institutional cohort. MATERIALS AND METHODS: We retrospectively reviewed records of patients with urothelial cancer who underwent ddMVAC and RC at seven contributing institutions from 2000 to 2015. Patients with cT2-4a, M0 BCa were included...
June 17, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28620133/the-pvhl172-isoform-is-not-a-tumor-suppressor-and-up-regulates-a-subset-of-pro-tumorigenic-genes-including-tgfb1-and-mmp13
#6
P Hascoet, F Chesnel, F Jouan, C Le Goff, A Couturier, E Darrigrand, F Mahé, N Rioux-Leclercq, X Le Goff, Y Arlot-Bonnemains
The von Hippel-Lindau (VHL) tumor suppressor gene is often deleted or mutated in ccRCC (clear cell renal cell carcinoma) producing a non-functional protein. The gene encodes two mRNA, and three protein isoforms (pVHL213, pVHL160 and pVHL172). The pVHL protein is part of an E3 ligase complex involved in the ubiquitination and proteasomal degradation of different proteins, particularly hypoxia inducible factors (HIF) that drive the transcription of genes involved in the regulation of cell proliferation, angiogenesis or extracellular matrix remodelling...
June 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28614203/gata3-immunohistochemistry-for-distinguishing-sarcomatoid-and-desmoplastic-mesothelioma-from-sarcomatoid-carcinoma-of-the-lung
#7
Kyra B Berg, Andrew Churg
The separation of sarcomatoid and desmoplastic malignant mesotheliomas from sarcomatoid carcinomas of the lung metastatic to the pleura may be difficult, since both types of tumor can be morphologically similar and are frequently positive only for pan-keratin. GATA binding protein 3 (GATA3) is most commonly used as an immunohistochemical marker of breast and urothelial carcinoma, but is also known to stain other types of tumors including some mesotheliomas. In this study we asked whether GATA3 stains could be used to distinguish sarcomatoid/desmoplastic malignant mesotheliomas (N=19) from sarcomatoid carcinomas of the lung (N=13)...
June 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28600666/papillary-thyroid-carcinoma-metastasizing-to-anaplastic-meningioma-an-unusual-case-of-tumor-to-tumor-metastasis
#8
Sumit Das, Navjot Chaudhary, Lee-Cyn Ang, Joseph S Megyesi
Tumor-to-tumor metastasis is a relatively uncommon entity, whereby the so-called 'recipient' tumor is involved by another biologically unrelated 'donor' tumor. Intracranially, meningioma (WHO grade 1) is the most common recipient tumor, while breast and lung cancers are the most common donor tumors. We present an unusual case of intracranial tumor-to-tumor metastasis involving papillary thyroid carcinoma (PTC) believed to have metastasized to an anaplastic meningioma (WHO grade 3). The patient is a 64-year-old female with a history of PTC, whose neuroimaging, performed as part of her staging workup, revealed a right parietal scalp lesion...
June 9, 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28596515/characterization-of-a-new-murine-cell-line-of-sarcomatoid-hepatocellular-carcinoma-and-its-application-for-biomarker-therapy-development
#9
Chia-Hung Yen, Chih-Chung Lai, Chen-Chung Liao, Sheng-Fan Wang, Yi-Jen Liao, Chien-Yi Tung, Jung-Hsien Hung, Shiu-Feng Huang, Yi-Ming Arthur Chen
Sarcomatoid hepatocellular carcinoma (SHC) is a rare type of HCC with significantly poorer survival than ordinary HCC. Little is known about the mechanism associated with SHC and its biomarkers and therapy. Here, we established a mouse liver cancer cell line and designated as Ymac-1. A sarcomatous appearance was observed in the allograft tumor arose from Ymac-1. Liver-secreted plasma proteins were found in Ymac-1 cultured supernatant by proteomics analysis. The positive staining of CK7, CK8, Vimentin and the suppressed expression of AFP indicated that Ymac-1 is a SHC cell line...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28594087/adult-prostatic-sarcoma-a-contemporary-multicenter-rare-cancer-network-study
#10
Berardino De Bari, Bradley Stish, Mark Wayne Ball, Yacob Habboush, Paul Sargos, Marco Krengli, Alberto Bossi, Armando Stabile, Claudio Sole Pesutic, Laëtitia Lestrade, Robert Jan Smeenk, Barbara Alicja Jereczek-Fossa, Thomas Zilli, Gilles Créhange, Filippo Alongi, Nicholas Zaorsky, Mahmut Ozsahin
INTRODUCTION: Adult prostatic sarcoma (PS) is a rare disease. While surgery is considered the standard approach, the role of other therapies is not completely established. We report results of the largest multicentric contemporary cohort of PS patients. MATERIALS AND METHODS: This study included 61 adult PS patients treated in 16 American and European Institutions. Median age was 64.4 years (range: 22-87). Curative surgery was delivered in 48 patients (prostatectomy = 26, cystoprostatectomy = 22), usually with lymphadenectomy (n = 40)...
June 8, 2017: Prostate
https://www.readbyqxmd.com/read/28562336/synergistic-targeting-of-malignant-pleural-mesothelioma-cells-by-mdm2-inhibitors-and-trail-agonists
#11
Loredana Urso, Ilaria Cavallari, Micol Silic-Benussi, Lorena Biasini, Giulia Zago, Fiorella Calabrese, Pier Franco Conte, Vincenzo Ciminale, Giulia Pasello
Malignant Pleural Mesothelioma (MPM) is a chemoresistant tumor characterized by low rate of p53 mutation and upregulation of Murine Double Minute 2 (MDM2), suggesting that it may be effectively targeted using MDM2 inhibitors. In the present study, we investigated the anticancer activity of the MDM2 inhibitors Nutlin 3a (in vitro) and RG7112 (in vivo), as single agents or in combination with rhTRAIL.In vitro studies were performed using MPM cell lines derived from epithelioid (ZL55, M14K), biphasic (MSTO211H) and sarcomatoid (ZL34) MPMs...
May 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28561708/systemic-therapy-for-non-clear-cell-renal-cell-carcinoma
#12
Tian Zhang, Jun Gong, Manuel Caitano Maia, Sumanta K Pal
Treatment options for metastatic clear cell renal cell carcinoma (ccRCC) have evolved markedly over the past decade, with multiple targeted therapies approved for the disease. In contrast, little improvement has been made in the management of metastatic non-clear cell RCC (nccRCC). Non-clear cell disease is an umbrella term that encompasses multiple biologically distinct entities, including but not limited to papillary, chromophobe, and sarcomatoid RCC. To date, prospective studies have largely explored treatments for ccRCC (e...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28558669/calretinin-as-a-blood-based-biomarker-for-mesothelioma
#13
Georg Johnen, Katarzyna Gawrych, Irina Raiko, Swaantje Casjens, Beate Pesch, Daniel G Weber, Dirk Taeger, Martin Lehnert, Jens Kollmeier, Torsten Bauer, Arthur W Musk, Bruce W S Robinson, Thomas Brüning, Jenette Creaney
BACKGROUND: Malignant mesothelioma (MM) is a deadly cancer mainly caused by previous exposure to asbestos. With a latency period up to 50 years the incidence of MM is still increasing, even in countries that banned asbestos. Secondary prevention has been established to provide persons at risk regular health examinations. An earlier detection with tumor markers might improve therapeutic options. Previously, we have developed a new blood-based assay for the protein marker calretinin. Aim of this study was the verification of the assay in an independent study population and comparison with the established marker mesothelin...
May 30, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28558460/-clinic-features-of-laryngeal-carcinosarcoma-and-sarcomatoid-carcinoma
#14
Y J Li, W Y Li, J Wang, Z Q Gao, F Qi, H Jiang
Objective: To investigate the clinic feature, pathology, therapy and prognosis of the sarcomatoid caricinoma or carcinosarcoma of the larynx. Methods: We reviewed the clinical records of 7 patients with laryngeal carcinosarcoma /sarcomatoid caricinoma who were treated at our hospital between June 1996 and August 2016. All patients were men (mean age, 65.9 years; range, 52 to 94 years). Among 7 patients, 6 had a history of smoking; 2 underwent radiotherapy; and 5 patients who didn't undergo radiotherapy complained of hoarseness...
May 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28552571/prognostic-factors-for-survival-of-patients-with-synchronous-or-metachronous-brain-metastasis-of-renal-cell-carcinoma
#15
Se Young Choi, Sangjun Yoo, Dalsan You, In Gab Jeong, Cheryn Song, Bumsik Hong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
INTRODUCTION: We evaluated the oncological outcomes of synchronous or metachronous brain metastasis (BM) of metastatic renal cell carcinoma (RCC) according to clinicopathologic factors. PATIENTS AND METHODS: Patients with metastatic RCC (n = 93) with synchronous and metachronous BM were retrospectively identified. We analyzed patients and tumor characteristics, treatment methods, prognostic factors, BM progression, and overall survival (OS). RESULTS: Seventy-six patients (81...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28550387/correlation-of-c-met-expression-with-pd-l1-expression-in-metastatic-clear-cell-renal-cell-carcinoma-treated-by-sunitinib-first-line-therapy
#16
Solène-Florence Kammerer-Jacquet, Sarah Medane, Karim Bensalah, Jean-Christophe Bernhard, Mokrane Yacoub, Frantz Dupuis, Alain Ravaud, Grégory Verhoest, Romain Mathieu, Benoit Peyronnet, Angélique Brunot, Brigitte Laguerre, Alexandra Lespagnol, Jean Mosser, Frédéric Dugay, Marc-Antoine Belaud-Rotureau, Nathalie Rioux-Leclercq
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is highly metastatic. Cabozantinib, an anti-angiogenic tyrosine kinase inhibitor that targets c-MET, provided interesting results in metastatic ccRCC treatment. OBJECTIVE: To understand better the role of c-MET in ccRCC, we assessed its status in a population of patients with metastatic ccRCC. PATIENTS AND METHODS: For this purpose, tumor samples were analyzed for c-MET expression by immunohistochemistry (IHC), for c-MET copy number alterations by fluorescence in situ hybridization (FISH), and for c-MET mutations by next generation sequencing (NGS) in a retrospective cohort of 90 primary ccRCC of patients with metastases treated by first-line sunitinib...
May 26, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28546727/huge-carcinosarcoma-of-the-endolarynx-a-rare-tumour-with-unusual-presentation
#17
Rakesh Kumar Singh, Richi Sinha, Anju Singh, Sanjay Suman, Madhu Priya
Carcinosarcoma or sarcomatoid carcinoma is a highly malignant variant of squamous cell carcinoma, which comprises 2 to 3 % of all laryngeal cancer. It is considered to be a biphasic tumour, composed of a squamous cell carcinoma (in situ or invasive) and spindle cell carcinoma with sarcomatous appearance. We present a case of huge carcinosarcoma of larynx in a 34 year-old male who developed severe stridor and dysphagia. The diagnosis was confirmed histopathologically, hence the disease was treated through total laryngectomy followed by adjuvant chemotherapy and radiotherapy...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28546525/pazopanib-for-the-treatment-of-non-clear-cell-renal-cell-carcinoma-a-single-arm-open-label-multicenter-phase-ii-study
#18
Ki Sun Jung, Su Jin Lee, Se Hoon Park, Jae-Lyun Lee, Se-Hoon Lee, Jae Yun Lim, Jung Hun Kang, Suee Lee, Sun Young Rha, Kyung Hee Lee, Ho Young Kim, Ho Yeong Lim
Purpose: The optimal treatment strategy for patients with metastatic non-clear cell type renal cell carcinoma (nccRCC) remains unclear. Although several inhibitors of vascular endothelial growth factor have recently shown efficacy against nccRCC, the clinical benefit of pazopanib in nccRCC has not been analyzed. We therefore designed a single-arm, open-label, phase II study to determine the efficacy and safety of pazopanib in patients with nccRCC. Materials and Methods: Patients with locally advanced or metastatic nccRCC, except for collecting duct or sarcomatoid type, received 800mg/day of pazopanib daily until progression of disease or intolerable toxicity...
May 22, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28532559/towards-a-molecular-classification-of-pulmonary-sarcomatoid-carcinomas
#19
EDITORIAL
Aaron S Mansfield, Anja C Roden, Jennifer M Boland
No abstract text is available yet for this article.
June 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28532546/-a-case-report-of-pulmonary-sarcomatoid-carcinoma-with-alk-rearrangement
#20
Yehong Miao, Lin Ling, Xiuqin Zhang, Jian'an Huang
No abstract text is available yet for this article.
May 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
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