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https://www.readbyqxmd.com/read/28315738/pulmonary-sarcomatoid-carcinomas-commonly-harbor-either-potentially-targetable-genomic-alterations-or-high-tumor-mutational-burden-as-observed-by-comprehensive-genomic-profiling
#1
Alexa B Schrock, Shuyu D Li, Garrett M Frampton, James Suh, Eduardo Braun, Ranee Mehra, Steven Buck, Jose A Bufill, Nir Peled, Nagla Abdel Karim, Cynthia Hsieh, Manuel Doria, James Knost, Rong Chen, Sai-Hong Ignatius Ou, Jeffrey S Ross, Philip J Stephens, Paul Fishkin, Vincent A Miller, Siraj M Ali, Balazs Halmos, Jane J Liu
BACKGROUND: Pulmonary sarcomatoid carcinoma (PSC) is a high-grade non-small cell lung carcinoma (NSCLC) characterized by poor prognosis and resistance to chemotherapy. Development of targeted therapeutic strategies for PSC has been hampered due to limited and inconsistent molecular characterization. METHODS: Hybrid-capture based comprehensive genomic profiling (CGP) was performed on DNA from 15,867 FFPE NSCLCs including 125 PSCs (0.8%). Tumor mutational burden (TMB) was calculated from 1...
March 15, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28268170/cytoreductive-nephrectomy-renal-cell-carcinoma-patients-with-venous-tumor-thrombus
#2
E Jason Abel, Philippe E Spiess, Vitaly Margulis, Viraj A Master, Michael Mann, Kamran Zargar, Leonardo D Borregales, Wade J Sexton, Datta Patil, Surena F Matin, Christopher G Wood, Jose A Karam
PURPOSE: Careful selection is critical to identify metastatic renal cell carcinoma (mRCC) patients who are most likely to benefit from cytoreductive nephrectomy (CN). Surgery for mRCC patients with tumor thrombus is complex and may not benefit some patients with very poor overall survival (OS). The objective of this study was to evaluate whether preoperative variables or risk stratification systems could predict OS following CN. METHODS: Prognostic factors for overall OS following surgery were evaluated in mRCC patients with venous tumor thrombus at 5 institutions from 2000-2014...
March 4, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28247362/metabolic-syndrome-negatively-impacts-the-outcome-of-localized-renal-cell-carcinoma
#3
Maximilian Christian Kriegmair, Philipp Mandel, Stefan Porubsky, Julia Dürr, Nina Huck, Philipp Nuhn, Daniel Pfalzgraf, Maurice Stephan Michel, Nina Wagener
The aim of this study was to analyze the impact of metabolic syndrome (MetS) on outcome of patients with localized renal cell carcinoma (RCC). A retrospective database was compiled consisting of 646 patients who underwent surgery for localized RCC between 2005 and 2014. A total of 439 patients were eligible for final analysis. For diagnosis of MetS, the WHO criteria of 1998 were used. Median follow-up was 32 months (ranging from 2 to 119). Kaplan-Meier and log-rank analyses were performed to compare patients with and without MetS or its components...
February 28, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28205183/large-primary-pleural-synovial-sarcoma-with-severe-dyspnea-a-case-report
#4
Minoru Yamaki, Shuji Yonehara, Toshio Noriyuki
BACKGROUND: Synovial sarcoma is a malignant neoplasm of soft tissues. It occurs mainly in the extremities and is closely related to tendons, tendon sheaths, and bursal structures. Primary synovial sarcoma of the pleura and lungs is extremely rare. CASE PRESENTATION: We present the case of a 62-year-old man with a large synovial sarcoma of the left pleura. He presented with general fatigue and severe dyspnea. Chest computed tomography (CT) revealed a 20-cm tumor in the left thoracic cavity...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28197626/kdm6a-and-kdm6b-altered-expression-in-malignant-pleural-mesothelioma
#5
Sian Cregan, Maeve Breslin, Gerard Roche, Sigrid Wennstedt, Lauren MacDonagh, Cinaria Albadri, Yun Gao, Kenneth J O'Byrne, Sinead Cuffe, Stephen P Finn, Steven G Gray
Malignant pleural mesothelioma (MPM) is a rare aggressive cancer of the pleura primarily associated with prior exposure to asbestos. The current standard of care for patients suffering from MPM is a combination of cisplatin and pemetrexed (or alternatively cisplatin and raltitrexed). Most patients, however, die within 24 months of diagnosis. New therapies are therefore urgently required for this disease. Inflammation is thought to be a key element in the pathogenesis of MPM, and recently Kdm6 family members (Kdm6a and Kdm6b) have been identified as playing important roles in inflammatory processes...
March 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28196068/comparison-of-outcomes-following-a-cytological-or-histological-diagnosis-of-malignant-mesothelioma
#6
Sanjeevan Muruganandan, Helman Alfonso, Peter Franklin, Keith Shilkin, Amanda Segal, Nola Olsen, Alison Reid, Nick de Klerk, Aw Bill Musk, Fraser Brims
BACKGROUND: Survival with the epithelioid subtype of malignant mesothelioma (MM) is longer than the biphasic or sarcomatoid subtypes. There is concern that cytology-diagnosed epithelioid MM may underdiagnose the biphasic subtype. This study examines survival differences between patients with epithelioid MM diagnosed by cytology only and other subtypes diagnosed by histology. METHODS: Demographics, diagnosis method, MM subtype and survival were extracted from the Western Australia (WA) Mesothelioma Registry, which records details of all MM cases occurring in WA...
March 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28173675/-multifocal-sarcomatoid-carcinoma-of-small-intestine-with-osteogenic-differentiation-report-of-a-case
#7
X Y Han, J Liu, Q Pan, Z L Shen, L Q Lai, H Q Wei
No abstract text is available yet for this article.
February 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28159495/phase-2-trial-of-sunitinib-and-gemcitabine-in-patients-with-sarcomatoid-and-or-poor-risk-metastatic-renal-cell-carcinoma-michaelson-md-mckay-rr-werner-l-atkins-mb-van-allen-em-olivier-km-song-j-signoretti-s-mcdermott-df-choueiri-tk-cancer-2015-oct-1-121-19
#8
Raman Jay, R R McKay, L Werner, M B Atkins, E M Van Allen, K M Olivier, J Song, S Signoretti, D F McDermott, T K Choueiri
BACKGROUND: Sarcomatoid renal cell carcinoma (RCC) is associated with an aggressive biology and a poor prognosis. Poor-risk RCC is defined by clinical prognostic factors and demonstrates similarly aggressive behavior. No standard treatment exists for patients with sarcomatoid RCC, and treatment options for patients with poor-risk disease are of limited benefit. The objective of this study was to investigate the efficacy of antiangiogenic therapy in combination with cytotoxic chemotherapy in clinically aggressive RCC...
March 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28159492/multi-quadrant-biopsy-technique-improves-diagnostic-ability-in-large-heterogeneous-renal-masses-abel-ej-heckman-je-hinshaw-l-best-s-lubner-m-jarrard-df-downs-tm-nakada-sy-lee-ft-jr-huang-w-ziemlewicz-t-j-urol-2015-oct-194-4-886-91-epub-2015-mar-30-doi-10-1016
#9
Raman Jay, J E Heckman, L Hinshaw, S Best, M Lubner, D F Jarrard, T M Downs, S Y Nakada, F T Lee, W Huang, T Ziemlewicz
PURPOSE: Percutaneous biopsy obtained from a single location is prone to sampling error in large heterogeneous renal masses, leading to nondiagnostic results or failure to detect poor prognostic features. We evaluated the accuracy of percutaneous biopsy for large renal masses using a modified multi-quadrant technique vs. a standard biopsy technique. MATERIALS AND METHODS: Clinical and pathological data for all patients with cT2 or greater renal masses who underwent percutaneous biopsy from 2009 to 2014 were reviewed...
March 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28149933/utility-of-clinical-risk-stratification-in-the-selection-of-muscle-invasive-bladder-cancer-patients-for-neoadjuvant-chemotherapy-a-retrospective-cohort-study
#10
Friedrich-Carl von Rundstedt, Douglas A Mata, Oleksandr N Kryvenko, Anup A Shah, Iny Jhun, Seth P Lerner
Introduction: Level I evidence supports the use of cisplatin-based neoadjuvant chemotherapy (NAC) for muscle-invasive bladder cancer prior to radical cystectomy (RC). On average, 30-40% of patients achieve a complete pathologic response (i.e., stage pT0) after receiving NAC. Some centers risk-stratify patients, suggesting that there may be a higher-risk population that would derive the most benefit from NAC. Recently, a risk-stratification model developed at M.D. Anderson Cancer Center (MDACC) specified criteria for clinical staging and patient selection for NAC...
January 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28133153/-a-case-of-gist-in-the-small-intestine-diagnosed-via-ct-after-repeated-melena-and-removed-by-laparoscopy-assisted-surgery
#11
Hiroyuki Notani, Daisuke Asano, Naoto Fujiwara, Toru Kawamura, Yasushi Sato, Akira Nakashima
A 63-year-old man visited an emergency outpatient unit with the chief complaints of melena and lightheadedness. At the time of the visit, blood tests showed Hb of 4.3 g/dL, suggesting severe anemia, and he exhibited repeated melena, even after hospitalization. Small intestinal bleeding was suspected during endoscopic examination of the lower gastrointestinal tract, and abdominalCT examination suggested a 3.5 cm tumor-like lesion in the jejunum. He was diagnosed as having bleeding of a tumor in the small intestine and consequently underwent laparoscopic surgery...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28130179/clear-cell-papillary-renal-cell-carcinoma-new-clinical-and-imaging-characteristics
#12
Kai Wang, Jessica Zarzour, Soroush Rais-Bahrami, Jennifer Gordetsky
OBJECTIVE: To investigate clear cell papillary (CCP) renal cell carcinoma (RCC), an uncommon tumor of low malignant potential characterized by low-grade, clear cells, showing papillary and tubular architecture. This relatively newly described entity is still being characterized. We present our series of CCP RCC with new clinical and imaging findings. MATERIALS AND METHODS: We reviewed the clinical, pathologic, and imaging findings of 28 CCP RCCs in 21 patients identified from our institution between 2010 and 2016...
January 24, 2017: Urology
https://www.readbyqxmd.com/read/28128276/muc4-a-novel-immunohistochemical-marker-identified-by-gene-expression-profiling-differentiates-pleural-sarcomatoid-mesothelioma-from-lung-sarcomatoid-carcinoma
#13
Vishwa Jeet Amatya, Kei Kushitani, Amany Sayed Mawas, Yoshihiro Miyata, Morihito Okada, Takumi Kishimoto, Kouki Inai, Yukio Takeshima
Sarcomatoid mesothelioma, a histological subtype of malignant pleural mesothelioma, is a very aggressive tumor with a poor prognosis. Histological diagnosis of sarcomatoid mesothelioma largely depends on the histomorphological feature of spindled tumor cells with immunohistochemical reactivity to cytokeratins. Diagnosis also requires clinico-radiological and/or macroscopic evidence of an extrapulmonary location to differentiate it from lung sarcomatoid carcinoma. Although there are promising immunohistochemical antibody panels to differentiate mesothelioma from lung carcinoma, a consensus on the immunohistochemical markers that distinguish sarcomatoid mesothelioma from lung sarcomatoid carcinoma has not been reached and requires further study...
January 27, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28127189/sarcomatoid-carcinoma-of-the-penis
#14
Kiran Shankar, M Vijaya Kumar, C Srinivas, Sandeep Nayak, M N Suma
Sarcomatoid carcinomas are biphasic tumours, which occur at any site in the human body. It rarely affects the penis, with only 38 cases being reported in literature. It may be considered as a variant of squamous cell carcinoma or a dedifferentiated tumour. We report a 60-year old gentleman who presented with a swelling in the glans penis. He underwent a partial penectomy. Histopathology revealed sarcomatoid carcinoma of the penis, which was confirmed by immunohistochemistry. The rarity of this clinical entity makes its diagnosis difficult...
March 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28121626/differential-expression-of-cd44-and-cd24-markers-discriminates-the-epitheliod-from-the-fibroblastoid-subset-in-a-sarcomatoid-renal-carcinoma-cell-line-evidence-suggesting-the-existence-of-cancer-stem-cells-in-both-subsets-as-studied-with-sorted-cells
#15
Chin-Hsuan Hsieh, Shih-Chieh Hsiung, Chi-Tai Yeh, Chih-Feng Yen, Yah-Huei Wu Chou, Wei-Yi Lei, See-Tong Pang, Cheng-Keng Chuang, Shuen-Kuei Liao
Epithelioid and fibroblastoid subsets coexist in the human sarcomatoid renal cell carcinoma (sRCC) cell line, RCC52, according to previous clonal studies. Herein, using monoclonal antibodies to CD44 and CD24 markers, we identified and isolated these two populations, and showed that CD44bright/CD24dim and CD44bright/CD24bright phenotypes correspond to epithelioid and fibroblastoid subsets, respectively. Both sorted subsets displayed different levels of tumorigenicity in xenotransplantation, indicating that each harbored its own cancer stem cells (CSCs)...
January 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28103823/stepwise-addition-of-genetic-changes-correlated-with-histological-change-from-well-differentiated-to-sarcomatoid-phenotypes-a-case-report
#16
Taichiro Goto, Yosuke Hirotsu, Hitoshi Mochizuki, Takahiro Nakagomi, Toshio Oyama, Kenji Amemiya, Masao Omata
BACKGROUND: Sarcomatoid cancer is defined by the World Health Organization as a category of non-small cell lung cancers with sarcoma or sarcoma-like differentiation. They are characterized by poor prognosis and resistance to conventional chemotherapy. However, the mutational profile of sarcomatoid cancer remains yet to be elucidated. Sarcomatoid cancers are usually biphasic tumors composed of carcinomatous and sarcomatous components, but the evolutional development of sarcomatoid cancer is controversial...
January 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28100268/upper-lip-metastasis-of-sarcomatoid-carcinoma-of-the-lung-an-unusual-site-of-disease-a-case-report
#17
Tri Le, Melissa Mayer, Joseph Sailors, David E Gerber, John M Truelson
BACKGROUND: Lip metastases are rare clinical events that are frequently mistaken for other diagnoses. For sarcomatoid lung carcinoma, a rare histologic variant of non-small cell lung cancer, the incidence and pattern of cutaneous spread is poorly understood. CASE PRESENTATION: We present a case of a 79-year-old African American man with a rapidly progressive upper lip cutaneous lesion that provided the first evidence of distant metastatic spread of sarcomatoid lung carcinoma...
January 19, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28099333/sarcomatoid-carcinoma-of-the-common-bile-duct-a-case-report
#18
Shuisheng Zhang, Jia Jia, Xiaoning Bi, Qinglong Jiang, Yajie Zhao, Yingtai Chen, Quan Xu, Zhongmin Lan, Jianwei Zhang, Zhihui Zhang, Chengfeng Wang
RATIONALE: Sarcomatoid carcinoma is an extremely rare lesion in the common bile duct (CBD). PATIENT CONCERNS: We present a case of sarcomatoid carcinoma of the distal CBD in a 51-year-old woman who presented with jaundice and abdominal pain. Whipple's operation was performed successfully. Microscopically, the tumor was a poorly differentiated carcinoma containing a component of sarcoma-like differentiation. The tumor cells displayed spindle-shaped nuclei with occasional mitotic figures...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28096688/extreme-leukocytosis-and-leukemoid-reaction-associated-with-the-lung-sarcomatoid-carcinoma-an-unusual-case-report
#19
Danyang Wang, Haiyan Zhang, Fengkuan Yu, Baijun Fang
PURPOSE: To report a rare case of extreme leukocytosis and leukemoid reaction associated with lung sarcomatoid carcinoma (LSC) and increase people's awareness of the disease. PATIENTS AND METHODS: A 58-year-old male patient was diagnosed with LSC; however, after the end of the second course of chemotherapy, his white blood cells increased gradually without fever or use of medications such as granulocyte colony-stimulating factor and steroids. A bone marrow biopsy then confirmed it to be a leukemoid reaction...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/28090262/rapidly-growing-right-ventricular-outflow-tract-mass-in-patient-with-sarcomatoid-renal-cell-carcinoma
#20
Jongmin Hwang, Yong Hyun Park, Kyung Un Choi, Jeong Su Kim, Ki Won Hwang, Sang Hyun Lee, Min Ku Chon, Soo Yong Lee, Dae Sung Lee
Cardiac metastasis from renal cell carcinoma (RCC) without inferior vena cava (IVC) involvements is extremely rare with few reported cases. Sarcomatoid RCC with rhabdoid feature is a rare pathologic type of RCC having aggressive behavior due to great metastatic potential. Here, we report a case of rapidly growing cardiac metastasis of RCC which brought on right ventricular outflow tract (RVOT) obstruction without IVC and right atrial involvement in a 61-year-old woman. Cardiac arrest occurred during radical nephrectomy and echocardiography revealed mass nearly obstructing the RVOT which was not recognized by preoperative echocardiography 1 month ago...
December 2016: Journal of Cardiovascular Ultrasound
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