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Sarcomatoid Renal Cell Carcinoma

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https://www.readbyqxmd.com/read/28159495/phase-2-trial-of-sunitinib-and-gemcitabine-in-patients-with-sarcomatoid-and-or-poor-risk-metastatic-renal-cell-carcinoma-michaelson-md-mckay-rr-werner-l-atkins-mb-van-allen-em-olivier-km-song-j-signoretti-s-mcdermott-df-choueiri-tk-cancer-2015-oct-1-121-19
#1
Raman Jay, R R McKay, L Werner, M B Atkins, E M Van Allen, K M Olivier, J Song, S Signoretti, D F McDermott, T K Choueiri
BACKGROUND: Sarcomatoid renal cell carcinoma (RCC) is associated with an aggressive biology and a poor prognosis. Poor-risk RCC is defined by clinical prognostic factors and demonstrates similarly aggressive behavior. No standard treatment exists for patients with sarcomatoid RCC, and treatment options for patients with poor-risk disease are of limited benefit. The objective of this study was to investigate the efficacy of antiangiogenic therapy in combination with cytotoxic chemotherapy in clinically aggressive RCC...
January 31, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28159492/multi-quadrant-biopsy-technique-improves-diagnostic-ability-in-large-heterogeneous-renal-masses-abel-ej-heckman-je-hinshaw-l-best-s-lubner-m-jarrard-df-downs-tm-nakada-sy-lee-ft-jr-huang-w-ziemlewicz-t-j-urol-2015-oct-194-4-886-91-epub-2015-mar-30-doi-10-1016
#2
Raman Jay, J E Heckman, L Hinshaw, S Best, M Lubner, D F Jarrard, T M Downs, S Y Nakada, F T Lee, W Huang, T Ziemlewicz
PURPOSE: Percutaneous biopsy obtained from a single location is prone to sampling error in large heterogeneous renal masses, leading to nondiagnostic results or failure to detect poor prognostic features. We evaluated the accuracy of percutaneous biopsy for large renal masses using a modified multi-quadrant technique vs. a standard biopsy technique. MATERIALS AND METHODS: Clinical and pathological data for all patients with cT2 or greater renal masses who underwent percutaneous biopsy from 2009 to 2014 were reviewed...
February 1, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28130179/clear-cell-papillary-renal-cell-carcinoma-new-clinical-and-imaging-characteristics
#3
Kai Wang, Jessica Zarzour, Soroush Rais-Bahrami, Jennifer Gordetsky
OBJECTIVE: To investigate clear cell papillary (CCP) renal cell carcinoma (RCC), an uncommon tumor of low malignant potential characterized by low-grade, clear cells, showing papillary and tubular architecture. This relatively newly described entity is still being characterized. We present our series of CCP RCC with new clinical and imaging findings. METHODS: We reviewed the clinical, pathologic, and imaging findings of 28 CCP RCCs in 21 patients identified from our institution between 2010 and 2016...
January 24, 2017: Urology
https://www.readbyqxmd.com/read/28121626/differential-expression-of-cd44-and-cd24-markers-discriminates-the-epitheliod-from-the-fibroblastoid-subset-in-a-sarcomatoid-renal-carcinoma-cell-line-evidence-suggesting-the-existence-of-cancer-stem-cells-in-both-subsets-as-studied-with-sorted-cells
#4
Chin-Hsuan Hsieh, Shih-Chieh Hsiung, Chi-Tai Yeh, Chih-Feng Yen, Yah-Huei Wu Chou, Wei-Yi Lei, See-Tong Pang, Cheng-Keng Chuang, Shuen-Kuei Liao
Epithelioid and fibroblastoid subsets coexist in the human sarcomatoid renal cell carcinoma (sRCC) cell line, RCC52, according to previous clonal studies. Herein, using monoclonal antibodies to CD44 and CD24 markers, we identified and isolated these two populations, and showed that CD44bright/CD24dim and CD44bright/CD24bright phenotypes correspond to epithelioid and fibroblastoid subsets, respectively. Both sorted subsets displayed different levels of tumorigenicity in xenotransplantation, indicating that each harbored its own cancer stem cells (CSCs)...
January 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28090262/rapidly-growing-right-ventricular-outflow-tract-mass-in-patient-with-sarcomatoid-renal-cell-carcinoma
#5
Jongmin Hwang, Yong Hyun Park, Kyung Un Choi, Jeong Su Kim, Ki Won Hwang, Sang Hyun Lee, Min Ku Chon, Soo Yong Lee, Dae Sung Lee
Cardiac metastasis from renal cell carcinoma (RCC) without inferior vena cava (IVC) involvements is extremely rare with few reported cases. Sarcomatoid RCC with rhabdoid feature is a rare pathologic type of RCC having aggressive behavior due to great metastatic potential. Here, we report a case of rapidly growing cardiac metastasis of RCC which brought on right ventricular outflow tract (RVOT) obstruction without IVC and right atrial involvement in a 61-year-old woman. Cardiac arrest occurred during radical nephrectomy and echocardiography revealed mass nearly obstructing the RVOT which was not recognized by preoperative echocardiography 1 month ago...
December 2016: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28063846/systematic-expression-analysis-of-mitochondrial-complex-i-identifies-ndufs1-as-a-biomarker-in-clear-cell-renal-cell-carcinoma
#6
Jörg Ellinger, Mirjam Poss, Maria Brüggemann, Arabella Gromes, Doris Schmidt, Nadja Ellinger, Yuri Tolkach, Dimo Dietrich, Glen Kristiansen, Stefan C Müller
INTRODUCTION: Mitochondrial dysfunction is common in cancer, and the mitochondrial electron transport chain is often affected in carcinogenesis. So far, little is known about the expression of the mitochondrial complex I (NADH:ubiquinone oxidoreductase) subunits in clear-cell renal-cell carcinoma (ccRCC). MATERIALS AND METHODS: An expression profile of the mitochondrial complex I subunits was determined using the NextBio database. Subsequently, the expression of selected subunits was experimentally validated on mRNA (quantitative real-time polymerase chain reaction) and protein (Western blot analysis, immunohistochemistry) level...
December 1, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27931799/oncocytic-papillary-renal-cell-carcinoma-a-clinicopathological-and-genetic-analysis-and-indolent-clinical-course-in-14-cases
#7
Guiyan Han, Wenjuan Yu, Jing Chu, Yan Liu, Yanxia Jiang, Yujun Li, Wei Zhang
A sort of PRCC with distinct eosinophilic cytoplasm named Oncocytic Papillary Renal Cell Carcinoma (OPRCC) has been increasingly attracting the attention of researchers recently. However, owing to the rarity of OPRCC, the clinicopathological and genetic features of the tumor have still not been well elucidated and whether it should be regarded as an independent subtype of PRCC remains controversial. Herein, a cohort of 14 OPRCCs was studied with the aim of revealing the distinct clinicopathological features, facilitating the classification and correct diagnosis of OPRCC...
January 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27891517/prognostic-significance-of-preoperative-neutrophil-to-lymphocyte-ratio-in-nonmetastatic-renal-cell-carcinoma-a-large-multicenter-cohort-analysis
#8
MULTICENTER STUDY
Seok-Soo Byun, Eu Chang Hwang, Seok Ho Kang, Sung-Hoo Hong, Jinsoo Chung, Tae Gyun Kwon, Hyeon Hoe Kim, Cheol Kwak, Yong-June Kim, Won Ki Lee
Background. The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in nonmetastatic renal cell carcinoma (non-mRCC) is controversial, although NLR has been established as a prognostic factor in several cancers. The objective of our study was to assess the prognostic significance of preoperative NLR in non-mRCC, based on a large, multicenter cohort analysis. Methods. Totally, 1,284 non-mRCC patients undergoing surgery were enrolled from six institutions between 2000 and 2014. Recurrence-free survival (RFS) and cancer-specific survival (CSS) were calculated, and the prognostic significance of NLR was evaluated...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27844145/presence-of-sarcomatoid-differentiation-as-a-prognostic-indicator-for-survival-in-surgically-treated-metastatic-renal-cell-carcinoma
#9
Liangyou Gu, Hongzhao Li, Hanfeng Wang, Xin Ma, Lei Wang, Luyao Chen, Wenlei Zhao, Yu Zhang, Xu Zhang
PURPOSE: To assess the prognostic significance of sarcomatoid differentiation for surgically treated metastatic renal cell carcinoma (mRCC). METHODS: Patients undergoing cytoreductive nephrectomy for mRCC in our center between 2006 and 2014 were included. All enrolled patients were separated into two groups according to the presence of sarcomatoid differentiation. Clinical and pathological variables were recorded. Student's t test or Chi-square test was applied to compare them...
March 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27777776/high-dose-interleukin2-a-10-year-single-site-experience-in-the-treatment-of-metastatic-renal-cell-carcinoma-careful-selection-of-patients-gives-an-excellent-outcome
#10
S Chow, V Galvis, M Pillai, R Leach, E Keene, A Spencer-Shaw, A Shablak, J Shanks, T Liptrot, F Thistlethwaite, R E Hawkins
BACKGROUND: VEGF-targeted therapy has become the mainstay of treatment for majority of mRCC patients. For most patients, benefit is short-lived and therefore treatment remains palliative in intent. HD IL2 is an effective immunotherapy treatment capable of durable remission in some patients but its unselected use has been difficult due to its modest response rate and considerable adverse effects. Using set pathology criteria as a selection tool in clinical practice, we have been able to show improved outcomes in our previous report...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27689125/paraneoplastic-proteinuria-in-papillary-renal-cell-carcinoma-a-case-report
#11
Fatemeh Yaghoubi, Maliheh Yarmohammadi, Mohammad Vasei
We report a 55-year-old man presented with anemia and weakness, history of flank pain, hematuria and nephrotic syndrome. Spiral abdominopelvic computerized tomography (CT) scan showed multiloculated cystic mass (120 ×100 ×80 mm) in lower portion of left kidney with internal enhancing solid components and coarse peripheral calcifications. Radical nephrectomy of left kidney was done and biopsy confirmed renal cell carcinoma (RCC), papillary type, sarcomatoid foci, Fuhrman grade III. We assumed that, presence of nephrotic syndrome and paraneoplastic glomerulopathy leaded to heavy proteinuria in this case...
2016: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/27623354/independent-association-of-pd-l1-expression-with-noninactivated-vhl-clear-cell-renal-cell-carcinoma-a-finding-with-therapeutic-potential
#12
Solène-Florence Kammerer-Jacquet, Laurence Crouzet, Angélique Brunot, Julien Dagher, Adélaïde Pladys, Julien Edeline, Brigitte Laguerre, Benoit Peyronnet, Romain Mathieu, Grégory Verhoest, Jean-Jacques Patard, Alexandra Lespagnol, Jean Mosser, Marc Denis, Yosra Messai, Sophie Gad-Lapiteau, Salem Chouaib, Marc-Antoine Belaud-Rotureau, Karim Bensalah, Nathalie Rioux-Leclercq
Clear cell renal cell carcinoma (ccRCC) is an aggressive tumor that is characterized in most cases by inactivation of the tumor suppressor gene VHL. The VHL/HIF/VEGF pathway thus plays a major role in angiogenesis and is currently targeted by anti-angiogenic therapy. The emergence of resistance is leading to the use of targeted immunotherapy against immune checkpoint PD1/PDL1 that restores antitumor immune response. The correlation between VHL status and PD-L1 expression has been little investigated. In this study, we retrospectively reviewed 98 consecutive cases of ccRCC and correlated PD-L1 expression by immunohistochemistry (IHC) with clinical data (up to 10-year follow-up), pathological criteria, VEGF, PAR-3, CAIX and PD-1 expressions by IHC and complete VHL status (deletion, mutation and promoter hypermethylation)...
January 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27593224/papillary-type-2-versus-clear-cell-renal-cell-carcinoma-survival-outcomes
#13
G Simone, G Tuderti, M Ferriero, R Papalia, L Misuraca, F Minisola, M Costantini, R Mastroianni, S Sentinelli, S Guaglianone, M Gallucci
AIM: To compare the cancer specific survival (CSS) between p2-RCC and a Propensity Score Matched (PSM) cohort of cc-RCC patients. METHODS: Fifty-five (4.6%) patients with p2-RCC and 920 cc-RCC patients were identified within a prospectively maintained institutional dataset of 1205 histologically proved RCC patients treated with either RN or PN. Univariable and multivariable Cox regression analyses were used to identify predictors of CSS after surgical treatment...
November 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27583351/analysis-of-various-potential-prognostic-markers-and-survival-data-in-clear-cell-renal-cell-carcinoma
#14
Tastekin Ebru, Oz Puyan Fulya, Akdere Hakan, Yurut-Caloglu Vuslat, Sut Necdet, Can Nuray, Ozyilmaz Filiz
PURPOSE: Clear cell renal cell cancers frequently harbor Von Hippel-Lindau gene mutations, leading to stabilization of the hypoxia-inducible factors (HIFs) and their target genes. In this study, we investigated the relationship between vascular endotelial growth factor (VEGF), HIF-1α, HIF-2α, p53 positivity, microvessel density, and Ki-67 rates with prognostic histopathologic factors (Fuhrman nuclear grade, stage, and sarcomatoid differentiation) and survival in clear cell renal cell carcinomas...
September 1, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27579427/sarcomatoid-squamous-cell-carcinoma-of-the-renal-pelvis-masquerading-as-emphysematous-pyelonephritis-with-staghorn-calculus
#15
Dana Kivlin, Carmen Tong, Justin Friedlander, Patricia Perosio, Jay Simhan
BACKGROUND: Staghorn calculi are well-established risk factors for recurrent urinary tract infections (UTIs) and subsequent renal deterioration. Less commonly, long-term urothelial irritation from a calculus may also pose a risk of malignant transformation. CASE PRESENTATION: A 77-year-old male with multiple medical comorbidities presented with a chronic right renal pelvic staghorn calculus and findings concerning for emphysematous pyelonephritis. He was subsequently taken to the operating room for a planned laparoscopic right nephrectomy...
2016: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/27578234/oncological-outcomes-of-minimally-invasive-partial-versus-minimally-invasive-radical-nephrectomy-for-ct1-2-n0-m0-clear-cell-renal-cell-carcinoma-a-propensity-score-matched-analysis
#16
Giuseppe Simone, Gabriele Tuderti, Umberto Anceschi, Rocco Papalia, Mariaconsiglia Ferriero, Leonardo Misuraca, Francesco Minisola, Riccardo Mastroianni, Manuela Costantini, Salvatore Guaglianone, Steno Sentinelli, Michele Gallucci
PURPOSE: To compare the oncologic outcomes of partial nephrectomy (PN) and radical nephrectomy (RN) for cT1-2/N0 renal tumors and pathologically confirmed pT1-pT3a-pNx clear cell (cc)-renal cell carcinoma (RCC). Few studies compared the oncologic outcomes of PN and RN for renal tumors >7 cm. METHODS: A prospective "renal cancer" database was queried for cT<3-cN0-cM0 and pT1a-pT3a-pNx cc-RCC. Out of 1650 cases treated between 2001 and 2013, 921 were cc-RCC and 666 met inclusion criteria, 232 of which treated with minimally invasive RN and 434 with MIPN...
August 30, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27569352/-a-case-of-acd-associated-rcc-with-lymph-node-metastasis-and-contralateral-renal-carcinoma-after-nephrectomy
#17
Yuki Makino, Kazunari Tsuchihashi, Yosuke Shimizu, Sojun Kanamaru, Kimio Hashimoto, Noriyuki Ito
A 59-year-old man who had undergone hemodialysis for 13 years was diagnosed with left renal cell carcinoma (RCC),cT1aN0M0,in 2010. He had a laparoscopic left nephrectomy,and the pathological diagnosis at that time was clear cell carcinoma,pT1a (multifocal). At 1 year after surgery,he was diagnosed with a left renal hilar lymph node metastasis and a new right RCC,cT1aN0M0. Consequently,he underwent a right nephrectomy and retroperitoneal lymph node dissection in 2012. Pathologic diagnosis by the current classification of the right renal tumor was acquired cystic disease-associated renal cell carcinoma (ACD-associated RCC),and that of the left hilar lymph node was metastatic RCC with sarcomatoid change...
July 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/27568124/outcomes-of-patients-with-metastatic-non-clear-cell-renal-cell-carcinoma-treated-with-pazopanib
#18
Marc R Matrana, Ali Baiomy, Matthew Campbell, Suhail Alamri, Aditya Shetty, Purnima Teegavarapu, Sarathi Kalra, Lianchun Xiao, Bradley Atkinson, Paul Corn, Eric Jonasch, Khaled M Elsayes, Nizar M Tannir
BACKGROUND: Pazopanib is associated with increased progression-free survival (PFS) in clear-cell renal cell carcinoma (RCC) and has become a standard of care in this disease. The drug is used in metastatic non-clear-cell RCC, but data on outcomes in this setting are limited. PATIENTS AND METHODS: We conducted a retrospective data analysis of records of consecutive metastatic non-clear-cell RCC patients who received pazopanib in front-line and salvage settings between November 2009 and November 2012...
July 22, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27553579/impact-of-metastasectomy-on-prognosis-in-patients-treated-with-targeted-therapy-for-metastatic-renal-cell-carcinoma
#19
Dalsan You, Chunwoo Lee, In Gab Jeong, Cheryn Song, Jae-Lyun Lee, Bumsik Hong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
PURPOSE: We evaluated the value of metastasectomy in patients treated with targeted therapy for metastatic renal cell carcinoma (mRCC). METHODS: The medical records of 325 patients who presented with mRCC were reviewed; among these patients, 33 underwent complete metastasectomy followed by targeted therapy (complete metastasectomy group), 29 underwent incomplete metastasectomy followed by targeted therapy (incomplete metastasectomy group), and 263 treated with targeted therapy alone (non-metastasectomy group)...
November 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27506336/-duodenal-metastases-from-sarcomatoid-renal-cell-carcinoma-case-report
#20
Uriel Villela-Segura, Jorge García-Leiva, Perla Judith Nuñez Becerra
No abstract text is available yet for this article.
August 6, 2016: Gastroenterología y Hepatología
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