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https://www.readbyqxmd.com/read/29035504/chromophore-catalyst-assembly-for-water-oxidation-prepared-by-atomic-layer-deposition
#1
Leila Alibabaei, Robert J Dillon, Caroline E Reilly, M Kyle Brennaman, Kyung-Ryang Wee, Seth L Marquard, John M Papanikolas, Thomas J Meyer
Visible-light-driven water splitting was investigated in a dye sensitized photoelectrosynthesis cell (DSPEC) based on a photoanode with a phosphonic acid-derivatized donor--acceptor (D--A) organic chromophore, 1, and the water oxidation catalyst [Ru(bda)(4-O(CH2)3P(O3H2)2-pyr)2], 2, (pyr = pyridine; bda = 2,2'-bipyridine-6,6'-dicarboxylate). The photoanode was prepared by using a layering strategy beginning with the organic dye anchored to an FTO|core/shell electrode, atomic layer deposition (ALD) of a thin layer (< 1 nm) of TiO2, and catalyst binding through phosphonate linkage to the TiO2 layer...
October 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29034624/-effects-of-overexpression-of-carboxylation-pathway-genes-and-inactivation-of-malic-enzymes-on-malic-acid-production-in-escherichia-coli
#2
Fei Lou, Ning Li, Yujiao Zhao, Shiting Guo, Zhiwen Wang, Tao Chen
Malic acid is a dicarboxylic acid that is widely used in food, pharmaceutical and chemical industries. We studied the effects of overexpression of carboxylation pathway genes and inactivation of malic enzymes on the aerobic production of malic acid. Over expression of phosphoenolpyruvate (PEP) carboxylase (ppc) generated strain E21, which increased malic acid production from 0.57 g/L to 3.83 g/L. Then pyc gene from Coryenbacterium glutamicus and pck gene from Actinobacillus succinogenes were overexpressed in E21 separately...
November 25, 2016: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/29032659/in-silico-analysis-of-putative-drug-and-vaccine-target-of-the-metabolic-pathways-of-actinobacillus-pleuropneumoniae-using-subtractive-comparative-genomics-approach
#3
Biruk Tesfaye Birhanu, Seung-Jin Lee, Na-Hye Park, Ju-Beom Song, Seung-Chun Park
Actinobacillus pleuropneumoniae is a gram-negative bacterium residing in the respiratory tract of pigs that causes porcine respiratory disease complex, which leads to significant losses in the pig industry worldwide. The incidence of drug resistance in this bacterium is increasing; thus, identifying new protein/gene targets for drug and vaccine development is critical. In this study, we used an in silico approach, utilizing several databases, including Kyoto Encyclopedia of Genes and Genomes (KEGG), the database of essential genes (DEG), DrugBank, and Swiss-Prot, to identify non-homologous essential genes and prioritize these proteins for their druggability...
October 13, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29030856/mitochondrial-3-hydroxy-3-methylglutaryl-coa-synthase-deficiency-unique-presenting-laboratory-values-and-a-review-of-biochemical-and-clinical-features
#4
Erin Conboy, Filippo Vairo, Matthew Schultz, Katherine Agre, Ross Ridsdale, David Deyle, Devin Oglesbee, Dimitar Gavrilov, Eric W Klee, Brendan Lanpher
We report an 8-month-old infant with decreased consciousness after a febrile episode and reduced oral intake. He was profoundly acidotic but his lactate was normal. Serum triglycerides were markedly elevated and HDL cholesterol was very low. The urine organic acid analysis during the acute episode revealed a complex pattern of relative hypoketotic dicarboxylic aciduria, suggestive of a potential fatty acid oxidation disorder. MRI showed extensive brain abnormalities concerning for a primary energy deficiency...
October 14, 2017: JIMD Reports
https://www.readbyqxmd.com/read/29030441/methanogenic-paraffin-biodegradation-alkylsuccinate-synthase-gene-quantification-and-dicarboxylic-acid-production
#5
Lisa K Oberding, Lisa M Gieg
Paraffinic n-alkanes (> C17) that are solid at ambient temperature comprise a large fraction of many crude oils. The comparatively low water solubility and reactivity of these long-chain alkanes can lead to their persistence in the environment following fuel spills, and pose serious problems for crude oil recovery operations by clogging oil production wells. However, the degradation of waxy paraffins under the anoxic conditions characterizing contaminated groundwater environments and deep subsurface energy reservoirs is poorly understood...
October 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29027985/triterpenoids-from-ocimum-labiatum-activates-latent-hiv-1-expression-in-vitro-potential-for-use-in-adjuvant-therapy
#6
Petrina Kapewangolo, Justin J Omolo, Pascaline Fonteh, Martha Kandawa-Schulz, Debra Meyer
Latent HIV reservoirs in infected individuals prevent current treatment from eradicating infection. Treatment strategies against latency involve adjuvants for viral reactivation which exposes viral particles to antiretroviral drugs. In this study, the effect of novel triterpenoids isolated from Ocimum labiatum on HIV-1 expression was measured through HIV-1 p24 antigen capture in the U1 latency model of HIV-1 infection and in peripheral blood mononuclear cells (PBMCs) of infected patients on combination antiretroviral therapy (cART)...
October 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29026900/a-series-of-sulfonic-acid-functionalized-mixed-linker-dut-4-analogues-synthesis-gas-sorption-properties-and-catalytic-performance
#7
Guang-Bo Wang, Karen Leus, Kevin Hendrickx, Jelle Wieme, Hannes Depauw, Ying-Ya Liu, Veronique Van Speybroeck, Pascal Van Der Voort
In this work, we present the successful synthesis of a series of sulfonic acid functionalized mixed-linker metal-organic frameworks (MOFs) having the DUT-4 topology by using different ratios of 2,6-naphthalenedicarboxylic acid (H2-NDC) and 4,8-disulfonaphthalene-2,6-dicarboxylic acid (H2-NDC-2SO3H) in one-pot reactions. The obtained materials were fully characterized and their CO2 adsorption properties at low and high pressures were studied and compared with those of the pristine DUT-4 material. Generally, the CO2 adsorption capacities range from 3...
October 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29024969/preconception-urinary-phthalate-concentrations-and-sperm-dna-methylation-profiles-among-men-undergoing-ivf-treatment-a-cross-sectional-study
#8
Haotian Wu, Molly S Estill, Alexander Shershebnev, Alexander Suvorov, Stephen A Krawetz, Brian W Whitcomb, Holly Dinnie, Tayyab Rahil, Cynthia K Sites, J Richard Pilsner
STUDY QUESTION: Are preconception phthalate and phthalate replacements associated with sperm differentially methylated regions (DMRs) among men undergoing IVF? SUMMARY ANSWER: Ten phthalate metabolites were associated with 131 sperm DMRs that were enriched in genes related to growth and development, cell movement and cytoskeleton structure. WHAT IS KNOWN ALREADY: Several phthalate compounds and their metabolites are known endocrine disrupting compounds and are pervasive environmental contaminants...
September 12, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29022988/a-microporous-mof-with-open-metal-sites-and-lewis-basic-sites-for-selective-co2-capture
#9
Jinjie Qian, Qipeng Li, Linfeng Liang, Ting-Ting Li, Yue Hu, Shaoming Huang
A robust indium-organic framework (InOF-15) with open metal sites and Lewis basic sites has been successfully synthesized using a quinoline-based dicarboxylic acid. Moreover, it exhibits high IAST selective CO2 sorption from CO2/CH4 and CO2/N2 mixtures at 273 K, which has been attributed to the coexistence of OMSs and LBSs with strong synergistic effects.
October 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29019643/skeletal-diversity-in-combinatorial-fashion-a-new-format-for-the-castagnoli-cushman-reaction
#10
Anastasia Lepikhina, Dmitry Dar'in, Olga Bakulina, Evgeny Chupakhin, Mikhail Krasavin
A new format for the Castagnoli-Cushman reaction of structurally diverse dicarboxylic acids, amines and aldehydes in the presence of acetic anhydride as dehydrating agent is described. The reaction is distinctly amenable to parallel format: the combinatorial array of 180 reactions delivered 157 products of >85% purity without chromatographic purification (of this number, 143 compounds had >94% purity). The new method offers a convenient preparation of the skeletally and peripherally diverse, lead- and druglike - and -lactam carboxylic acids with high diastereoselectivity in combinatorial fashion...
October 11, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28994841/phthalocyanine-based-coordination-polymer-nanoparticles-for-enhanced-photodynamic-therapy
#11
Ziyuan Huang, Liangfeng Huang, Yanjuan Huang, Yuanfeng He, Xiaoqi Sun, Xiang Fu, Xiaoyu Xu, Gaofei Wei, Dawei Chen, Chunshun Zhao
In the photodynamic therapy (PDT) of cancer, zinc phthalocyanine (ZnPc) as a photosensitizer possesses superior photosensitive properties. However, the therapeutic effect of ZnPc in PDT is limited due to its aggregation, low solubility and poor selectivity. In this study, charge-reversal phthalocyanine-based coordination polymer nanoparticles (PCPN) are developed for improving the curative effect of ZnPc. Tetra(4-carboxyphenoxy)-phthalocyaninatozinc(ii) (TPZnPc) is coordinated with the zinc ion to form the core of PCPN, which is coated with a lipid bilayer by self-assembly (PCPNs@Lip)...
October 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28993212/biocatalytic-one-pot-diterminal-oxidation-and-esterification-of-n-alkanes-for-production-of-%C3%AE-%C3%AF-diol-and-%C3%AE-%C3%AF-dicarboxylic-acid-esters
#12
Youri M van Nuland, Fons A de Vogel, Elinor L Scott, Gerrit Eggink, Ruud A Weusthuis
Direct and selective terminal oxidation of medium-chain n-alkanes is a major challenge in chemistry. Efforts to achieve this have so far resulted in low specificity and overoxidized products. Biocatalytic oxidation of medium-chain n-alkanes - with for example the alkane monooxygenase AlkB from P. putida GPo1- on the other hand is highly selective. However, it also results in overoxidation. Moreover, diterminal oxidation of medium-chain n-alkanes is inefficient. Hence, α,ω-bifunctional monomers are mostly produced from olefins using energy intensive, multi-step processes...
October 7, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28986952/effect-of-water-on-the-structure-and-stability-of-hydrogen-bonded-oxalic-acid-dimer
#13
Yuan-Chun Hu, Xiu-Hui Zhang, Quan-Song Li, Yun-Hong Zhang, Ze-Sheng Li
As the simplest and the most abundant dicarboxylic acids in the atmosphere, oxalic acid (OA) not only plays a key role in aerosol nucleation, but also acts as a prototypical compound for the investigation of intra- and intermolecular hydrogen bonding interactions. In this work, a systematic theoretical study on the hydrated OA dimers were carried out using density functional theory (DFT) at the M06-2X/6-311++G(3df, 2p) level. The properties of the hydrogen bonds in clusters were inspected through topological analysis using atoms in molecules (AIM) theory...
October 6, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28983758/biotechnological-production-of-bio-based-long-chain-dicarboxylic-acids-with-oleogenious-yeasts
#14
REVIEW
Nicole Werner, Susanne Zibek
Long-chain α,ω-dicarboxylic acids (DCAs) are versatile chemical intermediates of industrial importance used as building blocks for the production of polymers, lubricants, or adhesives. The majority of industrial long-chain DCAs is produced from petro-chemical resources. An alternative is their biotechnological production from renewable materials like plant oil fatty acids by microbial fermentation using oleogenious yeasts. Oleogenious yeasts are natural long-chain DCA producers, which have to be genetically engineered for high-yield DCA production...
October 5, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28981283/direct-surface-tension-measurements-of-individual-submicrometer-particles-using-atomic-force-microscopy
#15
Hansol D Lee, Armando D Estillore, Holly S Morris, Kamal K Ray, Aldair Alejandro, Vicki H Grassian, Alexei V Tivanski
Understanding the role of sea spray aerosol (SSA) on climate and the environment is of great interest due to their high number throughout the Earth's atmosphere. Despite fundamental importance, direct surface tension measurements of SSA relevant submicrometer particles are rare, largely due to their extremely small volumes. Herein, atomic force microscopy (AFM) is used to directly measure the surface tension of individual submicrometer SSA particle mimics at ambient temperature and varying relative humidity (RH)...
October 5, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28977696/mannose-and-galactose-as-substrates-for-production-of-itaconic-acid-by-aspergillus-terreus
#16
B C Saha, G J Kennedy
Itaconic acid (IA), an unsaturated 5-carbon dicarboxylic acid, is a building block platform chemical that is currently produced industrially from glucose by fermentation with Aspergillus terreus. Softwood has the potential to serve as low cost source of sugars for its production. Effective utilization of all softwood derived sugars such as glucose, mannose and galactose by the fungus for production of IA will lower the cost of its production. In this work, 20 A. terreus strains were evaluated for the first time for IA production from mannose and galactose in shake-flasks at initial pH of 3...
October 4, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28976207/metabolomic-profile-of-arterial-stiffness-in-aged-adults
#17
Angela S Koh, Fei Gao, Jin Liu, Kevin Timothy Fridianto, Jianhong Ching, Ru San Tan, Jia-Ing Wong, Serene Jm Chua, Shuang Leng, Liang Zhong, Bryan Mh Keng, Fei Qiong Huang, Jian-Min Yuan, Woon-Puay Koh, Jean-Paul Kovalik
BACKGROUND: Increasing arterial stiffness is an important contributor to declining cardiovascular health in ageing. Changes in whole-body fuel metabolism could be related to alterations in arterial stiffness in ageing adults. METHODS: Targeted high-performance liquid and gas chromatography mass spectrometry were used to measure 84 circulating metabolites in a group of community elderly adults ( n = 141, 58% men; mean age = 70.6 ± 11.2 years) without cardiovascular disease...
October 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28976188/metal-organic-frameworks-with-internal-urea-functionalized-dicarboxylate-linkers-for-so2-and-nh3-adsorption
#18
Sebastian Glomb, Dennis Woschko, Gamall Makhloufi, Christoph Janiak
Introduction of a urea R-NH-CO-NH-R group as a seven-membered diazepine ring at the center of 4,4'-biphenyl-dicarboxylic acid leads to a urea-functionalized dicarbox-ylate linker (L12-) from which four zinc metal-organic frameworks (MOFs) could be obtained, having a {Zn4(µ4-O)(O2C-)6} SBU and IRMOF-9 topology (compound [Zn4(µ4-O)(L1)3], 1, from dimethylformamide, DMF) or a {Zn2(O2C-)4} paddle-wheel SBU in a 2D-network (compound [Zn2(L1)2(DEF)2∙2.5 DEF], 2, from diethylformamide, DEF) . Pillaring of the 2D-network of 2 with 4,4'-bipyridine (bipy) or 4,4'-dipyridylethane (bpe) gives 3D frameworks with rhombohedrally distorted pcu-a topologies ([Zn2(L1)2(bipy)], 3 and [Zn2(L1)2(bpe)], 4, respectively)...
October 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28975665/crystal-structures-of-staphylococcus-aureus-ketol-acid-reductoisomerase-in-complex-with-two-transition-state-analogs-that-have-biocidal-activity
#19
Khushboo Patel, David Teran, Shan Zheng, Ajit Kandale, Mario Garcia, You Lv, Mark A Schembri, Ross P McGeary, Gerhard Schenk, Luke William Guddat
Ketol-acid reductoisomerase (KARI) is an NAD(P)H and Mg2+-dependent enzyme of the branched-chain amino acid (BCAA) biosynthesis pathway. Here we describe the first crystal structures of Staphylococcus aureus (Sa) KARI, these in complex with two transition state analogs, cyclopropane-1,1-dicarboxylate (CPD) and N-isopropyloxalyl hydroxamate (IpOHA). These compounds bind competitively and in multi-dentate manner to KARI with Ki values of 2.73 μM and 7.9 nM, respectively; however, IpOHA binds slowly to the enzyme...
October 4, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28957448/pilot-study-on-novel-blood-containers-with-alternative-plasticizers-for-red-cell-concentrate-storage
#20
Yuki Morishita, Yusuke Nomura, Chie Fukui, Tsuyoshi Kawakami, Toshiyuki Ikeda, Tomokazu Mukai, Toshiyasu Yuba, Ken-Ichi Inamura, Hisatoki Yamaoka, Ken-Ichi Miyazaki, Hitoshi Okazaki, Yuji Haishima
Di (2-ethylhexyl) phthalate (DEHP), a typical plasticizer used for polyvinyl chloride (PVC) blood containers, is eluted from the blood containers and exerts protective effects on red blood cells. However, a concern for detrimental effects of DEHP on human health has led to the development of potential DEHP substitutes. Here, we compared the red blood cell preservation ability of two types of non-DEHP blood containers with safe alternative plasticizers to that of DEHP blood containers. Red cell concentrates in mannitol-adenine-phosphate solution (MAP/RCC) were stored for 6 weeks in PVC blood bags containing DEHP, di-isononyl-cyclohexane-1,2-dicarboxylate (DINCH) and di (2-ethylhexyl) 4-cyclohexene-1,2-dicarboxylate (DOTH), or 4-cyclohexene-1,2-dicarboxylic acid dinonyl ester (DL9TH) and DOTH...
2017: PloS One
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