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https://www.readbyqxmd.com/read/29216425/replacing-the-ethylmalonyl-coa-pathway-with-the-glyoxylate-shunt-provides-metabolic-flexibility-in-the-central-carbon-metabolism-of-methylobacterium-extorquens-am1
#1
Lennart Schada von Borzyskowski, Frank Sonntag, Laura Pöschel, Julia Anne Vorholt, Jens Schrader, Tobias J Erb, Markus Buchhaupt
The ethylmalonyl-CoA pathway (EMCP) is an anaplerotic reaction sequence in the central carbon metabolism of numerous Proteo- and Actinobacteria. The pathway features several CoA-bound mono- and dicarboxylic acids that are of interest as platform chemicals for the chemical industry. The EMCP, however, is essential for growth on C1 and C2 carbon substrates and therefore cannot be simply interrupted to drain these intermediates. In this study, we aimed at reengineering central carbon metabolism of the Alphaproteobacterium Methylobacterium extorquens AM1 for the specific production of EMCP derivatives in the supernatant...
December 7, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29208505/toxicological-analysis-of-roast-duck-flavor-components
#2
Yiming Zhou, Beibei Yan, Shen Zhao, Xiaoli Zhou, Ying Xiao
The aim of the study was to investigate toxicity of the synthesized roast duck flavor through animal experiment (mice feeding with the flavor for 35 days), and the major toxic compounds (acrylamide and 3,4-benzopyrene) were detected by high performance liquid chromatography. Compared with the control group, the blood biochemical indexes including protein content, bilirubin content, activity of alkaline phosphatase, activity of aspartate transaminase (AST) and alanine transaminase (ALT), cholesterol content, high density lipoprotein (HDL) and low density lipoprotein (LDL) content, triglycerides content, activity of creatine kinase (CK) and CK-MB, activity of cholinesterase (CHE) and lactate dehydrogenase (LDH), total bile acid (TBA) in high dose feeding group were significantly different...
December 2, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29205812/cu2-modified-metal-organic-framework-nanoparticles-a-peroxidase-mimicking-nanoenzyme
#3
Wei-Hai Chen, Margarita Vázquez-González, Anna Kozell, Alessandro Cecconello, Itamar Willner
The synthesis and characterization of UiO-type metal-organic framework nanoparticles (NMOFs) composed of Zr4+ ions bridged by 2,2'-bipyridine-5,5'-dicarboxylic acid ligands and the postmodification of the NMOFs with Cu2+ ions are described. The resulting Cu2+ -modified NMOFs, Cu2+ -NMOFs, exhibit peroxidase-like catalytic activities reflected by the catalyzed oxidation of Amplex-Red to the fluorescent Resorufin by H2 O2 , the catalyzed oxidation of dopamine to aminochrome by H2 O2 , and the catalyzed generation of chemiluminescence in the presence of luminol/H2 O2 ...
December 4, 2017: Small
https://www.readbyqxmd.com/read/29205565/binding-profiles-of-self-assembled-supramolecular-cages-from-esi-ms-based-methodology
#4
Carlo Bravin, Elena Badetti, Rakesh Puttreddy, Fangfang Pan, Kari Rissanen, Giulia Licini, Cristiano Zonta
Confined molecular environments own peculiar characteristics that make their properties unique in the field of biological and chemical sciences. In recent years, the advancement of synthetic supramolecular capsules and cages have offered the possibility to interpret the principles behind their self-assembly and functions, leading to new molecular systems which display outstanding properties in molecular recognition and catalysis. Herein, we report a rapid method based on ESI-MS for the determination of binding profiles for linear saturated dicarboxylic acids within a series of different cages...
December 4, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29201559/genomic-characterization-of-a-new-endophytic-streptomyces-kebangsaanensis-identifies-biosynthetic-pathway-gene-clusters-for-novel-phenazine-antibiotic-production
#5
Juwairiah Remali, Nurul 'Izzah Mohd Sarmin, Chyan Leong Ng, John J L Tiong, Wan M Aizat, Loke Kok Keong, Noraziah Mohamad Zin
Background: Streptomyces are well known for their capability to produce many bioactive secondary metabolites with medical and industrial importance. Here we report a novel bioactive phenazine compound, 6-((2-hydroxy-4-methoxyphenoxy) carbonyl) phenazine-1-carboxylic acid (HCPCA) extracted from Streptomyces kebangsaanensis, an endophyte isolated from the ethnomedicinal Portulaca oleracea. Methods: The HCPCA chemical structure was determined using nuclear magnetic resonance spectroscopy...
2017: PeerJ
https://www.readbyqxmd.com/read/29199826/luminescent-3d-lanthanide-cadmium-heterometal-organic-frameworks-with-chemical-stability-and-selective-luminescent-sensing
#6
Ling Ding, Le-Hui Liu, Qing Shi, Yan-Qiong Sun, Yong-Jiang Wang, Yi-Ping Chen
Four novel three-dimensional (3D) 4d-4f heterometal-organic compounds, [LnCd2(Pbc)4(Meimdc)(H2O)]·3H2O (Ln = Eu, 1a; Tb, 1b; Sm, 1c; Dy, 1d) (HPbc = 4-(4-pyridinyl)benzoic acid; H3Meimdc = 2-methyl-1H-4,5-imidazole-dicarboxylic acid), have been successfully prepared by a hydrothermal method. All the compounds are isostructural and show three-dimensional microporous pillar-layered structures with uncoordinated carboxylate sites hung in the channels. Compound 1a possesses excellent chemical stability. The luminescent investigations show that compounds 1a, 1b, 1c, and 1d display the characteristic emission bands of Ln3+ ions...
December 4, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29197344/lactation-related-metabolic-mechanism-investigated-based-on-mammary-gland-metabolomics-and-4-biofluids-metabolomics-relationships-in-dairy-cows
#7
Hui-Zeng Sun, Kai Shi, Xue-Hui Wu, Ming-Yuan Xue, Zi-Hai Wei, Jian-Xin Liu, Hong-Yun Liu
BACKGROUND: Lactation is extremely important for dairy cows; however, the understanding of the underlying metabolic mechanisms is very limited. This study was conducted to investigate the inherent metabolic patterns during lactation using the overall biofluid metabolomics and the metabolic differences from non-lactation periods, as determined using partial tissue-metabolomics. We analyzed the metabolomic profiles of four biofluids (rumen fluid, serum, milk and urine) and their relationships in six mid-lactation Holstein cows and compared their mammary gland (MG) metabolomic profiles with those of six non-lactating cows by using gas chromatography-time of flight/mass spectrometry...
December 2, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29196893/high-yield-production-of-four-carbon-dicarboxylic-acids-by-metabolically-engineered-escherichia-coli
#8
Irene Martinez, Haijun Gao, George N Bennett, Ka-Yiu San
Several metabolic engineered Escherichia coli strains were constructed and evaluated for four-carbon dicarboxylic acid production. Fumarase A, fumarase B and fumarase C single, double and triple mutants were constructed in a ldhA adhE mutant background overexpressing the pyruvate carboxylase from Lactococcus lactis. All the mutants produced succinate as the main four-carbon (C4) dicarboxylic acid product when glucose was used as carbon source with the exception of the fumAC and the triple fumB fumAC deletion strains, where malate was the main C4-product with a yield of 0...
December 1, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29183696/isolation-of-5-hydroxymethylfurfural-biotransforming-bacteria-to-produce-2-5-furan-dicarboxylic-acid-in-algal-acid-hydrolysate
#9
Chu-Fang Yang, Ci-Ruei Huang
In dealing with lignocellulosic and algal biomass, thermal acid hydrolysis is an economical and efficient method. In this process, 5-hydroxy-methylfurfural (5-HMF) is formed unavoidably, which inhibits downstream reducing sugar fermentation. Fortunately, 5-HMF can be biotransformed into 2,5-furan-dicarboxylic acid (FDCA), the top 14 biomass platform molecules. Base on the connection between 5-HMF removal and FDCA production, microbes capable of biotransforming 5-HMF into FDCA are beneficial to raise biofuel yield and potential molecule production...
November 25, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29183110/hyaluronic-acid-based-ph-sensitive-polymer-modified-liposomes-for-cell-specific-intracellular-drug-delivery-systems
#10
Maiko Miyazaki, Eiji Yuba, Hiroshi Hayashi, Atsushi Harada, Kenji Kono
For the enhancement of therapeutic effects and reduction of side effects derived from anticancer drugs in cancer chemotherapy, it is imperative to develop drug delivery systems with cancer-specificity and controlled release function inside cancer cells. pH-Sensitive liposomes are useful as an intracellular drug delivery system because of their abilities to transfer their contents into the cell interior through fusion or destabilization of endosome, which has weakly acidic environment. We earlier reported liposomes modified with various types of pH-sensitive polymers based on synthetic polymers and biopolymers as vehicles for intracellular drug delivery systems...
November 28, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29180752/the-e-coli-dicarboxylic-acid-transporters-daua-act-as-a-signal-transducer-by-interacting-with-the-dcta-uptake-system
#11
Eleni Karinou, Paul A Hoskisson, Alexander Strecker, Gottfried Unden, Arnaud Javelle
The Slc26A/SulP family of ions transporter is ubiquitous and widpsread in all kingdon of life. In E. coli, we have demonstrated that the Slc26 protein DauA is a C4-dicarboxilic acids (C4-diC) transporter active at acidic pH. The main C4-diC transporter active at pH7 is DctA and is induced by C4-diC via the DcuS/R two component system. DctA interacts with DcuS, the membrane embedded histidine kinase, to transfers DcuS to the responsive state, i.e. in the absence of DctA, DcuS is permanently "on", but its activity is C4-diC-dependent when in complex with DctA...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29178323/diverse-structures-based-on-heptanuclear-co-cluster-from-0d-to-3d-metal-organic-framework-magnetism-and-application-in-batteries
#12
Bowen Qin, Kecheng Huang, Yu Zhang, Lei Zhou, Zheng Cui, Kuo Zhang, Xiaoying Zhang, Jingping Zhang
Polymetallic complexes with interesting multifunction have attracted extensive explorations. Induced by different anions of cobalt salts and solvents, five complexes CoII4CoIII3(H2L)3Cl5(MeOH) (1), [CoII4CoIII3(H2L)3(CH3COO)4(HCOO).H2O]n (2), [CoII4CoIII3(H2L)3(HCOO)4(NO3).2H2O]n (3), [CoII4CoIII3(H2L)3(BDA)(CH3COO)4.2H2O]n (4) and [CoII4CoIII3(H2L)3(IPA)(HCOO)3(DMF).H2O]n (5) (H6L = bis-tris propane; BDA = biphenyl-4,4'-dicarboxylic acid; IPA = isophthalic acid; DMF = N,N-dimethylformamide) based on heptanuclear {CoII4CoIII3} cluster with structures from 0D to 3D metal organic framework (MOF) have been solvothermally synthesized...
November 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29177292/tuning-the-luminescence-of-two-3d-4f-metal-organic-frameworks-for-the-fast-response-and-highly-selective-detection-of-aniline
#13
Ling Li, Ji-Yong Zou, Sheng-Yong You, Hong-Min Cui, Guo-Ping Zeng, Jian-Zhong Cui
Two 3D solvent-stable zinc(ii)-lanthanide(iii) heterometallic metal-organic frameworks (MOFs) {[(CH3)2NH2]2[Zn2Ln2(FDA)6(DMF)2]·2DMF}n [Ln = Eu (Zn-Eu) and Tb (Zn-Tb); H2FDA = furan-2,5-dicarboxylic acid] based on Zn2Ln2(COO)10 tetrametallic clusters and furan-2,5-dicarboxylic acid have been successfully synthesized. These MOFs can serve as luminescent sensors for the fast response and highly selective detection of aniline via luminescence quenching. More importantly, a linear correlation is observed between their luminescence and the low concentration of aniline and the detection limits of aniline are 7...
November 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29168620/simple-organic-salts-having-naphthalenediimide-ndi-core-displaying-multi-functional-properties-gelation-anti-cancer-and-semiconducting-properties
#14
Parthasarathi Dastidar, Rumana Parveen, Nabasmita Maity
Following a supramolecular synthon rationale a dicarboxylic acid derivative having naphthalenediimide (NDI) core namely bis-N-carboxymethyl naphthalenediimide (NDI-A) was reacted with n-alkyl amines having varying alkyl chain length to generate a new series of primary ammonium dicarboxylate (PAD) salts. Majority of the salts (~85%) were found to gel various polar solvents. The gels were characterized by dynamic rheology and high resolution electron microscopy. Single crystal and powder X-ray diffraction were employed to study the supramolecular synthon present in one of the gelator salts namely S8...
November 23, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29163455/designing-and-creating-a-synthetic-omega-oxidation-pathway-in-saccharomyces-cerevisiae-enables-production-of-medium-chain-%C3%AE-%C3%AF-dicarboxylic-acids
#15
Li Han, Yanfeng Peng, Yuangyuan Zhang, Wujiu Chen, Yuping Lin, Qinhong Wang
Medium-chain (C8-C14) α, ω-dicarboxylic acids (α, ω-DCAs), which have numerous applications as raw materials for producing various commodities and polymers in chemical industry, are mainly produced from chemical or microbial conversion of petroleum-derived alkanes or plant-derived fatty acids at present. Recently, significant attention has been gained to microbial production of medium-chain α, ω-DCAs from simple renewable sugars. Here, we designed and created a synthetic omega oxidation pathway in Saccharomyces cerevisiae to produce C10 and C12 α, ω-DCAs from renewable sugars and fatty acids by introducing a heterogeneous cytochrome P450 CYP94C1 and cytochrome reductase ATR1...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29162533/derivation-of-an-oral-reference-dose-rfd-for-di-2-ethylhexyl-cyclohexan-1-4-dicarboxylate-dehch-an-alternative-to-phthalate-plasticizers
#16
Brian J Hughes, Kevin Cox, Virunya Bhat
Di 2-ethylhexyl cyclohexane-1,4-dicarboxylate (DEHCH, CAS 84731-70-4) is an ester of polycarboxylic acid assessed in a wide variety of ecotoxicological and mammalian toxicity assays as a substitute for phthalate ester-type plasticizers. Laboratory animal data indicate that DEHCH has a low acute oral and dermal toxicity, is non-irritating to the skin and eyes, and is a non-sensitizer. In an OECD 422 combined repeat dose toxicity study with a reproductive/developmental toxicity screening test in Sprague-Dawley rats, minimal effects were observed on the liver, spleen, and thyroid...
November 18, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29155059/microbial-production-of-branched-chain-dicarboxylate-2-methylsuccinic-acid-via-enoate-reductase-mediated-bioreduction
#17
Jian Wang, Yaping Yang, Ruihua Zhang, Xiaolin Shen, Zhenya Chen, Jia Wang, Qipeng Yuan, Yajun Yan
2-Methylsuccinic acid (2-MSA) is a C5 branched-chain dicarboxylate that serves as an attractive synthon for the synthesis of polymers with extensive applications in coatings, cosmetic solvents and bioplastics. However, the lack of natural pathways for 2-MSA biosynthesis has limited its application as a promising bio-replacement. Herein, we conceived a non-natural three-step biosynthetic route for 2-MSA, via employing the citramalate pathway in combination with enoate reductase-mediated bioreduction of the pathway intermediate citraconate...
November 20, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/29147525/multi-component-hybrid-hydrogels-understanding-the-extent-of-orthogonal-assembly-and-its-impact-on-controlled-release
#18
Vânia M P Vieira, Laura L Hay, David K Smith
This paper reports self-assembled multi-component hybrid hydrogels including a range of nanoscale systems and characterizes the extent to which each component maintains its own unique functionality, demonstrating that multi-functionality can be achieved by simply mixing carefully-chosen constituents. Specifically, the individual components are: (i) pH-activated low-molecular-weight gelator (LMWG) 1,3;2,4-dibenzylidenesorbitol-4',4''-dicarboxylic acid (DBS-COOH), (ii) thermally-activated polymer gelator (PG) agarose, (iii) anionic biopolymer heparin, and (iv) cationic self-assembled multivalent (SAMul) micelles capable of binding heparin...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29147516/a-new-route-to-n-aromatic-heterocycles-from-the-hydrogenation-of-diesters-in-the-presence-of-anilines
#19
Yiping Shi, Paul C J Kamer, David J Cole-Hamilton, Michelle Harvie, Emma F Baxter, Kate J C Lim, Peter Pogorzelec
The hydrogenation of dicarboxylic acids and their esters in the presence of anilines provides a new synthesis of heterocycles. [Ru(acac)3] and 1,1,1-tris(diphenylphosphinomethyl)ethane (triphos) gave good to excellent yields of the cyclic amines at 220 °C. When aqueous ammonia was used with dimethyl 1,6-hexadienoic acid, ε-caprolactam was obtained in good yield. A side reaction involving alkylation of the amine by methanol was suppressed by using diesters derived from longer chain and branched alcohols. Hydrogenation of optically pure diesters (dimethyl (R)-2-methylbutanedioate and dimethyl (S)-2-methylbutanedioate) with aniline afforded racemic 3-methyl-1-phenylpyrrolidine in 78% yield...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29142974/profiling-of-plasma-metabolites-suggests-altered-mitochondrial-fuel-usage-and-remodeling-of-sphingolipid-metabolism-in-individuals-with-type%C3%A2-2-diabetes-and-kidney-disease
#20
Jian-Jun Liu, Sujoy Ghosh, Jean-Paul Kovalik, Jianhong Ching, Hyung Won Choi, Subramaniam Tavintharan, Choon Nam Ong, Chee Fang Sum, Scott A Summers, E Shyong Tai, Su Chi Lim
Introduction: Pathophysiology of diabetic kidney disease (DKD) is incompletely understood. We aim to elucidate metabolic abnormalities associated with DKD in type 2 diabetes mellitus (T2DM) by targeted plasma metabolomics. Methods: A total of 126 T2DM participants with early DKD (urinary albumin-to-creatinine ratio [ACR] 30-299 mg/g and eGFR ≥ 60 ml/min/1.73 m(2)), 154 overt DKD (ACR ≥ 300 mg/g or eGFR < 60 ml/min/1.73 m(2)), and 129 non-DKD T2DM controls (ACR < 30 mg/g and eGFR ≥ 60 ml/min/1...
May 2017: KI Reports
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