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https://www.readbyqxmd.com/read/29474840/production-of-muconic-acid-in-plants
#1
Aymerick Eudes, Roland Berthomieu, Zhangying Hao, Nanxia Zhao, Veronica Teixeira Benites, Edward E K Baidoo, Dominique Loqué
Muconic acid (MA) is a dicarboxylic acid used for the production of industrially relevant chemicals such as adipic acid, terephthalic acid, and caprolactam. Because the synthesis of these polymer precursors generates toxic intermediates by utilizing petroleum-derived chemicals and corrosive catalysts, the development of alternative strategies for the bio-based production of MA has garnered significant interest. Plants produce organic carbon skeletons by harvesting carbon dioxide and energy from the sun, and therefore represent advantageous hosts for engineered metabolic pathways towards the manufacturing of chemicals...
February 20, 2018: Metabolic Engineering
https://www.readbyqxmd.com/read/29470069/photochemistry-of-fac-re-co-3-dcbh-2-trans-stpy-new-insights-on-the-isomerization-mechanism-of-coordinated-stilbene-like-ligands
#2
Leandro A Faustino, Antonio Eduardo Hora Machado, Antonio Otavio T Patrocinio
In this work, a novel complex fac-[Re(CO)3 (dcbH2 )(trans-stpy)]+ , (dcbH2 = 4,4'-dicarboxylic acid-2,2'-bipyridine; trans-stpy = trans-4-styrylpyridine) was synthesized and characterized toward its spectroscopic, photochemical, and photophysical properties. The experimental data provide new insights on the mechanism of photochemical trans-to-cis isomerization of the stilbene-like ligand coordinated to Re(I) polypyridyl complexes. The new complex exhibits an unusual and strong dependence of the isomerization quantum yield (Φt→c ) on the irradiation wavelength...
February 22, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29465993/series-of-highly-stable-lanthanide-organic-frameworks-constructed-by-a-bifunctional-linker-synthesis-crystal-structures-and-magnetic-and-luminescence-properties
#3
Dong Peng, Lei Yin, Peng Hu, Bao Li, Zhong-Wen Ouyang, Gui-Lin Zhuang, Zhenxing Wang
By utilizing a preselected functional ligand produced by 1H-imidazole-4,5-dicarboxylic acid, three isostructural lanthanide coordination polymers (CPs), denoted as {[Ln2 (OH)2 (L)2 ]·(DMF)·(H2 O)4 }n (Ln = Gd (1), Eu (2), Dy (3); L = 1-(4-carboxybenzyl)imidazole-4-carboxylic acid), containing a 1D infinite [Ln4 (OH)4 ] subchain have been successfully constructed. The highly connected mode between the multifunctional ligand and 1D building units is responsible for the exceptional chemical stability of three lanthanide CPs...
February 21, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29465130/targeted-vegf-triggered-release-of-an-anti-cancer-drug-from-aptamer-functionalized-metal-organic-framework-nanoparticles
#4
Wei-Hai Chen, Sohn Yang Sung, Michael Fadeev, Alessandro Cecconello, Rachel Nechushtai, Itamar Willner
Amino-triphenyl dicarboxylate-bridged Zr4+ metal-organic framework nanoparticles (NMOFs), 100-130 nm, are modified with a nucleic acid complementary to the VEGF aptamer. The nucleic acid-functionalized NMOFs were loaded with the anti-cancer drug doxorubicin (or Rhodamine 6G as a drug model), and the loaded NMOFs were capped by hybridization with the VEGF aptamer that yielded VEGF-responsive duplex nucleic acid gates. In the presence of VEGF, a biomarker over-expressed in cancer cells, selective unlocking of the gates proceeds through the formation of VEGF/aptamer complexes, resulting in the release of the loads...
February 21, 2018: Nanoscale
https://www.readbyqxmd.com/read/29462757/unveiling-the-ph-dependent-interaction-between-bolaamphiphiles-dicarboxylic-acids-and-c-10-tab-decyltrimethylammonium-bromide-in-aqueous-medium
#5
Animesh Pan, Subhash C Bhattacharya, Animesh K Rakshit, Satya P Moulik
Development of stable self-assembled nanostructures (especially vesicles and liposomes), and understanding their physicochemical behaviors in aqueous solution is a long-standing topic of interest in chemical and biochemical research. In this progressive area, we report for the first-time formation of mixed micelles (at pH 12), and vesicles of anionic bolaamphiphiles (dicarboxylic acids viz. [Formula: see text] , with moderate values of n 10, 11, 12, and 14) in combination with a cationic surfactant decyltrimethylammonium bromide (C10 TAB) in buffered aqueous medium at different pH (6...
February 8, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29451571/sea-spray-aerosol-chemical-composition-elemental-and-molecular-mimics-for-laboratory-studies-of-heterogeneous-and-multiphase-reactions
#6
REVIEW
Timothy H Bertram, Richard E Cochran, Vicki H Grassian, Elizabeth A Stone
Sea spray aerosol particles (SSA), formed through wave breaking at the ocean surface, contribute to natural aerosol particle concentrations in remote regions of Earth's atmosphere, and alter the direct and indirect effects of aerosol particles on Earth's radiation budget. In addition, sea spray aerosol serves as suspended surface area that can catalyze trace gas reactions. It has been shown repeatedly that sea spray aerosol is heavily enriched in organic material compared to the surface ocean. The selective enrichment of organic material complicates the selection of representative molecular mimics of SSA for laboratory or computational studies...
February 16, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29441347/pyridine-2-4-dicarboxylic-acid-suppresses-tomato-seedling-growth
#7
Sotirios Fragkostefanakis, Dimitrios Kaloudas, Panagiotis Kalaitzis
Pyridine 2,4-dicarboxylic acid is a structural analog of 2-oxoglutarate and is known to inhibit 2-oxoglutare-dependent dioxygenases. The effect of this inhibitor in tomato seedlings grown in MS media supplied with various concentrations of PDCA was investigated, resulting in shorter roots and hypocotyls in a dose-dependent manner. The partial inhibition of growth in roots was more drastic compared to hypocotyls and was attributed to a decrease in the elongation of root and hypocotyl cells. Concentrations of 100 and 250 μM of PDCA decreased hydroxyproline content in roots while only the 250 μM treatment reduced the hydroxyproline content in shoots...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29439261/metabolomics-reveals-protection-of-resveratrol-in-diet-induced-metabolic-risk-factors-in-abdominal-muscle
#8
Guoyou Chen, Guozhu Ye, Xinbo Zhang, Xiaoxiao Liu, Yingfeng Tu, Zengjie Ye, Jincheng Liu, Qi Guo, Zhiguo Wang, Lin Wang, Sijun Dong, Yuhua Fan
BACKGROUND/AIMS: Abdominal obesity is recognized as the main reason of metabolic syndrome, which is closely related to disordered skeletal and/or abdominal muscle metabolic functions. Metabolomics is a comprehensive assessment system in biological metabolites. The aim of our present study is to investigate the diet-induced metabolic risk factors by metabolic in the abdominal muscles and clarify the relationship between atheroprotective effects of Resveratrol (Rev) and abdominal muscles metabolic components during the development of atherosclerosis...
February 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29436006/endogenous-purines-modulate-k-evoked-ach-secretion-at-the-mouse-neuromuscular-junction
#9
Juan F Guarracino, Alejandro R Cinalli, Mariela I Veggetti, Adriana S Losavio
At the mouse neuromuscular junction, adenosine triphosphate (ATP) is co-released with the neurotransmitter acetylcholine (ACh), and once in the synaptic cleft, it is hydrolyzed to adenosine. Both ATP/adenosine diphosphate (ADP) and adenosine modulate ACh secretion by activating presynaptic P2Y13 and A1 , A2A , and A3 receptors, respectively. To elucidate the action of endogenous purines on K+ -dependent ACh release, we studied the effect of purinergic receptor antagonists on miniature end-plate potential (MEPP) frequency in phrenic diaphragm preparations...
February 13, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29431809/lanthanide-mofs-constructed-from-mixed-dicarboxylate-ligands-as-selective-multi-responsive-luminescent-sensors
#10
Xiaolei Zhang, Zhiying Zhan, Xiaoyu Liang, Chen Chen, Xiaoli Liu, YueJiao Jia, Ming Hu
Five novel Ln-MOFs associated with the mixed ligands of 4-(pyridin-3-yloxy)-phthalic acid (H2ppda) and terephthalic acid (H2bdc), namely, [Ln(ppda)(bdc)0.5(C2H5OH)(H2O)]n (Ln = Sm (1), Eu (2), Gd (3), Tb (4), and Dy (5)) were synthesized under the solvothermal conditions. Compounds 1-5 exhibit the isostructural 2D layered structures. The solid-state luminescence properties of compounds 1, 2, 4 and 5 were investigated in detail. It was found that compound 4 not only detected nitrobenzene derivatives-based explosives with high selectivity, sensitivity, and recyclability, but also served as an excellent selective sensing material for Fe3+ ion and Cr2O72- ion...
February 12, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29429706/ultrasound-assisted-synthesis-of-zinc-ii-based-metal-organic-framework-nanoparticles-in-the-presence-of-modulator-for-adsorption-enhancement-of-2-4-dichlorophenol-and-amoxicillin
#11
Reza Abazari, Ali Reza Mahjoub
In this study, under a sonochemical method, a 3D, porous Zn(II)-based metal-organic framework [Zn(TDC)(4-BPMH)]n·n(H2O) is produced, which is called compound 1. To this end, the dicarboxylate linker of TDC, (2,5-thiophene dicarboxylic acid) and the pillar spacer of 4-BPMH, (N,N-bis-pyridin-4-ylmethylene-hydrazine) were employed. Moreover, variations in the morphology and growth of the micro/nanoparticles of compound 1 were investigated in terms of the effect of temperature, ultrasound irradiation power, sonication time, initial reagent concentrations, and pyridine concentration as a modulator...
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29429661/sonochemical-synthesis-of-a-new-nano-sized-barium-coordination-polymer-and-its-application-as-a-heterogeneous-catalyst-towards-sono-synthesis-of-biodiesel
#12
Faezeh Moghzi, Janet Soleimannejad
A new nano-sized barium coordination polymer, {(bipyH)[Ba2(pydc)2(Hpydc)(H2O)2]}n·nH2O (1), (bipy = 4,4'-bipyridine and H2pydc = pyridine-2,6-dicarboxylic acid), has been sonochemically synthesized and fully characterized by scanning electron microscopy (SEM), X-ray powder diffraction (XRPD), FT-IR spectroscopy, thermogravimetric analysis (TGA) and elemental analyses. Compound 1 was structurally characterized by single crystal X-ray diffraction and it was shown that this compound consists of 1D anionic coordination polymers and bipyH+ cationic species that construct a three-dimensional supramolecular architecture via non-covalent interactions i...
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29429653/sonochemically-synthesized-blue-fluorescent-functionalized-graphene-oxide-as-a-drug-delivery-system
#13
Hamed Hashemi, Hassan Namazi
Ultrasound assisted the copper-catalyzed cross-coupling reaction to synthesis 1-(10-bromoanthracene-9-yl)-1H-imidazole-4,5-dicarboxylic acid (A-Im). The obtained product was employed to modify graphene oxide (GO) surface to produce GO-A-Im. The resulted hybrid was characterized with Scanning Electron Microscope (SEM/EDS); X-ray Diffraction spectroscopy (XRD); X-ray photoelectron spectroscopy (XPS); Fluorescence spectroscopy; Fourier transformed infrared spectroscopy (FT-IR), Brunauer-Emmett-Teller (BET), and UV-Vis absorption spectroscopy...
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29425657/urine-metabolomics-shows-an-induction-of-fatty-acids-metabolism-in-healthy-adult-volunteers-after-supplementation-with-green-coffee-coffea-robusta-l-bean-extract
#14
Gregorio Peron, Davide Santarossa, Dario Voinovich, Stefano Dall'Acqua, Stefania Sut
BACKGROUND AND OBJECTIVE: Green coffee bean extract is used as herbal medicine or supplement for weight reduction and obesity. The active constituents are considered caffeine and chlorogenic acid (CGA) derivatives. The mode of action of CGA is still unclear and can be related to peroxisome proliferator-activated receptor α (PPAR-α) and liver X receptor Rα (LXR-α). Metabolomics may be an innovative tool for the description and discovery of the multiple target nature of such phytocomplex...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29421333/the-urinary-metabolites-of-dinch%C3%A2-have-an-impact-on-the-activities-of-the-human-nuclear-receptors-er%C3%AE-er%C3%AE-ar-ppar%C3%AE-and-ppar%C3%AE
#15
Anika Engel, Thorsten Buhrke, Stefanie Kasper, Anne-Cathrin Behr, Albert Braeuning, Sönke Jessel, Albrecht Seidel, Wolfgang Völkel, Alfonso Lampen
DINCH® (di-isononyl cyclohexane-1,2-dicarboxylate) is a non-phthalate plasticizer that has been developed to replace phthalate plasticizers such as DEHP (di-2-ethylhexyl phthalate) or DINP (di-isononyl phthalate). DINCH® is metabolized to its corresponding monoester and subsequently to oxidized monoester derivatives. These are conjugated to glucuronic acid and subject to urinary excretion. In contrast to DINCH®, there are almost no toxicological data available regarding its primary and secondary metabolites...
February 5, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29412460/revisiting-the-mechanism-of-hydrolysis-of-betanin
#16
Larissa C Esteves, Amanda C Pinheiro, Renan M Pioli, Tatiana C Penna, Wilhelm J Baader, Thiago C Correra, Erick L Bastos
Betanin (betanidin 5-O-β-D-glucoside) is a water-soluble plant pigment used as a color additive in food, drugs and cosmetic products. Despite its sensitivity to light and heat, betanin maintains appreciable tinctorial strength in low acidic and neutral conditions, where the color of other plant pigments, such as anthocyanins, quickly fades. However, betanin is an iminium natural product that experience acid- and base-catalyzed hydrolysis to form the fairly stable betalamic acid and cyclo-DOPA-5-O-β-D-glucoside...
February 7, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29395960/application-of-microalgae-hydrolysate-as-a-fermentation-medium-for-microbial-production-of-2-pyrone-4-6-dicarboxylic-acid
#17
April N Htet, Mana Noguchi, Kazuaki Ninomiya, Yota Tsuge, Kosuke Kuroda, Shinya Kajita, Eiji Masai, Yoshihiro Katayama, Kazuhiro Shikinaka, Yuichiro Otsuka, Masaya Nakamura, Ryo Honda, Kenji Takahashi
Actual biomass of microalgae was tested as a fermentation substrate for microbial production of 2-pyrone 4,6-dicarboxylic acid (PDC). Acid-hydrolyzed green microalgae Chlorella emersonii (algae hydrolysate) was diluted to adjust the glucose concentration to 2 g/L and supplemented with the nutrients of Luria-Bertani (LB) medium (tryptone 10 g/L and yeast extract 5 g/L). When the algae hydrolysate was used as a fermentation source for recombinant Escherichia coli producing PDC, 0.43 g/L PDC was produced with a yield of 20...
January 29, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29395959/identification-of-eayjjpb-encoding-a-dicarboxylate-transporter-important-for-succinate-production-under-aerobic-and-anaerobic-conditions-in-enterobacter-aerogenes
#18
Keita Fukui, Kei Nanatani, Yoshihiko Hara, Mitsunori Tokura, Keietsu Abe
Enterobacter aerogenes, a gram-negative, rod-shaped bacterium, is an effective producer of succinate from glucose via the reductive tricarboxylic acid cycle under anaerobic conditions. However, to date, succinate-exporter genes have not been identified in E. aerogenes, although succinate exporters have a large impact on fermentative succinate production. Recently, we genetically identified yjjP and yjjB, as genes encoding a succinate transporter in Escherichia coli. Evaluation of the yjjPB homologs in E. aerogenes (EayjjPB genes) showed that succinate accumulation increased from 4...
January 30, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29392206/reduced-intraepidermal-nerve-fiber-density-after-a-sustained-increase-in-insular-glutamate-a-proof-of-concept-study-examining-the-pathogenesis-of-small-fiber-pathology-in-fibromyalgia
#19
Steven E Harte, Daniel J Clauw, John M Hayes, Eva L Feldman, Irene C St Charles, Christopher J Watson
Introduction: Neuroimaging reveals increased glutamate within the insula of patients with fibromyalgia (FM), suggesting a link between FM symptoms and increased central excitatory neurotransmission. Many patients with FM also present with decreased intraepidermal nerve fiber density (IENFD), consistent with small fiber pathology. It remains unknown, however, whether either of these mechanistic findings represent a cause or a consequence of the other. This study tests the hypothesis that an excitatory imbalance within the insula leads to small fiber pathology...
May 2017: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29391435/the-activity-of-the-c4-dicarboxylic-acid-chemoreceptor-of-pseudomonas-aeruginosa-is-controlled-by-chemoattractants-and-antagonists
#20
David Martín-Mora, Álvaro Ortega, Francisco J Pérez-Maldonado, Tino Krell, Miguel A Matilla
Chemotaxis toward organic acids has been associated with colonization fitness and virulence and the opportunistic pathogen Pseudomonas aeruginosa exhibits taxis toward several tricarboxylic acid intermediates. In this study, we used high-throughput ligand screening and isothermal titration calorimetry to demonstrate that the ligand binding domain (LBD) of the chemoreceptor PA2652 directly recognizes five C4-dicarboxylic acids with KD values ranging from 23 µM to 1.24 mM. In vivo experimentation showed that three of the identified ligands act as chemoattractants whereas two of them behave as antagonists by inhibiting the downstream chemotaxis signalling cascade...
February 1, 2018: Scientific Reports
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