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https://www.readbyqxmd.com/read/28510429/copolymerization-of-carbon-dioxide-with-epoxides-catalyzed-by-structurally-well-characterized-dinickel-bis-benzotriazole-iminophenolate-complexes-influence-of-carboxylate-ligands-on-the-catalytic-performance
#1
Li-Shin Huang, Chen-Yen Tsai, Hui-Ju Chuang, Bao-Tsan Ko
A series of structurally well-defined dinickel carboxylate complexes based on the (R)BiIBTP derivatives [(R)BiIBTP = bis(benzotriazole iminophenolate), where R = 3C for the propyl-bridged backbone and 5C for the 2,2-dimethyl-1,3-propyl-bridged backbone] were synthesized and developed for copolymerization of CO2 and epoxides. The one-pot reactions of nickel perchlorate with the (R)BiIBTP-H2 proligands and an appropriate amount of carboxylic acid derivatives (CF3COOH or 4-X-C6H4CO2H; X = H, CF3, OMe) upon the addition of triethylamine in refluxing methanol (MeOH) afforded dinuclear nickel dicarboxylate complexes, which could be formulated as either [((R)BiIBTP)Ni2(O2CCF3)2] (1 and 2) or [((R)BiIBTP)Ni2(O2CC6H4-4-X)2] (3-7)...
May 16, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28506930/rewiring-the-reductive-tricarboxylic-acid-pathway-and-l-malate-transport-pathway-of-aspergillus-oryzae-for-overproduction-of-l-malate
#2
Jingjing Liu, Zhipeng Xie, Hyun-Dong Shin, Jianghua Li, Guocheng Du, Jian Chen, Long Liu
Aspergillus oryzae finds wide application in the food, feed, and wine industries, and is an excellent cell factory platform for production of organic acids. In this work, we achieved the overproduction of L-malate by rewiring the reductive tricarboxylic acid (rTCA) pathway and L-malate transport pathway of A. oryzae NRRL 3488. First, overexpression of native pyruvate carboxylase and malate dehydrogenase in the rTCA pathway improved the L-malate titer from 26.1gL(-1) to 42.3gL(-1) in shake flask culture. Then, the oxaloacetate anaplerotic reaction was constructed by heterologous expression of phosphoenolpyruvate carboxykinase and phosphoenolpyruvate carboxylase from Escherichia coli, increasing the L-malate titer to 58...
May 12, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28502424/redox-speciation-of-iron-manganese-and-copper-in-cerebrospinal-fluid-by-strong-cation-exchange-chromatography-sector-field-inductively-coupled-plasma-mass-spectrometry
#3
Nikolay Solovyev, Marco Vinceti, Peter Grill, Jessica Mandrioli, Bernhard Michalke
A new method of simultaneous redox speciation of iron (II/III), manganese (II/III), and copper (I/II) in cerebrospinal fluid (CSF) has been designed. For the separation of redox species strong cation exchange chromatography (SCX) with isocratic elution was employed. Species were detected using inductively coupled plasma sector field mass spectrometry (ICP-sf-MS), operating at medium resolution. The following parameters were optimized: analytical column, eluent composition and pH, CSF injection volume and dilution factor...
June 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28500731/alternative-plasticizer-4-cyclohexene-1-2-dicarboxylic-acid-dinonyl-ester-for-blood-containers-with-protective-effects-on-red-blood-cells-and-improved-cold-resistance
#4
Yuki Morishita, Yusuke Nomura, Chie Fukui, Ayano Fujisawa, Kayo Watanabe, Hideo Fujimaki, Hidefumi Kumada, Kaoru Inoue, Tomomi Morikawa, Miwa Takahashi, Tsuyoshi Kawakami, Hideyuki Sakoda, Tomokazu Mukai, Toshiyasu Yuba, Ken-Ichi Inamura, Akito Tanoue, Ken-Ichi Miyazaki, Ung-Il Chung, Kumiko Ogawa, Midori Yoshida, Yuji Haishima
Di (2-ethylhexyl) phthalate (DEHP), a typical plasticizer used for polyvinyl chloride (PVC), is eluted from PVC-made blood containers and protects against red blood cell (RBC) hemolysis. However, concerns have arisen regarding the reproductive and developmental risks of DEHP in humans, and the use of alternative plasticizers for medical devices has been recommended worldwide. In this study, we propose that the use of a novel plasticizer, 4-cyclohexene-1,2-dicarboxylic acid dinonyl ester (DL9TH), could help produce more useful and safe blood containers...
May 13, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28495892/lux-bacterial-biosensors-for-in-vivo-spatiotemporal-mapping-of-root-secretion
#5
Francesco Pini, Alison K East, Corinne Appia-Ayme, Jakub Tomek, Ramakrishnan Karunakaran, Marcela Mendoza-Suarez, Anne Edwards, Jason Terpolilli, Joshua Rowoth, J Allan Downie, Phil Poole
Plants engineer the rhizosphere to their advantage by secreting various nutrients and secondary metabolites. Coupling transcriptomic and metabolomic analysis of the Pisum sativum rhizosphere, a suite of bioreporters has been developed in Rhizobium leguminosarum bv. viciae 3841, and these detect metabolites secreted by roots in space and time. Fourteen bacterial lux-fusion bioreporters, specific for sugars, polyols, amino acids, organic acids or flavonoids, have been validated in vitro and in vivo. Using different bacterial mutants (nodC, nifH), the process of colonization and symbiosis has been analyzed, revealing compounds important in the different steps of the rhizobial-legume association...
May 11, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28495581/dipicolinic-acid-as-a-novel-spore-inspired-excipient-for-antibody-formulation
#6
Iris L Batalha, Peng Ke, Esther Tejeda-Montes, Shahid Uddin, Christopher F van der Walle, Graham Christie
Ionic excipients are commonly used in aqueous therapeutic monoclonal antibody (mAb) formulations. Novel excipients are of industrial interest, with a recent focus on Arg salt forms and their application as viscosity reducing and stabilizing additives. Here, we report that the calcium salt of dipicolinic acid (DPA, pyridine-2,6-dicarboxylic acid), uniquely present in nature in the core of certain bacterial spores, reduces the viscosity of a mAb formulated at 150mg/mL, below that achieved by Arg hydrochloride at the same concentration (10mM)...
May 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28486802/synthesis-and-characterization-of-diol-based-unsaturated-polyesters-poly-diol-fumarate-and-poly-diol-fumarate-co-succinate
#7
Alexander M Tatara, Emma Watson, Tejus Satish, David W Scott, Dimitrios P Kontoyiannis, Paul S Engel, Antonios G Mikos
In this work, we describe the synthesis and characterization of variants of poly(diol fumarate) and poly(diol fumarate-co-succinate). Through a Fischer esterification, α,ω-diols and dicarboxylic acids were polymerized to form aliphatic polyester comacromers. Because of the carbon-carbon double bond of fumaric acid, incorporating it into the macromer backbone structure resulted in unsaturated chains. By choosing α,ω-diols of different lengths (1,6-hexanediol, 1,8-octanediol, and 1,10-decanediol) and controlling the amount of fumaric acid in the dicarboxylic acid monomer feed (33, 50, and 100 mol %), nine diol-based macromer variants were synthesized and characterized for molecular weight, number of unsaturated bonds per chain, and thermal properties...
May 17, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28485254/high-dietary-arachidonic-acid-levels-induce-changes-in-complex-lipids-and-immune-related-eicosanoids-and-increase-levels-of-oxidised-metabolites-in-zebrafish-danio-rerio
#8
Anne-Catrin Adam, Kai K Lie, Mari Moren, Kaja H Skjærven
This study explores the effect of high dietary arachidonic acid (ARA) levels (high ARA) compared with low dietary ARA levels (control) on the general metabolism using zebrafish as the model organism. The fatty acid composition of today's 'modern diet' tends towards higher n-6 PUFA levels in relation to n-3 PUFA. Low dietary n-3:n-6 PUFA ratio is a health concern, as n-6 PUFA give rise to eicosanoids and PG, which are traditionally considered pro-inflammatory, especially when derived from ARA. Juvenile zebrafish fed a high-ARA diet for 17 d had a lower whole-body n-3:n-6 PUFA ratio compared with zebrafish fed a low-ARA (control) diet (0·6 in the control group v...
May 9, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28480463/green-and-rapid-synthesis-of-zirconium-metal-organic-frameworks-via-mechanochemistry-uio-66-analog-nanocrystals-obtained-in-one-hundred-seconds
#9
Yi-Hao Huang, Wei-Shang Lo, Yun-Wei Kuo, Wen-Jin Chen, Chia-Her Lin, Fa-Kuen Shieh
A UiO-66 analog was synthesized in 100 s using water-assisted grinding. The linker solubility suggested that tetrafluorobenzene-1,4-dicarboxylic acid was the best linker. Zr-metal-organic framework nanocrystals displayed good topologies and hydrophobicities, and high water/thermal stabilities. The less amorphous complex led to higher porosities and pore volumes with a 60 min grinding time.
May 8, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28476407/curcumin-improves-alcoholic-fatty-liver-by-inhibiting-fatty-acid-biosynthesis
#10
Chang Guo, Jingfan Ma, Qionghong Zhong, Mengyuan Zhao, Tianxing Hu, Tong Chen, Longxin Qiu, Longping Wen
Alcoholic fatty liver is a threat to human health. It has been long known that abstinence from alcohol is the most effective therapy, other effective therapies are not available for the treatment in humans. Curcumin has a great potential for anti-oxidation and anti-inflammation, but the effect on metabolic reconstruction remains little known. Here we performed metabolomic analysis by gas chromatography/mass spectrometry and explored ethanol pathogenic insight as well as curcumin action pattern. We identified seventy-one metabolites in mouse liver...
May 2, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28472780/effects-of-microrna-19b-on-airway-remodeling-airway-inflammation-and-degree-of-oxidative-stress-by-targeting-tslp-through-the-stat3-signaling-pathway-in-a-mouse-model-of-asthma
#11
Ling Ye, Yan Mou, Jian Wang, Mei-Ling Jin
This study explored the effects of microRNA-19b (miR-19b) on airway remodeling, airway inflammation, and degree of oxidative stress in a mouse model of asthma. Bioinformatics analyses and dual luciferase reporter gene assays revealed that thymic stromal lymphopoietin (TSLP) is a direct target of miR-19b. An asthma model was established via ovalbumin (OVA) sensitization and challenge in 72 female BALB/c mice. Mice were then assigned to saline, OVA-sensitized, saline+miR-19b mimics, saline+anti-TSLP, OVA-sensitized+miR-19b mimics, OVA-sensitized+mimics scramble, OVA-sensitized+anti-TSLP, and OVA-sensitized+IgG2a groups...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28472549/chain-multiplication-of-fatty-acids-to-precise-telechelic-polyethylene
#12
Timo Witt, Manuel Häußler, Stefanie Kulpa, Stefan Mecking
We reveal a novel strategy starting from common monounsaturated fatty acids that provides ultra long aliphatic α,ω-difunctional building blocks by a sequence of two scalable catalytic steps that virtually double the starting materials' chain length. The central double bond of the well-known α,ω-dicarboxylic self-metathesis products of fatty acid is shifted selectively to the statistically much disfavored α,β-position in a catalytic dynamic isomerizing crystallization approach. 'Chain Doubling' via a subsequent catalytic olefin metathesis step that overcomes this substrates' low reactivity by using waste internal olefins as recyclable co-reagents yields ultra long-chain α,ω-difunctional building blocks of a precise chain length, as demonstrated up to a C48 chain...
May 4, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28467070/studies-of-carbon-monoxide-release-from-ruthenium-ii-bipyridine-carbonyl-complexes-upon-uv-light-exposure
#13
Manja Kubeil, Robbin R Vernooij, Clemens Kubeil, Bayden R Wood, Bim Graham, Holger Stephan, Leone Spiccia
The UV-light-induced CO release characteristics of a series of ruthenium(II) carbonyl complexes of the form trans-Cl[RuLCl2(CO)2] (L = 4,4'-dimethyl-2,2'-bipyridine, 4'-methyl-2,2'-bipyridine-4-carboxylic acid, or 2,2'-bipyridine-4,4'-dicarboxylic acid) have been elucidated using a combination of UV-vis absorbance and Fourier transform infrared spectroscopies, multivariate curve resolution alternating least-squares analysis, and density functional theory calculations. In acetonitrile, photolysis appears to proceed via a serial three-step mechanism involving the sequential formation of [RuL(CO)(CH3CN)Cl2], [RuL(CH3CN)2Cl2], and [RuL(CH3CN)3Cl](+)...
May 3, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28465213/metabolomic-changes-and-metabolic-responses-to-expression-of-heterologous-biosynthetic-genes-for-lycopene-production-in-yarrowia-lipolytica
#14
Chen Zhao, Qi Gao, Jun Chen, Liujing Wei, Tadayuki Imanaka, Qiang Hua
The metabolomic studies were conducted for both the engineered lycopene-producing Yarrowia lipolytica strain and the control strain. The changes in metabolome profiling and main pathway abundance of Y. lipolytica with the introduction of heterologous crt genes were investigated by multiple analytical and statistical methods More importantly, the metabolome data were transformed into pathway abundances visualized by a pathway relationship network using Cytoscape software. This network provided a simple way to present the statistical results of pathway abundance and interpret the effects of the crt genes in a metabolic view, and the results highlighted the up-regulation of eight pathways and the down-regulation of three pathways in the lycopene fast production phase...
April 29, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28458233/raman-and-drift-spectra-vibrational-assignments-and-quantum-mechanical-calculations-of-centrosymmetric-meso-2-3-dimercaptosuccinic-acid
#15
Ibrahim A Shaaban, Abdalla Karoyo, Lee D Wilson, Tarek A Mohamed
The Raman spectrum (3700-100cm(-1)) of meso-2,3-Dimercaptosuccinic acid (meso-DMSA; C4H6O4S2) was recorded in the solid phase using 514.5 and 785nm excitation lines. Whereas, the DRIFT spectrum (4000-400cm(-1)) of the sample powdered in KBr was obtained. Moreover, DFT-B3LYP/6-31G(d) geometry optimization and frequency calculations were carried out for centrosymmetric trans (Ci), gauche (C1; G(+)/G(-)) and eclipsed (Cs; Ef and C1; E(+)/E(-)) rotational isomers in favor of a trans conformation, the least energy with real frequencies...
April 18, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28451837/high-level-productivity-of-%C3%AE-%C3%AF-dodecanedioic-acid-with-a-newly-isolated-candida-viswanathii-strain
#16
Weifeng Cao, Hongbao Li, Jianquan Luo, Junxiang Yin, Yinhua Wan
α,ω-Dicarboxylic acids (DC) are versatile chemical intermediates with different chain lengths, which are well-known as polymer building block. In this work, a new strain with high productivity of DC was isolated from oil-contaminated soil. Based on the morphology and phylogenetic analyses of the internal transcribed spacer sequences, it was characterized as Candida viswanathii. It was found that the contribution of carbon flux to the cell growth and DC production from n-dodecane could be regulated by the sucrose and yeast extract concentrations in the medium, and besides the broth pH, a suitable proportioning of sucrose and yeast extract was the key to achieve the optimal transition from cell growth phase to DC production phase...
April 27, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28442131/multipoint-recognition-of-domoic-acid-from-seawater-by-dummy-template-molecularly-imprinted-solid-phase-extraction-coupled-with-high-performance-liquid-chromatography
#17
Xiuping He, Jianlei Chen, Jiangtao Wang, Liju Tan
Due to the high cost of domoic acid (DA), different carboxylic acid compounds including indole-3-acetic acid (IAA), pyrrole-2-formic acid (PFA), pyridine-2,3-dicarboxylic anhydride (PDA), trimesitinic acid (TA) and citric acid (CA) were investigated as dummy templates for the molecularly imprinted solid-phase extraction (MISPE) for selective isolation and pre-concentration of an amnesic shellfish poison (ASP), DA. The highest binding amount of the polymers towards DA was obtained when CA was used as dummy template owing to its high hydrophilicity...
April 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28440059/production-of-itaconic-acid-from-pentose-sugars-by-aspergillus-terreus
#18
Badal C Saha, Gregory J Kennedy, Nasib Qureshi, Michael J Bowman
Itaconic acid (IA), an unsaturated 5-carbon dicarboxylic acid, is a building block platform chemical that is currently produced industrially from glucose by fermentation with Aspergillus terreus. However, lignocellulosic biomass has potential to serve as low cost source of sugars for production of IA. Research needs to be performed to find a suitable A. terreus strain that can use lignocellulose derived pentose sugars and produce IA. One hundred A. terreus strains were evaluated for the first time for production of IA from xylose and arabinose...
April 25, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28427662/ultrasonic-assisted-synthesis-of-a-tetrazine-functionalized-mof-and-its-application-in-colorimetric-detection-of-phenylhydrazine
#19
Sayed Ali Akbar Razavi, Mohammad Yaser Masoomi, Ali Morsali
TMU-34(-2H), [Zn(OBA)(DPT)0.5].DMF, has been sonochemically synthesized by applying H2OBA, (4,4'-oxybis(benzoic acid)), as the dicarboxylate linker, and DPT, (3,6-di(pyridin-4-yl)-1,2,4,5-tetrazine), as pillar spacer. Sonication time, concentration of initial reagents, sonication power and molar ratio of pyridine as modulator has been optimized to synthesize nano powder of TMU-34(-2H) including uniform plate morphology. Nano TMU-34(-2H), can detect phenylhydrazine (PH) by color changing from pink to deep purple...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28425297/new-approaches-for-itaconic-acid-production-bottlenecks-and-possible-remedies
#20
Richa Bafana, R A Pandey
Currently, growing attention is being devoted to the conversion of biomass into value-added products, such as itaconic acid (IA), which is considered as the cleanest alternative to petroleum-based acrylic acid. IA is an unsaturated dicarboxylic acid that is used as a building block chemical for the production of several value-added products such as poly-itaconic acid. IA and its derivatives have a wide range of potential applications in textile, paint, pharmaceutical and chemical industries. Presently, industries are producing IA on the large scale by fermentation from glucose...
April 20, 2017: Critical Reviews in Biotechnology
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