keyword
MENU ▼
Read by QxMD icon Read
search

Crohn's disease,ulcerative colitis,inflammatory bowel disease

keyword
https://www.readbyqxmd.com/read/29330905/evidence-based-consensus-on-opportunistic-infections-in-inflammatory-bowel-disease
#1
Jia Ming Qian
Inflammatory bowel disease (IBD), mainly including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic non-specific intestinal disease. The chronic, protracted course of IBD severely affects the patient's quality of life. The treatment of IBD has gone through three phases.
January 12, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29330783/clinical-pharmacokinetics-and-pharmacodynamics-of-infliximab-in-the-treatment-of-inflammatory-bowel-disease
#2
REVIEW
Amy Hemperly, Niels Vande Casteele
Infliximab was the first monoclonal antibody to be approved for the treatment of pediatric and adult patients with moderately to severely active Crohn's disease (CD) and ulcerative colitis (UC). It has been shown to induce and maintain both clinical remission and mucosal healing in pediatric and adult patients with inflammatory bowel disease (IBD) who are unresponsive or refractory to conventional therapies. The administration of infliximab is weight-based and the drug is administered intravenously. The volume of distribution of infliximab is low and at steady state ranges from 4...
January 12, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29328869/inflammatory-bowel-diseases-and-fermentable-oligosaccharides-disaccharides-monosaccharides-and-polyols-an-overview
#3
Sandra Maria Barbalho, Ricardo de Alvares Goulart, Ana Luíza de Carvalho Aranão, Pamela Grazielle Correa de Oliveira
Inflammatory bowel diseases (IBDs) are mainly represented by ulcerative colitis and Crohn's disease, and the increase in the incidence tends to follow the rapid industrialization and lifestyle of modern societies. FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) consist of molecules that are poorly absorbed in the small intestine and are fermented by bacteria in the colon leading to symptoms such as bloating, flatulence, diarrhea, and abdominal pain. Reduction of the ingestion of FODMAP could reduce the symptoms and improve the quality of life...
January 12, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29325325/-expression-of-microrna-155-in-inflammatory-bowel-disease-and-its-clinical-significance
#4
Y L Ye, Z Pang, W Gu, J J Zheng
Objective: To explore the expression of microRNA-155 in colonic mucosa and peripheral blood in patients with inflammatory bowel disease(IBD), and to examine the clinical value and significance of microRNA-155 in the diagnosis of IBD. Methods: Quatitative reverse-transcription PCR was performed to detect the expression of microRNA-155 in 20 patients with Crohn disease(CD), 21 patients with ulcerative colitis (UC), 18 patients with IBD type unclassified(IBDU), 25 healthy people(control group), 12 patients with infection colitis and 19 patients with ischemia colitis...
December 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29321655/evaluation-of-brain-activity-using-near-infrared-spectroscopy-in-inflammatory-bowel-disease-patients
#5
Tatsuo Fujiwara, Soichi Kono, Kyoko Katakura, Kazumichi Abe, Atsushi Takahashi, Naohiko Gunji, Aki Yokokawa, Kazumasa Kawashima, Rieko Suzuki, Akira Wada, Itaru Miura, Hirooki Yabe, Hiromasa Ohira
Depression is implicated as a risk factor for the recurrence of inflammatory bowel disease (IBD). Near-infrared spectroscopy (NIRS) and brain-derived neurotrophic factor (BDNF) are useful tools for evaluation of brain activity and a depressive state, respectively. The aim of this study was to clarify the association between brain activity or depressive symptoms and IBD using NIRS and BDNF. This study included 36 ulcerative colitis (UC) patients, 32 Crohn's disease (CD) patients, and 17 healthy controls (HC)...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321166/fetal-and-early-life-antibiotics-exposure-and-very-early-onset-inflammatory-bowel-disease-a-population-based-study
#6
Anne K Örtqvist, Cecilia Lundholm, Jonas Halfvarson, Jonas F Ludvigsson, Catarina Almqvist
OBJECTIVE: Earlier studies on antibiotics exposure and development of IBD (Crohn's disease (CD) and ulcerative colitis (UC)) may have been biased by familial factors and gastroenteritis. We aimed to estimate the association between antibiotics during pregnancy or infantile age and very early onset (VEO) IBD. DESIGN: In this cohort study of 827 239 children born in Sweden between 2006 and 2013, we examined the link between exposure to systemic antibiotics and VEO-IBD (diagnosis <6 years of age), using Cox proportional hazard regression models...
January 10, 2018: Gut
https://www.readbyqxmd.com/read/29317842/exercise-in-patients-with-inflammatory-bowel-diseases-current-perspectives
#7
REVIEW
Michael Engels, Raymond K Cross, Millie D Long
Inflammatory bowel diseases (IBDs), including both Crohn's disease (CD) and ulcerative colitis (UC), are chronic autoimmune diseases. Both CD and UC have relapsing and remitting courses. Although effective medical treatments exist for these chronic conditions, some patients do not respond to these traditional therapies. Patients are often left frustrated with incomplete resolution of symptoms and seek alternative or complementary forms of therapy. Patients often search for modifiable factors that could improve their symptoms or help them to maintain periods of remission...
2018: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29317770/corticosteroid-sparing-in-inflammatory-bowel-disease-is-more-often-achieved-in-the-immunomodulator-and-biological-era-results-from-the-dutch-population-based-ibdsl-cohort
#8
Steven F G Jeuring, Vince B C Biemans, Tim R A van den Heuvel, Maurice P Zeegers, Wim H Hameeteman, Mariëlle J L Romberg-Camps, Liekele E Oostenbrug, Ad A M Masclee, Daisy M A E Jonkers, Marieke J Pierik
OBJECTIVES: Corticosteroid-free remission is an emerging treatment goal in the management of inflammatory bowel disease (IBD). In the population-based Inflammatory Bowel Disease South Limburg cohort, we studied temporal changes in corticosteroid use and assessed the corticosteroid-sparing effects of immunomodulators and biologicals in real life. METHODS: In total, 2,823 newly diagnosed patients with Crohn's disease (CD) or ulcerative colitis (UC) were included. Corticosteroid exposure and cumulative days of use were compared between patients diagnosed in 1991-1998 (CD: n=316, UC: n=539), 1999-2005 (CD: n=387, UC: n=527), and 2006-2011 (CD: n=459, UC: n=595)...
January 9, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29317245/current-pharmaceutical-strategies-for-efficient-site-specific-delivery-in-inflamed-distal-intestinal-mucosa
#9
REVIEW
Sumit Sharma, Vivek R Sinha
Inflammatory bowel disorder is associated with certain pathophysiological disturbances which make established techniques of colon targeting more complex and inconsistent. Probable reason is severity of inflammation which leads to more variability in normal range of triggering factors that are being exploited for colon targeting. Influential changes in pathophysiology of intestine during inflammatory bowel disorder including Crohn's disease and ulcerative colitis both in active as well as quiescent stage have been discussed...
January 6, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29317064/comparison-of-geographic-distributions-of-irritable-bowel-syndrome-with-inflammatory-bowel-disease-fail-to-support-common-evolutionary-roots-irritable-bowel-syndrome-and-inflammatory-bowel-diseases-are-not-related-by-evolution
#10
Andrew Szilagyi, Xiaoqing Xue
Irritable Bowel Syndrome (IBS) shares overlapping symptoms and some features of pathogenesis with Inflammatory Bowel Diseases (IBD: Crohn's disease [CD], and Ulcerative Colitis [UC]). Geographic markers such as latitude/sunshine and more recently lactase population distributions are found to be correlated with IBD. As a result of clinical and pathogenic similarities between the 2 conditions, some authorities questioned whether a connection exists between them. We compare IBS directly with IBD, and indirectly with geographic markers associated with IBD, in order to evaluate possible evolutionary links between IBS and IBD...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29315147/nonmelanoma-skin-cancer-risk-in-patients-with-inflammatory-bowel-disease-undergoing-thiopurine-therapy-a-systematic-review-of-the-literature
#11
Joshua W Hagen, Melissa A Pugliano-Mauro
BACKGROUND: Azathioprine and 6-mercaptopurine (thiopurines) are common adjunct treatments for inflammatory bowel disease (IBD). Although thiopurine therapy in organ transplant recipients is known to increase nonmelanoma skin cancers (NMSCs), dermatologic literature yields less data regarding NMSC risk of thiopurine use in IBD. OBJECTIVE: The aim of this study was to systematically review current literature on NMSC risk in patients with IBD using thiopurine therapy...
January 8, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29312611/association-between-sod1-cat-gshpx1-polymorphisms-and-the-risk-of-inflammatory-bowel-disease-in-the-polish-population
#12
Malgorzata Mrowicka, Jerzy Mrowicki, Michal Mik, Radoslaw Wojtczak, Lukasz Dziki, Adam Dziki, Ireneusz Majsterek
Purpose: The main aim of this study was investigate the association between the genetic polymorphism of antioxidant enzyme genes: SOD1, CAT and GSHPX1 and the risk of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis in the Polish population. Methods: A total of 445 subjects including 200 patients with IBD and 245 controls were allowed in this study. We determined activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx1) and examination their association with the SNPs of respective genes (SOD1 +35A/C, CAT C-262T and GSHPX1 Pro197Leu)...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29311644/dynamics-of-metatranscription-in-the-inflammatory-bowel-disease-gut-microbiome
#13
Melanie Schirmer, Eric A Franzosa, Jason Lloyd-Price, Lauren J McIver, Randall Schwager, Tiffany W Poon, Ashwin N Ananthakrishnan, Elizabeth Andrews, Gildardo Barron, Kathleen Lake, Mahadev Prasad, Jenny Sauk, Betsy Stevens, Robin G Wilson, Jonathan Braun, Lee A Denson, Subra Kugathasan, Dermot P B McGovern, Hera Vlamakis, Ramnik J Xavier, Curtis Huttenhower
Inflammatory bowel disease (IBD) is a group of chronic diseases of the digestive tract that affects millions of people worldwide. Genetic, environmental and microbial factors have been implicated in the onset and exacerbation of IBD. However, the mechanisms associating gut microbial dysbioses and aberrant immune responses remain largely unknown. The integrative Human Microbiome Project seeks to close these gaps by examining the dynamics of microbiome functionality in disease by profiling the gut microbiomes of >100 individuals sampled over a 1-year period...
January 8, 2018: Nature Microbiology
https://www.readbyqxmd.com/read/29309905/overall-and-comparative-risk-of-herpes-zoster-with-pharmacotherapy-for-inflammatory-bowel-diseases-a-nationwide-cohort-study
#14
Nabeel Khan, Dhruvan Patel, Chinmay Trivedi, Yash Shah, Gary Lichtenstein, James Lewis, Yu-Xiao Yang
BACKGROUND & AIMS: Patients with inflammatory bowel disease (IBD) might be at increased risk for herpes zoster infection. We sought to quantify the risk of herpes zoster in patients with IBD and evaluate the effects of IBD and IBD medications on the risk of herpes zoster. METHODS: We conducted 2 retrospective studies of populations of Veterans, from January 2000 through June 2016. In study 1, we compared the incidence of herpes zoster among patients with IBD receiving 5-ASA alone vs matched patients without IBD...
January 5, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29309774/glycosylation-of-immunoglobulin-g-associates-with-clinical-features-of-inflammatory-bowel-diseases
#15
Mirna Šimurina, Noortje de Haan, Frano Vučković, Nicholas A Kennedy, Jerko Štambuk, David Falck, Irena Trbojević-Akmačić, Florent Clerc, Genadij Razdorov, Anna Khon, Anna Latiano, Renata D'Incà, Silvio Danese, Stephan Targan, Carol Landers, Marla Dubinsky, Dermot P B McGovern, Vito Annese, Manfred Wuhrer, Gordan Lauc
BACKGROUND AND AIMS: Causes of inflammatory bowel diseases are not well understood and the most prominent forms Crohn's disease (CD) and ulcerative colitis (UC) are sometimes hard to distinguish. Glycosylation of immunoglobulin G (IgG) has been associated with CD and UC. IgG Fc-glycosylation affects IgG effector functions. We evaluated changes in IgG Fc-glycosylation associated with UC and CD, as well as with disease characteristics in different patient groups. METHODS: We analyzed 3441 plasma samples, obtained from 2 independent cohorts of patients with CD (874 patients in Italy and 391 in the United States [US]) or UC (1056 in Italy and 253 in the US and healthy individuals (controls) (427 in Italy and 440 in the US)...
January 5, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29308085/could-mycobacterium-avium-subspecies-paratuberculosis-cause-crohn-s-disease-ulcerative-colitis%C3%A2-and-colorectal-cancer
#16
Ellen S Pierce
Infectious agents are known causes of human cancers. Schistosoma japonicum and Schistosoma mansoni cause a percentage of colorectal cancers in countries where the respective Schistosoma species are prevalent. Colorectal cancer is a complication of ulcerative colitis and colonic Crohn's disease, the two main forms of idiopathic inflammatory bowel disease (IIBD). Mycobacterium avium subspecies paratuberculosis (MAP), the cause of a chronic intestinal disease in domestic and wild ruminants, is one suspected cause of IIBD...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29305860/rvd1-inhibits-tnf%C3%AE-induced-c-myc-expression-in-normal-intestinal-epithelial-cells-and-destabilizes-hyper-expressed-c-myc-in-colon-cancer-cells
#17
Xiancai Zhong, Ha-Na Lee, Young-Joon Surh
Inflammatory bowel diseases, including ulcerative colitis and Crohn's disease, are persistent disorders that lead to development of colitis-associated cancer (CAC). Seeking the resolution of colitis has been addressed as a new therapeutic strategy to CAC. Resolvin D1 (RvD1) is an endogenous lipid mediator that is generated from docosahexaenoic acid during the resolution of inflammation. Although the pro-resolving effects of RvDs have been extensively investigated and well defined, the role for RvD1 in CAC remains largely unknown...
January 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29300856/cutaneous-morbidity-among-inflammatory-bowel-disease-patients-a-cohort-study
#18
Júlia Vide, Filipa Osório, Miguel Costa-Silva, Sofia Lopes, Filomena Azevedo, Cláudia Camila Dias, Sofia Magina, Fernando Magro
Background and aims: Patients afflicted with inflammatory bowel diseases are prone to have cutaneous manifestations. The aim of this study was to investigate their prevalence, type and association to demographic and clinical-related factors. Methods: This was a cross-sectional study. Information relative to patients of a central Portuguese hospital with a definitive diagnosis of an inflammatory bowel disease, who were prospectively recruited, was collected. Results: The final cohort included 342 patients, of whom 62% had Crohn´s disease and 38% had ulcerative colitis...
December 28, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29291447/inflammatory-bowel-disease-patients-experiencing-a-loss-of-response-to-infliximab-regain-long-term-response-after-undergoing-granulocyte-monocyte-apheresis-a-case-series
#19
Yoko Yokoyama, Koji Kamikozuru, Kenji Watanabe, Shiro Nakamura
Up to 50% of patients with ulcerative colitis (UC) or Crohn's disease (CD) experience a loss of response (LOR) to infliximab after an initial response to the drug. Granulocyte/monocyte apheresis (GMA) with the Adacolumn depletes the activated myeloid leukocytes that are known to exacerbate and perpetuate inflammatory bowel diseases, but GMA has hitherto not been applied to patients with LOR to infliximab. We report three cases (2 UC and 1CD) with LOR to maintenance infliximab therapy that received one GMA session/week for 3 consecutive weeks or more...
December 29, 2017: Cytokine
https://www.readbyqxmd.com/read/29290660/efficacy-of-noninvasive-evaluations-in-monitoring-inflammatory-bowel-disease-activity-a-prospective-study-in-china
#20
Jin-Min Chen, Tao Liu, Shan Gao, Xu-Dong Tong, Fei-Hong Deng, Biao Nie
AIM: To optimize the efficacy of noninvasive evaluations in monitoring the endoscopic activity of inflammatory bowel disease (IBD). METHODS: Fecal calprotectin (FC), clinical activity index (CDAI or CAI), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and procalcitonin (PCT) were measured for 136 IBD patients. Also, FC was measured in 25 irritable bowel syndrome (IBS) patients that served as controls. Then, endoscopic activity was determined by other two endoscopists for colonic or ileo-colonic Crohn's disease (CICD) with the "simple endoscopic score for Crohn's disease" (SES-CD), CD-related surgery patients with the Rutgeerts score, and ulcerative colitis (UC) with the Mayo score...
December 14, 2017: World Journal of Gastroenterology: WJG
keyword
keyword
5105
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"