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Crohn's disease,ulcerative colitis,inflammatory bowel disease

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https://www.readbyqxmd.com/read/28088612/alterations-in-cytokine-gene-expression-profile-in-colon-mucosa-of-inflammatory-bowel-disease-patients-on-different-therapeutic-regimens
#1
Tsvetelina Velikova, Dobroslav Kyurkchiev, Zoya Spassova, Iliya Karakolev, Ekaterina Ivanova-Todorova, Iskra Altankova, Spaska Stanilova
Inflammatory bowel disease (IBD) is assumed to be caused by genetic and environmental factors that interact together in promoting intestinal immune dysregulation where cytokines have validated role. However, the underlying intimate mechanisms in the human IBD involving cytokines still needs to be supplemented especially in the clinical context. The aim of this study was to investigate the expression of some inflammatory and regulatory cytokines (IL-17A, IL-23, IL-6, TGFβ1, and IL-10) as well as of the transcription factor FoxP3 in mucosal samples of IBD and non-IBD patients...
January 12, 2017: Cytokine
https://www.readbyqxmd.com/read/28079625/older-age-and-health-related-quality-of-life-in-inflammatory-bowel-diseases
#2
Gabriella Velonias, Grace Conway, Elizabeth Andrews, John J Garber, Hamed Khalili, Vijay Yajnik, Ashwin N Ananthakrishnan
BACKGROUND: The burden of inflammatory bowel disease (IBD) in the older population is increasing. Older-onset disease is associated with reduced use of immunosuppressive medications. In addition, older patients may be more vulnerable to the effect of disease-related symptoms and consequently may experience worse health-related quality of life (HRQoL) compared with younger patients. METHODS: This prospective study included a cohort of patients with Crohn's disease and ulcerative colitis recruited from a single center...
January 6, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28079622/prevalence-and-determinants-of-job-stress-in-patients-with-inflammatory-bowel-disease
#3
Philipp Schreiner, Luc Biedermann, Jean-Benoit Rossel, Gerhard Rogler, Valérie Pittet, Roland von Känel
BACKGROUND: Psychosocial factors have been shown to predict a poor disease course in patients with inflammatory bowel disease (IBD), but whether this applies to job stress is currently unknown. We assessed the prevalence of job stress and its correlates in a large cohort of patients with IBD. METHODS: We included all adult, professionally active patients enrolled between 2006 and 2015 in the Swiss IBD Cohort. Job stress was measured through the self-report effort-reward imbalance ratio and overcommitment (OC) to work questionnaires...
January 10, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28079620/clostridium-difficile-infection-and-risk-of-colectomy-in-patients-with-inflammatory-bowel-disease-a-bias-adjusted-meta-analysis
#4
Yingxi Chen, Luis Furuya-Kanamori, Suhail A Doi, Ashwin N Ananthakrishnan, Martyn Kirk
BACKGROUND: Clostridium difficile infection (CDI) is a common complication of inflammatory bowel diseases (IBDs) and is associated with worse outcome. Variable rates of colectomy have been reported among IBD complicated by CDI. We conducted a systematic review and meta-analysis of studies to assess the association between CDI and colectomy among patients with IBD. METHODS: The literature was systematically searched using PubMed from inception through April 2016...
January 10, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28077249/altered-mucosal-expression-of-micrornas-in-pediatric-patients-with-inflammatory-bowel-disease
#5
Nóra Judit Béres, Zoltán Kiss, Zsófia Sztupinszki, Gábor Lendvai, András Arató, Erna Sziksz, Ádám Vannay, Attila J Szabó, Katalin Eszter Müller, Áron Cseh, Kriszta Boros, Gábor Veres
INTRODUCTION: MicroRNAs (miRs) came recently into focus as promising novel research targets offering new insights into the pathogenesis of inflammatory bowel diseases (IBD). AIMS: The aim of our study was to identify a pediatric IBD (pIBD) characteristic miR profile serving as potential Crohn's disease (CD) and ulcerative colitis (UC) specific diagnostic pattern and to further analyze the related target genes. METHODS: Small RNA sequencing was performed on inflamed and intact colonic biopsies of CD, and control patients...
December 27, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28069913/anti-tnf%C3%AE-antibody-induced-psoriasiform-skin-lesions-in-patients-with-inflammatory-bowel-disease-an-irish-cohort-study
#6
S Kirthi, A-M Tobin, M Hussey, F Scaldaferri, D McNamara
AIM: To determine the prevalence of psoriasis in an IBD cohort with reference to clinical characteristics and anti-TNFα use. METHODS: Patients with psoriasis and IBD were retrospectively identified from the IBD database at Tallaght Hospital from 2000 to 2015. Pertinent clinical data were obtained from patients notes including anti-TNFα exposure. Prevalence rates of genuine and reactive psoriasis were calculated and compared using a students T-test. A p value of < 0...
January 9, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28068895/can-surgery-for-inflammatory-bowel-disease-be-personalized
#7
Antonino Spinelli, Alessandra Marano, Claudio Bacchelli, Nicolò Maria Mariani, Marco Montorsi, Paulo Gustavo Kotze
In the treatment of Inflammatory Bowel Diseases (IBD) despite advances in medical therapies, surgery has maintained a leading role in the management of complications of the disease, as well as in cases of failure of medical therapy. Surgery has become more and more minimally invasive, struggling for a difficult balance between guidelines and personalized treatment tailored on the single patient's need. In the present paper, the authors discuss the possible role for a personalization in debated fields of surgical treatment of Crohn&s disease and ulcerative colitis...
January 5, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28067910/exploring-the-genetic-architecture-of-inflammatory-bowel-disease-by-whole-genome-sequencing-identifies-association-at-adcy7
#8
Yang Luo, Katrina M de Lange, Luke Jostins, Loukas Moutsianas, Joshua Randall, Nicholas A Kennedy, Christopher A Lamb, Shane McCarthy, Tariq Ahmad, Cathryn Edwards, Eva Goncalves Serra, Ailsa Hart, Chris Hawkey, John C Mansfield, Craig Mowat, William G Newman, Sam Nichols, Martin Pollard, Jack Satsangi, Alison Simmons, Mark Tremelling, Holm Uhlig, David C Wilson, James C Lee, Natalie J Prescott, Charlie W Lees, Christopher G Mathew, Miles Parkes, Jeffrey C Barrett, Carl A Anderson
To further resolve the genetic architecture of the inflammatory bowel diseases ulcerative colitis and Crohn's disease, we sequenced the whole genomes of 4,280 patients at low coverage and compared them to 3,652 previously sequenced population controls across 73.5 million variants. We then imputed from these sequences into new and existing genome-wide association study cohorts and tested for association at ∼12 million variants in a total of 16,432 cases and 18,843 controls. We discovered a 0.6% frequency missense variant in ADCY7 that doubles the risk of ulcerative colitis...
January 9, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28063052/monitoring-of-chemically-induced-colitis
#9
Sonja Reißig, Benno Weigmann
Inflammation is a common symptom of inflammatory bowel disease (IBD). Actually, many experimental models of colitis exist and try to mimic the human situation in order to understand the pathogenesis of Crohn's disease and ulcerative colitis. These experimental models of inflammation can be characterized by specific parameters, which illustrate the proceeding inflammatory process. By use of these models potentially new reagents for improved therapeutic approaches can be analyzed. Here, we describe the TNBS-mediated colitis model and specify different parameters for the detailed characterization of the inflammatory process in experimental colitis models...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28059861/effect-of-threatening-life-experiences-and-adverse-family-relations-in-ulcerative-colitis-analysis-using-structural-equation-modeling-and-comparison-with-crohn-s-disease
#10
Vered Slonim-Nevo, Orly Sarid, Michael Friger, Doron Schwartz, Ruslan Sergienko, Avihu Pereg, Hillel Vardi, Terri Singer, Elena Chernin, Dan Greenberg, Shmuel Odes
BACKGROUND AND AIMS: We published that threatening life experiences and adverse family relations impact Crohn's disease (CD) adversely. In this study, we examine the influence of these stressors in ulcerative colitis (UC). PATIENTS AND METHODS: Patients completed demography, economic status (ES), the Patient-Simple Clinical Colitis Activity Index (P-SCCAI), the Short Inflammatory Bowel Disease Questionnaire (SIBDQ), the Short-Form Health Survey (SF-36), the Brief Symptom Inventory (BSI), the Family Assessment Device (FAD), and the List of Threatening Life Experiences (LTE)...
January 4, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28057654/protocol-for-a-prospective-controlled-observational-study-to-evaluate-the-influence-of-hypoxia-on-healthy-volunteers-and-patients-with-inflammatory-bowel-disease-the-altitude-ibd-study
#11
Stephan Vavricka, Pedro A Ruiz, Sylvie Scharl, Luc Biedermann, Michael Scharl, Cheryl de Vallière, Carsten Lundby, Roland H Wenger, Leonhard Held, Tobias M Merz, Max Gassmann, Thomas Lutz, Andres Kunz, Denis Bron, Adriano Fontana, Laura Strauss, Achim Weber, Michael Fried, Gerhard Rogler, Jonas Zeitz
INTRODUCTION: Inflammatory bowel disease (IBD) is a chronic intestinal disorder, often leading to an impaired quality of life in affected patients. The importance of environmental factors in the pathogenesis of IBD, including their disease-modifying potential, is increasingly recognised. Hypoxia seems to be an important driver of inflammation, as has been reported by our group and others. The aim of the study is to evaluate if hypoxia can alter disease activity of IBD measured by Harvey-Bradshaw Activity Index in Crohn's disease (increase to ≥5 points) and the partial Mayo Score for ulcerative colitis (increase to ≥2 points)...
January 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28053669/mycobacterium-avium-subsp-paratuberculosis-and-associated-risk-factors-for-inflammatory-bowel-disease-in-iranian-patients
#12
Samin Zamani, Mohammad Reza Zali, Hamid Asadzadeh Aghdaei, Leonardo Antonio Sechi, Magdalena Niegowska, Elisa Caggiu, Rouhollah Keshavarz, Nader Mosavari, Mohammad Mehdi Feizabadi
BACKGROUND: Inflammatory bowel disease (IBD) is described as a relapsing condition with high morbidity and uncertain complex pathogenesis. The association of Mycobacterium avium ssp. paratuberculosis (MAP) with Crohn's disease (CD) in human has been debated for decades, however there is no confirmed data to verify such relations in Iran. The aim of this study was to investigate risk factors and a possible role of MAP in Iranian patients with CD. METHODS: Anti-MAP antibodies were detected in serum of IBD patients and subjects without IBD (nIBD) through ELISA; MAP DNA and viable MAP cells were identified in patients' biopsies through nested PCR and direct culture methods, respectively...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28052094/association-between-polymorphisms-in-antioxidant-genes-and-inflammatory-bowel-disease
#13
Cristiana Costa Pereira, Cecília Durães, Rosa Coelho, Daniela Grácio, Marco Silva, Armando Peixoto, Paula Lago, Márcia Pereira, Telmo Catarino, Salomé Pinho, João Paulo Teixeira, Guilherme Macedo, Vito Annese, Fernando Magro
Inflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Crohn's disease (CD) and ulcerative colitis (UC). Single nucleotide polymorphisms (SNPs) in the antioxidant genes SOD2 (rs4880) and GPX1 (rs1050450) were genotyped in a Portuguese population comprising 436 Crohn's disease and 367 ulcerative colitis patients, and 434 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28050782/colorectal-cancer-in-inflammatory-bowel-diseases-a-population-based-study-in-utah
#14
N Jewel Samadder, John F Valentine, Stephen Guthery, Harminder Singh, Charles N Bernstein, Yuan Wan, Jathine Wong, Kenneth Boucher, Lisa Pappas, Kerry Rowe, Mary Bronner, Cornelia M Ulrich, Randall W Burt, Karen Curtin, Ken R Smith
BACKGROUND AND AIMS: The molecular, endoscopic, and histological features of IBD-associated CRC differ from sporadic CRC. The objective of this study was to describe the prevalence, clinical features, and prognosis of IBD-associated CRC compared to patients with sporadic CRC in a US statewide population-based cohort. METHODS: All newly diagnosed cases of CRC between 1996 and 2011 were obtained from Utah Cancer Registry. IBD was identified using a previously validated algorithm, from statewide databases of Intermountain Healthcare, University of Utah Health Sciences, and the Utah Population Database...
January 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28045777/capillary-flow-rates-in-the-duodenum-of-pediatric-ulcerative-colitis-patients-are-increased-and-unrelated-to-inflammation
#15
Deenaz Zaidi, Lucas Churchill, Hien Q Huynh, Matthew W Carroll, Rabin Persad, Eytan Wine
BACKGROUND: Inflammatory bowel diseases (IBD), including Crohn disease (CD) and ulcerative colitis (UC), are chronic pediatric disorders. Changes in vasculature are described in IBD but these could be secondary to inflammation and the role in pathogenesis is poorly understood. Assessing circulatory changes in typically unaffected sites in IBD (e.g., duodenum), when inflammation is absent, can identify vascular changes associated with pathogenesis. AIM: To measure capillary flow rates in duodenal mucosa using probe-based confocal laser endomicroscopy (pCLE) during endoscopy in children with IBD...
December 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28045769/diverting-ileostomy-for-the-treatment-of-severe-refractory-pediatric-inflammatory-bowel-disease
#16
Elizabeth C Maxwell, Noor Dawany, Robert N Baldassano, Petar Mamula, Peter Mattei, Lindsey Albenberg, Judith R Kelsen
OBJECTIVES: Diverting ileostomy is used as a temporizing therapy in patients with perianal Crohn disease; however, little data exist regarding its use for colonic disease. The primary aim of the present study was to determine the role of diversion in severe refractory colonic inflammatory bowel disease (IBD) in a pediatric population. METHODS: Retrospective study of patients who underwent diverting ileostomy at The Children's Hospital of Philadelphia from 2000 to 2014 for the management of severe, refractory colonic IBD...
December 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28042386/endoscopic-evaluation-in-diagnosis-and-management-of-inflammatory-bowel-disease
#17
REVIEW
Carthage P Moran, Barra Neary, Glen A Doherty
Endoscopy is a keystone in the management of patients with inflammatory bowel disease (IBD). It is the fundamental diagnostic tool for IBD, and can help discern between ulcerative colitis and Crohn's disease. Endoscopic assessment provides an objective end point in clinical trials, and identifies patients in clinical practice who may benefit from treatment escalation and may assist risk stratification in patients seeking to discontinue therapy. Recent advances in endoscopic assessment of patients with IBD include video capsule endoscopy, and chromoendoscopy...
December 16, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28042244/satisfaction-and-expectations-of-patients-with-inflammatory-bowel-disease-on-biologic-therapy-a-multicenter-study
#18
Alessandra Guarini, Silvia Biagini, Antonella Capaldi, Daniela Carretto, Anna De Angelis, Salvatore Iudice, Giuseppina Martino, Barbara Marziali, Roberta Mattiola, Cristina Ongarelli, Francesca Maria Onidi, Manuela Prinzio, Reetha Puthiavettil, Romina Sardi, Elisa Schiavoni, Rita Sinatora, Angelo Zullo
BACKGROUND: The satisfaction perceived by patients with chronic diseases affects clinical outcomes and healthcare costs. Some patients with inflammatory bowel disease (IBD) develop a more severe form requiring biologic therapy. We assessed the quality of care perceived by IBD patients in dedicated centers. METHODS: This prospective, cross-sectional, multicenter study enrolled consecutive IBD patients who underwent biologic therapy in the participating centers. The nurses directly involved in the management of these patients explained the rationale of the survey, provided a specific questionnaire (CACHE), and collected data...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28040992/tweak-is-not-elevated-in-patients-with-newly-diagnosed-inflammatory-bowel-disease
#19
Tore Grimstad, Inger Marie Skoie, Jessica Doerner, Kjetil Isaksen, Lars Karlsen, Lars Aabakken, Roald Omdal, Chaim Putterman
OBJECTIVE: Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) may be involved in the pathogenesis of inflammatory bowel disease. The aim was to investigate if TWEAK may reflect disease activity in inflammatory bowel disease. MATERIALS AND METHODS: In this cohort study, 139 consecutive patients with newly diagnosed and previously untreated inflammatory bowel disease - 95 with ulcerative colitis (UC) and 44 with Crohn's disease (CD) - underwent colonoscopy...
December 31, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28039805/dextran-sulphate-sodium-colitis-in-c57bl-6j-mice-is-alleviated-by-lactococcus-lactis-and-worsened-by-the-neutralization-of-tumor-necrosis-factor-%C3%AE
#20
Aleš Berlec, Martina Perše, Matjaž Ravnikar, Mojca Lunder, Andreja Erman, Anton Cerar, Borut Štrukelj
TNFα has a well-established role in inflammatory bowel disease that affects the gastrointestinal tract and is usually manifested as Crohn's disease or ulcerative colitis. We have compared Lactococcus lactis NZ9000 displaying TNFα-binding affibody with control Lactococcus lactis and with anti-TNFα antibody infliximab for the treatment of mice with dextran sulphate sodium (DSS)-induced colitis. L. lactis NZ9000 alleviated the colitis severity one week after colitis induction with DSS, more effectively when administered in preventive fashion prior to, during and after DSS administration...
February 2017: International Immunopharmacology
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