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Cervical manipulation

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https://www.readbyqxmd.com/read/28415759/kshv-co-infection-down-regulates-hpv16-e6-and-e7-from-cervical-cancer-cells
#1
Lu Dai, Yueyu Cao, Wei Jiang, Jovanny Zabaleta, Zhongmin Liu, Jing Qiao, Zhiqiang Qin
High-risk human papillomavirus (HPV) infection is the etiological agent of some malignancies such as cervical, oral and oropharyngeal cancers. Kaposi sarcoma-associated herpesvirus (KSHV) represents a principal causative agent of several human cancers arising in those immunocompromised patients. Interestingly, KSHV DNA has been detected in the oral cavity and the female genital tract, although its detection rate in cervical samples is very low and few reports are about KSHV/HPV co-infection. Therefore, it remains unclear about the role of KSHV co-infection in the development of HPV-related neoplasias...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28357377/chlamydia-trachomatis-genital-infections
#2
REVIEW
Catherine M O'Connell, Morgan E Ferone
Etiology, transmission and protection: Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infection (STI) globally. However, C. trachomatis also causes trachoma in endemic areas, mostly Africa and the Middle East, and is a leading cause of preventable blindness worldwide. Epidemiology, incidence and prevalence: The World Health Organization estimates 131 million new cases of C. trachomatis genital infection occur annually. Globally, infection is most prevalent in young women and men (14-25 years), likely driven by asymptomatic infection, inadequate partner treatment and delayed development of protective immunity...
September 5, 2016: Microbial Cell
https://www.readbyqxmd.com/read/28338752/strategies-for-evaluating-the-assumptions-of-the-regression-discontinuity-design-a-case-study-using-a-human-papillomavirus-vaccination-programme
#3
Leah M Smith, Linda E Lévesque, Jay S Kaufman, Erin C Strumpf
Background: The regression discontinuity design (RDD) is a quasi-experimental approach used to avoid confounding bias in the assessment of new policies and interventions. It is applied specifically in situations where individuals are assigned to a policy/intervention based on whether they are above or below a pre-specified cut-off on a continuously measured variable, such as birth date, income or weight. The strength of the design is that, provided individuals do not manipulate the value of this variable, assignment to the policy/intervention is considered as good as random for individuals close to the cut-off...
October 8, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28336131/modulating-the-dna-damage-response-to-improve-treatment-response-in-cervical-cancer
#4
L H Cossar, A G Schache, J M Risk, J J Sacco, N J Jones, R Lord
Cervical cancer is the fourth most common cause of cancer-related death in women worldwide and new therapeutic approaches are needed to improve clinical outcomes for this group of patients. Current treatment protocols for locally advanced and metastatic disease consist of ionising radiation and chemotherapy. Chemoradiation induces cytotoxic levels of DNA double-strand breaks, which activates programmed cell death via the DNA damage response (DDR). Cervical cancers are unique given an almost exclusive association with human papillomavirus (HPV) infection; a potent manipulator of the DDR, with the potential to alter tumour sensitivity to DNA-damaging agents and influence treatment response...
March 20, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28324213/-split-and-splayed-c3-traumatic-lateral-c2-3-dislocation-without-neurological-deficits-unique-case-and-its-management
#5
Apinderpreeet Singh, Pravin Salunke, Rajeev P Kamble
BACKGROUND: Traumatic C2-3 dislocation has been often described in the antero-posterior plane but is extremely rare in the lateral plane. Such dislocations have been described in thoraco-lumbar and C1-2. The need to study the imaging in multiple planes has been highlighted to plan proper realignment. METHODS: A young male presented with neck pain alone following a train accident. The imaging showed a fracture of C3 splaying it. The C2-3 showed lateral dislocation in the lateral plane with locked C2-3 facets on one side and C3-4 facets on the other...
March 21, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28303160/cervical-rotatory-manipulation-decreases-uniaxial-tensile-properties-of-rabbit-atherosclerotic-internal-carotid-artery
#6
Shaoqun Zhang, Ji Qi, Lei Zhang, Chao Chen, Shubhro Mondal, Kaike Ping, Yili Chen, Yikai Li
Objective. To investigate the effects of one of the Chinese massage therapies, cervical rotatory manipulation (CRM), on uniaxial tensile properties of rabbit atherosclerotic internal carotid artery (ICA). Methods. 40 male purebred New Zealand white rabbits were randomly divided into CRM-Model group, Non-CRM-Model group, CRM-Normal group, and Non-CRM-Normal group. After modeling (atherosclerotic model) and intervention (CRM or Non-CRM), uniaxial tensile tests were performed on the ICAs to assess the differences in tensile mechanical properties between the four groups...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28274487/manipulation-peak-forces-across-spinal-regions-for-children-using-mannequin-simulators
#7
John J Triano, Steven Lester, David Starmer, Elise G Hewitt
OBJECTIVE: The purpose of this work was to create an exploratory database of manipulation treatment force variability as a function of the intent of an experienced clinician sub-specializing in the care of children to match treatment to childhood category. Data of this type are necessary for realistic planning of dose-response and safety studies on therapeutic benefit. METHODS: The project evaluated the transmitted peak forces of procedures applied to mannequins of different stature for younger and older children...
March 5, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28265158/effects-of-manipulation-of-the-thorax-and-intensity-of-the-pressure-biofeedback-unit-on-the-superficial-cervical-flexors-muscle-during-craniocervical-flexion-exercise
#8
Jin Mo Yang, Hyun-Gyu Cha, Myoung-Kwon Kim
[Purpose] This study examined the effects of manipulation of the thorax and the intensity of the pressure biofeedback unit on the superficial cervical flexors muscle during craniocervical flexion exercise. [Subjects and Methods] Thirty three subjects participated in the experiment. Thirty three healthy people without any orthopedic history were also selected. The subjects could monitor the pressure applied to cervical vertebra 3 of the craniocervical junction by markings on the pressure biofeedback unit. Craniocervical flexion exercise was performed for 20 seconds per pressure, and two minutes of rest was allowed after exercise to reduce muscle fatigue...
February 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28261334/twist1-enhances-hypoxia-induced-radioresistance-in-cervical-cancer-cells-by-promoting-nuclear-egfr-localization
#9
Hua Xiong, Xin Nie, Yanmei Zou, Chen Gong, Yang Li, Hua Wu, Hong Qiu, Lin Yang, Liang Zhuang, Peng Zhang, Jing Zhang, Yihua Wang, Huihua Xiong
Twist1 is a crucial transcription factor that regulates epithelial mesenchymal transition and involves in metastasis. Recent evidence suggests that Twist1 plays important role in hypoxia-induced radioresistance, but the underlying mechanism remains elusive. Here we investigated the change of Twist1 expression in human cervical squamous cancer cell line SiHa after hypoxia treatment. We also explored the role of Twist1 in radioresistance by manipulating the expression level of Twist1. We observed that hypoxia treatment elevated the expression of Twist1 in SiHa cells...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28254504/robotic-assisted-laparoscopic-trachelectomy-a-standard-technique
#10
Mohamad S Mahmoud
STUDY OBJECTIVE: To describe a standard reproducible technique for simple robotic- assisted laparoscopic trachelectomy. DESIGN: Step-by-step demonstration of the technique using videos and pictures (Canadian Task Force classification level 3). SETTING: The incidence of trachelectomy after supracervical hysterectomy has been increasing, given the popularity of supracervical hysterectomy. The most common indication for trachelectomy is symptomatic cyclic bleeding...
February 27, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28253371/autophagy-regulates-ubc9-levels-during-viral-mediated-tumorigenesis
#11
Domenico Mattoscio, Chiara Casadio, Claudia Miccolo, Fausto Maffini, Andrea Raimondi, Carlo Tacchetti, Tarik Gheit, Marta Tagliabue, Viviana E Galimberti, Francesca De Lorenzi, Michael Pawlita, Fausto Chiesa, Mohssen Ansarin, Massimo Tommasino, Susanna Chiocca
UBC9, the sole E2-conjugating enzyme required for SUMOylation, is a key regulator of essential cellular functions and, as such, is frequently altered in cancers. Along these lines, we recently reported that its expression gradually increases during early stages of human papillomavirus (HPV)-mediated cervical lesions transformation. However, a better understanding of how UBC9 is exploited by transforming viral oncoproteins is still needed. In the present study, we show that in human samples HPV drives UBC9 up-regulation also in very early steps of head and neck tumorigenesis, pointing to the important role for UBC9 in the HPV-mediated carcinogenic program...
March 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28239594/subluxation-of-the-cricoarytenoid-joint-after-external-laryngeal-trauma-a-rare-case-and-review-of-the-literature
#12
Eviatar Friedlander, Paula Martínez Pascual, Julia Da Costa Belisario, Daniel Poletti Serafini
Cricoarytenoid joint subluxation is rare condition. There are <200 cases reported in the English literature. The most frequent cause of this condition is a traumatic tracheal intubation which account for approximately 80 % of all cases. The most common symptoms are dysphonia and pain of the anterior region of the neck which appear after upper airway manipulation or cervical trauma. In this report we present a well-documented case of a 31 year old male that was referred to the outpatient clinic because of acute dysphonia and pain that appeared immediately after receiving a blow of a soccer ball...
March 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28215058/effect-of-cervical-versus-thoracic-spinal-manipulation-on-peripheral-neural-features-and-grip-strength-in-subjects-with-chronic-mechanical-neck-pain-a-randomized-controlled-trial
#13
Francisco Bautista-Aguirre, Ángel Oliva-Pascual-Vaca, Alberto M Heredia-Rizo, Juan J Boscá-Gandía, François Ricard, Cleofás Rodriguez-Blanco
BACKGROUND: Cervical and thoracic spinal manipulative therapy has shown positive impact for relief of pain and improve function in non-specific mechanical neck pain. Several attempts have been made to compare their effectiveness although previous studies lacked a control group, assessed acute neck pain or combined thrust and nonthrust techniques. AIM: To compare the immediate effects of cervical and thoracic spinal thrust manipulations on mechanosensitivity of upper limb nerve trunks and grip strength in patients with chronic non-specific mechanical neck pain...
February 17, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28194135/inaccurate-saccades-and-enhanced-vestibulo-ocular-reflex-suppression-during-combined-eye-head-movements-in-patients-with-chronic-neck-pain-possible-implications-for-cervical-vertigo
#14
Janine L Johnston, Pierre M Daye, Glen T D Thomson
BACKGROUND: The primate ocular motor system is designed to acquire peripheral targets of interest by coordinating visual, vestibular, and neck muscle activation signals. The vestibulo-ocular reflex (VOR) is greatly reduced at the onset of large eye-head (gaze) saccades and resumes before the end of the saccades to stabilize eye-in-orbit and ensure accurate target acquisition. Previous studies have relied on manipulating head movements in normal individuals to study VOR suppression and gaze kinematics...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28186477/bilateral-sagittal-split-mandibular-osteotomies-for-enhanced-exposure-of-the-anterior-cervical-spine-in-children-technical-note
#15
Michael Karsy, Neal Moores, Faizi Siddiqi, Douglas L Brockmeyer, Robert J Bollo
The bilateral sagittal split mandibular osteotomy (BSSMO), a common maxillofacial technique for expanding the oropharynx during treatment of micrognathia, is a rarely employed but useful adjunct to improve surgical access to the ventral cervical spine in children. Specifically, it provides enhanced exposure of the craniocervical junction in the context of midface hypoplasia, and of the subaxial cervical spine in children with severe kyphosis. The authors describe their technique for BSSMO and evaluate long-term outcomes in patients...
April 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28174410/-benign-metastasizing-leiomyoma-of-the-lung-report-of-a-case
#16
Takahiro Sawada, Satoshi Yamamoto, Hajime Sugihara, Akinori Iwasaki
A 71-year-old woman, in whom computed tomography revealed a solitary mass shadow at the base of the left lung, underwent resection of the mass. Histopathological examination showed estrogen receptor-positive leiomyoma cells growing in cords and mixed with glandular structures composed of alveolar cells. These findings led to a diagnosis of benign metastatic leiomyoma. Benign metastatic leiomyoma is a rare disease in which histologically benign uterine leiomyoma cells metastasize to different sites of the body...
February 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28171776/adverse-events-associated-with-the-use-of-cervical-spine-manipulation-or-mobilization-and-patient-characteristics-a-systematic-review
#17
REVIEW
H A Kranenburg, M A Schmitt, E J Puentedura, G J Luijckx, C P van der Schans
Cervical spinal manipulation (CSM) and cervical mobilization are frequently used in patients with neck pain and headache. Pre-manipulative cervical instability and arterial integrity tests appear to be unreliable in identifying patients at risk for adverse events. It would be valuable if patients at risk could be identified by specific characteristics during the preliminary screening. Objective was to identify characteristics of 1) patients, 2) practitioners, 3) treatment process and 4) adverse events (AE) occurring after CSM or cervical mobilization...
April 2017: Musculoskelet Sci Pract
https://www.readbyqxmd.com/read/28167971/glucose-metabolic-changes-in-the-brain-and-muscles-of-patients-with-nonspecific-neck-pain-treated-by-spinal-manipulation-therapy-a-18-f-fdg-pet-study
#18
Akie Inami, Takeshi Ogura, Shoichi Watanuki, Md Mehedi Masud, Katsuhiko Shibuya, Masayasu Miyake, Rin Matsuda, Kotaro Hiraoka, Masatoshi Itoh, Arlan W Fuhr, Kazuhiko Yanai, Manabu Tashiro
Objective. The aim of this study was to investigate changes in brain and muscle glucose metabolism that are not yet known, using positron emission tomography with [(18)F]fluorodeoxyglucose ([(18)F]FDG PET). Methods. Twenty-one male volunteers were recruited for the present study. [(18)F]FDG PET scanning was performed twice on each subject: once after the spinal manipulation therapy (SMT) intervention (treatment condition) and once after resting (control condition). We performed the SMT intervention using an adjustment device...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28161015/-electrophysiological-testing-in-spinal-cord-tumors
#19
REVIEW
N André-Obadia, F Mauguière
Evoked potentials (EPs) are useful to evaluate the functional impairment of motor and somatosensory pathways in spinal cord tumors. Conduction through pyramidal tracts is evaluated by motor EPs (MEPs) elicited by transcranial stimulation, magnetic for awake patients or electric in the operating room. Somatosensory EPs (SEPs) and laser EPs (LEPs) are complementary procedures to explore conduction in dorsal columns and spinothalamic tracts, respectively. MEPs as well as SEPs show conduction abnormalities in about 60% of cases with a sensitivity that increases up to 70% when both procedures are carried out...
February 1, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28070268/a-systematic-review-of-thrust-manipulation-for-non-surgical-shoulder-conditions
#20
REVIEW
Amy L Minkalis, Robert D Vining, Cynthia R Long, Cheryl Hawk, Katie de Luca
PURPOSE: Although many conservative management options are available for patients with non-surgical shoulder conditions, there is little evidence of their effectiveness. This review investigated one manual therapy approach, thrust manipulation, as a treatment option. METHODS: A systematic search was conducted of the electronic databases from inception to March 2016: PubMed, PEDro, ICL, CINAHL, and AMED. Two independent reviewers conducted the screening process to determine article eligibility...
2017: Chiropractic & Manual Therapies
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