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sudden sensorineural hearing loss

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https://www.readbyqxmd.com/read/28744995/idiopathic-sudden-sensorineural-hearing-loss-and-m%C3%A3-ni%C3%A3-re-syndrome-the-role-of-cerebral-venous-drainage
#1
Marco Matteo Ciccone, Pietro Scicchitano, Michele Gesualdo, Francesca Cortese, Annapaola Zito, Fabio Manca, Barbara Boninfante, Pasquale Recchia, Domenico Leogrande, Domenico Viola, Marialessia Damiani, Valeria Gambacorta, Antonio Piccolo, Vincenzo De Ceglie, Nicola Quaranta
AIM: to evaluate the influence of cerebral venous drainage on the pathogenesis of idiopathic sudden sensorineural hearing loss (ISSHL) and Ménière syndrome (MD). METHODS: we enrolled 59 consecutive patients (32 males, mean age 53.05+15.37 years): 40 ISSHL and 19 MD. All underwent physical examination, biochemical evaluation (glycemic and lipid profile, viral serology, C reactive protein, etc), audiometric (tonal, vocal, vestibular evoked myogenic potentials and auditory brainstem response test) and impedentiometric examination...
July 26, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28738977/glutathione-peroxidase-3-gene-polymorphisms-and-the-risk-of-sudden-sensorineural-hearing-loss
#2
Chen-Yu Chien, Tzu-Yen Huang, Shu-Yu Tai, Ning-Chia Chang, Hsun-Mo Wang, Ling-Feng Wang, Kuen-Yao Ho
The glutathione peroxidase 3 gene (GPX3) is reported to be a risk factor for arterial ischaemic stroke and cerebral venous thrombosis. GPX3 may be one of the aetiologies of sudden sensorineural hearing loss (SSNHL), which might be attributed to the genetic effect of GPX3 by influence reactive oxygen species (ROS). Unbalanced ROS have been associated with susceptibility to SSNHL. Therefore, we conducted a case-control study with 416 SSNHL cases and 255 controls. Five single nucleotide polymorphisms (SNPs) were selected...
July 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28708796/significance-of-endolymphatic-hydrops-in-ears-with-unilateral-sensorineural-hearing-loss
#3
Yuriko Okazaki, Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Ken Kato, Shinji Naganawa, Michihiko Sone
OBJECTIVE: The purpose of this study was to investigate the existence of endolymphatic hydrops (EH) in affected and unaffected ears in patients with unilateral sensorineural hearing loss (SNHL) using contrast-enhanced magnetic resonance imaging (MRI), and to evaluate the significance of EH in various otological diseases. STUDY DESIGN: Retrospective study. SETTING: University hospital. METHODS: One hundred eighty-two ears from 91 patients with unilateral SNHL were studied...
July 13, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28680488/sudden-sensorioneural-hearing-loss-and-autoimmune-systemic-diseases
#4
Bruno Almeida Antunes Rossini, Norma de Oliveira Penido, Mario Sergio Lei Munhoz, Eduardo Amaro Bogaz, Renata Souza Curi
Introduction  Several authors have demonstrated the relationship between sudden sensorineural hearing loss (SNHL) and systemic autoimmune diseases (SAD). Immune-mediated SNHL can rarely present as unilateral sudden SNHL and manifests itself in the contralateral ear only after years. It presents clinical relevance for being one of the few SNHL that may be reversible given that early and appropriate treatment is applied. Objective  The objective of this study is to describe the clinical presentations and audiological findings from patients with idiopathic sudden SNHL and SAD associated with a probable diagnosis of immune-mediated SNHL...
July 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28678056/enlarged-vestibular-aqueduct-syndrome-sudden-hearing-loss-in-a-child-with-a-cerebral-shunt
#5
Wendi-Jo Wendt, Andrew Hashikawa
Enlarged vestibular aqueduct syndrome (EVAS) is the most common congenital ear anomaly that causes sensorineural hearing loss in children and may predispose a child to sudden hearing loss from sudden pressure changes or minor head trauma. We report a case of a 4-year-old boy with a history of a ventriculoperitoneal shunt and migraines who presented to the emergency department with parental and child care provider reports of acute hearing loss, without a history of trauma, infection, or hardware malfunction, who was diagnosed with bilateral EVAS...
July 4, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28662721/rheopheresis-in-treatment-of-idiopathic-sensorineural-sudden-hearing-loss
#6
Milan Kostal, Jakub Drsata, Milan Bláha, Miriam Lánská, Viktor Chrobok
BACKROUND: Only few therapeutic options exist for patients with refractory sudden idiopathic sensorineural hearing loss (SISHL). Little is known about the efficacy of second-line therapies. Rheopheresis seems to be an effective therapeutic possibility. METHODS: Between 2012 and 2015, 106 patients with SISHL were enrolled in the study, of whom 52 were refractory to initial treatment. As salvage therapy, these patients were offered either 3 sessions of rheopheresis (33 pts) or intratympanic steroid treatment through MicroWick application (19 pts)...
June 29, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28648633/identification-of-evidence-for-autoimmune-pathology-of-bilateral-sudden-sensorineural-hearing-loss-using-proteomic-analysis
#7
Jeon Mi Lee, Jin Young Kim, Jinwoong Bok, Kyu-Sung Kim, Jae Young Choi, Sung Huhn Kim
Sudden sensorineural hearing loss (S-SNHL) is an inner ear disorder with an abrupt hearing loss occurring <3days. The pathologic mechanism of the disease remains unclear, although autoimmunity has been regarded as one of the suggested causes, especially in bilateral form. In this study, we aimed to provide evidence for the involvement of autoimmunity in bilateral S-SNHL using proteomic approaches such as ProtoArray®, western blotting, immunoprecipitation, and liquid column mass spectrometry for mass screening of candidate antigens and autoantibodies based on the hypothesis that multiple autoantibodies and target antigens must exist in order for autoimmune bilateral S-SNHL to develop...
June 23, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28639554/evaluation-of-procalcitonin-and-hs-crp-levels-in-sudden-sensorineural-hearing-loss
#8
Sercan Göde, Göksel Turhal, İsa Kaya, Halil İbrahim Mavili, Tayfun Kirazlı
OBJECTIVE: The aim of this study was to evaluate procalcitonin and high sensitive c-reactive protein (hs-CRP) levels in idiopathic sudden sensorineural hearing loss (ISSNHL) patients and assess their correlations with the clinical prognosis. MATERIALS AND METHODS: Twenty-three ISSNHL patients were included in the study (group A). The control group was consisted of 19 patients (group B). Procalcitonin and hs-CRP levels were compared between the groups. The relationship between procalcitonin and hs-CRP levels and the configuration of the audiogram, degree of hearing loss [partial or total (>90 dB)], and status of improvement (improvement of > 15 dB in the first month PTA) were evaluated...
June 21, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28616773/intracochlear-schwannoma-tumor-removal-via-subtotal-cochleoectomy-and-partial-cochlear-reconstruction-with-preservation-of%C3%A2-semicircular-canal-function
#9
S K Plontke, S Kösling, N Pazaitis, T Rahne
We report about a patient, who in 2005, as a 37-year-old, experienced a sudden, mild to moderate, mid-frequency sensorineural hearing loss in the right ear, along with tinnitus and mild dizziness. MRI of the temporal bone revealed a very small (1 mm) enhancing lesion in the second turn of the right cochlea after injection of contrast medium. Hearing gradually deteriorated, with complete hearing loss in 2015. At this time, an MRI scan showed a lesion completely filling the cochlea.The tumor was removed through a subtotal cochleoectomy...
June 14, 2017: HNO
https://www.readbyqxmd.com/read/28616232/treatment-of-sudden-hearing-loss-using-electro-acupuncture
#10
Ya-Ching Chang, Kwok-Ying Chan
OBJECTIVES: Sudden neurosensory deafness is the second debilitating disease in China. In fact, the current treatment is limited to hearing aids, assistive devices and cochlear implants. However, some patients might not be suitable for surgery or even hearing aids. METHODS: Hereby, we report a pediatric case of sudden sensorineural hearing loss accompanied by otalgia and blocked ear sensation. RESULTS: He firstly failed with conventional treatment but later his hearing symptoms were improved with our electro-acupuncture therapy according to pure tone audiometry findings and clinical responses...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28578424/aminophylline-restores-glucocorticoid-sensitivity-in-a-guinea-pig-model-of-sudden-sensorineural-hearing-loss-induced-by-lipopolysaccharide
#11
Qiong-Qiong Zhou, Yan-Hong Dai, Xiao-Ping Du, Jie Hou, Hui Qi, Wan-Dong She
Glucocorticoids have been used to treat hearing loss and vestibular dysfunction for many years. However, some reports have indicated that a subset of patients with these disorders exhibit glucocorticoid insensitivity or resistance. A reduction in histone deacetylase 2 (HDAC2) activity and expression has been reported to play a critical role in glucocorticoid resistance. Here, we investigated the protective effects of aminophylline on HDAC2 expression and glucocorticoid sensitivity in lipopolysaccharide (LPS)-induced sudden sensorineural hearing loss in guinea pigs...
June 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28555597/hyperbaric-oxygen-therapy-as-salvage-therapy-for-sudden-sensorineural-hearing-loss
#12
Jakov Ajduk, Mihael Ries, Robert Trotic, Ivana Marinac, Kovacic Vlatka, Vladimir Bedekovic
OBJECTIVE: To measure the effect of hyperbaric oxygen (HBO) therapy as salvage therapy after the failure of steroid therapy for sudden sensorineural hearing loss (SSNHL). MATERIALS AND METHODS: Ninety-three patients with SSNHL were unsuccessfully treated with systemic steroid therapy. Following steroid therapy, 43 patients received additional HBO therapy while 50 did not. Hearing levels at 0.25, 0.5, 1, 2, 4, and 8 kHz before and after therapy were measured. RESULTS: A significant difference in hearing thresholds after HBO therapy was found at all frequencies in patients with a hearing loss of >61 dB...
April 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28546251/mr-imaging-in-sudden-sensorineural-hearing-loss-time-to-talk
#13
G Conte, F Di Berardino, C Sina, D Zanetti, E Scola, C Gavagna, L Gaini, G Palumbo, P Capaccio, F Triulzi
Sudden sensorineural hearing loss is defined as acute hearing loss of the sensorineural type of at least 30 dB over 3 contiguous frequencies that occurs within a 72-hour period. Although many different causative factors have been proposed, sudden sensorineural hearing loss is still considered "idiopathic" in 71%-85% of cases, and treatments are empiric, not based on etiology. MR imaging implemented with a 3D FLAIR sequence has provided new insights into the etiology of sudden sensorineural hearing loss. Herein, we review the current management trends for patients with sudden sensorineural hearing loss, from the initial clinical diagnosis to therapeutic strategies and diagnostic work-up...
May 25, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28532971/clinical-and-audiological-characteristics-of-1000hz-audiometric-notch-patients
#14
Hyun-Min Lee, Seok-Hyun Kim, Jae-Hwan Jung, Se-Joon Oh, Soo-Keun Kong, Il-Woo Lee
PURPOSE: Among the hearing loss patients, we can confirm that the hearing loss of the specific frequency decreases, such as the 2000Hz notch in otosclerosis and the 4000Hz notch (c5-dip) in noise-induced hearing loss. The 1000Hz notch (c3-dip), however, is rarely studied. We fortuitously encountered a group of patients with a 1kHz hearing loss and report it with a review of the literature. METHODS: Otological history, audiogram, diagnosis, occupation, and history of noise exposure were reviewed from charts and telephone interview, and compared between c3-dip and c5-dip patients (n=98)...
April 1, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28530253/sensitivity-and-specificity-of-vestibular-bedside-examination-in-detecting-viii-cranial-nerve-schwannoma-with-sensorineural-sudden-unilateral-hearing-loss-as-presenting-symptom
#15
L Califano, F Salafia, M G Melillo, S Mazzone
The objectives of this study were to identify signs of vestibular nerve suffering through a bedside vestibular examination protocol in case of sudden sensorineural unilateral hearing loss without spontaneous signs of vestibular impairment and to propose a bed-side vestibular examination based protocol for the focused execution of gadolinium-enhanced magnetic resonance imaging (MRI) only if a vestibular schwannoma is suspected. 96 patients, 52 men, 44 women, mean age 57.73 +/- 12.85 years, suffering from sudden sensorineural unilateral hearing loss, which presented neither vertigo nor spontaneous nystagmus, were enrolled...
May 22, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28511890/intratympanic-steroid-delivery-by-an-indwelling-catheter-in-refractory-severe-sudden-sensorineural-hearing-loss
#16
Diego Zanetti, Federica Di Berardino, Nader Nassif, Luca Oscar Redaelli De Zinis
OBJECTIVE: Many studies over the last decade showed favorable outcomes with intratympanic (IT) steroid treatment, alone as salvage treatment or in combination with conventional systemic therapy (ST). However, in severe to profound sensorineural hearing loss resistant to ST, the optimal infusion mode, the type and concentration of the solution, the preferable drug, its total amount, and the duration and fractionation of the treatment are still debated. Aim of the study was to investigate the feasibility and the outcomes of a direct and constant IT delivery of dexamethasone (DEX) by means of a new indwelling catheter...
May 13, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28502595/a-sustained-increase-of-plasma-fibrinogen-in-sudden-sensorineural-hearing-loss-predicts-worse-outcome-independently
#17
Yoon Ah Park, Tae Hoon Kong, Young Joon Seo
OBJECTIVES: A number of etiologies of idiopathic sudden sensorineural hearing loss (ISSNHL) have been proposed. Vascular disturbance is one cause of ISSNHL and has been reported to be associated with fibrinogen. We aimed to determine whether hyperfibrinogenemia is associated with poor outcome and whether a serial change in fibrinogen level is associated with outcome. METHODS: Twenty-two patients with ISSNHL were enrolled. We compared the levels of fibrinogen in ISSNHL groups classified as improved and non-improved according to improvement of hearing...
May 5, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28499297/-diagnostics-and-therapy-of-idiopathic-sudden-sensorineural-hearing-loss
#18
Stefan K Plontke
This article reviews recent aspects of diagnostics, differential diagnostics and evidence in systemic and local therapy of idiopathic, sudden, sensorineural hearing loss (ISSHL). Since a number of disorders can be accompanied by sudden hearing loss a meaningful and targeted diagnostic strategy is of utmost importance. An important differential diagnosis of sudden hearing loss are intralabyrinthine schwannomas (ILS). The incidence of ILS is probably significantly underestimated. This may be due to the lack of awareness or lack of explicit search for an intralabyrinthine tumor on MRI or an inappropriate MRI technique ('head-MRI' instead of 'temporal bone-MRI' with too high slice thickness) for the evaluation of sudden hearing loss...
April 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28492865/the-relationship-between-iron-deficiency-anemia-and-sensorineural-hearing-loss-in-the-pediatric-and-adolescent-population
#19
Kathleen M Schieffer, James R Connor, James A Pawelczyk, Deepa L Sekhar
Purpose: A correlation between iron deficiency anemia (IDA) and sudden sensorineural hearing loss (SNHL) was described in adults. In this study, we examined if there is a relationship between IDA and hearing loss in the pediatric population. Method: This was a retrospective cohort study of data collected from the Informatics for Integrating Biology and the Bedside database from 2011 to 2016. Children and adolescents 4-21 years old seen at Penn State Milton S. Hershey Medical Center, Hershey, PA, were examined for hearing loss and IDA status...
June 13, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/28477092/-intracochlear-schwannoma-tumor-removal-via-subtotal-cochleoectomy-and-partial-cochlear-reconstruction-with-preservation-of-semicircular-canal-function-german-version
#20
S Plontke, S Kösling, N Pazaitis, T Rahne
We report about a patient who in 2005, aged 37 years, experienced sudden mild to moderate, mid-frequency sensorineural hearing loss in the right ear along with tinnitus and mild dizziness. MRI of the temporal bone revealed a very small (1 mm) contrast-enhancing lesion in the second turn of the right cochlea. Hearing gradually deteriorated with complete hearing loss in 2015. At this time, an MRI scan showed a lesion completely filling the cochlea.The tumor was removed via transmeatal subtotal cochleoectomy...
July 2017: HNO
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