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https://www.readbyqxmd.com/read/28104245/assessing-kinematics-and-kinetics-of-functional-electrical-stimulation-rowing
#1
Adina E Draghici, Glen Picard, J Andrew Taylor, Sandra J Shefelbine
Hybrid functional electrical stimulation (FES) rowing has positive effects on cardiovascular fitness, producing significantly greater aerobic power than either upper body or FES exercise alone. However, there is minimal information on the kinematics, kinetics, and mechanical efficiency of FES-rowing in the spinal cord injured (SCI) population. This study examined the biomechanics of FES-rowing to determine how motions, forces, and aerobic demand change with increasing intensity. Six individuals with SCI and six able-bodied subjects performed a progressive aerobic capacity rowing test...
January 7, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28099473/the-staphylococcus-aureus-srrab-regulatory-system-modulates-hydrogen-peroxide-resistance-factors-which-imparts-protection-to-aconitase-during-aerobic-growth
#2
Ameya A Mashruwala, Jeffrey M Boyd
The SrrAB two-component regulatory system (TCRS) positively influences the transcription of genes involved in aerobic respiration in response to changes in respiratory flux. Hydrogen peroxide (H2O2) can arise as a byproduct of spontaneous interactions between dioxygen and components of respiratory pathways. H2O2 damages cellular factors including protein associated iron-sulfur cluster prosthetic groups. We found that a Staphylococcus aureus strain lacking the SrrAB two-component regulatory system (TCRS) is sensitive to H2O2 intoxication...
2017: PloS One
https://www.readbyqxmd.com/read/28096988/successful-outcome-of-three-patients-with-sickle-cell-disease-and-fat-embolism-syndrome-treated-with-intensive-exchange-transfusion
#3
Paul Greaves, Vivek Mathew, Catherine Peters, Susan Rowe, Roger J Amos, Dimitris A Tsitsikas
Fat embolism syndrome (FES) is a rare complication of sickle-cell disease (SCD) associated with extremely high mortality rates. It affects predominantly non-SS patients and those with previously mild disease. Rapid institution of exchange transfusion with an aim to reduce HbS to very low levels as soon as FES is suspected can be life-saving.
January 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28095787/the-effects-of-habitual-functional-training-on-physical-functioning-in-patients-after-hip-fracture-the-protocol-of-the-hipfrac-study
#4
Kristi Elisabeth Heiberg, Vigdis Bruun-Olsen, Astrid Bergland
BACKGROUND: The survivors after hip fracture often report severe pain and loss of physical functioning. The poor outcomes cause negative impact on the person's physical functioning and quality of life and put a financial burden on society. Rehabilitation is important to improve physical functioning after hip fracture. To maintain the continuity in rehabilitation we have an assumption that it is of utmost importance to continue and progress the functional training that already started at the hospital, while the patients are transferred to short-term stays in a nursing home before they are returning to home...
January 17, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28088382/functional-electrical-stimulation-for-foot-drop-in-multiple-sclerosis-a-systematic-review-and-meta-analysis-of-the-impact-on-gait-speed
#5
REVIEW
Linda Miller, Angus McFadyen, Anna C Lord, Rebecca Hunter, Lorna Paul, Danny Rafferty, Roy Bowers, Paul Mattison
OBJECTIVE: To review the efficacy of functional electrical stimulation (FES) used for foot drop in people with multiple sclerosis (pwMS) on gait speed in short and long walking performance tests. DATA SOURCES: Five databases (Cochrane Library, CINAHL, Embase, MEDLINE, Pubmed) and reference lists were searched. STUDY SELECTION: Studies of both observational and experimental design where gait speed data in pwMS could be extracted were included...
January 11, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28078075/a-design-method-for-fes-bone-health-therapy-in-sci
#6
Brian Andrews, James Shippen, Monica Armengol, Robin Gibbons, William Holderbaum, William Harwin
FES assisted activities such as standing, walking, cycling and rowing induce forces within the leg bones and have been proposed to reduce osteoporosis in spinal cord injury (SCI). However, details of the applied mechanical stimulus for osteogenesis is often not reported. Typically, comparisons of bone density results are made after costly and time consuming clinical trials. These studies have produced inconsistent results and are subject to sample size variations. Here we propose a design process that may be used to predict the clinical outcome based on biomechanical simulation and mechano-biology...
September 15, 2016: European Journal of Translational Myology
https://www.readbyqxmd.com/read/28078074/fes-in-europe-and-beyond-current-translational-research
#7
Christine Azevedo Coste, Winfried Mayr, Manfred Bijak, Antonio Musarò, Ugo Carraro
Capacity of adult neural and muscle tissues to respond to external Electrical Stimulation (ES) is the biological basis for the development and implementation of mobility impairment physiotherapy protocols and of related assistive technologies, e.g, Functional Electrical Stimulation (FES). All body tissues, however, respond to electrical stimulation and, indeed, the most successful application of FES is electrical stimulation of the heart to revert or limit effects of arrhythmias (Pace-makers and Defibrillators)...
September 15, 2016: European Journal of Translational Myology
https://www.readbyqxmd.com/read/28078072/multisensor-classification-system-for-triggering-fes-in-order-to-support-voluntary-swallowing
#8
Benjamin Riebold, Holger Nahrstaedt, Corinna Schultheiss, Rainer O Seidl, Thomas Schauer
In dysphagia the ability of elevating the larynx and hyoid is usually impaired. Electromyography (EMG) and Bioimpedance (BI) measurements at the neck can be used to trigger functional electrical stimulation (FES) of swallowing related muscles. Nahrstaedt et al.(1) introduced an algorithm to trigger the stimulation in phase with the voluntary swallowing to improve the airway closure and elevation speed of the larynx and hyoid. However, due to non-swallow related movements like speaking, chewing or head turning, stimulations might be unintentionally triggered...
September 15, 2016: European Journal of Translational Myology
https://www.readbyqxmd.com/read/28078071/electrical-stimulation-to-reduce-the-overload-in-upper-limbs-during-sitting-pivot-transfer-in-paraplegic-a-preliminary-study
#9
Ana Claudia G Lopes, Claudia Ochoa-Diaz, Roberto S Baptista, Lucas O Fonseca, Charles Fattal, Christine Azevedo Coste, Antônio P L Bó, Emerson Fachin-Martins
Transfer is a key ability and allows greater interact with the environment and social participation. Conversely, paraplegics have great risk of pain and injury in the upper limbs due to joint overloads during activities of daily living, like transfer. The main goal of this study is to verify if the use of functional electrical stimulation (FES) in the lower limbs of paraplegic individuals can assist the sitting pivot transfer (SPT). The secondary objective is to verify if there is a greater participation of the lower limbs during lift pivot phase...
September 15, 2016: European Journal of Translational Myology
https://www.readbyqxmd.com/read/28078068/efficacy-of-emg-bioimpedance-triggered-functional-electrical-stimulation-on-swallowing-performance
#10
Corinna Schultheiss, Thomas Schauer, Holger Nahrstaedt, Rainer O Seidl, Jehoschua Bieler
In order to support swallowing, the efficacy of functional electrical stimulation for different stimulation settings of the submental musculature has been investigated. The stimulation was administrated at rest and synchronously to voluntary initiated swallows. The onset of a swallow was detected in real-time by a combined electromyography/ bioimpedance measurement at the neck in order to trigger the stimulation. The amplitude and speed of larynx elevation caused by the FES has been assessed by the observed change in bioimpedance whereas a reduction of bioimpedance corresponds to an increase in larynx elevation...
September 15, 2016: European Journal of Translational Myology
https://www.readbyqxmd.com/read/28078066/use-it-or-lose-it-tonic-activity-of-slow-motoneurons-promotes-their-survival-and-preferentially-increases-slow-fiber-type-groupings-in-muscles-of-old-lifelong-recreational-sportsmen
#11
Simone Mosole, Ugo Carraro, Helmut Kern, Stefan Loefler, Sandra Zampieri
: Histochemistry, immuno-histochemistry, gel electrophoresis of single muscle fibers and electromyography of aging muscles and nerves suggest that: i) denervation contributes to muscle atrophy, ii) impaired mobility accelerates the process, and iii) lifelong running protects against loss of motor units. Recent corroborating results on the muscle effects of Functional Electrical Stimulation (FES) of aged muscles will be also mentioned, but we will in particular discuss how and why a lifelong increased physical activity sustains reinnervation of muscle fibers...
September 15, 2016: European Journal of Translational Myology
https://www.readbyqxmd.com/read/28077603/influence-of-focus-of-attention-reinvestment-and-fall-history-on-elderly-gait-stability
#12
Jonathan L A de Melker Worms, John F Stins, Erwin E H van Wegen, Ian D Loram, Peter J Beek
Falls represent a substantial risk in the elderly. Previous studies have found that a focus on the outcome or effect of the movement (external focus of attention) leads to improved balance performance, whereas a focus on the movement execution itself (internal focus of attention) impairs balance performance in elderly. A shift toward more conscious, explicit forms of motor control occurs when existing declarative knowledge is recruited in motor control, a phenomenon called reinvestment. We investigated the effects of attentional focus and reinvestment on gait stability in elderly fallers and nonfallers...
January 2017: Physiological Reports
https://www.readbyqxmd.com/read/28071962/the-feasibility-of-functional-electrical-stimulation-to-improve-upper-extremity-function-in-a-two-year-old-child-with-perinatal-stroke-a-case-report
#13
Kristin E Musselman, Patricia Manns, Jaclyn Dawe, Rhina Delgado, Jaynie F Yang
AIMS: To evaluate the effectiveness and feasibility (i.e. tolerability, adherence) of functional electrical stimulation (FES) for the upper extremity (UE) in a two-year-old child with perinatal stroke. METHODS: Forty hours of FES over eight weeks was prescribed. FES to the hemiplegic triceps, extensor carpi radialis longus and brevis, extensor carpi ulnaris and extensor digitorum was timed with reaching during play. Assessments were performed before, during, and two months post-intervention...
January 10, 2017: Physical & Occupational Therapy in Pediatrics
https://www.readbyqxmd.com/read/28067774/distal-fes-cluster-coordination-in-nife-hydrogenase-facilitates-intermolecular-electron-transfer
#14
Alexander Petrenko, Matthias Stein
Biohydrogen is a versatile energy carrier for the generation of electric energy from renewable sources. Hydrogenases can be used in enzymatic fuel cells to oxidize dihydrogen. The rate of electron transfer (ET) at the anodic side between the [NiFe]-hydrogenase enzyme distal iron-sulfur cluster and the electrode surface can be described by the Marcus equation. All parameters for the Marcus equation are accessible from Density Functional Theory (DFT) calculations. The distal cubane FeS-cluster has a three-cysteine and one-histidine coordination [Fe₄S₄](His)(Cys)₃ first ligation sphere...
January 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28062290/virulence-related-genes-adhesion-and-invasion-of-some-yersinia-enterocolitica-like-strains-suggests-its-pathogenic-potential
#15
Priscilla F M Imori, Jaqueline Passaglia, Roberto A Souza, Lenaldo B Rocha, Juliana P Falcão
Yersina enterocolitica-like species have not been extensively studied regarding its pathogenic potential. This work aimed to assess the pathogenic potential of some Y. enterocolitica-like strains by evaluating the presence of virulence-related genes by PCR and their ability to adhere to and invade Caco-2 and HEp-2 cells. A total of 50 Y. frederiksenii, 55 Y. intermedia and 13 Y. kristensenii strains were studied. The strains contained the following genes: Y. frederiksenii, fepA(44%), fes(44%) and ystB(18%); Y...
January 3, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28052666/free-energy-landscape-of-protein-ligand-interactions-coupled-with-protein-structural-changes
#16
Kei Moritsugu, Tohru Terada, Akinori Kidera
Protein-ligand interactions are frequently coupled with protein structural changes. Focusing on the coupling, we present the free-energy surface (FES) of the ligand-binding process for glutamine-binding protein (GlnBP) and its ligand, glutamine, in which glutamine binding accompanies large-scale domain closure. All-atom simulations were performed in explicit solvents by multiscale enhanced sampling (MSES), which adopts a multicopy and multiscale scheme to achieve enhanced sampling of systems with a large number of degrees of freedom...
January 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28043980/fear-of-falling-and-its-association-with-life-space-mobility-of-older-adults-a-cross-sectional-analysis-using-data-from-five-international-sites
#17
Mohammad Auais, Beatriz Alvarado, Ricardo Guerra, Carmen Curcio, Ellen E Freeman, Alban Ylli, Jack Guralnik, Nandini Deshpande
BACKGROUND: fear of falling (FOF) is a major health concern among community-dwelling older adults that could restrict mobility. OBJECTIVE: to examine the association of FOF with life-space mobility (i.e. the spatial area a person moves through in daily life) of community-dwelling older adults from five diverse sites. METHODS: in total, 1,841 older adults (65-74 years) were recruited from Kingston, Canada; Saint-Hyacinthe, Canada; Tirana, Albania; Manizales, Colombia and Natal, Brazil...
January 1, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28031527/tumor-initiating-cells-of-breast-and-prostate-origin-show-alterations-in-the-expression-of-genes-related-to-iron-metabolism
#18
Zuzana Rychtarcikova, Sandra Lettlova, Veronika Tomkova, Vlasta Korenkova, Lucie Langerova, Ekaterina Simonova, Polina Zjablovskaja, Meritxell Alberich-Jorda, Jiri Neuzil, Jaroslav Truksa
The importance of iron in the growth and progression of tumors has been widely documented. In this report, we show that tumor-initiating cells (TICs), represented by spheres derived from the MCF7 cell line, exhibit higher intracellular labile iron pool, mitochondrial iron accumulation and are more susceptible to iron chelation. TICs also show activation of the IRP/IRE system, leading to higher iron uptake and decrease in iron storage, suggesting that level of properly assembled cytosolic iron-sulfur clusters (FeS) is reduced...
December 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/28025356/graded-activity-for-older-adults-with-chronic-low-back-pain-program-development-and-mixed-methods-feasibility-cohort-study
#19
Katrin Kuss, Corinna Leonhardt, Sabine Quint, Dagmar Seeger, Michael Pfingsten, Udo Wolf Pt, Heinz-Dieter Basler, Annette Becker
BACKGROUND: Persistent pain is highly prevalent in older adults and can lead to functional limitations in activities of daily living, and to psychosocial distress. There is a lack of established active therapy programs, especially for older adults with chronic pain. OBJECTIVES: To develop a graded activity program and to evaluate its feasibility within a pilot study. DESIGN: Phase I/phase II trial of a complex intervention. A mixed methods design was chosen to evaluate the feasibility, acceptability, and preliminary evidence of effectiveness...
December 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28018240/distinctive-steady-state-heart-rate-and-blood-pressure-responses-to-passive-robotic-leg-exercise-and-functional-electrical-stimulation-during-head-up-tilt
#20
Amirehsan Sarabadani Tafreshi, Robert Riener, Verena Klamroth-Marganska
Introduction: Tilt tables enable early mobilization of patients by providing verticalization. But there is a high risk of orthostatic hypotension provoked by verticalization, especially after neurological diseases such as spinal cord injury. Robot-assisted tilt tables might be an alternative as they add passive robotic leg exercise (PE) that can be enhanced with functional electrical stimulation (FES) to the verticalization, thus reducing the risk of orthostatic hypotension. We hypothesized that the influence of PE on the cardiovascular system during verticalization (i...
2016: Frontiers in Physiology
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