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https://www.readbyqxmd.com/read/28791083/epidemiology-of-first-epileptic-seizures-in-the-northern-aegean-island-of-lesvos-greece
#1
Anastasia Verentzioti, George Stranjalis, Theodosis Kalamatianos, Anna Siatouni, Damianos E Sakas, Stylianos Gatzonis
We aimed at establishing the epidemiologic profile of first epileptic seizures (FES) in the Greek island of Lesvos. During a 1-year period (01/06/2010 to 31/05/2011), cases of FES admitted to the Lesvos General Hospital/addressed by general practitioners/private neurologists were prospectively identified. A total of 45 cases (30 males and 15 females; mean age ± SD of 59.4 ± 28.4 and 58.9 ± 26.8 years, respectively), were collected. The FES incidence rate was 52.1 (95% CI 37-67) per 10(5) persons. Provoked and unprovoked FES had an incidence of, 16...
June 7, 2017: Clinics and Practice
https://www.readbyqxmd.com/read/28790351/whole-transcriptome-profiling-of-taste-bud-cells
#2
Sunil K Sukumaran, Brian C Lewandowski, Yumei Qin, Ramana Kotha, Alexander A Bachmanov, Robert F Margolskee
Analysis of single-cell RNA-Seq data can provide insights into the specific functions of individual cell types that compose complex tissues. Here, we examined gene expression in two distinct subpopulations of mouse taste cells: Tas1r3-expressing type II cells and physiologically identified type III cells. Our RNA-Seq libraries met high quality control standards and accurately captured differential expression of marker genes for type II (e.g. the Tas1r genes, Plcb2, Trpm5) and type III (e.g. Pkd2l1, Ncam, Snap25) taste cells...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28773837/one-step-synthesis-of-single-wall-carbon-nanotube-zns-core-shell-nanocables
#3
Yanli Zhang, Xiangming He, Li Wang, Jian Gao, Jianjun Li
Nanocables with a single-wall carbon nanotube (SWCNT) core and a ZnS shell were directly synthesized in one step through a thermal reaction method by using carbon, Zn, and FeS powder as starting materials. The as-fabricated nanocables were studied using scanning electron microscopy, transmission electron microscopy, and Raman spectroscopy. The nanocables have diameters of ~50 nm, lengths of several micrometers, and shell thickness of ~20 nm. TEM analysis revealed that the shell is polycrystalline wurtzite-type ZnS with good crystallinity, and the core of the nanocables is one to several SWCNTs...
August 24, 2016: Materials
https://www.readbyqxmd.com/read/28770220/transcriptome-based-modeling-reveals-that-oxidative-stress-induces-modulation-of-the-atfa-dependent-signaling-networks-in-aspergillus-nidulans
#4
Erzsébet Orosz, Károly Antal, Zoltán Gazdag, Zsuzsa Szabó, Kap-Hoon Han, Jae-Hyuk Yu, István Pócsi, Tamás Emri
To better understand the molecular functions of the master stress-response regulator AtfA in Aspergillus nidulans, transcriptomic analyses of the atfA null mutant and the appropriate control strains exposed to menadione sodium bisulfite- (MSB-), t-butylhydroperoxide- and diamide-induced oxidative stresses were performed. Several elements of oxidative stress response were differentially expressed. Many of them, including the downregulation of the mitotic cell cycle, as the MSB stress-specific upregulation of FeS cluster assembly and the MSB stress-specific downregulation of nitrate reduction, tricarboxylic acid cycle, and ER to Golgi vesicle-mediated transport, showed AtfA dependence...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/28769885/novel-pelagic-iron-oxidizing-zetaproteobacteria-from-the-chesapeake-bay-oxic-anoxic-transition-zone
#5
Beverly K Chiu, Shingo Kato, Sean M McAllister, Erin K Field, Clara S Chan
Chemolithotrophic iron-oxidizing bacteria (FeOB) could theoretically inhabit any environment where Fe(II) and O2 (or nitrate) coexist. Until recently, marine Fe-oxidizing Zetaproteobacteria had primarily been observed in benthic and subsurface settings, but not redox-stratified water columns. This may be due to the challenges that a pelagic lifestyle would pose for Zetaproteobacteria, given low Fe(II) concentrations in modern marine waters and the possibility that Fe oxyhydroxide biominerals could cause cells to sink...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28766617/hydrothermal-assembly-structures-topologies-luminescence-and-magnetism-of-a-novel-series-of-coordination-polymers-driven-by-a-trifunctional-nicotinic-acid-building-block
#6
Jin-Zhong Gu, Xiao-Xiao Liang, Yan Cai, Jiang Wu, Zi-Fa Shi, Alexander M Kirillov
In this work, a trifunctional N,O-building block, 5-(4-carboxyphenoxy)nicotinic acid (H2cpna), that combines three distinct types of functional groups (COOH, N-pyridyl, and O-ether) was used for the hydrothermal assembly of thirteen new coordination compounds: [Co(μ3-Hcpna)2]n (1), [Mn(μ4-cpna)(H2O)]n (2), [Mn(μ4-cpna)(H2O)2]n (3), [Mn(μ-cpna)(2,2'-bipy)(H2O)2]n (4), {[Ni(μ3-cpna)(2,2'-bipy)(H2O)]2·H2O}n (5), {[Cd(μ3-cpna)(2,2'-bipy)]·2H2O}n (6), [Zn2(μ-cpna)2(2,2'-bipy)2] (7), [Cu(μ-cpna)(2,2'-bipy)(H2O)]n (8), {[Mn(μ-cpna)(phen)2]·6H2O}n (9), {[Ni(μ3-cpna)(phen)(H2O)]·H2O}n (10), [Zn2(μ-cpna)2(phen)2] (11), {[Pb(μ3-cpna)(phen)]·H2O}n (12), and [Ni(μ3-cpna)(4,4'-bipy)0...
August 2, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28766335/functional-complementation-studies-reveal-different-interaction-partners-of-escherichia-coli-iscs-and-human-nfs1
#7
Martin Bühning, Martin Friemel, Silke Leimkühler
The trafficking and delivery of sulfur to cofactors and nucleosides is a highly regulated and conserved process among all organisms. All sulfur transfer pathways have generally an L-cysteine desulfurase as initial sulfur-mobilizing enzyme in common, which serves as sulfur donor for the biosynthesis of sulfur-containing biomolecules like iron-sulfur (FeS) clusters, thiamine, biotin, lipoic acid, the molybdenum cofactor (Moco), and thiolated nucleosides in tRNA. The human L-cysteine desulfurase NFS1 and the Escherichia coli homologue IscS share an amino acid sequence identity of about 60%...
August 2, 2017: Biochemistry
https://www.readbyqxmd.com/read/28762503/mechanomyography-based-wearable-monitor-of-quasi-isometric-muscle-fatigue-for-motor-neural-prostheses
#8
Eddy Krueger, Lana Popović-Maneski, Percy Nohama
A motor neural prosthesis based on surface functional electrical stimulation (sFES) can restore functional movement (e.g., standing, walking) in patients with a spinal cord injury (SCI). sFES generates muscle contractions in antigravity muscles and allows balance-assisted standing. This induced standing has several benefits, such as improved cardiovascular function, decreased incidence of urinary infections, reduced joint contractures, and muscle atrophy. The duration of sFES assisted standing is limited due to the quick onset of muscle fatigue...
August 1, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28756887/-results-of-bronchiectasis-surgery-about-64%C3%A2-cases
#9
S Rabiou, I Issoufou, F Z Ammor, H Harmouchi, L Belliraj, M Lakranbi, M Serraj, Y Ouadnouni, M Smahi
INTRODUCTION: Bronchiectasis is a serious and disabling disease. Surgical treatment is an interesting alternative to be proposed early to patients in case of complications or deterioration of quality of life, despite an optimal medical treatment. Through this retrospective study and literature review, we analyze surgical results for bronchiectasis. PATIENTS AND METHOD: We conducted a monocentric, retrospective, descriptive and analytical study in the Department of thoracic surgery of CHU Hassan II Fès, about 64 patients operated for bronchiectasis during the period from January 2009 to December 2016...
July 27, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/28754840/over-expression-of-the-rieskefes-protein-increases-electron-transport-rates-and-biomass-yield
#10
Andrew John Simkin, Lorna McAusland, Tracy Lawson, Christine A Raines
In this study we have generated transgenic Arabidopsis plants over-expressing the Rieske FeS protein (PetC), a component of the cytochrome b6f (cyt b6f) complex. Increasing the levels of this protein, resulted in the concomitant increase in the levels of cyt f (PetA) and cyt b6 (PetB), core proteins of the cyt b6f complex. Interestingly, an increase in the levels of proteins in both the PSI and PSII complexes was also seen in the Rieske FeS ox plants. Although the mechanisms leading to these changes remain to be identified, the transgenic plants presented here provide novel tools to explore this...
July 28, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28745900/full-wave-function-optimization-with-quantum-monte-carlo-and-its-effect-on-the-dissociation-energy-of-fes
#11
Kaveh Haghighi Mood, Arne Lüchow
Diffusion quantum Monte Carlo calculations with partial and full optimization of the guide function are carried out for the dissociation of the FeS molecule. For the first time, quantum Monte Carlo orbital optimization for transition metal compounds is performed. It is demonstrated that energy optimization of the orbitals of a complete active space wave function in the presence of a Jastrow correlation function is required to obtain agreement with the experimental dissociation energy. Furthermore, it is shown that orbital optimization leads to a (5)Δ ground state, in agreement with experiments but in disagreement with other high-level ab initio wave function calculations which all predict a (5)Σ(+) ground state...
August 7, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28744044/the-effects-of-occupation-centered-activity-program-on-fall-related-factors-and-quality-of-life-in-patients-with-dementia
#12
Ko-Un Kim, Soo-Han Kim, Hye-Won Oh
[Purpose] The purpose of this study was to investigate the effects of an occupation-centered activity program for dementia patients living in a local community, and examined the effects of the occupation-centered activity program on their cognitive functions, fall-related factors, and quality of life. [Subjects and Methods] Thirty subjects were divided into two groups: the experiment group (n=15) and the control group (n=15). The occupation-centered activity program was then applied to dementia patients for 60 minutes, 5 times/week for 12 weeks...
July 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28740824/associations-between-daily-living-skills-cognition-and-real-world-functioning-across-stages-of-schizophrenia-a-study-with-the-schizophrenia-cognition-rating-scale-japanese-version
#13
Yuko Higuchi, Tomiki Sumiyoshi, Tomonori Seo, Motomu Suga, Tsutomu Takahashi, Shimako Nishiyama, Yuko Komori, Kiyoto Kasai, Michio Suzuki
Cognitive function is impaired in patients with schizophrenia-spectrum disorders, even in their prodromal stages. Specifically, the assessment of cognitive abilities related to daily-living functioning, or functional capacity, is important to predict long-term outcome. In this study, we sought to determine the validity of the Schizophrenia Cognition Rating Scale (SCoRS) Japanese version, an interview-based measure of cognition relevant to functional capacity (i.e. co-primary measure). For this purpose, we examined the relationship of SCoRS scores with performance on the Brief Assessment of Cognition in Schizophrenia (BACS) Japanese version, a standard neuropsychological test battery, and the Social and Occupational Functioning Assessment Scale (SOFAS), an interview-based social function scale...
March 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28727840/dual-inhibition-of-fes-and-flt3-tyrosine-kinases-potently-inhibits-flt3-itd-aml-cell-growth
#14
Mark C Weir, Sabine Hellwig, Li Tan, Yao Liu, Nathanael S Gray, Thomas E Smithgall
Acute myelogenous leukemia (AML) is often associated with activating mutations in the receptor tyrosine kinase, Flt3, including internal tandem duplications (ITDs) within the regulatory juxtamembrane region. Previous studies have linked Flt3-ITD to the activation of the Fes protein tyrosine kinase in AML, and RNAi-knockdown studies suggest that Fes may be required for Flt3 function. In this study, we tested Fes inhibitors from three different chemical classes for their growth-suppressive activity against Flt3-ITD+ myeloid leukemia cell lines (MV4-11, MOLM-13 and MOLM-14) vs...
2017: PloS One
https://www.readbyqxmd.com/read/28724204/gait-and-balance-impairment-after-acute-methanol-poisoning
#15
Kamila Peterová, Hana Brožová, Jiří Klempíř, Irena Lišková, Ondřej Bezdíček, Petr Ridzoň, Manuela Vaněčková, Sergej Zakharov, Daniela Pelclová, Michal Miovský, Evžen Růžička
Neurological sequelae including gait impairment were reported in survivors after methanol intoxication; however, no systematic study has been published so far. We aimed to analyse gait and balance impairment in a group of Czech methanol poisoning survivors. We examined 43 patients (age 46±13 years) 2-8 months after methanol poisoning and 43 healthy controls. Investigations contained a shortened version of Falls Efficacy Scale (FES), clinical tests of gait and balance including Timed Up and Go test (TUG) and gait analysis using GaitRite(®) system, neurological and neuropsychological examination, brain imaging, EMG and tests of alcohol consumption...
July 19, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28721429/frailty-and-fear-of-falling-the-fistac-study
#16
M Esbrí-Víctor, I Huedo-Rodenas, M López-Utiel, J L Navarro-López, M Martínez-Reig, J A Serra-Rexach, L Romero-Rizos, P Abizanda
OBJECTIVE: To analyze the association between frailty and Fear of Falling (FoF) in a cohort of older adults with previous falls. DESIGN: Cross-sectional study (FISTAC). SETTING: Falls Unit, Complejo Hospitalario Universitario of Albacete (Spain). PARTICIPANTS: 183 adults older than 69 years, from the Falls Unit, with a history of a previous fall in the last year. MEASUREMENTS: FoF was assessed at baseline using the Falls Efficacy Scale International (FES-I) and three questions previously validated...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/28715755/adsorption-of-mercury-ii-from-aqueous-solutions-using-fes-and-pyrite-a-comparative-study
#17
Yue Sun, Dan Lv, Jiasheng Zhou, Xiaoxin Zhou, Zimo Lou, Shams Ali Baig, Xinhua Xu
In this study, a comparative evaluation of synthetic FeS and natural pyrite was performed to investigate their adsorptive potentials toward Hg(II) in aqueous system. Characterization analyses such as BET, SEM and TEM suggested that FeS had porous structures with abundant active sites, while pyrite with a hard and smooth surface relied mainly on surface adsorption to immobilize Hg(II). Results of batch tests revealed that FeS offered much greater Hg(II) maximum adsorption capacity (769.2 mg/g) as compared to pyrite (9...
July 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/28715333/wheelchair-neuroprosthesis-for-improving-dynamic-trunk-stability
#18
Kramay Patel, Matija Milosevic, Kimitaka Nakazawa, Milos R Popovic, Kei Masani
Trunk instability is a major problem for individuals with thoracic and cervical spinal cord injury. Functional electrical stimulation (FES) neuroprosthesis, a technology that uses small electrical currents to artificially contract muscles, has previously been utilized to improve trunk stability during quasistatic and dynamic sitting. The aim of this study was to develop the first powered wheelchair-based neuroprosthesis and to test its feasibility for improving trunk stability. Eleven male, able-bodied individuals participated in the feasibility study...
July 14, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28714802/binocular-vision-disorders-and-visual-attention-associations-with-balance-and-mobility-in-older-adults
#19
Mohammed M Althomali, Susan J Leat
Understanding which aspects of vision are related to falls is important. We examine the associations between tests of balance, mobility, fear of falling (FES-1) and aspects of vision in 72 adults aged 70+. Balance and mobility were examined using the One Legged Stance test (OLST), the Sit to Stand test (STST) and the 5 Meter Walking test (5MWT). Visual measures included visual acuity (VA), contrast sensitivity, stereoacuity, binocular vision (BV) measurements, Useful field of View (UFV) and Attended Field of View (AFOV)...
July 17, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28708068/mechanomyography-and-torque-during-fes-evoked-muscle-contractions-to-fatigue-in-individuals-with-spinal-cord-injury
#20
Nor Zainah Mohamad, Nur Azah Hamzaid, Glen M Davis, Ahmad Khairi Abdul Wahab, Nazirah Hasnan
A mechanomyography muscle contraction (MC) sensor, affixed to the skin surface, was used to quantify muscle tension during repetitive functional electrical stimulation (FES)-evoked isometric rectus femoris contractions to fatigue in individuals with spinal cord injury (SCI). Nine persons with motor complete SCI were seated on a commercial muscle dynamometer that quantified peak torque and average torque outputs, while measurements from the MC sensor were simultaneously recorded. MC-sensor-predicted measures of dynamometer torques, including the signal peak (SP) and signal average (SA), were highly associated with isometric knee extension peak torque (SP: r = 0...
July 14, 2017: Sensors
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