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https://www.readbyqxmd.com/read/29148137/brain-computer-interfaces-with-multi-sensory-feedback-for-stroke-rehabilitation-a-case-study
#1
Danut C Irimia, Woosang Cho, Rupert Ortner, Brendan Z Allison, Bogdan E Ignat, Guenter Edlinger, Christoph Guger
Conventional therapies do not provide paralyzed patients with closed-loop sensorimotor integration for motor rehabilitation. This work presents the recoveriX system, a hardware and software platform that combines a motor imagery (MI)-based brain-computer interface (BCI), functional electrical stimulation (FES), and visual feedback technologies for a complete sensorimotor closed-loop therapy system for poststroke rehabilitation. The proposed system was tested on two chronic stroke patients in a clinical environment...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/29148129/development-of-functional-electrical-stimulation-rowing-the-rowstim-series
#2
Brian Andrews, Robin Gibbons, Garry Wheeler
Potentially, functional electrical stimulation (FES)-assisted exercise may have an important therapeutic role in reducing comorbidities associated with spinal cord injury (SCI). Here, we present an overview of these secondary life-threatening conditions, discuss the rationale behind the development of a hybrid exercise called FES rowing, and describe our experience in developing FES rowing technology. FES rowing and sculling are unique forms of adaptive rowing for those with SCI. The paralyzed leg musculature is activated by multiple channels of electrical pulses delivered via self-adhesive electrodes attached to the skin...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/29148128/step-ergometer-training-augmented-with-functional-electrical-stimulation-in-individuals-with-chronic-spinal-cord-injury-a-feasibility-study
#3
Candy Tefertiller, Don Gerber
Spinal cord injury (SCI) often results in loss of upright mobility and independence subsequently challenging rehabilitation practitioners for meaningful intervention strategies. The objective of this study was to evaluate the feasibility and potential impact on walking function of the stimulation and ergometer training protocol (STEP) in chronic SCI. Fourteen individuals with a chronic motor incomplete SCI (>1-year post injury) were enrolled in the study. The intervention consisted of a 12-week walking training program delivered three times per week from 20 up to 45 min in combination with 10 channels of FES on a step ergometer...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/29145921/change-in-fear-of-falling-in-parkinson-s-disease-a-two-year-prospective-cohort-study
#4
Tatjana Gazibara, Darija Kisic Tepavcevic, Marina Svetel, Aleksandra Tomic, Iva Stankovic, Vladimir S Kostic, Tatjana Pekmezovic
BACKGROUND: Fear of falling in Parkinson's disease (PD) has been suggested as predictor of future falling. The purpose of this study was to compare fear of falling score after two years of follow-up with those observed at baseline and to assess factors associated with change in fear of falling over time. METHODS: A total of 120 consecutive persons with PD were recruited and followed for two years. Fear of falling was assessed by using the 10-item Falls Efficacy Scale (FES)...
November 17, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29136466/multiconfiguration-pair-density-functional-theory-and-complete-active-space-second-order-perturbation-theory-bond-dissociation-energies-of-fec-nic-fes-nis-fese-and-nise
#5
Kamal Sharkas, Laura Gagliardi, Donald G Truhlar
We investigate the performance of multi-configuration pair-density functional theory (MC-PDFT) and complete active space second-order perturbation theory for computing the bond dissociation energies of the diatomic molecules FeC, NiC, FeS, NiS, FeSe, and NiSe, for which accurate experimental data have become recently available [Matthew, D. J.; Tieu, E.; Morse, M. D. J. Chem. Phys. 2017, 146, 144310]. We use three correlated participating orbitals (CPO) schemes (nominal, moderate, and extended) to define the active spaces (CAS), and we consider both the complete active space (CAS) and the separated-pair (SP) schemes to specific the configurations included for a given active space...
November 14, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29132482/effectiveness-of-functional-electrical-stimulation-fes-versus-conventional-electrical-stimulation-in-gait-rehabilitation-of-patients-with-stroke
#6
Freeha Sharif, Samina Ghulam, Arshad Nawaz Malik, Quratulain Saeed
OBJECTIVE: To compare the effectiveness of functional electrical stimulation (FES) versus conventional electrical stimulation in gait rehabilitation of patients with stroke for finding the most appropriate problem-oriented treatment for foot drop patients in a shorter time period. STUDY DESIGN: Randomized controlled trial. PLACE AND DURATION OF STUDY: Armed Forces Institute of Rehabilitation Medicine, Rawalpindi, from July to December 2016...
November 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29126372/exercise-improves-recognition-memory-and-synaptic-plasticity-in-the-prefrontal-cortex-for-rats-modelling-vascular-dementia
#7
Juntao Dong, Jingpu Zhao, Yangyang Lin, Huiying Liang, Xiaokuo He, Xiuyuan Zheng, Minghong Sui, Zhiqiang Zhuang, Tiebin Yan
OBJECTIVES: Functional electrical stimulation (FES) may induce involuntary exercise and make beneficial effects on vascular dementia (VD) by strengthening the BDNF-pCREB-mediated pathway and hippocampal plasticity. Whether FES improves recognition memory and synaptic plasticity in the prefrontal cortex (PFC) was investigated by establishing a VD model. METHODS: The VD rats were administered with two weeks of voluntary exercise, forced exercise, or involuntary exercise induced with FES...
November 10, 2017: Neurological Research
https://www.readbyqxmd.com/read/29124426/molecular-chaperones-involved-in-mitochondrial-iron-sulfur-protein-biogenesis
#8
REVIEW
Rafal Dutkiewicz, Malgorzata Nowak
Iron-sulfur (FeS) clusters are prosthetic groups critical for the function of many proteins in all domains of life. FeS proteins function in processes ranging from oxidative phosphorylation and cofactor biosyntheses to DNA/RNA metabolism and regulation of gene expression. In eukaryotic cells, mitochondria play a central role in the process of FeS biogenesis and support maturation of FeS proteins localized within mitochondria and in other cellular compartments. In humans, defects in mitochondrial FeS cluster biogenesis lead to numerous pathologies, which are often fatal...
November 9, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29120633/neural-network-based-prediction-of-conformational-free-energies-a-new-route-towards-coarse-grained-simulation-models
#9
Tobias Lemke, Christine Peter
Coarse-grained (CG) simulation models have become very popular tools to study complex molecular systems with great computational efficiency on length and timescales that are inaccessible to simulations at atomistic resolution. In so-called bottom up coarse-graining strategies, the interactions in the CG model are devised such that an accurate representation of an atomistic sampling of configurational phase space is achieved. This means the coarse-graining methods use the underlying multibody potential of mean force (i...
November 9, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29118956/the-vienna-fes-interview-protocol-a-mixed-methods-protocol-to-elucidate-the-opinions-of-various-individuals-responsible-for-the-provision-of-fes-exercise
#10
Matthew J Taylor, Ché Fornusek, Andrew J Ruys, Manfred Bijak, Adrian E Bauman
Functional Electrical Stimulation (FES) is the production of electrically elicited muscle contractions to perform a function or task. It has been used as a method to regain lost body functions or support weak body functions, and as such, has been clinically available since the early seventies. Some methods are applied routinely while others have not been translated to the bedside, or are still largely restricted to laboratory use. Progress in this field might be achieved by a strong cooperation of patients, clinicians, therapists and engineers...
June 27, 2017: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29110892/behaviour-of-trace-metals-in-the-anoxic-environment-of-veraval-harbour-india
#11
Divya Majithiya, Ajay Yadav, Anirudh Ram
The purpose of the present study is to investigate the behaviour of trace metals in anoxic environment. Water column of the harbour was found to be anoxic (DO <0.2mgl(-1)) with high concentration of NH4(+)-N (av. 459±21μmoll(-1)) and H2S (av.73±2.5μmoll(-1)) irrespective of season and tide. High concentrations of Fe, Mn in bottom water indicated that Fe, Mn were diagenetically mobilized under the anoxic conditions prevailing in the harbour. In harbour sediments significant correlation of metals with TOC and TS indicated their diagenetic immobilization in anoxic environment...
October 27, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29108660/usefulness-of-electroencephalography-for-the-management-of-epilepsy-in-emergency-departments
#12
A Viloria Alebesque, A López Bravo, E Bellosta Diago, S Santos Lasaosa, J A Mauri Llerda
INTRODUCTION: Electroencephalography (EEG) is an essential diagnostic tool in epilepsy. Its use in emergency departments (ED) is usually restricted to the diagnosis and management of non-convulsive status epilepticus (NCSE). However, EDs may also benefit from EEG in the context of other situations in epilepsy. METHODS: We conducted a retrospective observational study using the clinical histories of patients treated at our hospital's ED for epileptic seizures and suspicion of NCSE and undergoing EEG studies in 2015 and 2016...
November 3, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29108487/a-clinically-meaningful-training-effect-in-walking-speed-using-functional-electrical-stimulation-for-motor-incomplete-spinal-cord-injury
#13
Tamsyn Street, Christine Singleton
CONTEXT/OBJECTIVE: The study aimed to investigate the presence of a training effect for rehabilitation of walking function in motor-incomplete spinal cord injury (SCI) through daily use of functional electrical stimulation (FES). SETTING: A specialist FES outpatient centre Participants: Thirty-five participants (mean age 53, SD 15, range 18-80; mean years since diagnosis 9, range 5 months - 39 years) with drop foot and motor-incomplete SCI (T12 or higher, ASIA Impairment Scale C and D) able to ambulate 10 metres with the use of a walking stick or frame...
November 6, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29108272/up-regulated-expression-of-oxytocin-mrna-in-peripheral-blood-lymphocytes-from-first-episode-schizophrenia-patients
#14
Xiudeng Yang, Yamei Tang, Qinling Wei, Bing Lang, Huai Tao, Xianghui Zhang, Yong Liu, Aiguo Tang
Schizophrenia (SZ) is a severe neuropsychiatric disorder with significant social cognition impairment. Increasing evidence has suggested that neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) are important mediators of complex social cognition and behavior associates with SZ. In the present study, forty-three first-episode schizophrenia (FES) patients and forty-seven healthy controls (HC) were included. The peripheral mRNA expression of OXT, OXT receptor (OXTR), AVP, AVP 1a receptor (AVPR1a) and CD38 was determined by real-time quantitative polymerase chain reaction (RT-qPCR)...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29102346/is-functional-electrical-stimulation-an-alternative-for-orthotics-in-patients-with-cerebral-palsy-a-literature-review
#15
REVIEW
Sam Khamis, Talia Herman, Sima Krimus, Barry Danino
BACKGROUND: Functional electrical stimulation (FES) is a well-known intervention used during walking to improve walking abilities and correct gait deviations by facilitating the proper muscle group at the appropriate timing in the gait cycle. Our aim was to study the types of surface FES currently used in a cerebral palsy (CP) population and examine the evidence of its ability to improve gait deviations, functional ability and therapeutic effects. METHODS: A computerized database search was conducted from inception until 6/2016...
October 14, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29100858/the-incidence-and-characteristics-of-stroke-in-urban-dwelling-iranian-women
#16
Amin Amiri, Moira K Kapral, Amanda G Thrift, Luciano A Sposato, Hamidreza Saber, Reza Behrouz, Mahdiyeh Erfanian, Mohammad Taghi Farzadfard, Naghmeh Mokhber, Mahmoud Reza Azarpazhooh
BACKGROUND: Population-based data regarding stroke among women are scarce in developing countries. This study was designed to determine whether sex differences exist in stroke incidence, mortality, and recurrence. METHODS: The Mashhad Stroke Incidence Study is a population-based cohort study in Iran. For a period of 1 year, all patients with stroke in 3 geographical regions in Mashhad were recruited and then followed up for 5 years. Age- and sex-specific crude incidence rates were standardized to the World Health Organization New World Population...
October 31, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29100510/antimicrobial-effects-of-zero-valent-iron-nanoparticles-on-gram-positive-bacillus-strains-and-gram-negative-escherichia-coli-strains
#17
Yi-Huang Hsueh, Ping-Han Tsai, Kuen-Song Lin, Wan-Ju Ke, Chao-Lung Chiang
BACKGROUND: Zero-valent iron nanoparticles (ZVI NPs) have been used extensively for the remediation of contaminated soil and groundwater. Owing to their large active surface area, they serve as strong and effective reductants. However, the ecotoxicity and bioavailability of ZVI NPs in diverse ecological media have not been evaluated in detail and most studies have focused on non-nano ZVI or Fe(0). In addition, the antimicrobial properties of ZVI NPs have rarely been investigated, and the underlying mechanism of their toxicity remains unknown...
November 3, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29099387/distributed-stimulation-increases-force-elicited-with-functional-electrical-stimulation
#18
Alie J Buckmire, Danielle R Lockwood, Cynthia J Doane, Andrew J Fuglevand
The maximum muscle forces that can be evoked using functional electrical stimulation (FES) are relatively modest. The reason for this weakness is not fully understood but could be partly related to the widespread distribution of motor nerve branches within muscle. As such, a single stimulating electrode (as is conventionally used) may be incapable of activating the entire array of motor axons supplying a muscle. Therefore, the objective of this study was to determine whether stimulating a muscle with more than one source of current could boost force above that achievable with a single source...
November 3, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29098645/neurocognitive-graphs-of-first-episode-schizophrenia-and-major-depression-based-on-cognitive-features
#19
Sugai Liang, Roberto Vega, Xiangzhen Kong, Wei Deng, Qiang Wang, Xiaohong Ma, Mingli Li, Xun Hu, Andrew J Greenshaw, Russell Greiner, Tao Li
Neurocognitive deficits are frequently observed in patients with schizophrenia and major depressive disorder (MDD). The relations between cognitive features may be represented by neurocognitive graphs based on cognitive features, modeled as Gaussian Markov random fields. However, it is unclear whether it is possible to differentiate between phenotypic patterns associated with the differential diagnosis of schizophrenia and depression using this neurocognitive graph approach. In this study, we enrolled 215 first-episode patients with schizophrenia (FES), 125 with MDD, and 237 demographically-matched healthy controls (HCs)...
November 2, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29097257/a-randomized-13-week-study-assessing-the-efficacy-and-metabolic-effects-of-paliperidone-palmitate-injection-and-olanzapine-in-first-episode-schizophrenia-patients
#20
Manli Huang, Liang Yu, Fen Pan, Shaojia Lu, Shaohua Hu, Jianbo Hu, Jinkai Chen, Pingbo Jin, Hongli Qi, Yi Xu
BACKGROUND: This study was conducted to evaluate the efficacy and metabolic effects of paliperidone palmitate (PP) injections against oral olanzapine in first-episode schizophrenia (FES) patients. METHODS: Eligible patients were randomized to receive PP or olanzapine. Efficacy assessments and weight-related parameters were assessed at baseline, weeks 1, 5, 9, and endpoint or at early withdrawal. Lipid, glucose, insulin and prolactin were evaluated at baseline and endpoint or at early withdrawal...
October 31, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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