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https://www.readbyqxmd.com/read/28550345/bacillus-zanthoxyli-sp-nov-a-novel-nematicidal-bacterium-isolated-from-chinese-red-pepper-zanthoxylum-bungeanum-maxim-leaves-in-china
#1
Ma Li, Cao Yong Hong, Wang Xiao Yan, Zheng Shuai Chao, Yang Cheng Gang, Duo Jin Ling, Zhou Xing Kui, Xi Jia Qin, Zhu Ming Liang, Mo Ming He
A novel strain, 1433(T), was isolated from leaves of Chinese red pepper (Huajiao, Zanthoxylum bungeanum Maxim) collected from Gansu province in northwestern China, and was characterised by a polyphasic approach. Cells of strain 1433(T) were observed to be Gram-stain positive, aerobic, asporogenous, rod shaped, motile and to have peritrichous flagella. The strain was observed to grow at a range of temperatures and pH, 4-45 °C (optimum 28-32 °C) and 6.0-10.0 (optimum pH 6.0-7.0), respectively. Growth was found to occur in the presence of 0-7% (w/v) NaCl [optimum 0-3% (w/v)]...
May 26, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28508565/menaquinone-4-enhances-osteogenic-potential-of-human-amniotic-fluid-mesenchymal-stem-cells-cultured-in-a-2d-and-3d-dynamic-culture-system
#2
Domitilla Mandatori, Letizia Penolazzi, Caterina Pipino, Pamela Di Tomo, Sara Di Silvestre, Natalia Di Pietro, Sara Trevisani, Marco Angelozzi, Mariangela Ucci, Roberta Piva, Assunta Pandolfi
Menaquinones, also known as Vitamin K2 family, regulate calcium homeostasis in a "bone-vascular cross talk" and recently received particular attention for their positive effect on bone formation. Since the correlation between menaquinones and bone metabolism to date is still unclear, the objective of our study was to investigate the possible role of menaquinone-4 (MK-4), an isoform of the menaquinones family, in the modulation of osteogenesis. For this reason we used a model of human Amniotic Fluid Mesenchymal Stem Cells (hAFMSCs) cultured both in two-dimensional (2D) and three-dimensional (3D, RCCS™bioreactor) in vitro culture systems...
May 16, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28500545/nocardia-tengchongensis-sp-nov-isolated-from-a-soil-sample
#3
Shuai Li, Hong Ming, Yan-Yan Duan, Jian-Rong Huang, Zhuo-Li Zhao, Ling-Yu Zhang, Wei-Li Ji, Xiao-Lin Meng, Wen-Jun Li, Guo-Xing Nie
The taxonomic status was determined of two actinomycetes, designated CFH S0057(T) and CFH S0065, that were isolated from soil samples collected from an extinct volcano in Tengchong county, Yunnan province, south-west China. Phylogenetic analysis based on 16S rRNA gene sequences showed that strains CFH S0057(T) and CFH S0065 belong to the genus Nocardia and formed a single clade within this genus. The two isolates were able to grow at 4-45 °C, pH 5.0-7.0 and with a NaCl tolerance up to 5.0% (w/v). The whole-cell hydrolysates were rich in meso-diaminopimelic acid, galactose, arabinose and fructose...
May 12, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28488064/rhodococcus-gannanensis-sp-nov-a-novel-endophytic-actinobacterium-isolated-from-root-of-sunflower-helianthus-annuus-l
#4
Jun Ma, Liguo Zhang, Guangjin Wang, Shuquan Zhang, Xiaofei Zhang, Yongbin Wang, Chuanqi Shi, Liang Si, Haibin Zhao, Fengqi Liu, Bixian Zhang, Xutang Huang
A novel Gram-positive, aerobic, non-motile strain, designated strain M1(T), was isolated from sunflower root (Helianthus annuus L.) and characterised using a polyphasic taxonomic approach. The morphological and chemotaxonomic properties of the isolate were typical of those of members of the genus Rhodococcus. Phylogenetic analyses based on 16S rRNA gene sequence showed that strain M1(T) belongs to the genus Rhodococcus and clustered with Rhodococcus canchipurensis MBRL 353(T) (99.1%, sequence similarity) and Rhodococcus pedocola UC12(T) (98...
May 9, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28464802/phosphate-binders-affect-vitamin-k-concentration-by-undesired-binding-an-in-vitro-study
#5
A Neradova, S P Schumacher, I Hubeek, P Lux, L J Schurgers, M G Vervloet
BACKGROUND: Vascular calcification is a major contributing factor to mortality in end stage renal disease (ESRD). Despite the efficacy of phosphate binders to improve hyperphosphatemia, data on vascular calcification are less clear. There seems to be a difference in attenuation or delay in progression between different binders. In this in vitro experiment we tested whether phosphate binders could limit bioavailability of vitamin K2 by undesired binding. Vitamin K-deficiency limits activation of the vascular tissue mineralization inhibitor matrix γ-carboxyglutamate (Gla) protein (MGP) thereby exacerbating vascular calcification...
May 2, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28455763/terrimonas-suqianensis-sp-nov-isolated-from-a-tetrabromobisphenol-a-contaminated-soil
#6
Qing Chen, Xiao-Xia Zang, Xing Hang, Jing Chen, Hong-Mei Wang, Shun-Peng Li, Jian-Dong Jiang, Kai Chen
Strain C3-5(T), a Gram-negative, asporogenous, rod-shaped bacterium, was isolated from a tetrabromobisphenol A contaminated soil. Growth was observed at 10-37 °C (optimum 30 °C) and at pH 5.5-9.5 (optimum pH 7.0). Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain C3-5(T) is a member of the genus Terrimonas and exhibits high sequence similarities with Terrimonas pekingensis QH(T) (99.0%) and Terrimonas rhizosphaerae CR94(T) (97.3%), and exhibits low (<97%) sequence similarities with other known Terrimonas species...
April 28, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28445967/lactobacillus-casei-zhang-and-vitamin-k2-prevent-intestinal-tumorigenesis-in-mice-via-adiponectin-elevated-different-signaling-pathways
#7
Yong Zhang, Chen Ma, Jie Zhao, Haiyan Xu, Qiangchuan Hou, Heping Zhang
The incidence of colon cancer has increased considerably and the intestinal microbiota participate in the development of colon cancer. We showed that the L. casei Zhang or vitamin K2 (Menaquinone-7) intervention significantly alleviated intestinal tumor burden in mice. This was associated with increased serum adiponectin levels in both treatments. But osteocalcin level was only increased by L. casei Zhang. Furthermore, the anti-carcinogenic actions of L. casei Zhang were mediated by hepatic Chloride channel-3(CLCN3)/Nuclear Factor Kappa B(NF-κB) and intestinal Claudin15/Chloride intracellular channel 4(CLIC4)/Transforming Growth Factor Beta(TGF-β) signaling, while the vitamin K2 effect involved a hepatic Vitamin D Receptor(VDR)-phosphorylated AMPK signaling pathway...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28439678/aquimarina-seongsanensis-sp-nov-isolated-from-sea-water
#8
Yoojin Oh, Bong-Geun Choi, Joon Yong Kim, Seong Woon Roh, Sung-Jae Lee
An orange, rod-shaped, gliding bacterium, designated strain CBA3208(T), was isolated from sea water of Jeju Island, Republic of Korea. Cells were observed to be Gram-stain negative, strictly aerobic, catalase positive and oxidase negative and to hydrolyse starch, gelatin, and Tweens 40 and 80. The major fatty acids were identified as iso-C15:0, iso-C17:0 3-OH, and iso-C15:1 G. The only isoprenoid quinone was found to be menaquinone-6 (MK-6) and the major polar lipids were identified as phosphatidylethanolamine, two aminolipids and four unidentified polar lipids...
April 24, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28429167/corynebacterium-defluvii-sp-nov-isolated-from-sewage
#9
Qiu-Li Yu, Zheng-Fei Yan, Xin He, Feng-Hua Tian, Chuan-Wen Jia, Chang-Tian Li
A Gram-positive, aerobic, non-motile, rod-shapeds, cata-lase-positive, and oxidase-negative strain, designated Y49(T), was isolated from sewage collected from Jilin Agricultural University, China. It grew at 20-40°C (optimum at 30°C), at pH 6.0-8.0 (optimum at 7.0) and at 0-1.0% sodium chloride (optimum at 0%). The major isoprenoid quinone was menaquinone-8 (MK-8) and the polar lipids were diphosphatidylglycerol, phosphatidylglycerol, phosphatidylmethylethanolamine, four unidentified lipids, and two unidentified aminolipids...
April 20, 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28417190/larkinella-harenae-sp-nov-isolated-from-korean-beach-soil
#10
Su-Jin Park, Jae-Jin Lee, Seung-Yeol Lee, Dae Sung Lee, Myung Kyum Kim, Leonid N Ten, Hee-Young Jung
A Gram-negative, short rod-shaped, gliding motile, and pale pink-pigmented bacterial strain, designated 15J9-9(T), was isolated from the soil of Iho Tewoo Beach, Jeju Island, Korea, and characterized taxonomically using a polyphasic approach. Comparative 16S rRNA gene sequence analysis showed that strain 15J9-9(T) belonged to the family Cytophagaceae and was related to Larkinella bovis M2T2B15(T) (96.5% similarity), Larkinella arboricola Z0532(T) (95.3% similarity), and Larkinella insperata LMG 22510(T) (95...
April 17, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28405861/pk-a-of-ubiquinone-menaquinone-phylloquinone-plastoquinone-and-rhodoquinone-in-aqueous-solution
#11
Ryo Hasegawa, Keisuke Saito, Tomohiro Takaoka, Hiroshi Ishikita
Quinones can accept two electrons and two protons, and are involved in electron transfer and proton transfer reactions in photosynthetic reaction centers. To date, the pK a of these quinones in aqueous solution have not been reported. We calculated the pK a of the initial protonation (Q(·-) to QH(·)) and the second protonation (QH(-) to QH2) of 1,4-quinones using a quantum chemical approach. The calculated energy differences of the protonation reactions Q(·-) to QH(·) and QH(-) to QH2 in the aqueous phase for nine 1,4-quinones were highly correlated with the experimentally measured pK a(Q(·-)/QH(·)) and pK a(QH(-)/QH2), respectively...
April 12, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28403946/vitamin-k-and-osteoporosis-myth-or-reality
#12
REVIEW
Andrea Palermo, Dario Tuccinardi, Luca D'Onofrio, Mikiko Watanabe, Daria Maggi, Anna Rita Maurizi, Valentina Greto, Raffaella Buzzetti, Nicola Napoli, Paolo Pozzilli, Silvia Manfrini
Vitamin K is a liposoluble vitamin. The predominant dietary form, phylloquinone or vitamin K1, is found in plants and green vegetables; whereas menaquinone, or vitamin K2, is endogenously synthesized by intestinal bacteria and includes several subtypes that differ in side chain length. Aside from its established role in blood clotting, several studies now support a critical function of vitamin K in improving bone health. Vitamin K is in fact required for osteocalcin carboxylation that in turn regulates bone mineral accretion; it seems to promote the transition of osteoblasts to osteocytes and also limits the process of osteoclastogenesis...
May 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28396391/enhanced-respiration-prevents-drug-tolerance-and-drug-resistance-in-mycobacterium-tuberculosis
#13
Catherine Vilchèze, Travis Hartman, Brian Weinrick, Paras Jain, Torin R Weisbrod, Lawrence W Leung, Joel S Freundlich, William R Jacobs
Persistence, manifested as drug tolerance, represents a significant obstacle to global tuberculosis control. The bactericidal drugs isoniazid and rifampicin kill greater than 99% of exponentially growing Mycobacterium tuberculosis (Mtb) cells, but the remaining cells are persisters, cells with decreased metabolic rate, refractory to killing by these drugs, and able to generate drug-resistant mutants. We discovered that the combination of cysteine or other small thiols with either isoniazid or rifampicin prevents the formation of drug-tolerant and drug-resistant cells in Mtb cultures...
April 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28326075/advantages-of-the-silkworm-as-an-animal-model-for-developing-novel-antimicrobial-agents
#14
REVIEW
Suresh Panthee, Atmika Paudel, Hiroshi Hamamoto, Kazuhisa Sekimizu
The demand for novel antibiotics to combat the global spread of multi drug-resistant pathogens continues to grow. Pathogenic bacteria and fungi that cause fatal human infections can also kill silkworms and the infected silkworms can be cured by the same antibiotics used to treat infections in the clinic. As an invertebrate model, silkworm model is characterized by its convenience, low cost, no ethical issues. The presence of conserved immune response and similar pharmacokinetics compared to mammals make silkworm infection model suitable to examine the therapeutic effectiveness of antimicrobial agents...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28325762/a-genetic-screen-reveals-that-synthesis-of-1-4-dihydroxy-2-naphthoate-dhna-but-not-full-length-menaquinone-is-required-for-listeria-monocytogenes-cytosolic-survival
#15
Grischa Y Chen, Courtney E McDougal, Marc A D'Antonio, Jonathan L Portman, John-Demian Sauer
Through unknown mechanisms, the host cytosol restricts bacterial colonization; therefore, only professional cytosolic pathogens are adapted to colonize this host environment. Listeria monocytogenes is a Gram-positive intracellular pathogen that is highly adapted to colonize the cytosol of both phagocytic and nonphagocytic cells. To identify L. monocytogenes determinants of cytosolic survival, we designed and executed a novel screen to isolate L. monocytogenes mutants with cytosolic survival defects. Multiple mutants identified in the screen were defective for synthesis of menaquinone (MK), an essential molecule in the electron transport chain...
March 21, 2017: MBio
https://www.readbyqxmd.com/read/28304162/rational-design-synthesis-and-biological-evaluation-of-heterocyclic-quinolones-targeting-the-respiratory-chain-of-mycobacterium-tuberculosis
#16
W David Hong, Peter D Gibbons, Suet C Leung, Richard Amewu, Paul A Stocks, Andrew Stachulski, Pedro Horta, Maria L S Cristiano, Alison E Shone, Darren Moss, Alison Ardrey, Raman Sharma, Ashley J Warman, Paul T P Bedingfield, Nicholas E Fisher, Ghaith Aljayyoussi, Sally Mead, Maxine Caws, Neil G Berry, Stephen A Ward, Giancarlo A Biagini, Paul M O'Neill, Gemma L Nixon
A high-throughput screen (HTS) was undertaken against the respiratory chain dehydrogenase component, NADH:menaquinone oxidoreductase (Ndh) of Mycobacterium tuberculosis (Mtb). The 11000 compounds were selected for the HTS based on the known phenothiazine Ndh inhibitors, trifluoperazine and thioridazine. Combined HTS (11000 compounds) and in-house screening of a limited number of quinolones (50 compounds) identified ∼100 hits and four distinct chemotypes, the most promising of which contained the quinolone core...
May 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28303399/deinococcus-planocerae-sp-nov-isolated-from-a-marine-flatworm
#17
Huina Lin, Yong Wang, Jiaomei Huang, Qiliang Lai, Ying Xu
A Gram-positive, non-motile and coccoid strain, designated XY-FW106(T), was isolated from a marine flatworm identified to be Planocera sp. The 16S rRNA gene sequence of this pink organism was consistent with membership of the genus Deinococcus, with high sequence similarity to Deinococcus aetherius ST0316(T) (94.7%). The optimum growth temperature range of the strain XY-FW106(T) was found to be 25-30 °C and optimum growth occurs at pH 7.2-7.4 without NaCl. The strain XY-FW106(T) was found to contain unidentified glycolipids, unidentified phosphoglycolipids, unidentified phospholipids and unidentified lipids, which differed from those of closely related species...
March 16, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28289918/geodermatophilus-daqingensis-sp-nov-isolated-from-petroleum-contaminated-soil
#18
Yang Wang, Liguo Zhang, Xiaofei Zhang, Jinying Huang, Yu Zhao, Yuanling Zhao, Jianxin Liu, Cui Huang, Jing Wang, Yingying Hu, Guoling Ren, Xiuhong Xu
A novel Gram-positive actinobacterium, designated WT-2-1(T), was isolated from a sample of petroleum-contaminated soil collected in Daqing, Heilongjiang province, China and characterised using a polyphasic taxonomic approach. The optimal growth for strain WT-2-1(T) was found to be at 25-35 °C and at pH 6.0-9.0 and with 0-4% (w/v) NaCl, forming blackish green-coloured colonies. Chemotaxonomic and molecular characteristics of the isolate match those described for members of the genus Geodermatophilus. The peptidoglycan was found to contain meso-diaminopimelic acid; galactose, glucose and xylose were detected as diagnostic sugars...
March 13, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28258406/biotransformation-of-menadione-to-its-prenylated-derivative-mk-3-using-recombinant-pichia-pastoris
#19
Zhemin Li, Genhai Zhao, Hui Liu, Yugang Guo, Hefang Wu, Xiaowen Sun, Xihua Wu, Zhiming Zheng
Prenylated quinones, especially menaquinones, have significant physiological activities, but are arduous to synthesize efficiently. Due to the relaxed aromatic substrate specificity and prenylation regiospecificity at the ortho- site of the phenolic hydroxyl group, the aromatic prenyltransferase NovQ from Streptomyces may be useful in menaquinone synthesis from menadione. In this study, NovQ was overexpressed in Pichia pastoris. After fermentation optimization, NovQ production increased by 1617%. Then the different effects of metal ions, detergents and pH on the activity of purified NovQ were investigated to optimize the prenylation reaction...
March 3, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28258367/enhancing-menaquinone-7-production-by-bacillus-natto-r127-through-the-nutritional-factors-and-surfactant
#20
Xue-Chao Hu, Wei-Ming Liu, Miao-Miao Luo, Lu-Jing Ren, Xiao-Jun Ji, He Huang
Bacillus natto is commonly used in industrial production of menaquinone-7, an important vitamin which plays a crucial role for blood clotting and may contribute to prevention of cardiovascular disease and osteoporosis. This study determined the optimal combination of key nutrients and established an effective use of surfactant in a coupling medium to enhance the yield of extracellular MK-7. MK-7 yield of 31.18 mg/L was achieved under optimal conditions containing 53.6 g/L glycerol, 100 g/L soy peptone, and 10 g/L K2HPO4...
March 3, 2017: Applied Biochemistry and Biotechnology
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