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https://www.readbyqxmd.com/read/28339264/anomalous-transport-in-the-superfluid-fluctuation-regime
#1
Shun Uchino, Masahito Ueda
Motivated by a recent experiment in ultracold atoms [S. Krinner et al., Proc. Natl. Acad. Sci. U.S.A. 113, 8144 (2016)PNASA60027-842410.1073/pnas.1601812113], we analyze transport of attractively interacting fermions through a one-dimensional wire near the superfluid transition. We show that in a ballistic regime where the conductance is quantized in the absence of interaction, the conductance is renormalized by superfluid fluctuations in reservoirs. In particular, the particle conductance is strongly enhanced, and the conductance plateau is blurred by emergent bosonic pair transport...
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28338971/progressive-silencing-of-the-zinc-transporter-zip8-slc39a8-in-chronic-cadmium-exposed-lung-epithelial-cells
#2
Yangmin Gao, Yanming Xu, Dandan Wu, Feiyuan Yu, Lei Yang, Yue Yao, Zhanling Liang, Andy T Y Lau
Cadmium (Cd), a non-essential metal, stealthily enters the cells by utilizing the essential metal importing pathways. The zinc transporters Zip8, Zip14, and divalent metal transporter 1 (Dmt1) are now emerging as several important metal transporters involved in cellular Cd incorporation and their expressions have been shown to be down-regulated in several Cd-resistant (CdR) cell lines, however, the involvement of these transporters during the development of Cd-resistance in lung cells is unclear. In this study, we therefore check the expression of these metal transporters in our previously established rat lung epithelial cells (LECs) and show that the level of Zip8 is progressively silenced when LECs are adapted to increasing concentrations of CdCl2 (from 1 to 20 μM)...
March 18, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28336296/serotonin-and-dopamine-transporter-pet-changes-in-the-premotor-phase-of-lrrk2-parkinsonism-cross-sectional-studies
#3
Daryl J Wile, Pankaj A Agarwal, Michael Schulzer, Edwin Mak, Katherine Dinelle, Elham Shahinfard, Nasim Vafai, Kazuko Hasegawa, Jing Zhang, Jessamyn McKenzie, Nicole Neilson, Audrey Strongosky, Ryan J Uitti, Mark Guttman, Cyrus P Zabetian, Yu-Shin Ding, Mike Adam, Jan Aasly, Zbigniew K Wszolek, Matthew Farrer, Vesna Sossi, A Jon Stoessl
BACKGROUND: People with Parkinson's disease can show premotor neurochemical changes in the dopaminergic and non-dopaminergic systems. Using PET, we assessed whether dopaminergic and serotonin transporter changes are similar in LRRK2 mutation carriers with Parkinson's disease and individuals with sporadic Parkinson's disease, and whether LRRK2 mutation carriers without motor symptoms show PET changes. METHODS: We did two cross-sectional PET studies at the Pacific Parkinson's Research Centre in Vancouver, BC, Canada...
March 20, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28336019/endotracheal-cuff-pressure-changes-during-helicopter-transport-a-systematic-review
#4
Ashleigh J Delorenzo, Matthew Shepherd, Paul A Jennings
OBJECTIVE: Cuff pressures are important in ventilated patients undergoing helicopter transport. An altitude-related increase in endotracheal tube (ETT) intracuff pressure has been shown in simulated hypobaric environments, model tracheas, and animal studies and may not accurately reflect in vivo pressures. The aim of this study was to determine if ETT intracuff pressure increases above the critical perfusion pressure of the trachea in ventilated patients during helicopter transport. METHODS: Ovid Medline, CINAHL, Embase, Scopus, and the Cochrane Library were searched from their commencement to January 29, 2016...
March 2017: Air Medical Journal
https://www.readbyqxmd.com/read/28336017/weather-webcam-system-for-the-safety-of-helicopter-emergency-medical-services-in-miyazaki-japan
#5
Katsuhiro Kanemaru, Robert Katzer, Syu Hanato, Koji Nakamura, Hiroshi Matsuoka, Hidenobu Ochiai
OBJECTIVE: In Japan, the helicopter emergency medical services (HEMS) system was initiated in 2001 and introduced to Miyazaki Prefecture in 2012. Mountainous areas occupy 88% of Miyazaki's land area, and HEMS flights can be subject to the effects of weather. Therefore, ensuring safety in changing weather conditions is a necessity for HEMS. METHODS: The weather webcam system (WWS) was established to observe the meteorological conditions in 29 locations. Assessments of the probability of a flight based on conventional data including a weather chart provided by the Japan Meteorological Agency and meteorological reports provided by the Miyazaki Airport were compared with the assessment based on the combination of the information obtained from the WWS and the conventional data...
March 2017: Air Medical Journal
https://www.readbyqxmd.com/read/28333448/role-of-oxygen-functionalities-in-graphene-oxide-architectural-laminates-goal-sub-nanometer-spacing-and-water-transport
#6
Carlo Alberto Amadei, Andrea Montessori, Julian P Kadow, Sauro Succi, Chad David Vecitis
Active research in nanotechnology contemplates the use of nanomaterials for environmental engineering applications. However, a primary challenge is understanding the effects of nanomaterial properties on industrial device performance and translating unique nanoscale properties to the macroscale. One emerging example is graphene oxide (GO) membranes for separation processes. Thus, here we investigate how individual GO properties, in particular the GO chemistry, can impact GO membrane characteristics and water permeability...
March 23, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28331313/involvement-of-pink1-parkin-mediated-mitophagy-in-zno-nanoparticle-induced-toxicity-in-bv-2-cells
#7
Limin Wei, Jianfeng Wang, Aijie Chen, Jia Liu, Xiaoli Feng, Longquan Shao
With the increasing application of zinc oxide nanoparticles (ZnO NPs) in biological materials, the neurotoxicity caused by these particles has raised serious concerns. However, the underlying molecular mechanisms of the toxic effect of ZnO NPs on brain cells remain unclear. Mitochondrial damage has been reported to be a factor in the toxicity of ZnO NPs. PINK1/parkin-mediated mitophagy is a newly emerging additional function of autophagy that selectively degrades impaired mitochondria. Here, a PINK1 gene knockdown BV-2 cell model was established to determine whether PINK1/parkin-mediated mitophagy was involved in ZnO NP-induced toxicity in BV-2 cells...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28331092/monkeypox-virus-host-factor-screen-in-haploid-cells-identifies-essential-role-of-garp-complex-in-extracellular-virus-formation
#8
Susan Realegeno, Andreas S Puschnik, Amrita Kumar, Cynthia Goldsmith, Jillybeth Burgado, Suryaprakash Sambhara, Victoria A Olson, Darin Carroll, Inger Damon, Tetsuya Hirata, Taroh Kinoshita, Jan E Carette, Panayampalli Subbian Satheshkumar
Monkeypox virus (MPXV) is a human pathogen that is a member of the Orthopoxvirus genus, which includes Vaccinia virus and Variola virus (the causative agent of smallpox). Human monkeypox is considered an emerging zoonotic infectious disease. To identify host factors required for MPXV infection, we performed a genome-wide insertional mutagenesis screen in human haploid cells. The screen revealed several candidate genes, including those involved in Golgi trafficking, glycosaminoglycan biosynthesis and glycosylphosphatidylinositol (GPI) - anchor biosynthesis...
March 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28330327/role-of-gnb3-net-kcnj11-tcf7l2-and-grl-genes-single-nucleotide-polymorphism-in-the-risk-prediction-of-type-2-diabetes-mellitus
#9
REVIEW
Saliha Rizvi, Syed Tasleem Raza, Qamar Rahman, Farzana Mahdi
Type 2 diabetes (T2DM) is a polygenic metabolic disorder characterized by hyperglycemia occurring as a result of impaired insulin secretion or insulin resistance. Various environmental and genetic factors interact and increase the risk of T2DM and its complications. Among the various genetic factors associated with T2DM, single nucleotide polymorphism in different candidate genes have been studied intensively and the resulting genetic variants have been found to have either positive or negative association with T2DM thereby increasing or decreasing the risk of T2DM, respectively...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28327439/an-in-silico-functional-annotation-and-screening-of-potential-drug-targets-derived-from-leishmania-spp-hypothetical-proteins-identified-by-immunoproteomics
#10
Miguel A Chávez-Fumagalli, Mônica S Schneider, Daniela P Lage, Ricardo A Machado-de-Ávila, Eduardo A F Coelho
Leishmaniasis is a parasitic disease caused by the protozoan of the Leishmania genus. While no human vaccine is available, drugs such as pentavalent antimonials, pentamidine and amphotericin B are used for treat the patients. However, the high toxicity of these pharmaceutics, the emergence of parasite resistance and/or their high cost have showed to the urgent need of identify new targets to be employed in the improvement of the treatment against leishmaniasis. In a recent immunoproteomics approach performed in the Leishmania infantum species, 104 antigenic proteins were recognized by antibodies in sera of visceral leishmaniasis (VL) dogs...
March 19, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28326089/dynamic-regulation-of-auxin-response-during-rice-development-revealed-by-newly-established-hormone-biosensor-markers
#11
Jing Yang, Zheng Yuan, Qingcai Meng, Guoqiang Huang, Christophe Périn, Charlotte Bureau, Anne-Cécile Meunier, Mathieu Ingouff, Malcolm J Bennett, Wanqi Liang, Dabing Zhang
The hormone auxin is critical for many plant developmental processes. Unlike the model eudicot plant Arabidopsis (Arabidopsis thaliana), auxin distribution and signaling in rice tissues has not been systematically investigated due to the absence of suitable auxin response reporters. In this study we observed the conservation of auxin signaling components between Arabidopsis and model monocot crop rice (Oryza sativa), and generated complementary types of auxin biosensor constructs, one derived from the Aux/IAA-based biosensor DII-VENUS but constitutively driven by maize ubiquitin-1 promoter, and the other termed DR5-VENUS in which a synthetic auxin-responsive promoter (DR5rev ) was used to drive expression of the yellow fluorescent protein (YFP)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28325207/using-a-systematic-framework-of-interventions-to-improve-early-discharges
#12
Hemali Patel, Sasha Morduchowicz, Michelle Mourad
BACKGROUND: Late-afternoon hospital discharges can lead to admission bottlenecks and negatively affect the flow of patients needing hospital admission. Delays in discharge are a prevalent health care problem and have been linked to increased length of stay, lower patient satisfaction scores, and adverse outcomes. As a result, hospitals are placing a renewed emphasis on early discharge as a way to reduce admission delays and achieve optimal patient flow. This study shows that the Model for Improvement (MFI) is an effective approach for complex improvement efforts...
April 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28324238/kinetics-of-expression-of-genes-involved-in-glucose-metabolism-after-the-last-meal-in-overfed-mule-ducks
#13
Tavernier Annabelle, Ricaud Karine, Bernadet Marie-Dominique, Davail Stéphane, Gontier Karine
In waterfowls, overfeeding leads to a hepatic steatosis, also called "foie gras." We decided to investigate the role of glucose metabolism in steatosis emergence. For this, we measured the expression of genes during the 12 h following the last meal of the overfeeding period. As expected, it showed that the expression of glucose transporter is more precocious in jejunal mucosa, especially for SGLT1, known to be the major transporter at the apical surface. In the liver, GLUT2 and HK1 are upregulated at the same time and seem to work together to import glucose...
March 21, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28323639/the-effect-of-boundary-slippage-and-nonlinear-rheological-response-on-flow-of-nanoconfined-water
#14
Amandeep Sekhon, V J Ajith, Shivprasad Vitthal Patil
The flow of water confined to nanometer-sized pores is central to a wide range of subjects from biology to nanofluidic devices. Despite its importance, a clear picture about nanoscale fluid dynamics is yet to emerge. Here we measured dissipation in less than 20 nm thick water films and it was found to decrease for both wetting and non-wetting confining surfaces. The fitting of Carreau-Yasuda model of shear thinning to our measurements implies that flow is non-Newtonian and for wetting surfaces the no-slip boundary condition is valid...
March 21, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28322438/risk-factors-for-malnutrition-among-older-adults-in-the-emergency-department-a-multicenter-study
#15
Collin E Burks, Christopher W Jones, Valerie A Braz, Robert A Swor, Natalie L Richmond, Kay S Hwang, Allison G Hollowell, Mark A Weaver, Timothy F Platts-Mills
BACKGROUND: Among older adults, malnutrition is common, often missed by healthcare providers, and influences recovery from illness or injury. OBJECTIVE: To identify modifiable risk factors associated with malnutrition in older patients. DESIGN: Prospective cross-sectional multicenter study. SETTING: 3 EDs in the South, Northeast, and Midwest. PARTICIPANTS: Non-critically ill, English-speaking adults aged ≥65 years...
March 21, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28320621/global-reverse-supply-chain-design-for-solid-waste-recycling-under-uncertainties-and-carbon-emission-constraint
#16
Zhitao Xu, Adel Elomri, Shaligram Pokharel, Qin Zhang, X G Ming, Wenjie Liu
The emergence of concerns over environmental protection, resource conservation as well as the development of logistics operations and manufacturing technology has led several countries to implement formal collection and recycling systems of solid waste. Such recycling system has the benefits of reducing environmental pollution, boosting the economy by creating new jobs, and generating income from trading the recyclable materials. This leads to the formation of a global reverse supply chain (GRSC) of solid waste...
March 17, 2017: Waste Management
https://www.readbyqxmd.com/read/28320228/living-as-a-person-using-a-lower-limb-prosthesis-in-nepal
#17
Anna Järnhammer, Beatrice Andersson, Prakash Raj Wagle, Lina Magnusson
PURPOSE: The purpose of this study is to explore experiences of persons in Nepal using lower-limb prostheses, in relation to specific articles in the Convention on the Rights of Persons with Disabilities that consider mobility, education, health, rehabilitation, and work and employment. METHOD: Qualitative interviews were conducted with 16 persons using lower limb prostheses. Content analysis was applied to the data. RESULTS: Six themes emerged: The lower-limb prosthesis is essential for mobility and daily life; Limited mobility in challenging terrain and request for reduced pain when using prosthesis; Difficulties in finding and sustaining employment emphasized the importance of vocational training; Appreciation of comprehensive rehabilitation together with other persons with amputations, but covering related costs is a struggle; Satisfied with health care, but concerned that it creates debt and dependence upon others; and finally, Limited ability creates negative self-image and varied attitudes in other people...
March 21, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28318299/lithocholic-acid-a-new-emergent-protector-of-intestinal-calcium-absorption-under-oxidant-conditions
#18
Ana M Marchionatti, Adriana Pérez, María A Rivoira, Valeria A Rodríguez, Nori G Tolosa de Talamoni
LCA and 1,25(OH)2D3 are vitamin D receptor ligands with different binding affinity. The secosteroid stimulates intestinal Ca(2+) absorption. Whether LCA alters this process remains unknown. The aim of our work was to determine the effect of LCA on intestinal Ca(2+) absorption in the absence or presence of NaDOC, bile acid that inhibits the cation transport. The data show that LCA by itself did not alter intestinal Ca(2+) absorption, but prevented the inhibitory effect of NaDOC. The concomitant administration of LCA avoided the reduction of intestinal alkaline phosphatase activity caused by NaDOC...
March 20, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28315258/mechanisms-of-iron-sensing-and-regulation-in-the-yeast-saccharomyces-cerevisiae
#19
REVIEW
María Teresa Martínez-Pastor, Ana Perea-García, Sergi Puig
Iron is a redox active element that functions as an essential cofactor in multiple metabolic pathways, including respiration, DNA synthesis and translation. While indispensable for eukaryotic life, excess iron can lead to oxidative damage of macromolecules. Therefore, living organisms have developed sophisticated strategies to optimally regulate iron acquisition, storage and utilization in response to fluctuations in environmental iron bioavailability. In the yeast Saccharomyces cerevisiae, transcription factors Aft1/Aft2 and Yap5 regulate iron metabolism in response to low and high iron levels, respectively...
April 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28314154/streamlined-approach-to-mapping-the-magnetic-induction-of-skyrmionic-materials
#20
Jordan J Chess, Sergio A Montoya, Tyler R Harvey, Colin Ophus, Simon Couture, Vitaliy Lomakin, Eric E Fullerton, Benjamin J McMorran
Recently, Lorentz transmission electron microscopy (LTEM) has helped researchers advance the emerging field of magnetic skyrmions. These magnetic quasi-particles, composed of topologically non-trivial magnetization textures, have a large potential for application as information carriers in low-power memory and logic devices. LTEM is one of a very few techniques for direct, real-space imaging of magnetic features at the nanoscale. For Fresnel-contrast LTEM, the transport of intensity equation (TIE) is the tool of choice for quantitative reconstruction of the local magnetic induction through the sample thickness...
February 28, 2017: Ultramicroscopy
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