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https://www.readbyqxmd.com/read/29222959/development-of-depth-encoding-small-animal-pet-detectors-by-using-dual-ended-readout-of-pixelated-scintillator-arrays-with-sipms
#1
Zhonghua Kuang, Ziru Sang, Xiaohui Wang, Xin Fu, Ning Ren, Xianming Zhang, Yunfei Zheng, Qian Yang, Zhanli Hu, Junwei Du, Dong Liang, Xin Liu, Hairong Zheng, Yongfeng Yang
PURPOSE: The performance of current small animal PET scanners is mainly limited by the detector performance and depth encoding detectors are required to develop PET scanner to simultaneously achieve high spatial resolution and high sensitivity. Among all depth encoding PET detector approaches, dual-ended readout detector has the advantage to achieve the highest depth of interaction (DOI) resolution and spatial resolution. Silicon photomultiplier (SiPM) is believed to be the photodetector of the future for PET detector due to its excellent properties as compared to the traditional photodetectors such as photomultiplier tube (PMT) and avalanche photodiode (APD)...
December 9, 2017: Medical Physics
https://www.readbyqxmd.com/read/29221127/long-noncoding-rnas-expression-profile-and-functional-networks-in-rheumatoid-arthritis
#2
Donghua Xu, Ye Jiang, Lu Yang, Xixing Hou, Jihong Wang, Weijun Gu, Xiaodong Wang, Lanyu Liu, Juan Zhang, Hongying Lu
The modifying effects of long noncoding RNAs (lncRNAs) in rheumatoid arthritis (RA) recently have drawn much attention; however, the underlying mechanisms remain largely unknown. Herein, we aim to investigate the expression profile of lncRNAs in RA and identify promising targets for RA diagnosis and treatment. Microarray screening and real-time PCR of lncRNAs were performed by use of serum samples from 3 RA patients and 3 healthy controls. Significantly differentially expressed lncRNAs were verified in serum samples from 43 RA patients and 40 healthy controls by real-time PCR...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29219638/clinical-efficacy-radiographic-and-safety-results-of-golimumab-monotherapy-in-japanese-patients-with-active-rheumatoid-arthritis-despite-prior-therapy-with-disease-modifying-antirheumatic-drugs-final-results-of-the-go-mono-trial-through-week-120
#3
Tsutomu Takeuchi, Masayoshi Harigai, Yoshiya Tanaka, Hisashi Yamanaka, Naoki Ishiguro, Kazuhiko Yamamoto, Nobuyuki Miyasaka, Takao Koike, Yoshifumi Ukyo, Yutaka Ishii, Toru Yoshinari, Daniel Baker
OBJECTIVE: Evaluate the safety and efficacy of golimumab through week 120 in Japanese patients with active rheumatoid arthritis (RA) previously treated with DMARDs. METHODS: Japanese patients with active RA despite prior DMARDs were randomized to placebo (Group 1, n = 105), golimumab 50 mg (Group 2, n = 101), or golimumab 100 mg (Group 3, n = 102). At week 16, Group 1 patients crossed over to golimumab 50mg; after week 52, a one-time golimumab dose reduction from 100 to 50 mg was permitted...
December 8, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/29211949/fluoride-uptake-profiles-of-selected-european-toothpastes-into-hard-tissues-and-plaque
#4
Joel Moore, Eva Schneiderman, Teresa Farmer, Marianne Zsiska
OBJECTIVES: To compare the fluoridating potential of selected European toothpastes using a combination of enamel, dentin, and plaque in vitromodels. METHODS: Four in vitromodels were included: 1) Enamel Fluoride (F) Uptake (EFU); 2) Dentin F Uptake (DFU); 3) Enamel Solubility Reduction (ESR); and 4) Plaque F Uptake (PFU). A core set of marketed products was included in all studies, plus a standard toothpaste (1100 ppm F as NaF/silica) and placebo control (the PFU study did not include a placebo control)...
September 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29211358/chest-hrct-findings-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#5
Agata Sebastian, Maria Misterska-Skóra, Jurand Silicki, Maciej Sebastian, Piotr Wiland
BACKGROUND: Pulmonary manifestations (PMs) in primary Sjögren's syndrome (pSS) are among the most frequent extraglandular complications, with reported prevalence varying widely (9-75%), depending on the methods of detection. OBJECTIVES: The aim of this study was to assess the incidence of PMs in pSS and to determine the factors predisposing to the occurrence of this complication. MATERIAL AND METHODS: The study group consisted of 68 patients with pSS...
October 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29209130/circulating-mir-125a-but-not-mir-125b-is-decreased-in-active-disease-status-and-negatively-correlates-with-disease-severity-as-well-as-inflammatory-cytokines-in-patients-with-crohn-s-disease
#6
Chen-Ming Sun, Jie Wu, Heng Zhang, Gan Shi, Zhi-Tao Chen
AIM: To determine the association of circulating miR-125a/b expression with the risk and disease severity of Crohn's disease (CD), and with inflammatory cytokines. METHODS: Plasma samples were collected from patients with active CD (A-CD), or CD in remission (R-CD) and from healthy controls (HCs). The levels of the inflammatory cytokines interleukin-17 (IL-17), tumour necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) were measured by enzyme-linked immunosorbent assay...
November 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29207950/persistent-hematuria-in-patients-with-antineutrophil-cytoplasmic-antibody-associated-vasculitis-during-clinical-remission-chronic-glomerular-lesion-or-low-grade-active-renal-vasculitis
#7
Li Lv, Dong-Yuan Chang, Zhi-Ying Li, Min Chen, Zhao Hu, Ming-Hui Zhao
BACKGROUND: Whether persistent hematuria in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) during clinical remission reflects active disease or chronic glomerular injury is uncertain. This study aimed to investigate the significance of persistent hematuria during clinical remission in a large cohort of AAV patients. METHODS: A cohort of 219 AAV patients in complete clinical remission after induction therapy at our center was retrospectively studied, and their clinical and laboratory data as well as long-term outcomes were analyzed...
December 6, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29207750/validity-of-simplified-ankylosing-spondylitis-disease-activity-scores-sasdas-in-indian-ankylosing-spondylitis-patients
#8
Nagma Bansal, Lalit Duggal, Neeraj Jain
Introduction: Ankylosing Spondylitis Disease Activity Score (ASDAS) is a complex score for monitoring disease activity in Ankylosing Spondylitis (AS). Aim: To develop a simplified version of the ASDAS. Materials and Methods: Consenting 254 AS patients (modified New York and/or Assessment in Ankylosing Spondylitis 2009 criteria) were recruited. Sociodemographic data and disease characteristics such as Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), and AS Quality of Life (ASQoL), Erythrocyte Sedimentation Rate (ESR), and C-Reactive Protein (CRP) were collected...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205482/low-frequency-esr-studies-on-permeable-and-impermeable-deuterated-nitroxyl-radicals-in-corn-oil-solution
#9
D David Jebaraj, Hideo Utsumi, A Milton Franklin Benial
Low frequency electron spin resonance studies were performed for 2 mM concentration of deuterated permeable and impermeable nitroxyl spin probes, 3-methoxycarbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl and 3-carboxy-2,2,5,5,-tetramethyl-1-pyrrolidinyloxy in pure water and various concentrations of corn oil solution. The electron spin resonance parameters such as, the line width, hyperfine coupling constant, g-factor, rotational correlation time, permeability and partition parameter were estimated. The broadening of line width was observed for nitroxyl radicals in corn oil mixture...
December 4, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29205444/switching-from-infliximab-innovator-to-biosimilar-in-patients-with-inflammatory-bowel-disease-a-12-month-multicentre-observational-prospective-cohort-study
#10
E M H Schmitz, P J Boekema, J W A Straathof, D C van Renswouw, L Brunsveld, V Scharnhorst, M E C van de Poll, M A C Broeren, L J J Derijks
BACKGROUND: Infliximab biosimilars have become available for treatment of inflammatory bowel disease (IBD). However, data showing long-term safety and effectiveness of biosimilars in IBD patients are limited. AIM: To study prospectively the switch from infliximab innovator to biosimilar in an IBD cohort with 12 months follow-up to evaluate safety and effectiveness. METHODS: Adult IBD patients from two hospitals treated with infliximab innovator (Remicade; Janssen Biotech,  Horsham ,  Pennsylvania, USA) were switched to infliximab biosimilar (Inflectra; Hospira, Lake Forest, Illinois, USA) as part of routine care, but in a controlled setting...
December 5, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29205141/deep-spinal-infection-in-instrumented-spinal-surgery-diagnostic-factors-and-therapy
#11
M Dobran, A Marini, M Gladi, D Nasi, R Colasanti, R Benigni, Francesca Mancini, M Iacoangeli, M Scerrati
AIM: Postoperative surgical site infections (SSI) are complication of spinal surgery. These complications may lead to a poor outcome with neurological deficits, spinal deformity and chronic pain. The purpose of this study is to explore the statistical value of diagnostic parameters and the proper therapy. METHOD: We retrospectively reviewed 550 patients who underwent spinal instrumentation at our department from January 2011 to December 2015. The SSI was present in 16 patients out of 550 operated...
May 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29205120/synthesis-and-in-vitro-antioxidant-activity-study-of-some-novel-substituted-piperazinyl-flavone-compounds
#12
Elmas Sari, Paweł Berczynski, Aleksandra Kładna, Irena Kruk, Oya B Dundar, Monika Szymanska, Hassan Y Aboul-Enein
BACKGROUND: A new series of 13 piperazinyl flavone derivatives has been synthesized and examined for their in vitro antiradical and antioxidant activities as response to the pharmacy industry's increasing demand for new non-toxic anti-inflammatory and anticancer drugs. METHODS: Their antioxidant activity was evaluated by the reactive oxygen species (ROS) scavenging assays, 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH ) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical cation (ABTS+ ) scavenging assays, and the ferric reducing antioxidant potency (TAC) method, and compared to known positive controls, herbal infusions, and penicillins...
December 3, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/29204091/lipocalin-2-as-a-clinical-significance-in-rheumatoid-arthritis
#13
Arif Gulkesen, Gurkan Akgol, Ahmet K Poyraz, Suleyman Aydin, Affan Denk, Tulay Yildirim, Arzu Kaya
Aim of the study: In this study, serum lipokalin 2 (LCN-2) levels and its clinical and radiological significance in patients with rheumatoid arthritis was evaluated. Material and methods: The study enrolled 37 patients with RA and 34 healthy controls. Serum LCN-2 level was measured using ELISA method. Patients with DAS 28 scores ≤ 3.2, and > 3.2 were allocated into lower and high/moderate disease activity groups, respectively. Additionally patients were divided into 2 groups as early RA (disease duration ≤ 2 years) and established RA (duration of the disease ≥ 2 years)...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29204090/autoantibodies-c-reactive-protein-erythrocyte-sedimentation-rate-and-serum-cytokine-profiling-in-monitoring-of-early-treatment
#14
Edyta Brzustewicz, Izabella Henc, Agnieszka Daca, Maria Szarecka, Malgorzata Sochocka-Bykowska, Jacek Witkowski, Ewa Bryl
Introduction: Currently used clinical scale and laboratory markers to monitor patients with early rheumatoid arthritis (RA) seem to be not sufficient. It has been demonstrated that disease- related cytokines may be elevated very early in RA development and cytokines are considered as the biomarkers potentially useful for RA monitoring. Material and methods: The group of patients with undifferentiated arthritis (UA) developing RA (UA→RA) was identified from a total of 121 people with arthralgia...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29202743/posterior-intervertebral-space-debridement-annular-bone-grafting-and-instrumentation-for-treatment-of-lumbosacral-tuberculosis
#15
Weiwei Li, Jun Liu, Liqun Gong, Yongchun Zhou, Dapeng Duan
BACKGROUND: The choice of surgical methods for lumbosacral tuberculosis is controversial due to the complex anterior anatomy and peculiar biomechanics of the lumbosacral junction. The objective of this study was to explore the clinical effect of posterior intervertebral space debridement with annular bone graft fusion and fixation for the treatment of lumbosacral tuberculosis. METHODS: We retrospectively analysed data from 23 patients with lumbosacral tuberculosis who had undergone posterior intervertebral space debridement with annular bone fusion and fixation between January 2008 and September 2014...
December 4, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29201209/correlation-of-the-expression-of-mir-146a-in-peripheral-blood-mononuclear-cells-of-patients-with-ankylosing-spondylitis-and-inflammatory-factors
#16
Chengjun Wei, Hongxia Zhang, Chenghong Wei, Youyan Mao
We investigated the expression of miR-146a in peripheral blood mononuclear cell (PBMC) of patients with ankylosing spondylitis (AS) and its correlation with inflammatory factors to explore the clinical significance. In total 45 patients with AS were selected at the Weifang People's Hospital from June, 2014 to January, 2016. At the same time, 30 healthy volunteers were also selected to serve as control group. Expression level of miR-146a in PBMC cells of patients in each group was detected by quantitative real-time-polymerase chain reaction (qRT-PCR)...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29200816/multivariable-prediction-model-for-suspected-giant-cell-arteritis-development-and-validation
#17
Edsel B Ing, Gabriela Lahaie Luna, Andrew Toren, Royce Ing, John J Chen, Nitika Arora, Nurhan Torun, Otana A Jakpor, J Alexander Fraser, Felix J Tyndel, Arun Ne Sundaram, Xinyang Liu, Cindy Ty Lam, Vivek Patel, Ezekiel Weis, David Jordan, Steven Gilberg, Christian Pagnoux, Martin Ten Hove
Purpose: To develop and validate a diagnostic prediction model for patients with suspected giant cell arteritis (GCA). Methods: A retrospective review of records of consecutive adult patients undergoing temporal artery biopsy (TABx) for suspected GCA was conducted at seven university centers. The pathologic diagnosis was considered the final diagnosis. The predictor variables were age, gender, new onset headache, clinical temporal artery abnormality, jaw claudication, ischemic vision loss (VL), diplopia, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and platelet level...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29196383/opioid-analgesic-use-in-patients-with-ankylosing-spondylitis-an-analysis-of-the-prospective-study-of-outcomes-in-an-ankylosing-spondylitis-cohort
#18
Jonathan D Dau, MinJae Lee, Michael M Ward, Lianne S Gensler, Matthew A Brown, Thomas J Learch, Laura A Diekman, Amirali Tahanan, Mohammad H Rahbar, Michael H Weisman, John D Reveille
OBJECTIVE: Opioid analgesics may be prescribed to ankylosing spondylitis (AS) patients with pain that is unresponsive to antirheumatic treatment. Our study assessed factors associated with opioid usage in AS. METHODS: A prospective cohort of 706 patients with AS meeting modified New York criteria followed at least 2 years underwent comprehensive clinical evaluation of disease activity and functional impairment. These were assessed by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI)...
December 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29192918/external-oxidant-free-cross-coupling-electrochemically-induced-aromatic-c-h-phosphonation-of-azoles-with-dialkyl-h-phosphonates-under-silver-catalysis
#19
E O Yurko, T V Gryaznova, K V Kholin, V V Khrizanforova, Y H Budnikova
A convenient external oxidant-free method of phosphorylation of azole derivatives (benzo-1,3-azoles, 3-methylindole, 4-methyl-2-acetylthiazole) by using dialkyl-H-phosphonates through the catalytic oxidation of their mixture under electrochemical mild conditions (room temperature, normal pressure) in the presence of silver salts or oxide (1%) is proposed. This method allows us to obtain the desired azole dialkylphosphonates with good yield (up to 75%). The transformations of silver and phosphorus precursors and intermediates using cyclic voltammetry, ESR, and NMR spectroscopy were investigated, and a radical process mechanism was proposed...
December 1, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29192568/-polymyalgia-rheumatica-new-developments-and-challenges
#20
D E Marsman, A A den Broeder, N Boers, A van der Maas
- Polymyalgia rheumatica (PMR) is an inflammatory rheumatic disorder in which inflammation markers, both erythrocyte sedimentation rate (ESR) and CRP values, are often elevated. However, a non-abnormal ESR or CRP value does not preclude the diagnosis.- PMR is an arbitrary diagnosis and presents both diagnostic and therapeutic challenges.- Imaging diagnostics, such as echography, MRI or FDG-PET/CT, may potentially be applied more frequently as a second-line investigation when there is doubt concerning the diagnosis...
2017: Nederlands Tijdschrift Voor Geneeskunde
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