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https://www.readbyqxmd.com/read/28723775/the-neutrophil-to-lymphocyte-ratio-could-be-a-good-diagnostic-marker-and-predictor-of-relapse-in-patients-with-adult-onset-still-s-disease-a-strobe-compliant-retrospective-observational-analysis
#1
Ji-Yeoun Seo, Chang-Hee Suh, Ju-Yang Jung, Ar-Reum Kim, Ji Won Yang, Hyoun-Ah Kim
The neutrophil-to-lymphocyte ratio (NLR) is the proportion of absolute neutrophil count to lymphocytes on routine complete blood count (CBC) tests, and has been studied as a simple marker of the systemic inflammatory response. This study was performed to investigate whether the NLR could be used as a tool to diagnose and predict prognosis in cases of adult-onset Still's disease (AOSD).We retrospectively reviewed 164 patients with suspected AOSD. Among 164 patients with suspected AOSD, 37 patients received another diagnosis (such as viral infection) and were compared with the 127 patients who received a diagnosis of AOSD...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28717662/clinical-and-molecular-characterization-of-cystinuria-in-a-french-cohort-relevance-of-assessing-large-scale-rearrangements-and-splicing-variants
#2
Pascaline Gaildrat, Said Lebbah, Abdellah Tebani, Bénédicte Sudrié-Arnaud, Isabelle Tostivint, Guillaume Bollee, Hélène Tubeuf, Thomas Charles, Aurelia Bertholet-Thomas, Alice Goldenberg, Frederic Barbey, Alexandra Martins, Pascale Saugier-Veber, Thierry Frébourg, Bertrand Knebelmann, Soumeya Bekri
BACKGROUND: Cystinuria is an autosomal recessive disorder of dibasic amino acid transport in the kidney and the intestine leading to increased urinary cystine excretion and nephrolithiasis. Two genes, SLC3A1 and SLC7A9, coding respectively for rBAT and b0,+AT, account for the genetic basis of cystinuria. METHODS: This study reports the clinical and molecular characterization of a French cohort including 112 cystinuria patients and 25 relatives from 99 families. Molecular screening was performed using sequencing and Quantitative Multiplex PCR of Short Fluorescent Fragments analyses...
July 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28714337/correlation-between-natural-killer-cell-activity-and-systemic-inflammatory-markers-for-heterogeneous-cancer-patients-treated-with-wheel-balance-cancer-therapy
#3
Hwi-Joong Kang, Kyeore Bae, Jee-Hye Kim, Chong-Kwan Cho, Hwa-Seung Yoo
BACKGROUND AND OBJECTIVE: Natural killer (NK) cells are known to have an effect on the prevention of tumorigenesis for the initial cancer, as well as the metastatic cancer. For the past several years, the relationship between cancer and inflammation has been actively studied in preclinical and clinical settings, but there are no reports on alterations in and correlation for NK cell activity (NKA) and systemic inflammatory markers. Accordingly, this study aimed to measure correlation between NKA and the levels of other systemic inflammatory markers in patients with gastric, breast, and pancreatic cancer who received Wheel Balance Cancer Therapy (WBCT)...
July 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28712799/diagnosing-periprosthetic-joint-infection-and-the-winner-is
#4
Alisina Shahi, Timothy L Tan, Michael M Kheir, Dean D Tan, Javad Parvizi
BACKGROUND: Diagnosis of periprosthetic joint infection (PJI) remains a challenge despite a wide variety of available diagnostic tests. The question that arises is which of these tests has a better performance for diagnosing PJI. Diagnostic odds ratio (DOR) has been described as the best indicator for test performance. METHODS: To compare the performance of the standard diagnostic tests, the DOR of serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), synovial fluid (SF) white blood cell (WBC) count, SF polymorphonuclear (PMN%), and leukocyte esterase (LE) were calculated...
June 10, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28712673/extract-critical-factors-affecting-the-length-of-hospital-stay-of-pneumonia-patient-by-data-mining-case-study-an-iranian-hospital
#5
Naghmeh Khajehali, Somayeh Alizadeh
MOTIVATION: Pneumonia is a prevalent infection of lower respiratory tract caused by infected lungs. Length of stay (LOS) in hospital is one of the simplest and most important indicators in hospital activity that is used for different purposes. The aim of this study is to explore the important factors affecting the LOS of patients with pneumonia in hospitals. METHODS: The clinical data set for the study were collected from 387 patients in a specialized hospital in Iran between 2009 and 2015...
July 13, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/28711272/the-infection-of-mycoplasma-hominis-after-total-knee-replacement-case-report-and-literature-review
#6
Hong-Jiu Qiu, Wei-Ping Lu, Min Li, Zi-Ming Wang, Quan-Yin Du, Ai-Min Wang, Yan Xiong
The Mycoplasma hominis infection is a rare postoperative complication after joint replacement. Based on our knowledge, there were only two cases reported by Korea all over the world currently. A case of postoperative Mycoplasma hominis infection after total knee replacement in our hospital was reported in this article. It was confirmed through mass spectrometer and Mycoplasma cultivation and treated by the first stage debridement, polyethylene insert replacement, and then drainage and irrigation combined with sensitive antibiotics after the operation...
June 22, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28709561/factors-associated-with-need-for-revascularisation-in-non-coronary-arterial-occlusive-lesions-secondary-to-takayasu-s-arteritis
#7
C A Hinojosa, J E Anaya-Ayala, Z Gomez-Arcive, H Laparra-Escareno, A Torres-Machorro, R Lizola
OBJECTIVE/BACKGROUND: Takayasu's arteritis (TA) is rare inflammatory large vessel form of vasculitis. The objective of this study was to evaluate experience in the management of TA patients and to identify the influence of inflammatory markers and clinical variables associated with disease progression, worsening ischaemic symptoms, and the need for interventions. METHODS: Demographics, and laboratory and clinical variables in patients that required revascularisation procedures were compared with those who had adequate symptomatic control with medical management...
July 11, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28709490/serum-levels-of-soluble-urokinase-plasminogen-activator-receptor-supar-as-a-marker-of-tuberculosis-treatment-efficacy
#8
V Indumati, V Vijay, D Krishnaswamy, V Rajeshwari, A Ramesh, D Shantala, A Shilpa
BACKGROUND: Upon diagnosis, Pulmonary Tuberculosis patients are treated for TB for a period of 6-9 months. At present, there exists very little indication of the efficacy of the particular treatment. A few previous studies have shown that soluble urokinase plasminogen activator receptor (SuPAR) may be used as treatment efficacy marker. SuPAR is a cellular receptor for serine protease urokinase plasminogen activator (uPA). Bacterial endotoxins and cytokines of the innate immune system stimulate the secretion of uPA in monocytes & neutrophils...
July 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28707746/gas-evolution-in-activated-carbon-based-supercapacitors-using-protic-deep-eutectic-solvent-as-electrolyte
#9
Satyajit Phadke, Samia Amara, Meriem Anouti
One of the primary causes of ageing in supercapacitors are the irreversible faradaic reactions occurring near the operating voltage limit which lead to the production of gases resulting in device swelling, increased resistance (ESR), and lowering of the capacitance. In this study, we report a investigation of a protic "Deep Eutectic Solvent" (DES) consisting on mixture of Lithium bis(fluorosulfonyl)imide salt (LiFSI) with formamide (FMD) as H-bond donor (xLiFSI = 0.25 ; C = 2.5 M LiFSI) as electrolyte for AC based EDLC...
July 14, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28705467/sarcoidosis-with-fever-and-a-splenic-infarct-due-to-cmv-or-lymphoma
#10
REVIEW
Burke A Cunha, Thulashie Sivarajah, Ismail Jimada
We present a case of an adult female with a past history of pulmonary sarcoidosis who presented with fever, night sweats, profound fatigue, and LUQ abdominal pain. Sarcoidosis is an afebrile disorder (excluding Lofgren's syndrome, Heerfordt's syndrome or neurosarcoidosis). Therefore, the presence of fever with sarcoidosis should suggest infection, usually viral, or lymphoma. Sarcoidosis-lymphoma syndrome describes the evolution of a lymphoma in long standing sarcoidosis. Fever aside, possible lymphoma is suggested by otherwise unexplained fever, pleural unilateral effusion, highly elevated ESR or ferritin levels...
July 10, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/28705257/single-stage-transforaminal-decompression-debridement-interbody-fusion-and-posterior-instrumentation-for-lumbosacral-brucellosis
#11
Yakefu Abulizi, Wei-Dong Liang, Aikeremujiang Muheremu, Maierdan Maimaiti, Wei-Bin Sheng
BACKGROUND: Spinal brucellosis is a less commonly reported infectious spinal pathology. There are few reports regarding the surgical treatment of spinal brucellosis in existing literature. This retrospective study was conducted to determine the effectiveness of single-stage transforaminal decompression, debridement, interbody fusion, and posterior instrumentation for lumbosacral spinal brucellosis. METHODS: From February 2012 to April 2015, 32 consecutive patients (19 males and 13 females, mean age 53...
July 14, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28701681/inflammation-is-associated-with-platelet-coagulation-function-rather-than-enzymatic-coagulation-function-in-patients-with-takayasu-arteritis
#12
Xiao Wang, Aimin Dang, Naqiang Lv, Nan Cheng, Xuesen Cheng
The integral changes of coagulation and fibrinolysis, and their relationships with inflammation in patients with Takayasu arteritis (TA) remain undetermined. The purpose of this study was to analyze the changes of coagulation and fibrinolysis process in patients with TA by thrombelastography (TEG).A total of 127 patients with TA and 55 healthy controls were enrolled. Patients with TA were grouped according to disease activity. The routine hematological parameters, traditional coagulation assays, and TEG parameters were summarized retrospectively...
July 13, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28695434/the-single-nucleotide-polymorphism-snp-of-tumor-necrosis-factor-%C3%AE-308g-a-gene-is-associated-with-early-onset-primary-knee-osteoarthritis-in-an-egyptian-female-population
#13
Sahar M Abdel Galil, Nillie Ezzeldin, Faten Fawzy, Mohamed El-Boshy
The objective of the present study is to investigate if there is a potential association between the single-nucleotide polymorphisms (SNPs) of the tumor necrosis factor alpha gene (TNF-α -308G/A, rs1800629) and the susceptibility to and severity of early-onset knee osteoarthritis in the Egyptian female population. Genotype distributions and allelic frequencies of TNF-α -308G/A polymorphism were investigated in 210 knee osteoarthritis (OA) patients and 210 age-, sex-, and ethnicity-matched healthy controls (HC)...
July 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28694863/kinetic-analysis-of-mechanoradical-formation-during-the-mechanolysis-of-dextran-and-glycogen
#14
Naoki Doi, Yasushi Sasai, Yukinori Yamauchi, Tetsuo Adachi, Masayuki Kuzuya, Shin-Ichi Kondo
A detailed electron spin resonance (ESR) analysis of mechanically induced free radicals (mechanoradicals) formation of glucose-based polysaccharides, dextran (Dx) and glycogen (Gly) was performed in comparison with amylose mechanoradicals. The ESR spectra of the samples mechanically fractured at room temperature were multicomponent. The radical concentration of Dx and Gly mechanoradicals gradually decreased during vibratory milling after reaching the maximum value. Although the molecular weight of Dx or the particle diameter of Gly steeply diminished until reaching the each maximum value of radical concentration, after that the molecular weight or the particle diameter slowly decreased...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28694300/the-regulation-of-oxytocin-and-oxytocin-receptor-in-human-placenta-according-to-gestational-age
#15
Seung Chul Kim, Jae-Eon Lee, Seong Soo Kang, Hoe-Saeng Yang, Sun Suk Kim, Beum-Soo An
Oxytocin (OXT) is a peptide hormone that plays a central role in the regulation of parturition and lactation in the uterus. OXT signaling is mediated by OXT receptor (OXTR), which shows species- and tissue-specific expressions and gene regulation. In the present study, we examined synthesis of OXT and OXTR in human placenta tissue according to gestational age. A total of 48 placentas were divided into early preterm, late preterm, and term groups depending on gestational age, and expression of OXT and OXTR was evaluated...
July 10, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28693070/-expression-of-annexin-a1-in-peripheral-blood-cells-of-na%C3%A3-ve-rheumatoid-arthritis-patients-and-its-influencing-factors
#16
Y F Mei, S M Dai, H N Jia, Z G Lin, Z Y Zhang
Objective: To explore the expression of Annexin a1 (AnxA1) mRNA in peripheral blood mononuclear cells (PBMC) from Naïve rheumatoid arthritis (RA) patients and healthy controls and to investigate its influencing factors. Methods: Thirty Naïve RA patients and 36 healthy controls were recruited from the First Affiliated Hospital of Harbin Medical University between May 2013 and January 2015.All RA patients were fulfilled the classification criteria of ACR in 1987.Clinical characteristics and laboratory indexes were collected...
July 4, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28690466/propionibacterium-acnes-host-inflammatory-response-during-periprosthetic-infection-is-joint-specific
#17
Scott R Nodzo, K Keely Boyle, Samrath Bhimani, Thomas R Duquin, Andy O Miller, Geoffrey H Westrich
BACKGROUND: Propionibacterium acnes (P. acnes) has become increasingly recognized as a cause of periprosthetic joint infection (PJI). QUESTIONS/PURPOSES: It is not currently known if the clinical presentation of P. acnes varies depending on the joint being infected. METHODS: We retrospectively reviewed patients infected with P. acnes after total hip, knee, and shoulder arthroplasty from two institutions. Patients were classified as having a PJI based on the Musculoskeletal Infection Society criteria and were excluded if they had a polymicrobial culture...
July 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28685470/construction-of-0-15-tesla-overhauser-enhanced-mri
#18
Yuumi Tokunaga, Motonao Nakao, Tatsuya Naganuma, Kazuhiro Ichikawa
Overhauser enhanced MRI (OMRI) is one of the free radical imaging technologies and has been used in biomedical research such as for partial oxygen measurements in tumor, and redox status in acute oxidative diseases. The external magnetic field of OMRI is frequently in the range of 5-10 mTesla to ensure microwave penetration into small animals, and the S/N ratio is limited. In this study, a 0.15 Tesla OMRI was constructed and tested to improve the S/N ratio for a small sample, or skin measurement. Specification of the main magnet was as follows: 0...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28685302/anti-arthritic-activity-of-cell-wall-content-of-lactobacillus-plantarum-in-freund-s-adjuvant-induced-arthritic-rats-involvement-of-cellular-inflammatory-mediators-and-other-biomarkers
#19
Priyanshee Gohil, Vimal Patel, Shrikalp Deshpande, Mehul Chorawala, Gaurang Shah
Alteration of microbiota is related with rheumatoid arthritis (RA) and administration of certain probiotics showed an improvement in RA. The present study was designed to find out the anti-arthritic activity of cell wall content of Lactobacillus plantarum in complete Freund's adjuvant (CFA)-induced arthritis in rats. Freund's adjuvant was injected into the left footpad in female rats on day 0 and dexamethasone (1 mg kg(-1), s.c.) & cell wall content of L. plantarum (10(5), 10(7), and 10(9) cfu/animal, s...
July 6, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28684998/bioactive-m-ii-complexes-of-amino-acid-based-n3o-donor-mixed-ligand-in-vitro-and-in-silico-dna-binding-studies
#20
T Daniel Prakash, V Violet Dhayabaran
Three novel mixed ligand M(II) complexes, namely [CoL(1)L(2)Cl2] (1), [CuL(1)L(2)Cl2] (2), and [ZnL(1)L(2)Cl2] (3), were synthesized using 1,4-naphthoquinone, L-histidine, and 1,10-phenanthroline as ligands. The ligand framework and the corresponding structural changes on complexation were ascertained based on the results of elemental analysis, conductivity measurements, magnetic behavior, FT-IR, UV-visible, (1)H NMR, (13)C NMR, ESR spectral studies, and ESI mass spectrometry. The biological action of the ligand (L) and complexes 1-3 such as DNA binding and cleaving ability were studied...
July 2017: Journal of Chemical Biology
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