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Cristina Lussi, Angela Frotzler, Andreas Jenny, Dirk J Schaefer, Reto W Kressig, Anke Scheel-Sailer
STUDY DESIGN: Retrospective chart review. OBJECTIVES: To describe (i) the nutritional blood parameters (NBP) and the nutritional risk screening (NRS) in patients with spinal cord injury (SCI) and pressure ulcers (PU) III and IV according to the EPUAP classification, and (ii) the relationship between both NBP and NRS. SETTING: SCI acute care and rehabilitation clinic in Switzerland. METHODS: The NBPs were measured upon the admission of patients treated for PU III and IV between 11/2011 and 12/2014...
October 23, 2017: Spinal Cord
Hai Chen, Fangju Lin, Shimeng Liu, Yuwei Da, Dongmei Guo
OBJECTIVE: To present detailed information regarding these aspects in Human Immunodeficiency Virus (HIV)-infected patients making an effort to improve the recognition of neurological complications of HIV infection. METHODS: This retrospective study analyzed the clinical manifestations, laboratory and neuroimaging results of HIV-infected patients with neurological complications at Xuanwu hospital, Beijing, China from January 2011 to December 2014, one of top-rated hospitals in Beijing, China...
October 2017: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
Jinmei Wang, Pengli Lian, Qi Yu, Jinfeng Wei, Wenyi Kang
The blackberry seed was typically removed as a byproduct and waste from blackberry fruits for juices. Developing value-added utilization of berry seeds will significantly expand the market for berry products as well as improve benefit to berry producers. However, the research on blackberry seed is limited. The objective of this paper was to research antithrombotic mechanism of polysaccharides in blackberry seeds. Polysaccharides in blackberry seeds were extracted, purified and identified by high-performance gel permeation chromatography (HPSEC), gas chromatography (GC), fourier transform infrared (FT-IR) spectrometer and nuclear magnetic resonance spectra (NMR)...
2017: Food & Nutrition Research
Agata Sebastian, Patryk Wojtala, Łukasz Lubiński, Małgorzata Mimier, Arkadiusz Chlebicki, Piotr Wiland
OBJECTIVE: Use of tumour necrosis factor inhibitors (TNFi) has proved to be an important step forward in the treatment of axial spondyloarthritis (axSpA), but the duration of the therapy as well as the management in case of low disease activity (LDA) or remission are not clearly established. Currently, the identification of potential predictors associated with the treatment discontinuation is the basic purpose of many clinical studies. The aim of this study was to analyze the influence of the discontinuation of TNFi therapy on the disease activity in patients with low disease activity...
2017: Reumatologia
Alex L Lai, Jean K Millet, Susan Daniel, Jack H Freed, Gary R Whittaker
Coronaviruses are a major infectious disease threat, and include the pathogenic human pathogens of zoonotic origin: SARS-CoV and MERS-CoV. Entry of coronaviruses into host cells is mediated by the viral spike (S) protein, which is structurally categorized as a class I viral fusion protein, within the same group as influenza virus and HIV. However, S proteins have two distinct cleavage sites that can be activated by a much wider range of proteases. The exact location of the coronavirus fusion peptide (FP) has been disputed...
October 19, 2017: Journal of Molecular Biology
Akihiro Ito, Masashi Uebe, Tatsuya Kazama, Ryohei Kurata, Daisuke Sakamaki
Radical cations of bis(triarylamine)s, 3 and 4, in which the triarylamine redox centers are bridged by ortho-phenylene and ortho-carborane cluster, respectively, have been prepared to elucidate the difference in intramolecular charge/spin transfer (ICT/IST) pathway due to the two different bridging units affording similar geometrical arrangements between the redox centers. Electrochemistry, absorption spectroscopy, VT-ESR spectroscopy, and DFT calculations reveal that 3*+ and 4*+ are classified into class-II and class-I mixed valence systems, respectively, and therefore, through-bond and through-space mechanisms are dominant for the ICT/IST phenomena in 3*+ and 4*+, respectively...
October 19, 2017: Angewandte Chemie
Yi Xu, Steven Qian
Redox signaling plays important roles in regulating pulmonary vasculature function. Aberrant redox signaling, e.g., overproduction of reactive oxygen species (ROS) that exceeds the capability of cellular antioxidant mechanisms, has been found to alter vasculature function and remodel blood vessel structure, thus contributes to pathological processes of pulmonary vasculature. The regulation of pulmonary vasculature via ROS is a very complicated process with various biological events involved, however, the specific effect of individual ROS and the underlying mechanism still remain unclear...
2017: Advances in Experimental Medicine and Biology
Biju Basumatary, Jyoti Rai, R V Ramana Reddy, Jeyaraman Sankar
One-electron oxidation of a Ga(III)-corrole with N(4-BrC6H4)3SbCl6 resulted in an air-stable non-innocent Ga(III)-corrole radical. Single crystal X-ray crystallography of 1,18-bisformyl[(TPFC)Ga(III)-Cl]* revealed delocalization of the unpaired electron, which was further confirmed by electron spin resonance (ESR) spectroscopy and spin density distribution plot. In addition, the nucleus-independent chemical shift (NICS), anisotropy induced-current density (AICD) and harmonic oscillator model of aromaticity (HOMA) supported a [17] pi-electron conjugated (or antiaromatic) radical...
October 18, 2017: Chemistry: a European Journal
Mingyue Zhu, Qian Liu, Wei Chen, Yuanyuan Yin, Lan Ge, Henan Li, Kun Wang
The efficient separation of photogenerated electron-hole pairs in photoactive materials is highly desired, allowing their transfer to specific sites for undergoing redox reaction in various application. The construction of ternary heterojunctions is a practical strategy to enhance the migration of photogenerated electron that realizes the synergistic effect of multi-components rather than the simple overlay of single component. Here, we demonstrate an available way to fabricate new BiOCl/BiVO4/nitrogen-doped graphene quantum dots (N-GQDs) ternary heterojunctions that exhibit higher efficiency in charge separation than any binary heterojunctions or pure materials under visible light irradiation...
October 18, 2017: ACS Applied Materials & Interfaces
Huajun Xu, Yingchun Zhang, Huimei Zhang, Caishan Wang, Pan Mao
BACKGROUND: As an irreversible disease, a treatment delay can negatively affect treatment response in rheumatoid arthritis (RA). Ultrasound and MRI have played an important role in assessing disease progression and response to treatment in RA for many years. The present study was designed to compare the diagnostic efficacy of ultrasound grading and MRI in early RA. METHODS: In this retrospective study, 62 early RA patients within 12 months of symptom onset were included...
October 17, 2017: Journal of Orthopaedic Surgery and Research
Laís Uyeda Aivazoglou, Orlando Rondan Zotti, Marcelo de Medeiros Pinheiro, Moacir Ribeiro de Castro Junior, Andrea Puchnick, Artur da Rocha Corrêa Fernandes, Eloy de Ávila Fernandes
OBJECTIVE: To evaluate the imaging features of spondyloarthritis in magnetic resonance imaging (MRI) of the sacroiliac (SI) joint and topography (in thirds) and affected margin, considering that this issue is rarely addressed in the literature. METHODS: A cross-sectional study evaluating MRI (1.5T) of SI in 16 patients with axial spondyloarthritis, for the presence of acute (subchondral bone edema, enthesitis, synovitis and capsulitis) and chronic (erosions, subchondral bone sclerosis, bony bridges, and fatty infiltration) changes, performed by two blinded radiologists...
September 2017: Revista Brasileira de Reumatologia
Ying Sun, Lili Ma, Lingying Ma, Xiufang Kong, Huiyong Chen, Peng Lv, Jiang Lin, Hao Liu, Yan Yan, Zongfei Ji, Chengde Yang, Shengming Dai, Weiguo Wan, Yaohong Zou, Xuejuan Jin, Lindi Jiang
To assess the effectiveness of cyclophosphamide (CYC) versus methotrexate (MTX) for active Takayasu's arteritis (TA). The current study was based on a cohort of TA at Zhongshan Hospital, Fudan University. TA was diagnosed using the 1990 American College of Rheumatology criteria. Fifty-eight subjects receiving induction treatment with CYC (n = 46) or MTX (N = 12) were included in the analysis. Effectiveness and toxicity were assessed in all 58 cases. Clinical remission was defined as: Kerr score reduction to ≤ 1 and glucocorticoids (GC) treatment at a dose of ≤ 0...
October 13, 2017: Rheumatology International
Julien Lopez, Zuzana Tatar, Anne Tournadre, Marion Couderc, Bruno Pereira, Martin Soubrier, Jean-Jacques Dubost
BACKGROUND: Coagulase-negative staphylococci (CoNS) are increasingly implicated in recent patient series of spondylodiscitis, but there are no series of CoNS-spondylodiscitis available. The objective of this study was to compare the characteristics of patients with spontaneous CoNS-spondylodiscitis with those patients with Staphylococcus aureus (SA) spondylodiscitis. METHODS: This was a retrospective single center study involving 147 spontaneous infectious spondylodiscitis cases observed between 2000 and 2015...
October 13, 2017: BMC Infectious Diseases
W Th Wenckebach
Dynamic Nuclear Polarization (DNP) has proven itself most powerful for the orientation of nuclear spins in polarized targets and for hyperpolarization in magnetic resonance imaging (MRI). Unfortunately, the theoretical description of some of the processes involved in DNP invokes the high temperature approximation, in which Boltzmann factors are expanded up to first order, while the high electron and nuclear spin polarization required for many applications do not justify such an approximation. A previous article extended the description of one of the mechanisms of DNP-thermal mixing-beyond the high temperature approximation (Wenckebach, 2017)...
October 4, 2017: Journal of Magnetic Resonance
Lois Lamerato, Kylie Matthews, Kwanza Price, Alan Szymialis, Michael Eaddy, Augustina Ogbonnaya, Huai-Che Shih, Harris Ahmad
BACKGROUND: Anti-cyclic citrullinated peptide (CCP) antibody positivity is an established diagnostic factor for severe disease activity and joint damage and a prognostic factor for aggressive disease in rheumatoid arthritis (RA). OBJECTIVE: To compare RA-related treatment, healthcare utilization, and joint erosion between anti-CCP-positive and anti-CCP-negative RA patients. METHODS: Newly diagnosed RA patients were identified from the Henry Ford Health System database between 1/1/2009 and 12/31/2014; the date of the first RA diagnosis within the study period was the index date...
October 13, 2017: Journal of Medical Economics
Suparaporn Wangkaew, Narawudt Prasertwitayakij, Arintaya Phrommintikul, Saowanee Puntana, Juntima Euathrongchit
Inception cohort study regarding the causes of death and risk factors for mortality in patients with early systemic sclerosis (SSc), especially diffuse SSc (dcSSc) has not been well elucidated. Therefore, the aim of our study was to determine the causes of death, survival rates, and risk factors for mortality in Thai patients with early SSc of whom the majority belonged to the dcSSc subset. We used an inception cohort of early-SSc patients seen between January 2010 and August 2014. All patients were evaluated for clinical and laboratory data at the study entry and then every 6 months...
October 12, 2017: Rheumatology International
Andrea Delle Sedie, Lucrezia Riente, Lavinia Maggiorini, Federico Pratesi, Antonio Tavoni, Paola Migliorini, Ilaria Puxeddu
AIM: Reduced capillary density is considered the hallmark of systemic sclerosis (SSc) leads to tissue hypoxia, a condition that usually induces angiogenesis. The objective of our study is to investigate mediators regulating angiogenesis in SSc and to correlate their levels with serological and clinical parameters. METHODS: vascular endothelial growth factor, fibroblast growth factor-2, endostatin, thrombospondin-1 and soluble vascular cell and intracellular adhesion molecules (sICAM-1 and sVCAM-1) were measured in sera of SSc and normal subjects by enzyme-linked immunosorbent assay...
October 11, 2017: International Journal of Rheumatic Diseases
Vladimir G Sokolov, Tatyana S Koptseva, Mikhail V Moskalev, Natalia L Bazyakina, Alexander V Piskunov, Anton V Cherkasov, Igor L Fedushkin
The reaction of Cl2GaH with a sodium salt of the dpp-Bian radical-anion (dpp-Bian(•-))Na (dpp-Bian = 1,2-bis[(2,6-diisopropylphenyl)imino]acenaphthene) affords paramagnetic gallane (dpp-Bian(•-))Ga(Cl)H (1). Oxidation of (dpp-Bian(2-))Ga-Ga(dpp-Bian(2-)) (2) with N2O results in the dimeric oxide (dpp-Bian(•-))Ga(μ(2)-O)2Ga(dpp-Bian(•-)) (3). A treatment of the oxide 3 with phenylsilane affords paramagnetic gallium hydrides (dpp-Bian(•-))GaH2 (4) and (dpp-Bian(•-))Ga{OSi(Ph)H2}H (5) depending on the reagent's stoichiometry...
October 12, 2017: Inorganic Chemistry
Karumutchu Sitalu, B Hari Babu, J Naveena Lavanya Latha, A Lakshmana Rao
BACKGROUND: Caffeine, 1, 3, 7-trimethylxanthine is one of the xanthine derivatives that are for the most part utilized as a part of solutions as diuretics. The Cu (II) complexes have been synthesized from the N-heterocyclic carbene ligands. MATERIALS AND METHODS: The Cu (II) NHC complexes were characterized using analytical and spectral techniques. Antibacterial and antifungal activities of the Cu (II) NHC complexes were determined using the reported techniques...
2017: Pakistan Journal of Biological Sciences: PJBS
Chandana Chakraborti, Krittika Pal Choudhury, Jayanta Das
BACKGROUND: Orbital tuberculosis is a rare manifestation of extrapulmonary tuberculosis. We report an interesting case of osteomyelitis of orbital bone in an Indian child. CASE REPORT: A 9- year old girl presented with a gradually increasing painless swelling of left upper lid and blepharoptosis along with swelling of left side of forehead for last two months. The swelling was soft, fluctuating and non-tender. Diagnostic tap revealed thick pus which prompted us to do an incisional drainage of the abscess...
January 2017: Nepalese Journal of Ophthalmology
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