keyword
https://read.qxmd.com/read/38524883/severe-pulmonary-hypertension-and-pulmonary-thrombi-in-a-dog
#1
Heidi B Kellihan, Elizabeth Cutchin, Anna Sirochman, David Gasper
• PAs can protrude from the lung with severe obstruction and dilation. • Dogs can develop PT secondary to protein-losing nephropathy. • Evidence of classic histopathologic changes associated with chronic PH was present. • Dogs can live with chronic severe PA obstruction and severe PH secondary to PT.
March 2024: CASE: Cardiovascular Imaging Case Reports
https://read.qxmd.com/read/38516467/mortality-analysis-in-geriatric-patients-with-acute-kidney-injury-admitted-in-the-intensive-care-unit-a-single-center-cross-sectional-study
#2
JOURNAL ARTICLE
Girish V Kumthekar, Veena Purandare, Manasi Nagarkar, Shruti Paramshetti
Introduction Acute kidney injury (AKI) is an abrupt reduction in kidney function that causes nitrogenous waste and other waste products to be retained. Methods This cross-sectional study was conducted from February 2015 to January 2016. The study received approval from the Independent Ethics Committee, which included patients over 60 with AKI. The study duration was 12 consecutive months to ascertain the etiology, severity, and hospital outcomes of AKI. Results The common etiologies of AKI included drug-induced (25%), age-related (21...
February 2024: Curēus
https://read.qxmd.com/read/38505156/the-challenging-management-of-malignant-ureteral-obstruction-analysis-of-a-series-of-188-cases
#3
JOURNAL ARTICLE
Alberto Artiles Medina, Inés Laso García, Fernando González Tello, Sara Álvarez Rodríguez, Manuel Hevia Palacios, Marina Mata Alcaraz, César Mínguez Ojeda, Fernando Arias Funez, Victoria Gómez Dos Santos, Francisco Javier Burgos Revilla
BACKGROUND: Malignant ureteral obstruction (MUO) is a common condition that complicates the course of advanced malignancies. The aims of this study are to analyze the causes, management, and survival of patients with obstructive nephropathy due to malignant ureteric obstruction and to determine prognostic factors. Furthermore, we studied the complications and outcomes in patients who underwent urinary diversion. MATERIALS AND METHODS: A retrospective study was conducted on patients with computed tomography-confirmed MUO between January 2016 and November 2020...
March 2024: Current Urology
https://read.qxmd.com/read/38486997/design-and-discovery-of-a-highly-potent-ultralong-acting-glp-1-and-glucagon-co-agonist-for-attenuating-renal-fibrosis
#4
JOURNAL ARTICLE
Qian Zhao, Jiale Dong, Han Liu, Hui Chen, Huan Yu, Shuyin Ye, Shuangjin Yu, Yu Li, Longhui Qiu, Nazi Song, Hongjiao Xu, Qi Liu, Zhiteng Luo, Yuyi Li, Rui Wang, Guodong Chen, Xianxing Jiang
The role of co-agonists of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) in chronic kidney disease (CKD) remains unclear. Herein we found that GLP-1R and GCGR expression levels were lower in the kidneys of mice with CKD compared to healthy mice and were correlated with disease severity. Interestingly, GLP-1R or GCGR knockdown aggravated the progression of kidney injury in both diabetic db/db mice and non-diabetic mice undergoing unilateral ureteral obstruction (UUO). Based on the importance of GLP-1R and GCGR in CKD, we reported a novel monomeric peptide, 1907-B, with dual-agonism on both GLP-1R and GCGR...
March 2024: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/38448513/interleukin-10-enhances-recruitment-of-immune-cells-in-the-neonatal-mouse-model-of-obstructive-nephropathy
#5
JOURNAL ARTICLE
Maja Wyczanska, Franziska Thalmeier, Ursula Keller, Richard Klaus, Hamsa Narasimhan, Xingqi Ji, Barbara U Schraml, Lou M Wackerbarth, Bärbel Lange-Sperandio
Urinary tract obstruction during renal development leads to inflammation, leukocyte infiltration, tubular cell death, and interstitial fibrosis. Interleukin-10 (IL-10) is an anti-inflammatory cytokine, produced mainly by monocytes/macrophages and regulatory T-cells. IL-10 inhibits innate and adaptive immune responses. IL-10 has a protective role in the adult model of obstructive uropathy. However, its role in neonatal obstructive uropathy is still unclear which led us to study the role of IL-10 in neonatal mice with unilateral ureteral obstruction (UUO)...
March 6, 2024: Scientific Reports
https://read.qxmd.com/read/38426107/urinary-mir-185-5p-is-a-biomarker-of-renal-tubulointerstitial-fibrosis-in-iga-nephropathy
#6
JOURNAL ARTICLE
Zhi-Yu Duan, Ru Bu, Shuang Liang, Xi-Zhao Chen, Chun Zhang, Qiu-Yue Zhang, Ji-Jun Li, Xiang-Mei Chen, Guang-Yan Cai
BACKGROUND: For IgA nephropathy (IgAN), tubular atrophy/interstitial fibrosis is the most important prognostic pathological indicator in the mesangial and endocapillary hypercellularity, segmental sclerosis, interstitial fibrosis/tubular atrophy, and presence of crescents (MEST-C) score. The identification of non-invasive biomarkers for tubular atrophy/interstitial fibrosis would aid clinical monitoring of IgAN progression and improve patient prognosis. METHODS: The study included 188 patients with primary IgAN in separate confirmation and validation cohorts...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38414138/retraction-gq5-hinders-renal-fibrosis-in-obstructive-nephropathy-by-selectively-inhibiting-tgf-%C3%AE-induced-smad3-phosphorylation
#7
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
February 28, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38410685/management-of-de-novo-nephrolithiasis-after-kidney-transplantation-a-comprehensive-review-from-the-european-renal-association-ckd-mbd-working-group
#8
REVIEW
Mehmet Kanbay, Sidar Copur, Cicek N Bakir, Alper Hatipoglu, Smeeta Sinha, Mathias Haarhaus
The lifetime incidence of kidney stones is 6%-12% in the general population. Nephrolithiasis is a known cause of acute and chronic kidney injury, mediated via obstructive uropathy or crystal-induced nephropathy, and several modifiable and non-modifiable genetic and lifestyle causes have been described. Evidence for epidemiology and management of nephrolithiasis after kidney transplantation is limited by a low number of publications, small study sizes and short observational periods. Denervation of the kidney and ureter graft greatly reduces symptomatology of kidney stones in transplant recipients, which may contribute to a considerable underdiagnosis...
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38395410/the-role-of-desmoglein-2-in-kidney-disease
#9
JOURNAL ARTICLE
Tong Xu, Lea Herkens, Ting Jia, Barbara M Klinkhammer, Sebastian Kant, Claudia A Krusche, Eva M Buhl, Sikander Hayat, Jürgen Floege, Pavel Strnad, Rafael Kramann, Sonja Djudjaj, Peter Boor
Desmosomes are multi-protein cell-cell adhesion structures supporting cell stability and mechanical stress resilience of tissues; best described in skin and heart. The kidney is exposed to various mechanical stimuli and stress, yet little is known about kidney desmosomes. In healthy kidneys, we found desmosomal proteins located at the apical-junctional complex in tubular epithelial cells. In four different animal models and patient biopsies with various kidney diseases, desmosomal components were significantly upregulated and partly miss-localized outside of the apical-junctional complexes along the whole lateral tubular epithelial cell membrane...
February 21, 2024: Kidney International
https://read.qxmd.com/read/38388151/bile-cast-nephropathy-after-sinusoidal-obstruction-syndrome
#10
Toshiki Terao, Kyosuke Horikawa, Ken-Ichi Matsuoka
No abstract text is available yet for this article.
March 2024: Kidney International
https://read.qxmd.com/read/38366861/delayed-treatment-with-erythropoietin-attenuates-renal-fibrosis-in-mouse-model-of-unilateral-ureteral-obstruction
#11
JOURNAL ARTICLE
Akihiro Nishida, Masashi Nishida, Tomoko Iehara
OBJECTIVES: Erythropoietin (EPO) exerts tissue-protective effects on various organs including the kidney. However, the effects of EPO on established renal fibrosis remain unclear. In this study, we aimed to examine the therapeutic potential of EPO against established renal fibrosis. METHODS: Renal fibrosis was induced in mice by unilateral ureteral obstruction (UUO) and the mice were treated with recombinant human EPO (rhEPO) daily during 7 and 13 days after UUO...
February 17, 2024: International Journal of Urology: Official Journal of the Japanese Urological Association
https://read.qxmd.com/read/38344714/lif-jak2-stat1-signaling-enhances-production-of-galactose-deficient-iga1-by-iga1-producing-cell-lines-derived-from-tonsils-of-patients-with-iga-nephropathy
#12
JOURNAL ARTICLE
Koshi Yamada, Zhi-Qiang Huang, Colin Reily, Todd J Green, Hitoshi Suzuki, Jan Novak, Yusuke Suzuki
INTRODUCTION: Galactose-deficient IgA1 (Gd-IgA1) plays a key role in the pathogenesis of IgA nephropathy (IgAN). Tonsillectomy has been beneficial to some patients with IgAN, possibly due to the removal of tonsillar cytokine-activated cells producing Gd-IgA1. To test this hypothesis, we used immortalized IgA1-producing cell lines derived from tonsils of patients with IgAN or obstructive sleep apnea (OSA) and assessed the effect of leukemia inhibitory factor (LIF) or oncostatin M (OSM) on Gd-IgA1 production...
February 2024: KI Reports
https://read.qxmd.com/read/38325670/jinchan-yishen-tongluo-formula-ameliorate-mitochondrial-dysfunction-and-apoptosis-in-diabetic-nephropathy-through-the-hif-1%C3%AE-pink1-parkin-pathway
#13
JOURNAL ARTICLE
Qiyan Zheng, Xueqin Zhang, Jing Guo, Yahui Wang, Yuhua Jiang, Shunmin Li, Yu Ning Liu, Wei Jing Liu
ETHNOPHARMACOLOGICAL RELEVANCE: The JinChan YiShen TongLuo (JCYSTL) formula, a traditional Chinese medicine (TCM), has been used clinically for decades to treat diabetic neuropathy (DN). TCM believes that the core pathogenesis of DN is "kidney deficiency and collateral obstruction," and JCYSTL has the effect of "tonifying kidney and clearing collateral," thus alleviating the damage to kidney structure and function caused by diabetes. From the perspective of modern medicine, mitochondrial damage is an important factor in DN pathogenesis...
February 5, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38318821/the-impact-of-obstructive-sleep-apnea-treatment-on-microvascular-complications-in-patients-with-type-2-diabetes-a-feasibility-randomized-controlled-trial
#14
JOURNAL ARTICLE
Esraa A Makhdom, Alisha Maher, Ryan Ottridge, Mathew Nicholls, Asad Ali, Brendan G Cooper, Ramzi A Ajjan, Srikanth Bellary, Wasim Hanif, Fahmy Hanna, David Hughes, Vijay Jayagopal, Rajni Mahto, Mayank Patel, James Young, Ananth U Nayak, Mimi Z Chen, Julie Kyaw-Tun, Susana Gonzalez, Ravikanth Gouni, Anuradhaa Subramanian, Nicola Adderley, Smitaa Patel, Abd A Tahrani
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is associated with an increased risk of diabetes-related complications. Hence, it is plausible that Continuous Positive Airway Pressure (CPAP) could have a favorable impact on these complications. To assess the feasibility of conducting a randomized control trial (RCT) in patients with type 2 diabetes (T2D) and OSA over 2 years. METHODS: An open-label multicenter feasibility RCT of CPAP vs no CPAP in patients with T2D and OSA...
February 6, 2024: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://read.qxmd.com/read/38297163/targeting-the-m-6-a-rna-methyltransferase-mettl3-attenuates-the-development-of-kidney-fibrosis
#15
JOURNAL ARTICLE
Hae Rim Jung, Jeonghwan Lee, Seung-Pyo Hong, Nayeon Shin, Ara Cho, Dong-Jin Shin, Jin Woo Choi, Jong-Il Kim, Jung Pyo Lee, Sung-Yup Cho
Kidney fibrosis is a major mechanism underlying chronic kidney disease (CKD). N6 -methyladenosine (m6 A) RNA methylation is associated with organ fibrosis. We investigated m6 A profile alterations and the inhibitory effect of RNA methylation in kidney fibrosis in vitro (TGF-β-treated HK-2 cells) and in vivo (unilateral ureteral obstruction [UUO] mouse model). METTL3-mediated signaling was inhibited using siRNA in vitro or the METTL3-specific inhibitor STM2457 in vivo and in vitro. In HK-2 cells, METTL3 protein levels increased in a dose- and time-dependent manner along with an increase in the cellular m6 A levels...
February 1, 2024: Experimental & Molecular Medicine
https://read.qxmd.com/read/38255158/adiponectin-c1q-tumor-necrosis-factor-related-protein-13-ctrp13-protects-against-renal-inflammation-and-fibrosis-in-obstructive-nephropathy
#16
JOURNAL ARTICLE
Yongxia Li, Wenzhe Wang, Changxuan Liu, Min Zeng, Li Xu, Rong Du, Cheng Wang
Renal inflammation and fibrosis are the important pathological phenomena associated with obstructive nephropathy. However, the underlying mechanism associated with this disease has yet to be fully elucidated. The present study, therefore, aimed to investigate the effects mediated by C1q/tumor necrosis factor-related protein 13 (CTRP13) on renal inflammation and fibrosis in addition to elucidating the underlying mechanism. To meet this aim, a mouse unilateral ureteral obstruction (UUO)-mediated renal dysfunction model was established...
December 25, 2023: Biomedicines
https://read.qxmd.com/read/38246802/igg4-related-kidney-disease-clinicopathologic-features-differential-diagnosis-and-mimics
#17
REVIEW
Sarwat I Gilani, Alessia Buglioni, Lynn D Cornell
IgG4-related kidney disease (IgG4-RKD) encompasses all forms of kidney disease that are part of IgG4-related disease (IgG4-RD). First recognized as IgG4-related tubulointerstitial nephritis (IgG4-TIN), and then IgG4-related membranous glomerulonephritis (IgG4-MGN), we now recognize additional patterns of interstitial nephritis, glomerular disease, and vascular disease that can be seen as part of IgG4-RKD. The clinical presentation is variable and can include acute or chronic kidney injury, proteinuria or nephrotic syndrome, mass lesion(s), and obstruction...
December 20, 2023: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38239308/right-sided-iliac-vein-compression-syndrome-when-the-vein-is-compressed-between-the-internal-and-external-iliac-arteries-a-case-report
#18
Tetsuo Yamanaka, Tatsuhiko Ishihara, Toru Hara, Yoshimaro Ichinohe, Toru Fukatsu
BACKGROUND: In its normal anatomical relationship, the inferior vena cava is located on the right side of the abdominal aorta. Iliac vein compression syndrome (IVCS) is a pathological condition in which a blood clot is formed due to blood flow obstruction when the left common iliac vein is compressed between the right common iliac artery and the vertebral body. Therefore, right-sided IVCS (RIVCS) is rare. The effectiveness of treatment for RIVCS has not been sufficiently investigated...
January 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38214881/reno-protective-effect-of-protocatechuic-acid-is-independent-of-sex-related-differences-in-murine-model-of-uuo-induced-kidney-injury
#19
JOURNAL ARTICLE
Karim M Saad, Évila Lopes Salles, Sahar Emami Naeini, Babak Baban, Marwa E Abdelmageed, Rania R Abdelaziz, Ghada M Suddek, Ahmed A Elmarakby
BACKGROUND: Obstructive nephropathy is a condition often caused by urinary tract obstruction either anatomical (e.g., tumors), mechanical (e.g., urolithiasis), or compression (e.g., pregnancy) and can progress to chronic kidney disease (CKD). Studies have shown sexual dimorphism in CKD, where males were found to have a more rapid decline in kidney function following kidney injury compared to age-matched females. Protocatechuic acid (PCA), an anti-oxidant and anti-inflammatory polyphenolic compound, has demonstrated promising effects in mitigating drug-induced kidney injuries...
January 12, 2024: Pharmacological Reports: PR
https://read.qxmd.com/read/38201227/nlrx1-prevents-m2-macrophage-polarization-and-excessive-renal-fibrosis-in-chronic-obstructive-nephropathy
#20
JOURNAL ARTICLE
Ye Liu, Lotte Kors, Loes M Butter, Geurt Stokman, Nike Claessen, Coert J Zuurbier, Stephen E Girardin, Jaklien C Leemans, Sandrine Florquin, Alessandra Tammaro
BACKGROUND: Chronic kidney disease often leads to kidney dysfunction due to renal fibrosis, regardless of the initial cause of kidney damage. Macrophages are crucial players in the progression of renal fibrosis as they stimulate inflammation, activate fibroblasts, and contribute to extracellular matrix deposition, influenced by their metabolic state. Nucleotide-binding domain and LRR-containing protein X (NLRX1) is an innate immune receptor independent of inflammasomes and is found in mitochondria, and it plays a role in immune responses and cell metabolism...
December 21, 2023: Cells
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