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https://www.readbyqxmd.com/read/28339567/role-of-biomechanical-forces-in-hyperfiltration-mediated-glomerular-injury-in-congenital-anomalies-of-the-kidney-and-urinary-tract
#1
Tarak Srivastava, Ganesh Thiagarajan, Uri S Alon, Ram Sharma, Ashraf El-Meanawy, Ellen T McCarthy, Virginia J Savin, Mukut Sharma
Congenital anomalies of the kidney and urinary tract (CAKUT) including solitary kidney constitute the main cause of progressive chronic kidney disease (CKD) in children. Children born with CAKUT develop signs of CKD only during adolescence and do not respond to renin-angiotensin-aldosterone system blockers. Early cellular changes underlying CKD progression to end-stage renal disease by early adulthood are not well understood. The mechanism of maladaptive hyperfiltration that occurs from loss of functional nephrons, including solitary kidney, is not clear...
January 17, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28320755/ciliary-mechanisms-of-cyst-formation-in-polycystic-kidney-disease
#2
Ming Ma, Anna-Rachel Gallagher, Stefan Somlo
Autosomal-dominant polycystic kidney disease (ADPKD) is a disease of defective tissue homeostasis resulting in active remodeling of nephrons and bile ducts to form fluid-filled sacs called cysts. The causal genes PKD1 and PKD2 encode transmembrane proteins polycystin 1 (PC1) and polycystin 2 (PC2), respectively. Together, the polycystins localize to the solitary primary cilium that protrudes from the apical surface of most kidney tubule cells and is thought to function as a privileged compartment that the cell uses for signal integration of sensory inputs...
March 20, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28292994/-a-recurrent-case-of-thymic-adenocarcinoma-effectively-treated-with-s-1-over-a-long-term-period
#3
Munehisa Takata, Isao Matsumoto, Yusuke Tanaka, Daisuke Saito, Shuhei Yoshida, Seiichi Kakegawa, Masaya Tamura, Hirofumi Takemura, Hiroko Ikeda
A 61-year-old woman with an abnormal radiograph shadow in her anterior mediastinum was admitted to our hospital and underwent an extended thymectomy. The pathological diagnosis of the tumor was a non-papillary adenocarcinoma of the thymus in pathological stage IV b using the Masaoka classification owing to mediastinal lymph node metastasis. We found parasternal lymph node metastases 5 months after her first operation, and subsequently, she underwent surgery and adjuvant radiotherapy. We found systemic lymph node metastases and metastatic lesions in distant organs, including her lungs, brain, and kidney 27 months after her first operation...
March 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28292209/risks-and-benefits-of-postoperative-double-j-stent-placement-after-ureteroscopy-urs-results-from-the-clinical-research-office-of-endourological-society-urs-global-study
#4
Ahmet Yaser Muslumanoglu, Sven Fuglsig, Antonio Frattini, Gaston Labate, Robert B Nadler, Alexey Martov, Carson Wong, Jean J M C H de la Rosette
PURPOSE: Double-J stent placement following stone removal by URS is common and recommended in many cases but debatable in others. In this study the risks and benefits of postoperative double-J stent placement in URS stone treatment procedures undertaken in current clinical practice, are examined. MATERIALS AND METHODS: The CROES URS is a prospective, observational, international, multicentre study in which patients who were candidates for URS as primary treatment or after failure of prior treatment for ureteral stones and renal stones...
March 14, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28280700/allograft-loss-from-acute-page-kidney-secondary-to-trauma-after-kidney-transplantation
#5
Kazuhiro Takahashi, Rohini Prashar, Krishna G Putchakayala, William J Kane, Jason E Denny, Dean Y Kim, Lauren E Malinzak
We report a rare case of allograft loss from acute Page kidney secondary to trauma that occurred 12 years after kidney transplantation. A 67-year-old Caucasian male with a past surgical history of kidney transplant presented to the emergency department at a local hospital with left lower abdominal tenderness. He recalled that his cat, which weighs 15 lbs, jumped on his abdomen 7 d prior. On physical examination, a small tender mass was noticed at the incisional site of the kidney transplant. He was producing a normal amount of urine without hematuria...
February 24, 2017: World Journal of Transplantation
https://www.readbyqxmd.com/read/28262263/renal-function-is-similar-in-solitary-kidneys-from-patients-with-and-without-diabetes
#6
Cristina Gluhovschi, Gheorghe Gluhovschi, Florica Gadalean, Silvia Velciov, Ligia Petrica, Bogdan Timar, Adriana Kaycsa, Romulus Timar
OBJECTIVES: Due to the shortage of living kidney donors and the current diabetes mellitus (DM) pandemic, studying the association of solitary kidney (SK) with DM is of paramount importance. Our aim was to assess the significance of the association between SK and DM. MATERIALS AND METHODS: Eighty-four patients with SK and DM (group A), with a mean age of 62.46±12.72 years, of whom 36 were males and 48 were females, were enrolled in the study. The control group (group B) comprised 84 SK patients without DM of similar age and duration of existence of a SK...
March 2, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28251485/endoscopic-treatment-of-upper-tract-urothelial-carcinoma
#7
REVIEW
Daniel P Verges, Costas D Lallas, Scott G Hubosky, Demetrius H Bagley
PURPOSE OF REVIEW: This study aims to make the reader be aware of recent trends regarding the endoscopic management of upper tract urothelial carcinoma (UTUC) via review of the urologic literature over the past 5 years. Given the rare incidence of this disease, and the lack of level 1 evidence, systematic reviews and meta-analyses were also evaluated. Studies of importance are also considered and outlined in the annotated reference section. RECENT FINDINGS: The PubMed database was queried using the following medical subject headings (MeSH terms): "carcinoma, transitional cell," "ureter," "ureteral neoplasms," "kidney pelvis," "endoscopy," "laser therapy," "ureteroscopy," "urologic surgical procedures," and "ureteroscopes...
April 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28248821/metastasis-to-the-lung-from-carcinomas-of-nonpulmonary-sites-after-prolonged-disease-free-intervals
#8
Sanjay Mukhopadhyay, Pradnya D Patil, Andres A Roma
Most carcinomas of nonpulmonary sites that metastasize to the lung do so within 5 years of diagnosis. Although examples of late metastasis to the lung after prolonged disease-free intervals (>5 y) have been reported sporadically, this phenomenon has not been systematically analyzed. The aim of this study was to describe the clinical and pathologic features of metastases to the lung from carcinomas of nonpulmonary origin after prolonged disease-free intervals. We searched our pathology archives to identify lung biopsies/resections containing metastases from carcinomas of nonpulmonary origin...
February 28, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28248052/-endoscopic-removal-of-papillary-tumors-of-upper-urinary-tract
#9
G N Akopyan, Yu G Alyaev, A Z Vinarov, L M Rapoport, M A Gazimiev, D G Tsarichenko, E V Shpot, N I Sorokin, A M Dymov, A M Pshikhachev, V Yu Lekarev, G S Akopyan
AIM: To assess the results of organ-sparing endoscopic treatment of patients with tumors of the upper urinary tract (UUT). MATERIALS AND METHODS: Twenty four patients underwent percutaneous and ureteropyeloscopic interventions for tumors of the upper urinary tract and were followed up at the Urology Clinic, I.M. Sechenov First MSMU. Retrograde removal of benign tumors of the renal pelvis and ureter (tumors sized from 5 to 35 mm), percutaneous removal of papillary carcinoma of renal pelvis of a solitary kidney, percutaneous removal of papillary carcinoma of renal pelvis of only one functioning kidney and percutaneous removal of papillary carcinoma of the lower calyx of the L-shaped kidney were performed in 21, 1, 1 and 1 patients, respectively...
December 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28248023/-pyeloureteral-stenting-using-nitinol-stents
#10
B G Guliev, A M Zagazezhev
AIM: To test the effectiveness of nitinol stents in restoring patency of pyeloureteral segment (PUS). MATERIALS AND METHODS: Endoureteral nitinol stents were used in 54 patients. The indications for stenting were recurrent strictures of upper urinary tract and ureteral tumor obstruction in 34 and 20 patients, respectively. In 9 (16.6%) of them, including 4 women and 5 men aged 28-65 years, stenting was performed for extensive recurrent PUS strictures. In 8 patients extensive strictures resulted from various surgical interventions on the PUS...
November 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28237299/imaging-appearances-at-follow-up-after-image-guided-solid-organ-abdominal-tumour-ablation
#11
REVIEW
N Patel, A J King, D J Breen
The role of minimally invasive, locoregional therapies in cancer is increasingly driven by the detection of small asymptomatic disease either incidentally or under surveillance for a known primary malignancy. Percutaneous image-guided ablation has become established as a parenchyma-sparing tool in the management of small volume primary and metastatic disease in the liver as well as solitary renal masses. As ablation is non-extirpative, post-ablation imaging is critical for the assessment of treatment completion, recurrence, and complications...
February 22, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28237283/ablative-therapies-for-renal-tumors-patient-selection-treatment-planning-and-follow-up
#12
Jean-Michel Correas, Christophe Delavaud, Jules Gregory, Thomas Le Guilchet, Lionel Lamhaut, Marc-Olivier Timsit, Arnaud Méjean, Olivier Hélénon
The increased use of abdominal imaging has led to a major increase in small renal tumors incidence particularly in the elderly population. Their management is evolving with the development of percutaneous ablation, particularly radiofrequency ablation, cryoablation, and microwave ablation. The typical indications that must be validated by a multidisciplinary committee include solid tumors less than 3cm in patients with multiple comorbidity factors (including age), contraindications to surgery, hereditary renal cancer, bilateral renal tumors, solitary kidney, pre-existing chronic kidney disease, or at high risk of predialysis renal function after partial nephrectomy...
February 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/28216928/spontaneous-forniceal-rupture-can-it-be-treated-conservatively
#13
Ahmed Gaber Al-Mujalhem, Mohammed Sayed Ahmed Aziz, Mohammed Farag Sultan, Ahmed Mohammed Al-Maghraby, Mohammed Abdelmonem Al-Shazly
CONTEXT: Spontaneous forniceal rupture is one of the possible complications of urolithiasis. The mechanism of forniceal rupture is not well explained in the literature. Most of the cases presented with sudden onset of acute renal colic and diagnosed by noncontrast CT (NCCT). Until now there is no solid consensus about the ideal management of such a condition. AIM: To study indications and validity of conservative management of spontaneous caliceal rupture. SETTINGS AND DESIGN: This is an observational prospective study...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28197034/laparoscopic-gastrocystoplasty-for-tuberculous-contracted-bladder
#14
Manickam Ramalingam, Kallappan Senthil, T S Balashanmugam
The stomach is the preferred augmentation option for a contracted bladder in a patient with renal failure. A 49-year-old female presented with right solitary functioning kidney with tuberculous lower ureteric stricture and contracted bladder. Her creatinine was 2.8 mg%. By laparoscopic approach, right gastroepiploic artery based gastric flap was isolated using staplers and used for augmentation and ureteric replacement. At 6-month follow-up, her creatinine was 1.9 mg%, and bladder capacity was 250 ml. She had mild hematuria, which settled with proton pump inhibitors...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28168075/metastatic-renal-cell-carcinoma-presenting-as-a-paranasal-sinus-mass-the-importance-of-differential-diagnosis
#15
Massimo Ralli, Giancarlo Altissimi, Rosaria Turchetta, Mario Rigante
Metastases in the paranasal sinuses are rare; renal cell carcinoma is the most common cancer that metastasizes to this region. We present the case of a patient with a 4-month history of a rapidly growing mass of the nasal pyramid following a nasal trauma, associated with spontaneous epistaxis and multiple episodes of hematuria. Cranial CT scan and MRI showed an ethmoid mass extending to the choanal region, the right orbit, and the right frontal sinus with an initial intracranial extension. Patient underwent surgery with a trans-sinusal frontal approach using a bicoronal incision combined with an anterior midfacial degloving; histological exam was compatible with a metastasis of clear cell renal cell carcinoma...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28161315/renal-development-in-the-fetus-and-premature-infant
#16
REVIEW
Stacy Rosenblum, Abhijeet Pal, Kimberly Reidy
Congenital abnormalities of the kidney and urinary tract (CAKUT) are one of the leading congenital defects to be identified on prenatal ultrasound. CAKUT represent a broad spectrum of abnormalities, from transient hydronephrosis to severe bilateral renal agenesis. CAKUT are a major contributor to chronic and end stage kidney disease (CKD/ESKD) in children. Prenatal imaging is useful to identify CAKUT, but will not detect all defects. Both genetic abnormalities and the fetal environment contribute to CAKUT. Monogenic gene mutations identified in human CAKUT have advanced our understanding of molecular mechanisms of renal development...
February 1, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28146462/first%C3%A2-in%C3%A2-man-experience-with-renal-denervation-of-multiple-renal-arteries-in-a-patient-with-solitary-kidney-and-resistant-hypertension
#17
Olga Możeńska, Marek Rosiak, Aneta Gziut, Robert J Gil, Dariusz A Kosior
No abstract text is available yet for this article.
January 31, 2017: Pol Arch Intern Med
https://www.readbyqxmd.com/read/28128905/open-partial-nephrectomy-for-entirely-intraparenchymal-tumors-a-matched-case-control-study-of-oncologic-outcome-and-complication-rate
#18
Piotr Zapala, Bartosz Dybowski, Nina Miazek, Piotr Radziszewski
PURPOSE: To compare the oncologic and clinical outcomes for open partial nephrectomy (OPN) performed in patients with entirely intraparenchymal tumors versus casematched controls, with exophytic lesions. MATERIAL AND METHODS: Patients having undergone OPN between 2007 and 2012 were investigated. Exclusion criteria included patients with a benign tumor, advanced malignancy, malignancies other than renal cell carcinoma, end-stage renal failure, or 3 or more co-existing chronic diseases...
March 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28127181/non-surgical-ablative-therapy-for-management-of-small-renal-masses-current-status-and-future-trends
#19
REVIEW
K Farrag, S Sriprasad
A large number of small renal masses (SRMs) with size less than 4 cm are being identified due to advances in diagnostic imaging. As the natural history of these tumours remains unknown, there is no reliable way to predict their behaviour or future growth. Although, partial nephrectomy is the gold standard for treatment of these tumours, ablative non-surgical therapies such as cryoablation and radiofrequency ablation provide a less invasive option of treatment with comparable oncological outcomes. In this systematic review, the principle, indications, methods of treatment, oncological control, complication and renal function of ablative therapies are critically reviewed...
March 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28108282/hyperfiltration-associated-biomechanical-forces-in-glomerular-injury-and-response-potential-role-for-eicosanoids
#20
REVIEW
Mukut Sharma, Ram Sharma, Ellen T McCarthy, Virginia J Savin, Tarak Srivastava
Hyperfiltration is a well-known risk factor in progressive loss of renal function in chronic kidney disease (CKD) secondary to various diseases. A reduced number of functional nephrons due to congenital or acquired cause(s) results in hyperfiltration in the remnant kidney. Hyperfiltration-associated increase in biomechanical forces, namely pressure-induced tensile stress and fluid flow-induced shear stress (FFSS) determine cellular injury and response. We believe the current treatment of CKD yields limited success because it largely attenuates pressure-induced tensile stress changes but not the effect of FFSS on podocytes...
January 17, 2017: Prostaglandins & Other Lipid Mediators
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