keyword
https://read.qxmd.com/read/38374078/long-term-trends-in-international-medical-electives-fees-a-database-mining-study
#21
JOURNAL ARTICLE
Kai Beckschulte, Ann-Kathrin Lederer, Maximilian Andreas Storz
BACKGROUND: Abroad medical electives are recognized as high-impact practice and considered a necessity to provide global health training. As of recently, the COVID-19 pandemic and its related travel restrictions prohibited most international elective activities. Another important barrier to abroad electives that received comparably little attention is elective and application fees, which - combined - may be as high as $5000 per month, and may prevent students with limited financial resources from applying for an international elective...
February 19, 2024: BMC Medical Education
https://read.qxmd.com/read/38333687/clinical-significance-of-type-iv-vascularization-of-laryngeal-lesions-according-to-the-ni-classification
#22
JOURNAL ARTICLE
Lucia Staníková, Peter Kántor, Katarína Fedorová, Karol Zeleník, Pavel Komínek
BACKGROUND: Scattered, small, dot-like intraepithelial papillary capillary loops (IPCLs) represent type IV epithelial vascularization according to "Ni classification" and are considered to be nonmalignant. According to the European Laryngological Society classification, these loops are malignant vascular changes. This contradiction has high clinical importance; therefore, clarification of the clinical significance of type IV vascularization according to the Ni classification is needed...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38327148/bowel-health-defecation-patterns-and-nutrient-intake-following-adoption-of-a-vegan-diet-a-randomized-controlled-trial
#23
RANDOMIZED CONTROLLED TRIAL
Julian Herter, Frieda Stübing, Volker Lüth, Julia Zimmermann, Ann-Kathrin Lederer, Luciana Hannibal, Roman Huber, Maximilian Andreas Storz
BACKGROUND: The beneficial effects of a plant-based diet on gut microbiota diversity are well documented, however, its impact on clinical bowel health and defecation patterns are less well understood. Vegetarian diets have been associated with a higher bowel movement (BM) frequency as well as softer stools in cross-sectional studies. The effects of the de-novo adoption of a vegan diet on bowel health, however, have never been investigated in a randomized-controlled trial. MATERIALS AND METHODS: The present study examined bowel health and defecation patterns in relation to diet and nutrient intake in a young and healthy sample of n  = 65 physically-active German university students who were randomly assigned to either a vegan or a meat-rich diet for eight weeks...
December 2024: Annals of Medicine
https://read.qxmd.com/read/38312823/transurethral-resection-of-bladder-tumor-a-systematic-review-of-simulator-based-training-courses-and-curricula
#24
REVIEW
Panagiotis Kallidonis, Angelis Peteinaris, Gernot Ortner, Kostantinos Pagonis, Costantinos Adamou, Athanasios Vagionis, Evangelos Liatsikos, Bhaskar Somani, Theodoros Tokas
OBJECTIVE: Transurethral resection of bladder tumor is one of the most common everyday urological procedures. This kind of surgery demands a set of skills that need training and experience. In this review, we aimed to investigate the current literature to find out if simulators, phantoms, and other training models could be used as a tool for teaching urologists. METHODS: A systematic review was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement and the recommendations of the European Association of Urology guidelines for conducting systematic reviews...
January 2024: Asian Journal of Urology
https://read.qxmd.com/read/38296109/hysteroscopic-metroplasty-using-holmium-yag-laser-for-treatment-of-septate-uterus
#25
JOURNAL ARTICLE
Anuja V Kulkarni, Vishvas M Kulkarni, Rameshwari Alahabade, Prachi D Ruikar, Rajashree Mahajan, Tejal Kulkarni, Dipti Giri, N Nandana
OBJECTIVE: To demonstrate the safety, efficacy, and ease of hysteroscopic metroplasty using Holmium YAG Laser for treatment of septate uterus. DESIGN: Stepwise demonstration of surgical technique with narrated video footage. SETTING: Septate uterus is the most common type of uterine anomaly. The incidence of uterine septum in women presenting with infertility and recurrent abortions is 15.4% (1)(2). Hysteroscopic septal incision is associated with improvement in live-birth rate in these women (3)...
January 29, 2024: Journal of Minimally Invasive Gynecology
https://read.qxmd.com/read/38260563/broadly-conserved-flgv-controls-flagellar-assembly-and-borrelia-burgdorferi-dissemination-in-mice
#26
Maxime Zamba-Campero, Daniel Soliman, Huaxin Yu, Amanda G Lasseter, Yuen-Yan Chang, Jun Liu, L Aravind, Mollie W Jewett, Gisela Storz, Philip P Adams
Flagella propel pathogens through their environments yet are expensive to synthesize and are immunogenic. Thus, complex hierarchical regulatory networks control flagellar gene expression. Spirochetes are highly motile bacteria, but peculiarly in the Lyme spirochete Borrelia burgdorferi , the archetypal flagellar regulator σ 28 is absent. We rediscovered gene bb0268 in B. burgdorferi as flgV, a broadly-conserved gene in the flagellar superoperon alongside σ 28 in many Spirochaetes, Firmicutes and other phyla, with distant homologs in Epsilonproteobacteria...
January 9, 2024: bioRxiv
https://read.qxmd.com/read/38244720/-use-of-indocyanine-green-to-evaluate-ovarian-perfusion-after-laparoscopic-detorsion-a-step-by-step-demonstration-video
#27
JOURNAL ARTICLE
Giovanni Di Lorenzo, Giuseppe Mirenda, Roberta Marie Gentile, Chiara Dal Pozzolo, De Santo Davide, Federico Romano, Giuseppe Ricci
OBJECTIVE: Demonstrate the usefulness of using indocyanine green after laparoscopic ovarian detorsion to save the ovary. DESIGN: A step-by-step video demonstration of a surgical technique. SETTING: Ovarian torsion is one of the most common gynecological emergencies, mainly affecting patients younger than 20 years of age [1], and causes 2% to 7% of acute abdomens [2]. It is not advisable to routinely perform ovariectomy even with a necrotic ovary appearance [1]...
January 18, 2024: Journal of Minimally Invasive Gynecology
https://read.qxmd.com/read/38243098/a-comparative-evaluation-of-fibreoptic-bronchoscopy-versus-c-mac-%C3%A2-d-blade-guided-videolaryngoscopy-for-nasotracheal-intubation-under-general-anesthesia-in-oropharyngeal-carcinoma-surgery-patients
#28
JOURNAL ARTICLE
Abhishek Kumar, Nishkarsh Gupta, Tanvi Bhargava, Anju Gupta, Vinod Kumar, Sachidanand Jee Bharti, Rakesh Garg, Seema Mishra, Sushma Bhatnagar, Rajeev K Malhotra
PURPOSE: Nasotracheal intubation (NTI) is required for surgery in oropharyngeal (OP) carcinoma patients, but it may be challenging because of distorted anatomy, mucosal congestion, and increased risk of bleeding. Flexible bronchoscopy (FB)-guided NTI is preferred in these cases but has limitations. In this randomized controlled study, we sought to compare C-MAC® D-BLADE-guided videolaryngoscopy (VL) (Karl Storz SE & Co. KG, Tuttlingen, Germany) with FB for NTI under general anesthesia in patients with OP carcinomas...
January 19, 2024: Canadian Journal of Anaesthesia
https://read.qxmd.com/read/38240384/efficacy-and-outcome-of-indocyanine-green-based-intraoperative-cholangiography-using-near-infrared-fluorescence-imaging-a-prospective-study
#29
JOURNAL ARTICLE
Anubhavv Gupta, Jaspal Singh, Atul Mishra, Sanjeev K Singla, Ravinder Pal Singh, Amandeep Singh Nar, Ashvind Bawa
INTRODUCTION: The most dreaded complication during laparoscopic cholecystectomy still remains to be injury to the common bile duct. The primary cause for bile duct injury during LC is misinterpretation of the biliary anatomy. Intra-operative cholangiography was introduced as a means of reducing the chances of biliary injury, done using Fluoroscopic imaging or Near-infrared fluorescence imaging method. NIRF is one of the most popular imaging methods in biomedical sciences. Indocyanine Green is sterile and water soluble which completely binds to albumin and is excreted in bile...
January 1, 2024: Journal of Minimal Access Surgery
https://read.qxmd.com/read/38222170/comparison-of-time-to-intubation-of-a-double-lumen-endobronchial-tube-utilizing-c-mac%C3%A2-versus-glidescope%C3%A2-versus-macintosh-blade-a-randomized-crossover-manikin-study
#30
JOURNAL ARTICLE
Srinivasan Rajagopal, Richard N Gardner, Elizabeth Swanson, Sung Kim, Rakesh Sondekoppam, Kenichi Ueda, Satoshi Hanada
BACKGROUND: Macintosh blade direct laryngoscopy is widely used for endotracheal intubation. It may, however, provide an incomplete view of the glottis in patients with challenging airway anatomy. Consequently, various video laryngoscopes have been developed to enhance the visualization of the glottis and facilitate intubation. Yet, the effectiveness of these video laryngoscopes for intubation using a double-lumen endotracheal tube (DLT), which is longer, larger, and more rigid and has a linear configuration as opposed to the naturally semicircular curvature of a single-lumen endotracheal tube, remains uncertain...
December 2023: Curēus
https://read.qxmd.com/read/38220555/comparison-of-single-incision-laparoscopic-percutaneous-and-cystoscope-forceps-assisted-morgagni-hernia-repair-techniques
#31
JOURNAL ARTICLE
Mehmet Hanifi Okur, Bahattin Aydoğdu, Mustafa Azizoğlu, Serkan Arslan, Salih Bayram, Erol Basuguy
OBJECTIVE: Our goal was to compare single-incision laparoscopic percutaneous and cystoscope forceps-assisted Morgagni hernia repair techniques. MATERIALS AND METHODS: A total of 40 patients were allocated to two groups, each with 20 patients. Group 1: Single incision (port) laparoscopic surgical percutaneous Morgagni hernia repair (with a 5 mm Storz laparoscopic scope entered through the umbilicus). Group 2: Single incision (port) laparoscopic surgical percutaneous Morgagni hernia repair (with an 11 Fr [3...
December 2, 2023: Journal of Pediatric Surgery
https://read.qxmd.com/read/38195998/genomic-structural-variation-is-associated-with-hypoxia-adaptation-in-high-altitude-zokors
#32
JOURNAL ARTICLE
Xuan An, Leyan Mao, Yinjia Wang, Qinqin Xu, Xi Liu, Shangzhe Zhang, Zhenglei Qiao, Bowen Li, Fang Li, Zhuoran Kuang, Na Wan, Xiaolong Liang, Qijiao Duan, Zhilong Feng, Xiaojie Yang, Sanyuan Liu, Eviatar Nevo, Jianquan Liu, Jay F Storz, Kexin Li
Zokors, an Asiatic group of subterranean rodents, originated in lowlands and colonized high-elevational zones following the uplift of the Qinghai-Tibet plateau about 3.6 million years ago. Zokors live at high elevation in subterranean burrows and experience hypobaric hypoxia, including both hypoxia (low oxygen concentration) and hypercapnia (elevated partial pressure of CO2 ). Here we report a genomic analysis of six zokor species (genus Eospalax) with different elevational ranges to identify structural variants (deletions and inversions) that may have contributed to high-elevation adaptation...
February 2024: Nature Ecology & Evolution
https://read.qxmd.com/read/38181979/the-crispr-cas-patent-files-part-2-is-cpf1-cas12a-a-less-conflict-prone-alternative-to-cas9
#33
REVIEW
Ulrich Storz
CRISPR Cpf1/Cas12a has been discussed as a less conflict prone alternative, patent-wise, to Cas9. This article investigates whether or not this assumption is correct, and comes to the conclusion that the promise that CRISPR Cpf1/Cas12 would make things easier, and be less conflict-prone, is fragile.
January 3, 2024: Journal of Biotechnology
https://read.qxmd.com/read/38107704/knee-lesions-with-anterior-cruciate-ligament-acl-tear-in-iraqi-adult-males-arthroscopic-findings
#34
JOURNAL ARTICLE
Iskandar Mahdi Alardi
This cross-sectional study aimed at exploring the frequency and extent of knee joint lesions associated with delayed treatment of anterior cruciate ligament (ACL) injury. It enrolled 300 patients from 2020 to 2022 who were subjected to arthroscopy for anterior cruciate ligament reconstruction. The sample was comprised of Iraqi adult male patients from different regions of Iraq, and the surgical procedure was carried out in Al-Diwaniyah Teaching Hospital. The findings were recorded by Karl Storz's camera system...
September 2023: Journal of Medicine and Life
https://read.qxmd.com/read/38071863/serum-levels-of-copper-but-not-zinc-are-associated-with-head-and-chest-cold-in-the-nhanes
#35
JOURNAL ARTICLE
Maximilian Andreas Storz, Alvaro Luis Ronco
BACKGROUND: Common colds are among the top reasons why children miss school and adults miss work. The Centers for Disease Control and prevention estimates that there are millions of cases of the common cold in the United States each year. The essential trace elements zinc and copper have immunomodulatory functions, and zinc has been reported to reduce the general risk of infection, whereas the copper-to-zinc ratio has been associated with an increased risk of incident infections in middle-aged men...
December 6, 2023: Journal of Trace Elements in Medicine and Biology
https://read.qxmd.com/read/38061566/protein-kinase-d1-a-targetable-mediator-of-pancreatic-cancer-development
#36
REVIEW
Alicia K Fleming Martinez, Peter Storz
Members of the Protein kinase D (PKD) kinase family each play important cell-specific roles in the regulation of normal pancreas functions. In pancreatic diseases PKD1 is the most widely characterized isoform with roles in pancreatitis and in induction of pancreatic cancer and its progression. PKD1 expression and activation increases in pancreatic acinar cells through macrophage secreted factors, Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling, and reactive oxygen species (ROS), driving the formation of precancerous lesions...
December 5, 2023: Biochimica et Biophysica Acta. Molecular Cell Research
https://read.qxmd.com/read/38031211/validation-study-of-ar-gynae-endotrainer-a-new-mobile-laparoscopic-simulator
#37
RANDOMIZED CONTROLLED TRIAL
A A Omar, E M Zon, M P Ismail, M Mahdi, A Ibrahim, E I Engku-Husna, N H Mohd Fauzi
INTRODUCTION: In gynaecology, laparoscopy is the choice of treatment for a lot of procedures as it is considered safe and effective. However, laparoscopic surgery requires skills that are different from those required for open surgery. In order to acquire the skills, a surgeon needs specific training. The aim of this study was to validate the AR Gynae endotrainer, a new mobile laparoscopic simulator, as a comparable box trainer for gynaecology laparoscopic training, comparing it with the well-established Karl Storz SZABO-BERCISACKIER laparoscopic trainer...
November 2023: Medical Journal of Malaysia
https://read.qxmd.com/read/38011569/an-acetyltranferase-moonlights-as-a-regulator-of-the-rna-binding-repertoire-of-the-rna-chaperone-hfq-in-escherichia-coli
#38
JOURNAL ARTICLE
Xing Luo, Aixia Zhang, Chin-Hsien Tai, Jiandong Chen, Nadim Majdalani, Gisela Storz, Susan Gottesman
Bacterial small RNAs (sRNAs) regulate gene expression by base-pairing with their target mRNAs. In Escherichia coli and many other bacteria, this process is dependent on the RNA chaperone Hfq, a mediator for sRNA-mRNA annealing. YhbS (renamed here as HqbA), a putative Gcn5-related N-acetyltransferase (GNAT), was previously identified as a silencer of sRNA signaling in a genomic library screen. Here, we studied how HqbA regulates sRNA signaling and investigated its physiological roles in modulating Hfq activity...
December 5, 2023: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/37996180/using-a-bougie-with-c-mac-video-laryngoscopy-did-not-improve-first-attempt-intubation-success-rates-in-critical-care-air-transport
#39
JOURNAL ARTICLE
Olivia Waldron, Rodney Sena, Susan Boehmer, Avram Flamm
OBJECTIVE: Studies have shown a bougie improves first-attempt success rates when used in combination with direct laryngoscopy during the initial attempt. The purpose of this study was to determine whether the use of a bougie in combination with C-MAC (Karl Storz, Tuttlingen, Germany) improves first-attempt success rates of endotracheal intubation (ETI) compared with C-MAC with a traditional stylet. METHODS: This study is a retrospective chart review using data collected on 371 intubations completed by a single air medical service using the C-MAC laryngoscope and either a bougie or a stylet...
2023: Air Medical Journal
https://read.qxmd.com/read/37984590/the-crispr-cas-patent-files-part-1-cas9-where-to-we-stand-at-the-10-year-halftime
#40
REVIEW
Ulrich Storz
CRISPR Cas9 has turned out to be one of the most influential technologies in the life sciences. However, ferocious patent debates and an unclear licensing situation makes access to this technology difficult for Small and medium enterprises. This article gives an overview of the status quo 10 years after the seminal patents were filed.
November 18, 2023: Journal of Biotechnology
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