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https://www.readbyqxmd.com/read/28541627/sentinel-lymph-node-mapping-with-indocyanine-green-in-vaginal-cancer
#1
In Ok Lee, Jung Yun Lee, Sunghoon Kim, Sang Wun Kim, Young Tae Kim, Eun Ji Nam
OBJECTIVE: Sentinel lymph node (SLN) mapping is being adapted to gynecologic cancer. Higher SLN mapping rates were reported with indocyanine green (ICG) compared to other dyes. The aim of this film is to share our experience of SLN mapping with ICG in vaginal cancer. METHODS: A 40 year-old woman was diagnosed with squamous cell vaginal cancer. About 1.5 cm-sized tumor was located on the posterior vaginal fornix. Preoperatively she was assumed to be stage I vaginal cancer...
July 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28528422/5-ala-fluorescence-guided-endoscopic-surgery-for-mixed-germ-cell-tumors
#2
Junichi Takeda, Masahiro Nonaka, Yi Li, Yumiko Komori, Takamasa Kamei, Ryoichi Iwata, Tetsuo Hashiba, Kunikazu Yoshimura, Akio Asai
5-Aminolevulinic acid (5-ALA) fluorescence-guided surgery is widely used for detection and planning of resection of malignant gliomas and other brain tumors. However, no reports have described 5-ALA fluorescence-guided surgery or direct visualization of germ cell tumors. Here, we report two cases of germ cell tumors in which a positive 5-ALA fluorescent signal was visualized with a neuroendoscope. Both cases had a tumor in the pineal region that was associated with hydrocephalus. The patients underwent surgery after administration of 5-ALA...
May 20, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28526471/-comparison-of-different-stylets-used-for-intubation-with-the-c-mac-d-blade-%C3%A2-videolaryngoscope-a-randomized-controlled-study
#3
Dilek Ömür, Başak Bayram, Şule Özbilgin, Volkan Hancı, Bahar Kuvaki
OBJECTIVE: The angle of the C-MAC D-Blade(®) videolaryngoscope, which is used for difficult airway interventions, is not compatible with routinely used endotracheal tubes. METHODS: A prospective randomized crossover study was performed comparing five intubation methods for use with standardized airways, including using different stylets or no stylet: Group HS, hockey-stick stylet; Group DS, D-blade type stylet; Group CS, CoPilot(®) videolaryngoscope rigid stylet(®); Group GEB, gum elastic bougie; and Group NS, no stylet...
May 17, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28520813/pancreatic-fat-content-by-magnetic-resonance-imaging-in-subjects-with-prediabetes-diabetes-and-controls-from-a-general-population-without-cardiovascular-disease
#4
Sophia D Heber, Holger Hetterich, Roberto Lorbeer, Christian Bayerl, Jürgen Machann, Sigrid Auweter, Corinna Storz, Christopher L Schlett, Konstantin Nikolaou, Maximilian Reiser, Annette Peters, Fabian Bamberg
BACKGROUND/OBJECTIVE: Despite the relevance of pancreatic fat content in the development of metabolic diseases, its association with impaired glucose metabolism, diabetes, and other adipose tissue compartments remains unclear. Thus, we determined differences in pancreatic fat content by magnetic resonance imaging (MRI) between subjects with prediabetes, diabetes, and normal controls in a cohort from the general population. METHODS: Subjects without history of cardiovascular disease with established diabetes or prediabetes as well as normal controls were included and underwent whole-body MRI on a 3T scanner...
2017: PloS One
https://www.readbyqxmd.com/read/28514653/the-presence-of-interleukin-13-at-pancreatic-adm-panin-lesions-alters-macrophage-populations-and-mediates-pancreatic-tumorigenesis
#5
Geou-Yarh Liou, Ligia Bastea, Alicia Fleming, Heike Döppler, Brandy H Edenfield, David W Dawson, Lizhi Zhang, Nabeel Bardeesy, Peter Storz
The contributions of the innate immune system to the development of pancreatic cancer are still ill defined. Inflammatory macrophages can initiate metaplasia of pancreatic acinar cells to a duct-like phenotype (acinar-to-ductal metaplasia [ADM]), which then gives rise to pancreatic intraepithelial neoplasia (PanIN) when oncogenic KRas is present. However, it remains unclear when and how this inflammatory macrophage population is replaced by tumor-promoting macrophages. Here, we demonstrate the presence of interleukin-13 (IL-13), which can convert inflammatory into Ym1+ alternatively activated macrophages, at ADM/PanIN lesions...
May 16, 2017: Cell Reports
https://www.readbyqxmd.com/read/28512220/increasing-intracellular-magnesium-levels-with-the-31-amino-acid-mgts-protein
#6
Hanbo Wang, Xuefeng Yin, Mona Wu Orr, Michael Dambach, Rebecca Curtis, Gisela Storz
Synthesis of the 31-amino acid, inner membrane protein MgtS (formerly denoted YneM) is induced by very low Mg(2+) in a PhoPQ-dependent manner in Escherichia coli Here we report that MgtS acts to increase intracellular Mg(2+) levels and maintain cell integrity upon Mg(2+) depletion. Upon development of a functional tagged derivative of MgtS, we found that MgtS interacts with MgtA to increase the levels of this P-type ATPase Mg(2+) transporter under Mg(2+)-limiting conditions. Correspondingly, the effects of MgtS upon Mg(2+) limitation are lost in a ∆mgtA mutant, and MgtA overexpression can suppress the ∆mgtS phenotype...
May 16, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28507660/severe-knee-pain-in-a-22-year-old-woman-after-trauma
#7
Maximilian Andreas Storz, Arne Oliver Lücke
No abstract text is available yet for this article.
March 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28478744/which-flexible-ureteroscopes-digital-vs-fiber-optic-can-easily-reach-the-difficult-lower-pole-calyces-and-have-better-end-tip-deflection-in-vitro-study-on-k-box-a-petra-evaluation
#8
Laurian Dragos, Bhaskar K Somani, Tarik Emre Sener, Salvatore Butticè, Silvia Proietti, Achilles Ploumidis, Catalin Iacoboaie, Steeve Doizi, Olivier Traxer
Background & purpose Modern flexible ureteroscopes (fURSs) have good deflection, but despite this, approaching an acute angled calyx can still be difficult. The goals of our in-vitro study were to assess the ability of the available modern fURSs to successfully access the sharp angled calyces and to compare the end-tip deflection of the various fiber-optic and digital fURSs. Materials & Methods Using a bench-training model for FURS (K-Box, Porgès-Coloplast), we tried to access an acute angled calyx with 9 different fURSs (BOA vision, COBRA vision, R...
May 6, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28470408/features-of-haptic-and-tactile-feedback-in-tors-a-comparison-of-available-surgical-systems
#9
Daniel T Friedrich, L Dürselen, B Mayer, S Hacker, F Schall, J Hahn, T K Hoffmann, P J Schuler, J Greve
Sustained interest and an increase of possible indications endorse the role of robot-assisted surgery of the head and neck region. However, broad clinical application is impeded by substantial extra cost, time exposure and a supposed deficit of haptic and tactile feedback. The role of haptic feedback has barely been examined in this context, and literature provides only limited objective validation. This point of criticism applies to all commercially available systems. We created an experimental setup to evaluate, quantify and compare the performance of surgical systems...
May 3, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28439193/hysteroscopic-management-of-uterine-arteriovenous-malformation
#10
Stefano Calzolari, Mauro Cozzolino, Eleonora Castellacci, Valeria Dubini, Alfonso Farruggia, Giovanni Sisti
BACKGROUND AND OBJECTIVES: Uterine arteriovenous malformation (AVM) is characterized by shunts between the myometrial arteries and veins. Treatment is based on the severity of uterine bleeding and ranges from conservative medical approaches to embolization of affected arteries. The aim of study was to evaluate the feasibility and safety of hysteroscopy for management of uterine AVM. METHODS: This was a retrospective study of a cohort of 11 cases occurring between March 2012 and December 2015 in our Regional Center of Excellence in Hysteroscopy, University of Florence...
April 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28428613/differential-regulation-of-pkd-isoforms-in-oxidative-stress-conditions-through-phosphorylation-of-a-conserved-tyr-in-the-p-1-loop
#11
Mathias Cobbaut, Rita Derua, Heike Döppler, Hua Jane Lou, Sandy Vandoninck, Peter Storz, Benjamin E Turk, Thomas Seufferlein, Etienne Waelkens, Veerle Janssens, Johan Van Lint
Protein kinases are essential molecules in life and their crucial function requires tight regulation. Many kinases are regulated via phosphorylation within their activation loop. This loop is embedded in the activation segment, which additionally contains the Mg(2+) binding loop and a P + 1 loop that is important in substrate binding. In this report, we identify Abl-mediated phosphorylation of a highly conserved Tyr residue in the P + 1 loop of protein kinase D2 (PKD2) during oxidative stress. Remarkably, we observed that the three human PKD isoforms display very different degrees of P + 1 loop Tyr phosphorylation and we identify one of the molecular determinants for this divergence...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428384/rewiring-metabolism-under-oxygen-deprivation
#12
Jay F Storz, Grant B McClelland
No abstract text is available yet for this article.
April 21, 2017: Science
https://www.readbyqxmd.com/read/28392950/diffuse-subcutaneous-emphysema-and-pneumomediastinum-secondary-to-a-minor-blunt-chest-trauma
#13
Maximilian Andreas Storz, Eric P Heymann, Aristomenis K Exadaktylos
Full medical evaluation is paramount for all trauma patients. Minor traumas are often overlooked, as they are thought to bear low injury potential. In this case report, we describe the case of a 48-year-old man presenting to our Emergency Department with mild to moderate right-sided shoulder and scapular pain following a fall from his own height ten days previously. Clinical and paraclinical investigations (CT) revealed diffuse right shoulder pain, with crepitations on palpation of the neck, right shoulder, and right lateral chest wall...
2017: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/28389019/evolution-in-visualization-for-sinus-and-skull-base-surgery-from-headlight-to-endoscope
#14
REVIEW
Omar H Ahmed, Sonya Marcus, Richard A Lebowitz, Joseph B Jacobs
Rhinoscopy became a formal field of study in the mid-nineteenth century as improvements in nasal specula were made and the potent vasoconstrictive effects of cocaine on the intranasal tissues were discovered. Since then, a multitude of advances in visualization and illumination have been made. The advent of the Storz-Hopkins endoscope in the mid-twentieth century represents a culmination of efforts spanning nearly 2 centuries, and illumination has evolved concomitantly. The future of endoscopic sinus surgery may integrate developing technologies, such as 3-dimensional endoscopy, augmented reality navigation systems, and robotic endoscope holders...
June 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28376420/three-dimensional-laparoscopy-for-living-donor-nephrectomy-with-vaginal-extraction-the-first-case
#15
Xavier Gamé, Mouath Binhazzaa, Michel Soulié, Nassim Kamar, Fédérico Sallusto
INTRODUCTION: Two-dimensional laparoscopy for living donor nephrectomy is the current standard of care. We report the first case of three-dimensional laparoscopy for living-donor nephrectomy with vaginal extraction. PRESENTATION OF CASE: The procedure was performed in a 66-year-old woman donating his left kidney to her son with the HD S 3D column (Karl Storz, Tuttlingen, Germany). Preoperative computed tomography showed one left renal artery. The warm ischemic time was 2min 20s and the operative time was 200min...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28370625/proq-fino-domain-proteins-another-ubiquitous-family-of-rna-matchmakers
#16
REVIEW
Mikolaj Olejniczak, Gisela Storz
Small RNAs (sRNAs), particularly those that act by limited base pairing with mRNAs, are part of most regulatory networks in bacteria. In many cases, the base-pairing interaction is facilitated by the RNA chaperone Hfq. However, not all bacteria encode Hfq and some base-pairing sRNAs do not require Hfq raising the possibility of other RNA chaperones. Candidates are proteins with homology to FinO, a factor that promotes base pairing between the FinP antisense sRNA and the traJ mRNA to control F plasmid transfer...
March 30, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28362841/alteration-of-the-%C3%AE-1%C3%AE-2-%C3%AE-2%C3%AE-1-subunit-interface-contributes-to-the-increased-hemoglobin-oxygen-affinity-of-high-altitude-deer-mice
#17
Noriko Inoguchi, Nobuhiro Mizuno, Seiki Baba, Takashi Kumasaka, Chandrasekhar Natarajan, Jay F Storz, Hideaki Moriyama
BACKGROUND: Deer mice (Peromyscus maniculatus) that are native to high altitudes in the Rocky Mountains have evolved hemoglobins with an increased oxygen-binding affinity relative to those of lowland conspecifics. To elucidate the molecular mechanisms responsible for the evolved increase in hemoglobin-oxygen affinity, the crystal structure of the highland hemoglobin variant was solved and compared with the previously reported structure for the lowland variant. RESULTS: Highland hemoglobin yielded at least two crystal types, in which the longest axes were 507 and 230 Å...
2017: PloS One
https://www.readbyqxmd.com/read/28361035/mitochondrial-and-oxidative-stress-mediated-activation-of-protein-kinase-d1-and-its-importance-in-pancreatic-cancer
#18
REVIEW
Heike Döppler, Peter Storz
Due to alterations in their metabolic activity and decreased mitochondrial efficiency, cancer cells often show increased generation of reactive oxygen species (ROS), but at the same time, to avoid cytotoxic signaling and to facilitate tumorigenic signaling, have mechanism in place that keep ROS in check. This requires signaling molecules that convey increases in oxidative stress to signal to the nucleus to upregulate antioxidant genes. Protein kinase D1 (PKD1), the serine/threonine kinase, is one of these ROS sensors...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28358178/time-to-intubation-in-obese-patients-a-randomized-study-comparing-direct-laryngoscopy-and-videolaryngoscopy-in-experienced-anaesthetists
#19
Fredrik Ander, Anders Magnuson, Lars Berggren, Rebecca Ahlstrand, Alex de Leon
BACKGROUND: Airway management may be difficult in obese patients. Moreover, during prolonged intubation, oxygen desaturation develops rapidly. Videolaryngoscopy improves the view of the larynx, and the Storz® C-MACTM has been shown to be superior to other videolaryngoscopes in terms of intubation time in obese patients. However, no effort has been made to compare the Storz® C-MACTM with direct laryngoscopy. The aim of the study was to evaluate if the use of Storz® C-MACTM may reduce intubation time when compared to direct laryngoscopy (classic Macintosh® blade)...
March 28, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28338307/evaluation-of-the-spies%C3%A2-modalities-image-quality
#20
Esteban Emiliani, Michele Talso, Mohammed Baghdadi, Aarón Barreiro, Andrea Orosa, Pol Serviàn, Pavel Gavrilov, Silvia Proietti, Olivier Traxer
INTRODUCTION: The Spies™ system (Karl-Storz®) was introduced into digital ureteroscopy to improve endoscopic vision. To date, there is no data to either indicate which of the Spies modalities is better for improving diagnosis and treatment procedures, nor to compare the modalities in terms of image quality. The aim of this study was to evaluate and compare the image quality of five Spies™ modalities (SM) to the standard white light in an in-vitro model. MATERIALS AND METHODS: Two standardized grids and 3 stones of different composition were recorded in white light and the 5SM (Clara, Chroma, Clara+Chroma), Spectra A and B) using 4 standardized aqueous scenarios...
March 24, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
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