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https://www.readbyqxmd.com/read/28094826/response-to-dittrich-et-al-non-embryo-destructive-extraction-of-pluripotent-embryonic-stem-cells-overlooked-legal-prohibitions-professional-legal-consequences-and-inconsistencies-in-patent-law
#1
REVIEW
T Faltus, U Storz
The publication of "Non-embryo-destructive Extraction of Pluripotent Embryonic Stem Cells: Implications for Regenerative Medicine and Reproductive Medicine" by Dittrich et al. in Geburtshilfe und Frauenheilkunde 2015; 75: 1239-1242 1 describes various possibilities which could result from the non-embryo-destructive extraction of embryonic stem cells from human blastocysts. But implementing this method is more problematic, both legally and ethically, than the authors have represented it to be and is illegal in Germany...
December 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28077391/acclimation-to-hypoxia-increases-carbohydrate-use-during-exercise-in-high-altitude-deer-mice
#2
Daphne S Lau, Alex D Connaty, Sajeni Mahalingam, Nastashya Wall, Zachary A Cheviron, Jay F Storz, Graham R Scott, Grant B McClelland
The low oxygen experienced at high altitude is a significant challenge to effective aerobic locomotion, as it requires sustained tissue oxygen delivery in addition to the appropriate allocation of metabolic substrates. Here we test whether high- and low-altitude deer mice (Peromyscus maniculatus) have evolved different acclimation responses to hypoxia with respect to muscle metabolism and fuel use during submaximal exercise. Using F1-generation high- and low-altitude deer mice that were born and raised in common conditions, we assessed 1) fuel use during exercise, 2) metabolic enzyme activities, and 3) gene expression for key transporters and enzymes in the gastrocnemius...
January 11, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28073204/who-apparently-more-spends-in-reality-spends-less-spending-a-little-more-for-the-rental-of-the-extracorporeal-lithotripter-can-save-a-lot-about-the-days-of-hospitalization-for-urinary-stones
#3
Giuseppe Albino, Francesco Albergo
OBJECTIVE: The right to health (according to the Article 32 of the Italian Republic Constitution) is financially conditioned; for this reason the National Health System (NHS) has the objective of rationalize health expenditure according to the criteria of efficiency, effectiveness and economy. This paper is an example of rationalization concerning the extracorporeal shock wave lithotripsy (ESWL). MATERIALS AND METHODS: Hospital admissions for urinary stones were taken into account...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28067954/elemental-variability-in-the-coralline-alga-lithophyllum-yemenense-as-an-archive-of-past-climate-in-the-gulf-of-aden-nw-indian-ocean
#4
Annalisa Caragnano, Daniela Basso, David Storz, Dorrit E Jacob, Federica Ragazzola, Francesca Benzoni, Eric Dutrieux
This study presents the first algal thallus (skeleton) archive of Asian monsoon strength and Red Sea influence in the Gulf of Aden. Mg/Ca, Li/Ca, Ba/Ca were measured on Lithophyllum yemenense from Balhaf (Gulf of Aden) using Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS), and Mg/Ca ratio oscillation was used to reconstruct the chronology (34 years). Oscillations of element rates corresponding to the algal growth between 1974 and 2008 were compared with recorded climate and oceanographic variability...
January 9, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28011978/what-is-the-best-tool-for-transanal-endoscopic-microsurgery-tem-a-case-matched-study-in-74-patients-comparing-a-standard-platform-and-a-disposable-material
#5
Diane Mege, Valérie Bridoux, Léon Maggiori, Jean-Jacques Tuech, Yves Panis
PURPOSE: Transanal endoscopic microsurgery (TEM) is the gold standard for local excision of rectal lesions, but no study exists concerning the best material. The objective was to compare TEM using a disposable material vs a standard platform through a case-matched study. METHODS: Patients who underwent TEM for rectal neoplasms were identified from prospective databases in two tertiary referral centers and matched according to four criteria (sex, tumor location, size, distance from the anal verge): TEM using a disposable material (GelPoint Applied®; group A) and TEM using a standard TEO® platform (Karl Storz, Tuttlingen, Germany; group B)...
December 24, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28009138/intracorporeal-hybrid-single-port-vs-conventional-laparoscopic-appendectomy-in-children
#6
Paul Anthony Karam, Amy Hiuser, David Magnuson, Federico Gian Filippo Seifarth
Transumbilical laparoscopic assisted appendectomy combines laparoscopic single port dissection with open appendectomy after exteriorization of the appendix through the port site. Compared to the conventional three-port approach, this technique provides an alternative with excellent cosmetic outcome. We developed a safe and effective technique to perform an intracorporeal single port appendectomy, using the same laparoscope employed in the extracorporeal procedure. Retrospective review of 71 consecutively performed intracorporeal single port appendectomies and 30 conventional three-port appendectomies in children 6 to 17 years of age...
December 20, 2016: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
https://www.readbyqxmd.com/read/27981926/stone-free-rate-after-extracorporeal-shockwave-lithotripsy-in-the-management-of-pediatric-renal-stones-in-lower-pole-and-other-locations-a-comparative-study
#7
Nadeem Iqbal, Shujah Muhammad, Warda Zafar, Ravale Tashfeen, Javaria Faiz, Aisha Hasan, Ijaz Hussain, Saeed Akhter
OBJECTIVE: To determine a difference in the stone-free-rate among different renal locations in children after extracorporeal shockwave lithotripsy (ESWL). STUDY DESIGN: A descriptive study. PLACE AND DURATION OF STUDY: Urology Department, Shifa International Hospital, Islamabad, Pakistan, from January 2007 to June 2015. METHODOLOGY: The study included children who underwent ESWL, divided into three groups based on location of stones in kidney as group A (lower pole stones), group B (upper and mid pole stones) and group C (renal pelvis stone), respectively...
November 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27981862/evaluation-of-a-novel-single-use-flexible-ureteroscope
#8
Joanne Andrea Dale, Adam Geoffrey Kaplan, Daniela Radvak, Richard Shin, Anika Ackerman, Tony T Chen, Charles D Scales, Michael N Ferrandino, W Neal Simmons, Glenn M Preminger, Michael Eric Lipkin
INTRODUCTION: A novel single-use flexible ureteroscope promises the optical characteristics and maneuverability of a reusable 4th generation flexible ureteroscope. In this study, the LithoVue Single-Use Digital flexible ureteroscope was directly compared to contemporary reusable flexible ureteroscopes, with regards to optics, deflection and irrigation flow. METHODS: Three flexible ureteroscopes including the LithoVue (Single Use, Boston Scientific, USA), Flex-Xc (Karl Storz, Germany) and Cobra (Richard Wolf, Germany) were assessed in vitro for image resolution, distortion, color representation, grayscale imaging, field of view and depth of field...
December 16, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27976982/patent-eligibility-of-stem-cells-in-europe-where-do-we-stand-after-8-years-of-case-law
#9
Ulrich Storz, Timo Faltus
Since 2006, some of the highest ranking European Courts have issued decisions related to the patent eligibility of human embryonic stem cells. The question of patent eligibility of human embryonic stem cells remains, however, still erratic, at least in some aspects. This article will give a short comprehensive overview of the case history, and discuss questions still unsolved.
January 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/27943450/photobiomodulation-therapy-in-breast-cancer-related-lymphedema-a-randomized-placebo-controlled-trial
#10
Maximilian Andreas Storz, Benjamin Gronwald, Sven Gottschling, Jakob Schöpe, Russalina Mavrova, Sascha Baum
BACKGROUND: The aim of our study was to examine the effects of Photobiomodulation Therapy (PBMT) in the treatment of breast cancer-related lymphedema using a compactly designed treatment regime consisting of eight therapy sessions in combination with a cluster laser device covering a total area size of 78.54 cm² over the axillary. METHODS: 40 patients with unilateral lymphedema were enrolled in this double blind, placebo-controlled trial in order to evaluate effects of PBMT on lymphedema-related pain, quality of life, grip strength and limb volume difference...
December 10, 2016: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/27931702/peripheral-nerve-blocks-causing-increased-risk-for-fall-and-difficulty-in-ambulation-for-the-hip-and-knee-joint-replacement-patient
#11
Bonnie L Crumley Aybar, Michael J Gillespie, Sean F Gipson, Caitlin E Mullaney, Melissa Tommasino-Storz
A systematic review of the literature was completed by the Evidence-Based Practice Group for the Patient population, Intervention/Issue, Comparison Intervention, Outcomes, Timing (PICOT) question: "Does the use of a peripheral nerve block increase the risk for falls and difficulty ambulation in patients after lower extremity surgery through postoperative day 2?" A search of multiple databases using specified key terms resulted in 258 articles for total knee arthroplasty or total hip arthroplasty. These were reduced to 13 with exclusion criteria and became primary evidence...
December 2016: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/27926725/an-update-on-obtaining-and-enforcing-therapeutic-antibody-patent-claims
#12
Theresa Gresl, Ulrich Storz, Colin Sandercock
No abstract text is available yet for this article.
December 7, 2016: Nature Biotechnology
https://www.readbyqxmd.com/read/27890314/endoscopic-surgery-in-children-the-challenge-goes-on
#13
REVIEW
David C van der Zee
: Paediatric endoscopic surgery is greatly indebted to Karl Storz for developing paediatric endoscopic instruments. In more recent years, there is an increasing interest in endoscopic surgery in neonates. Now more complex procedures are being performed, although it will take another generation before these will be more generally applied. One of the key factors to success is training. More sophisticated training models are becoming available, allowing practicing in a safe environment before putting the procedure to practice...
February 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27870848/genetically-blocking-the-zebrafish-pineal-clock-affects-circadian-behavior
#14
Zohar Ben-Moshe Livne, Shahar Alon, Daniela Vallone, Yared Bayleyen, Adi Tovin, Inbal Shainer, Laura G Nisembaum, Idit Aviram, Sima Smadja-Storz, Michael Fuentes, Jack Falcón, Eli Eisenberg, David C Klein, Harold A Burgess, Nicholas S Foulkes, Yoav Gothilf
The master circadian clock in fish has been considered to reside in the pineal gland. This dogma is challenged, however, by the finding that most zebrafish tissues contain molecular clocks that are directly reset by light. To further examine the role of the pineal gland oscillator in the zebrafish circadian system, we generated a transgenic line in which the molecular clock is selectively blocked in the melatonin-producing cells of the pineal gland by a dominant-negative strategy. As a result, clock-controlled rhythms of melatonin production in the adult pineal gland were disrupted...
November 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27865900/detection-of-potentially-unnecessary-and-wasteful-clinical-trial-research-cumulative-meta-epidemiological-and-trial-sequential-analysis
#15
Philipp Storz-Pfennig
OBJECTIVE: The objective was to estimate the presence and extent to which potentially unnecessary and therefore maybe wasteful clinical trials regarding relevant interventions and outcomes in major clinical areas had been conducted. STUDY DESIGN AND METHODS: From current Cochrane collaboration systematic reviews in major medical fields (e.g. CVD, cancer, psychiatry) 13 different comparisons were sampled. A cumulative meta-analysis was conducted for each and trial sequential analysis applied to determine when in the course of evidence accrual evidence was found sufficient to reach a reliable conclusion...
November 16, 2016: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/27846568/predictable-convergence-in-hemoglobin-function-has-unpredictable-molecular-underpinnings
#16
Chandrasekhar Natarajan, Federico G Hoffmann, Roy E Weber, Angela Fago, Christopher C Witt, Jay F Storz
To investigate the predictability of genetic adaptation, we examined the molecular basis of convergence in hemoglobin function in comparisons involving 56 avian taxa that have contrasting altitudinal range limits. Convergent increases in hemoglobin-oxygen affinity were pervasive among high-altitude taxa, but few such changes were attributable to parallel amino acid substitutions at key residues. Thus, predictable changes in biochemical phenotype do not have a predictable molecular basis. Experiments involving resurrected ancestral proteins revealed that historical substitutions have context-dependent effects, indicating that possible adaptive solutions are contingent on prior history...
October 21, 2016: Science
https://www.readbyqxmd.com/read/27846167/application-of-fluorescent-cholangiography-for-determination-of-the-resection-line-during-a-single-incision-laparoscopic-cholecystectomy-for-a-benign-lesion-of-the-cystic-duct-preliminary-experience
#17
Motoi Nojiri, Tsuyoshi Igami, Hiroshi Tanaka, Yoshitaka Toyoda, Tomoki Ebata, Yukihiro Yokoyama, Gen Sugawara, Takashi Mizuno, Junpei Yamaguchi, Masato Nagino
BACKGROUND: To avoid bile leakage from the stump of a cystic duct that is closed at edematous and/or involved areas, the decision regarding the location of the resection line during a laparoscopic cholecystectomy for benign lesions extending into the cystic duct is important and requires technical ingenuity. For these situations, we used fluorescent cholangiography. METHODS: Our procedure for single-incision laparoscopic cholecystectomy utilized the SILS-Port, and an additional pair of 5-mm forceps was inserted via an umbilical incision...
December 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/27844237/intraoperative-near-infrared-autofluorescence-imaging-of-parathyroid-glands
#18
Roland Ladurner, Sandra Sommerey, Nora Al Arabi, Klaus K J Hallfeldt, Herbert Stepp, Julia K S Gallwas
OBJECTIVE: To identify parathyroid glands intraoperatively by exposing their autofluorescence using near-infrared light. METHODS: Fluorescence imaging was carried out during minimally invasive and open parathyroid and thyroid surgery. After identification, the parathyroid glands as well as the surrounding tissue were exposed to near-infrared (NIR) light with a wavelength of 690-770 nm using a modified Karl Storz near-infrared/indocyanine green (NIR/ICG) endoscopic system...
November 14, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27819651/endoscopic-assisted-cochlear-implantation-a-case-series
#19
Kadir Serkan Orhan, Beldan Polat, Mehmet Çelik, Şenol Çomoğlu, Yahya Güldiken
The aim of the present study was to describe the use of the endoscopic-assisted cochlear implantation in cases with an unsuccessful standard surgical technique because of not achieving adequate exposure to the round window (RW). Three patients with a bilateral profound hearing loss were operated using an endoscopic-assisted cochlear implant procedure at our tertiary university referral center between 2012 and 2014. In all of the patients, a retroauricular "c" shaped incision was performed and a subperiosteal pocket was created...
November 7, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27805769/basal-ganglia-dysfunction-in-complex-regional-pain-syndrome-a-valid-hypothesis
#20
REVIEW
M Azqueta-Gavaldon, H Schulte-Göcking, C Storz, S Azad, A Reiners, D Borsook, L Becerra, E Kraft
: Complex regional pain syndrome (CRPS) is a poorly understood pain disorder of the limbs. Maladaptive cortical plasticity has been shown to play a major role in its pathophysiological presentation. Recently, there is increasing interest in the role of the basal ganglia (BG), since clinical findings and neuroimaging studies point to possible BG involvement in CRPS. CRPS symptoms are often characterized by movement disorders associated with BG dysfunction. Very frequently, dystonia and tremor are reported and, to a lesser extent, myoclonus...
November 2, 2016: European Journal of Pain: EJP
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