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https://www.readbyqxmd.com/read/29662543/optical-improvements-in-the-diagnosis-of-bladder-cancer-implications-for-clinical-practice
#1
REVIEW
Tina Schubert, Steffen Rausch, Omar Fahmy, Georgios Gakis, Arnulf Stenzl
Background: For over 100 years white-light cystoscopy has remained the gold-standard technique for the detection of bladder cancer (BCa). Some limitations in the detection of flat lesions (CIS), the differentiation between inflammation and malignancy, the inaccurate determination of the tumor margin status as well as the tumor depth, have led to a variety of technological improvements. The aim of this review is to evaluate the impact of these improvements in the diagnosis of BCa and their effectiveness in clinical practice...
November 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29658780/inter-and-intraobserver-variability-of-an-anatomical-landmark-based-manual-segmentation-method-by-mri-for-the-assessment-of-skeletal-muscle-fat-content-and-area-in-subjects-from-the-general-population
#2
Lena Sophie Kiefer, Jana Fabian, Roberto Lorbeer, Jürgen Machann, Corinna Storz, Mareen Sarah Kraus, Elke Wintermeyer, Christopher L Schlett, Frank Roemer, Konstantin Nikolaou, Annette Peters, Fabian Bamberg
OBJECTIVES: Changes in skeletal muscle composition, such as fat content and mass, may exert unique metabolic and musculoskeletal risks; however, the reproducibility of their assessment is unknown. We determined the variability of the assessment of skeletal muscle fat content and area by magnetic resonance imaging (MRI) in a population-based sample. METHODS: A random sample from a prospective, community-based cohort study (KORA-FF4) was included. Skeletal muscle fat content was quantified as proton-density fat-fraction (PDFF) and area as cross-sectional area (CSA) in multi-echo Dixon sequences (TR 8...
April 16, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29628581/ease-of-intubation-with-c-mac-videolaryngoscope-use-of-60%C3%A2-angled-styletted-endotracheal-tube-versus-intubation-over-bougie
#3
Pulak Tosh, Sunil Rajan, Lakshmi Kumar
Background: Although videolaryngoscopes improve glottic visualization, their actual usefulness in intubation is not yet established. Aims: The primary objective was to compare the ease of oral intubation with the use of 60° angled styletted endotracheal tube versus that performed over bougie inserted under videolaryngoscopic guidance. The secondary objectives were assessment of incidence of airway loss, hemodynamic changes, and time and number of attempts at intubation...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29628570/effect-of-c-mac-video-laryngoscope-aided-intubations-using-d-blade-on-incidence-and-severity-of-postoperative-sore-throat
#4
Pulak Tosh, Dilesh Kadapamannil, Sunil Rajan, Naina Narayani, Lakshmi Kumar
Background: Video laryngoscope-aided intubations require less force to align oral, pharyngeal, and laryngeal planes to visualize the glottis opening during intubation. Aim: The primary objective of the study was to assess the incidence and severity of postoperative sore throat (POST) in patients who were intubated with C-MAC video laryngoscope using D-blade versus traditional Macintosh laryngoscope. Settings and Design: This prospective, randomized, open label study was conducted in a tertiary care institution...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29616907/a-practical-guide-for-physicians-and-health-care-workers-to-reduce-their-carbon-footprint-in-daily-clinical-work
#5
Maximilian Andreas Storz
With Earth Overshoot Day having recently passed, there is no space for complacency regarding taking care of our planet. On August 2, 2017, humanity used nature's resource budget for the entire year. For decades, we have lived far beyond our means by overexploiting natural resources and spewing pollution, such as microplastics and industrial chemicals, into our environment. On the other hand, public awareness of human-induced climate change has also increased since the 1980s. The frequent media coverage about extreme weather conditions and natural disasters, such as Hurricane Irma in 2017, serves as an important reminder that anthropogenic climate change is happening now...
March 12, 2018: Permanente Journal
https://www.readbyqxmd.com/read/29608560/molecular-basis-of-hemoglobin-adaptation-in-the-high-flying-bar-headed-goose
#6
Chandrasekhar Natarajan, Agnieszka Jendroszek, Amit Kumar, Roy E Weber, Jeremy R H Tame, Angela Fago, Jay F Storz
During the adaptive evolution of a particular trait, some selectively fixed mutations may be directly causative and others may be purely compensatory. The relative contribution of these two classes of mutation to adaptive phenotypic evolution depends on the form and prevalence of mutational pleiotropy. To investigate the nature of adaptive substitutions and their pleiotropic effects, we used a protein engineering approach to characterize the molecular basis of hemoglobin (Hb) adaptation in the high-flying bar-headed goose (Anser indicus), a hypoxia-tolerant species renowned for its trans-Himalayan migratory flights...
April 2, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29589051/-chemotherapy-induced-nausea-and-vomiting-current-recommendations-for-prophylaxis
#7
REVIEW
E Storz, J E Gschwend, M Retz
The chemotherapy-induced nausea and vomiting (CINV) is one of the most frequent side effects in cytostatic therapy and a profound challenge during the therapy of cancer patients. Therefore, standardized guideline-orientated prophylaxis is essential and a fundamental contribution for the success of treatment. This review summarizes the current recommendations for CINV of the Multinational Association of Supportive Care in Cancer (MASCC) and European Society of Medical Oncology (ESMO), the American Society for Clinical Oncology (ASCO), the National Comprehensive Cancer Network (NCCN) and the S3-guideline Supportive Therapie of the Leitlinienprogramm Onkologie and shall facilitate its use in the daily routine...
March 27, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29581920/first-clinical-applications-of-a-high-definition-three-dimensional-exoscope-in-pediatric-neurosurgery
#8
Thomas Beez, Christopher Munoz-Bendix, Kerim Beseoglu, Hans-Jakob Steiger, Sebastian A Ahmadi
The ideal visualization tools in microneurosurgery should provide magnification, illumination, wide fields of view, ergonomics, and unobstructed access to the surgical field. The operative microscope was the predominant innovation in modern neurosurgery. Recently, a high-definition three-dimensional (3D) exoscope was developed. We describe the first applications in pediatric neurosurgery. The VITOM 3D exoscope (Karl Storz GmbH, Tuttlingen, Germany) was used in pediatric microneurosurgical operations, along with an OPMI PENTERO operative microscope (Carl Zeiss AG, Jena, Germany)...
January 24, 2018: Curēus
https://www.readbyqxmd.com/read/29562765/comparison-of-flexible-ureterorenoscope-quality-of-vision-an-in-vitro-study
#9
Michele Talso, Silvia Proietti, Esteban Emiliani, Andrea Gallioli, Laurian Dragos, Andrea Orosa Andrada, Pol Servián, Aarón Barreiro, Guido Giusti, Emanuele Montanari, Bhaskar K Somani, Olivier Traxer
INTRODUCTION Flexible Ureterorenoscopy (fURS) is one of the best solution for treatment of renal calculi less than 2 cm and for upper tract urinary cancer (UTUC) conservative treatment. An adequate quality of vision is mandatory to help surgeon having better outcomes. No studies have been done, to our knowledge, about what fURS on the market has the best quality of vision. Material and Methods Seven different fURS were used to compare the image quality (Lithovue, OlympusV, OlympusV2, Storz FlexXC - in White Light and in ClaraChroma mode - , Wolf Cobra Vision, Olympus P6 and Storx Flex X2)...
March 21, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29534873/durability-of-flexible-ureteroscopes-a-prospective-evaluation-of-longevity-the-factors-that-affect-it-and-damage-mechanisms
#10
Jaap D Legemate, Guido M Kamphuis, Jan Erik Freund, Joyce Baard, Stefano P Zanetti, Michele Catellani, Harry W Oussoren, Jean J de la Rosette
BACKGROUND: Flexible ureteroscopy is an established treatment modality for evaluating and treating abnormalities in the upper urinary tract. Reusable ureteroscope (USC) durability is a significant concern. OBJECTIVE: To evaluate the durability of the latest generation of digital and fiber optic reusable flexible USCs and the factors affecting it. DESIGN, SETTING, PARTICIPANTS: Six new flexible USCs from Olympus and Karl Storz were included...
March 10, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29494349/phenotypic-multiorgan-involvement-of-subclinical-disease-as-quantified-by-magnetic-resonance-imaging-in-subjects-with-prediabetes-diabetes-and-normal-glucose-tolerance
#11
Corinna Storz, Susanne Rospleszcz, Roberto Lorbeer, Holger Hetterich, Sigrid D Auweter, Wieland Sommer, Jürgen Machann, Sergios Gatidis, Wolfgang Rathmann, Margit Heier, Birgit Linkohr, Christa Meisinger, Maximilian Reiser, Udo Hoffmann, Annette Peters, Christopher L Schlett, Fabian Bamberg
INTRODUCTION: Detailed mechanisms in the pathophysiology of diabetes disease are poorly understood, but structural alterations in various organ systems incur an elevated risk for cardiovascular events and adverse outcome. The aim of this study was to compare multiorgan subclinical disease phenotypes by magnetic resonance (MR) imaging to study differences between subjects with prediabetes, diabetes, and normal controls. MATERIALS AND METHODS: Subjects without prior cardiovascular disease were enrolled in a prospective case-control study and underwent multiorgan MR for the assessment of metabolic and arteriosclerotic alterations, including age-related white matter changes, hepatic proton density fat fraction, visceral adipose tissue volume, left ventricular remodeling index, carotid plaque, and late gadolinium enhancement...
February 28, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29488092/characteristics-of-the-parathyroid-gland-in-endoscopic-thyroidectomy-with-the-application-of-an-image-enhancement-system
#12
Peiliang Lin, Ping Han, Faya Liang, Qian Cai, Renhui Chen, Shitong Yu, Zhiwei Zhou, Xiaoming Huang
BACKGROUND: To assist surgeons in identifying and preserving the parathyroid gland (PTG) in endoscopic thyroidectomy (ET), we have summarized the characteristics of the PTG and the surrounding tissues in ET by applying the Storz Professional Image Enhancement System (SPIES). METHODS: From November 2014 to May 2016, 182 patients with 613 suspected PTGs were included in our study. The shape, color, area, and density of surface blood vessels (SBVs); whether they were encapsulated with adipose tissue; and whether congestion was present during the operation were summarized...
February 27, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29465200/-the-choice-of-tracheal-intubation-method-in-reconstructive-maxillo-facial-surgery-with-difficult-airways
#13
A Yu Zaytcev, K V Dubrovin, V A Svetlov
BACKGROUND: The development of modern video - and endoscopic equipment allows for revision and adjust to modern protocols for maintaining patency of the difficult airway, especially in maxillofacial or ENT -surgery. THE PURPOSE OF THE STUDY: Comparison the efficacy ofvarious methods of maintaining the airway patency in the practice of reconstructive maxillofacial surgery. MATERIALS AND METHODS: 89 patients, who were divided into 4 groups, were examined...
September 2017: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/29465085/protein-kinase-d1-gatekeeper-of-the-epithelial-phenotype-and-key-regulator-of-cancer-metastasis
#14
EDITORIAL
Peter Storz
No abstract text is available yet for this article.
February 20, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29458899/single-port-access-laparoscopic-subtotal-hysterectomy-using-contained-manual-morcellation-experience-from-a-tertiary-referral-center-in-taiwan
#15
Shih-Shien Weng, Yi-Chun Chou, Fang-Ju Sun
OBJECTIVE: To describe the surgical outcomes of single port access laparoscopic subtotal hysterectomy (LSH) using in-bag manual morcellation and evaluate the feasibility of this procedure. MATERIALS AND METHODS: Thirty patients with symptomatic leiomyoma or adenomyosis were enrolled. A 2-cm transverse incision was made at the umbilicus and single port apparatus (LagiPort) was applied. After dissection of vesicouterine peritoneum from the uterus, the uterine ligaments and vessels were secured and transected by Gyrus PK cutting forceps...
February 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29455219/endoscopic-transsphenoidal-approach-to-skull-base-lesions-a-clinical-prospective-study
#16
Moneer K Faraj, Wissam J Sagban
OBJECTIVE: To review the patients operated by endoscopic transphenoidal approach for skull base lesions. All the clinical data including age, gender, type of pathology, surgical outcome and surgical complications were studied. METHODS: A clinical prospective study was conducted on 94 cases with skull base lesion that were treated in Neuroscience Hospital in Baghdad, Iraq between October 2011 and December 2016. We followed each patient for an average of 2 years after surgery to determine most common lesion involving the skull base, age and gender distribution, surgical outcome, complications and hospital accommodation...
January 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/29439320/of-patents-and-patent-disputes-the-tnf%C3%AE-patent-files-part-2-enbrel-remicade-cimzia-and-simponi
#17
Ulrich Storz
This article is the second part of a trilogy that discusses IP issues related to anti-Tumor Necrosis factor α (TNFα) biologics. TNFα is the world's most valuable target, with accumulated sales of TNFα biologics of 34 bn USD in 2014. While in the first part of this trilogy, Humira was discussed, this second parts discusses the patent strategies of Enbrel, Remicade, Cimzia and Simponi.
February 5, 2018: Human Antibodies
https://www.readbyqxmd.com/read/29436200/digital-videoscopic-retrograde-intrarenal-surgeries-for-renal-stones-time-to-maximal-stone-length-ratio-analysis
#18
Jae Yong Jeong, Jong Chan Kim, Dong Hyuk Kang, Joo Yong Lee
PURPOSE: To investigate 100 consecutive cases of videoscopic retrograde intrarenal surgery (RIRS) by a single surgeon and to evaluate factors associated with stone-free status and the learning curve thereof. MATERIALS AND METHODS: We analyzed the results of videoscopic RIRS in 100 patients who underwent primary treatment for renal stones from January 2015 to August 2016. Videoscopic RIRS were performed with URF-V and URF-V2 flexible video uteroscopes (Olympus) or a Flex-Xc flexible ureterorenoscope (KARL STORZ)...
March 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29432191/divergent-and-parallel-routes-of-biochemical-adaptation-in-high-altitude-passerine-birds-from-the-qinghai-tibet-plateau
#19
Xiaojia Zhu, Yuyan Guan, Anthony V Signore, Chandrasekhar Natarajan, Shane G DuBay, Yalin Cheng, Naijian Han, Gang Song, Yanhua Qu, Hideaki Moriyama, Federico G Hoffmann, Angela Fago, Fumin Lei, Jay F Storz
When different species experience similar selection pressures, the probability of evolving similar adaptive solutions may be influenced by legacies of evolutionary history, such as lineage-specific changes in genetic background. Here we test for adaptive convergence in hemoglobin (Hb) function among high-altitude passerine birds that are native to the Qinghai-Tibet Plateau, and we examine whether convergent increases in Hb-O2 affinity have a similar molecular basis in different species. We documented that high-altitude parid and aegithalid species from the Qinghai-Tibet Plateau have evolved derived increases in Hb-O2 affinity in comparison with their closest lowland relatives in East Asia...
February 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29397126/universal-videolaryngoscopy-a-structured-approach-to-conversion-to-videolaryngoscopy-for-all-intubations-in-an-anaesthetic-and-intensive-care-department
#20
T M Cook, N J Boniface, C Seller, J Hughes, C Damen, L MacDonald, F E Kelly
BACKGROUND: Videolaryngoscopy (VL) is increasingly used, but not yet routine practice, for tracheal intubation. Few departments formally trial equipment before adopting it into practice. We describe the decision-making and implementation processes that our department used when introducing universal VL, with the C-MAC© (Karl Storz, Germany), throughout our anaesthesia and intensive care departments. METHODS: We used a structured process to assess the feasibility of a change to universal VL...
January 2018: British Journal of Anaesthesia
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