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https://www.readbyqxmd.com/read/29045251/novel-endoscopic-visualization-techniques-for-bladder-cancer-detection-a-review-of-the-contemporary-literature
#1
Andrea Mari, Mohammad Abufaraj, Killian M Gust, Shahrokh F Shariat
PURPOSE OF REVIEW: To describe the principles of photodynamic diagnosis (PDD), narrow-band imaging (NBI) and Storz Professional Image Enhancement System (SPIES) techniques for the endoscopic management of nonmuscle-invasive bladder cancer (BCa) and to report their impact on clinical practice. RECENT FINDINGS: PDD is associated with an increased sensitivity for detecting BCa specifically carcinoma in situ (CIS). Moreover, PDD has been shown to lower recurrence rate in comparison with white-light cystoscopy...
October 17, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29026668/fourth-ventricle-neurocysticercosis-rigid-endoscopic-management-description-of-direct-transcerebellar-approach
#2
A Ceja-Espinosa, J A Franco-Jiménez, A Sosa-Nájera, G A Gutiérrez-Aceves, M I Ruiz-Flores
BACKGROUND: Endoscopy has gained a crucial role in high specialty neurosurgery during the last decades. At present, there are well-defined flexible neuroendoscopic procedures to treat ventricular and subarachnoid space pathologies. Neurocysticercosis is recognized as a common cause of neurologic disease in developing countries and the United States. Surgical intervention, especially cerebrospinal fluid diversion, is the key for management of hydrocephalus. In 2002, a consensus suggested that ventricular forms should be treated with endoscopy as the first option...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29022781/near-infrared-autofluorescence-imaging-to-detect-parathyroid-glands-in-thyroid-surgery
#3
R Ladurner, N Al Arabi, U Guendogar, Kkj Hallfeldt, H Stepp, Jks Gallwas
Objective To identify and save parathyroid glands during thyroidectomy by displaying their autofluorescence. Methods Autofluorescence imaging was carried out during thyroidectomy with and without central lymph node dissection. After visual recognition by the surgeon, the parathyroid glands and the surrounding tissue were exposed to near-infrared light with a wavelength of 690-770 nm using a modified Karl Storz near infrared/indocyanine green endoscopic system. Parathyroid tissue was expected to show near infrared autofluorescence at 820 nm, captured in the blue channel of the camera...
September 15, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28978227/next-generation-single-use-ureteroscopes-an-in-vitro-comparison
#4
Westin Tom, Daniel Arthur Wollin, Ruiyang Jiang, Daniela Radvak, W Neal Simmons, Glenn M Preminger, Michael Eric Lipkin
INTRODUCTION: Single-use ureteroscopes have been gaining popularity in recent years. We compare the optics, deflection, and irrigation flow of two novel single-use flexible ureteroscopes - the YC-FR-A and the NeoFlex - to contemporary reusable and single-use flexible ureteroscopes. METHODS: Five flexible ureteroscopes, YC-FR-A (YouCare Tech, China), NeoFlex (Neoscope Inc, USA), LithoVue (Boston Scientific, USA), Flex-Xc (Karl Storz, Germany), and Cobra (Richard Wolf, Germany), were assessed in vitro for image resolution, distortion, field of view, depth of field, color representation, and grayscale imaging...
October 5, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28971788/prospective-evaluation-of-flexible-ureteroscopes-with-a-novel-evaluation-tool
#5
John Roger Bell, Kristina L Penniston, Sara L Best, Stephen Y Nakada
INTRODUCTION: Assess the function and handling in the clinical setting of three different types of reusable or disposable ureteroscopes using a novel, comprehensive flexible ureteroscope evaluation tool. MATERIALS AND METHODS: Urologists used a fiberoptic (Olympus URF-P5/P6), digital reusable (Storz Flex Xc), or a new digital disposable ureteroscope (Boston Scientific LithoVue) during ureteroscopic laser lithotripsy. An investigator-designed evaluation tool was used to prospectively assess the performance and handling of the ureteroscopes related to user comfort, maneuverability, efficiency, and various mechanical qualities...
October 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28950340/myocardial-tissue-characterization-by-contrast-enhanced-cardiac-magnetic-resonance-imaging-in-subjects-with-prediabetes-diabetes-and-normal-controls-with-preserved-ejection-fraction-from-the-general-population
#6
Corinna Storz, Holger Hetterich, Roberto Lorbeer, Sophia D Heber, Anina Schafnitzel, Hanna Patscheider, Sigrid Auweter, Tanja Zitzelsberger, Wolfgang Rathmann, Konstantin Nikolaou, Maximilian Reiser, Christopher L Schlett, Florian von Knobelsdorff-Brenkenhoff, Annette Peters, Jeanette Schulz-Menger, Fabian Bamberg
Aims: To characterize changes in the myocardium in subjects with prediabetes, diabetes, and healthy controls with preserved left ventricular ejection fraction (LVEF) by using cardiac magnetic resonance imaging (CMR) in a sample from the general population. Methods and results: Subjects without history of cardiovascular disease and preserved LVEF but established diabetes, prediabetes, and controls from a population-based cohort underwent contrast-enhanced CMR. Obtained parameters included left ventricular (LV) function and morphology, late gadolinium enhancement as well as T1-mapping and derivation of extracellular volume fraction (ECV) by modified Look-Locker inversion recovery for diffuse fibrosis in a subset of patients...
July 26, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28939481/laparoscopic-typical-and-atypical-locations-of-sentinel-node-mapping-with-indocyanine-green-comparison-of-two-near-infrared-fluorescence-systems
#7
Giampaolo Di Martino, Claudio Reato, Debora Verri, Federica Dell'Orto, Alessandro Buda
STUDY OBJECTIVE: To present our minimally invasive laparoscopic approach for sentinel lymph node (SLN) mapping with indocyanine green (ICG) fluorescence using with two florescence systems. DESIGN: step by step video description of the technique showing the most frequent typical and atypical location of SLN's (educational video). SETTING: Lymph node staging in apparent confined endometrial cancer. PATIENTS: women underwent sentinel node mapping in a minimally invasive setting...
September 19, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28936612/endotracheal-intubation-ultrasound-guided-versus-fiberscope-in-patients-with-cervical-spine-immobilization
#8
Moustafa Abdelaziz Moustafa, Emad A Arida, Ola M Zanaty, Sameh Fathy El-Tamboly
BACKGROUND: Ultrasound has growing applications in airway management during anesthesia. The aim of the present study was to evaluate the feasibility of real-time ultrasound-guided tracheal intubation in patients with cervical spine immobilization relative to fiberscope-guided tracheal intubation. PATIENTS AND METHODS: This randomized controlled study was carried out on 266 adult patients who have a rigid neck collar in place for cervical spine immobilization and were randomly allocated into two equal groups...
September 21, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28919095/laparoscopic-near-infrared-fluorescent-imaging-as-an-alternative-option-for-sentinel-lymph-node-mapping-in-endometrial-cancer-a-prospective-study
#9
Salih Taşkın, Yavuz Emre Şükür, Duygu Altın, Cevriye Cansız Ersöz, Batuhan Turgay, Duygu Kankaya, Mete Güngör, Fırat Ortaç
BACKGROUND: To evaluate feasibility of sentinel lymph node (SLN) mapping by using near-infrared fluorescent imaging and indocyanine green (NIR/ICG) integrated laparoscopic system in clinically uterine-confined endometrial cancer. MATERIALS AND METHODS: Patients with clinically early-stage endometrial cancer were included in this prospective study. ICG was injected to the uterine cervix and NIR/ICG integrated laparoscopic system (Spies Full HD D-Light P ICG technology, Karl Storz, Tuttlingen, Germany) was used during the operations...
September 14, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28911828/laparoscopic-sentinel-lymph-node-mapping-with-indocyanine-green-icg-using-ispies-platform-the-initial-experience-in-argentina
#10
Julian Di Guilmi, Maria Cecilia Darin, Maria Toscano, Gustavo Maya
OBJECTIVE: To demonstrate the initial experience in Argentina using the iSpies ICG platform in performing sentinel lymph node mapping in early-stage cervical cancer. Design Step-by-step video and pictures BACKGROUND: Laparoscopic and robotic sentinel lymph node mapping using ICG has been shown to be safe and feasible. However, the use of fluorescent imaging through a minimally invasive approach in developing countries is very limited given the cost restrictions of acquiring the near infrared technology and the fluorescent dyes...
September 11, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28902792/paracrine-secretion-of-transforming-growth-factor-%C3%AE-by-ductal-cells-promotes-acinar-to-ductal-metaplasia-in-cultured-human-exocrine-pancreas-tissues
#11
Naoki Akanuma, Jun Liu, Geou-Yarh Liou, Xue Yin, Kaitlyn R Bejar, Chengyang Liu, Lu-Zhe Sun, Peter Storz, Pei Wang
OBJECTIVE: We aimed to evaluate the contribution of acinar-to-ductal metaplasia (ADM) to the accumulation of cells with a ductal phenotype in cultured human exocrine pancreatic tissues and reveal the underlying mechanism. METHODS: We sorted and cultured viable cell populations in human exocrine pancreatic tissues with a flow cytometry-based lineage tracing method to evaluate possible mechanisms of ADM. Cell surface markers, gene expression pattern, and sphere formation assay were used to examine ADM...
October 2017: Pancreas
https://www.readbyqxmd.com/read/28842658/src-mediated-tyrosine-phosphorylation-of-protein-kinase-d2-at-focal-adhesions-regulates-cell-adhesion
#12
Nisha Durand, Ligia I Bastea, Heike Döppler, Tim Eiseler, Peter Storz
Dependent on their cellular localization, Protein Kinase D (PKD) enzymes regulate different processes including Golgi transport, cell signaling and response to oxidative stress. The localization of PKD within cells is mediated by interaction with different lipid or protein binding partners. With the example of PKD2, we here show that phosphorylation events can also contribute to localization of subcellular pools of this kinase. Specifically, in the present study, we show that tyrosine phosphorylation of PKD2 at residue Y87 defines its localization to the focal adhesions and leads to activation...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28839010/circulatory-mechanisms-underlying-adaptive-increases-in-thermogenic-capacity-in-high-altitude-deer-mice
#13
Kevin B Tate, Catherine M Ivy, Jonathan P Velotta, Jay F Storz, Grant B McClelland, Zachary A Cheviron, Graham R Scott
We examined the circulatory mechanisms underlying adaptive increases in thermogenic capacity in deer mice (Peromyscus maniculatus) native to the cold hypoxic environment at high altitudes. Deer mice from high- and low-altitude populations were born and raised in captivity to adulthood, and then acclimated to normoxia or hypobaric hypoxia (simulating hypoxia at ∼4300 m). Thermogenic capacity [maximal O2 consumption (V̇O2,max), during cold exposure] was measured in hypoxia, along with arterial O2 saturation (SaO2 ) and heart rate (fH)...
October 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28833531/insufficient-sleep-enhanced-risk-seeking-relates-to-low-local-sleep-intensity
#14
Angelina Maric, Eszter Montvai, Esther Werth, Matthias Storz, Janina Leemann, Sebastian Weissengruber, Christian C Ruff, Reto Huber, Rositsa Poryazova, Christian R Baumann
OBJECTIVES: Chronic sleep restriction is highly prevalent in modern society and is, in its clinical form, insufficient sleep syndrome, one of the most prevalent diagnoses in clinical sleep laboratories, with substantial negative impact on health and community burden. It reflects every-day sleep loss better than acute sleep deprivation, but its effects and particularly the underlying mechanisms remain largely unknown for a variety of critical cognitive domains, as, for example, risky decision making...
September 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28826907/protein-kinase-c-isoforms-in-the-normal-pancreas-and-in-pancreatic-disease
#15
REVIEW
Alicia K Fleming, Peter Storz
Protein Kinase C isoforms have been implicated in regulating multiple processes within the healthy pancreas. Moreover, their dysregulation contributes to all aspects of pancreatic disease. In this review, with a focus on acinar, ductal, and islet cells, we highlight the roles and contributions of the different PKC isoforms to normal pancreas function. We also discuss the contribution of PKC enzymes to pancreatic diseases, including insulin resistance and diabetes mellitus, as well as pancreatitis and the development and progression of pancreatic cancer...
August 18, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28817961/evaluating-the-ergonomics-of-flexible-ureteroscopy
#16
Wesley W Ludwig, Gyusung Lee, Justin B Ziemba, Joan S Ko, Brian R Matlaga
INTRODUCTION: To date, the ergonomics of flexible ureteroscopy (URS) have not been well described. We performed a study to assess the biomechanical stresses on urologists performing URS and to investigate the effect of ureteroscope type on these parameters. METHODS: Electromyography (EMG) was used to quantify the activation level of muscle groups involved in URS. Surface EMG electrodes (Delsys, Boston, MA) were placed on the right and left thenar, flexor carpi ulnaris (FCU), extensor carpi ulnaris (ECU), biceps, triceps, and deltoid...
October 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28807805/laparoscopic-sentinel-node-mapping-in-cervical-and-endometrial-malignancies-a-case-control-study-comparing-two-near-infrared-fluorescence-systems
#17
Alessandro Buda, Giampaolo Di Martino, Elena De Ponti, Paolo Passoni, Federica Sina, Claudio Reato, Francesca Vecchione, Daniela Giuliani
STUDY OBJECTIVE: The goal of this study was to evaluate the intraoperative and perioperative surgical outcomes of 2 different florescence systems commonly used for sentinel lymph node (SLN) mapping in women with early-stage cervical cancer or endometrial cancer. DESIGN: Case-control study (Canadian Task Force classification II-2). SETTING: The Gynecology Oncology Surgical Unit of the San Gerardo Hospital, Italy. PATIENTS: Thirty-four consecutive women with early stage-cervical cancer (stage IA-1B1) or apparent confined stage I endometrial cancer were included in the study...
August 12, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28750620/efficacy-of-commercialised-extracorporeal-shock-wave-lithotripsy-service-a-review-of-589-renal-stones
#18
Tommy Kjærgaard Nielsen, Jørgen Bjerggaard Jensen
BACKGROUND: Extracorporeal shockwave lithotripsy (ESWL) is the management of choice for renal stones 20 mm or smaller, with a stone clearance rate of up to 89%. The purpose of the present is to investigate the efficacy of a commercialised ESWL service, being performed as an outsourced treatment using a mobile lithotripsy system on an outpatient basis. Furthermore, the study aims to evaluate the risk of needing treatment with an internal ureteral double-J stent (JJ) after ESWL treatment...
July 27, 2017: BMC Urology
https://www.readbyqxmd.com/read/28656505/videoexoscopic-real-time-intraoperative-navigation-for-spinal-neurosurgery-a-novel-co-adaptation-of-two-existing-technology-platforms-technical-note
#19
Meng Huang, Sean Michael Barber, William James Steele, Zain Boghani, Viren Rajendrakumar Desai, Gavin Wayne Britz, George Alexander West, Todd Wilson Trask, Paul Joseph Holman
Image-guided approaches to spinal instrumentation and interbody fusion have been widely popularized in the last decade [1-5]. Navigated pedicle screws are significantly less likely to breach [2, 3, 5, 6]. Navigation otherwise remains a point reference tool because the projection is off-axis to the surgeon's inline loupe or microscope view. The Synaptive robotic brightmatter drive videoexoscope monitor system represents a new paradigm for off-axis high-definition (HD) surgical visualization. It has many advantages over the traditional microscope and loupes, which have already been demonstrated in a cadaveric study [7]...
June 27, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28639695/glycogen-synthase-kinase-3%C3%AE-ablation-limits-pancreatitis-induced-acinar-to-ductal-metaplasia
#20
Li Ding, Geou-Yarh Liou, Daniel M Schmitt, Peter Storz, Jin-San Zhang, Daniel D Billadeau
Acinar-to-ductal metaplasia (ADM) is a reversible epithelial transdifferentiation process that occurs in the pancreas in response to acute inflammation. ADM can rapidly progress towards pre-malignant pancreatic intraepithelial neoplasia (PanIN) lesions in the presence of mutant KRas and ultimately pancreatic adenocarcinoma (PDAC). In the present work, we elucidate the role and related mechanism of glycogen synthase kinase-3beta (GSK-3β) in ADM development using in vitro 3D cultures and genetically engineered mouse models...
September 2017: Journal of Pathology
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