keyword
MENU ▼
Read by QxMD icon Read
search

storz

keyword
https://www.readbyqxmd.com/read/27890314/endoscopic-surgery-in-children-the-challenge-goes-on
#1
REVIEW
David C van der Zee
: Paediatric endoscopic surgery is greatly indebted to Karl Storz for developing paediatric endoscopic instruments. In more recent years, there is an increasing interest in endoscopic surgery in neonates. Now more complex procedures are being performed, although it will take another generation before these will be more generally applied. One of the key factors to success is training. More sophisticated training models are becoming available, allowing practicing in a safe environment before putting the procedure to practice...
November 12, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27870848/genetically-blocking-the-zebrafish-pineal-clock-affects-circadian-behavior
#2
Zohar Ben-Moshe Livne, Shahar Alon, Daniela Vallone, Yared Bayleyen, Adi Tovin, Inbal Shainer, Laura G Nisembaum, Idit Aviram, Sima Smadja-Storz, Michael Fuentes, Jack Falcón, Eli Eisenberg, David C Klein, Harold A Burgess, Nicholas S Foulkes, Yoav Gothilf
The master circadian clock in fish has been considered to reside in the pineal gland. This dogma is challenged, however, by the finding that most zebrafish tissues contain molecular clocks that are directly reset by light. To further examine the role of the pineal gland oscillator in the zebrafish circadian system, we generated a transgenic line in which the molecular clock is selectively blocked in the melatonin-producing cells of the pineal gland by a dominant-negative strategy. As a result, clock-controlled rhythms of melatonin production in the adult pineal gland were disrupted...
November 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27865900/detection-of-potentially-unnecessary-and-wasteful-clinical-trial-research-cumulative-meta-epidemiological-and-trial-sequential-analysis
#3
Philipp Storz-Pfennig
OBJECTIVE: The objective was to estimate the presence and extent to which potentially unnecessary and therefore maybe wasteful clinical trials regarding relevant interventions and outcomes in major clinical areas had been conducted. STUDY DESIGN AND METHODS: From current Cochrane collaboration systematic reviews in major medical fields (e.g. CVD, cancer, psychiatry) 13 different comparisons were sampled. A cumulative meta-analysis was conducted for each and trial sequential analysis applied to determine when in the course of evidence accrual evidence was found sufficient to reach a reliable conclusion...
November 16, 2016: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/27846568/predictable-convergence-in-hemoglobin-function-has-unpredictable-molecular-underpinnings
#4
Chandrasekhar Natarajan, Federico G Hoffmann, Roy E Weber, Angela Fago, Christopher C Witt, Jay F Storz
To investigate the predictability of genetic adaptation, we examined the molecular basis of convergence in hemoglobin function in comparisons involving 56 avian taxa that have contrasting altitudinal range limits. Convergent increases in hemoglobin-oxygen affinity were pervasive among high-altitude taxa, but few such changes were attributable to parallel amino acid substitutions at key residues. Thus, predictable changes in biochemical phenotype do not have a predictable molecular basis. Experiments involving resurrected ancestral proteins revealed that historical substitutions have context-dependent effects, indicating that possible adaptive solutions are contingent on prior history...
October 21, 2016: Science
https://www.readbyqxmd.com/read/27846167/application-of-fluorescent-cholangiography-for-determination-of-the-resection-line-during-a-single-incision-laparoscopic-cholecystectomy-for-a-benign-lesion-of-the-cystic-duct-preliminary-experience
#5
Motoi Nojiri, Tsuyoshi Igami, Hiroshi Tanaka, Yoshitaka Toyoda, Tomoki Ebata, Yukihiro Yokoyama, Gen Sugawara, Takashi Mizuno, Junpei Yamaguchi, Masato Nagino
BACKGROUND: To avoid bile leakage from the stump of a cystic duct that is closed at edematous and/or involved areas, the decision regarding the location of the resection line during a laparoscopic cholecystectomy for benign lesions extending into the cystic duct is important and requires technical ingenuity. For these situations, we used fluorescent cholangiography. METHODS: Our procedure for single-incision laparoscopic cholecystectomy utilized the SILS-Port, and an additional pair of 5-mm forceps was inserted via an umbilical incision...
November 14, 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/27844237/intraoperative-near-infrared-autofluorescence-imaging-of-parathyroid-glands
#6
Roland Ladurner, Sandra Sommerey, Nora Al Arabi, Klaus K J Hallfeldt, Herbert Stepp, Julia K S Gallwas
OBJECTIVE: To identify parathyroid glands intraoperatively by exposing their autofluorescence using near-infrared light. METHODS: Fluorescence imaging was carried out during minimally invasive and open parathyroid and thyroid surgery. After identification, the parathyroid glands as well as the surrounding tissue were exposed to near-infrared (NIR) light with a wavelength of 690-770 nm using a modified Karl Storz near-infrared/indocyanine green (NIR/ICG) endoscopic system...
November 14, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27819651/endoscopic-assisted-cochlear-implantation-a-case-series
#7
Kadir Serkan Orhan, Beldan Polat, Mehmet Çelik, Şenol Çomoğlu, Yahya Güldiken
The aim of the present study was to describe the use of the endoscopic-assisted cochlear implantation in cases with an unsuccessful standard surgical technique because of not achieving adequate exposure to the round window (RW). Three patients with a bilateral profound hearing loss were operated using an endoscopic-assisted cochlear implant procedure at our tertiary university referral center between 2012 and 2014. In all of the patients, a retroauricular "c" shaped incision was performed and a subperiosteal pocket was created...
November 7, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27805769/basal-ganglia-dysfunction-in-complex-regional-pain-syndrome-a-valid-hypothesis
#8
REVIEW
M Azqueta-Gavaldon, H Schulte-Göcking, C Storz, S Azad, A Reiners, D Borsook, L Becerra, E Kraft
: Complex regional pain syndrome (CRPS) is a poorly understood pain disorder of the limbs. Maladaptive cortical plasticity has been shown to play a major role in its pathophysiological presentation. Recently, there is increasing interest in the role of the basal ganglia (BG), since clinical findings and neuroimaging studies point to possible BG involvement in CRPS. CRPS symptoms are often characterized by movement disorders associated with BG dysfunction. Very frequently, dystonia and tremor are reported and, to a lesser extent, myoclonus...
November 2, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27802149/hemoglobin-oxygen-affinity-in-high-altitude-vertebrates-is-there-evidence-for-an-adaptive-trend
#9
REVIEW
Jay F Storz
In air-breathing vertebrates at high altitude, fine-tuned adjustments in hemoglobin (Hb)-O2 affinity provide an energetically efficient means of mitigating the effects of arterial hypoxemia. However, it is not always clear whether an increased or decreased Hb-O2 affinity should be expected to improve tissue O2 delivery under different degrees of hypoxia, due to the inherent trade-off between arterial O2 loading and peripheral O2 unloading. Theoretical results indicate that the optimal Hb-O2 affinity varies as a non-linear function of environmental O2 availability, and the threshold elevation at which an increased Hb-O2 affinity becomes advantageous depends on the magnitude of diffusion limitation (the extent to which O2 equilibration at the blood-gas interface is limited by the kinetics of O2 exchange)...
October 15, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27800291/comparison-of-extracorporeal-shock-wave-lithotripsy-for-urolithiasis-between-children-and-adults-a-single-centre-study
#10
Nadeem Iqbal, Salman Assad, Joshua Rahat Aleman Bhatti, Aisha Hasan, Muhammad Usman Shabbir, Saeed Akhter
OBJECTIVE: To retrospectively evaluate the effectiveness of extracorporeal shock wave lithotripsy (ESWL) for urolithiasis and compare the results between children and adults. MATERIALS AND METHODS: From January 2011 to January 2015 (four years), ESWL was performed in 104 children and 300 adults for urolithiasis. MODULITH(®) SLX-F2 lithotripter (Storz Medical AG, Tägerwilen, Switzerland) equipment was used for ESWL. The stone-free rates, the number of ESWL sessions required, complication rates and ancillary procedures used were evaluated in a comparative manner...
September 29, 2016: Curēus
https://www.readbyqxmd.com/read/27792008/of-patents-and-patent-disputes-the-tnf%C3%AE-patent-files-part-1-humira
#11
Ulrich Storz
This article discusses the patent strategy underlying the world's best selling drug, AbbVie's Humira®. Despite a non-optiimal starting position, AbbVie has established an extensive portfolio to fend off biosimilar competition. This article is the first part of a trilogy that discusses IP issues related to anti-Tumor Necrosis factor α (TNFα) biologics.
October 21, 2016: Human Antibodies
https://www.readbyqxmd.com/read/27776036/just-in-time-video-laryngoscopy-versus-direct-laryngoscopy-for-neonatal-intubation
#12
Erin Grgurich, Cynthia Arnemann, Kim Amon, Rose Horton, Jestin N Carlson
As neonatal endotracheal intubation (ETI) is a low-frequency, high-consequence event, it is essential that providers have access to resources to aid in ETI. We sought to determine the impact of video laryngoscopy (VL) with just-in-time training on intubation outcomes over direct laryngoscopy (DL) when performed by neonatal nurses. We conducted a prospective, randomized, crossover study with neonatal nurses employed at a level 2 neonatal intensive care unit (NICU). Nurses performed both DL and VL on a neonatal mannequin using a CMAC (Karl Storz Corp, Tuttlingen, Germany) either with the assistance of the screen (VL) or without (DL)...
October 2016: Journal of Perinatal & Neonatal Nursing
https://www.readbyqxmd.com/read/27775029/protein-kinase-d1-regulates-focal-adhesion-dynamics-and-cell-adhesion-through-phosphatidylinositol-4-phosphate-5-kinase-type-l-%C3%AE
#13
Nisha Durand, Ligia I Bastea, Jason Long, Heike Döppler, Kun Ling, Peter Storz
Focal adhesions (FAs) are highly dynamic structures that are assembled and disassembled on a continuous basis. The balance between the two processes mediates various aspects of cell behavior, ranging from cell adhesion and spreading to directed cell migration. The turnover of FAs is regulated at multiple levels and involves a variety of signaling molecules and adaptor proteins. In the present study, we show that in response to integrin engagement, a subcellular pool of Protein Kinase D1 (PKD1) localizes to the FAs...
October 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27758119/a-usability-comparison-of-laser-suction-hand-pieces-for-percutaneous-nephrolithotomy
#14
Casey A Dauw, Michael Borofsky, Nadya York, James E Lingeman
INTRODUCTION: The holmium laser has revolutionized the practice of minimally invasive endoscopy for kidney stones. Recently, a novel, rigid hand-piece for use in percutaneous nephrolithotomy (PCNL) that couples the holmium laser with suction has been developed. To date, there exists limited data regarding the usability and ergonomics of such treatment systems. We thus sought to compare surgeon-rated usability with three different suction laser hand-pieces in a porcine model. METHODS: We performed bilateral reverse PCNL on 4 female domestic farm pigs...
October 19, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27722069/educational-workshops-with-graduates-of-the-university-of-cape-town-karl-storz-head-and-neck-surgery-fellowship-program-a-model-for-collaboration-in-outreach-to-developing-countries
#15
J J Fagan, J Aswani, J Otiti, V Mushamba, E Liyombo, G Woodson, D Weed, C Zender, K Mannion, J L Netterville, R Wagner, Mark Zafereo
The University of Cape Town Karl Storz Head and Neck Surgery Fellowship is the only head and neck surgery fellowship in Sub-Saharan Africa. This article briefly describes this fellowship and outlines the experience and ongoing collaborative efforts of members of the American Academy of otolaryngology-head and neck surgery with graduates of this program who are now building head and neck surgery programs in East Africa. This educational collaboration avoids many common pitfalls associated with short-term humanitarian outreach and represents a successful model for international collaborative educational efforts with head and neck surgeons in developing countries in Africa...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27711191/vasodilator-stimulated-phosphoprotein-activity-is-required-for-coxiella-burnetii-growth-in-human-macrophages
#16
Punsiri M Colonne, Caylin G Winchell, Joseph G Graham, Frances I Onyilagha, Laura J MacDonald, Heike R Doeppler, Peter Storz, Richard C Kurten, Paul A Beare, Robert A Heinzen, Daniel E Voth
Coxiella burnetii is an intracellular bacterial pathogen that causes human Q fever, an acute flu-like illness that can progress to chronic endocarditis and liver and bone infections. Humans are typically infected by aerosol-mediated transmission, and C. burnetii initially targets alveolar macrophages wherein the pathogen replicates in a phagolysosome-like niche known as the parasitophorous vacuole (PV). C. burnetii manipulates host cAMP-dependent protein kinase (PKA) signaling to promote PV formation, cell survival, and bacterial replication...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27693449/the-economic-implications-of-a-reusable-flexible-digital-ureteroscope-a-cost-benefit-analysis
#17
Christopher J Martin, Sean B McAdams, Haidar Abdul-Muhsin, Victoria M Lim, Rafael Nunez-Nateras, Mark D Tyson, Mitchell R Humphreys
PURPOSE: Questions remain regarding the durability and longevity of flexible ureteroscopes. The objective of this study was to estimate the potential economic benefits of single use, flexible digital ureteroscopes compared to our recent experience with reusable flexible digital ureteroscopes using cost-benefit analysis. MATERIALS AND METHODS: Ureteroscopic procedures were prospectively recorded over the 12-month period of February 2014 to February 2015. All flexible ureteroscopies were performed using Flex X(C) digital ureteroscopes (Karl Storz Endoscopy-America, El Segundo, California)...
September 28, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27663857/-the-most-important-current-guideline-recommendations-on-the-topic-urolithiasis-a-brief-comparison
#18
E Storz, F Kurtz, M Straub
For the development of patient-specific therapies the guidelines offer the physician a valuable catalogue of possible treatment options. They are based on the current level of knowledge and urological research, but also let some space for individual treatment at the same time. In this article, the current guidelines of several urological associations on the topic of urolithiasis regarding recommendations are described and the differences are highlighted.
October 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27662701/immediate-dose-response-effect-of-high-energy-versus-low-energy-extracorporeal-shock-wave-therapy-on-cutaneous-microcirculation
#19
Robert Kraemer, Heiko Sorg, Vinzent Forstmeier, Karsten Knobloch, Eirini Liodaki, Felix Hagen Stang, Peter Mailaender, Tobias Kisch
Elucidation of the precise mechanisms and therapeutic options of extracorporeal shock wave therapy (ESWT) is only at the beginning. Although immediate real-time effects of ESWT on cutaneous hemodynamics have recently been described, the dose response to different ESWT energies in cutaneous microcirculation has never been examined. Thirty-nine Sprague-Dawley rats were randomly assigned to three groups that received either focused high-energy shock waves (group A: total of 1000 impulses, 10 J) to the lower leg of the hind limb, focused low-energy shock waves (group B: total of 300 impulses, 1 J) or placebo shock wave treatment (group C: 0 impulses, 0 J) using a multimodality shock wave delivery system (Duolith SD-1 T-Top, Storz Medical, Tägerwilen, Switzerland)...
December 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27649783/the-prkd1-promoter-is-a-target-of-the-kras-nf-%C3%AE%C2%BAb-pathway-in-pancreatic-cancer
#20
Heike Döppler, Richard Panayiotou, Elizabeth M Reid, Willibroad Maimo, Ligia Bastea, Peter Storz
Increased expression of PRKD1 and its gene product protein kinase D1 (PKD1) are linked to oncogenic signaling in pancreatic ductal adenocarcinoma, but a direct functional relationship to oncogenic KRas has not been established so far. We here describe the PRKD1 gene promoter as a target for oncogenic KRas signaling. We demonstrate that KRas-induced activation of the canonical NF-κB pathway is one mechanism of how PRKD1 expression is increased and identify the binding sites for NF-κB in the PRKD1 promoter...
September 21, 2016: Scientific Reports
keyword
keyword
51023
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"