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Casey A Dauw, Michael Borofsky, Nadya York, James E Lingeman
INTRODUCTION: The holmium laser has revolutionized the practice of minimally invasive endoscopy for kidney stones. Recently, a novel, rigid hand-piece for use in percutaneous nephrolithotomy (PCNL) that couples the holmium laser with suction has been developed. To date, there exists limited data regarding the usability and ergonomics of such treatment systems. We thus sought to compare surgeon-rated usability with three different suction laser hand-pieces in a porcine model. METHODS: We performed bilateral reverse PCNL on 4 female domestic farm pigs...
October 19, 2016: Journal of Endourology
J J Fagan, J Aswani, J Otiti, V Mushamba, E Liyombo, G Woodson, D Weed, C Zender, K Mannion, J L Netterville, R Wagner, Mark Zafereo
The University of Cape Town Karl Storz Head and Neck Surgery Fellowship is the only head and neck surgery fellowship in Sub-Saharan Africa. This article briefly describes this fellowship and outlines the experience and ongoing collaborative efforts of members of the American Academy of otolaryngology-head and neck surgery with graduates of this program who are now building head and neck surgery programs in East Africa. This educational collaboration avoids many common pitfalls associated with short-term humanitarian outreach and represents a successful model for international collaborative educational efforts with head and neck surgeons in developing countries in Africa...
2016: SpringerPlus
Punsiri M Colonne, Caylin G Winchell, Joseph G Graham, Frances I Onyilagha, Laura J MacDonald, Heike R Doeppler, Peter Storz, Richard C Kurten, Paul A Beare, Robert A Heinzen, Daniel E Voth
Coxiella burnetii is an intracellular bacterial pathogen that causes human Q fever, an acute flu-like illness that can progress to chronic endocarditis and liver and bone infections. Humans are typically infected by aerosol-mediated transmission, and C. burnetii initially targets alveolar macrophages wherein the pathogen replicates in a phagolysosome-like niche known as the parasitophorous vacuole (PV). C. burnetii manipulates host cAMP-dependent protein kinase (PKA) signaling to promote PV formation, cell survival, and bacterial replication...
October 2016: PLoS Pathogens
Christopher J Martin, Sean B McAdams, Haidar Abdul-Muhsin, Victoria M Lim, Rafael Nunez-Nateras, Mark D Tyson, Mitchell R Humphreys
PURPOSE: Questions still remain regarding the durability and longevity of flexible ureteroscopes (URS). The objective of this manuscript is to estimate potential economic benefits of the single use flexible digital URS compared to our recent experience with reusable flexible digital URS using cost benefit analysis. MATERIALS AND METHODS: Ureteroscopic procedures were prospectively recorded over a 12-month period (February 2014 - February 2015). All flexible ureteroscopies were performed using the Karl Storz Flex-XC™ digital ureteroscopes...
September 27, 2016: Journal of Urology
E Storz, F Kurtz, M Straub
For the development of patient-specific therapies the guidelines offer the physician a valuable catalogue of possible treatment options. They are based on the current level of knowledge and urological research, but also let some space for individual treatment at the same time. In this article, the current guidelines of several urological associations on the topic of urolithiasis regarding recommendations are described and the differences are highlighted.
October 2016: Der Urologe. Ausg. A
Robert Kraemer, Heiko Sorg, Vinzent Forstmeier, Karsten Knobloch, Eirini Liodaki, Felix Hagen Stang, Peter Mailaender, Tobias Kisch
Elucidation of the precise mechanisms and therapeutic options of extracorporeal shock wave therapy (ESWT) is only at the beginning. Although immediate real-time effects of ESWT on cutaneous hemodynamics have recently been described, the dose response to different ESWT energies in cutaneous microcirculation has never been examined. Thirty-nine Sprague-Dawley rats were randomly assigned to three groups that received either focused high-energy shock waves (group A: total of 1000 impulses, 10 J) to the lower leg of the hind limb, focused low-energy shock waves (group B: total of 300 impulses, 1 J) or placebo shock wave treatment (group C: 0 impulses, 0 J) using a multimodality shock wave delivery system (Duolith SD-1 T-Top, Storz Medical, Tägerwilen, Switzerland)...
September 20, 2016: Ultrasound in Medicine & Biology
Heike Döppler, Richard Panayiotou, Elizabeth M Reid, Willibroad Maimo, Ligia Bastea, Peter Storz
Increased expression of PRKD1 and its gene product protein kinase D1 (PKD1) are linked to oncogenic signaling in pancreatic ductal adenocarcinoma, but a direct functional relationship to oncogenic KRas has not been established so far. We here describe the PRKD1 gene promoter as a target for oncogenic KRas signaling. We demonstrate that KRas-induced activation of the canonical NF-κB pathway is one mechanism of how PRKD1 expression is increased and identify the binding sites for NF-κB in the PRKD1 promoter...
2016: Scientific Reports
Sergios Gatidis, Sophia D Heber, Corinna Storz, Fabian Bamberg
Advances of computational sciences over the last decades have enabled the introduction of novel methodological approaches in biomedical research. Acquiring extensive and comprehensive data about a research subject and subsequently extracting significant information has opened new possibilities in gaining insight into biological and medical processes. This so-called big data approach has recently found entrance into medical imaging and numerous epidemiological studies have been implementing advanced imaging to identify imaging biomarkers that provide information about physiological processes, including normal development and aging but also on the development of pathological disease states...
September 9, 2016: La Radiologia Medica
Corinna Storz, Tobias Geisler, Mike Notohamiprodjo, Konstantin Nikolaou, Fabian Bamberg
Transcatheter aortic valve replacement (TAVR) has emerged as an effective treatment alternative in patients with severe aortic stenosis (AS) who are deemed surgically high-risk or ineligible for surgery. Pre-procedural imaging, in particular computed tomography (CT), plays an integral part in the planning and performance of TAVR and is crucial for a successful treatment. Novel technological advances in CT include high-pitch, low kV acquisitions, and iterative reconstruction resulting in high image quality at substantially reduced scan duration, contrast volume, and radiation exposure...
October 2016: Current Treatment Options in Cardiovascular Medicine
Laura E Edgington-Mitchell, Thomas Wartmann, Alicia K Fleming, Vasilena Gocheva, Wouter A van der Linden, Nimali P Withana, Martijn Verdoes, Luigi Aurelio, Daniel Edgington-Mitchell, TinaMarie Lieu, Belinda S Parker, Bim Graham, Thomas Reinheckel, John B Furness, Johanna A Joyce, Peter Storz, Walter Halangk, Matthew Bogyo, Nigel W Bunnett
Pancreatitis is an inflammatory disease of the pancreas characterized by dysregulated activity of digestive enzymes, necrosis, immune infiltration, and pain. Repeated incidence of pancreatitis is an important risk factor for pancreatic cancer. Legumain, a lysosomal cysteine protease, has been linked to inflammatory diseases such as atherosclerosis, stroke, and cancer. Until now, legumain activation has not been studied during pancreatitis. We used a fluorescently quenched activity-based probe to assess legumain activation during caerulein-induced pancreatitis in mice...
September 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
Michele Diana, Yu-Yin Liu, Raoul Pop, Seong-Ho Kong, Andras Legnèr, Remy Beaujeux, Patrick Pessaux, Luc Soler, Didier Mutter, Bernard Dallemagne, Jacques Marescaux
BACKGROUND: Intraoperative liver segmentation can be obtained by means of percutaneous intra-portal injection of a fluorophore and illumination with a near-infrared light source. However, the percutaneous approach is challenging in the minimally invasive setting. We aimed to evaluate the feasibility of fluorescence liver segmentation by superselective intra-hepatic arterial injection of indocyanine green (ICG). MATERIALS AND METHODS: Eight pigs (mean weight: 26...
August 5, 2016: Surgical Endoscopy
John C Sakles, Jarrod M Mosier, Asad E Patanwala, Brittany Arcaris, John M Dicken
BACKGROUND: Although the C-MAC (Karl Storz, Tuttlingen, Germany) is a video laryngoscope (VL), it can also be used as a direct laryngoscope (DL). OBJECTIVE: The goal of this study was to evaluate the utility of the C-MAC as a DL for intubations in the emergency department (ED). METHODS: This was an analysis of prospectively collected continuous quality-improvement data during the 6-year period from February 1, 2009 to January 31, 2015, when both the C-MAC and Macintosh DL (Mac DL) were clinically available in our ED...
October 2016: Journal of Emergency Medicine
Nathan Y Hoy, Larissa Shapka, Jan Rudzinski, Trevor D Schuler, Timothy A Wollin, Derek Bochinski, Shubha K De
INTRODUCTION AND OBJECTIVE: The manufacturer for the Storz Modulith SLX-F2 lithotripter recommends treatment head exchange after 1.65 million shocks. However, there is no documentation describing longevity of the treatment head with continued usage. The objective of this study is to determine whether there is a difference in stone fragmentation effectiveness with the treatment head at the beginning versus the end of its treatment life. METHODS: We conducted a retrospective chart review of 200 patients-50 consecutive patients treated immediately preceding, and following, two separate treatment head exchanges...
September 2016: Journal of Endourology
Marissa G Vadi, Elizabeth A Ghazal, Bryan Halverson, Richard L Applegate
BACKGROUND: Gaining proficiency with various airway management tools is an important goal for anesthesiology training. Indirect video laryngoscopes facilitate tracheal intubation in adults, but it is not clear whether these findings translate to children. This study evaluates the total time to successful intubation when performed by anesthesiology trainees using GlideScope Cobalt® video laryngoscopy (GlideScope), Storz DCI® video laryngoscopy (Storz), or direct laryngoscopy (Direct) in children <2 years old with normal airway anatomy...
February 2016: Middle East Journal of Anesthesiology
Paolo Sessi, Rudro R Biswas, Thomas Bathon, Oliver Storz, Stefan Wilfert, Alessandro Barla, Konstantin A Kokh, Oleg E Tereshchenko, Kai Fauth, Matthias Bode, Alexander V Balatsky
Topological insulators interacting with magnetic impurities have been reported to host several unconventional effects. These phenomena are described within the framework of gapping Dirac quasiparticles due to broken time-reversal symmetry. However, the overwhelming majority of studies demonstrate the presence of a finite density of states near the Dirac point even once topological insulators become magnetic. Here, we map the response of topological states to magnetic impurities at the atomic scale. We demonstrate that magnetic order and gapless states can coexist...
2016: Nature Communications
Jay F Storz, Zachary A Cheviron
Recent studies of indigenous human populations at high altitude have provided proof-of-principle that genome scans of DNA polymorphism can be used to identify candidate loci for hypoxia adaptation. When integrated with experimental analyses of physiological phenotypes, genome-wide surveys of DNA polymorphism and tissue-specific transcriptional profiles can provide insights into actual mechanisms of adaptation. It has been suggested that adaptive phenotypic evolution is largely mediated by cis-regulatory changes in genes that are located at integrative control points in regulatory networks...
2016: Advances in Experimental Medicine and Biology
S Axt, J Johannink, P Storz, S T Mees, A A Röth, A Kirschniak
BACKGROUND: In-house surgical education and practical training of surgical skills are inhomogeneous in German hospitals and vary greatly in terms of teaching content and forms. The present survey provides an overview of the currently practiced surgical education and practical training of surgical skills in German hospitals. MATERIAL AND METHODS: An online survey was performed among members of the "Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie" (DGAV)...
June 2016: Zentralblatt Für Chirurgie
Geou-Yarh Liou, Peter Storz, Michael Leitges
Pancreatic ductal adenocarcinoma originates from acinar cells that undergo acinar-to-ductal metaplasia (ADM). ADM is initiated in response to growth factors, inflammation, and oncogene activation and leads to a de-differentiated, duct-like phenotype. Our recent publication demonstrated a transforming growth factor α-Kras(G12D)-protein kinase D1-Notch1 signaling axis driving the induction of ADM and further progression to pancreatic intraepithelial neoplasia. This suggests that protein kinase D1 might be an early marker for tumor development and a potential target for drug development...
January 2016: Molecular & Cellular Oncology
Shailesh Puntambekar, Vikrant Sharma, Sanjay Kumar, Sainath Mitkare, Geetanjali Joshi, Atul Dokrimare, Mangesh Panse
The role of endoscopic thyroidectomy has shown clear cosmetic benefits in the past. In this current study of 10 patients, we have tried to highlight the importance and benefits of 3D endoscopy in the management of large size multinodular goitres (MNGs) and solitary thyroid nodules (STNs). From March 2014 to July 2014, patients having a large volume of thyroid (>70 cc for one lobe) and nodule size (>6 cm) were enrolled for this study. A total of 10 patients underwent the procedure using the Karl Storz(TM) 3D endoscope system...
April 2016: Indian Journal of Surgery
Mohammed Baghdadi, Esteban Emiliani, Michele Talso, Pol Servián, Aaron Barreiro, Andrea Orosa, Silvia Proietti, Olivier Traxer
PURPOSE: To examine laser fiber passage capabilities through flexible ureterorenoscopes (fURSs) and to measure deflections and flow characteristics. METHODS: For this in vitro study, eight fURSs were examined (Olympus(®) URF-P6, URF-P6, URF-V, URF-V2; Storz(®) Xc and Flex-X2; Richard Wolf(®) Cobra Vision; and Lithovue). Four laser fibers standard 200- and 273-μm (uncleaved and cleaved), sheath-coated and ball-tip fibers were attempted to pass through each fURS while deflected at 120°, 180°, maximum deflection, and maximum deflection with reduced 9-mm radius...
June 14, 2016: World Journal of Urology
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