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https://www.readbyqxmd.com/read/29239229/in-vitro-evaluation-of-single-use-digital-flexible-ureteroscopes-a-practical-comparison-for-a-patient-centered-approach
#1
Giovanni Scala Marchini, Carlos Alfredo Batagello, Manoj Monga, Fabio Cesar Miranda Torricelli, Fabio Carvalho Vicentini, Alexandre Danilovic, Miguel Srougi, William Carlos Nahas, Eduardo Mazzucchi
OBJECTIVE: to compare the manufacturing and in vitro performance characteristics of two single use flexible ureteroscopes with a permanent optical flexible ureteroscope. MATERIAL AND METHODS: Two single-use flexible ureteroscopes, LithoVue (Boston Scientific, USA) and Pusen (1rs. generation; Zhuhai Pusen Medical Technology Company Limited, China) were tested and compared with a permanent Flex-X2 ureteroscope (Karl Storz, Germany) in terms of technical characteristics, optics, deflection mechanism and additional parameters which could potentially affect surgical technique...
December 14, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29214354/wide-field-autofluorescence-guided-tur-b-for-the-detection-of-bladder-cancer-a-pilot-study
#2
Maximilian C Kriegmair, P Honeck, M Theuring, C Bolenz, M Ritter
PURPOSE: The aim of this pilot study was to assess the feasibility and value of wide-field autofluorescence imaging (AFI) for the detection of bladder cancer during transurethral resection of the bladder (TUR-B). METHODS: For imaging, the D-Light/AF System (Karl Storz GmbH, Tuttlingen, Germany) and a customized band pass filter (≈ 480-780 nm) at the eyepiece of the endoscope were used. The excitation light wavelength was 440 nm. Representative spectral measurements of tissue autofluorescence (AF) were performed using a spectrometer attached behind the AF band pass filter in selected patients...
December 6, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29174188/impact-of-radiation-dose-reduction-in-abdominal-computed-tomography-on-diagnostic-accuracy-and-diagnostic-performance-in-patients-with-suspected-appendicitis-an-intraindividual-comparison
#3
Corinna Storz, Manuel Kolb, Jong Hyo Kim, Jakob Weiss, Wolfgang G Kunz, Konstantin Nikolaou, Fabian Bamberg, Ahmed E Othman
RATIONALE AND OBJECTIVES: To determine the intraindividual impact of radiation dose reduction in abdominal computed tomography (CT) on diagnostic performance in patients with suspected appendicitis. MATERIALS AND METHODS: This study was approved by the institutional review board. Seventy-five patients who underwent standard contrast-enhanced abdominal CT for suspected appendicitis between 2004 and 2009 were retrospectively included. Low-dose CT reconstructions with 75%, 50%, and 25% of the original radiation dose level were generated by applying realistic reduced-dose simulation...
November 23, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29154806/crispr-cas9-licensing-the-unlicensable
#4
REVIEW
Ulrich Storz
A new gene engineering technology has recently made it through the media, not only because of its technical advantages, but also because it is in the focus of an epic patent battle between two academic institutions. The technology bears the cryptic name "CRISPR Cas9", and allows the manipulation of genes (so called "gene editing") with so far unseen simplicity and efficacy. Dana Carroll of the University of Utah said for this reason that CRISPR Cas9 has brought about the "democratization of gene targeting"...
November 14, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/29146391/small-diameter-hysteroscopic-metroplasty-for-a-septate-uterus-after-open-assisted-laparoscopic-radical-trachelectomy
#5
Akimasa Takahashi, Hiroyuki Kanao, Nobuhiro Takeshima
STUDY OBJECTIVE: To describe a two-step fertility preservation technique for early-stage cervical cancer of a patient with a complete septate uterus. DESIGN: A step-by-step demonstration and explanation of the technique in a surgical video (Canadian Task Force Classification III). SETTING: Center for cancer, a tertiary referral center. The patient provided informed consent to use images and videos of the procedure. Institutional Review Board approval was not required for this kind of procedure...
November 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29120697/enhancing-antibody-patent-protection-using-epitope-mapping-information
#6
Xiaoxiang Deng, Ulrich Storz, Benjamin J Doranz
As the $100B therapeutic monoclonal antibody (mAb) market continues to grow, developers of therapeutic mAbs increasingly face the need to strengthen patent protection of their products and enforce their patents in courts. In view of changes in the patent law landscape, patent applications are strategically using information on the precise binding sites of their mAbs, i.e., the epitopes, to support patent novelty, non-obviousness, subject matter, and a tightened written description requirement for broad genus antibody claims...
November 9, 2017: MAbs
https://www.readbyqxmd.com/read/29102235/the-view-through-the-ventricle-catheter-the-new-shuntscope-for-the-therapy-of-pediatric-hydrocephalus
#7
Sebastian Senger, Sebastian Antes, Mohamed Salah, Christoph Tschan, Stefan Linsler, Joachim Oertel
PURPOSE: Correct placement of the ventricle catheter directly influences the function of cerebral shunt systems. The incidence of proximal catheter misplacement reaches up to 45%. To avoid misplacements and revisions a new intra-catheter endoscope for precise ventricle catheter placement in children was evaluated. METHODS: The semi-rigid ShuntScope (Karl Storz GmbH & Co.KG, Tuttlingen, Germany) with an outer diameter of 1.0 mm and an image resolution of 10,000 pixels was used in a series of 27 children and adolescents (18 males, 9 females, age range 2 months-18 years)...
October 25, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29100081/compensatory-mutations-and-epistasis-for-protein-function
#8
REVIEW
Jay F Storz
Adaptive protein evolution may be facilitated by neutral amino acid mutations that confer no benefit when they first arise but which potentiate subsequent function-altering mutations via direct or indirect structural mechanisms. Theoretical and empirical results indicate that such compensatory interactions (intramolecular epistasis) can exert a strong influence on trajectories of protein evolution. For this reason, assessing the form and prevalence of intramolecular epistasis and characterizing biophysical mechanisms of compensatory interaction are important research goals at the nexus of structural biology and molecular evolution...
November 5, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/29078643/indocyanine-green-fluorescence-navigated-thoracoscopic-anatomical-segmentectomy
#9
Mingyon Mun, Sakae Okumura, Masayuki Nakao, Yosuke Matsuura, Ken Nakagawa
BACKGROUND: To evaluate the feasibility and efficacy of thoracoscopic anatomical segmentectomy (TS-S) using three-dimensional computed tomography (3D-CT) reconstruction and indocyanine green-fluorescence (ICGF) navigation. METHODS: Twenty TS-S procedures were performed for 15 primary lung cancers and 5 metastatic lung tumors. Preoperatively we evaluated the target segmental pulmonary artery and created a virtual intersegmental plane using 3D-CT reconstruction. Intraoperatively, the target segmental artery and bronchus were divided, and after intravenous systemic injection of indocyanine green (ICG, 0...
2017: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29045251/novel-endoscopic-visualization-techniques-for-bladder-cancer-detection-a-review-of-the-contemporary-literature
#10
Andrea Mari, Mohammad Abufaraj, Killian M Gust, Shahrokh F Shariat
PURPOSE OF REVIEW: To describe the principles of photodynamic diagnosis (PDD), narrow-band imaging (NBI) and Storz Professional Image Enhancement System (SPIES) techniques for the endoscopic management of nonmuscle-invasive bladder cancer (BCa) and to report their impact on clinical practice. RECENT FINDINGS: PDD is associated with an increased sensitivity for detecting BCa specifically carcinoma in situ (CIS). Moreover, PDD has been shown to lower recurrence rate in comparison with white-light cystoscopy...
October 17, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29026668/fourth-ventricle-neurocysticercosis-rigid-endoscopic-management-description-of-direct-transcerebellar-approach
#11
A Ceja-Espinosa, J A Franco-Jiménez, A Sosa-Nájera, G A Gutiérrez-Aceves, M I Ruiz-Flores
BACKGROUND: Endoscopy has gained a crucial role in high specialty neurosurgery during the last decades. At present, there are well-defined flexible neuroendoscopic procedures to treat ventricular and subarachnoid space pathologies. Neurocysticercosis is recognized as a common cause of neurologic disease in developing countries and the United States. Surgical intervention, especially cerebrospinal fluid diversion, is the key for management of hydrocephalus. In 2002, a consensus suggested that ventricular forms should be treated with endoscopy as the first option...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29022781/near-infrared-autofluorescence-imaging-to-detect-parathyroid-glands-in-thyroid-surgery
#12
R Ladurner, N Al Arabi, U Guendogar, Kkj Hallfeldt, H Stepp, Jks Gallwas
Objective To identify and save parathyroid glands during thyroidectomy by displaying their autofluorescence. Methods Autofluorescence imaging was carried out during thyroidectomy with and without central lymph node dissection. After visual recognition by the surgeon, the parathyroid glands and the surrounding tissue were exposed to near-infrared light with a wavelength of 690-770 nm using a modified Karl Storz near infrared/indocyanine green endoscopic system. Parathyroid tissue was expected to show near infrared autofluorescence at 820 nm, captured in the blue channel of the camera...
September 15, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28978227/next-generation-single-use-ureteroscopes-an-in-vitro-comparison
#13
Westin R Tom, Daniel A Wollin, Ruiyang Jiang, Daniela Radvak, Walter Neal Simmons, Glenn M Preminger, Michael E Lipkin
INTRODUCTION: Single-use ureteroscopes have been gaining popularity in recent years. We compare the optics, deflection, and irrigation flow of two novel single-use flexible ureteroscopes-the YC-FR-A and the NeoFlex-with contemporary reusable and single-use flexible ureteroscopes. METHODS: Five flexible ureteroscopes, YC-FR-A (YouCare Tech, China), NeoFlex (Neoscope, Inc., USA), LithoVue (Boston Scientific, USA), Flex-Xc (Karl Storz, Germany), and Cobra (Richard Wolf, Germany), were assessed in vitro for image resolution, distortion, field of view, depth of field, color representation, and grayscale imaging...
November 3, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28971788/prospective-evaluation-of-flexible-ureteroscopes-with-a-novel-evaluation-tool
#14
John Roger Bell, Kristina L Penniston, Sara L Best, Stephen Y Nakada
INTRODUCTION: Assess the function and handling in the clinical setting of three different types of reusable or disposable ureteroscopes using a novel, comprehensive flexible ureteroscope evaluation tool. MATERIALS AND METHODS: Urologists used a fiberoptic (Olympus URF-P5/P6), digital reusable (Storz Flex Xc), or a new digital disposable ureteroscope (Boston Scientific LithoVue) during ureteroscopic laser lithotripsy. An investigator-designed evaluation tool was used to prospectively assess the performance and handling of the ureteroscopes related to user comfort, maneuverability, efficiency, and various mechanical qualities...
October 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28950340/myocardial-tissue-characterization-by-contrast-enhanced-cardiac-magnetic-resonance-imaging-in-subjects-with-prediabetes-diabetes-and-normal-controls-with-preserved-ejection-fraction-from-the-general-population
#15
Corinna Storz, Holger Hetterich, Roberto Lorbeer, Sophia D Heber, Anina Schafnitzel, Hanna Patscheider, Sigrid Auweter, Tanja Zitzelsberger, Wolfgang Rathmann, Konstantin Nikolaou, Maximilian Reiser, Christopher L Schlett, Florian von Knobelsdorff-Brenkenhoff, Annette Peters, Jeanette Schulz-Menger, Fabian Bamberg
Aims: To characterize changes in the myocardium in subjects with prediabetes, diabetes, and healthy controls with preserved left ventricular ejection fraction (LVEF) by using cardiac magnetic resonance imaging (CMR) in a sample from the general population. Methods and results: Subjects without history of cardiovascular disease and preserved LVEF but established diabetes, prediabetes, and controls from a population-based cohort underwent contrast-enhanced CMR. Obtained parameters included left ventricular (LV) function and morphology, late gadolinium enhancement as well as T1-mapping and derivation of extracellular volume fraction (ECV) by modified Look-Locker inversion recovery for diffuse fibrosis in a subset of patients...
July 26, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28939481/laparoscopic-typical-and-atypical-locations-of-sentinel-node-mapping-with-indocyanine-green-comparison-of-2-near-infrared-fluorescence-systems
#16
Giampaolo Di Martino, Claudio Reato, Debora Verri, Federica Dell'Orto, Alessandro Buda
STUDY OBJECTIVE: To present our minimally invasive laparoscopic approach for sentinel lymph node (SLN) mapping with indocyanine green (ICG) using 2 fluorescence systems. DESIGN: A step-by-step video description of the technique showing the most frequent typical and atypical location of SLNs (educational video). SETTING: Lymph node staging in apparent confined endometrial cancer. PATIENTS: Women underwent SLN mapping in a minimally invasive setting...
September 20, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28936612/endotracheal-intubation-ultrasound-guided-versus-fiberscope-in-patients-with-cervical-spine-immobilization
#17
Moustafa Abdelaziz Moustafa, Emad A Arida, Ola M Zanaty, Sameh Fathy El-Tamboly
BACKGROUND: Ultrasound has growing applications in airway management during anesthesia. The aim of the present study was to evaluate the feasibility of real-time ultrasound-guided tracheal intubation in patients with cervical spine immobilization relative to fiberscope-guided tracheal intubation. PATIENTS AND METHODS: This randomized controlled study was carried out on 266 adult patients who have a rigid neck collar in place for cervical spine immobilization and were randomly allocated into two equal groups...
December 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28919095/laparoscopic-near-infrared-fluorescent-imaging-as-an-alternative-option-for-sentinel-lymph-node-mapping-in-endometrial-cancer-a-prospective-study
#18
Salih Taşkın, Yavuz Emre Şükür, Duygu Altın, Cevriye Cansız Ersöz, Batuhan Turgay, Duygu Kankaya, Mete Güngör, Fırat Ortaç
BACKGROUND: To evaluate feasibility of sentinel lymph node (SLN) mapping by using near-infrared fluorescent imaging and indocyanine green (NIR/ICG) integrated laparoscopic system in clinically uterine-confined endometrial cancer. MATERIALS AND METHODS: Patients with clinically early-stage endometrial cancer were included in this prospective study. ICG was injected to the uterine cervix and NIR/ICG integrated laparoscopic system (Spies Full HD D-Light P ICG technology, Karl Storz, Tuttlingen, Germany) was used during the operations...
November 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28911828/laparoscopic-sentinel-lymph-node-mapping-with-indocyanine-green-using-the-ispies-platform-initial-experience-argentina
#19
Julian Di Guilmi, Maria Cecilia Darin, Maria Toscano, Gustavo Maya
STUDY OBJECTIVE: To demonstrate the initial experience in Argentina using the iSpies indocyanine green (ICG) platform in sentinel lymph node mapping in patients with early-stage cervical cancer. DESIGN: Step-by-step demonstration of the technique using a video and pictures (educative video) (Canadian Task Force classification III). SETTING: Laparoscopic and robotic sentinel lymph node mapping using ICG has been shown to be safe and feasible; however, in developing countries, the opportunities to use fluorescent imaging through a minimally invasive approach are very limited, given the cost restrictions of acquiring the near-infrared technology and the fluorescent dyes...
September 11, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28902792/paracrine-secretion-of-transforming-growth-factor-%C3%AE-by-ductal-cells-promotes-acinar-to-ductal-metaplasia-in-cultured-human-exocrine-pancreas-tissues
#20
Naoki Akanuma, Jun Liu, Geou-Yarh Liou, Xue Yin, Kaitlyn R Bejar, Chengyang Liu, Lu-Zhe Sun, Peter Storz, Pei Wang
OBJECTIVE: We aimed to evaluate the contribution of acinar-to-ductal metaplasia (ADM) to the accumulation of cells with a ductal phenotype in cultured human exocrine pancreatic tissues and reveal the underlying mechanism. METHODS: We sorted and cultured viable cell populations in human exocrine pancreatic tissues with a flow cytometry-based lineage tracing method to evaluate possible mechanisms of ADM. Cell surface markers, gene expression pattern, and sphere formation assay were used to examine ADM...
October 2017: Pancreas
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