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https://www.readbyqxmd.com/read/27010942/the-dena-den1-interacting-phosphatase-dipa-controls-septa-positioning-and-phosphorylation-dependent-stability-of-cytoplasmatic-dena-den1-during-fungal-development
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Josua Schinke, Miriam Kolog Gulko, Martin Christmann, Oliver Valerius, Sina Kristin Stumpf, Margarita Stirz, Gerhard H Braus
DenA/DEN1 and the COP9 signalosome (CSN) represent two deneddylases which remove the ubiquitin-like Nedd8 from modified target proteins and are required for distinct fungal developmental programmes. The cellular DenA/DEN1 population is divided into a nuclear and a cytoplasmatic subpopulation which is especially enriched at septa. DenA/DEN1 stability control mechanisms are different for the two cellular subpopulations and depend on different physical interacting proteins and the C-terminal DenA/DEN1 phosphorylation pattern...
March 2016: PLoS Genetics
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