Josua Schinke, Miriam Kolog Gulko, Martin Christmann, Oliver Valerius, Sina Kristin Stumpf, Margarita Stirz, Gerhard H Braus
DenA/DEN1 and the COP9 signalosome (CSN) represent two deneddylases which remove the ubiquitin-like Nedd8 from modified target proteins and are required for distinct fungal developmental programmes. The cellular DenA/DEN1 population is divided into a nuclear and a cytoplasmatic subpopulation which is especially enriched at septa. DenA/DEN1 stability control mechanisms are different for the two cellular subpopulations and depend on different physical interacting proteins and the C-terminal DenA/DEN1 phosphorylation pattern...
March 2016: PLoS Genetics