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N Arulkumaran, J Lowe, R Ions, M Mendoza, V Bennett, M W Dunser
Videolaryngoscopy (VL) may improve the success of orotracheal intubation compared with direct laryngoscopy (DL). We performed a systematic search of PubMed, Embase, and CENTRAL databases for studies comparing VL and DL for emergency orotracheal intubations outside the operating room. The primary outcome was rate of first-pass intubation, with subgroup analyses by location, device used, clinician experience, and clinical scenario. The secondary outcome was complication rates. Data are presented as [odds ratio (95% confidence intervals); P-values]...
April 2018: British Journal of Anaesthesia
Divya Jain, Swati Mehta, Komal Gandhi, Suman Arora, Badal Parikh, Muneer Abas
BACKGROUND: Endotracheal intubation in lateral position in infants is a challenge. This difficulty may be surmounted to some extent by using videolaryngoscopes but the routine use of these devices as a tool to secure the airway in lateral position remains unevaluated. Therefore, we conducted a prospective, randomized controlled trial to compare the intubation conditions achieved with the CMAC videolaryngoscope and the Miller Laryngoscope in lateral position in infants. We hypothesized that CMAC videolaryngoscope would provide a better laryngoscopic view and reduce the time to intubation compared to the Miller blade...
March 2018: Paediatric Anaesthesia
Marcin Cierniak, Małgorzata Pikala, Joanna Jaskółkowska, Marcin Nowakowski, Bartłomiej Balcerzak, Tomasz Gaszyński
While analysing the use of the new videolaryngoscopes in the hands of the well experienced anaesthesiologists it is difficult to get answers to all intriguing questions and gain insights that might arise only from the untrained users. We can form a thesis that if a manikin, with the use of a particular device, is intubated quickly and effectively by the novices, it is probable that the more experienced operators will be even more satisfied with its use. AIM: The aim of our study was to evaluate the effectiveness of the use of these devices in the hands of the users untrained in intubation...
November 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Pablo A Mendoza, Patricio Silva, Jorge Díaz, Cecilia Arriagada, Jimena Canales, Oscar Cerda, Vicente A Torres
The early endosome protein Rab5 was recently shown to promote cell migration by enhancing focal adhesion disassembly through mechanisms that remain elusive. Focal adhesion disassembly is associated to proteolysis of talin, in a process that requires calpain2. Since calpain2 has been found at vesicles and endosomal compartments, we hypothesized that Rab5 stimulates calpain2 activity, leading to enhanced focal adhesion disassembly in migrating cells. We observed that calpain2 co-localizes with EEA1-positive early endosomes and co-immunoprecipitate with EEA1 and Rab5 in A549 lung carcinoma cells undergoing spreading, whereas Rab5 knock-down decreased the accumulation of calpain2 at early endosomal-enriched fractions...
November 3, 2017: Cell Adhesion & Migration
Anju Gupta, Nishkarsh Gupta
Anterior laryngeal web is a rare anomaly which is usually asymptomatic in infancy. This translates into a high incidence of unanticipated difficult intubation in these patients with consequent airway morbidity in the form of tracheostomy. We are reporting a case of unsuspected difficult intubation in a neonate due to the presence of a congenital anterior laryngeal web. After multiple failed intubation attempts with direct laryngoscopy, use of CMAC video laryngoscope improved the glottic view, enabled us to diagnose the presence of a thick anterior laryngeal web and intubate the child...
January 1, 2018: A&A practice
David Geiringer
Recent interpretations of religious change in modern Britain have stressed the importance of a sudden and abrupt 'sexual revolution' during the 1960s. The role the Churches played in bringing about their own demise remains a point of debate, particularly in the case of the Catholic Church. This article attempts to move beyond existing historical disputes over a 'religious crisis' and whether it was rooted in 'internal' causes (problems within the Church) or 'external', secular developments. It explores the way sexual knowledge was discussed and disseminated by Catholic authorities during this decade of perceived cultural transition, drawing on the previously unpublished papers of the Papal Commission for Birth Control 1963-5 and the training manuals of the Catholic Marriage Advisory Council (CMAC)...
June 1, 2017: 20 Century British History
Hendrik Eismann, Lion Sieg, Nicola Etti, Lars Friedrich, Christian Schröter, Philipp Mommsen, Christian Krettek, Christian Zeckey
BACKGROUND: Videolaryngoscopy has been proven to be a safe procedure managing difficult airways in the hands of airway specialists. Information about the success rates in unexperienced users of videolaryngoscopy compared to conventional laryngoscopy is sparse. Therefore, we aimed to evaluate if there might be more success in securing an airway if the unexperienced provider is using a videolaryngoscope in simulated airways in a randomized manikin study. Differences between commonly used videolaryngoscopes were elucidated...
August 10, 2017: European Journal of Medical Research
Onur Balaban, Mumin Hakim, Hina Walia, Dmitry Tumin, Meredith Lind, Joseph D Tobias
OBJECTIVE: Direct laryngoscopy (DL) is the most common technique for endotracheal intubation, whereas videolaryngoscopy provides an indirect view of the glottis without the need to align the oral, pharyngeal, and tracheal axes. The current study compares videolaryngoscopy with DL among experienced and inexperienced users for endotracheal intubation using a pediatric manikin. METHODS: Participants performed DL using Miller and Macintosh laryngoscopes and videolaryngoscopy using CMAC and GlideScope devices on a manikin (SimBaby; Laerdel, Wappingers Falls, NY)...
June 6, 2017: Pediatric Emergency Care
Erin Grgurich, Cynthia Arnemann, Kim Amon, Rose Horton, Jestin N Carlson
As neonatal endotracheal intubation (ETI) is a low-frequency, high-consequence event, it is essential that providers have access to resources to aid in ETI. We sought to determine the impact of video laryngoscopy (VL) with just-in-time training on intubation outcomes over direct laryngoscopy (DL) when performed by neonatal nurses. We conducted a prospective, randomized, crossover study with neonatal nurses employed at a level 2 neonatal intensive care unit (NICU). Nurses performed both DL and VL on a neonatal mannequin using a CMAC (Karl Storz Corp, Tuttlingen, Germany) either with the assistance of the screen (VL) or without (DL)...
October 2016: Journal of Perinatal & Neonatal Nursing
H J Zhang, F S Luan
The aim of the present study was to develop a transformation system that may be useful for introducing agronomically and biotechnologically relevant traits into melon. The production of transplanted melon with maternal inheritance of the transgene could solve problems related to outcrossing between genetically modified crops and conventional crops or their wild relatives. By analyzing the main influencing factors systematically, the pollination time was ascertained and the pollen-tube pathway genetic transformation system was optimized...
September 23, 2016: Genetics and Molecular Research: GMR
Heng Ma, Ying-Chih Tseng, Lu-I Chen
Membership determination of text strings has been an important procedure for analyzing textual data of a tremendous amount, especially when time is a crucial factor. Bloom filter has been a well-known approach for dealing with such a problem because of its succinct structure and simple determination procedure. As determination of membership with classification is becoming increasingly desirable, parallel Bloom filters are often implemented for facilitating the additional classification requirement. The parallel Bloom filters, however, tend to produce additional false-positive errors since membership determination must be performed on each of the parallel layers...
2016: Neural Computing & Applications
Lucile Ryckebüsch, Lydia Hernandez, Carole Wang, Jenny Phan, Deborah Yelon
Skeletal muscle morphogenesis depends upon interactions between developing muscle fibers and the extracellular matrix (ECM) that anchors fibers to the myotendinous junction (MTJ). The pathways that organize the ECM and regulate its engagement by cell-matrix adhesion complexes (CMACs) are therefore essential for muscle integrity. Here, we demonstrate the impact of transmembrane protein 2 (tmem2) on cell-matrix interactions during muscle morphogenesis in zebrafish. Maternal-zygotic tmem2 mutants (MZtmem2) exhibit muscle fiber detachment, in association with impaired laminin organization and ineffective fibronectin degradation at the MTJ...
August 15, 2016: Development
Shirley P C Ngai, Alice Y M Jones, Wilson Wai San Tam
BACKGROUND: Tai Chi, a systematic callisthenic exercise first developed in ancient China, involves a series of slow and rhythmic circular motions. It emphasises use of 'mind' or concentration to control breathing and circular body motions to facilitate flow of internal energy (i.e. 'qi') within the body. Normal flow of 'qi' is believed to be essential to sustain body homeostasis, ultimately leading to longevity. The effect of Tai Chi on balance and muscle strength in the elderly population has been reported; however, the effect of Tai Chi on dyspnoea, exercise capacity, pulmonary function and psychosocial status among people with chronic obstructive pulmonary disease (COPD) remains unclear...
June 7, 2016: Cochrane Database of Systematic Reviews
Shagun Bhatia Shah, Ajay Kumar Bhargava, Uma Hariharan, Amit Kumar Mittal, Nitesh Goel, Manish Choudhary
BACKGROUND AND AIMS: Several devices enabling double-lumen tube (DLT) placement for thoracic surgeries are available, but there are no studies for D-blade video laryngoscope-guided DLT insertion. We compared the CMac D-blade videolaryngoscope™ and the Macintosh laryngoscope for DLT endobronchial intubation using parameters of time and attempts required for intubation, glottic view, incidence of complications and haemodynamic changes. METHODS: Prospective, parallel group, randomised controlled clinical trial where sixty American Society of Anesthesiologists I and II patients aged 18-80 years scheduled for thoracic surgeries entailing DLT placement were randomly allocated in two groups based on the laryngoscopic device used for endobronchial intubation...
May 2016: Indian Journal of Anaesthesia
Adnane Boualem, Afef Lemhemdi, Marie-Agnes Sari, Sarah Pignoly, Christelle Troadec, Fadi Abou Choucha, Ilknur Solmaz, Nebahat Sari, Catherine Dogimont, Abdelhafid Bendahmane
Understanding the evolution of sex determination in plants requires the cloning and the characterization of sex determination genes. Monoecy is characterized by the presence of both male and female flowers on the same plant. Andromonoecy is characterized by plants carrying both male and bisexual flowers. In watermelon, the transition between these two sexual forms is controlled by the identity of the alleles at the A locus. We previously showed, in two Cucumis species, melon and cucumber, that the transition from monoecy to andromonoecy results from mutations in 1-aminocyclopropane-1-carboxylic acid synthase (ACS) gene, ACS-7/ACS2...
2016: PloS One
Yi Long, Zhi-Jiang Du, Wei-Dong Wang, Wei Dong
A lower limb assistive exoskeleton is designed to help operators walk or carry payloads. The exoskeleton is required to shadow human motion intent accurately and compliantly to prevent incoordination. If the user's intention is estimated accurately, a precise position control strategy will improve collaboration between the user and the exoskeleton. In this paper, a hybrid position control scheme, combining sliding mode control (SMC) with a cerebellar model articulation controller (CMAC) neural network, is proposed to control the exoskeleton to react appropriately to human motion intent...
2016: Applied Bionics and Biomechanics
Divya Jain, Indu Bala, Komal Gandhi
BACKGROUND: Videolaryngoscopes are increasingly being used in potentially difficult airway. McCoy laryngoscope provides definitive advantage over conventional laryngoscopes in cervical spine patients. The aim of this study was to compare the performance of the CMAC(®) videolaryngoscope with the McCoy Laryngoscope in patients with a cervical collar. MATERIAL AND METHODS: Sample size of at least 22 patients in each group was calculated using Intubation Difficulty Scale (IDS) score as the primary outcome...
January 2016: Journal of Anaesthesiology, Clinical Pharmacology
Andrew B Martin, Jim Lingg, Jeffrey S Lubin
INTRODUCTION: Endotracheal intubation remains one of the most challenging skills in prehospital care. There is a minimal amount of data on the optimal technique to use when managing the airway of an entrapped patient. We hypothesized that use of a blindly placed device would result in both the shortest time to airway management and highest success rate. METHODS: A difficult airway manikin was placed in a cervical collar and secured upside down in an overturned vehicle...
September 2016: Prehospital Emergency Care
Osamu Yokoyama, Yoshihisa Nakayama, Eiji Hoshi
The caudal cingulate motor area (CMAc) and the supplementary motor area (SMA) play important roles in movement execution. The present study examined the neural mechanisms underlying these roles by investigating local field potentials (LFPs) from these areas while monkeys pressed buttons with either their left or right hand. During hand movement, power increases in the high-gamma (80-120 Hz) and theta (3-8 Hz) bands and a power decrease in the beta (12-30 Hz) band were observed in both the CMAc and SMA. High-gamma and beta activity in the SMA predominantly represented contralateral hand movements, whereas activity in the CMAc preferentially represented movement of either hand...
March 2016: Journal of Neurophysiology
Chih-Min Lin, Ming-Shu Yang, Fei Chao, Xiao-Min Hu, Jun Zhang
This paper aims to propose an efficient network and applies it as an adaptive filter for the signal processing problems. An adaptive filter is proposed using a novel interval type-2 fuzzy cerebellar model articulation controller (T2FCMAC). The T2FCMAC realizes an interval type-2 fuzzy logic system based on the structure of the CMAC. Due to the better ability of handling uncertainties, type-2 fuzzy sets can solve some complicated problems with outstanding effectiveness than type-1 fuzzy sets. In addition, the Lyapunov function is utilized to derive the conditions of the adaptive learning rates, so that the convergence of the filtering error can be guaranteed...
October 2016: IEEE Transactions on Neural Networks and Learning Systems
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