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https://www.readbyqxmd.com/read/27906866/inherited-and-acquired-disorders-of-magnesium-homeostasis
#1
Matthias Tilmann Florian Wolf
PURPOSE OF REVIEW: Magnesium (Mg) imbalances are frequently overlooked. Hypermagnesemia usually occurs in preeclamptic women after Mg therapy or in end-stage renal disease patients, whereas hypomagnesemia is more common with a prevalence of up to 15% in the general population. Increasing evidence points toward a role for mild-to-moderate chronic hypomagnesemia in the pathogenesis of hypertension, type 2 diabetes mellitus, and metabolic syndrome. RECENT FINDINGS: The kidneys are the major regulator of total body Mg homeostasis...
November 30, 2016: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/27900961/efficacy-and-safety-of-calcium-acetate-magnesium-carbonate-in-the-treatment-of-hyperphosphatemia-in-dialysis-patients
#2
Imed Helal, Hanene Elkateb, Hafedh Hedri, Malika Hajri, Fethi Ben Hamida
A phosphate binder combining calcium and magnesium offers an interesting therapeutic option to control hyperphosphatemia in dialysis patients. We investigated the effectiveness and tolerance of calcium acetate-magnesium carbonate (Ca-Mg). This is a 16-week prospective study including 16 dialysis patients. After an initial two-week washout period, serum phosphorus (sPho) ≥1.8 mmol/L, serum calcium (sCa) ≤2.6 mmol/L, and serum magnesium ≤1.5 mmol/L were the main inclusion criteria. The initial dose of Ca-Mg depended on sPho level and was titrated for every two weeks to have a sPho ≤ 1...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27875816/serum-magnesium-and-mortality-in-maintenance-hemodialysis-patients
#3
Ling Yu, Han Li, Shi-Xiang Wang
BACKGROUND AND AIM: The study aimed to investigate the potential contributing effect of serum magnesium on mortality in maintenance hemodialysis (MHD) patients. METHODS: The patients receiving regular MHD in March 2013 were involved. Baseline data including clinical data, anthropometrics and biochemical measurement were collected. After being followed for 36 months, the time of death and reason were recorded. RESULTS: One hundred and thirty-five MHD patients were enrolled in the study and analyzed, with mean serum magnesium of 1...
November 23, 2016: Blood Purification
https://www.readbyqxmd.com/read/27643653/hypomagnesemia-is-prevalent-in-patients-undergoing-gynecologic-surgery-by-a-gynecologic-oncologist
#4
Michael A Ulm, Catherine H Watson, Prethi Vaddadi, Jim Y Wan, Joseph T Santoso
OBJECTIVE: The aim of this study was to assess the incidence of and risk factors for hypomagnesemia in patients undergoing gynecologic surgery by a gynecologic oncologist. METHODS: A retrospective chart review was performed on all patients undergoing surgery for gynecologic pathology from July 2011 to July 2015 by a single surgeon. Demographic data, surgical indication, surgery performed, preoperative laboratory values, postoperative laboratory values, and medical history were examined...
September 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27586232/efficacy-of-intravenous-magnesium-in-facilitating-cardioversion-of-atrial-fibrillation
#5
Bharath Rajagopalan, Zubair Shah, Deepika Narasimha, Ashish Bhatia, Chee H Kim, Donald F Switzer, Gregory H Gudleski, Anne B Curtis
BACKGROUND: Low serum magnesium (Mg) levels are associated with an increased risk of atrial fibrillation. Some studies have shown a benefit of Mg in facilitating pharmacological cardioversion. The role of an intravenous infusion of Mg alone in facilitating electric cardioversion is not clear. METHODS AND RESULTS: In a prospective, randomized, double-blind, placebo-controlled trial, we enrolled patients with atrial fibrillation who were scheduled for electric cardioversion...
September 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27467105/a-case-of-iatrogenic-acute-hypermagnesemia-mimicking-sepsis
#6
Abdullah B Akcan, Münevver K Türkmen
No abstract text is available yet for this article.
October 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/27255021/-bowel-obstruction-induced-cholinergic-crisis-with-progressive-respiratory-failure-following-distigmine-bromide-treatment
#7
Kazuki Kobayashi, Hiroshi Sekiguchi, Nobuhiro Sato, Yasuo Hirose
A 54-year-old female experienced rapid respiratory failure while being transported in an ambulance to our emergency department for evaluation and management of constipation and abdominal pain. The patient was on treatment with distigmine bromide for postoperative urination disorder and magnesium oxide for constipation. Increased salivary secretions, diminished respiratory excursion, type 2 respiratory failure (PaCO2 : 65 mmHg), low serum cholinesterase, and hypermagnesemia were detected. Imaging studies revealed that the patient had bilateral aspiration pneumonia, fecal impaction in the rectum, and a distended colon causing ileus...
March 2016: Chūdoku Kenkyū: Chūdoku Kenkyūkai Jun Kikanshi, the Japanese Journal of Toxicology
https://www.readbyqxmd.com/read/27210744/biodegradable-magnesium-mg-implantation-does-not-impose-related-metabolic-disorders-in-rats-with-chronic-renal-failure
#8
Jiali Wang, Jiankun Xu, Waiching Liu, Yangde Li, Ling Qin
Mg and its alloys have been considered as one of the most promising biodegradable medical devices, but it was still unclear whether hypermagnesemia involved health risks would occur in persons with kidney disease due to their deteriorated kidney function for Mg ions excretion from their body. In this study, we established a chronic renal failure (CRF) model in rats induced by adenine administration prior to Mg implantation, aiming to predict if CRF patients are suitable for the use of Mg implants. The results showed that Mg levels in serum, urine, feces and internal organs had no significant changes after Mg implantation for both normal and CRF rats...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27016536/hypomagnesemia-and-mortality-in-patients-admitted-to-intensive-care-unit-a-systematic-review-and-meta-analysis
#9
Sikarin Upala, Veeravich Jaruvongvanich, Karn Wijarnpreecha, Anawin Sanguankeo
BACKGROUND: Reports of mortality due to magnesium dysregulation in the critical care setting are controversial. We performed a systematic review and meta-analysis to evaluate the association between hypomagnesemia and mortality in patients admitted to the intensive care unit. METHODS: Eligible studies assessing the association between hypomagnesemia or hypermagnesemia and mortality in the critical care setting were comprehensively searched in MEDLINE and EMBASE from their inception to September 2015...
July 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/26943694/induction-of-potentially-lethal-hypermagnesemia-ischemic-colitis-and-toxic-megacolon-by-a-preoperative-mechanical-bowel-preparation-report-of-a-case
#10
Masahiko Sugiyama, Eiji Kusumoto, Mitsuhiko Ota, Yasue Kimura, Norifumi Tsutsumi, Eiji Oki, Yoshihisa Sakaguchi, Tetsuya Kusumoto, Koji Ikejiri, Yoshihiko Maehara
A 67-year-old man was diagnosed with rectal cancer. The tumor invaded the subserosal layer, but it was not large, and there was no sign of obstruction. Neo-adjuvant chemotherapy reduced the size of the tumor. The patient was admitted to our hospital for surgery. For mechanical bowel preparation, he ingested 34 g of magnesium citrate (Magcorol P®), but then developed severe shock, a disturbance of consciousness, and acidemia, and he required catecholamines and mechanical ventilation. X-ray, CT, and laboratory tests revealed ischemic colitis, toxic megacolon, and hypermagnesemia (16...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/26915350/an-unusual-yet-mg-nificent-indication-for-hemodialysis
#11
Amar D Bansal, Dan Negoianu, Karen M Warburton
Hypermagnesemia is an uncommon electrolyte abnormality, due to the fact that magnesium toxicity is only seen in the setting of a massive exposure to exogenous magnesium, often in the setting of renal insufficiency. Here, we report a case of severe hypermagnesemia that resulted in complete paralysis that was secondary to Renacidin administration, a rarely used agent used for intra-renal pelvic or intra-vesicular instillation dissolution of struvite stones. The patient also had concurrent acute kidney injury (AKI)...
May 2016: Seminars in Dialysis
https://www.readbyqxmd.com/read/26813770/acute-respiratory-and-renal-failure-due-to-hypermagnesemia-induced-by-counter-laxatives-in-an-elderly-man
#12
Mahmut Alp Karahan, Ahmet Kucuk, Evren Buyukfirat, Funda Yalcin
No abstract text is available yet for this article.
December 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26509017/hypocalcemia-and-hyperkalemia-during-magnesium-infusion-therapy-in-a-pre-eclamptic-patient
#13
Tamer Hudali, Chandandeep Takkar
We present a case of prominent hypocalcemia and hyperkalemia attributed to magnesium infusion in a preeclamptic patient. Iatrogenic hypermagnesemia is an underrecognized cause of hypocalcemia and hyperkalemia. Our report illustrates the effects of magnesium therapy on serum calcium and potassium, necessitating close electrolytes monitoring when used.
October 2015: Clinical Case Reports
https://www.readbyqxmd.com/read/26487446/serum-magnesium-status-in-patients-subjects-with-depression-in-the-city-of-yazd-in-iran-2013-2014
#14
Afsaneh Rajizadeh, Hassan Mozaffari-Khosravi, Mojtaba Yassini-Ardakani, Ali Dehghani
Depression is the most common mental disorder and involves many factors. The regulatory effects of magnesium on N-methyl-D-aspartate (NMDA) channels make it a factor in the treatment of depression. The present study investigated the level of serum magnesium in subjects diagnosed with depression in the city of Yazd in Iran. This cross-sectional study was done from January 2013 to January 2014 on 650 patients with depression who agreed to participate in this study. Diagnosis was made using the Beck Depression Inventory test (BDI-II); those scoring higher than 11 were sent to the medical school laboratory for further testing of serum magnesium levels...
June 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/26404370/magnesium-in-prevention-and-therapy
#15
REVIEW
Uwe Gröber, Joachim Schmidt, Klaus Kisters
Magnesium is the fourth most abundant mineral in the body. It has been recognized as a cofactor for more than 300 enzymatic reactions, where it is crucial for adenosine triphosphate (ATP) metabolism. Magnesium is required for DNA and RNA synthesis, reproduction, and protein synthesis. Moreover, magnesium is essential for the regulation of muscular contraction, blood pressure, insulin metabolism, cardiac excitability, vasomotor tone, nerve transmission and neuromuscular conduction. Imbalances in magnesium status-primarily hypomagnesemia as it is seen more common than hypermagnesemia-might result in unwanted neuromuscular, cardiac or nervous disorders...
September 2015: Nutrients
https://www.readbyqxmd.com/read/26369408/serotonin-5-ht7-receptor-agonist-lp-211-exacerbates-na-k-atpase-mg-2-atpase-imbalances-in-spinal-cord-injured-male-rats
#16
Abbas Norouzi-Javidan, Javad Javanbakht, Fardin Barati, Nahid Fakhraei, Fatemeh Mohammadi, Ahmad Reza Dehpour
BACKGROUND: The observed controversy that N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide (LP-211), a selective serotonin (5-HT7) receptor agonist, may either modify or exacerbate imbalances in serum electrolyte concentrations and renal tissue of spinal cord trauma cases has not been reported yet. The aim of this study was to better understand the effects of a new 5-HT7 receptor agonist, LP-211, on serum electrolyte changes in spinal cord injured- (SCI) rats. METHODS: Sixty male rats were assigned to the following groups: A) Intact (saline as vehicle, 1 ml/kg, i...
2015: Diagnostic Pathology
https://www.readbyqxmd.com/read/26303319/pathophysiology-of-calcium-phosphorus-and-magnesium-dysregulation-in-chronic-kidney-disease
#17
REVIEW
Arnold J Felsenfeld, Barton S Levine, Mariano Rodriguez
Calcium, phosphorus, and magnesium homeostasis is altered in chronic kidney disease (CKD). Hypocalcemia, hyperphosphatemia, and hypermagnesemia are not seen until advanced CKD because adaptations develop. Increased parathyroid hormone (PTH) secretion maintains serum calcium normal by increasing calcium efflux from bone, renal calcium reabsorption, and phosphate excretion. Similarly, renal phosphate excretion in CKD is maintained by increased secretion of fibroblast growth factor 23 (FGF23) and PTH. However, the phosphaturic effect of FGF23 is reduced by downregulation of its cofactor Klotho necessary for binding FGF23 to FGF receptors...
November 2015: Seminars in Dialysis
https://www.readbyqxmd.com/read/26251626/serum-magnesium-concentrations-in-patients-receiving-sodium-picosulfate-and-magnesium-citrate-bowel-preparation-an-assessment-of-renal-function-and-electrocardiographic-conduction
#18
Gerald Bertiger, Edward Jones, David N Dahdal, Dennis C Marshall, Raymond E Joseph
BACKGROUND: We performed a post hoc analysis of two clinical trials to assess whether sodium picosulfate and magnesium (Mg(2+)) citrate (Prepopik(®) [P/MC]), a dual-action bowel preparation for colonoscopy, has an impact on serum Mg(2+) levels and cardiac electrophysiology. Although rare, hypermagnesemia has been reported in patients consuming Mg(2+)-containing cathartics, especially patients who are elderly and have renal impairment. METHODS: Data were analyzed from two prospective, Phase III, randomized, assessor-blinded, active-control, multicenter, pivotal studies that investigated split-dose/day-before P/MC...
2015: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/26250725/dysmagnesemia-in-hospitalized-patients-prevalence-and-prognostic-importance
#19
Wisit Cheungpasitporn, Charat Thongprayoon, Qi Qian
OBJECTIVE: To examine the prevalence of serum magnesium (Mg) alterations and outcomes in hospitalized patients. PATIENTS AND METHODS: All admissions to Mayo Clinic in Rochester, Minnesota, from January 1, 2009, through December 31, 2013 (288,120 patients), were screened. Admission Mg from each unique patient and relevant clinical data were extracted from the institutional electronic database. RESULTS: After excluding patients aged less than 18 years, those without Mg measurement, and readmission episodes, a total of 65,974 patients were studied...
August 2015: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/26205345/admission-serum-magnesium-levels-and-the-risk-of-acute-respiratory-failure
#20
C Thongprayoon, W Cheungpasitporn, N Srivali, S B Erickson
BACKGROUND: The association between admission serum magnesium (Mg) levels and risk of acute respiratory failure (ARF) in hospitalised patients is limited. The aim of this study was to assess the risk of developing ARF in all hospitalised patients with various admission Mg levels. METHODS: This is a single-center retrospective study conducted at a tertiary referral hospital. All hospitalised adult patients who had admission Mg available from January to December 2013 were analysed in this study...
November 2015: International Journal of Clinical Practice
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