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https://www.readbyqxmd.com/read/27923210/study-on-the-interactional-behaviour-of-transition-metal-ions-with-myoglobin-a-detailed-calorimetric-spectroscopic-and-light-scattering-analysis
#1
Amandeep Kaur, Parampaul K Banipal, Tarlok S Banipal
The energetics and the impact on the conformation of heme containing protein myoglobin (Mb) due to the binding of three transition metal ions (Zn(2+), Ni(2+), and Mn(2+)) have been investigated using isothermal titration calorimetry (ITC), dynamic light scattering (DLS), UV-vis, and circular dichroism (CD) spectroscopy under physiological conditions. The binding affinity of the order of 10(4)M(-1) has been observed for all metal ions from calorimetry as well as from absorption spectroscopy. The binding of these metal ions with Mb is a spontaneous process that exposes the hydrophobic groups away from the protein core as exhibited by the negative Gibbs free energy change (ΔG) and positive heat capacity change (ΔCp) values...
November 27, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27923111/evaluation-of-a-pilot-school-based-physical-activity-challenge-for-primary-students
#2
E Passmore, C Donato-Hunt, L Maher, R Havrlant, K Hennessey, A Milat, L Farrell
Issue addressed: Physical inactivity and sedentary behaviour among children are growing public health concerns. The Culture Health Communities Activity Challenge (hereafter known as the Challenge) is a school-based pedometer program in which classes compete to achieve the highest class average daily steps in an 8-week period. The Challenge aims to encourage physical activity in primary school students, with a focus on engaging Aboriginal students. The program was piloted in 15 classes in New South Wales in 2014...
December 2, 2016: Health Promotion Journal of Australia
https://www.readbyqxmd.com/read/27922629/a-collection-of-european-sweet-cherry-phenology-data-for-assessing-climate-change
#3
Bénédicte Wenden, José Antonio Campoy, Julien Lecourt, Gregorio López Ortega, Michael Blanke, Sanja Radičević, Elisabeth Schüller, Andreas Spornberger, Danilo Christen, Hugo Magein, Daniela Giovannini, Carlos Campillo, Svetoslav Malchev, José Miguel Peris, Mekjell Meland, Rolf Stehr, Gérard Charlot, José Quero-García
Professional and scientific networks built around the production of sweet cherry (Prunus avium L.) led to the collection of phenology data for a wide range of cultivars grown in experimental sites characterized by highly contrasted climatic conditions. We present a dataset of flowering and maturity dates, recorded each year for one tree when available, or the average of several trees for each cultivar, over a period of 37 years (1978-2015). Such a dataset is extremely valuable for characterizing the phenological response to climate change, and the plasticity of the different cultivars' behaviour under different environmental conditions...
December 6, 2016: Scientific Data
https://www.readbyqxmd.com/read/27922016/gabaergic-anxiolytic-drug-in-water-increases-migration-behaviour-in-salmon
#4
Gustav Hellström, Jonatan Klaminder, Fia Finn, Lo Persson, Anders Alanärä, Micael Jonsson, Jerker Fick, Tomas Brodin
Migration is an important life-history event in a wide range of taxa, yet many migrations are influenced by anthropogenic change. Although migration dynamics are extensively studied, the potential effects of environmental contaminants on migratory physiology are poorly understood. In this study we show that an anxiolytic drug in water can promote downward migratory behaviour of Atlantic salmon (Salmo salar) in both laboratory setting and in a natural river tributary. Exposing salmon smolt to a dilute concentration of a GABAA receptor agonist (oxazepam) increased migration intensity compared with untreated smolt...
December 6, 2016: Nature Communications
https://www.readbyqxmd.com/read/27921139/reduced-inattention-and-hyperactivity-and-improved-cognition-after-marine-oil-extract-pcso-524%C3%A2-supplementation-in-children-and-adolescents-with-clinical-and-subclinical-symptoms-of-attention-deficit-hyperactivity-disorder-adhd-a-randomised-double-blind-placebo
#5
James D Kean, Jerome Sarris, Andrew Scholey, Richard Silberstein, Luke A Downey, Con Stough
INTRODUCTION: This study investigated the effects of a marine oil extract (PCSO-524®) on inattention, hyperactivity, mood and cognition in children and adolescents. PCSO-524® is a standardised lipid extract of the New Zealand green-lipped mussel and is an inflammatory modulator that inhibits the 5'-lipoxygenase and cyclooxygenase pathways and decreases concentrations of the pro-inflammatory arachidonic acid (AA). METHODS: PCSO-524® or a matched placebo was administered for 14 weeks to 144 participants (123 males/21 females; mean age 8...
December 5, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27920900/polyelectrolyte-coating-on-superparamagnetic-iron-oxide-nanoparticles-as-interface-between-magnetic-core-and-biorelevant-media
#6
Etelka Tombácz, Katalin Farkas, Imre Földesi, Márta Szekeres, Erzsébet Illés, Ildikó Y Tóth, Daniel Nesztor, Tamás Szabó
Nanoparticles do not exist in thermodynamical equilibrium because of high surface free energy, thus they have only kinetic stability. Spontaneous changes can be delayed by designed surface coating. In biomedical applications, superparamagnetic iron oxide nanoparticles (SPIONs) require an optimized coating in order to fulfil the expectation of medicine regulatory agencies and ultimately that of biocompatibility. In this work, we show the high surface reactivity of naked SPIONs due to ≡Fe-OH sites, which can react with H(+)/OH(-) to form pH- and ionic strength-dependent charges...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27920386/does-eutrophication-driven-evolution-change-aquatic-ecosystems
#7
REVIEW
Timothy J Alexander, Pascal Vonlanthen, Ole Seehausen
Eutrophication increases primary production and changes the relative abundance, taxonomic composition and spatial distribution of primary producers within an aquatic ecosystem. The changes in composition and location of resources alter the distribution and flow of energy and biomass throughout the food web. Changes in productivity also alter the physico-chemical environment, which has further effects on the biota. Such ecological changes influence the direction and strength of natural and sexual selection experienced by populations...
January 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27920374/urban-driven-phenotypic-changes-empirical-observations-and-theoretical-implications-for-eco-evolutionary-feedback
#8
REVIEW
Marina Alberti, John Marzluff, Victoria M Hunt
Emerging evidence that cities drive micro-evolution raises the question of whether rapid urbanization of Earth might impact ecosystems by causing systemic changes in functional traits that regulate urban ecosystems' productivity and stability. Intraspecific trait variation-variation in organisms' morphological, physiological or behavioural characteristics stemming from genetic variability and phenotypic plasticity-has significant implications for ecological functions such as nutrient cycling and primary productivity...
January 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27920299/the-type-iii-secretion-system-effector-sptp-of-salmonella-enterica-serovar-typhi
#9
Rebecca Johnson, Alexander Byrne, Cedric N Berger, Elizabeth Klemm, Valerie F Crepin, Gordon Dougan, Gad Frankel
: Salmonella enterica serovars causes gastroenteritis or typhoid fever in humans, with virulence depending on the action of two type III secretion systems (SPI-1 and SPI-2). SptP is a Salmonella SPI-1 effector, involved in mediating recovery of the host cytoskeleton post-infection. SptP requires a chaperone, SicP, for stability and secretion. SptP has 94% identity between S Typhimurium and S Typhi; direct comparison of the protein sequences revealed that S Typhi SptP has numerous amino acid changes within its chaperone-binding domain...
December 5, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27919935/secondary-prevention-lifestyle-interventions-initiated-within-90-days-after-tia-or-minor-stroke-a-systematic-review-and-meta-analysis-of-rehabilitation-programmes
#10
Neil Heron, Frank Kee, Christopher Cardwell, Mark A Tully, Michael Donnelly, Margaret E Cupples
BACKGROUND: Strokes are often preceded by a transient ischaemic attack (TIA) or 'minor' stroke. The immediate period after a TIA/minor stroke is a crucial time to initiate secondary prevention. However, the optimal approach to prevention, including non-pharmacological measures, after TIA is not clear. AIM: To systematically review evidence about the effectiveness of delivering secondary prevention, with lifestyle interventions, in comprehensive rehabilitation programmes, initiated within 90 days of a TIA/minor stroke...
December 5, 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/27919750/mapping-the-functional-connectome-in-traumatic-brain-injury-what-can-graph-metrics-tell-us
#11
Karen Caeyenberghs, Helena Verhelst, Adam Clemente, Peter H Wilson
OBJECTIVE: Traumatic brain injury (TBI) is associated with cognitive and motor deficits, and poses a significant personal, societal, and economic burden. One mechanism by which TBI is thought to affect cognition and behaviour is through changes in functional connectivity. Graph theory is a powerful framework for quantifying topological features of neuroimaging-derived functional networks. The objective of this paper is to review studies examining functional connectivity in TBI with an emphasis on graph theoretical analysis that is proving to be valuable in uncovering network abnormalities in this condition...
December 2, 2016: NeuroImage
https://www.readbyqxmd.com/read/27919442/a-rapid-evidence-review-of-the-effectiveness-and-cost-effectiveness-of-alcohol-control-policies-an-english-perspective
#12
REVIEW
Robyn Burton, Clive Henn, Don Lavoie, Rosanna O'Connor, Clare Perkins, Kate Sweeney, Felix Greaves, Brian Ferguson, Caryl Beynon, Annalisa Belloni, Virginia Musto, John Marsden, Nick Sheron
This paper reviews the evidence for the effectiveness and cost-effectiveness of policies to reduce alcohol-related harm. Policies focus on price, marketing, availability, information and education, the drinking environment, drink-driving, and brief interventions and treatment. Although there is variability in research design and measured outcomes, evidence supports the effectiveness and cost-effectiveness of policies that address affordability and marketing. An adequate reduction in temporal availability, particularly late night on-sale availability, is effective and cost-effective...
December 1, 2016: Lancet
https://www.readbyqxmd.com/read/27919242/reducing-child-abuse-amongst-adolescents-in-low-and-middle-income-countries-a-pre-post-trial-in-south-africa
#13
Lucie Cluver, Franziska Meinck, Alexa Yakubovich, Jenny Doubt, Alice Redfern, Catherine Ward, Nasteha Salah, Sachin De Stone, Tshiamo Petersen, Phelisa Mpimpilashe, Rocio Herrero Romero, Lulu Ncobo, Jamie Lachman, Sibongile Tsoanyane, Yulia Shenderovich, Heidi Loening, Jasmina Byrne, Lorraine Sherr, Lauren Kaplan, Frances Gardner
BACKGROUND: No known studies have tested the effectiveness of child abuse prevention programmes for adolescents in low- or middle-income countries. 'Parenting for Lifelong Health' ( http://tiny.cc/whoPLH ) is a collaborative project to develop and rigorously test abuse-prevention parenting programmes for free use in low-resource contexts. Research aims of this first pre-post trial in South Africa were: i) to identify indicative effects of the programme on child abuse and related outcomes; ii) to investigate programme safety for testing in a future randomised trial, and iii) to identify potential adaptations...
July 13, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27919234/blended-cbt-versus-face-to-face-cbt-a-randomised-non-inferiority-trial
#14
Kim Mathiasen, Tonny E Andersen, Heleen Riper, Annet A M Kleiboer, Kirsten K Roessler
BACKGROUND: Internet based cognitive behavioural therapy (iCBT) has been demonstrated to be cost- and clinically effective. There is a need, however, for increased therapist contact for some patient groups. Combining iCBT with traditional face-to-face (ftf) consultations in a blended format (B-CBT) may produce a new treatment format with multiple benefits from both traditional CBT and iCBT such as individual adaptation, lower costs than traditional therapy, wide geographical and temporal availability, and possibly lower threshold to implementation...
December 5, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27919233/sexual-health-questions-included-in-the-health-behaviour-in-school-aged-children-hbsc-study-an-international-methodological-pilot-investigation
#15
Honor Young, András Költő, Marta Reis, Elizabeth M Saewyc, Nathalie Moreau, Lorraine Burke, Alina Cosma, Béat Windlin, Saoirse Nic Gabhainn, Emmanuelle Godeau
BACKGROUND: This paper describes the methodological developments of the sexual health items included in the Health Behaviour in School-aged Children (HBSC) study since their mandatory inclusion in the study in 2002. The current methodological, ethical and pedagogical challenges in measuring young people's sexual health behaviours are discussed along with the issues associated with the sexual health items introduced to the HBSC study in 2002. The development and piloting of new cross-national items for use in the 2013/14 HBSC data collection are presented and discussed...
December 5, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27919170/validation-of-the-fitbit-one-garmin-vivofit-and-jawbone-up-activity-tracker-in-estimation-of-energy-expenditure-during-treadmill-walking-and-running
#16
Kym Price, Stephen R Bird, Noel Lythgo, Isaac S Raj, Jason Y L Wong, Chris Lynch
OBJECTIVES: To determine the validity of energy expenditure estimation made by the Fitbit One, Garmin Vivofit and Jawbone UP activity trackers during treadmill walking and running. Determining validity of such trackers will inform the interpretation of the data they generate. DESIGN: Cross-sectional study. METHOD: Fourteen adults walked at 0.70, 1.25, 1.80 ms(-1) and ran at 2.22, 2.78, 3.33 ms(-1) on a treadmill wearing a Fitbit One, Garmin Vivofit and Jawbone UP...
December 5, 2016: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/27917785/dipyrone-ameliorates-behavioural-changes-induced-by-unpredictable-chronic-mild-stress-gender-differences
#17
Olcay E Kiroğlu, Kübra E Demirkol, Fatih Berktaş, Arash A Yegani, Ayşegül Kirpik, Erkan Maytalman, Mahmut Ünverdi, Fazilet Aksu
PURPOSE: Antidepressant effects of analgesics have been investigate in both clinical and experimental studies. The purpose of this study was to investigate if the analgesic-antipyretic drug, dipyrone, also had antidepressant-like effects. METHODS: Depression-like effects were investigated in an unpredictable chronic mild stress (UCMS) model in both male and female mice. Cage changes, light-dark cycle reversal, cage tilting, wet floor, empty cage, foreign material on the floor and predator sounds were used to induce light stress at different times for six weeks...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27917743/context-specific-complementary-feeding-recommendations-developed-using-optifood-could-improve-the-diets-of-breast-fed-infants-and-young-children-from-diverse-livelihood-groups-in-northern-kenya
#18
Marieke Vossenaar, Frances A Knight, Alison Tumilowicz, Christine Hotz, Peter Chege, Elaine L Ferguson
OBJECTIVE: To formulate age- and context-specific complementary feeding recommendations (CFR) for infants and young children (IYC) and to compare the potential of filling population-level nutrient gaps using common sets of CFR across age groups. DESIGN: Linear programming was used to develop CFR using locally available and acceptable foods based on livelihood- and age-group-specific dietary patterns observed through 24 h dietary recalls. Within each livelihood group, the nutrient potential of age-group-specific v...
December 5, 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/27917561/how-staff-nurses-perceive-the-impact-of-nurse-managers-leadership-style-in-terms-of-job-satisfaction-a-mixed-method-study
#19
Giuliana Morsiani, Annamaria Bagnasco, Loredana Sasso
AIM: To describe staff nurses' perceptions related to the leadership styles adopted by their nurse managers, identify which leadership style ensured job satisfaction in staff nurses and describe which behaviours nurse managers should change. BACKGROUND: Empirical literature suggests that leadership styles of nurse managers significantly influence staff satisfaction. However, few studies investigate how staff nurses perceive the leadership styles of their nurse managers, and how these impact upon the staff nurses' job satisfaction...
December 5, 2016: Journal of Nursing Management
https://www.readbyqxmd.com/read/27916004/sugars-and-health-a-review-of-current-evidence-and-future-policy
#20
Charlotte Elizabeth Louise Evans
The automation of the process of extracting sugars in the 1900s reduced cost and increased availability of sugars leading to a dramatic rise in consumption, which reached a peak in the 1970s. There are different definitions for sugars not naturally available in foods, and free sugars is the term used by WHO. The epidemiological evidence of the associations between sugars and obesity and type 2 diabetes mellitus is fairly strong and consistent, particularly for sugar sweetened drinks in adults. The Department of Health in the UK and many other countries have recently updated their recommendations for free sugars as a result of this scientific evidence...
December 5, 2016: Proceedings of the Nutrition Society
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