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https://www.readbyqxmd.com/read/29150901/expression-of-the-clock-gene-rev-erb%C3%AE-in-the-brain-controls-the-circadian-organization-of-food-intake-and-locomotor-activity-but-not-daily-variations-of-energy-metabolism
#1
Satish Sen, Stéphanie Dumont, Dominique Sage-Ciocca, Sophie Reibel, Paul de Goede, Andries Kalsbeek, Etienne Challet
The nuclear receptor REV-ERBα is part of the molecular clock mechanism and thought to be involved in a variety of biological processes within metabolically active peripheral tissues as well. To investigate whether Rev-erbα (also known as Nr1d1) in the brain plays a role in the daily variations of energy metabolism, feeding behaviour and the sleep-wake cycle, we studied mice with global (GKO) or brain (BKO) deletion of Rev-erbα. Mice were studied both in a light-dark cycle and constant darkness, and 24-h variations of Respiratory quotient (RQ) and energy expenditure, as well as the temporal patterns of rest-activity and feeding behavior were recorded...
November 18, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29150479/impact-of-variation-in-functions-and-delivery-on-the-effectiveness-of-behavioural-and-mood-management-interventions-for-smoking-cessation-in-people-with-depression-protocol-for-a-systematic-review-and-meta-analysis
#2
Gemma Taylor, Paul Aveyard, Regina Van der Meer, Daniel Toze, Bobby Stuijfzand, David Kessler, Marcus Munafò
INTRODUCTION: Tobacco is the world's leading preventable cause of disease and death. People with depression are twice as likely to smoke and are less responsive to standard tobacco treatments as compared with the general population. A Cochrane systematic review of randomised controlled trials of smoking cessation treatment for smokers with current or historical depression found that adding mood management to usual smoking treatment improved quit rates. However, the review did not examine if variation in intervention delivery or intervention functions impacted on treatment effectiveness...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29149912/trial-to-incentivise-adherence-for-diabetes-triad-study-protocol-for-a-randomised-controlled-trial
#3
Marcel Bilger, Mitesh Shah, Ngiap Chuan Tan, Kaye Louise Howard, Hui Yan Xu, Ecosse Luc Lamoureux, Eric Andrew Finkelstein
BACKGROUND: Many people with diabetes have suboptimal glycaemic control due to not being adherent to their treatment regimen. Behavioural economic theory suggests that the lack of adherence results from the disconnect between the timing of when costs and benefits accrue. One strategy to address this discontinuity is to offer patients a near-term benefit, such as a financial reward. Whereas there is evidence that rewards can improve treatment adherence and sometimes health outcomes, further research is needed to determine whether rewards are more effective when targeting processes or intermediary health outcomes...
November 17, 2017: Trials
https://www.readbyqxmd.com/read/29149787/the-role-of-the-home-environment-in-dementia-care-and-support-systematic-review-of-qualitative-research
#4
Dia Soilemezi, Amy Drahota, John Crossland, Rebecca Stores
Background The domestic home is the preferred site for care provision for people with dementia and their families, therefore creating a dementia and caring friendly home environment is crucial. This systematic review synthesised qualitative studies to explore the role of the home environment and identify potential barriers and facilitators in home dementia care and support to inform future practice and research. Methods A systematic search in 12 databases identified international qualitative literature on perceptions and experiences of community-dwelling people with dementia, family and formal carers regarding the role of the home environment and ways to tackle daily challenges...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29149245/high-dimensional-therapeutic-inference-in-the-focally-damaged-human-brain
#5
Tianbo Xu, Hans Rolf Jäger, Masud Husain, Geraint Rees, Parashkev Nachev
Though consistency across the population renders the extraordinarily complex functional anatomy of the human brain surveyable, the inverse inference-from common functional maps to individual behaviour-is constrained by marked individual deviation from the population mean. Such inference is fundamental to the evaluation of therapeutic interventions in focal brain injury, where the impact of an induced structural change in the brain is quantified by its behavioural consequences, inevitably refracted through the lens of lesion-outcome relations...
November 15, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29148154/incident-reporting-behaviours-following-the-francis-report-a-cross-sectional-survey
#6
Gareth Archer, Alison Colhoun
RATIONALE, AIMS, AND OBJECTIVES: Previous studies have shown a lack of engagement in the reporting process. There is limited evidence about whether attitudes and behaviours of doctors in the UK towards incident reporting have changed following the events at Mid Staffordshire National Health Service Foundation Trust and the recommendations that followed. We conducted a relatively large survey of doctors, aiming to assess whether doctors recognised incidents and reported them accordingly, along with their behaviours towards reporting and their suggestions of how incident reporting may be improved...
November 17, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29147922/the-effect-of-head-to-head-competition-on-behavioural-thermoregulation-thermophysiological-strain-and-performance-during-exercise-in-the-heat
#7
Jo Corbett, Danny K White, Martin J Barwood, Christopher R D Wagstaff, Michael J Tipton, Terry McMorris, Joseph T Costello
BACKGROUND: It has been suggested that pacing is a thermoregulatory behaviour. We investigated the effect of competition on pacing, performance and thermophysiological strain during exercise in the heat and the psychological factors mediating competition effects. METHOD: Eighteen males (maximum oxygen uptake [V O 2max] 3.69 [0.44] L min(-1)) undertook a preliminary 20-km cool (wet-bulb globe temperature [WBGT] 12 °C) cycling time trial (TT) and three experimental 20-km trials (balanced order): (i) cool TT (CoolSolo); (ii) hot (WBGT 26 °C) TT (HotSolo); (iii) hot head-to-head competition (HotH2H)...
November 17, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29147556/mechanism-of-biosurfactant-adsorption-to-oil-water-interfaces-from-millisecond-scale-tensiometry-measurements
#8
Lingling Kong, Kadi Liis Saar, Raphael Jacquat, Liu Hong, Aviad Levin, Hongze Gang, Ruqiang Ye, Bozhong Mu, Tuomas P J Knowles
Many biological molecules are by their nature amphiphilic and have the ability to act as surfactants, stabilizing interfaces between aqueous and immiscible oil phases. In this paper, we explore the adsorption kinetics of surfactin, a naturally occurring cyclic lipopeptide, at hexadecane/water interfaces and compare and contrast its adsorption behaviour with that of synthetic alkyl benzene sulfonate isomers, through direct measurements of changes in interfacial tension upon surfactant adsorption. We access millisecond time resolution in kinetic measurements by making use of droplet microfluidics to probe the interfacial tension of hexadecane droplets dispersed in a continuous water phase through monitoring their deformation when the droplets are exposed to shear flows in a microfluidic channel with regular corrugations...
December 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/29147057/lessons-learnt-during-20-years-of-the-swedish-strategic-programme-against-antibiotic-resistance
#9
Sigvard Mölstad, Sonja Löfmark, Karin Carlin, Mats Erntell, Olov Aspevall, Lars Blad, Håkan Hanberger, Katarina Hedin, Jenny Hellman, Christer Norman, Gunilla Skoog, Cecilia Stålsby-Lundborg, Karin Tegmark Wisell, Christina Åhrén, Otto Cars
Increasing use of antibiotics and rising levels of bacterial resistance to antibiotics are a challenge to global health and development. Successful initiatives for containing the problem need to be communicated and disseminated. In Sweden, a rapid spread of resistant pneumococci in the southern part of the country triggered the formation of the Swedish strategic programme against antibiotic resistance, also known as Strama, in 1995. The creation of the programme was an important starting point for long-term coordinated efforts to tackle antibiotic resistance in the country...
November 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/29146660/changing-physical-activity-behaviour-for-people-with-multiple-sclerosis-protocol-of-a-randomised-controlled-feasibility-trial-istep-ms
#10
Jennifer M Ryan, Jennifer Fortune, Andrea Stennett, Cherry Kilbride, Nana Anokye, Christina Victor, Wendy Hendrie, Mohamed Abdul, Lorraine DeSouza, Grace Lavelle, Debbie Brewin, Lee David, Meriel Norris
INTRODUCTION: Although physical activity may reduce disease burden, fatigue and disability, and improve quality of life among people with multiple sclerosis (MS), many people with MS are physically inactive and spend significant time in sedentary behaviour. Behaviour change interventions may assist people with MS to increase physical activity and reduce sedentary behaviour. However, few studies have investigated their effectiveness using objective measures of physical activity, particularly in the long term...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146659/smoking-and-quit-attempts-during-pregnancy-and-postpartum-a-longitudinal-uk-cohort
#11
Sue Cooper, Sophie Orton, Jo Leonardi-Bee, Emma Brotherton, Laura Vanderbloemen, Katharine Bowker, Felix Naughton, Michael Ussher, Kate E Pickett, Stephen Sutton, Tim Coleman
OBJECTIVES: Pregnancy motivates women to try stopping smoking, but little is known about timing of their quit attempts and how quitting intentions change during pregnancy and postpartum. Using longitudinal data, this study aimed to document women's smoking and quitting behaviour throughout pregnancy and after delivery. DESIGN: Longitudinal cohort survey with questionnaires at baseline (8-26 weeks' gestation), late pregnancy (34-36 weeks) and 3 months after delivery...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146657/a-randomised-controlled-trial-of-a-duodenal-jejunal-bypass-sleeve-device-endobarrier-compared-with-standard-medical-therapy-for-the-management-of-obese-subjects-with-type-2-diabetes-mellitus
#12
Michael Alan Glaysher, Aruchuna Mohanaruban, Christina Gabriele Prechtl, Anthony P Goldstone, Alexander Dimitri Miras, Joanne Lord, Navpreet Chhina, Emanuela Falaschetti, Nicholas Andrew Johnson, Werd Al-Najim, Claire Smith, Jia V Li, Mayank Patel, Ahmed R Ahmed, Michael Moore, Neil Poulter, Stephen Bloom, Ara Darzi, Carel Le Roux, James P Byrne, Julian P Teare
INTRODUCTION: The prevalence of obesity and obesity-related diseases, including type 2 diabetes mellitus (T2DM), is increasing. Exclusion of the foregut, as occurs in Roux-en-Y gastric bypass, has a key role in the metabolic improvements that occur following bariatric surgery, which are independent of weight loss. Endoscopically placed duodenal-jejunal bypass sleeve devices, such as the EndoBarrier (GI Dynamics, Lexington, Massachusetts, USA), have been designed to create an impermeable barrier between chyme exiting the stomach and the mucosa of the duodenum and proximal jejunum...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146445/interplay-between-daily-rhythmic-serum-mediated-bacterial-killing-activity-and-immune-defence-factors-in-rainbow-trout-oncorhynchus-mykiss
#13
Carlo C Lazado, Manuel Gesto, Lone Madsen, Alfred Jokumsen
Circadian rhythm is emerging as an important regulator of immune functions. However, there is a paucity of information on the influence of this biological phenomenon in the antimicrobial factors in teleost fish. This study investigated the dynamics and interplay of serum-mediated bacterial killing activity and immune defence factors throughout the light:dark (LD) cycle in rainbow trout (Oncorhynchus mykiss). The juvenile fish came from two different emergence time fractions (i.e., late and early) that were believed to exhibit behavioural and physiological differences...
November 13, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29145708/managing-non-serious-low-back-pain-in-the-emergency-department-time-for-a-change
#14
Gustavo C Machado, Eileen Rogan, Chris G Maher
Low back pain is a common condition seen in the ED. However, its management in this setting has received relatively little attention and there have been few efforts to develop strategies to improve emergency care of low back pain. In order to ensure that care is appropriately delivered for low back pain patients in the ED, emergency physicians must understand issues of providing low-value care and consider potential solutions to the problem. In this paper, we describe the usual emergency care provided for non-serious low back pain and present possible strategies for restructuring ED practice and approaches for changing physician and patient behaviour...
November 16, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29145140/fluoxetine-modulates-the-transcription-of-genes-involved-in-serotonin-dopamine-and-adrenergic-signalling-in-zebrafish-embryos
#15
V Cunha, P Rodrigues, M M Santos, P Moradas-Ferreira, M Ferreira
Neurotransmitters pathways in fish and mammals are phylogenetically conserved. Therefore, the environmental presence of psychopharmaceuticals, such as fluoxetine (FLU), are likely to interact with fish serotonergic, dopaminergic and adrenergic systems, affecting their response and associated biological functions. Hence, the present work aimed at evaluating the effects of FLU in the transcription of genes involved in serotonin, dopamine and adrenergic transporters and receptors signalling in early stages of Danio rerio development...
October 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/29144977/birthplace-in-australia-processes-and-interactions-during-the-intrapartum-transfer-of-women-from-planned-homebirth-to-hospital
#16
Deborah Fox, Athena Sheehan, Caroline Homer
OBJECTIVE: the aim of the study was to explore the views and experiences of women, midwives and obstetricians on the intrapartum transfer of women from planned homebirth to hospital in Australia. DESIGN: a Constructivist Grounded Theory approach was taken, to conceptualise the social interactions and processes grounded in the data. SETTING: urban and regional areas in four states of south-eastern Australia. PARTICIPANTS: semi-structured qualitative interviews were conducted with 36 women, midwives and obstetricians who had experienced an intrapartum homebirth transfer within three years prior to the interview...
November 2, 2017: Midwifery
https://www.readbyqxmd.com/read/29143595/why-nature-prevails-over-nurture-in-the-making-of-the-elite-athlete
#17
Evelina Georgiades, Vassilis Klissouras, Jamie Baulch, Guan Wang, Yannis Pitsiladis
While the influence of nature (genes) and nurture (environment) on elite sporting performance remains difficult to precisely determine, the dismissal of either as a contributing factor to performance is unwarranted. It is accepted that a complex interaction of a combination of innumerable factors may mold a talented athlete into a champion. The prevailing view today is that understanding elite human performance will require the deciphering of two major sources of individual differences, genes and the environment...
November 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29143443/multiscale-characterisation-of-cortical-bone-composition-microstructure-and-nanomechanical-properties-in-experimentally-induced-osteoporosis
#18
Furqan A Shah, Adrian Stoica, Carina Cardemil, Anders Palmquist
Cortical bone plays a vital role in determining overall bone strength. We investigate the structural, compositional, and nanomechanical properties of cortical bone following ovariectomy (OVX) of 12 week old Sprague Dawley rats, since this animal model is frequently employed to evaluate the performance of implantable biomaterials in compromised bone healing conditions. Morphological parameters and material properties of bone in the geometrical centre of the femoral cortex were investigated four and eight weeks post-OVX and in unoperated controls (Ctrl), using X-ray micro-computed tomography, backscattered electron scanning electron microscopy, Raman spectroscopy, and nanoindentation...
November 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29142254/a-soft-selective-sweep-during-rapid-evolution-of-gentle-behaviour-in-an-africanized-honeybee
#19
Arian Avalos, Hailin Pan, Cai Li, Jenny P Acevedo-Gonzalez, Gloria Rendon, Christopher J Fields, Patrick J Brown, Tugrul Giray, Gene E Robinson, Matthew E Hudson, Guojie Zhang
Highly aggressive Africanized honeybees (AHB) invaded Puerto Rico (PR) in 1994, displacing gentle European honeybees (EHB) in many locations. Gentle AHB (gAHB), unknown anywhere else in the world, subsequently evolved on the island within a few generations. Here we sequence whole genomes from gAHB and EHB populations, as well as a North American AHB population, a likely source of the founder AHB on PR. We show that gAHB retains high levels of genetic diversity after evolution of gentle behaviour, despite selection on standing variation...
November 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29142113/chromatic-and-achromatic-monocular-deprivation-produce-separable-changes-of-eye-dominance-in-adults
#20
Jiawei Zhou, Alexandre Reynaud, Yeon Jin Kim, Kathy T Mullen, Robert F Hess
Temporarily depriving one eye of its input, in whole or in part, results in a transient shift in eye dominance in human adults, with the patched eye becoming stronger and the unpatched eye weaker. However, little is known about the role of colour contrast in these behavioural changes. Here, we first show that the changes in eye dominance and contrast sensitivity induced by monocular eye patching affect colour and achromatic contrast sensitivity equally. We next use dichoptic movies, customized and filtered to stimulate the two eyes differentially...
November 29, 2017: Proceedings. Biological Sciences
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