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https://www.readbyqxmd.com/read/29615986/whole-genome-sequencing-and-multiplex-qpcr-methods-to-identify-campylobacter-jejuni-encoding-cst-ii-or-cst-iii-sialyltransferase
#1
Jason M Neal-McKinney, Kun C Liu, Karen C Jinneman, Wen-Hsin Wu, Daniel H Rice
Campylobacter jejuni causes more than 2 million cases of gastroenteritis annually in the United States, and is also linked to the autoimmune sequelae Guillan-Barre syndrome (GBS). GBS often results in flaccid paralysis, as the myelin sheaths of nerve cells are degraded by the adaptive immune response. Certain strains of C. jejuni modify their lipooligosaccharide (LOS) with the addition of neuraminic acid, resulting in LOS moieties that are structurally similar to gangliosides present on nerve cells. This can trigger GBS in a susceptible host, as antibodies generated against C...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29606298/effect-of-beta-blocker-dose-on-mortality-after-acute-coronary-syndrome
#2
Sergio Raposeiras-Roubin, Emad Abu-Assi, Berenice Caneiro-Queija, Rafael Cobas-Paz, Lucía Rioboo-Lestón, Cristina García Rodríguez, Cruz Giraldez Lemos, María Blanco Vidal, Beatriz Ogando Guillán, Isabel Pérez Martínez, Emilio Paredes-Galán, Víctor Jimenez-Díaz, Jose Antonio Baz-Alonso, Francisco Calvo-Iglesias, Andrés Íñiguez-Romo
INTRODUCTION: Beta-blocker doses that have been shown to be effective in randomized clinical trials are not commonly used in daily clinical practice. The aim of this study was to analyze whether there is a prognostic benefit of high rather than low doses of beta-blockers after an acute coronary syndrome (ACS). METHODS: In this retrospective cohort study, 2092 ACS patients discharged from hospital between June 2013 and January 2016 were classified according to the beta-blocker dose prescribed: high dose (≥50% of the target dose tested in clinical trials) and low dose (<50%)...
March 30, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29411644/genitourinary-syndrome-of-menopause-prevalence-and-quality-of-life-in-spanish-postmenopausal-women-the-genisse-study
#3
E Moral, J L Delgado, F Carmona, B Caballero, C Guillán, P M González, J Suárez-Almarza, S Velasco-Ortega, C Nieto
OBJECTIVE: To determine the prevalence of genitourinary syndrome of menopause (GSM) and urogynecological conditions associated with menopause, and to evaluate the impact of GSM on quality of life in a cohort of Spanish postmenopausal women. METHODS: Multicenter, cross-sectional, and observational study involving 430 women. RESULTS: The prevalence of GSM was 70%. GSM was diagnosed in 60.2% of women with no known diagnosis of vulvovaginal atrophy or GSM...
February 7, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29365670/comorbidity-and-sex-differences-among-patients-with-ischemic-heart-disease-currently-smokers
#4
José Antonio Díaz-Peromingo, Cristina Macía-Rodríguez, Vanesa Alende-Castro, Emilio Páez-Guillán, Alba García-Villafranca, Arturo González-Quintela
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29241768/zika-virus-the-transboundary-pathogen-from-mosquito-and-updates
#5
REVIEW
Weili Kong, Hengtao Li, Jian Zhu
Zika virus (ZIKV) is a mosquito-borne flavivirus that was relatively obscure until outbreaks started in 2013. ZIKV is associated with neurological manifestations such as Guillan-Barrè Syndrome in adult and microcephaly in the newborn population. Although the majority of disease mechanisms of ZIKV is unclear, some information was updated with new scientific evidence. Currently, there are no approved drugs or vaccine that can be used for therapy during ZIKV infection. Based on the transmission mechanism of ZIKV, vector control and safe sex seem to be the most effective available preventive measures against ZIKV spread...
January 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29178941/s100a8-a9-and-srage-kinetic-after-polytrauma-an-explorative-observational-study
#6
Philippe Joly, John C Marshall, Philippe A Tessier, Chantal Massé, Nathalie Page, Anne Julie Frenette, François Khazoom, Soazig Le Guillan, Yves Berthiaume, Emmanuel Charbonney
BACKGROUND: Following tissue injury after trauma, the activation of innate immune pathways results in systemic inflammation, organ failure and an increased risk of infections. The objective of this study was to characterize the kinetics of the S100A8/S100A9 complex, a new-recognized alarmin, as well as its soluble receptor sRAGE, over time after trauma as potential early biomarkers of the risk of organ damage. METHODS: We collected comprehensive data from consenting patients admitted to an ICU following severe trauma...
November 25, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28706599/acute-fulminant-uremic-neuropathy-following-coronary-angiography-mimicking-guillain-barre-syndrome
#7
Kumari Priti, Bhanwar Ranwa
A 55-year-old diabetic woman suffered a posterior wall ST-elevation myocardial infarction. She developed contrast-induced nephropathy following coronary angiography. Acute fulminant uremic neuropathy was precipitated which initially mimicked Guillan-Barre Syndrome, hence reported.
April 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/28694624/neuropsychiatric-manifestations-of-scrub-typhus
#8
REVIEW
Sanjay K Mahajan, Sanyam K Mahajan
Scrub typhus is caused by Orientia tsutsugamushi characterized by focal or disseminated vasculitis and perivasculitis which may involve the lungs, heart, liver, spleen and central nervous system. It was thought to have been eradicated from India. Recently it is being reported from many areas of India. The clinical picture and severity of the symptoms varies widely. The neurological manifestations of scrub typhus are not uncommon but are diverse. Meningoencephalitis is classical manifestation of scrub typhus but cerebellitis, cranial nerve palsies, plexopathy, transverse myelitis, neuroleptic malignant syndrome and Guillan-Barré syndrome are other manifestations reported in literature...
July 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28448605/vasopressor-use-following-traumatic-injury-a-single-center-retrospective-study
#9
Mathieu Hylands, Marie-Pier Godbout, Sandeep K Mayer, William D Fraser, Alain Vanasse, Marc-André Leclair, Alexis F Turgeon, François Lauzier, Emmanuel Charbonney, Vincent Trottier, Tarek S Razek, André Roy, Frédérick D'Aragon, Emilie Belley-Côté, Andrew G Day, Soazig Le Guillan, Robert Sabbagh, François Lamontagne
OBJECTIVES: Vasopressors are not recommended by current trauma guidelines, but recent reports indicate that they are commonly used. We aimed to describe the early hemodynamic management of trauma patients outside densely populated urban centers. METHODS: We conducted a single-center retrospective cohort study in a Canadian regional trauma center. All adult patients treated for traumatic injury in 2013 who died within 24 hours of admission or were transferred to the intensive care unit were included...
2017: PloS One
https://www.readbyqxmd.com/read/28444557/overview-on-the-current-status-of-zika-virus-pathogenesis-and-animal-related-research
#10
REVIEW
Shashank S Pawitwar, Supurna Dhar, Sneham Tiwari, Chet Raj Ojha, Jessica Lapierre, Kyle Martins, Alexandra Rodzinski, Tiyash Parira, Iru Paudel, Jiaojiao Li, Rajib Kumar Dutta, Monica R Silva, Ajeet Kaushik, Nazira El-Hage
There is growing evidence that Zika virus (ZIKV) infection is linked with activation of Guillan-Barré syndrome (GBS) in adults infected with the virus and microcephaly in infants following maternal infection. With the recent outpour in publications by numerous research labs, the association between microcephaly in newborns and ZIKV has become very apparent in which large numbers of viral particles were found in the central nervous tissue of an electively aborted microcephalic ZIKV-infected fetus. However, the underlying related mechanisms remain poorly understood...
September 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28102025/the-direct-referral-to-endovascular-center-criteria-a-proposal-for-pre-hospital-evaluation-of-acute-stroke-in-the-madrid-stroke-network
#11
J Rodríguez-Pardo, B Fuentes, M Alonso de Leciñana, Á Ximénez-Carrillo, G Zapata-Wainberg, J Álvarez-Fraga, F J Barriga, L Castillo, J Carneado-Ruiz, J Díaz-Guzman, J Egido-Herrero, A de Felipe, J Fernández-Ferro, L Frade-Pardo, Á García-Gallardo, A García-Pastor, A Gil-Núñez, C Gómez-Escalonilla, M Guillán, Y Herrero-Infante, J Masjuan-Vallejo, M Á Ortega-Casarrubios, J Vivancos-Mora, E Díez-Tejedor
BACKGROUND AND PURPOSE: For patients with acute ischaemic stroke due to large-vessel occlusion, it has recently been shown that mechanical thrombectomy (MT) with stent retrievers is better than medical treatment alone. However, few hospitals can provide MT 24 h/day 365 days/year, and it remains unclear whether selected patients with acute stroke should be directly transferred to the nearest MT-providing hospital to prevent treatment delays. Clinical scales such as Rapid Arterial Occlusion Evaluation (RACE) have been developed to predict large-vessel occlusion at a pre-hospital level, but their predictive value for MT is low...
March 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28034744/extended-substrate-specificity-and-first-potent-irreversible-inhibitor-activity-based-probe-design-for-zika-virus-ns2b-ns3-protease
#12
Wioletta Rut, Linlin Zhang, Paulina Kasperkiewicz, Marcin Poreba, Rolf Hilgenfeld, Marcin Drąg
Zika virus is spread by Aedes mosquitoes and is linked to acute neurological disorders, especially to microcephaly in newborn children and Guillan-Barré Syndrome. The NS2B-NS3 protease of this virus is responsible for polyprotein processing and therefore considered an attractive drug target. In this study, we have used the Hybrid Combinatorial Substrate Library (HyCoSuL) approach to determine the substrate specificity of ZIKV NS2B-NS3 protease in the P4-P1 positions using natural and a large spectrum of unnatural amino acids...
March 2017: Antiviral Research
https://www.readbyqxmd.com/read/27800000/spontaneous-spinal-epidural-hematoma-coexisting-guillan-barr%C3%A3-syndrome-in-a-child-a-case-report
#13
Chi Hyung Lee, Geun Sung Song, Young Ha Kim, Dong Wuk Son, Sang Weon Lee
Spontaneous spinal epidural hematoma (SSEH) has been reported as a rare cause of spinal cord compression, especially in children. Clinical features are usually nonspecific, although cervicothoracic location of hematoma could be presented with progressive paraplegia. Guillian-Barré syndrome (GBS) is clinically defined as an acute peripheral neuropathy causing progressive limb weakness. Because SSEH and GBS have very similar signs and symptoms, SSEH could be misdiagnosed as GBS. Nevertheless, they can be presented together...
September 2016: Korean Journal of Spine
https://www.readbyqxmd.com/read/27721110/an-updated-review-of-zika-virus
#14
REVIEW
Abdelrahman Ibrahim Abushouk, Ahmed Negida, Hussien Ahmed
The current outbreak of Zika virus (ZIKV) in South America is one of the most serious public health emergencies since the Ebola outbreak of West Africa [2014]. ZIKV belongs to the flaviviridae family and has two lineages (Asian and African). The virus was first discovered in Uganda [1947] and the first human infection was identified in Nigeria [1952]. The current epidemic is the third of its type after that of Yap Island, Micronesia [2007] and French Polynesia [2013]. Phylogenetic studies revealed that the current strain shares about 99...
November 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27477576/guillan-barr%C3%A3-syndrome-following-scrub-typus-two-case-reports
#15
REVIEW
Katsuya Sakai, Nobuyuki Ishii, Yuka Ebihara, Hitoshi Mochizuki, Kazutaka Shiomi, Masamitsu Nakazato
Case 1: A 66-year-old man was admitted because of progressive gait disturbance and dysphagia after developing red rash. He was diagnosed as Guillain-Barré syndrome (GBS) and treated by intravenous immunoglobulin therapy (IVIg). Two weeks later, he could swallow and walk without any abnormalities. Case 2: A 58-year-old woman was admitted because of gait disturbance, bilateral peripheral facial nerve palsies, and respiratory failure one week after developing fever and rash. She was diagnosed as GBS and treated with IVIg...
August 31, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27105768/the-syndrome-of-transient-headache-and-neurological-deficits-with-cerebrospinal-fluid-lymphocytosis-mimicking-an-acute-stroke
#16
M Guillan, A DeFelipe-Mimbrera, A Alonso-Canovas, M C Matute, R Vera, A Cruz-Culebras, N Garcia-Barragan, J Masjuan
BACKGROUND AND PURPOSE: The syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL) can present as sudden onset of focal neurological deficits which are clinically and radiologically indistinguishable from an ischaemic stroke. Its diagnosis requires a lumbar puncture (LP), which contraindicates intravenous thrombolytic therapy (IV-tPA). METHODS: All patients referred to our stroke centre as a stroke code resulting in a final diagnosis of HaNDL syndrome from June 2005 to June 2015 were retrospectively analysed...
July 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/26290856/outcomes-of-traumatic-aortic-injury-in-a-primary-open-surgical-approach-paradigm
#17
Jessica Forcillo, Michel Philie, Andrea Ojanguren, Soazig Le Guillan, Alain Verdant, Philippe Demers, Yoan Lamarche
BACKGROUND: Multiple classifications can be used to define the magnitude of aortic injury. The Vancouver Classification (VC) is a new and simplified computed tomography-based Blunt Aortic Injury (BAI) grading system correlating with clinical outcomes. OBJECTIVES: The objectives of this study are: 1) to describe the severity of aortic injury in a center with a predominantly surgical approach to BAI; 2) to correlate the severity of aortic trauma to hospital survival rate and rate of adverse events according to the type of interventions performed during the hospital stay; and 3) to evaluate VC...
May 2015: Trauma Monthly
https://www.readbyqxmd.com/read/26266339/the-usefulness-of-immunotherapy-in-pediatric-neurodegenerative-disorders-a-systematic-review-of-literature-data
#18
REVIEW
Giovanna Vitaliti, Omidreza Tabatabaie, Nassim Matin, Caterina Ledda, Piero Pavone, Riccardo Lubrano, Agostino Serra, Paola Di Mauro, Salvatore Cocuzza, Raffaele Falsaperla
Immunotherapeutic strategies to treat neurodegenerative disorders have inspired the scientific community. The aim of our review is to address the translational aspects of neuroimmunology to describe the efficacy of immunotherapy in the treatment of pediatric neurodegenerative disorders. In the studies we analyzed IVIG were found to be efficient in the treatment of post-streptococcal neurodegenerative disorders, even if in PANDAS, plasma-exchange (PE) showed a higher efficiency. IVIG were also successfully used in ADEM and Guillan-Barré syndrome...
2015: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/25955374/about-an-unusual-association-of-guillan-barre-syndrome-and-pulmonary-tuberculosis
#19
Hafaoua Daghfous, Haifa Zaibi, Fatma Tritar
No abstract text is available yet for this article.
January 2015: La Tunisie Médicale
https://www.readbyqxmd.com/read/25926070/simulation-in-neurology
#20
Giuseppe Micieli, Anna Cavallini, Paola Santalucia, Gianfranco Gensini
Simulation is a frontier for disseminating knowledge in almost all the fields of medicine and it is attracting growing interest because it offers a means of developing new teaching and training models, as well as of verifying what has been learned in a critical setting that simulates clinical practice. The role of simulation in neurology, until now limited by the obvious physical limitations of the dummies used to train students and learners, is now increasing since, today, it allows anamnestic data to be related to the instrumental evidence necessary for diagnosis and therapeutic decision-making, i...
October 2015: Neurological Sciences
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