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https://www.readbyqxmd.com/read/29353289/the-new-agreement-of-the-international-riga-consensus-conference-on-nasal-airway-function-tests
#1
K Vogt, G Bachmann-Harildstad, A Lintermann, A Nechyporenko, F Peters, K D Wernecke
The report reflects an agreement based on the consensus conference of the International Standardization Committee on the Objective Assessment of the Nasal Airway in Riga, 2nd Nov. 2016. The aim of the conference was to address the existing nasal airway function tests and to take into account physical, mathematical and technical correctness as a base of international standardization as well as the requirements of the Council Directive 93/42/EEC of 14 June 1993 concerning medical devices. Rhinomanometry, acoustic rhinometry, peak nasal inspiratory flow, Odiosoft-Rhino, optical rhinometry, 24-h measurements, computational fluid dynamics, nasometry and the mirrow test were evaluated for important diagnostic criteria, which are the precision of the equipment including calibration and the software applied; validity with sensitivity, specificity, positive and negative predictive values, reliability with intra-individual and inter-individual reproducibility and responsiveness in clinical studies...
January 21, 2018: Rhinology
https://www.readbyqxmd.com/read/29345622/position-paper-on-nasal-obstruction-evaluation-and-treatment
#2
REVIEW
A Valero, A M Navarro, A Del Cuvillo, I Alobid, J R Benito, C Colás, G de Los Santos, R Fernández Liesa, A García-Lliberós, R González-Pérez, A Izquierdo-Domínguez, A Jurado-Ramos, M M Lluch-Bernal, J R Montserrat Gili, J Mullol, A Puiggròs Casas, M C Sánchez-Hernández, F Vega, J M Villacampa, M Armengot-Carceller, M T Dordal
Nasal obstruction (NO) is defined as the subjective perception of discomfort or difficulty in the passage of air through the nostrils. It is a common reason for consultation in primary and specialized care, and it may affect up to 30-40% of the population. It affects the quality of life (it especially disturbs sleep) and lowers work efficiency. The aim of this document is to agree on how to treat NO, establish a methodology for evaluating and diagnosing it, and define an individualized approach to its treatment...
January 18, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29337804/the-association-between-ventilator-dyssynchrony-delivered-tidal-volume-and-sedation-using-a-novel-automated-ventilator-dyssynchrony-detection-algorithm
#3
Peter D Sottile, David Albers, Carrie Higgins, Jeffery Mckeehan, Marc M Moss
OBJECTIVE: Ventilator dyssynchrony is potentially harmful to patients with or at risk for the acute respiratory distress syndrome. Automated detection of ventilator dyssynchrony from ventilator waveforms has been difficult. It is unclear if certain types of ventilator dyssynchrony deliver large tidal volumes and whether levels of sedation alter the frequency of ventilator dyssynchrony. DESIGN: A prospective observational study. SETTING: A university medical ICU...
February 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29330991/diaphyseal-nutrient-foramina-in-dried-human-adult-long-bones-of-lower-limb-in-pakistan
#4
Ejaz Afzal, Fatima Sherin, Omair Khan, Noaman Hussain Siddiqui
BACKGROUND: osteogenesis needs circulation of blood in the bones. Bone growth, repair of fracture, maintenance of bone vitality and other injures also need blood circulation in proper way. Blood is allowed to flow via holes in the diaphysis, which are called as nutrient foramina. METHODS: The crosssectional study was done in the department of Anatomy, Ayub and Khyber Medical College (Osteology Sections). The aim was to observe diaphyseal nutrient foramina in the human long bones of the lower limb...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29303444/reductions-in-brain-pericytes-are-associated-with-arteriovenous-malformation-vascular-instability
#5
Ethan A Winkler, Harjus Birk, Jan-Karl Burkhardt, Xiaolin Chen, John K Yue, Diana Guo, W Caleb Rutledge, George F Lasker, Carlene Partow, Tarik Tihan, Edward F Chang, Hua Su, Helen Kim, Brian P Walcott, Michael T Lawton
OBJECTIVE Brain arteriovenous malformations (bAVMs) are rupture-prone tangles of blood vessels with direct shunting of blood flow between arterial and venous circulations. The molecular and/or cellular mechanisms contributing to bAVM pathogenesis and/or destabilization in sporadic lesions have remained elusive. Initial insights into AVM formation have been gained through models of genetic AVM syndromes. And while many studies have focused on endothelial cells, the contributions of other vascular cell types have yet to be systematically studied...
January 5, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29285698/dynamics-and-sources-of-pharmaceutically-active-compounds-in-a-coastal-mediterranean-river-during-heavy-rains
#6
Brice Reoyo-Prats, Dominique Aubert, Amélie Sellier, Benoit Roig, Carmen Palacios
Concentrations of pharmaceutically active compounds (PACs) in freshwater systems depend on numerous factors such as land use and hydrometeorological conditions. In the Mediterranean, heavy rain events are of particular importance as they highly influence the concentration of micropollutants found in freshwater and are a source of recurrent first foul flushes due to combined sewer overflows (CSOs). In this study, we seek to assess the dynamics of pharmaceuticals during storm events in coastal Mediterranean rivers at a fine scale and to determine their contribution to multicontamination phenomena owing to CSOs...
December 28, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29281498/continuous-and-quantitative-purification-of-t-cell-subsets-for-cell-therapy-manufacturing-using-magnetic-ratcheting-cytometry
#7
Coleman Murray, Edward Pao, Andrew Jann, Da Eun Park, Dino Di Carlo
T-cell-based immunotherapies represent a growing medical paradigm that has the potential to revolutionize contemporary cancer treatments. However, manufacturing bottlenecks related to the enrichment of therapeutically optimal T-cell subpopulations from leukopak samples impede scale-up and scale-out efforts. This is mainly attributed to the challenges that current cell purification platforms face in balancing the quantitative sorting capacity needed to isolate specific T-cell subsets with the scalability to meet manufacturing throughputs...
December 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/29276983/uplc-ms-ms-method-for-the-simultaneous-quantification-of-sofosbuvir-sofosbuvir-metabolite-gs-331007-and-daclatasvir-in-plasma-of-hiv-hcv-co-infected-patients
#8
Stefania Notari, Massimo Tempestilli, Gabriele Fabbri, Raffaella Libertone, Andrea Antinori, Adriana Ammassari, Chiara Agrati
Direct-acting antiviral agents (DAAs) represent the major advance in hepatitis C virus (HCV) infection treatment leading to extremely high eradication rates in HCV mono- and HIV/HCV co-infected patients. In this scenery, availability of Therapeutic Drug Monitoring (TDM) is of interest to assess plasma concentrations to prevent either therapeutic failure due to suboptimal medication adherence and drug-drug interactions or avoid adverse events. Aim of this study was to develop and validate an Ultra-Performance Liquid Chromatography Mass Spectrometry (UPLC-MS/MS) method for the simultaneous quantification of sofosbuvir, sofosbuvir metabolite (GS-331007), and daclatasvir in human plasma...
December 12, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29200573/neural-effects-of-transcranial-direct-current-stimulation-in-schizophrenia-a-case-study-using-functional-near-infrared-spectroscopy
#9
S Trevor Taylor, Harleen Chhabra, Vanteemar S Sreeraj, Venkataram Shivakumar, Sunil V Kalmady, Ganesan Venkatasubramanian
Schizophrenia is a severe neuropsychiatric disorder characterized by delusions, hallucinations, behavioral symptoms, and cognitive deficits. Roughly, 70%-80% of schizophrenia patients experience auditory verbal hallucinations (AVHs), with 25%-30% demonstrating resistance to conventional antipsychotic medications. Studies suggest a promising role for add-on transcranial direct current stimulation (tDCS) in the treatment of medication-refractory AVHs. The mechanisms through which tDCS could be therapeutic in such cases are unclear, but possibly involve neuroplastic effects...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29197316/developing-a-mass-casualty-surge-capacity-protocol-for-emergency-medical-services-to-use-for-patient-distribution
#10
Samuel E Shartar, Brooks L Moore, Lori M Wood
OBJECTIVES: Metropolitan areas must be prepared to manage large numbers of casualties related to a major incident. Most US cities do not have adequate trauma center capacity to manage large-scale mass casualty incidents (MCIs). Creating surge capacity requires the distribution of casualties to hospitals that are not designated as trauma centers. Our objectives were to extrapolate MCI response research into operational objectives for MCI distribution plan development; formulate a patient distribution model based on research, hospital capacities, and resource availability; and design and disseminate a casualty distribution tool for use by emergency medical services (EMS) personnel to distribute patients to the appropriate level of care...
December 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/29183758/evaluation-of-intrinsic-and-acquired-immune-cells-infiltration-in-kidney-and-spleen-of-the-mice-infected-with-systemic-candidiasis-and-treated-with-chloroform-fraction-of-zataria-multiflora-boiss
#11
Mansour Bayat, Niloofar Hassannejad, Hadi Ghazanfari
BACKGROUND AND AIMS: Despite the use of antifungal drugs, the visceral candidiasis is associated with a high mortality rate. The aims of this study were an evaluation of intrinsic and acquired immune cells infiltration in kidney and spleen of the mice infected with systemic candidiasis and treated with chloroform fraction of Zataria Multiflora Boiss. MATERIALS AND METHODS: Candida albicans (C. albicans) ATCC10231 clinical standard strain was isolated. C. albicans LD50 was determined...
November 25, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29174971/a-self-powered-biosensing-device-with-an-integrated-hybrid-biofuel-cell-for-intermittent-monitoring-of-analytes
#12
Dominika Majdecka, Sylwia Draminska, Dariusz Janusek, Paweł Krysinski, Renata Bilewicz
In this work, we propose an integrated self-powered sensing system, driven by a hybrid biofuel cell (HBFC) with carbon paper discs coated with multiwalled carbon nanotubes. The sensing system has a biocathode made from laccase or bilirubin oxidase, and the anode is made from a zinc plate. The system includes a dedicated custom-built electronic control unit for the detection of oxygen and catechol analytes, which are central to medical and environmental applications. Both the HBFC and sensors, operate in a mediatorless direct electron transfer mode...
November 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29165122/decreased-blood-pressure-associated-with-in-vehicle-exposure-to-carbon-monoxide-in-korean-volunteers
#13
Geon-Woo Lee, Mun-Joo Bae, Ji-Yeon Yang, Jung-Woo Son, Jae-Lim Cho, Sang-Gyu Lee, Bo-Mi Jang, Hyun-Woo Lee, Jong-Soon Lim, Dong-Chun Shin, Young-Wook Lim
BACKGROUND: Carbon monoxide (CO) is one of the primary components of emissions from light-duty vehicles, and reportedly comprises 77% of all pollutants emitted in terms of concentration. Exposure to CO aggravates cardiovascular disease and causes other health disorders. The study was aimed to assess the negative effects by injecting different amounts of CO concentration directly to human volunteers boarding in the car. METHODS: Human volunteers were exposed to CO concentrations of 0, 33...
April 5, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29161170/examining-the-implementation-of-collaborative-competencies-in-a-critical-care-setting-key-challenges-for-enacting-competency-based-education
#14
Joanne Goldman, Simon Kitto, Scott Reeves
Interprofessional collaboration is recognised as an important factor in improving patient care in intensive care units (ICUs). Competency frameworks, and more specifically interprofessional competency frameworks, are a key strategy being used to support the development of attitudes, knowledge, skills, and behaviours needed for an interprofessional approach to care. However, evidence for the application of competencies is limited. This study aimed to extend our empirically based understanding of the significance of interprofessional competencies to actual clinical practice in an ICU...
November 21, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29143074/-additional-emergency-medical-measures-in-trauma-associated-cardiac-arrest
#15
B Ondruschka, C Baier, J Dreßler, A Höch, M Bernhard, C Kleber, C Buschmann
INTRODUCTION: More than half of all traumatic deaths happen in prehospital settings. Until now, there have been no long-term studies examining the actual additive treatment during trauma-associated cardiopulmonary resuscitation (tCPR), including pleural decompression, pericardiocentesis, tourniquets and external stabilization of the pelvis. The present cohort study evaluated forensic autopsy reports of trauma deaths occurring at the scene with respect to additive actions in preclinical tCPR as well as the potentially preventable nature of the individual death cases...
November 15, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/29119070/superior-ophthalmic-vein-access-for-embolization-of-an-indirect-carotid-cavernous-fistula
#16
Ali S Haider, Prabhat Garg, Dean Leonard, Tijani Osumah, Umair Khan, Steven Vayalumkal, Lyndon K Lee, Phu Nguyen, Grant Gilliland, Kennith F Layton
Carotid cavernous fistulae (CCF) are defined as abnormal connections between the carotid circulation and cavernous sinus. CCFs can be categorized as being direct or indirect. Direct CCFs are usually associated with trauma, whereas indirect CCFs are associated with revascularization following cavernous sinus thrombosis. We present a case of a 53-year-old male who presented with tinnitus, proptosis, conjunctivitis, and blurry vision. The patient had a recent endovascular transvenous embolization that was only partially successful, with a residual carotid cavernous fistula draining to the left superior ophthalmic vein and multiple cortical veins...
September 1, 2017: Curēus
https://www.readbyqxmd.com/read/29102036/coronary-computed-tomographic-angiography-derived-fractional-flow-reserve-for-therapeutic-decision-making
#17
Christian Tesche, Rozemarijn Vliegenthart, Taylor M Duguay, Carlo N De Cecco, Moritz H Albrecht, Domenico De Santis, Marcel C Langenbach, Akos Varga-Szemes, Brian E Jacobs, David Jochheim, Moritz Baquet, Richard R Bayer, Sheldon E Litwin, Ellen Hoffmann, Daniel H Steinberg, U Joseph Schoepf
This study investigated the performance of coronary computed tomography angiography (cCTA) with cCTA-derived fractional flow reserve (CT-FFR) compared with invasive coronary angiography (ICA) with fractional flow reserve (FFR) for therapeutic decision making in patients with suspected coronary artery disease (CAD). Seventy-four patients (62 ± 11 years, 62% men) with at least 1 coronary stenosis of ≥50% on clinically indicated dual-source cCTA, who had subsequently undergone ICA with FFR measurement, were retrospectively evaluated...
September 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29096750/clinical-efficacy-and-mechanism-of-lymphoplasma-exchange-in-the-treatment-of-guillain-barre-syndrome
#18
M-C Luo, W-F Wang, W-F Yin, Y Li, B-J Li, W-W Duan, Q-M Zeng, Y-B Luo, X-S Yang, H Yang
Guillain-Barre syndrome (GBS) is an autoimmune disease of the nervous system and is the most common acute polyneuropathy. Both cellular and humoral immunity are believed to be involved in the pathogenesis of GBS, and various types of activated CD4+ T cells are thought to orchestrate the onset and progression of GBS. Lymphoplasma exchange (LPE) filtering out activated lymphocytes while exchanging plasma has been used for GBS treatment for years. However the treatment is still not yet optimal. In order to assess the efficacy of this treatment, we evaluate the effect of LPE and determine the appropriate frequency of LPE treatments for GBS patients through comparing the neurological deficit scores and the changes in related immunology indicators of GBS patients before and after LPE treatment...
October 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29088994/a-generic-simulation-model-of-the-relative-cost-effectiveness-of-icu-versus-step-down-imcu-expansion
#19
Amin Mahmoudian-Dehkordi, Somayeh Sadat
BACKGROUND: Many jurisdictions are facing increased demand for intensive care. There are two long-term investment options: intensive care unit (ICU) versus step-down or intermediate care unit (IMCU) capacity expansion. Relative cost-effectiveness of the two investment strategies with regard to patient lives saved has not been studied to date. METHODS: We expand a generic system dynamics simulation model of emergency patient flow in a typical hospital, populated with empirical evidence found in the medical and hospital administration literature, to estimate the long-term effects of expanding ICU versus IMCU beds on patient lives saved under a common assumption of 2...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29055662/organization-in-response-to-massive-afflux-of-war-victims-in-civilian-practice%C3%A2-%C3%A2-experimental-feedback-from-the-november-2015-paris-terrorist-attacks
#20
M Borel, R Rousseau, F Le Saché, D Pariente, S Castro, M Delay, P Hausfater, M Raux, F Menegaux
The arrival of a large number of war-weapon casualties at a civilian trauma center requires anticipation. A plan defining the management principles and the respective roles of the involved physicians and nurses and their interaction with each other is essential. Uni-directional patient flow associated with adequate numbers of staff physicians and nurses under the leadership of a medical director is essential to prevent the overwhelming of the trauma center. Routine and regular interaction between the pre-hospital medical flow control system and the medical director, on one hand, and between surgical teams and the medical director, on the other, are necessary to know when to apply "damage control" surgical techniques...
December 2017: Journal of Visceral Surgery
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