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Melatonin meta-analysis

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https://www.readbyqxmd.com/read/28272467/meta-analysis-identifies-novel-risk-loci-and-yields-systematic-insights-into-the-biology-of-male-pattern-baldness
#1
Stefanie Heilmann-Heimbach, Christine Herold, Lara M Hochfeld, Axel M Hillmer, Dale R Nyholt, Julian Hecker, Asif Javed, Elaine G Y Chew, Sonali Pechlivanis, Dmitriy Drichel, Xiu Ting Heng, Ricardo C-H Del Rosario, Heide L Fier, Ralf Paus, Rico Rueedi, Tessel E Galesloot, Susanne Moebus, Thomas Anhalt, Shyam Prabhakar, Rui Li, Stavroula Kanoni, George Papanikolaou, Zoltán Kutalik, Panos Deloukas, Michael P Philpott, Gérard Waeber, Tim D Spector, Peter Vollenweider, Lambertus A L M Kiemeney, George Dedoussis, J Brent Richards, Michael Nothnagel, Nicholas G Martin, Tim Becker, David A Hinds, Markus M Nöthen
Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (P<5 × 10(-8), METAL) of which 23 have not been reported previously. The 63 loci explain ∼39% of the phenotypic variance in MPB and highlight several plausible candidate genes (FGF5, IRF4, DKK2) and pathways (melatonin signalling, adipogenesis) that are likely to be implicated in the key-pathophysiological features of MPB and may represent promising targets for the development of novel therapeutic options...
March 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28258648/effectiveness-of-sleep-based-interventions-for-children-with-autism-spectrum-disorder-a-meta-synthesis
#2
Belinda M Cuomo, Sharmila Vaz, Elinda Ai Lim Lee, Craig Thompson, Jessica M Rogerson, Torbjorn Falkmer
Sleep problems are common in children with autism spectrum disorder (ASD). This meta-synthesis collated eight previously published systematic reviews examining the efficacy of sleep interventions in children with ASD in an attempt to present a clear analysis of trialed interventions. The collated reviews consider five major groups of sleep interventions for children with ASD: melatonin therapy, pharmacologic treatments other than melatonin, behavioral interventions, parent education/education programs, and alternative therapies (massage therapy, aromatherapy, and multivitamin and iron supplementation)...
March 4, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28065420/effectiveness-of-dietary-supplements-in-spinal-cord-injury-subjects
#3
REVIEW
Angela Navarrete-Opazo, Pilar Cuitiño, Inés Salas
BACKGROUND: Individuals with spinal cord injury (SCI) consume more dietary supplements than the general population. However, there is limited information regarding the clinical effectiveness of dietary supplements in SCI population. OBJECTIVE: To systematically review the effectiveness of dietary supplements for the prevention or treatment of health-related conditions associated with SCI. METHODS: Randomized or non-randomized controlled clinical trials were selected, comparing the effect of any dose and form of a dietary supplement (defined by the Dietary Supplement Health and Education Act), with either no treatment, placebo, or other medication...
December 19, 2016: Disability and Health Journal
https://www.readbyqxmd.com/read/27897121/role-of-melatonin-in-body-weight-a-systematic-review-and-meta-analysis
#4
Seyed-Ali Mostafavi, Shahin Akhondzadeh, Mohammad Reza Mohammadi, Abbas-Ali Keshtkar, Saeed Hosseini, Mohammad Reza Eshraghian, Fahimeh Ahmadi, Roya Alipour, Seyed Ali Keshavarz
BACKGROUND: Some trials on animals and human claim that melatonin can influence body weight. So we conducted a systematic review of controlled trials of melatonin effects on weight of human subjects. METHODS: First we performed a systematic and comprehensive search in June 2015 on MEDLINE/PubMed, Scopus, Google scholar, hand searching in key journals, the list of references of selected articles and gray literature. RESULTS: We included 7 clinical trials with a total of 244 patients...
November 29, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27851868/pharmacotherapies-for-sleep-disturbances-in-dementia
#5
REVIEW
Jenny McCleery, Daniel A Cohen, Ann L Sharpley
BACKGROUND: Sleep disturbances, including reduced nocturnal sleep time, sleep fragmentation, nocturnal wandering, and daytime sleepiness are common clinical problems in dementia, and are associated with significant caregiver distress, increased healthcare costs, and institutionalisation. Drug treatment is often sought to alleviate these problems, but there is significant uncertainty about the efficacy and adverse effects of the various hypnotic drugs in this vulnerable population. OBJECTIVES: To assess the effects, including common adverse effects, of any drug treatment versus placebo for sleep disorders in people with dementia, through identification and analysis of all relevant randomised controlled trials (RCTs)...
November 16, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27645169/meta-analysis-of-randomized-double-blind-placebo-controlled-trials-of-melatonin-in-alzheimer-s-disease
#6
REVIEW
Yuan-Yuan Wang, Wei Zheng, Chee H Ng, Gabor S Ungvari, Wei Wei, Yu-Tao Xiang
OBJECTIVE: This is a meta-analysis of randomized controlled trials (RCTs) of the efficacy of melatonin in Alzheimer's disease (AD). METHODS: Both English (PubMed, PsycINFO, Embase, Cochrane Library databases, and the Cochrane Controlled Trials Register) and Chinese (WanFang Database, Chinese Biomedical Database, and China Journal Net) databases were systematically and independently searched by two authors from their inception until 1 March 2016. Weighted and standard mean differences (SMDs), risk ratio (RR) ±95% confidence intervals (CIs) were calculated...
January 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27513702/melatonin-as-add-on-treatment-for-epilepsy
#7
REVIEW
Francesco Brigo, Stanley C Igwe, Alessandra Del Felice
BACKGROUND: This is an updated version of the original Cochrane review published in Issue 6, 2012.Epilepsy is one of the most common chronic neurological disorders. Despite the plethora of antiepileptic drugs (AEDs) currently available, 30% of people continue having seizures. This group of people requires a more aggressive treatment, since monotherapy, the first choice scheme, fails to control seizures. Nevertheless, polytherapy often results in a number of unwanted effects, including neurological disturbances (somnolence, ataxia, dizziness), psychiatric and behavioural symptoms, and metabolic alteration (osteoporosis, inducement or inhibition of hepatic enzymes, etc...
August 11, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27473952/pharmacological-interventions-to-improve-sleep-in-hospitalised-adults-a-systematic-review
#8
Salmaan Kanji, Alexandru Mera, Brian Hutton, Lisa Burry, Erin Rosenberg, Erika MacDonald, Vanessa Luks
OBJECTIVES: Patients often suffer from disturbed sleep in hospital. Poor-quality sleep in hospitalised patients has been associated with significant morbidity and pharmacological sleep aids are often prescribed. The objective of this systematic review is to evaluate the comparative efficacy and safety of pharmacological interventions used for sleep in hospitalised patients. SETTING/PARTICIPANTS: We searched MEDLINE, Embase, the Cochrane database and grey literature for prospective studies that evaluated sleep in hospitalised adults after a pharmacological intervention...
July 29, 2016: BMJ Open
https://www.readbyqxmd.com/read/27294772/the-role-of-melatonin-and-melatonin-agonists-in-counteracting-antipsychotic-induced-metabolic-side-effects-a-systematic-review
#9
Hee Ryung Wang, Young Sup Woo, Won-Myong Bahk
This systematic review aims to investigate whether melatonin or melatonin agonists significantly attenuate metabolic side effects among psychiatric populations treated with atypical antipsychotics. Four randomized-controlled trials were identified through a comprehensive literature search using MEDLINE, EMBASE, and the Cochrane Library on 22 October 2015. These four trials (including three melatonin studies and one ramelteon study) included 138 patients, of whom 71 were treated with melatonin or ramelteon and 67 were treated with a placebo...
November 2016: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/26997408/somatic-positive-and-negative-domains-of-the-center-for-epidemiological-studies-depression-ces-d-scale-a-meta-analysis-of-genome-wide-association-studies
#10
A Demirkan, J Lahti, N Direk, A Viktorin, K L Lunetta, A Terracciano, M A Nalls, T Tanaka, K Hek, M Fornage, J Wellmann, M C Cornelis, H M Ollila, L Yu, J A Smith, L C Pilling, A Isaacs, A Palotie, W V Zhuang, A Zonderman, J D Faul, A Sutin, O Meirelles, A Mulas, A Hofman, A Uitterlinden, F Rivadeneira, M Perola, W Zhao, V Salomaa, K Yaffe, A I Luik, Y Liu, J Ding, P Lichtenstein, M Landén, E Widen, D R Weir, D J Llewellyn, A Murray, S L R Kardia, J G Eriksson, K Koenen, P K E Magnusson, L Ferrucci, T H Mosley, F Cucca, B A Oostra, D A Bennett, T Paunio, K Berger, T B Harris, N L Pedersen, J M Murabito, H Tiemeier, C M van Duijn, K Räikkönen
BACKGROUND: Major depressive disorder (MDD) is moderately heritable, however genome-wide association studies (GWAS) for MDD, as well as for related continuous outcomes, have not shown consistent results. Attempts to elucidate the genetic basis of MDD may be hindered by heterogeneity in diagnosis. The Center for Epidemiological Studies Depression (CES-D) scale provides a widely used tool for measuring depressive symptoms clustered in four different domains which can be combined together into a total score but also can be analysed as separate symptom domains...
June 2016: Psychological Medicine
https://www.readbyqxmd.com/read/26986179/melatonin-as-add-on-treatment-for-epilepsy
#11
REVIEW
Francesco Brigo, Stanley C Igwe
BACKGROUND: This is an updated version of the original Cochrane review published in Issue 6, 2012.Epilepsy is one of the most common chronic neurological disorders. Despite the plethora of antiepileptic drugs (AEDs) currently available, 30% of people continue having seizures. This group of people requires a more aggressive treatment, since monotherapy, the first choice scheme, fails to control seizures. Nevertheless, polytherapy often results in a number of unwanted effects, including neurological disturbances (somnolence, ataxia, dizziness), psychiatric and behavioural symptoms, and metabolic alteration (osteoporosis, inducement or inhibition of hepatic enzymes, etc...
March 17, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26967259/interventions-for-preventing-delirium-in-hospitalised-non-icu-patients
#12
REVIEW
Najma Siddiqi, Jennifer K Harrison, Andrew Clegg, Elizabeth A Teale, John Young, James Taylor, Samantha A Simpkins
BACKGROUND: Delirium is a common mental disorder, which is distressing and has serious adverse outcomes in hospitalised patients. Prevention of delirium is desirable from the perspective of patients and carers, and healthcare providers. It is currently unclear, however, whether interventions for preventing delirium are effective. OBJECTIVES: To assess the effectiveness of interventions for preventing delirium in hospitalised non-Intensive Care Unit (ICU) patients...
March 11, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26560173/melatonin-and-agomelatine-for-preventing-seasonal-affective-disorder
#13
REVIEW
Angela Kaminski-Hartenthaler, Barbara Nussbaumer, Catherine A Forneris, Laura C Morgan, Bradley N Gaynes, Jeffrey H Sonis, Amy Greenblatt, Jörg Wipplinger, Linda J Lux, Dietmar Winkler, Megan G Van Noord, Julia Hofmann, Gerald Gartlehner
BACKGROUND: Seasonal affective disorder (SAD) is a seasonal pattern of recurrent major depressive episodes that most commonly occurs during autumn or winter and remits in spring. The prevalence of SAD in the United States ranges from 1.5% to 9%, depending on latitude. The predictable seasonal aspect of SAD provides a promising opportunity for prevention. This is one of four reviews on the efficacy and safety of interventions to prevent SAD; we focus on agomelatine and melatonin as preventive interventions...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26560172/psychological-therapies-for-preventing-seasonal-affective-disorder
#14
REVIEW
Catherine A Forneris, Barbara Nussbaumer, Angela Kaminski-Hartenthaler, Laura C Morgan, Bradley N Gaynes, Jeffrey H Sonis, Amy Greenblatt, Jörg Wipplinger, Linda J Lux, Dietmar Winkler, Megan G Van Noord, Julia Hofmann, Gerald Gartlehner
BACKGROUND: Seasonal affective disorder (SAD) is a seasonal pattern of recurrent major depressive episodes that most commonly occurs during autumn or winter and remits in spring. The prevalence of SAD ranges from 1.5% to 9%, depending on latitude. The predictable seasonal aspect of SAD provides a promising opportunity for prevention. This is one of four reviews on the efficacy and safety of interventions to prevent SAD; we focus on psychological therapies as preventive interventions. OBJECTIVES: To assess the efficacy and safety of psychological therapies (in comparison with no treatment, other types of psychological therapy, second-generation antidepressants (SGAs), light therapy, melatonin or agomelatine or lifestyle interventions) in preventing SAD and improving patient-centred outcomes among adults with a history of SAD...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26547856/the-effect-of-melatonin-on-benzodiazepine-discontinuation-and-sleep-quality-in-adults-attempting-to-discontinue-benzodiazepines-a-systematic-review-and-meta-analysis
#15
REVIEW
Angela Wright, Jacqueline Diebold, Jaskiran Otal, Carly Stoneman, Jonathan Wong, Christine Wallace, Mark Duffett
BACKGROUND: Abrupt discontinuation of benzodiazepines often results in side effects including anxiety and insomnia, which can be barriers to discontinuation among long-term users. Melatonin improves the onset, duration, and quality of sleep. By preventing insomnia in those attempting to discontinue benzodiazepines, melatonin may facilitate benzodiazepine discontinuation. OBJECTIVES: The primary objective was to determine the effect of melatonin compared with placebo on benzodiazepine discontinuation in adults attempting to discontinue benzodiazepines...
December 2015: Drugs & Aging
https://www.readbyqxmd.com/read/26301183/predictors-of-spine-deformity-progression-in-adolescent-idiopathic-scoliosis-a-systematic-review-with-meta-analysis
#16
Andriy Noshchenko, Lilian Hoffecker, Emily M Lindley, Evalina L Burger, Christopher Mj Cain, Vikas V Patel, Andrew P Bradford
AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis (AIS) in order to evaluate their efficacy and level of evidence. METHODS: HASH(0x4c7b2a0) SELECTION CRITERIA: (1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies; (2) participants: adolescents with AIS aged from 10 to 20 years; and (3) treatment: observation, bracing, and other...
August 18, 2015: World Journal of Orthopedics
https://www.readbyqxmd.com/read/26255301/exogenous-melatonin-for-sleep-disorders-in-neurodegenerative-diseases-a-meta-analysis-of-randomized-clinical-trials
#17
Wei Zhang, Xue-yan Chen, Su-wen Su, Qing-zhong Jia, Tao Ding, Zhong-ning Zhu, Tong Zhang
The purpose of this work is to investigate the efficacy of exogenous melatonin in the treatment of sleep disorders in patients with neurodegenerative disease. We searched Pubmed, the Cochrane Library, and ClinicalTrials.gov, from inception to July 2015. We included randomized clinical trials (RCTs) that compared melatonin with placebo and that had the primary aim of improving sleep in people with neurodegenerative diseases, particularly Alzheimer's disease (AD) and Parkinson's disease (PD). We pooled data with the weighted mean difference in sleep outcomes...
January 2016: Neurological Sciences
https://www.readbyqxmd.com/read/26241867/the-bipolarity-of-light-and-dark-a-review-on-bipolar-disorder-and-circadian-cycles
#18
REVIEW
T Abreu, M Bragança
BACKGROUND: Bipolar Disorder is characterized by episodes running the full mood spectrum, from mania to depression. Between mood episodes, residual symptoms remain, as sleep alterations, circadian cycle disturbances, emotional deregulation, cognitive impairment and increased risk for comorbidities. The present review intends to reflect about the most recent and relevant information concerning the biunivocal relation between bipolar disorder and circadian cycles. METHODS: It was conducted a literature search on PubMed database using the search terms "bipolar", "circadian", "melatonin", "cortisol", "body temperature", "Clock gene", "Bmal1 gene", "Per gene", "Cry gene", "GSK3β", "chronotype", "light therapy", "dark therapy", "sleep deprivation", "lithum" and "agomelatine"...
October 1, 2015: Journal of Affective Disorders
https://www.readbyqxmd.com/read/26225499/effects-of-melatonin-premedication-to-prevent-emergence-agitation-after-general-anaesthesia-in-children-a-systematic-review-and-meta-analysis-with-trial-sequential-analysis
#19
REVIEW
Takahiro Mihara, Nobuhito Nakamura, Koui Ka, Mari S Oba, Takahisa Goto
BACKGROUND: Emergence agitation is a common phenomenon in children recovering from general anaesthesia. An emergence agitation reaction increases the risk of injuring the surgical repair, the patient and the caregivers. OBJECTIVE: The objective of this study is to examine the efficacy of melatonin premedication in emergence agitation prevention. DESIGN: A systematic review and meta-analysis of randomised controlled trials (RCTs) with trial sequential analysis (TSA) and meta-regression analysis...
December 2015: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/26189834/exogenous-melatonin-for-delirium-prevention-a-meta-analysis-of-randomized-controlled-trials
#20
Sheng Chen, LiGen Shi, Feng Liang, Liang Xu, Doycheva Desislava, Qun Wu, Jianmin Zhang
Recently, two high-quality clinical randomized controlled trials (RCTs) regarding the preventive effect of exogenous melatonin on delirium drew inconsistent conclusions. We therefore performed a systemic review to explore whether melatonin had a benefit on delirium prevention. MEDLINE, EMBASE, and Cochrane Library were searched from January 1980 to April 2015 for English language studies. After strict selection and evaluation, the data were extracted from the included four RCTs. The primary outcome of this meta-analysis was the incidence of delirium...
August 2016: Molecular Neurobiology
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