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https://www.readbyqxmd.com/read/29049198/expression-analysis-of-e-cad-and-vascular-endothelial-growth-factor-in-triple-negative-breast-cancer-patients-of-different-ethnic-groups-in-western-china
#1
Weihua Jiang, Yongtao Li, Jianghua Ou, Xiaowen Wang, Chenguang Zhang, Lina Yi, Laiti Xue, Mingshuai Zhang
The aim of this article is to investigate the expression of E-cadherin (E-cad) and vascular endothelial growth factor (VEGF) in triple-negative breast cancer (TNBC) of Han and Uygur women patients in western China, and their relationship with clinical features of TNBC.Totally, 172 cases of Han TNBC patients and 79 cases of Uighur TNBC patients were enrolled. The expressions of E-cad and VEGF were detected with immunohistochemistry. The correlation of E-cad and VEGF expression with lymph node metastasis, TNM stage, and histological grade were analyzed...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048015/computer-aided-design-model-assisted-absolute-three-dimensional-shape-measurement
#2
Beiwen Li, Tyler Bell, Song Zhang
Conventional three-dimensional (3D) shape measurement methods are typically generic to all types of objects. Yet, for many measurement conditions, such a level of generality is inessential when having the preknowledge of the object geometry. This paper introduces a novel adaptive algorithm for absolute 3D shape measurement with the assistance of the object computer-aided-design (CAD) model. The proposed algorithm includes the following major steps: (1) export the 3D point cloud data from the CAD model; (2) transform the CAD model into the camera perspective; (3) obtain a wrapped phase map from three phase-shifted fringe images; and (4) retrieve absolute phase and 3D geometry assisted by the CAD model...
August 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047500/step-by-step-guide-to-reduce-spatial-coherence-of-laser-light-using-a-rotating-ground-glass-diffuser
#3
Tim Stangner, Hanqing Zhang, Tobias Dahlberg, Krister Wiklund, Magnus Andersson
Wide field-of-view imaging of fast processes in a microscope requires high light intensities motivating the use of lasers as light sources. However, due to their long spatial coherence length, lasers are inappropriate for such applications, as they produce coherent noise and parasitic reflections, such as speckle, degrading image quality. Therefore, we provide a step-by-step guide for constructing a speckle-free and high-contrast laser illumination setup using a rotating ground glass diffuser driven by a stepper motor...
July 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047385/fully-quantitative-cardiovascular-magnetic-resonance-myocardial-perfusion-ready-for-clinical-use-a-comparison-between-cardiovascular-magnetic-resonance-imaging-and-positron-emission-tomography
#4
Henrik Engblom, Hui Xue, Shahnaz Akil, Marcus Carlsson, Cecilia Hindorf, Jenny Oddstig, Fredrik Hedeer, Michael S Hansen, Anthony H Aletras, Peter Kellman, Håkan Arheden
BACKGROUND: Recent studies have shown that quantification of myocardial perfusion (MP) at stress and myocardial perfusion reserve (MPR) offer additional diagnostic and prognostic information compared to qualitative and semi-quantitative assessment of myocardial perfusion distribution in patients with coronary artery disease (CAD). Technical advancements have enabled fully automatic quantification of MP using cardiovascular magnetic resonance (CMR) to be performed in-line in a clinical workflow...
October 19, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29047356/non-syndromic-cardiac-progeria-in-a-patient-with-the-rare-pathogenic-p-asp300asn-variant-in-the-lmna-gene
#5
Ali J Marian
BACKGROUND: Mutations in LMNA gene, encoding Lamin A/C, cause a diverse array of phenotypes, collectively referred to as laminopathies. The most common manifestation is dilated cardiomyopathy (DCM), occurring in conjunction with variable skeletal muscle involvement but without involvement of the coronary arteries. Much less commonly, LMNA mutations cause progeroid syndromes, whereby an early-onset coronary artery disease (CAD) is the hallmark of the disease. We report a hitherto unreported compound cardiac phenotype, dubbed as "non-syndromic cardiac progeria", in a young patient who carried a rare pathogenic variant in the LMNA gene and developed progressive degeneration of various cardiac structures, as seen in the elderly...
October 18, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/29047198/evaluation-of-narrow-band-ultraviolet-b-phototherapy-in-the-treatment-of-chronic-actinic-dermatitis-in-chinese-patients
#6
Li Ma, Qiaoan Zhang, Yue Hu, Xiaoqun Luo
Few studies have been conducted in chronic actinic dermatitis (CAD) treated with narrowband ultraviolet B (NB UVB) phototherapy, especially in Asian patients. We aim to evaluate the efficacy and safety of NB UVB phototherapy in Chinese patients with CAD. 19 CAD patients of Fitzpatrick skin phototype IV received NB UVB phototherapy in spring and treatments were given 3 times weekly with incremental dose and maintenance therapy was given twice weekly for 3-4 weeks. The mean initial, endpoint, and cumulative dose of NB UVB was 0...
October 19, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/29046974/stress-echocardiography-in-stable-coronary-artery-disease
#7
REVIEW
Sothinathan Gurunathan, Roxy Senior
PURPOSE OF REVIEW: Stress echocardiography (SE) is a well-established technique for the diagnosis and risk stratification of patients with known or suspected coronary artery disease (CAD). This review article summarizes the status of SE in CAD, including testing protocols, clinical efficacy and current use of newer technologies: myocardial perfusion, strain imaging, three-dimensional echocardiography and adjunctive carotid ultrasonography. RECENT FINDINGS: Recent major findings in SE include the clinical value of myocardial perfusion imaging in multicentre studies, as well as when added to left ventricular (LV) wall motion assessment in clinical service...
October 18, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/29046758/coronary-artery-ectasia-presenting-with-acute-inferior-wall-myocardial-infarction-in-a-young-adult
#8
Htun Latt, Sammy Aung, Kyaw Kyaw, Richard Seher
Coronary artery ectasia (CAE), a variant of coronary artery anomalies, is a rare clinical entity. Although atherosclerotic coronary artery disease (CAD) is the most common cause of acute coronary syndrome (ACS), CAE also conveys a relatively high risk for potentially life-threatening cardiac events. We report a case of a 35-year-old male with two-vessel CAE, who presented with acute inferior wall ST election myocardial infarction (STEMI). After initiating medical therapy including bivalirudin, emergent percutaneous coronary intervention (PCI) with stenting of postero-lateral branch of right coronary artery (RCA) was performed...
October 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29046689/an-updated-protocol-for-high-throughput-plant-tissue-sectioning
#9
Jonathan A Atkinson, Darren M Wells
Quantification of the tissue and cellular structure of plant material is essential for the study of a variety of plant sciences applications. Currently, many methods for sectioning plant material are either low throughput or involve free-hand sectioning which requires a significant amount of practice. Here, we present an updated method to provide rapid and high-quality cross sections, primarily of root tissue but which can also be readily applied to other tissues such as leaves or stems. To increase the throughput of traditional agarose embedding and sectioning, custom designed 3D printed molds were utilized to embed 5-15 roots in a block for sectioning in a single cut...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29045612/fractional-flow-reserve-and-myocardial-perfusion-by-computed-tomography-a-guide-to-clinical-application
#10
Joanne D Schuijf, Brian S Ko, Marcelo F Di Carli, Jacqueline Hislop-Jambrich, Abdul-Rahman Ihdayhid, Sujith K Seneviratne, João A C Lima
The aim of this paper is to provide a guide to the clinical application of the functional computed tomography (CT) techniques fractional flow reserve (CT FFR) and myocardial perfusion (CTP) in patients presenting for the evaluation of coronary artery disease (CAD). Both techniques have recently been introduced to complement coronary CT angiography (CTA) with physiological information. Evidence supporting their diagnostic accuracy accumulates at a fast pace, and both techniques are moving from research tools to clinical applications for specific subgroups of patients...
October 17, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29045288/effects-of-anti-inflammatory-medications-in-patients-with-coronary-artery-disease-a-focus-on-losmapimod
#11
Bradley Tun, William H Frishman
Inflammation plays an integral role in atherogenesis and the pathogenesis of coronary artery disease (CAD). The question remains as to whether targeted inhibition of specific pathways of inflammation will have any clinical benefits in CAD. In this article we will review p38 mitogen-activated protein kinase (p38 MAPK), one of the key sensors of cellular stress that plays an important role in the inflammatory cascade. In addition, we will review losmapimod, a reversible competitive inhibitor of the α and β isoforms of p38 MAPK, and its efficacy when added to standard of care in patients hospitalized with myocardial infarction...
October 17, 2017: Cardiology in Review
https://www.readbyqxmd.com/read/29044828/fracture-resistance-of-monolithic-glass-ceramics-versus-bilayered-zirconia-based-restorations
#12
Tamer A Hamza, Rana M Sherif
PURPOSE: To compare the fracture resistance of monolithic reinforced glass-ceramic restorations with bilayer zirconia-based restorations. MATERIALS AND METHODS: Fifteen ceramic crowns were fabricated on epoxy dies duplicated from a stainless steel master die. They were divided into 3 equal groups (n = 5) according to the type of ceramic material used: group I, monolithic lithium disilicate (IPS e.max CAD), group V, monolithic zirconia-reinforced lithium silicate (Vita Suprinity), and group B (bilayered zirconia substructure with veneering ceramic)...
October 18, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29044723/the-effects-of-crown-venting-or-pre-cementing-of-cad-cam-constructed-all-ceramic-crowns-luted-on-ytz-implants-on-marginal-cement-excess
#13
Lucia K Zaugg, Isabella Zehnder, Nadja Rohr, Jens Fischer, Nicola U Zitzmann
OBJECTIVES: The purpose of this study was to analyze the cement excess produced when cementing CAD/CAM-fabricated lithium disilicate (L) or zirconium dioxide (Z) crowns using adhesive cement (A) or resin-modified glass ionomer cement (B). Three different cementation techniques were applied: palatal venting (PV), pre-cementation with custom analogs (CA), and conventional standard procedure (SP). MATERIALS AND METHODS: Seventy-two crowns (36 each material) were assigned to 12 experimental groups depending on the restoration material (L, Z), type of cement (A, B), and cementation technique (PV, CA, SP)...
October 17, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29042807/association-between-interleukin-6-6r-gene-polymorphisms-and-coronary-artery-disease-in-russian-population-influence-of-interleukin-6-6r-gene-polymorphisms-on-inflammatory-markers
#14
Vadim Mitrokhin, Alexey Nikitin, Olga Brovkina, Dmitry Khodyrev, Alexander Zotov, Nikita Vachrushev, Dmitry Dragunov, Andrey Shim, Mitko Mladenov, Andre Kamkin
This study determined the genotype effects of interleukin (IL)-6/IL-6R single nucleotide polymorphisms (SNPs) on circulating levels of different cytokines in healthy and coronary artery disease (CAD) patients with different allele frequencies. In the control patients, rs1800795 showed significant differences in IL-18 concentrations between CC and CG and CC and GG genotypes (P=0.003 and 0.004, respectively). Furthermore, circulatory IL-1β was significantly different between GC and GG genotypes from the same SNP (P=0...
2017: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29042790/evaluation-of-vitamin-d-levels-in-relation-to-coronary-ct-angiographic-findings-in-an-iranian-population
#15
Maryam Moradi, Ali Foroutanfar
BACKGROUND: Vitamin D deficiency, as a predisposing factor for coronary artery disease (CAD), is a subject of increasing interest. However, its role as a risk factor has not been proven. This study aimed to investigate the relationship between serum vitamin D levels and CAD. MATERIALS AND METHODS: Using a cross-sectional design, 180 patients who were candidates for coronary computed tomography angiography (CCTA) were selected. Serum levels of vitamin D were measured and compared with the results of CCTA (including calcium score, and presence and severity of coronary artery involvement due to atherosclerotic plaques)...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29042294/impaired-cardiac-autonomic-regulation-and-long-term-risk-of-atrial-fibrillation-in-patients-with-coronary-artery-disease
#16
Santeri Nortamo, Olavi Ukkola, Antti Kiviniemi, Mikko Tulppo, Heikki Huikuri, Juha Perkiömäki
BACKGROUND: The influence of autonomic cardiac regulation on long-term risk of new-onset atrial fibrillation (AF) in coronary artery disease (CAD) is not well established. OBJECTIVE: To evaluate the value of heart rate variability (HRV), a marker of cardiac autonomic regulation, in predicting new-onset AF in CAD. METHODS: The Innovation to Reduce Cardiovascular Complications of Diabetes at the Intersection (ARTEMIS) study population consisted of 1,946 patients with CAD...
October 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29042219/accurate-classification-of-diminutive-colorectal-polyps-using-computer-aided-analysis
#17
Peng-Jen Chen, Meng-Chiung Lin, Mei-Ju Lai, Jung-Chun Lin, Henry Horng-Shing Lu, Vincent S Tseng
BACKGROUND & AIMS: Narrow-band imaging (NBI) is an image-enhanced form of endoscopy used to observed microstructures and capillaries of the mucosal epithelium that allows for real-time prediction of histologic features of colorectal polyps. However, NBI expertise is required to differentiate hyperplastic from neoplastic polyps with high levels of accuracy. We developed and tested a system of computer-aided diagnosis with a deep neural network (DNN-CAD) to analyze narrow-band images of diminutive colorectal polyps...
October 14, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29042116/marginal-discrepancy-dimensions-of-single-unit-metal-crowns-fabricated-by-using-cad-cam-milled-acrylate-resin-polymer-blocks-or-a-conventional-waxing-technique
#18
David Lalande, Jeffrey A Hodd, John S Brousseau, Van Ramos, Daniel Dunham, Frederick Rueggeberg
STATEMENT OF PROBLEM: Because crowns with open margins are a well-known problem and can lead to complications, it is important to assess the accuracy of margins resulting from the use of a new technique. Currently, data regarding the marginal fit of computer-aided design and computer-aided manufacturing (CAD-CAM) technology to fabricate a complete gold crown (CGC) from a castable acrylate resin polymer block are lacking. PURPOSE: The purpose of this in vitro study was to compare marginal discrepancy widths of CGCs fabricated by using either conventional hand waxing or acrylate resin polymer blocks generated by using CAD-CAM technology...
October 14, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29041001/hmgb1-expression-level-in-circulating-platelets-is-not-significantly-associated-with-outcomes-in-symptomatic-coronary-artery-disease
#19
Dominik Rath, Tobias Geisler, Meinrad Gawaz, Sebastian Vogel
BACKGROUND/AIMS: Platelets express high-mobility group box 1 (HMGB1), a damage-associated molecular pattern molecule (DAMP) that triggers thrombosis and inflammation when present in extracellular space. The role of platelet-derived HMGB1 in coronary artery disease (CAD) remains unexplored. METHODS: In a cohort study, we measured the expression of HMGB1 on the surface of circulating platelets in 183 patients with symptomatic CAD (stable CAD: n=80, acute coronary syndrome, ACS: n=103) at the time of percutaneous coronary intervention...
October 17, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29039485/calcium-dobesilate-may-alleviate-diabetes%C3%A2-induced-endothelial-dysfunction-and-inflammation
#20
Yijun Zhou, Jiangzi Yuan, Chaojun Qi, Xinghua Shao, Shan Mou, Zhaohui Ni
Diabetic kidney disease (DKD) is a leading cause of end‑stage renal disease. However, the pathogenesis of DKD remains unclear, and no effective treatments for the disease are available. Thus, there is an urgent need to elucidate the pathogenic mechanisms of DKD and to develop more effective therapies for this disease. Human umbilical vein endothelial cells (HUVECs) were cultured using different D‑glucose concentrations to determine the effect of high glucose (HG) on the cells. Alternatively, HUVECs were incubated with 100 µmol/l calcium dobesilate (CaD) to detect its effects...
October 9, 2017: Molecular Medicine Reports
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