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Yi Liu, Sunjuan Zhang, Feng Ye, Jieyun Yin, Shiying Li, Jiande D Z Chen
BACKGROUND: Chemotherapy-associated dyspepsia syndrome (CADS) is among the most intensive side effects and critical concerns for patients with cancer. To investigate the effects and mechanisms of chronic electroacupuncture (EA) at ST36 on chemotherapy-associated dyspeptic symptoms (CADS) in rats. METHODS: Cisplatin (8 mg/kg, ip) was given once to establish CADS model. EA or sham-EA treatment was then performed one hour daily for 21 days. KEY RESULTS: (a) EA treatment decreased kaolin intake within 24 hours (1...
September 23, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Ruei-Je Tsai, Hsin-Yi Lai, Cheng-Fu Ni, Shu-Min Tsao, Gong-Yau Lan, Kevin Li-Chun Hsieh
PURPOSE AND BACKGROUND: Cardiovascular disease (CVD) is one of the leading causes of death. However, the prevalence of CVD in young adults (<40 years of age) has not been well documented. We conducted this study to determine the proportion of CVD in both symptomatic and asymptomatic young adults. MATERIALS AND METHODS: Coronary CT angiography images obtained from April 2015 to July 2017 in our institution was retrospectively reviewed. Young adults were separated into two groups according to whether they had experienced chest discomfort...
September 20, 2018: Clinical Imaging
Klaus Schilling, Ruben Pawellek, Katherine Lovejoy, Tibor Muellner, Ulrike Holzgrabe
The analysis of polysorbate 80 is a challenge because all components lack a chromophore. Here, an ultra-high-performance liquid chromatography system equipped with a charged aerosol detector (UHPLC-CAD) was used to study the effect of systematic variation of the CAD settings, namely evaporation temperature, filter constant and power function value (PFV), on the detector response of fatty acid standards and manufacturing batches of polysorbate. Evaporation temperature and filter constant strongly affect the detection limits described by signal-to-noise (S/N) ratios...
September 18, 2018: Journal of Chromatography. A
Sebastian Bohnen, Maxim Avanesov, Annika Jagodzinski, Renate B Schnabel, Tanja Zeller, Mahir Karakas, Jan Schneider, Enver Tahir, Ersin Cavus, Clemens Spink, Ulf K Radunski, Francisco Ojeda, Gerhard Adam, Stefan Blankenberg, Gunnar K Lund, Kai Muellerleile
BACKGROUND: The purpose of this work is to describe the objectives and design of cardiovascular magnetic resonance (CMR) imaging in the single center, prospective, population-based Hamburg City Health study (HCHS). The HCHS aims at improving risk stratification for coronary artery disease (CAD), atrial fibrillation (AF) and heart failure (HF). METHODS: The HCHS will finally include 45,000 inhabitants of the city of Hamburg (Germany) between 45 and 74 years who undergo an extensive cardiovascular evaluation and collection of biomaterials...
September 24, 2018: Journal of Cardiovascular Magnetic Resonance
Salvatore Gitto, Giorgia Grassi, Chiara De Angelis, Cristian Giuseppe Monaco, Silvana Sdao, Francesco Sardanelli, Luca Maria Sconfienza, Giovanni Mauri
AIM OF THE STUDY: To compare the diagnostic performance of a commercially available computer-aided diagnosis (CAD) system for thyroid ultrasound (US) with that of a non-computer-aided radiologist in the characterization of low-to-high suspicion thyroid nodules. METHODS: This retrospective study included a consecutive series of adult patients referred for US-guided fine-needle aspiration biopsy (FNAB) of a thyroid nodule. All patients were eligible for thyroid nodule FNAB according to the current international guidelines...
September 22, 2018: La Radiologia Medica
W Du, G Chen, D Bai, C Xue, W Fei, E Luo
Severe skeletal open bite associated with posterior vertical maxillary excess and mandibular deformity is considered a difficult problem in orthodontic and surgical treatment. This study used a navigation system for the correction of severe skeletal open bite in order to accurately transfer the virtual plan to the actual operation and achieve precise rigid internal fixation in bimaxillary osteotomies of the jaws. Twelve patients with a severe skeletal open bite associated with vertical maxillary excess and mandibular deformity were recruited...
September 19, 2018: International Journal of Oral and Maxillofacial Surgery
Hsin-Bang Leu, Wei-Hsian Yin, Wei-Kung Tseng, Yen-Wen Wu, Tsung-Hsien Lin, Hung-I Yeh, Kuan- Cheng Chang, Ji-Hung Wang, Chau-Chung Wu, Jaw-Wen Chen
BACKGROUND: Some personality types are associated with cardiovascular (CV) diseases and may be related to clinical outcomes in coronary artery disease (CAD). This study investigates the association between type D personality and clinical outcomes in stable CAD patients in an Asian cohort. METHODS: Stable CAD patients were enrolled and prospectively followed up for at least 1 year in Taiwan. The inclusion criteria were at least one successful percutaneous coronary intervention (PCI) and stable medical treatment for at least 1 month before enrollment...
September 19, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Vincent I O Agyapong, Michal Juhás, Kelly Mrklas, Marianne Hrabok, Joy Omeje, Irene Gladue, Jody Kozak, Maureen Leslie, Pierre Chue, Andrew J Greenshaw
AIMS: To evaluate the effectiveness of an addiction-related supportive text messaging mobile intervention to improve treatment outcomes for patients with alcohol use disorder (AUD). METHODS: A single-rater-blinded randomized trial was conducted involving 59 AUD patients who completed a residential addiction treatment program. Patients in the intervention group (n = 29) received supportive text messages for three months following discharge. Patients in the control group (n = 30) received a text message thanking them for participating in the study...
November 2018: Journal of Substance Abuse Treatment
Jae Hyun Lee, Joon Seon Yang, Sang-Hak Lee, Myeong Hee Moon
A comprehensive lipid analysis was performed at the plasma lipoprotein level in patients with acute coronary syndrome (ACS) and stable coronary artery disease (CAD). Because the lipids in lipoproteins are related to the pathology of the cardiovascular system, lipoprotein-specific lipid analysis can be useful for understanding the mechanism of lipid-associated cardiovascular diseases. Lipoproteins were size-sorted into high density lipoproteins (HDL) and low density lipoproteins (LDL) using asymmetrical flow field-flow fractionation, then lipids of each lipoprotein were analysed using nanoflow ultrahigh performance liquid chromatography-electrospray ionization-tandem mass spectrometry...
September 14, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Mahmoud Mohammadzadeh Shabestari, Leila Alizadeh, Mohammad Moshiri, Emadodin Darchini-Maragheh, Mahdi Balali-Mood
It was aimed to investigate possible late cardiac effects of Sulfur mustard (SM) exposure in Iranian veterans. Thirty-eight veterans with late complications of SM exposure were investigated. Clinical history, physical examinations, 12 leads electrocardiography and transthoracic echocardiography were performed. Computed tomography coronary angiography (CTCA) was performed as clinically indicated for angiographic assessment and patients were stratified according to the CTCA findings. Incomplete right bundle branch block and right axis deviation were detected in 3 (7...
September 21, 2018: Cardiovascular Toxicology
Rasha K Al-Lamee, Alexandra N Nowbar, Darrel P Francis
The adverse consequences of stable coronary artery disease (CAD) are death, myocardial infarction (MI) and angina. Trials in stable CAD show that percutaneous coronary intervention (PCI) does not reduce mortality. PCI does appear to reduce spontaneous MI rates but at the expense of causing some periprocedural MI. Therefore, the main purpose of PCI is to relieve angina. Indeed, patients and physicians often choose PCI rather than first attempting to control symptoms with anti-anginal medications as recommended by guidelines...
September 21, 2018: Heart: Official Journal of the British Cardiac Society
Huimin Li, Qian Tong, Lirong Guo, Shui Yu, Yuewei Li, Qinqin Cao, Jinwei Li, Feng Li
BACKGROUND: The association between chronic inflammation and the accelerated development of atherosclerosis is well recognized. However, it remains controversial as to whether the risk of coronary artery disease (CAD) is elevated in patients with systemic lupus erythematosus (SLE). The objective of this meta-analysis was to obtain a better estimate of the risk of CAD in patients with SLE. METHODS: An English-restricted literature review was conducted according to PRISMA guidelines using key databases, surveying all articles published through October 31, 2017...
August 8, 2018: American Journal of the Medical Sciences
Miriam S Udler, Jaegil Kim, Marcin von Grotthuss, Sílvia Bonàs-Guarch, Joanne B Cole, Joshua Chiou, Michael Boehnke, Markku Laakso, Gil Atzmon, Benjamin Glaser, Josep M Mercader, Kyle Gaulton, Jason Flannick, Gad Getz, Jose C Florez
BACKGROUND: Type 2 diabetes (T2D) is a heterogeneous disease for which (1) disease-causing pathways are incompletely understood and (2) subclassification may improve patient management. Unlike other biomarkers, germline genetic markers do not change with disease progression or treatment. In this paper, we test whether a germline genetic approach informed by physiology can be used to deconstruct T2D heterogeneity. First, we aimed to categorize genetic loci into groups representing likely disease mechanistic pathways...
September 2018: PLoS Medicine
Jiali Cai, Dongming Xu, Shiyuan Liu, Matthew D Cham
Lung cancer at its earliest stage is typically manifested on computed tomography as a pulmonary nodule, which could be detected by low-dose multidetector computed tomography technology and the use of thinner collimation. Within the last 2 decades, computer-aided detection (CAD) of pulmonary nodules has been developed to meet the increasing demand for lung cancer screening computed tomography with a larger set of images per scan. This review introduced the basic techniques and then summarized the up-to-date applications of CAD systems in clinical and research programs and in the low-dose lung cancer screening trials, especially in the detection of small pulmonary nodules and missed lung cancers...
September 19, 2018: Journal of Thoracic Imaging
Qiuju Miao, Huanwen Ding, Hong Wang, Qiang Tu, Jiarong Chen, Huiliang Liu
Objective: To evaluate the effectiveness of precise orthormorphia of tibial angulation deformity and shortening deformity by using digital technology combined with external fixator. Methods: Twenty-six cases of tibial angulation deformity combined with shortening deformity were treated between June 2012 and August 2016, including 12 males and 14 females aged from 1 to 19 years with an average age of 16.5 years. There were 6 cases of congenital patella pseudoarthrosis, 1 case of fibrous dysplasia of femur and tibia, 3 cases of limb shortening deformity caused by infantile paralysis, 16 cases of fracture malunion...
August 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Sung Eun Song, Kyu Ran Cho, Bo Kyoung Seo, Ok Hee Woo, Kyong Hwa Park, Yo Han Son, Robert Grimm
BACKGROUND: As both intravoxel incoherent motion (IVIM) modeling and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provide perfusion parameters, IVIM-derived perfusion parameters might be expected to correlate with the kinetic features from DCE-MRI. PURPOSE: To investigate the association between IVIM parameters and prognostic factors and to evaluate the correlation between IVIM parameters and kinetic features in invasive breast cancer patients using computer-aided diagnosis (CAD)...
September 20, 2018: Journal of Magnetic Resonance Imaging: JMRI
Roberto Sciagrà, Elisa Milan, Raffaele Giubbini, Tomasz Kubik, Rossella Di Dato, Lara Gallo, Luca Camoni, Michela Allocca, Raffaella Calabretta
BACKGROUND: This study examined whether measuring myocardial blood flow (MBF) in the sub-endocardial (SEN) and sub-epicardial (SEP) layers of the left ventricular myocardium using 13 NH3 positron emission tomography (PET) and an automated procedure gives reasonable results in patients with known or suspected coronary artery disease (CAD). METHODS: Resting and stress 13 NH3 dynamic PET were performed in 70 patients. Using ≥ 70% diameter stenosis in invasive coronary angiography (ICA) to identify significant CAD, we examined the diagnostic value of SEN- and SEP-MBF, and coronary flow reserve (CFR) vs...
September 20, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Shichiro Abe, Hiroyuki Sugimura, Shintaro Watanabe, Yoshiaki Murakami, Katsuhito Ebisawa, Tatsuya Ioka, Toshiyuki Takahashi, Toshiaki Ando, Kaori Kono, Teruo Inoue
Eicosapentaenoic acid (EPA) administration has been reported to decrease the incidence of cardiovascular events, and the serum EPA/arachidonic acid (AA) ratio has been identified as a potential new risk marker for coronary artery disease (CAD). The present study aimed to investigate the value of EPA treatment based on the EPA/AA ratio at baseline. We retrospectively analyzed clinical outcome data from 149 CAD patients with a baseline EPA/AA ratio ≤ 0.4 who had received purified EPA (EPA group) or not (no EPA group) and CAD patients with an EPA/AA ratio > 0...
September 20, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Fabio Mangiacapra, Mariano Pellicano, Luigi Di Serafino, Edoardo Bressi, Aaron J Peace, Giuseppe Di Gioia, Carmine Morisco, Jozef Bartunek, William Wijns, Bernard De Bruyne, Emanuele Barbato
BACKGROUND AND AIMS: Increased platelet reactivity (PR) associated with variable degree of coronary microvascular impairment has been reported in patients on clopidogrel after elective percutaneous coronary intervention (PCI). Prasugrel provides more potent platelet inhibition than clopidogrel, though it is unknown whether it might also prevent PCI-related platelet activation. In stable patients undergoing elective PCI, we compared: (1) the effects of prasugrel vs. clopidogrel on peri-procedural variations of PR and (2) the correlation of platelet inhibition potency with PCI-induced coronary microvascular impairment...
August 30, 2018: Atherosclerosis
Joel Aissa, Benedikt Michael Schaarschmidt, Janina Below, Oliver Th Bethge, Judith Böven, Lino Morris Sawicki, Norman-Philipp Hoff, Patric Kröpil, Gerald Antoch, Johannes Boos
PURPOSE: To evaluate performance and the clinical impact of a novel machine learning based vessel-suppressing computer-aided detection (CAD) software in chest computed tomography (CT) of patients with malignant melanoma. MATERIALS AND METHODS: We retrospectively included consecutive malignant melanoma patients with a chest CT between 01/2015 and 01/2016. Machine learning based CAD software was used to reconstruct additional vessel-suppressed axial images. Three radiologists independently reviewed a maximum of 15 lung nodules per patient...
September 11, 2018: Clinical Imaging
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