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https://www.readbyqxmd.com/read/29243273/long-term-use-of-continuous-positive-airway-pressure-therapy-in-coronary-artery-disease-patients-with-nonsleepy-obstructive-sleep-apnea
#1
Faith S Luyster, Patrick J Strollo, Erik Thunström, Yüksel Peker
BACKGROUND: Excessive daytime sleepiness is a frequent symptom of obstructive sleep apnea (OSA) and has been proposed as a motivator for adherence to continuous positive airway pressure (CPAP) therapy. However, excessive daytime sleepiness is absent in many patients with coronary artery disease (CAD) and concomitant OSA. We evaluated long-term use of CPAP and predictors of CPAP use in nonsleepy and sleepy OSA patients from a CAD cohort. HYPOTHESIS: Long-term CPAP use is lower in CAD patients with nonsleepy OSA vs sleepy OSA...
December 14, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29242847/simvastatin-intolerance-genetic-determinants-some-features-in-ethnic-uzbek-patients-with-coronary-artery-disease
#2
Aleksandr B Shek, Ravshanbek D Kurbanov, Guzal J Abdullaeva, Aleksandr V Nagay, Shavkat U Hoshimov, Ulugbek I Nizamov, Adolat V Ziyaeva, Rano B Alieva
Introduction: The objective is to study the influence of CYP3A5 (6986A>G), CYP2C9 (430C>T), CYP2C9 (1075A>C), SLCO1B1 (521T>C) and BCRP (ABCG2, 421C>A) gene polymorphisms on the development of simvastatin intolerance in ethnic Uzbek patients with coronary artery disease (CAD). Material and methods: The case group contained 50 patients with clinical simvastatin-induced intolerance symptoms; the control group contained 50 patients without side-effects...
2017: Archives of Medical Sciences. Atherosclerotic Diseases
https://www.readbyqxmd.com/read/29241944/fracture-resistance-and-failure-modes-of-polymer-infiltrated-ceramic-endocrown-restorations-with-variations-in-margin-design-and-occlusal-thickness
#3
Doaa Taha, Sebastian Spintzyk, Christine Schille, Ahmed Sabet, Marwa Wahsh, Tarek Salah, Jürgen Geis-Gerstorfer
PURPOSE: The purpose of this in vitro study was to assess the effect of varying the margin designs and the occlusal thicknesses on the fracture resistance and mode of failures of endodontically treated teeth restored with polymer infiltrated ceramic endocrown restorations. METHODS: Root canal treated mandibular molars were divided into four groups (n=8) and were prepared to receive Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) fabricated polymer infiltrated ceramic endocrowns (ENAMIC blocks)...
December 11, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/29241487/surgical-versus-percutaneous-coronary-revascularization-in-patients-with-diabetes-and-acute%C3%A2-coronary-syndromes
#4
Krishnan Ramanathan, James G Abel, Julie E Park, Anthony Fung, Verghese Mathew, Carolyn M Taylor, G B John Mancini, Min Gao, Lillian Ding, Subodh Verma, Karin H Humphries, Michael E Farkouh
BACKGROUND: Randomized trial data support the superiority of coronary artery bypass grafting (CABG) surgery over percutaneous coronary intervention (PCI) in diabetic patients with multivessel coronary artery disease (MV-CAD). However, whether this benefit is seen in a real-world population among subjects with stable ischemic heart disease (SIHD) and acute coronary syndromes (ACS) is unknown. OBJECTIVES: The main objective of this study was to assess the generalizability of the FREEDOM (Future REvascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multi-vessel Disease) trial in real-world practice among patients with diabetes mellitus and MV-CAD in residents of British Columbia, Canada...
December 19, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29240566/a-practical-clinical-approach-to-utilize-cardiopulmonary-exercise-testing-in-the-evaluation-and-management-of-coronary-artery-disease-a-primer-for-cardiologists
#5
Sundeep Chaudhry, Ross Arena, Deepak L Bhatt, Subodh Verma, Naresh Kumar
PURPOSE OF REVIEW: There is growing clinical interest for the use of cardiopulmonary exercise testing (CPET) to evaluate patients with or suspected coronary artery disease (CAD). With mounting evidence, this concise review with relevant teaching cases helps to illustrate how to integrate CPET data into real world patient care. RECENT FINDINGS: CPET provides a novel and purely physiological basis to identify cardiac dysfunction in symptomatic patients with both obstructive-CAD and nonobstructive-CAD (NO-CAD)...
December 13, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29240243/fabrication-and-evaluation-of-3d-printed-bcp-scaffolds-reinforced-with-zro2-for-bone-tissue-applications
#6
Min-Woo Sa, Bao-Ngoc B Nguyen, Rebecca A Moriarty, Timur Kamalitdinov, John P Fisher, Jong Young Kim
Fused deposition modeling (FDM) is a promising 3D printing and manufacturing step to create well interconnected porous scaffold designs from the computer-aided design (CAD) models for the next generation of bone scaffolds. The purpose of this study was to fabricate and evaluate a new biphasic calcium phosphate (BCP) scaffold reinforced with zirconia (ZrO2 ) by a FDM system for bone tissue engineering. The 3D slurry foams with blending agents were successfully fabricated by a FDM system. Blending materials were then removed after the sintering process at high temperature to obtain a targeted BCP/ZrO2 scaffold with the desired pore characteristics, porosity, and dimension...
December 14, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29239459/ischemic-left-ventricle-systolic-dysfunction-an-evidence-based-approach-in-diagnostic-tools-and-therapeutics
#7
Eduardo Gomes Lima, Felipe Pereira Câmara de Carvalho, Jaime Paula Pessoa Linhares Filho, Fabio Grunspun Pitta, Carlos Vicente Serrano
Coronary artery disease (CAD) associated with left ventricular systolic dysfunction is a condition related to poor prognosis. There is a lack of robust evidence in many aspects related to this condition, from definition to treatment. Ischemic cardiomyopathy is a spectrum ranging from stunned myocardium associated with myocardial fibrosis to hibernating myocardium and repetitive episodes of ischemia. In clinical practice, relevance lies in identifying the myocardium that has the ability to recover its contractile reserve after revascularization...
September 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29238826/a-re-engineered-software-interface-and-workflow-for-the-open-source-simvascular-cardiovascular-modeling-package
#8
Hongzhi Lan, Adam Updegrove, Nathan Wilson, Gabriel D Maher, Shawn C Shadden, Alison Marsden
Patient-specific simulation plays an important role in cardiovascular disease research, diagnosis, surgical planning and medical device design, as well as education in cardiovascular biomechanics. SimVascular is an open-source software package encompassing an entire cardiovascular modeling and simulation pipeline from image segmentation, 3D solid modeling, and mesh generation, to patient-specific simulation and analysis. SimVascular is widely used for cardiovascular basic science and clinical research as well as education, following increased adoption by users and development of a GATEWAY web portal to facilitate educational access...
December 13, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29238488/effect-of-hydrofluoric-acid-surface-treatments-on-micro-shear-bond-strength-of-cad-cam-ceramics
#9
Faraneh Mokhtarpour, Homayoon Alaghehmand, Soraya Khafri
Introduction: Dental ceramics are appreciated as highly esthetic restorative materials that can simulate the appearance of natural dentition better than other materials. The aim of this study was to evaluate the effect of hydrofluoric acid concentration and etching time on micro-shear bond strength (μSBS) to IPS e.max CAD and Vita Mark II of a dual cured resin cement (Panavia F2.0). Methods: This study was an experimental in vitro study, performed in the dental material research center of Babol University of Medical Sciences in 2016...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29238483/the-influence-of-polishing-techniques-on-pre-polymerized-cad-cam-acrylic-resin-denture-bases
#10
Manal Rahma Alammari
Background: Lately, computer-aided design and computer-aided manufacturing (CAD/CAM) has broadly been successfully employed in dentistry. The CAD/CAM systems have recently become commercially available for fabrication of complete dentures, and are considered as an alternative technique to conventionally processed acrylic resin bases. However, they have not yet been fully investigated. Objective: The purpose of this study was to inspect the effects of mechanical polishing and chemical polishing on the surface roughness (Ra) and contact angle (wettability) of heat-cured, auto-cured and CAD/CAM denture base acrylic resins...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29237301/response-to-letter-to-the-editor-entitled-correct-microarray-analysis-approaches-in-hsa-circrna11783-2-in-peripheral-blood-is-correlated-with-coronary-artery-disease-and-type-2-diabetes-mellitus
#11
Zhenzhou Zhao, Xuejie Li, Muwei Li
In the paper entailed 'Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus', we illustrated the correlation of circRNA with T2DM and CAD. We used the common method - Q-PCR to select differentially expressed circular RNA (differentially expressedgenes(DEGs)), with a criteria of fold change>2 and unadjusted p values < 0.05 in expression. When the candidate RNAs have been narrowed down by GO and Pathway analysis, Q-PCR is a good verification method, although the idea that using Q-PCR to verify all the DEGs is still unrealistic...
December 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29237072/appropriate-choice-of-stress-modality-in-patients-undergoing-myocardial-perfusion-scintigraphy-with-a-cardiac-camera-equipped-with-solid-state-detectors-the-role-of-diabetes-mellitus
#12
Alessia Gimelli, Riccardo Liga, Alberto Clemente, Emilio Maria Pasanisi, Brunella Favilli, Paolo Marzullo
Aims: To evaluate the impact of diabetes mellitus (DM) on the accuracy of myocardial perfusion scintigraphy (MPS) in detecting coronary artery disease (CAD). Methods and results: Two hundred and sixteen patients with DM and 432 matched controls were submitted to MPS on a dedicated cardiac camera equipped with cadmium-zinc-telluride (CZT) detectors and coronary angiography. Exercise stress was performed in 442 (68%) patients, while the remainders underwent vasodilator stress...
December 11, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29236974/diabetes-as-an-independent-predictor-of-left-ventricular-longitudinal-strain-reduction-at-rest-and-during-dobutamine-stress-test-in-patients-with-significant-coronary-artery-disease
#13
Karina Wierzbowska-Drabik, Ewa Trzos, Malgorzata Kurpesa, Tomasz Rechcinski, Dawid Miskowiec, Urszula Cieslik-Guerra, Barbara Uznanska-Loch, Maria Sobczak, Jaroslaw Damian Kasprzak
Aims: Diabetes (DM) is a strong cardiovascular risk factor modifying also the left ventricular (LV) function that may be objectively assessed with echocardiographic strain analysis. Although the impact of isolated DM on myocardial deformation has been already studied, few data concern diabetics with coronary artery disease (CAD), especially in all stages of dobutamine stress echocardiography (DSE). We compared LV systolic function during DSE in CAD with and without DM using state-of-the art speckle-tracking quantification and assessed the impact of DM on LV systolic strain...
December 9, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29236968/use-of-ultrasound-for-the-palpable-undescended-testis-a-wasteful-practice
#14
Carolyn Wayne, Luis A Guerra, Jiefei Yao, Mélise A Keays, Michael P Leonard
Background: Many primary care physicians order an ultrasound (US) before referral to specialist care for suspected undescended testis; however, the value of this practice is questionable. Objective: To determine the proportion of boys referred for suspected undescended testis who had accompanying US, the cost of this practice and the accuracy of US for testis localization when compared with physical examination by a pediatric urologist. Methods: This was a retrospective chart review at a pediatric urology service, including all patients referred for suspected undescended testis from 2008 to 2012...
December 10, 2017: Family Practice
https://www.readbyqxmd.com/read/29236951/epicardial-adipose-tissue-volume-assessed-by-computed-tomography-and-coronary-artery-disease-a-systematic-review-and-meta-analysis
#15
Jennifer Mancio, Diana Azevedo, Francisca Saraiva, Ana Isabel Azevedo, Gustavo Pires-Morais, Adelino Leite-Moreira, Ines Falcao-Pires, Nuno Lunet, Nuno Bettencourt
To conduct a systematic review and meta-analysis on the crude and adjusted associations between epicardial adipose tissue (EAT) volume determined by computed tomography (CT) and coronary artery disease (CAD). MEDLINE, Scopus, and Web of Science databases were screened for all observational studies assessing the association between EAT volume and CAD. We calculated pooled odds ratio (OR) or hazard ratio (HR) and 95% confidence intervals (CI) for the association per 10 cm3 variation of EAT by five different definitions of CAD: obstructive or significant coronary stenosis (luminal narrowing ≥50% and ≥70%, respectively), presence of coronary artery calcification (CAC), myocardial ischaemia, and major adverse cardiovascular events (MACE) using DerSimonian and Laird random-effects models...
December 9, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29236148/dual-antiplatelet-therapy-after-percutaneous-coronary-intervention-for-stable-cad-or-acs-redefining-the-optimal-duration-of%C3%A2-treatment
#16
B E Stähli, U Landmesser
The duration and combination of dual antiplatelet therapy after coronary stent implantation, consisting of aspirin and a P2Y12 inhibitor, is among the most intensely investigated therapeutic strategies in cardiovascular medicine. While initial studies have mainly focused on the efficacy and safety of individual antithrombotic agents, the increased need for a personalized, risk-based approach to define the optimal duration of antithrombotic treatment according to the estimated ischemic and bleeding risk was then recognized...
December 13, 2017: Herz
https://www.readbyqxmd.com/read/29235502/stress-induced-release-of-the-s100a8-a9-alarmin-is-elevated-in-coronary-artery-disease-patients-with-impaired-cortisol-response
#17
L Jonasson, H Grauen Larsen, A K Lundberg, B Gullstrand, A A Bengtsson, A Schiopu
Psychological stress is thought to be an important trigger of cardiovascular events, yet the involved pathways and mediators are largely unknown. Elevated systemic levels of the pro-inflammatory alarmin S100A8/A9 correlate with poor prognosis in coronary artery disease (CAD) patients. Here, we investigated the links between S100A8/A9 release and parameters of anti-inflammatory glucocorticoid secretion in two different cohorts subjected to a psychological stress test. In the first cohort of 60 CAD patients, psychological stress induced a rapid increase of circulating S100A8/A9...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235202/three-dimensional-static-articulation-accuracy-of-virtual-models-part-i-system-trueness-and-precision
#18
Sophia Hui Xin Yee, Roxanna Jean Esguerra, Amelia Anya Qin'An Chew, Keng Mun Wong, Keson Beng Choon Tan
PURPOSE: To evaluate the 3D static articulation accuracy of 3 model scanner-CAD systems (Ceramill Map400 [AG], inEos X5 [SIR], Scanner S600 Arti [ZKN]) using a coordinate measuring machine (CMM). Trueness and precision for each system will be reported in Part I. MATERIALS AND METHODS: The master model simulated a single crown opposing a 3-unit fixed dental prosthesis. Five mounted stone cast sets were prepared, and one set was randomly selected. Reference values were obtained by measuring interarch and interocclusal reference features with the CMM...
December 13, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29234038/sodium-tanshinone-iia-sulfate-adjunct-therapy-reduces-high-sensitivity-c-reactive-protein-level-in-coronary-artery-disease-patients-a-randomized-controlled-trial
#19
Siming Li, Yang Jiao, Hanjay Wang, Qinghua Shang, Fang Lu, Li Huang, Jiangang Liu, Hao Xu, Keji Chen
High-sensitivity C-reactive protein (hs-CRP) is independently associated with cardiovascular events in coronary artery disease (CAD) patients and reducing the hs-CRP level may further benefit this population. We conduct this parallel design, randomized-controlled trial to assess the effectiveness of adjunct sodium tanshinone IIA sulfate (STS) therapy on circulating inflammation markers in CAD patients. Unstable angina or non-ST-elevation myocardial infarction patients with increased hs-CRP level were randomly assigned to atorvastatin-based standard medical therapy or standard therapy plus STS injection (80 mg, once daily for 14 consecutive days)...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233683/caspase-mediated-cleavage-of-x-ray-repair-cross-complementing-group-4-promotes-apoptosis-by-enhancing-nuclear-translocation-of-caspase-activated-dnase
#20
Yumi Sunatani, Radhika Pankaj Kamdar, Mukesh Kumar Sharma, Tadashi Matsui, Ryo Sakasai, Mitsumasa Hashimoto, Yasuhito Ishigaki, Yoshihisa Matsumoto, Kuniyoshi Iwabuchi
X-ray repair cross-complementing group 4 (XRCC4), a repair protein for DNA double-strand breaks, is cleaved by caspases during apoptosis. In this study, we examined the role of XRCC4 in apoptosis. Cell lines, derived from XRCC4-deficient M10 mouse lymphoma cells and stably expressing wild-type XRCC4 or caspase-resistant XRCC4, were established and treated with staurosporine (STS) to induce apoptosis. In STS-induced apoptosis, expression of wild-type, but not caspase-resistant, XRCC4 in XRCC4-deficient cells enhanced oligonucleosomal DNA fragmentation and the appearance of TUNEL-positive cells by promoting nuclear translocation of caspase-activated DNase (CAD), a major nuclease for oligonucleosomal DNA fragmentation...
December 9, 2017: Experimental Cell Research
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