keyword
https://read.qxmd.com/read/38652672/time-to-event-genome-wide-association-study-for-incident-cardiovascular-disease-in-people-with-type-2-diabetes
#1
JOURNAL ARTICLE
Soo Heon Kwak, Ryan B Hernandez-Cancela, Daniel A DiCorpo, David E Condon, Jordi Merino, Peitao Wu, Jennifer A Brody, Jie Yao, Xiuqing Guo, Fariba Ahmadizar, Mariah Meyer, Murat Sincan, Josep M Mercader, Sujin Lee, Jeffrey Haessler, Ha My T Vy, Zhaotong Lin, Nicole D Armstrong, Shaopeng Gu, Noah L Tsao, Leslie A Lange, Ningyuan Wang, Kerri L Wiggins, Stella Trompet, Simin Liu, Ruth J F Loos, Renae Judy, Philip H Schroeder, Natalie R Hasbani, Maxime M Bos, Alanna C Morrison, Rebecca D Jackson, Alexander P Reiner, JoAnn E Manson, Ninad S Chaudhary, Lynn K Carmichael, Yii-Der Ida Chen, Kent D Taylor, Mohsen Ghanbari, Joyce van Meurs, Achilleas N Pitsillides, Bruce M Psaty, Raymond Noordam, Ron Do, Kyong Soo Park, J Wouter Jukema, Maryam Kavousi, Adolfo Correa, Stephen S Rich, Scott M Damrauer, Catherine Hajek, Nam H Cho, Marguerite R Irvin, James S Pankow, Girish N Nadkarni, Robert Sladek, Mark O Goodarzi, Jose C Florez, Daniel I Chasman, Susan R Heckbert, Charles Kooperberg, Josée Dupuis, Rajeev Malhotra, Paul S de Vries, Ching-Ti Liu, Jerome I Rotter, James B Meigs
OBJECTIVE: To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD. RESULTS: Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18...
April 23, 2024: Diabetes Care
https://read.qxmd.com/read/38652144/-max-reger-and-his-early-death-could-it-have-been-avoided-would-he-have-lived-longer-with-adequate-intensive-care
#2
JOURNAL ARTICLE
Hans-Joachim Trappe
BACKGROUND: Max Reger was an organist, university teacher and composer whose life, illnesses, death and dying are not or hardly known to many. OBJECTIVES: Which illnesses determined Reger's life and did his lifestyle and illnesses influence his compositional work? Could his early death have been avoided? From today's point of view, could modern intensive care medicine have helped him? MATERIAL AND METHODS: A detailed analysis of Reger's diseases was performed using scientific databases (medline, pubmed)...
April 23, 2024: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://read.qxmd.com/read/38652086/hemodynamic-significance-of-coronary-anomalies-computed-tomography-based-fractional-flow-reserve-ct-ffr-as-an-adjudicator
#3
JOURNAL ARTICLE
Ilana Golub, Travis Benzing, Sina Kianoush, Srikanth Krishnan, Keishi Ichikawa, Matthew J Budoff
No abstract text is available yet for this article.
April 24, 2024: Coronary Artery Disease
https://read.qxmd.com/read/38651770/statin-initiation-after-myocardial-infarction-in-patients-with-alcohol-related-liver-disease-a-nationwide-population-based-study
#4
JOURNAL ARTICLE
Axel Wester, Peter Jepsen, Hannes Hagström
BACKGROUND AND AIMS: Secondary prevention with statins improves clinical outcomes after myocardial infarction (MI). We aimed to compare odds of statin initiation after MI in patients with co-existing alcohol-related liver disease (ALD) to the general population, and the association between statin initiation and mortality in the patients with ALD. METHODS: All statin-naïve patients with ALD and a first-time MI between 2006 and 2020 were identified from Swedish healthcare registers and matched for age, sex, and year of MI with up to ten ALD-free general population controls with a first-time MI...
April 23, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38651686/coronary-artery-calcification-and-high-volume-physical-activity-role-of-lower-intensity-versus-longer-duration-of-exercise
#5
JOURNAL ARTICLE
Andjelka Pavlovic, Laura F DeFina, David Leonard, Nina B Radford, Stephen W Farrell, Carolyn E Barlow, Kerem Shuval, Jarett D Berry, Benjamin D Levine
AIM: While high-volume physical activity (PA) has been linked to elevated coronary artery calcification (CAC), the role of intensity versus duration of PA has not been investigated. The purpose of the study was to examine the role of intensity versus duration of PA in relation to CAC. METHODS: Data are from 23,383 apparently healthy men who completed a PA questionnaire and underwent CAC scanning as part of a preventive exam. Self-reported PA was categorized into 4 groups of average intensity and weekly duration of PA and (average intensity: 1, 3-5...
April 23, 2024: European Journal of Preventive Cardiology
https://read.qxmd.com/read/38651405/early-and-long-term-results-of-simultaneous-and-staged-revascularization-of-coronary-and-carotid-arteries
#6
JOURNAL ARTICLE
Elena Golukhova, Igor Sigaev, Milena Keren, Inessa Slivneva, Bektur Berdibekov, Nina Sheikina, Olga Kozlova, Valery Arakelyan, Irina Volkovskaya, Tatiana Zavalikhina, Susanna Avakova
BACKGROUND: Carotid artery disease is prevalent among patients with coronary heart disease. The concomitant severe lesions in the carotid and coronary arteries may necessitate either simultaneous or staged revascularization involving coronary bypass and carotid endarterectomy. However, there is presently a lack of consensus on the optimal choice of surgical treatment tactics for patients with significant stenoses in both carotid and coronary arteries. The aim of the current study was to compare the 30-day and long-term outcomes of coronary and carotid artery revascularization surgery based on the simultaneous or staged surgical tactics...
April 13, 2024: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/38651080/artificial-intelligence-powered-insights-into-high-risk-non-obstructive-coronary-atherosclerosis-a-case-report
#7
Andrea Provera, Daniele Andreini, Kersten Petersen, Emanuele Gallinoro, Edoardo Conte
BACKGROUND: Advanced coronary plaque analysis by cardiac computed tomography (CT) has recently emerged as a promising technique for better prognostic stratification. However, this evaluation application in clinical practice is still uncertain. CASE SUMMARY: In the present case, we described the clinical picture of a 44-year-old tennis player with ectopic ventricular beats in which cardiac CT enabled the identification of a non-obstructive but high-risk plaque on proximal left anterior descendent artery...
April 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38650792/impact-of-clinical-and-sociodemographic-factors-on-quality-of-life-following-coronary-artery-bypass-grafting-a-mixed-methods-study
#8
JOURNAL ARTICLE
Abdulmajeed A Alzahrani, Abdullah K AlAssiri, Khalid E Al-Ebrahim, Zeyad T Ganbou, Meshal M Alsudais, Abdulmajeed M Khafagy
INTRODUCTION: Coronary artery bypass grafting (CABG) is an essential surgical management modality for patients with coronary artery disease. Health-related quality of life (HRQoL) has become important because of the significant decrease in the mortality rate associated with CABG. We aimed to explore the factors that affect the quality of life after CABG. METHODS: This study used a descriptive correlational design to assess the determinants of HRQoL using the 36-item Short Form Health Survey questionnaire (SF-36)...
March 2024: Curēus
https://read.qxmd.com/read/38650729/safety-and-efficacy-of-direct-oral-anticoagulants-in-comparison-to-warfarin-in-obese-patients-with-atrial-fibrillation-a-systematic-review-and-meta-analysis
#9
JOURNAL ARTICLE
Alla Adelkhanova, Prakash Raj Oli, Dhan Bahadur Shrestha, Jurgen Shtembari, Vivek Jha, Ghanshyam Shantha, George Michael Bodziock, Monodeep Biswas, Muhammad Omer Zaman, Nimesh K Patel
BACKGROUND AND AIM: Obesity affects nearly 650 million adults worldwide, and the prevalence is steadily rising. This condition has significant adverse effects on cardiovascular health, increasing the risk of hypertension, coronary artery disease, heart failure, and atrial fibrillation (AF). While anticoagulation for obese patients with AF is a well-established therapy for the prevention of thromboembolism, the safety and efficacy of different anticoagulants in this specific population are not well explored...
April 2024: Health Science Reports
https://read.qxmd.com/read/38650543/economic-and-healthcare-resource-utilization-assessments-of-pet-imaging-in-coronary-artery-disease-diagnosis-a-systematic-review-and-discussion-of-opportunities-for-future-economic-evaluations
#10
JOURNAL ARTICLE
Nicole Ferko, Stacey Priest, Lamees Almuallem, Alicyia Walczyk Mooradally, Di Wang, Abril Oliva Ramirez, Erika Szabo, Arturo Cabra
Aims: This systematic literature review (SLR) consolidated economic and healthcare resource utilization (HCRU) evidence for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) to inform future economic evaluations. Materials and Methods: An electronic search was conducted in MEDLINE, Embase, and Cochrane databases from 2012-2022. Economic and HCRU studies in adults who underwent PET- or SPECT-MPI for coronary artery disease (CAD) diagnosis were eligible...
April 23, 2024: Journal of Medical Economics
https://read.qxmd.com/read/38650518/tapse-spap-prognostic-value-for-in-hospital-adverse-events-in-patients-hospitalized-for-acute-coronary-syndrome
#11
JOURNAL ARTICLE
Charles Fauvel, Jean-Guillaume Dillinger, Claire Bouleti, Antonin Trimaille, Christophe Tron, Anne Solene Chaussade, Christophe Thuaire, Clément Delmas, Albert Boccara, Vincent Roule, Damien Millischer, Eugénie Thevenet, Christophe Meune, Mathilde Stevenard, Clément Charbonnel, Laura Maitre Ballesteros, Thibaut Pommier, Amine El Ouahidi, Fédérico Swedsky, David Martinez, Marie Hauguel-Moreau, Guillaume Schurtz, Augustin Coisne, Valentin Dupasquier, Thomas Bochaton, Edouard Gerbaud, Etienne Puymirat, Patrick Henry, Théo Pezel
AIMS: Although several studies have shown that the right ventricular to pulmonary artery (RV-PA) coupling, assessed by the ratio between tricuspid annular plane systolic excursion and systolic pulmonary artery pressure (TAPSE/sPAP) using echocardiography, is strongly associated with cardiovascular events, its prognostic value is not established in acute coronary syndrome (ACS). We aimed to assess the in-hospital prognostic value of TAPSE/sPAP among patients hospitalized for ACS in a retrospective analysis from the prospective ADDICT-ICCU study...
April 23, 2024: European Heart Journal Cardiovascular Imaging
https://read.qxmd.com/read/38650385/cardiac-hemodynamics-phenotypes-and-individual-responses-to-training-in-coronary-heart-disease-patients
#12
JOURNAL ARTICLE
Marine Kirsch, Damien Vitiello, Lukas-Daniel Trachsel, Maxime Boidin, Julie Lalongé, Martin Juneau, Louis Bherer, Anil Nigam, Mathieu Gayda
BACKGROUND: In patients with coronary heart disease (CHD), individualized exercise training (ET) programs are strongly recommended to optimize peak oxygen uptake ( <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"> <mml:semantics> <mml:mrow><mml:mover><mml:mi>V</mml:mi> <mml:mo>̇</mml:mo></mml:mover> </mml:mrow> <mml:annotation>$$ \dot{\mathrm{V}} $$</mml:annotation></mml:semantics> </mml:math> O2peak ) improvement and prognosis...
April 2024: Scandinavian Journal of Medicine & Science in Sports
https://read.qxmd.com/read/38650162/e-selectin-is-associated-with-stable-angina-and-myocardial-infarction-in-a-sample-of-kurdish-population
#13
JOURNAL ARTICLE
Lajan Qasim Rahman, Ruqaya Muhammad Ghareeb
Endothelial dysfunction is the main factor that causes the onset of CAD. Leukocyte adhesion to the endothelium of the active blood artery wall has been demonstrated to be one of the early indicators of arteriosclerosis. This process is regulated by selectins. The purpose of this study is to ascertain the relationship between the polymorphisms in the E-selectin gene that have been linked to ischemic heart disease. We looked at the functional impact of the E-selectin gene polymorphism 7170G>C in Iraqi patients with IHD...
March 31, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38650038/association-between-diabetes-mellitus-and-primary-restenosis-following-endovascular-treatment-a-comprehensive-meta-analysis-of-randomized-controlled-trials
#14
JOURNAL ARTICLE
Xiaolei Sun, Cheng Zhang, Yarong Ma, Yanzheng He, Xiaodong Zhang, Jianbo Wu
IMPORTANCE: Diabetes mellitus (DM) is thought to be closely related to arterial stenotic or occlusive disease caused by atherosclerosis. However, there is still no definitive clinical evidence to confirm that patients with diabetes have a higher risk of restenosis. OBJECTIVE: This meta-analysis was conducted to determine the effect of DM on restenosis among patients undergoing endovascular treatment, such as percutaneous transluminal angioplasty (PTA) or stenting...
April 22, 2024: Cardiovascular Diabetology
https://read.qxmd.com/read/38649122/rapid-progression-of-a-coronary-artery-aneurysm-caused-by-igg4-related-disease
#15
Yohei Miura, Kohei Koyama, Takashi Kohno, Kyoko Soejima, Sho Torii, Gaku Nakazawa
BACKGROUND: IgG4-related disease (IgG4-RD) is a recently recognized fibro-inflammatory disorder that can affect almost any organ. IgG4-RD has also been reported in coronary arteries as periarteritis. IgG4-related coronary periarteritis may cause coronary artery aneurysms, and IgG4-related coronary artery aneurysms (IGCAs) are life-threatening. We describe a case of a patient with IGCA that highlights the usefulness and limitations of various IGCA evaluation modalities and provides insight into disease pathophysiology...
April 20, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38649068/the-causal-relationship-between-metabolic-syndrome-and-its-components-and-cardiovascular-disease-a-mendelian-randomization-study-causal-relationship-between-mets-and-cvds
#16
JOURNAL ARTICLE
Zejia Wu, Songyuan Luo, Dongqin Cai, Wenhui Lin, Xiaolu Hu, Ting Zhou, Xuxing Zhang, Yingqing Feng, Jianfang Luo
AIM: To investigate the causal relationship between metabolic syndrome (MetS) and its components and 14 cardiovascular diseases using Mendelian randomization (MR). METHODS: We used summary statistics from large-scale genome-wide association studies of MetS, its components, and cardiovascular diseases. We performed a two-sample MR analysis using the inverse-variance weighted method and other sensitivity methods. We also performed multivariate MR to adjust for potential risk factors...
April 20, 2024: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/38648775/prevalence-and-progression-of-arterial-calcifications-on-computed-tomography-in-humans-with-knee-osteoarthritis
#17
JOURNAL ARTICLE
Pim A de Jong, Netanja I Harlianto, Wouter Foppen, Nağme Ö Renkli, Wilko Spiering, Harrie Weinans, Willem PThM Mali, Simon C Mastbergen, Mylène P Jansen
OBJECTIVES: Ectopic bone deposition plays an important role in osteoarthritis (OA) and in arterial wall disease. We aimed to investigate the prevalence and progression of arterial calcifications on whole-body computed tomography (CT) in persons with knee OA. METHODS: We included 118 (36 male) participants who satisfied the clinical American College of Rheumatology classification criteria for knee OA. Baseline investigations included Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Kellgren-Lawrence grading...
April 22, 2024: Rheumatology
https://read.qxmd.com/read/38648275/much-ado-about-nothing-cabg-or-pci-for-left-main-coronary-artery-disease
#18
EDITORIAL
Jay Giri, Tsuyoshi Kaneko
No abstract text is available yet for this article.
April 23, 2024: Circulation
https://read.qxmd.com/read/38648103/effectiveness-of-an-interactive-mhealth-app-evite-in-improving-lifestyle-after-a-coronary-event-randomized-controlled-trial
#19
JOURNAL ARTICLE
María Ángeles Bernal-Jiménez, German Calle, Alejandro Gutiérrez Barrios, Livia Luciana Gheorghe, Celia Cruz-Cobo, Nuria Trujillo-Garrido, Amelia Rodríguez-Martín, Josep A Tur, Rafael Vázquez-García, María José Santi-Cano
BACKGROUND: Coronary heart disease is one of the leading causes of mortality worldwide. Secondary prevention is essential, as it reduces the risk of further coronary events. Mobile health (mHealth) technology could become a useful tool to improve lifestyles. OBJECTIVE: This study aimed to evaluate the effect of an mHealth intervention on people with coronary heart disease who received percutaneous coronary intervention. Improvements in lifestyle regarding diet, physical activity, and smoking; level of knowledge of a healthy lifestyle and the control of cardiovascular risk factors (CVRFs); and therapeutic adherence and quality of life were analyzed...
April 22, 2024: JMIR MHealth and UHealth
https://read.qxmd.com/read/38648028/hemodynamic-reactivity-to-mental-stress-and-cognitive-function-in-coronary-artery-disease
#20
JOURNAL ARTICLE
Kasra Moazzami, Ambar Kulshreshtha, Matthew Gold, Alireza Rahbar, Felicia Goldstein, Amit J Shah, J Douglas Bremner, Viola Vaccarino, Arshed A Quyyumi
OBJECTIVE: People with coronary artery disease (CAD) are at higher risk of cognitive impairment than those without CAD. Psychological stress is a risk factor for both conditions and assessing the hemodynamic reactivity to mental stress could explain the link between stress and cognitive function. METHODS: Individuals with stable CAD from two prospective cohort studies were included. All individuals underwent acute mental stress testing, as well as conventional stress testing...
April 16, 2024: Psychosomatic Medicine
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