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https://www.readbyqxmd.com/read/29452170/expression-and-significance-of-sirt1-in-renal-allografts-at-the-early-stage-of-chronic-renal-allograft-dysfunction
#1
Yue Xia, Jin Deng, Qin Zhou, Xiaofei Shao, Xingyan Yang, Mengjiao Shao, Hequn Zou
OBJECTIVE: To investigate the expression and significance of Sirt1 in renal allografts at the early stage of chronic renal allograft dysfunction (CRAD). METHODS: CRAD rat models were established using classical orthotopic F344-Lewis kidney transplantation. F344 and Lewis uninephrectomized rats were used as controls. Twelve weeks after the operation, the rats were sacrificed for renal function, histological, immunohistochemistry and molecular biological analyses...
February 13, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29445015/influence-of-ageing-on-quantitative-contrast-enhanced-ultrasound-of-the-kidneys-in-healthy-cats
#2
Emmelie Stock, Dominique Paepe, Sylvie Daminet, Luc Duchateau, Jimmy H Saunders, Katrien Vanderperren
The degenerative effects of ageing on the kidneys have been extensively studied in humans. However, only recently interest has been focused on renal ageing in veterinary medicine. Contrast-enhanced ultrasound allows non-invasive evaluation of renal perfusion in conscious cats. Renal perfusion parameters were obtained in 43 healthy cats aged 1-16 years old, and the cats were divided in four age categories: 1-3 years, 3-6 years, 6-10 years and over 10 years. Routine renal parameters as serum creatinine, serum urea, urine-specific gravity, urinary protein:creatinine ratio and systolic blood pressure were also measured...
February 14, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29431364/chronic-kidney-disease-detection-and-evaluation
#3
David Y Gaitonde, David L Cook, Ian M Rivera
Chronic kidney disease affects 47 million people in the United States and is associated with significant health care costs, morbidity, and mortality. Because this disease can silently progress to advanced stages, early detection is critical for initiating timely interventions. Multiple guidelines recommend at least annual screening with serum creatinine, urine albumin/creatinine ratio, and urinalysis for patients with risk factors, particularly diabetes mellitus, hypertension, and a history of cardiovascular disease...
December 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29427024/comparison-of-the-effects-of-linagliptin-and-voglibose-on-endothelial-function-in-patients-with-type-2-diabetes-and-coronary-artery-disease-a-prospective-randomized-pilot-study-effort
#4
Taku Koyama, Atsushi Tanaka, Hisako Yoshida, Jun-Ichi Oyama, Shigeru Toyoda, Masashi Sakuma, Teruo Inoue, Yoritaka Otsuka, Koichi Node
Endothelial dysfunction contributes to poor cardiovascular prognosis in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). The effect of dipeptidyl peptidase-4 inhibitors on endothelial function remains controversial. We sought to compare the effects of linagliptin and voglibose on endothelial function, as assessed by reactive hyperemia-peripheral arterial tonometry (RH-PAT). Sixteen patients with newly diagnosed T2DM and CAD were randomized 1:1 to linagliptin (5 mg, once-daily) or voglibose (0...
February 9, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29423043/greater-low-density-lipoprotein-cholesterol-variability-is-associated-with-increased-progression-to-dialysis-in-patients-with-chronic-kidney-disease-stage-3
#5
Yu-Hsuan Lin, Jiun-Chi Huang, Pei-Yu Wu, Szu-Chia Chen, Yi-Wen Chiu, Jer-Ming Chang, Hung-Chun Chen
Increasing evidence suggests that lipid variability may be a predictor of cardiovascular events. However, few studies have evaluated the association between lipid variability and renal outcomes in patients with moderate-to-advanced chronic kidney disease (CKD). Therefore, the aims of this study were to assess whether lipid variability is associated with progression to dialysis in patients with CKD stage 3-5, and to evaluate the risk factors of lipid variability. This longitudinal study enrolled 725 patients with CKD stage 3-5...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29414320/urine-epidermal-growth-factor-monocyte-chemoattractant-protein-1-or-their-ratio-as-predictors-of-complete-remission-in-primary-glomerulonephritis
#6
Eakkapat Chanrat, Supanat Worawichawong, Piyanuch Radinahamed, Nuankanya Sathirapongsasuti, Arkom Nongnuch, Montira Assanatham, Umaporn Udomsubpayakul, Chagriya Kitiyakara
BACKGROUND: The balance of several cytokines likely influences the resolution of glomerulonephritis. Monocyte chemoattractant protein-1(MCP-1) is a chemokine that promotes renal inflammation whereas epidermal growth factor (EGF) stimulates protective responses. Previously, high urine MCP-1(MCP-1) and low urine EGF (EGF) levels were found to be associated with tubulointerstitial fibrosis, but there is limited information on the value of these mediators as predictors of therapeutic responses or long term outcome in primary glomerulonephritis...
January 31, 2018: Cytokine
https://www.readbyqxmd.com/read/29412698/the-organic-anion-transporter-oat3-enhances-the-glucosuric-effect-of-the-sglt2-inhibitor-empagliflozin
#7
Yiling Fu, Davorka Breljak, Akira Onishi, Falk Batz, Rohit Patel, Winnie Huang, Panai Song, Brent Freeman, Eric Mayoux, Hermann Koepsell, Naohiko Anzai, Sanjay K Nigam, Ivan Sabolić, Volker Vallon
The SGLT2 inhibitor empagliflozin (plasma protein binding ~88%) may reach its target in the brush border of the early proximal tubule by glomerular filtration and tubular secretion. Here we determined whether empagliflozin is secreted by renal tubules, and whether genetic knockout of the basolateral organic anion transporter Oat3 (-/-) affects its tubular secretion or glucosuric effect. Renal clearance studies in wild-type (WT) mice showed that tubular secretion accounted for 50-70% of empagliflozin urinary excretion...
February 7, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29410298/renal-outcomes-in-primary-iga-nephropathy-patients-with-segmental-glomerular-necrosis-a-case-control-study
#8
Min Pan, Ji Zhang, Xiaohan You, Duo Li, Yinqiu Lv, Jianna Zhang, Xiaokai Ding, Zhanyuan Li, Feifei Xu, Chaosheng Chen
The renal prognosis and treatment of primary IgA nephropathy (IgAN) patients with segmental glomerular necrosis (SGN) remain controversial. Patients with primary IgAN confirmed by renal biopsy were enrolled. Patients with SGN on renal biopsy were selected as the necrosis group, and a propensity score matching method was used to match a control group according to age, gender, weight, height and follow-up time. A total of 825 IgAN patients were enrolled in the present study. Seventy-three (8.8%) patients with SGN were selected as the necrosis group, and 292 patients without SGN were matched as the control group...
February 1, 2018: Human Pathology
https://www.readbyqxmd.com/read/29386973/serum-vascular-endothelial-growth-factor-vegf-as-a-biomarker-for-disease-activity-in-lupus-nephritis
#9
Wan Syamimee Wan Ghazali, Rahimah Iberahim, Noor Suryani Mohd Ashari
Background: Previous studies have shown that serum VEGF levels were elevated in patients with active systemic lupus erythematosus (SLE), especially in those with lupus nephritis (LN). In this case control study, we aimed to compare serum levels of VEGF in SLE patients between LN, non-LN and healthy participants to determine the association between serum VEGF levels and the activity and histological classes of lupus nephritis. Methods: Blood samples were obtained from 92 SLE patients (46 LN and 46 non-LN) and 26 controls...
October 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/29381664/hormone-therapy-and-urine-protein-excretion-a-multiracial-cohort-study-systematic-review-and-meta-analysis
#10
Andrea G Kattah, Maria L G Suarez, Natasa Milic, Kejal Kantarci, Burcu Zeydan, Thomas Mosley, Stephen T Turner, Erin B Ware, Sharon L R Kardia, Vesna D Garovic
OBJECTIVE: Experimental models suggest estrogen has a renoprotective effect, but human studies show variable results. Our objective was to study the association of hormone therapy (HT) and albuminuria in postmenopausal women and to synthesize the results with outcomes from prior studies. METHODS: We analyzed data from postmenopausal women who participated in the second study visit (2000-2004) of the Genetic Epidemiology Network of Arteriopathy (GENOA) study. The exposure was self-reported HT use and the outcome was albuminuria (urine albumin-to-creatinine ratio >25 mg/g creatinine)...
January 29, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29368537/superior-efficacy-and-improved-renal-and-bone-safety-after-switching-from-a-tenofovir-disoproxil-fumarate-tdf-to-a-tenofovir-alafenamide-taf-based-regimen-through-96-weeks-of-treatment
#11
Edwin DeJesus, Bernard Haas, Sorana Segal-Mauer, Moti Ramgopal, Anthony Mills, Nicolas Margot, Ya-Pei Liu, Tariro Makadzange, Scott McCallister
BACKGROUND: We previously demonstrated superior efficacy and safety advantages in HIV-infected, virologically suppressed adults switched to a regimen containing tenofovir alafenamide (TAF) as compared with those remaining on a tenofovir disoproxil fumarate (TDF) regimen through week 48. We now report longer-term data through week 96. METHODS: In this randomized, active-controlled, multicenter, open-label, non-inferiority trial (ClinicalTrials.gov number NCT01815736), we randomized virologically suppressed (HIV-1 RNA <50 copies/mL) adults (2:1) to receive a once-daily, single-tablet regimen containing elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide (TAF group) or to continue one of four TDF-containing regimens (TDF group) for 96 weeks...
January 25, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29367427/high-baseline-levels-of-tumor-necrosis-factor-receptor-1-are-associated-with-progression-of-kidney-disease-in-indigenous-australians-with-diabetes-the-egfr-follow-up-study
#12
Elizabeth L M Barr, Federica Barzi, Jaquelyne T Hughes, George Jerums, Wendy E Hoy, Kerin O'Dea, Graham Jones, Paul D Lawton, Alex D H Brown, Mark Thomas, Elif I Ekinci, Ashim Sinha, Alan Cass, Richard J MacIsaac, Louise J Maple-Brown
OBJECTIVE: To examine the association between soluble tumor necrosis factor receptor 1 (sTNFR1) levels and kidney disease progression in Indigenous Australians at high risk of kidney disease. RESEARCH DESIGN AND METHODS: This longitudinal observational study examined participants aged ≥18 years recruited from >20 sites across diabetes and/or kidney function strata. Baseline measures included sTNFR1, serum creatinine, urine albumin-to-creatinine ratio (uACR), HbA1c, C-reactive protein (CRP), waist-to-hip ratio, systolic blood pressure, and medical history...
January 24, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29366580/urinary-biomarkers-may-provide-prognostic-information-for-subclinical-acute-kidney-injury-after-cardiac-surgery
#13
Christian Albert, Annemarie Albert, Johanna Kube, Rinaldo Bellomo, Nicholas Wettersten, Hermann Kuppe, Sabine Westphal, Michael Haase, Anja Haase-Fielitz
OBJECTIVE: This study aimed to determine the biomarker-specific outcome patterns and short-and long-term prognosis of cardiac surgery-asoociated acute kidney injury (AKI) identified by standard criteria and/or urinary kidney biomarkers. METHODS: Patients enrolled (N = 200), originated a German multicenter study (NCT00672334). Standard risk injury, failure, loss, and end-stage renal disease classification (RIFLE) criteria (including serum creatinine and urine output) and urinary kidney biomarker test result (neutrophil gelatinase-associated lipocalin, midkine, interleukin 6, and proteinuria) were used for diagnosis of postoperative AKI...
December 22, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29357806/correlation-between-white-blood-cell-count-and-insulin-resistance-in-type-2-diabetes-running-title-wbc-and-insulin-resistance
#14
Armin Mahdiani, Masoume Kheirandish, Shokoufeh Bonakdaran
BACKGROUND: The role of chronic inflammation in insulin resistance states and the pathogenesis of metabolic syndrome, cardiovascular disease and diabetes have been reported earlier. White blood cell (WBC) count is an easy marker for estimation of systemic inflammation. OBJECTIVE: This study is to clarify whether WBC count associate with insulin resistance in type 2 diabetic patients. METHOD: This cross sectional study was conducted in 283 patients with type 2 diabetes and in 283 healthy non diabetic subjects as control group...
January 19, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29355892/the-effect-of-ethnicity-on-the-performance-of-protein-creatinine-ratio-in-the-prediction-of-significant-proteinuria-in-pregnancies-at-risk-of-or-with-established-hypertension-an-implementation-audit-and-cost-implications
#15
Sadia Bhatti, Mark Cordina, Leonie Penna, Roy Sherwood, Tracy Dew, Nikos A Kametas
INTRODUCTION: The replacement of 24-hour urine collection by protein-creatinine ratio (PCR) for the diagnosis of pre-eclampsia has been recently recommended. However, the literature is conflicting and there are concerns on the impact of demographic characteristics on the performance of PCR. MATERIALS AND METHODS: This was an implementation audit of the introduction of PCR in a London Tertiary obstetric unit. The performance of PCR in the prediction of proteinuria ≥300mg/day was assessed in 476 women with suspected pre-eclampsia who completed a 24-hour urine collection and an untimed urine sample for PCR calculation...
January 21, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29353206/dihydroartemisinin-ameliorates-sepsis-induced-hyperpermeability-of-glomerular-endothelium-via-up-regulation-of-occludin-expression
#16
Zuowang Cheng, Ruixia Qi, Liqun Li, Qiang Liu, Wenqian Zhang, Xia Zhou, Dongmei Xu, Thaddeus D Allen, Silin Pan, Ju Liu
Sepsis, the systemic inflammatory responses after infection, remains a serious cause of morbidity and mortality in critically ill patients. The anti-malarial agent dihydroartemisinin (DHA) has been shown to be anti-inflammatory. In this study, we examined the effects of DHA on sepsis-induced acute kidney injury (AKI) and explored the mechanism underlying its mode of action in AKI. In a lipopolysaccharide (LPS)-induced mouse model, we observed that DHA treatment ameliorated glomerular injury, and relieved elevation of the urine albumin to creatinine ratio (UACR) and serum creatinine...
January 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29340321/randomized-clinical-trial-design-to-assess-abatacept-in-resistant-nephrotic-syndrome
#17
Howard Trachtman, Debbie S Gipson, Michael Somers, Cathie Spino, Sharon Adler, Lawrence Holzman, Jeffrey B Kopp, John Sedor, Sandra Overfield, Ayanbola Elegbe, Michael Maldonado, Anna Greka
Introduction: Treatment-resistant nephrotic syndrome is a rare form of glomerular disease that occurs in children and adults. No Food and Drug Administration-approved treatments consistently achieve remission of proteinuria and preservation of kidney function. CD80 (B7-1) can be expressed on injured podocytes, and administration of abatacept (modified CTLA4-Ig based on a natural ligand to CD80) has been associated with sustained normalization of urinary protein excretion and maintenance of glomerular filtration rate in experimental and clinical settings...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29325582/urinary-angiostatin-cxcl4-and-vcam-1-as-biomarkers-of-lupus-nephritis
#18
Chi Chiu Mok, Samar Soliman, Ling Yin Ho, Fatma A Mohamed, Faten Ismail Mohamed, Chandra Mohan
BACKGROUND: The aim was to study urinary angiostatin, CXC chemokine ligand 4 (CXCL4) and vascular cell adhesion molecule-1 (VCAM-1) as biomarkers of renal disease in systemic lupus erythematosus (SLE). METHOD: Patients who fulfilled ≥ 4 American College of Rheumatology (ACR) criteria for SLE with active renal, active non-renal or inactive disease, and a group of healthy controls were studied. Urine samples were assayed for angiostatin, CXCL4 and VCAM-1 by ELISA, and normalized by creatinine...
January 11, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29319493/cyclosporine-for-the-treatment-of-lupus-nephritis-in-patients-with-systemic-lupus-erythematosus
#19
Tzu-Han Yang, Tsai-Hung Wu, Yuh-Lih Chang, Hsien-Tzung Liao, Chia-Chen Hsu, Chang-Youh Tsai, Yueh-Ching Chou
AIMS: This study aimed to assess retrospectively the efficacy and safety of cyclosporin A (CsA) therapy in patients with lupus nephritis (LN). MATERIALS AND METHODS: From September 2005 to August 2015, eligible patients with LN undergoing CsA treatment were enrolled in the study. Medical charts as well as clinical and laboratory data were retrospectively reviewed. The data were evaluated at 0, 1, 6, 12 month(s) after the start of CsA. Serum creatinine (SCr), estimated glomerular filtration rate (eGFR), urine protein/creatinine ratio (uPCR), complement components C3, C4, and anti-double stranded DNA antibody (anti-dsDNA) titers were recorded...
January 10, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29311252/pazopanib-induced-hypertension-in-patients-with-renal-cell-carcinoma-is-associated-with-low-urine-excretion-of-no-metabolites
#20
Anne Robdrup Tinning, Camilla Bengtsen, Niels Viggo Jensen, Lars Bastholt, Boye Lagerbon Jensen, Kirsten Madsen
Drugs targeting VEGF (vascular endothelial growth factor) are often associated with rapid development of hypertension by a yet not fully understood mechanism. VEGF is expressed in renal epithelial cells and stimulates NO production. In the renal medulla, inhibition of NO formation by local L-NAME or by impaired endothelin-1 leads to hypertension. The present study was designed to test the hypothesis that VEGF receptor inhibitor treatment leads to hypertension through decreased renal medullary formation of NO and endothelin-1...
January 8, 2018: Hypertension
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