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proteín creatinine ratio in urine

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https://www.readbyqxmd.com/read/29242046/the-feasibility-and-acceptability-of-self-testing-for-proteinuria-during-pregnancy-a-mixed-methods-approach
#1
Katherine L Tucker, Liza Bowen, Carole Crawford, Philippa Mallon, Lisa Hinton, Mei-Man Lee, Jason Oke, Kathryn S Taylor, Carl Heneghan, Clare Bankhead, Lucy Mackillop, Tim James, Pippa Oakeshott, Lucy C Chappell, Richard J McManus
OBJECTIVE: To investigate feasibility and acceptability of self-testing for proteinuria during pregnancy. STUDY DESIGN: Mixed methods approach which included: an accuracy study where pregnant women (n = 100) and healthcare professionals (n = 96) tested seven synthetic protein samples and completed a questionnaire, a feasibility study where pregnant women who were self-monitoring their blood pressure were asked to self-test for proteinuria (n = 30), and an online questionnaire about women's experiences of self-testing (n = 200)...
November 23, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29236656/secondary-syphilis-associated-with-membranous-nephropathy-and-acute-hepatitis-in-a-patient-with-hiv-a-case-report
#2
Zhou Zhang, Aviv Hever, Nitin Bhasin, Dean A Kujubu
INTRODUCTION: We present a case of membranous nephropathy associated with a secondary syphilis infection in a patient with HIV. CASE PRESENTATION: A 37-year-old white man with HIV who was receiving highly active antiretroviral therapy presented to the Emergency Department with 6 weeks of rectal pain. He had a CD3-CD4 count of 656 cells/mm3 and an undetectable viral load. On admission, he was found to have an anal ulcer, a serum creatinine of 1.4 mg/dL (baseline 0...
2017: Permanente Journal
https://www.readbyqxmd.com/read/29214037/correlation-of-hypogammaglobulinaemia-with-proteinuria-and-the-relationship-between-hypogammaglobulinaemia-and-infection-in-active-lupus-nephritis
#3
Dawn Elaine Smilek, Noha Lim, Linna Ding, Sara G Murray, Betty Diamond, David Wofsy
Objective: To evaluate hypogammaglobulinaemia and risk of serious infectious adverse events in active lupus nephritis. Methods: The Abatacept and Cyclophosphamide Combination Efficacy and Safety Study (ACCESS) compared abatacept with placebo in participants with lupus nephritis undergoing treatment with Euro-Lupus Nephritis low-dose cyclophosphamide. Serum IgG levels were assessed prior to initiation of treatment and throughout the trial. Hypogammaglobulinaemia was defined as IgG <450 mg/dL...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29208969/association-of-kidney-fibrosis-with-urinary-peptides-a-path-towards-non-invasive-liquid-biopsies
#4
Pedro Magalhães, Martin Pejchinovski, Katerina Markoska, Miroslaw Banasik, Marian Klinger, Dominika Švec-Billá, Ivan Rychlík, Merita Rroji, Arianna Restivo, Giovambattista Capasso, Flaviu Bob, Adalbert Schiller, Alberto Ortiz, Maria Vanessa Perez-Gomez, Pablo Cannata, Maria Dolores Sanchez-Niño, Radomir Naumovic, Voin Brkovic, Momir Polenakovic, William Mullen, Antonia Vlahou, Petra Zürbig, Lars Pape, Franco Ferrario, Colette Denis, Goce Spasovski, Harald Mischak, Joost P Schanstra
Chronic kidney disease (CKD) is a prevalent cause of morbidity and mortality worldwide. A hallmark of CKD progression is renal fibrosis characterized by excessive accumulation of extracellular matrix (ECM) proteins. In this study, we aimed to investigate the correlation of the urinary proteome classifier CKD273 and individual urinary peptides with the degree of fibrosis. In total, 42 kidney biopsies and urine samples were examined. The percentage of fibrosis per total tissue area was assessed in Masson trichrome stained kidney tissues...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29203938/short-term-effects-of-dietary-supplementation-with-amino-acids-in-dogs-with-proteinuric-chronic-kidney-disease
#5
Andrea Zatelli, Paola D'Ippolito, Xavier Roura, Eric Zini
This retrospective study investigated the impact of amino acid supplementation on body weight, serum albumin, creatinine and urea concentrations, and urine protein-to-creatinine (UPC) ratio in proteinuric dogs with chronic kidney disease (CKD). Forty-six client-owned azotemic dogs with spontaneous proteinuric CKD already on a renal diet and in therapy with enalapril were included. After approximately 1 month of treatment (baseline), 29 dogs received oral amino acid supplementation daily (group A) and 17 dogs did not (group B)...
December 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29194759/association-between-urine-retinol-binding-protein-levels-and-nonalcoholic-fatty-liver-disease-a-cross-sectional-study-in-chinese-population
#6
Juanwen Zhang, Zeyu Liu, Xuyao Zhang, Li Zhang, Xi Jin
OBJECTIVE: The prevalence of nonalcoholic fatty liver disease (NAFLD) has been rapidly increased, becoming a public health problem worldwide. Our objective was to investigate the association between urine retinol-binding protein (RBP) and NAFLD in a Chinese population and develop a multivariate logistic regression model for NAFLD prediction. METHODS: A total of 317 NAFLD patients and 391 healthy controls were enrolled in this cross-sectional study based on inclusion and exclusion criteria, from whom fasting urine and blood were collected for further study...
November 30, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29193639/oligonephronia-and-wolf-hirschhorn-syndrome-a-further-observation
#7
Antonio Gatto, Pietro Ferrara, Chiara Leoni, Roberta Onesimo, Marcella Zollino, Francesco Emma, Giuseppe Zampino
Wolf-Hirschhorn syndrome (WHS) is a rare chromosomal disorder caused by a partial deletion of chromosome 4 (4p16.3p16.2). We describe a case of a male 9 years old children with WHS proteinuria and hypertension. Laboratory data showed creatinine 1.05 mg/dl, GFR 65.9 ml/min/1.73 m2 , cholesterol 280 mg/dl, triglyceride 125 mg/dl with electrolytes in the normal range. Urine collection showed protein 2.72 g/L with a urine protein/creatinine ratio (UP /UCr ratio) of 4.2 and diuresis of 1,100 ml. Renal ultrasound showed reduced kidney dimensions with diffusely hyperechogenic cortex and poorly visualized pyramids...
November 28, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29191133/focal-segmental-glomerulosclerosis-in-related-miniature-schnauzer-dogs
#8
Wilson Yau, Lisa Mausbach, Meryl P Littman, Rachel E Cianciolo, Cathy A Brown
Focal segmental glomerulosclerosis (FSGS) recently has been recognized as a common cause of proteinuria in dogs in general, and in Miniature Schnauzer dogs in particular. This study describes the morphologic features present in the kidneys of 8 related proteinuric Miniature Schnauzer dogs. The FSGS, characterized by solidification of portions of the capillary tuft, affected 32% to 49% of examined glomeruli in these dogs. Synechiae, often accompanied by hyalinosis, were present in 13% to 54% of glomeruli and were more prevalent in older dogs...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/29180849/adjuvant-immunotherapy-of-dendritic-cells-and-cytokine-induced-killer-cells-is-safe-and-enhances-chemotherapy-efficacy-for-multiple-myeloma-in-china-a-meta-analysis-of-clinical-trials
#9
Yan Wang, Benji Lv, Ke Li, Anqi Zhang, Hong Liu
Objective: The aim of this study was to systematically evaluate the efficacy and safety of the combination of dendritic cells and cytokine-induced killer cells (DC-CIK) adjuvant immunotherapy and chemotherapy in the treatment of multiple myeloma (MM). Methods: Clinical trials were gathered by searching Web of Science, PubMed, Embase, Cochrane Library, Wanfang, and CNKI database. Outcome measurements including therapeutic efficacy, prognosis, immune function, and adverse events were extracted and evaluated...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29178575/serum-iga-c3-and-glomerular-c3-staining-predict-severity-of-iga-nephropathy
#10
Yukihiko Kawasaki, Ryo Maeda, Shinichiro Ohara, Kazuhide Suyama, Mitsuaki Hosoya
BACKGROUND: We evaluated whether the serum IgA/C3 ratio and glomerular C3 staining predict prognosis in IgA nephropathy. METHODS: We collected data for 44 IgA nephropathy children treated with multi-drug combination therapy. The children were retrospectively divided into four groups based on the serum IgA/C3 ratio and glomerular C3 staining. Group A consisted of 9 children with a higher than median IgA/C3 ratio and glomerular C3 staining ≧2.0, Group B consisted of 7 children with a higher than median IgA/C3 ratio and glomerular C3 staining <2...
November 27, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29177060/predictors-of-incident-proteinuria-among-patients-with-sle
#11
Alí Duarte-García, Erik Barr, Laurence S Magder, Michelle Petri
Objective: To identify fixed and time-varying predictors of incident proteinuria. Methods: This analysis was based on patients who did not have a history of diabetes and who did not have a prior episode of renal involvement. We defined an incident case of proteinuria as two or more measures of urine protein to creatinine ratio (or 24-hour protein measure) greater than 0.5 in two visits separated by more than 30 days and less than 180 days. We estimated rates of incident proteinuria in subgroups of patients with lupus defined by time-invariant and time-varying predictors...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29177052/biomarkers-of-tubulointerstitial-damage-and-function-in-type-1-diabetes
#12
Ian H de Boer, Xiaoyu Gao, Ionut Bebu, Andrew N Hoofnagle, John M Lachin, Andrew Paterson, Bruce A Perkins, Amy K Saenger, Michael W Steffes, Bernard Zinman, Mark E Molitch
Objective: To evaluate biomarkers of renal tubulointerstitial damage and function in type 1 diabetes with and without diabetic kidney disease. Research design and methods: Cross-sectional case-control study of Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study participants. Cases (N=43) had incident persistent estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 with urinary albumin excretion >300 mg/24 hour...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29171088/comparison-of-single-averaged-and-pooled-urine-protein-creatinine-ratios-in-proteinuric-dogs-undergoing-medical-treatment
#13
S Shropshire, J Quimby, R Cerda
BACKGROUND: Monitoring urine protein:creatinine ratios (UPC) in dogs with protein-losing nephropathy (PLN) is challenging because of day-to-day variation in UPC results. HYPOTHESIS/OBJECTIVES: Determine whether single, averaged, or pooled samples from PLN dogs receiving medical treatment yield comparable UPCs, regardless of degree of proteinuria. ANIMALS: Twenty-five client-owned PLN dogs receiving medical treatment. METHODS: UPC ratios were prospectively measured in each dog utilizing 3 methods: single in-hospital sample (day 3), average sample (days 1-3), and pooled sample (equal pooling of urine from days 1-3)...
November 24, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29167190/an-outcomes-based-definition-of-proteinuria-remission-in-focal-segmental-glomerulosclerosis
#14
Jonathan P Troost, Howard Trachtman, Patrick H Nachman, Matthias Kretzler, Cathie Spino, Radko Komers, Sarah Tuller, Kalyani Perumal, Susan F Massengill, Elaine S Kamil, Gia Oh, David T Selewski, Patrick Gipson, Debbie S Gipson
BACKGROUND AND OBJECTIVES: Proteinuria is used as an indicator of FSGS disease activity, but its use as a clinical trial end point is not universally accepted. The goal of this study was to refine proteinuria definitions associated with long-term kidney survival. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Data on 466 patients with primary FSGS with proteinuria (urine protein-to-creatinine ratio >1 g/g) were analyzed from five independent cohorts. Proteinuria by months 1, 4, and 8 after study baseline was categorized by conventional definitions of complete (<0...
November 22, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29155873/short-term-anti-proteinuric-effect-of-tacrolimus-is-not-related-to-preservation-of-the-glomerular-filtration-rate-in-iga-nephropathy-a-5-year-follow-up-study
#15
Mi-Yeon Yu, Yong-Chul Kim, Ho Suk Koo, Ho Jun Chin
BACKGROUND: The immunosuppressive drug tacrolimus has the short-term effect of reducing proteinuria in patients with immunoglobulin A nephropathy (IgAN). Our study investigated the effects on proteinuria and kidney function after discontinuation of tacrolimus. METHODS: Patients with biopsy-proven IgAN were included in the study and randomly divided into two treatment groups. There was a corresponding control group for each treatment group. The first group included patients treated with tacrolimus (Tac vs non-Tac group) and the second group included patients with a renin angiotensin system blocker (RASi vs non-RASi group)...
2017: PloS One
https://www.readbyqxmd.com/read/29155846/soluble-cd40-ligand-directly-alters-glomerular-permeability-and-may-act-as-a-circulating-permeability-factor-in-fsgs
#16
Sophie Doublier, Cristina Zennaro, Luca Musante, Tiziana Spatola, Giovanni Candiano, Maurizio Bruschi, Luca Besso, Massimo Cedrino, Michele Carraro, Gian Marco Ghiggeri, Giovanni Camussi, Enrico Lupia
CD40/CD40 ligand (CD40L) dyad, a co-stimulatory bi-molecular complex involved in the adaptive immune response, has also potent pro-inflammatory actions in haematopoietic and non-haematopoietic cells. We describe here a novel role for soluble CD40L (sCD40L) as modifier of glomerular permselectivity directly acting on glomerular epithelial cells (GECs). We found that stimulation of CD40, constitutively expressed on GEC cell membrane, by the sCD40L rapidly induced redistribution and loss of nephrin in GECs, and increased albumin permeability in isolated rat glomeruli...
2017: PloS One
https://www.readbyqxmd.com/read/29155503/relatives-in-silent-kidney-disease-screening-risks-study-a-chinese-cohort-study
#17
Philip Kam-Tao Li, Jack Kit-Chung Ng, Yuk Lun Cheng, Tze Hoi Kwan, Chi Bon Leung, Miu Fong Lau, Koon Shing Choi, Samuel Ka-Shun Fung, Yiu Wing Ho, Siu Ka Mak, Sydney Chi-Wai Tang, Kin Shing Wong, David Yong, Sing Leung Lui
AIM: Family members of patients with end-stage renal disease (ESRD) have higher risk for chronic kidney disease (CKD). Limited study has examined the risk of developing CKD in relatives of patients in earlier stages of CKD. METHODS: From January 2008 to June 2009, the Hong Kong Society of Nephrology studied first-degree relatives of stage 1-5 CKD patients from 11 local hospitals. A total of 844 relatives of 466 index CKD patients (stages 1-2: 29.6%; stage 3: 16...
December 2017: Nephrology
https://www.readbyqxmd.com/read/29153006/effect-of-bariatric-surgery-on-diabetic-nephropathy-in-obese-type-2-diabetes-patients-in-a-retrospective-2-year-study-a-local-pilot
#18
Anthony Tl Chao, Sum Chee Fang, Benjamin Cc Lam, Anton Ks Cheng, Serena Km Low, Lim Su Chi
PURPOSE: To determine the effects of bariatric surgery on albuminuria in obese patients with type 2 diabetes mellitus. METHODS: Retrospective analyses of clinical records of obese patients with type 2 diabetes mellitus who had either micro- or macroalbuminuria and had undergone various bariatric surgery were retrieved from a local hospital database. Their clinical data from follow-up appointments including albuminuria were analysed. RESULTS: Of the 46 subjects with type 2 diabetes mellitus, 15 subjects had diabetic nephropathy and had pre- and post-bariatric surgery urine albumin-to-creatinine ratio or urine protein-to-creatinine ratio data available for analysis; 13 out of the 15 subjects (86...
November 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29150790/clinical-study-on-yishen-qufeng-shengshi-recipe-for-glomerular-proteinuria-patients-a-randomized-controlled-trial
#19
Qin Dai, Pei-Qing Zhang, Xiao-Qin Wang, Li-Fang Nie, Xiao-Jun Fu, Wen Peng, Yi Wang, Jun Li, Yue-Ping Bi, Xiu-Hua Mi, Min Yuan, Li-Qun He
OBJECTIVE: To explore the therapeutic effect of Yishen Qufeng Shengshi Recipe (, YQSR) in patients with glomerular proteinuria. METHODS: A total of 145 patients with glomerular proteinuria were selected and randomly assigned to the treatment group (108 cases) and the control group (37 cases) according to a random number table in a ratio of 3:1. All patients received conventional and symptomatic treatment. In addition, patients in the treatment and control groups were given YQSR (200 mL, twice per day, orally) and losartan (50 mg/d orally), respectively for 6 months...
November 17, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29142952/serum-ngal-and-cystatin-c-comparison-with-urinary-albumin-to-creatinine-ratio-and-inflammatory-biomarkers-as-early-predictors-of-renal-dysfunction-in-patients-with-type-2-diabetes
#20
Marcelo R Bacci, Ethel Z Chehter, Ligia A Azzalis, Beatriz Costa de Aguiar Alves, Fernando L A Fonseca
Introduction: Diabetic nephropathy is associated with specific histological changes. Early detection of poor glomerular and tubular function can be achieved with biomarkers of diabetes. The aim of this study was to evaluate the accuracy of kidney dysfunction biomarkers in type 2 diabetes (T2D). Methods: Patients with T2D were grouped according to their glycated hemoglobin level. Patients' urine and blood samples were taken to measure cystatin C (CysC), neutrophil gelatinase-associated lipocalin, beta-trace protein levels, and the first morning void albumin-to-creatinine ratio...
March 2017: KI Reports
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