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proteín creatinine ratio in urine in diabetic nephropathy

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https://www.readbyqxmd.com/read/28912839/addition-of-nonalbumin-proteinuria-to-albuminuria-improves-prediction-of-type-2-diabetic-nephropathy-progression
#1
Jong Ho Kim, Seo Young Oh, Eun Heui Kim, Min Jin Lee, Yun Kyung Jeon, Bo Hyun Kim, Jin Mi Kim, Yong Ki Kim, Sang Soo Kim, In Joo Kim
BACKGROUND: Albuminuria is generally accepted as a sensitive marker of diabetic nephropathy but has limitations in predicting its progression. The aim of this study was to evaluate the use of nonalbumin proteinuria in addition to albuminuria for predicting the progression of type 2 diabetic nephropathy. METHODS: In this retrospective observational study, the urine albumin-to-creatinine ratio (ACR) and the nonalbumin protein-to-creatinine ratio (NAPCR) were measured in 325 patients with type 2 diabetes and estimated glomerular filtration rates (eGFR) ≥30 mL/min/1...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28903970/urinary-fibrinogen-as-a-predictor-of-progression-of-ckd
#2
Hongtian Wang, Chunxia Zheng, Yinghui Lu, Qi Jiang, Ru Yin, Ping Zhu, Minlin Zhou, Zhihong Liu
BACKGROUND AND OBJECTIVES: Fibrinogen has been reported to be involved in kidney tubulointerstitial fibrosis and podocyte injury in mouse models. However, the relationship between urinary fibrinogen and kidney outcomes has not been clarified in patients with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We evaluated 402 patients with CKD and kidney biopsies, including 101 with diabetic nephropathy, 94 with idiopathic membranous nephropathy, 55 with idiopathic FSGS, and 152 with IgA nephropathy...
September 13, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28885376/clinicopathological-features-of-diabetic-and-nondiabetic-renal-diseases-in-type-2-diabetic-patients-with-nephrotic-range-proteinuria
#3
Yu Ho Lee, Ki-Pyo Kim, Yang Gyun Kim, Ju-Young Moon, Su Woong Jung, Eunji Park, Jin Sug Kim, Kyung-Hwan Jeong, Tae Won Lee, Chun-Gyoo Ihm, Young-Il Jo, Hoon-Young Choi, Hyeong-Cheon Park, So-Young Lee, Dong-Ho Yang, Joo-Hark Yi, Sang-Woong Han, Sang-Ho Lee
Heavy proteinuria with or without features of nephrotic syndrome is associated with many primary and systemic diseases. For diabetic patients, distinguishing nondiabetic renal disease (NDRD) from diabetic nephropathy (DN) is important in choosing treatment modalities and determining renal prognosis. However, clinical relevance of heavy proteinuria is inconsistent with clinical DN assessments. This study investigated the clinicopathological features and renal outcomes of DN and NDRD in type 2 diabetic patients with nephrotic-range proteinuria...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28804725/meprin-metalloprotease-deficiency-associated-with-higher-mortality-rates-and-more-severe-diabetic-kidney-injury-in-mice-with-stz-induced-type-1-diabetes
#4
John E Bylander, Faihaa Ahmed, Sabena M Conley, Jean-Marie Mwiza, Elimelda Moige Ongeri
Meprins are membrane-bound and secreted metalloproteinases consisting of α and/or β subunits that are highly expressed in kidney epithelial cells and are differentially expressed in podocytes and leukocytes (macrophages and monocytes). Several studies have implicated meprins in the progression of diabetic nephropathy (DN) and fibrosis-associated kidney disease. However, the mechanisms by which meprins modulate DN are not understood. To delineate the role of meprins in DN, we subjected meprin αβ knockout (αβKO) mice and their wild-type (WT) counterparts to streptozotocin-induced type 1 diabetes...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28676059/potent-long-acting-rhfgf21-analog-for-treatment-of-diabetic-nephropathy-in-db-db-and-dio-mice
#5
Longwei Zhao, Huiyan Wang, Junjun Xie, Zilu Chen, Xiaokun Li, Jianlou Niu
BACKGROUND: Fibroblast growth factor 21 (FGF21) is an endocrine-acting hormone that has the potential to treat diabetic nephropathy. However, development of FGF21 into a therapeutic has been hindered due to its low intrinsic bio-stability. In our previous study, we have developed a recombinant human FGF21 (rhFGF21) variant by site-directed mutagenesis and solid-phase PEGylation, which retained its biological function. The aim of this study is to elucidate whether the therapeutic effect of PEGylated rhFGF21 (PEG-rhFGF21) on diabetic nephropathy in DIO (diet induced obesity) mice is more significant than rhFGF21 in vivo...
July 4, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28601908/urinary-liver-type-fatty-acid-binding-protein-is-an-independent-predictor-of-stroke-and-mortality-in-individuals-with-type-1-diabetes
#6
Nicolae M Panduru, Carol Forsblom, Markku Saraheimo, Lena M Thorn, Daniel Gordin, Nina Elonen, Valma Harjusalo, Angelika Bierhaus, Per M Humpert, Per-Henrik Groop
AIMS/HYPOTHESIS: In type 1 diabetes, cardiovascular disease (CVD) and diabetic nephropathy progress in parallel, thereby potentiating the risk of premature death during their development. Since urinary liver-type fatty acid binding protein (L-FABP) predicts the progression of diabetic nephropathy, the aim of this study was to investigate whether urinary L-FABP also predicts cardiovascular outcomes and mortality. METHODS: We tested our hypothesis in a Finnish cohort of 2329 individuals with type 1 diabetes and a median follow-up of 14...
June 10, 2017: Diabetologia
https://www.readbyqxmd.com/read/28507626/follow-up-of-value-of-the-intrarenal-resistivity-indices-and-different-renal-biomarkers-for-early-identification-of-diabetic-nephropathy-in-type-1-diabetic-patients
#7
Soha Abd El Dayem, Abo El Magd El Bohy, Mona Hamed, Solaf Ahmed
AIM: To evaluate intrarenal resistivity index (RI) and different biomarkers of diabetic nephropathy (DN) with clinical signs of DN and its progression over time as early detection of DN. PATIENTS AND METHODS: This longitudinal study included 48 type 1 diabetic patients who were studied at baseline and after three years. A blood sample was taken for assessment of glycosylated haemoglobin (HbA1), lipid profile and a urine sample was taken for assessment of albumin/creatinine ratio, Neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid binding protein (L-FABP) and kidney injury molecule-1 (Kim-1) at baseline and after three years...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28294194/phosphodiesterase-5-inhibition-preserves-renal-hemodynamics-and-function-in-mice-with-diabetic-kidney-disease-by-modulating-mir-22-and-bmp7
#8
Riccardo Pofi, Daniela Fiore, Rita De Gaetano, Giuseppe Panio, Daniele Gianfrilli, Carlotta Pozza, Federica Barbagallo, Yang Kevin Xiang, Konstantinos Giannakakis, Susanna Morano, Andrea Lenzi, Fabio Naro, Andrea M Isidori, Mary Anna Venneri
Diabetic Nephropathy (DN) is the leading cause of end-stage renal disease. Preclinical and experimental studies show that PDE5 inhibitors (PDE5is) exert protective effects in DN improving perivascular inflammation. Using a mouse model of diabetic kidney injury we investigated the protective proprieties of PDE5is on renal hemodynamics and the molecular mechanisms involved. PDE5i treatment prevented the development of DN-related hypertension (P < 0.001), the increase of urine albumin creatinine ratio (P < 0...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28104821/the-urine-preservative-acetic-acid-degrades-urine-protein-implications-for-urine-biorepositories-and-the-aask-cohort-study
#9
Salem Almaani, Lee A Hebert, Brad H Rovin, Daniel J Birmingham
Patients enrolled in the African American Study of Kidney Disease and Hypertension (AASK) Cohort Study who exhibited overt proteinuria have been reported to show high nonalbumin proteinuria (NAP), which is characteristic of a tubulopathy. To determine whether African American Study of Kidney Disease and Hypertension nephropathy (AASK-N) is a tubulopathy, we obtained urine samples of 37 patients with AASK-N, with 24-hour protein-to-creatinine ratios (milligrams per milligram) ranging from 0.2 to 1.0, from the National Institute of Diabetes and Digestive Kidney Diseases repository and tested for seven markers of tubular proteinuria...
May 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27992535/cleaved-form-of-osteopontin-in-urine-as-a-clinical-marker-of-lupus-nephritis
#10
Koji Kitagori, Hajime Yoshifuji, Takuma Oku, Chiyomi Sasaki, Hitomi Miyata, Keita P Mori, Toshiki Nakajima, Koichiro Ohmura, Daisuke Kawabata, Naoichiro Yukawa, Yoshitaka Imura, Kosaku Murakami, Ran Nakashima, Takashi Usui, Takao Fujii, Kaoru Sakai, Motoko Yanagita, Yoshitaka Hirayama, Tsuneyo Mimori
We assessed the utility of two forms of osteopontin (OPN), OPN full and its cleaved form (OPN N-half), in plasma and urine as markers of disease activity in lupus nephritis (LN). Samples were collected from patients with systemic lupus erythematosus (SLE) (LN: N = 29, non-LN: N = 27), IgA nephropathy (IgAN) (N = 14), minimal change nephrotic syndrome (MCNS) (N = 5), diabetic nephropathy (DN) (N = 14) and healthy volunteers (HC) (N = 17). While there was no significant difference in urine OPN full concentration between groups, urine OPN N-half concentration was significantly higher in patients with LN than HC (p < 0...
2016: PloS One
https://www.readbyqxmd.com/read/27913013/nonalbumin-proteinuria-is-a-simple-and-practical-predictor-of-the-progression-of-early-stage-type-2-diabetic-nephropathy
#11
Jong Ho Kim, Sang Soo Kim, In Joo Kim, Min Jin Lee, Yun Kyung Jeon, Bo Hyun Kim, Sang Heon Song, Yong Ki Kim
AIMS: Multiple biomarkers have emerged as a reliable predictor of the progression of diabetic nephropathy. The aim of this study was to pursue a more simple and practical predictor that can be applied in clinical practice. METHODS: The urine albumin-to-creatinine ratio (ACR), the nonalbumin protein-to-creatinine ratio (NAPCR), and the levels of six biomarkers were measured in 73 patients with type 2 diabetes and estimated glomerular filtration rates (eGFRs)≥60mL/min/1...
November 12, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27759340/the-role-of-smoking-as-a-modifiable-risk-factor-in-diabetic-nephropathy
#12
M Jija Jose, Vipin Varkey, R Chandni, P A Zubaida, Jean Maliekkal
OBJECTIVE: To study the relation of smoking and abnormal renal function in type 2 diabetes mellitus by estimating urine protein- creatinine ratio, blood urea, serum creatinine, glomerular filtration rate and serum lipid profile in selected subjects. METHODS: Diabetic patients who attended the Diabetic Clinic, Medical College, Kozhikode were enrolled in the study. The study duration was 6 months, from July 2008 to December 2008. It was conducted in four groups of 40 subjects: diabetic smokers, diabetic non-smokers, non-diabetic smokers and non-diabetic non-smokers...
July 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27725943/reversal-of-early-diabetic-nephropathy-by-islet-transplantation-under-the-kidney-capsule-in-a-rat-model
#13
Yunqiang He, Ziqiang Xu, Mingshi Zhou, Minmin Wu, Xuehai Chen, Silu Wang, Kaiyan Qiu, Yong Cai, Hongxing Fu, Bicheng Chen, Mengtao Zhou
Objective. Diabetic nephropathy (DN) is a common microvascular complication of diabetes mellitus, and insulin therapy has many side effects in the treatment of DN. Islet transplantation has emerged as a promising therapy for diabetic patients. This study was established to investigate its advantageous effects in a rat model of early DN. Methods. Streptozotocin was administered to the rats to induce diabetes. Twelve weeks later, the diabetic rats were divided into 3 groups: the islet-transplanted group (IT group), the insulin-treated group (IN group), and the untreated group (DN group)...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27660406/effects-and-safety-of-linagliptin-as-an-add-on-therapy-in-advanced-stage-diabetic-nephropathy-patients-taking-renin-angiotensin-aldosterone-system-blockers
#14
Yuichiro Ueda, Hiroki Ishii, Taisuke Kitano, Mitsutoshi Shindo, Haruhisa Miyazawa, Kiyonori Ito, Keiji Hirai, Yoshio Kaku, Honami Mori, Taro Hoshino, Susumu Ookawara, Masafumi Kakei, Kaoru Tabei, Yoshiyuki Morishita
BACKGROUND: We investigated the effects and safety of linagliptin as an add-on therapy in patients with advanced-stage diabetic nephropathy (DMN) taking renin-angiotensin-aldosterone system (RAAS) blockers. METHOD: Twenty advanced-stage DMN patients (estimated glomerular filtration rate (eGFR): 24.5 ± 13.4 mL/min/1.73 m(2)) taking RAAS blockers were administered 5 mg/day linagliptin for 52 weeks. Changes in glucose and lipid metabolism and renal function were evaluated...
2016: Drug Target Insights
https://www.readbyqxmd.com/read/27647855/anti-tgf-%C3%AE-1-antibody-therapy-in-patients-with-diabetic-nephropathy
#15
RANDOMIZED CONTROLLED TRIAL
James Voelker, Paul H Berg, Matthew Sheetz, Kevin Duffin, Tong Shen, Brian Moser, Tom Greene, Samuel S Blumenthal, Ivan Rychlik, Yoram Yagil, Philippe Zaoui, Julia B Lewis
TGF-β has been implicated as a major pathogenic factor in diabetic nephropathy. This randomized, double-blind, phase 2 study assessed whether modulating TGF-β1 activity with a TGF-β1-specific, humanized, neutralizing monoclonal antibody (TGF-β1 mAb) is safe and more effective than placebo in slowing renal function loss in patients with diabetic nephropathy on chronic stable renin-angiotensin system inhibitor treatment. We randomized 416 patients aged ≥25 years with type 1 or type 2 diabetes, a serum creatinine (SCr) level of 1...
March 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27578124/the-effects-of-high-dose-vitamin-e-supplementation-on-biomarkers-of-kidney%C3%A2-injury-inflammation-and-oxidative%C3%A2-stress-in-patients-with-diabetic-nephropathy-a-randomized-double-blind-placebo-controlled-trial
#16
Parisa Golriz Khatami, Alireza Soleimani, Nasrin Sharifi, Esmat Aghadavod, Zatollah Asemi
BACKGROUND: Limited data are available that evaluated the effects of high-dose vitamin E supplementation on biomarkers of kidney injury, inflammation, and oxidative stress in patients with diabetic nephropathy (DN). OBJECTIVE: This study was conducted to evaluate the effects of high-dose vitamin E supplementation on biomarkers of kidney injury, inflammation, and oxidative stress in patients with DN. METHODS: This randomized double-blind placebo-controlled clinical trial was carried out among 60 patients with DN...
July 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27546995/association-of-serum-adropin-concentrations-with-diabetic-nephropathy
#17
Wenchao Hu, Li Chen
Objective. Adropin is a newly identified regulatory protein encoded by the Enho gene and is critically involved in energy homeostasis and insulin sensitivity. This study aims to determine the correlation of serum adropin concentrations with diabetic nephropathy (DN). Methods. This study consisted of 245 patients with type 2 diabetes mellitus (T2DM) and 81 healthy subjects. Then T2DM patients were divided into normoalbuminuria, microalbuminuria, and macroalbuminuria subgroups based on urine albumin to creatinine ratio (ACR)...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27496229/semi-individualised-chinese-medicine-treatment-as-an-adjuvant-management-for-diabetic-nephropathy-a-pilot-add-on-randomised-controlled-multicentre-open-label-pragmatic-clinical-trial
#18
Kam Wa Chan, Tai Pang Ip, Alfred Siu Kei Kwong, Sing Leung Lui, Gary Chi Wang Chan, Benjamin John Cowling, Wai Han Yiu, Dickson Wai Leong Wong, Yang Liu, Yibin Feng, Kathryn Choon Beng Tan, Loretta Yuk Yee Chan, Joseph Chi Kam Leung, Kar Neng Lai, Sydney Chi Wai Tang
INTRODUCTION: Diabetes mellitus and diabetic nephropathy (DN) are prevalent and costly to manage. DN is the leading cause of end-stage kidney disease. Conventional therapy blocking the renin-angiotensin system has only achieved limited effect in preserving renal function. Recent observational data show that the use of Chinese medicine (CM), a major form of traditional medicine used extensively in Asia, could reduce the risk of end-stage kidney disease. However, existing clinical practice guidelines are weakly evidence-based and the effect of CM remains unclear...
August 5, 2016: BMJ Open
https://www.readbyqxmd.com/read/27303100/randomized-control-trial-for-the-assessment-of-the-anti-albuminuric-effects-of-topiroxostat-in-hyperuricemic-patients-with-diabetic-nephropathy-the-etude-study
#19
Sawako Kato, Masahiko Ando, Toshihiro Mizukoshi, Takanobu Nagata, Takayuki Katsuno, Tomoki Kosugi, Naotake Tsuboi, Shoichi Maruyama
Proteinuria is an established risk factor for diabetic nephropathy. Recent studies indicate that some xanthine oxidase inhibitors have a renoprotective effect. The aim of this study was to assess whether topiroxostat reduces albuminuria in hyperuricemic patients with diabetic nephropathy and overt proteinuria. The ETUDE study is an ongoing 24-week, multicenter, open-label, randomized (1:1), parallel group study involving hyperuricemic patients with diabetic nephropathy (estimated glomerular filtration rate [eGFR] ≥ 20 mL/min/1...
May 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/27158221/evaluation-of-ischemia-modified-albumin-malondialdehyde-and-advanced-oxidative-protein-products-as-markers-of-vascular-injury-in-diabetic-nephropathy
#20
Afzal Ahmad, Poornima Manjrekar, Charu Yadav, Ashish Agarwal, Rukmini Mysore Srikantiah, Anupama Hegde
AIM: This study aimed at evaluation of ischemia-modified albumin (IMA), malondialdehyde (MDA), and advanced oxidative protein products (AOPP) as markers of vascular injury in diabetic nephropathy (DN) with derivation of cutoff values for the same. MATERIALS AND METHODS: Study population comprised 60 diabetes patients and 30 controls, with diabetes patients further categorized into three groups based on urine albumin/creatinine ratio (UACR) of <30 mg/g (diabetes without microalbuminuria), 30-300 mg/g (early DN), and >300 mg/g of creatinine (overt DN)...
2016: Biomarker Insights
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