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Keywords proteín creatinine ratio in u...

proteín creatinine ratio in urine in diabetic nephropathy

https://read.qxmd.com/read/33116827/modulation-of-calcium-homeostasis-may-be-associated-with-susceptibility-to-renal-cell-carcinoma-in-diabetic-nephropathy-rats
#1
JOURNAL ARTICLE
Yueming Luo, Zhaoyu Lu, Ana Maria Waaga-Gasser, Haifeng Yang, Jialing Liu, Juan Wu, Jiayan Lu, Xusheng Liu, Lei Zhang
Introduction: Clinical studies have indicated a relationship between diabetic nephropathy (DN) and the incidence and prevalence of renal cell carcinoma (RCC). However, the mechanism linking diabetic nephropathy and renal cell carcinoma has not yet to be identified. Methods: In this study, a total of 42 male Sprague Dawley (SD) rats were randomly assigned to a DN group (n=35) and a control group (n=7). All animals in the DN group were unilaterally nephrectomized and treated with streptozotocin with the development of blood glucose levels >16...
2020: Cancer Management and Research
https://read.qxmd.com/read/33047279/the-effect-of-tropisetron-on-oxidative-stress-sirt1-foxo3a-and-claudin-1-in-the-renal-tissue-of-stz-induced-diabetic-rats
#2
JOURNAL ARTICLE
Mahrokh Samadi, Shiva Gholizadeh-Ghaleh Aziz, Roya Naderi
Tropisetron is a 5-HT3 receptor antagonist that exerts protective effect against DN. The aim of this study was to investigate the possible molecular mechanisms associated with the renoprotective effects of tropisetron in STZ-induced diabetic rats. Animals were subdivided into 5 equal groups; control, tropisetron, diabetes, tropisetron + diabetes, and glibenclamide + diabetes (n = 7). For induction of type 1 diabetes, a single injection of STZ (55 mg/kg, i.p.) was administered to the animals. Diabetic rats were treated with tropisetron (3 mg/kg) and glibenclamide (1 mg/kg) for 2 weeks...
January 2021: Cell Stress & Chaperones
https://read.qxmd.com/read/33033456/evaluation-of-urinary-l-fabp-as-an-early-marker-for-diabetic-nephropathy-in-type-2-diabetic-patients
#3
JOURNAL ARTICLE
Thuy Ngan Duong Thi, Binh Nguyen Gia, Huong Lan Le Thi, Thu Nguyen Cuc Thi, Huong Phung Thanh
BACKGROUND: Albuminuria is the standard biomarker for the diagnosis of diabetic nephropathy (DN). However, some patients with persistent microalbuminuria still progress to chronic kidney disease, raising the question of finding a better biomarker. This study aimed to evaluate the correlation of urinary liver-type fatty acid-binding protein (L-FABP) levels with renal function and to compare the role of urinary albumin-to-creatinine ratio (ACR) with urinary L-FABP in early detection of DN in type 2 diabetic patients...
January 23, 2020: Journal of Medical Biochemistry
https://read.qxmd.com/read/33000199/resveratrol-decreases-high-glucose%C3%A2-induced-apoptosis-in-renal-tubular-cells-via-suppressing-endoplasmic-reticulum-stress
#4
JOURNAL ARTICLE
Jing Zhang, Xiong-Jun Dong, Meng-Ru Ding, Chun-Yu You, Xin Lin, Ying Wang, Miao-Jie-Yang Wu, Guo-Fei Xu, Guo-Dong Wang
Diabetic nephropathy (DN) is the second most common complication of diabetes mellitus after cardiovascular complications. Endoplasmic reticulum (ER) stress is known to be associated with DN. Resveratrol (RSV) exhibits anti‑oxidative, anti‑inflammatory and cytoprotective effects. Therefore, the aims of the present study were to investigate the role of RSV in the inhibition of high concentration glucose (HG)‑induced apoptosis in renal tubular cells, as well as to examine the protective effects of RSV against diabetes‑mediated renal damage via inhibition of ER stress in DN...
November 2020: Molecular Medicine Reports
https://read.qxmd.com/read/32900697/anti-inflammatory-antioxidant-and-renoprotective-effects-of-socs1-mimetic-peptide-in-the-btbr-ob-ob-mouse-model-of-type-2-diabetes
#5
JOURNAL ARTICLE
Lucas Opazo-Ríos, Yenniffer Sanchez Matus, Raúl R Rodrigues-Díez, Daniel Carpio, Alejandra Droguett, Jesús Egido, Carmen Gomez-Guerrero, Sergio Mezzano
INTRODUCTION: Diabetic nephropathy (DN) is the leading cause of chronic kidney disease worldwide. The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway participates in the development and progression of DN. Among the different mechanisms involved in JAK/STAT negative regulation, the family of suppressor of cytokine signaling (SOCS) proteins has been proposed as a new target for DN. Our aim was to evaluate the effect of SOCS1 mimetic peptide in a mouse model of obesity and type 2 diabetes (T2D) with progressive DN...
September 2020: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/32818092/effect-of-a-single-intravitreal-bevacizumab-injection-on-proteinuria-in-patients-with-diabetes
#6
JOURNAL ARTICLE
Yoo-Ri Chung, Young Ho Kim, Hye-Eun Byeon, Dong Hyun Jo, Jeong Hun Kim, Kihwang Lee
Purpose: Proteinuria is the second most common complication after hypertension after systemic administration of bevacizumab. Therefore we aimed to analyze the effect of intravitreal bevacizumab (IVB) injection on proteinuria in patients with diabetes. Methods: Patients scheduled to receive IVB injection from May 1, 2018, to December 31, 2018, were prospectively enrolled. In total, 53 patients with diabetes (26 with nonproliferative diabetic retinopathy and 27 with proliferative diabetic retinopathy) and 37 patients without diabetes were included...
March 2020: Translational Vision Science & Technology
https://read.qxmd.com/read/32701116/effect-of-febuxostat-on-renal-function-in-patients-from-south-china-with-ckd3-diabetic-nephropathy
#7
JOURNAL ARTICLE
Huang Wen, Zhu Yongling, Zheng Shuying, Wang Jiali, Zhao Yanling
OBJECTIVE: To investigate the efficacy and safety of febuxostat on renal function in CKD stage 3 diabetic nephropathy patients. METHODS: Patients in our hospital with chronic kidney disease (CKD) stage 3 diabetic nephropathy (DN) complicated by high serum uric acid (360 µmol/L) were recruited. Patients were then divided into treatment group and control group according to the random number table method. All the patients received low purine diet, renin-angiotensin-aldosterone system (RAAS) inhibitors, and adequate routine hypoglycemic treatment...
October 2020: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://read.qxmd.com/read/32549781/urinary-nephrin-is-earlier-more-sensitive-and-specific-marker-of-diabetic-nephropathy-than-microalbuminuria
#8
JOURNAL ARTICLE
Irena Kostovska, Katerina Tosheska-Trajkovska, Sonja Topuzovska, Svetlana Cekovska, Goce Spasovski, Ognen Kostovski, Danica Labudovic
BACKGROUND: Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Progressive damage and decline in the number of podocytes often occur in the early stages of DN. Thus, nephrin as a podocyte-specific protein may be regarded as a potential biomarker of early detection of DN. The aim of this study is to determine whether urinary nephrin is an earlier marker in DN than microalbuminuria and to test the significance of urinary nephrin as a marker for early detection of DN...
January 10, 2020: Journal of Medical Biochemistry
https://read.qxmd.com/read/32500512/baicalin-suppresses-renal-fibrosis-through-microrna-124-tlr4-nf-%C3%AE%C2%BAb-axis-in-streptozotocin-induced-diabetic-nephropathy-mice-and-high-glucose-treated-human-proximal-tubule-epithelial-cells
#9
JOURNAL ARTICLE
Shefeng Zhang, Li Xu, Ruifeng Liang, Chenhua Yang, Peiren Wang
Renal fibrosis is a major pathological event in the development of diabetic nephropathy (DN). Baicalin is a flavonoid glycoside that possesses multiple pharmacological properties including anti-fibrotic activity. In the present study, the effects of baicalin on renal fibrosis along with related molecular basis were investigated in streptozotocin (STZ)-induced DN mouse model and high glucose (HG)-treated HK-2 human proximal tubule epithelial cell model. Renal injury was evaluated through blood urea nitrogen (BUN) and serum creatinine (Scr) levels and urine albumin creatine ratio (ACR)...
August 2020: Journal of Physiology and Biochemistry
https://read.qxmd.com/read/32456088/punicalagin-protects-diabetic-nephropathy-by-inhibiting-pyroptosis-based-on-txnip-nlrp3-pathway
#10
JOURNAL ARTICLE
Xin An, Yahui Zhang, Yuan Cao, Jihua Chen, Hong Qin, Lina Yang
Diabetic nephropathy is a diabetic complication caused by chronic inflammation. As the primary polyphenol in pomegranate, punicalagin is believed to have significant anti-inflammatory properties. In this study, we established a mice model for diabetes induced by high-fat diet (HFD)/ streptozotocin (STZ) to verify the protective effect of punicalagin in vivo. The results show that the blood urea nitrogen (BUN), serum creatinine (CREA), and the urine albumin to creatinine ratio (UACR) were significantly decreased in diabetic mice after punicalagin intervention, and the symptoms of glomerular interstitial hyperplasia and glomerular hypertrophy were alleviated...
May 22, 2020: Nutrients
https://read.qxmd.com/read/32441195/mir-136-improves-renal-fibrosis-in-diabetic-rats-by-targeting-down-regulation-of-tyrosine-kinase-syk-and-inhibition-of-tgf-%C3%AE-1-smad3-signaling-pathway
#11
JOURNAL ARTICLE
Lei Liu, Xinlu Pang, Wenjun Shang, Guiwen Feng, Zhigang Wang, Junxiang Wang
Objective: To investigate the way that miR-136 regulated spleen tyrosine kinase (SYK) and transforming growth factor-β1 (TGF-β1)/Smad3 signaling pathways on renal fibrosis. Methods: 100 male SD (Sprague-Dawley) rats were randomly divided into diabetic nephropathy (DN) group, normal control (NC) group, miR-136 mimics group, and control group. The renal fibrosis model of diabetic rats was established by streptozotocin (STZ) method. NRK-52E cells were transfected into six groups: HG group, HG + miR-136 group, HG + miR-NC group, miR-136 + SYK group, miR-136 + NC group, and control group...
November 2020: Renal Failure
https://read.qxmd.com/read/32432765/mir-185-3p-downregulates-advanced-glycosylation-end-product-receptor-expression-and-improves-renal-function-in-diabetic-nephropathy-mice
#12
JOURNAL ARTICLE
X-X Xue, H-Q Lei, L Zhao, X-Y Wang, Z Wang, L-Y Xie, J-H Jia
OBJECTIVE: To investigate the effects of the downregulation of AGER by miRNA-185-3p on renal function in diabetic nephropathy (DN) mice. MATERIALS AND METHODS: Mice were divided into normal, model, NC, miR-185-3p mimic, si-AGER, and miR-185-3p mimic + si-AGER groups. Eight weeks following the establishment of the model, various indicators were assessed. RESULTS: Compared to control groups, miR-185-3p expression, body weight, superoxide dismutase (SOD) content, catalase (CAT) content, proliferation, S-phase ratios, and proliferating cell nuclear antigen (PCNA) expression were significantly lower in all experimental groups, whilst AGER expression, water intake, food intake, urine volume, urine protein content, serum creatinine (Scr), Blood Urea Nitrogen (BUN), MDA content, G0/G1 status, and rates of apoptosis were significantly higher (all p<0...
May 2020: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/32399849/sleeve-gastrectomy-attenuates-diabetic-nephropathy-by-upregulating-nephrin-expressions-in-diabetic-obese-rats
#13
JOURNAL ARTICLE
Yacheng Xiong, Wei Zhu, Qian Xu, Rexiati Ruze, Zhibo Yan, Jianwen Li, Sanyuan Hu, Mingwei Zhong, Yugang Cheng, Guangyong Zhang
PURPOSE: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, and sleeve gastrectomy (SG) is considered to be an effective strategy to improve pre-existing DN. However, the mechanism remains unknown. MATERIALS AND METHODS: Animal model of DN was induced by high-fat diet (HFD) and streptozotocin (STZ). SG or sham surgery was performed and rats were sacrificed at 4, 8, and 12 weeks after surgery. The basic parameters (blood glucose, body weight, kidney weight), indicators of renal function including serum creatinine (Scr), blood urea nitrogen (BUN), urine microalbumin, urine creatinine (Ucr), microalbumin creatinine ratio (UACR), ultrastructural changes of glomerulus, and the expression of nephrin gene and protein in glomerular podocytes were compared among groups...
August 2020: Obesity Surgery
https://read.qxmd.com/read/32337271/association-between-renal-podocalyxin-expression-and-renal-dysfunction-in-patients-with-diabetic-nephropathy-a-single-center-retrospective-case-control-study
#14
JOURNAL ARTICLE
Rongzhen Wang, Can Yao, Feng Liu
This retrospective study investigated whether podocalyxin expression in renal biopsies and urine of patients with diabetic nephropathy (DN) is associated with renal function. This retrospective study included 32 patients with nephropathy, secondary to type 2 diabetes treated at the First Hospital of Lanzhou University (January 2010 to January 2015). Compared with the control group, the DN group had a significantly lower renal expression of podocalyxin and higher urinary podocalyxin/creatinine ratio. Patients with DN were divided into the high and low expression groups according to podocalyxin expression in renal tissues...
2020: BioMed Research International
https://read.qxmd.com/read/32311421/silencing-peg3-inhibits-renal-fibrosis-in-a-rat-model-of-diabetic-nephropathy-by-suppressing-the-nf-%C3%AE%C2%BAb-pathway
#15
JOURNAL ARTICLE
Tianjun Guan, Fan Fang, Xiaoxuan Su, Kaiqiang Lin, Qing Gao
As paternally expressed gene 3 (PEG3), which can activate NF-κB pathway, plays an important role in the development of renal fibrosis in diabetic nephropathy (DN), the present study aimed to investigate the interaction of PEG3 and the NF-κB pathway on renal fibrosis in a DN model. Following the induction of the rat model of DN, a series of experiments were used to measure serum creatinine (Scr), blood urea nitrogen (BUN), urine protein for 24 h (UP24 h), proliferation of renal fibroblasts, positive expression of PEG3, Collagen I and Collagen II protein, the activity of NF-κB, collagen fiber expression and the FSP1+ cell ratio (fibroblast marker, reflecting renal fibrosis)...
August 1, 2020: Molecular and Cellular Endocrinology
https://read.qxmd.com/read/32203727/changes-in-proteinuria-and-diagnosing-preeclampsia-in-ckd-pregnancy
#16
JOURNAL ARTICLE
Adam Morton, Michael Burke, Elizabeth Jarvis, Sailesh Kumar
The diagnosis of preeclampsia superimposed on underlying kidney disease is complicated by physiological changes in renal function, blood pressure and proteinuria during pregnancy. Previous studies have demonstrated a significant increase in proteinuria during pregnancy in women with diabetic nephropathy in the absence of superimposed preeclampsia. There is a paucity of studies addressing changes in proteinuria during pregnancy in other conditions causing chronic kidney disease. A retrospective audit of changes in urine protein:creatinine ratios in 68 pregnancies to women with preconception proteinuria was performed, to determine whether changes in proteinuria may be useful in diagnosing preeclampsia...
April 2020: Pregnancy Hypertension
https://read.qxmd.com/read/32096274/panel-of-novel-urine-biomarkers-for-incident-microalbuminuria-in-people-with-type-2-diabetes-mellitus
#17
JOURNAL ARTICLE
S Yamashita, T Shinozaki, H Murata, Y Matsuyama, T Babazono
AIM: The need to identify novel biomarkers for early diagnosis and treatment of diabetic nephropathy is widely recognized. However, only a few studies have investigated the association between biomarkers and the onset of albuminuria. In this study, we aimed to investigate a panel of biomarkers suitable for predicting microalbuminuria. METHODS: Some 346 Japanese people with type 2 diabetes exhibiting normoalbuminuria were studied. The endpoint was defined as the onset of microalbuminuria...
February 24, 2020: Diabetic Medicine: a Journal of the British Diabetic Association
https://read.qxmd.com/read/32076626/mangiferin-alleviates-renal-interstitial-fibrosis-in-streptozotocin-induced-diabetic-mice-through-regulating-the-pten-pi3k-akt-signaling-pathway
#18
JOURNAL ARTICLE
Yanyan Song, Wei Liu, Ke Tang, Junting Zang, Dong Li, Hang Gao
Renal interstitial fibrosis is considered to be the typical manifestation of diabetic nephropathy (DN). Mangiferin has shown positive effect on the prevention or treatment of diabetes and its complications. The aim of this study was to explore the inhibitive effect and mechanism of mangiferin on renal interstitial fibrosis in diabetic mice. Streptozotocin- (STZ-) induced diabetic mice were treated with mangiferin (15, 30, and 60 mg/kg/d) for 4 weeks. The morphology of kidneys was observed by Masson's trichrome staining, and the biochemical parameters (fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), blood urea nitrogen (BUN), serum creatinine (SCr), and urine protein) were determined by kits...
2020: Journal of Diabetes Research
https://read.qxmd.com/read/31905169/attenuation-of-diabetic-kidney-injury-in-dpp4-deficient-rats-role-of-glp-1-on-the-suppression-of-age-formation-by-inducing-glyoxalase-1
#19
JOURNAL ARTICLE
Mithun Kumer Sarker, Jong Han Lee, Dae Ho Lee, Kwang-Hoon Chun, Hee-Sook Jun
Dipeptidyl peptidase 4 (DPP4) inactivates incretin hormone glucagon-like peptide-1. DPP4 inhibitors may exert beneficial effects on diabetic nephropathy (DN) independently of glycemic control; however, the mechanisms underlying are not fully understood. Here, we investigated the mechanisms of the beneficial effects of DPP4 inhibition on DN using DPP4-deficient (DPP4-def) rats and rat mesangial cells.Blood glucose and HbA1c significantly increased by streptozotocin (STZ) and no differences were between WT-STZ and DPP4-def-STZ...
January 6, 2020: Aging
https://read.qxmd.com/read/31722957/assessment-of-two-novel-renal-tubular-proteins-in-type-2-diabetic-patients-with-nephropathy
#20
JOURNAL ARTICLE
Muhammad Tarek Abdel Ghafar, Khaled Hamed Shalaby, Hanaa Ibrahim Okda, Rehab E Abo El Gheit, Nema Ali Soliman, Walaa Arafa Keshk
Nephropathy is a common health issue associated with type 2 diabetes mellitus (T2DM). Treatment of diabetic nephropathy (DN) in an early stage can effectively inhibit its progression. Albuminuria is the currently accepted marker for detection of DN.This study aims to evaluate the urinary level of two novel renal tubular proteins (cyclophilin A and periostin) in patients with T2DM and among different nephropathy stages and also to validate the diagnostic accuracy of both cyclophilin A and periostin as potential markers for early prediction of DN relative to albuminuria...
November 12, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
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