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Matthew D Walker, Katherine Dinelle, Rick Kornelsen, Anna Lee, Matthew J Farrer, A Jon Stoessl, Vesna Sossi
BACKGROUND: [18 F]fluorodopa (FDOPA) positron emission tomography (PET) allows assessment of levodopa (LDOPA) metabolism and is widely used to study Parkinson's disease. We examined how [18 F]FDOPA PET-derived kinetic parameters relate the dopamine (DA) and DA metabolite content of extracellular fluid measured by microdialysis to aid in the interpretation of data from both techniques. METHODS: [18 F]FDOPA PET imaging and microdialysis measurements were performed in unilaterally 6-hydroxydopamine-lesioned rats (n = 8) and normal control rats (n = 3)...
2013: EJNMMI Research
Matthew D Walker, Katherine Dinelle, Rick Kornelsen, Siobhan McCormick, Chenoa Mah, James E Holden, Matthew J Farrer, A Jon Stoessl, Vesna Sossi
Longitudinal measurements of dopamine (DA) uptake and turnover in transgenic rodents may be critical when developing disease-modifying therapies for Parkinson's disease (PD). We demonstrate methodology for such measurements using [(18)F]fluoro-3,4-dihydroxyphenyl-L-alanine ([(18)F]FDOPA) positron emission tomography (PET). The method was applied to 6-hydroxydopamine lesioned rats, providing the first PET-derived estimates of DA turnover for this species. Control (n=4) and unilaterally lesioned (n=11) rats were imaged multiple times...
January 2013: Journal of Cerebral Blood Flow and Metabolism
M Morelli, A Pinna
The adenosine A2A receptor antagonist SCH 58261 increases the turning behaviour induced by L-dopa in unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rats. In this study we have evaluated the effect of a chronic intermittent administration of L-dopa or SCH 58261 plus L-dopa on turning behaviour. Chronic intermittent administration of SCH 58261 plus L-dopa produced a stable turning behaviour during the course of the treatment, whereas L-dopa alone produced a progressive increase in turning behaviour. Moreover, repeated administration of SCH 58261 failed to produce tolerance to its ability to potentiate L-dopa-induced turning behaviour...
February 2001: Neurological Sciences
P Soares-da-Silva, M H Fernandes, M Pestana
The accumulation of Ldopa, dopamine (DA) and 3,4-dihydroxyphenylacetic (DOPAC) in kidney slices loaded with Ldopa (10-100 microM) was found to be dependent on the concentration of sodium in the medium (0-160 mM). The constant rate of accumulation did not depend on the concentration of Ldopa used and was about 0.0025, 0.0035 and 0.0065 for Ldopa, DA and DOPAC, respectively. In experiments performed in the presence of 120 and 160 mM sodium, but not with 20 mM sodium in the medium, ouabain (500 and 1000 microM) and amphotericin B (10 and 50 micrograms/ml) significantly reduced the accumulation of both DA and DOPAC (6-21 and 29-56% reduction, respectively)...
January 1993: Journal of Pharmacology and Experimental Therapeutics
Y Sakai, T Deguchi
Studies were carried out to evaluate the antidepressant action of Mianserin as related to noradrenergic and serotonergic systems. The actions of known tricyclic anti-depressants were comparatively investigated together with Mianserin (Organon). Self-stimulation behavior induced by stimulation of the posterior hypothalamus and substantia nigra was unaffected by Mianserin and imipramine, was suppressed with chlorpromazine and markedly enhanced by methamphetamine. The enhancement due to methamphetamine was suppressed by both Mianserin and chlorpromazine, and was potentiated by imipramine...
April 1980: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
L M Ambrani, M H Van Woert
Drugs which reduce central catecholamine activity increased the tremorigenic action physostigmine (0.25 mg/kg) in the rat. The potentiation of physostigmine tremor induced by these neuroleptic drugs was quantitated measuring the ratio of post- to prephysostigmine motor activity; this ratio may be useful index of catecholamine/cholinergic balance. Of the compounds tested, chlorpromazine HC1 (15 mg/kg) and reserpine (10 mg/kg) had the greatest potentiating effect on the tremor-producing action of physostigmine...
October 1972: British Journal of Pharmacology
Z Podolec, J Vetulani, B Bednarczyk, A Szczeklik
Dopaminergic agents, dopa and apomorphine, affected biphasically the blood eosinophil count in the rat: low doses of the drug elevated, while high doses lowered it. The response to a high dose of dopa was retained in rats pretreated with an inhibitor of dopamine-beta-hydroxylase, U 10, 157, but prevented by a centrally acting dopa decarboxylase inhibitor, NSD 1015. This indicates that the eosinopenia observed after large doses of dopa is due to the action of dopamine formed from the precursor. As intracerebroventricular injections of Ldopa also produce eosinopenia, the central site of dopamine action is indicated...
April 2, 1979: Allergy
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