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Safia Fatima, Aamir Ijaz, Tariq Bin Sharif, Dilshad Ahmad Khan, Amer Siddique
OBJECTIVE: To determine the diagnostic accuracy of non-fasting lipid profile in the diagnosis of hyperlipidemia, taking fasting lipid profile as gold standard, in adult population. STUDY DESIGN: Cross-sectional validation study. PLACE AND DURATION OF STUDY: Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi, from July to December 2014. METHODOLOGY: One hundred seventy-five adult patients coming for fasting lipid profile were included; their non-fasting samples were taken on the next day...
December 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Olubukola Sinbad Olorunnisola, Adewale Adetutu, Anthony Jide Afolayan, Abiodun Olusoji Owoade
OBJECTIVE: To investigate the effect of methanolic leaf extract of Talinum triangulare on hematological parameters, enzymatic and non-enzymatic antioxidant status, and serum lipid in Wistar rats fed standard laboratory, or 2% cholesterol-enrich diet. MATERIAL AND METHODS: Wistar rats (180-210g) divided into six groups of six animals (males) each were fed 2% cholesterol-enriched diet and orally treated with 0.9% saline or extract of Talinum triangulare (250, 500, and 1000 mg/kg per body weight) daily for eight weeks...
October 2016: Pharmacognosy Magazine
Vitaris Kodogo, Danai Tavonga Zhou, Olav Oektedalen, Kerina Duri, Babill Stray-Pedersen, Exnevia Gomo
BACKGROUND: Dyslipidemia does not occur in all HIV-infected or antiretroviral therapy-experienced patients suggesting role of host genetic factors but there is paucity of data on association between dyslipidemia and gene polymorphisms in Zimbabwe. OBJECTIVE: To determine association of lipoprotein levels and apolipoprotein B polymorphisms in HIV-infected adults. METHOD: Demographic data were collected from 103 consenting patients; lipoprotein levels were determined and blood samples were successfully genotyped for both apolipoprotein B 2488C>T Xba1 and apolipoprotein B 4154G>A p...
2016: Open AIDS Journal
Dongyan Shao, Yilin Wang, Qingsheng Huang, Junling Shi, Hui Yang, Zhongli Pan, Mingliang Jin, Haobin Zhao, Xiaoguang Xu
Resveratrol (Res) was previously reported to be capable of lowering plasma TC and LDL-C. The mechanism behind Res is not clearly understood, although it is presumed to have an effect on bile acid metabolism in the liver: a significant way in eliminating cholesterol from the body. As one of the major metabolites of Res in the liver, resveratrol glucuronides (Gres) is suspected to also contribute to the overall cholestrol-lowering activity of Res, which needs to be studied. In this research, when HepG2 steatosis hepatic cells were treated with Res and Gres at different concentration levels, Res and Gres showed similar activity in lowering cellular TC content...
October 13, 2016: Journal of Food Science
Fan Yu, Xinhui Tang
Long-circulating liposome is an effective formulation in field of cancer treatment. However, high expenditure of formulation and high dose of cholesterol severely restrict its application. In this paper, we developed a method by grafting polyethylene glycol 2000 on β-sitosterol succinic anhydride ester to obtain relatively cheap polyethylene glycol-β-sitosterol conjugates, which were used to prepare long-circulating liposome without cholesterol. Gambogic acid which is an effective antitumor ingredient with very short half-life, was used as a model drug to prepare long-circulating liposome in this research...
March 2016: Journal of Nanoscience and Nanotechnology
Ghazal Alipour Talesh, Zahra Ebrahimi, Ali Badiee, Mercedeh Mansourian, Hossein Attar, Leila Arabi, Seyed Amir Jalali, Mahmoud Reza Jaafari
In the current study we aimed at developing a vaccine delivery/adjuvant system to enhance anti-tumor immunity against the natural multi-epitope HER2/Neu-derived P5 peptide. Polyriboinosinic: polyribocytidylic acid [Poly (I:C)] is a strong immunoadjuvant able to enhance specific antitumor immunity induced by peptide-based vaccines. Nevertheless, delivering the peptide and adjuvant intracellularly into their target site remains a challenging issue. We hypothesized this barrier could be overcome through the use of a cationic nanoliposome carrier system which can carry and protect the antigen and adjuvant in the extracellular environment and augment the induction of antitumor immunity...
August 2016: Immunology Letters
Swetha Chandru, Prashant Vishwanath, Devananda Devegowda, Suresha Nagaraja Ramasamudra, Akila Prashant, Basavanagowdappa Hathur
INTRODUCTION: The present study was taken up to compare and evaluate the effect of Momordica charantia supplementation with pioglitazone on PKC-β and PPAR-γ activity in kidneys of diabetic rats. The hypoglycaemic and lipid lowering effect of Momordica charantia were screened in laboratory animal model and its potency was compared with a Thiazolidinedione (TZD) group antidiabetic drug like pioglitazone. MATERIALS AND METHODS: Adult healthy albino rats of Wistar strain aged 3-4months, weighing between 170-250gm of either sex were divided into 4 groups; Group 1 (normal controls), Group 2 (diabetic controls), Group 3 (diabetic rats treated with pioglitazone) and Group 4 (diabetic rats treated with bitter melon juice)...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
Zahra Maghsoudi, Roya Kelishadi, Mohammad Javad Hosseinzadeh-Attar
AIMS: The growing prevalence of obesity and its related metabolic disorders in adolescents shows the necessity of urgent focus on the related factors. Adipocytes secretions and their pro- or anti-inflammatory roles play effective roles in adipocytes metabolism. We assessed the relation between adiponectin, chemerin and lipid profile in hit phase of life. METHODS: This case-control study conducted on 78 adolescent girls, divided based on BMI percentile. Serum chemerin, adiponectin, lipid profile and body fat mass were measured...
April 2016: Diabetes & Metabolic Syndrome
Raheleh Assaei, Pooneh Mokarram, Sanaz Dastghaib, Sara Darbandi, Mahsa Darbandi, Fatemeh Zal, Masoumeh Akmali, Gholam Hossein Ranjbar Omrani
BACKGROUND: Traditional medicines with anti-diabetic effects are considered suitable supplements to treat diabetes. Among medicinal herbs, Stevia Rebaudiana Bertoni is famous for its sweet taste and beneficial effect in regulation of glucose. However, little is known about the exact mechanism of stevia in pancreatic tissue. Therefore, this study investigated the possible effects of stevia on pancreas in managing hyperglycemia seen in streptozotocin-induced Sprague-Dawley rats. METHODS: Sprague-Dawley rats were divided into four groups including normoglycemic, diabetic and two more diabetic groups in which, one was treated with aquatic extract of stevia (400 mg/kg) and the other with pioglitazone (10 mg/kg) for the period of 28 days...
April 2016: Avicenna Journal of Medical Biotechnology
Baris Gencer, David Nanchen
PURPOSE OF REVIEW: Familial hypercholesterolemia is a frequent genetic disorder characterized by elevated LDL-cholestrol and premature coronary heart disease. Familial hypercholesterolemia remains largely underdiagnosed in the general population and for many patients the initial clinical manifestation is acute coronary syndromes (ACS). Furthermore, many missed diagnosis of familial hypercholesterolemia can also occur during hospitalization for ACS. In this review, we aim to discuss the identification and prognosis of familial hypercholesterolemia after hospitalization for ACS...
August 2016: Current Opinion in Lipidology
Lukas Schwingshackl, Benjamin Missbach, Georg Hoffmann
PURPOSE: To gain further insight into the strength of evidence and extent of possible biases in the scope of studies investigating the impact of garlic and garlic supplement intake on biomarkers of cardiovascular disease, we performed an umbrella review of all published meta-analyses synthesizing data from both observational studies and randomized controlled trials. METHODS: Electronic database PubMed (between 1966 and June 2015) was searched for systematic reviews and meta-analyses using following search terms: ("garlic" OR "allium sativum" OR "allicin" OR "organosulfur") AND ("cardiovascular" OR "coronary" OR "cholesterol" OR "triglyceride" OR "atherosclerosis" OR "blood pressure" OR "hypertension" OR "blood glucose") AND ("systematic review" OR "meta-analysis"), with no restriction to calendar data and language...
October 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Paula Ramos Pinto, Débora Dias Ferraretto Moura Rocco, Ligia Shimabukuro Okuda, Adriana Machado-Lima, Gabriela Castilho, Karolline Santana da Silva, Diego Juvenal Gomes, Raphael de Souza Pinto, Rodrigo Tallada Iborra, Guilherme da Silva Ferreira, Edna Regina Nakandakare, Ubiratan Fabres Machado, Maria Lucia Cardillo Correa-Giannella, Sergio Catanozi, Marisa Passarelli
BACKGROUND: Regular exercise prevents and regresses atherosclerosis by improving lipid metabolism and antioxidant defenses. Exercise ameliorates the reverse cholesterol transport (RCT), an antiatherogenic system that drives cholesterol from arterial macrophages to the liver for excretion into bile and feces. In this study we analyzed the role of aerobic exercise on the in vivo RCT and expression of genes and proteins involved in lipid flux and inflammation in peritoneal macrophages, aortic arch and liver from wild type mice...
September 16, 2015: Lipids in Health and Disease
F Shaikh, A Basit, R Hakeem, A Fawwad, A Hussain
The aim of this study was to observe the association between maternal undernutrition and metabolic risk indicators in newborns at birth. Fifty-nine expectant mothers between 28 and 40 weeks of gestation were included after obtaining their informed consent. Mothers were divided into undernourished, normally nourished and overnourished groups. A total of 54 deliveries were followed-up, and cord blood samples were collected. Metabolic status at birth was assessed by determining the cord blood concentrations of glucose, insulin and lipids and by measuring insulin resistance through homeostasis model assessment...
August 2015: Journal of Developmental Origins of Health and Disease
Jules Nchoutmboube, Lauren A Ford-Siltz, George A Belov
All (+)RNA viruses replicate on distinct membranous domains; however, how they induce and maintain their unique lipid composition is largely unknown. Two recent studies reveal that enteroviruses harness the PI4P-cholestrol exchange cycle driven by OSBP1 protein and PI4 kinase(s), and that blocking the dynamic lipid flow inhibits virus replication.
April 2015: Trends in Microbiology
Ae Wha Ha, Tian Ying, Woo Kyoung Kim
BACKGROUD/OBEJECTIVES: The mechanism of how black garlic effects lipid metabolism remains unsolved. Therefore, the objectives of this study were to determine the effects of black garlic on lipid profiles and the expression of related genes in rats fed a high fat diet. MATERIALS/METHODS: Thirty-two male Sqrague-Dawley rats aged 4 weeks were randomly divided into four groups (n=8) and fed the following diets for 5 weeks: normal food diet, (NF); a high-fat diet (HF); and a high-fat diet + 0...
February 2015: Nutrition Research and Practice
Olufemi A Fasanmade, Ifedayo A Odeniyi, Christiana O Amira, Njideka U Okubadejo
BACKGROUND: We explored the relationship between anthropometric indices (obesity and abdominal adiposity) and the presence of an atherogenic lipid profile in Nigerians with major cardiovascular risk factors (type 2 diabetes mellitus-T2DM, hypertension-HBP, and concomitant disease). MATERIALS AND METHODS: Using a prospective design, 278 patients with T2DM, HBP, or concomitant disease, attending out-patient diabetes and hypertension clinics at a tertiary institution in Nigeria were evaluated...
November 2013: Nigerian Medical Journal: Journal of the Nigeria Medical Association
Anita B Kale, Sunil B Kale, Shivaji S Chalak, Tankhiwale S R, G Bang, Mohit Agrawal, Meghali Kaple
BACKGROUND: People are aware of the consequences of high serum lipid levels, specifically, total cholesterol. Awareness about harmful effects of very low levels of serum lipids is still lacking. Very low levels of serum lipids lead to psychological consequences. OBJECTIVES: The objective of this study was to show whether there was a significant relationship between serum lipid levels and depression. MATERIAL AND METHODS: Total 70 subjects were included in this study...
January 2014: Journal of Clinical and Diagnostic Research: JCDR
Gopal M G, Ankur Talwar, Sharath Kumar B C, Ramesh M, Nandini A S, Meena H B
BACKGROUND: There has been a lot of recent search on consideration of psoriasis as a systemic disease, with researchers being of the view that dermatological manifestations represent only a part of the spectrum. Although, there have been plenty of studies from the west reporting an association of psoriasis with the metabolic syndrome, there are no large-scale Indian studies evaluating Asian patients. The present study is an endeavour in this regard. AIM: To investigate the prevalence of metabolic syndrome in Indian patients with newly diagnosed psoriasis at the onset of the disease...
December 2013: Journal of Clinical and Diagnostic Research: JCDR
C Chandra Sekhar, Parveen Jindal, V Guru Karna, Manoj Aggarwala, Soma Sekhar
Cholesterol emboli syndrome is due to dislodgment of cholesterol crystals from the atherosclerotic plaques lining the walls of major arteries resulting in an occlusion of small arteries. We describe a case of severe cutaneous and renal cholesterol emboli syndrome following coronary angiography showing our observation that this syndrome is often unrecognized or misdiagnosed and that a better evaluation of risks factors in patients undergoing invasive procedures could prevent this severe complication.
June 2013: Indian Journal of Surgery
Kai Zhang, Xin Li, Hui-xia Yang
OBJECTIVE: To investigate the long-term effects of intrauterine mild hyperglycemia exposure and postnatal high fat diet on the body weight and metabolism of offspring through a pregnant rat model of intrauterine mild hyperglycemia. METHODS: Twenty-one pregnant Wistar rats were randomly divided into intrauterine hyperglycemia group and control group. Twenty percent streptozotocin (STZ, 25 mg/kg)was given to rats of intrauterine hyperglycemia group by a single intraperitoneal injection to induce intrauterine mild hyperglycemia; control group rats received an equal volume of citric acid-sodium citrate buffer...
August 2013: Zhonghua Fu Chan Ke za Zhi
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